Fractions collecting and sampling system and method

Abstract

The invention discloses a fraction collecting and sampling system and method, and relates to the related field of fraction collecting and sampling. The system comprises a solvent bottle; the distribution valve group is respectively connected with a storage pipeline and a conveying pipeline, the distribution valve group can switch the conveying pipeline to be communicated with the switching valve group or the storage pipeline, and a collecting end at the tail end of the conveying pipeline can inject a fraction solution into the solvent bottle or reversely suck the fraction solution in the solvent bottle; the switching valve group is communicated with fraction solution generating equipment, and the tail end of the storage pipeline is communicated with a storage tank; the sampling module comprises a sampling pipeline, an injection pump is arranged on the sampling pipeline, the sampling end of the sampling pipeline can stretch into the solvent bottle for sampling, and a sample is transferred into the sample bottle; the transfer module is connected with the sampling end and the collecting end and can control the sampling end and the collecting end to move to set positions. According to the fraction collecting and sampling system and method, the sample pollution risk can be reduced, and the working efficiency is high.

Description

Technical Field

[0001] The present invention relates to the technical field related to fraction collection and sampling, and in particular to a fraction collection and sampling system and method. Background Art

[0002] In fields such as chemical synthesis, biopharmaceuticals, petrochemicals, and analytical chemistry, it is often necessary to automatically collect outflowing liquid mixtures into different components (fractions). To perform subsequent analysis or further processing on these fractions, it is often necessary to automatically collect samples from the collection container during the collection process (i.e., fraction sampling). Once the samples pass the test, the collected fractions are transferred and stored.

[0003] In conventional industrial fraction collection, sample fraction collection containers are typically large (liter-sized solvent bottles). When samples need to be sampled and tested, they must be manually removed from these large solvent bottles, increasing the risk of sample contamination and reducing work efficiency. Furthermore, existing industrial fraction collection solutions require that the fractions in the solvent bottles be transferred and stored after passing the sample sampling test. Due to the large size and large number of solvent bottles, manual transfer and storage is time-consuming and labor-intensive, further reducing work efficiency.

[0004] Therefore, there is an urgent need to design a technical solution that can reduce the risk of sample contamination and has higher work efficiency. Summary of the Invention

[0005] The purpose of the present invention is to provide a fraction collection and sampling system and method to solve the problems existing in the above-mentioned prior art, reduce the risk of sample contamination, and have high working efficiency.

[0006] To achieve the above object, the present invention provides the following solutions:

[0007] The present invention provides a fraction collection and sampling system, comprising:

[0008] Solvent bottle, used to temporarily store distillate solution;

[0009] The collection module includes a switching valve group and a distribution valve group connected by pipelines. The distribution valve group is respectively connected to a storage pipeline and a delivery pipeline. The distribution valve group can switch the delivery pipeline to communicate with the switching valve group or the storage pipeline. The collection end at the end of the delivery pipeline can inject the distillate solution into the solvent bottle or reversely absorb the distillate solution in the solvent bottle; the switching valve group is connected to the distillate solution generating device, and the end of the storage pipeline is connected to a storage tank;

[0010] The sampling module comprises a sampling pipeline, wherein the sampling pipeline is provided with a syringe pump, and the sampling end of the sampling pipeline is capable of extending into the solvent bottle to take a sample and transfer the sample into the sample bottle;

[0011] The transfer module is connected to the sampling end and the collecting end respectively, and can control the sampling end and the collecting end to move to the set positions respectively.

[0012] Preferably, it also includes a cleaning module, which includes a cleaning tank assembly, the bottom of the cleaning tank assembly is connected to a sewage pipeline, the upper part of the cleaning tank assembly is connected to a bypass valve group, the bypass valve group is connected to an air supply system and a cleaning liquid storage device at one end away from the cleaning tank assembly, and the bypass valve group can respectively introduce cleaning liquid or dry gas into the cleaning tank assembly; the sampling end and the collecting end can be inserted into the cleaning tank assembly; the sampling pipeline is connected to the cleaning liquid storage device away from the sampling end, and the switching valve group is connected to the cleaning liquid storage device through a branch pipeline.

[0013] Preferably, the cleaning tank assembly includes a column cylinder which is hollow inside and open at both ends, the top of the column cylinder is fixedly and sealedly connected to an upper end cover, the bottom of the column cylinder is fixedly and sealedly connected to a lower end cover, the bottom of the lower end cover is connected to the sewage pipe, and the sewage pipe is provided with a switch valve; a diverter is fixedly provided in the upper end cover, and a through hole is provided on the diverter, and the through hole is used to insert the sampling end and / or the collecting end; a channel hole is provided on the side wall of the upper end cover, one end of the channel hole is connected to the bypass valve group, and the other end is connected to the diverter, and a plurality of injection holes are arranged on the side wall of the diverter, and the injection holes can spray cleaning liquid or dry gas into the cleaning tank assembly.

[0014] Preferably, it further comprises connecting rods, a plurality of connecting rods are arranged around the outside of the column, and one end of the connecting rod is fixedly connected to the upper end cover, and the other end of the connecting rod is fixedly connected to the lower end cover.

[0015] Preferably, a sealing gasket is provided at the connection position between the upper end cover and the column barrel, and the sealing gasket is provided at the connection position between the lower end cover and the column barrel; a pressure plate is fixedly provided on the top of the upper end cover, the diverter is provided at the bottom of the pressure plate, and a through hole coaxial with the through hole is provided on the pressure plate; the sampling end and the collecting end can pass through the through hole and the through hole in sequence to enter the column barrel; two sealing rings are provided at the connection position between the outer side of the diverter and the inner side of the upper end cover, and the sealing rings are respectively located above and below the channel hole.

[0016] Preferably, it also includes a base, the transfer module and the cleaning pool assembly are both arranged on the base, a solvent bottle tray and a sample bottle rack are fixedly provided on the base, a plurality of solvent bottles are evenly arranged on the solvent bottle tray, and a plurality of sample bottles are fixedly provided on the sample bottle rack.

[0017] Preferably, the transfer module includes a support seat arranged on the base, a first translation module is provided on the support seat, a second translation module is movably connected to the first translation module, a vertical movement module is provided on the second translation module, and the vertical movement module is connected to the sampling end and the collecting end; the second translation module can move horizontally along the first translation module, the vertical movement module can move horizontally along the second translation module, and the moving direction of the vertical movement module is perpendicular to the moving direction of the second translation module; the sampling end and the collecting end can move up and down respectively along the vertical movement module.

[0018] Preferably, a flow meter is provided between the distribution valve group and the distillate solution generating device, a first delivery pump is provided on the storage pipeline, and a second delivery pump is provided between the cleaning liquid storage device and the bypass valve group.

[0019] The present invention also provides a fraction collection and sampling method, comprising the following steps:

[0020] The distribution valve group is switched to the delivery pipeline and connected to the switching valve group. The distillate solution of the distillate solution generating device flows through the switching valve group to the distribution valve group, enters the delivery pipeline, and is then delivered to the solvent bottle through the collecting end.

[0021] The sampling tip is inserted into the solvent bottle, the syringe pump is started, and the set amount of distillate solution in the solvent bottle is sucked into the sampling tip; then the sampling tip is moved into the sample bottle, and the syringe pump is reversed to pump the set amount of distillate solution in the sampling tip into the sample bottle;

[0022] The solution in the sample bottle is tested. If the test result is qualified, the distribution valve group is switched to connect the delivery pipeline with the storage pipeline, and the distillate solution in the solvent bottle containing the qualified solution is pumped into the storage tank.

[0023] Preferably, a cleaning step is further included, wherein the cleaning step comprises:

[0024] The collecting end and the sampling end are respectively moved into the cleaning tank assembly, the switch valve is closed, and the cleaning liquid is transported to the cleaning tank assembly through the bypass valve group, and the surfaces of the collecting end and the sampling end are sprayed and cleaned until the cleaning liquid fills the cleaning tank assembly;

[0025] Open the switch valve to drain the cleaning fluid in the cleaning tank assembly;

[0026] The switching valve group switches to the branch pipeline connected to the delivery pipeline of the distribution valve group, and the cleaning liquid flows out from the collection end to the cleaning tank assembly. The injection pump draws the cleaning liquid and flows out from the sampling end to the cleaning tank assembly;

[0027] The bypass valve group switches to the air supply system, and the dry air is delivered to the cleaning pool assembly through the bypass valve group, and the surfaces of the collecting end and the sampling end are purged and cleaned.

[0028] Compared with the prior art, the present invention has achieved the following technical effects:

[0029] The present invention uses a switching valve group and a distribution valve seat to switch to different communication paths, so that the collecting end can transport the distillate generated by the distillate solution generating device into the solvent bottle, and transport the distillate solution in the solvent bottle that has passed the inspection to the storage tank for storage. Through the cooperation of the injection pump and the sampling end, a set amount of distillate solution in the solvent bottle can be automatically sucked and transferred to the sample bottle for inspection; the automation of storage and sampling is realized, the pollution caused by manual sampling is avoided, and there is no need for manual lifting for transfer and storage, which improves work efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0031] Figure 1 Schematic diagram of the principle of a fraction collection and sampling system in one or some embodiments of the present invention;

[0032] Figure 2 Schematic diagram of the structure of a fraction collection and sampling system in one or some embodiments of the present invention;

[0033] Figure 3 Schematic diagram of the cleaning tank assembly structure of the fraction collection and sampling system in one or some embodiments of the present invention.

[0034] In the figure: 1-detection module, 2-switching valve group, 3-distribution valve group, 4-first delivery pump, 5-solvent bottle, 6-syringe pump, 7-sample bottle, 8-second delivery pump, 9-bypass valve group, 10-cleaning module, 11-switching valve, 12-base, 13-X-axis motor module, 14-X-axis slide, 15-Y-axis motor module, 16-cleaning tank assembly, 161-lower end cover, 162-connecting rod , 163-column, 164-upper end cover, 1641-channel hole, 165-sealing ring, 166-pressure plate, 167-diverter, 1671-injection hole, 168-sealing gasket, 169-drain pipe, 17-sampling end, 18-collecting end, 19-Z-axis slide, 20-Z-axis motor module, 21-Y-axis slide, 22-support seat, 23-solvent bottle tray, 24-sample bottle rack. DETAILED DESCRIPTION

[0035] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0036] The purpose of the present invention is to provide a fraction collection and sampling system and method to solve the problems existing in the above-mentioned prior art, reduce the risk of sample contamination, and have high working efficiency.

[0037] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0038] In conventional known industrial preparation fraction collection, the volume of the sample fraction collection container is usually large (solvent bottle in liters). When the collected samples need to be sampled and tested, they can only be sampled manually from the above large-volume solvent bottle, which not only increases the risk of sample contamination but also reduces work efficiency. Moreover, in the existing industrial preparation fraction collection scheme, after the sample sampling test in the solvent bottle is qualified, the fraction in the solvent bottle needs to be transferred and stored. Since the solvent bottle is large in volume and there are many solvent bottles, it is time-consuming and labor-intensive to transfer and store it by manual lifting, which further reduces work efficiency. In order to solve this problem, the present invention provides a fraction collection sampling system, such as Figure 1As shown, it includes a solvent bottle 5, a transfer module, a collection module and a sampling module. The solvent bottle 5 is used to temporarily store the distillate solution; the collection module includes a switching valve group 2 and a distribution valve group 3 connected by pipelines. The distribution valve group 3 is respectively connected to a storage pipeline and a delivery pipeline. The distribution valve group 3 can switch the delivery pipeline to be connected to the switching valve group 2 or the storage pipeline. The collecting end 18 at the end of the delivery pipeline can inject the distillate solution into the solvent bottle 5 or reversely absorb the distillate solution in the solvent bottle 5; the switching valve group 2 is connected to the distillate solution generating device, which is a mature and known structure in the prior art. The actual selection can be made according to the type of fraction, so it will not be elaborated on; the end of the storage pipeline is connected to a storage tank, which is a device in the prior art, and its interior is a closed structure, which can realize the storage of the fraction solution; the sampling module includes a sampling pipeline, and an injection pump 6 is provided on the sampling pipeline, and the injection pump 6 can be replaced by other forms of pump structures; and the sampling end 17 of the sampling pipeline can be extended into the solvent bottle 5 to take samples, and transfer the samples to the sample bottle 7; the transfer module is connected to the sampling end 17 and the collecting end 18 respectively, and can control the sampling end 17 and the collecting end 18 to move to the set positions respectively. A measuring module is provided between the distribution valve group 3 of the present invention and the distillate solution generating device. The measuring module of this embodiment is a flow meter, and a first delivery pump 4 is provided on the storage pipeline, which can provide power for delivering or extracting the distillate solution. The present invention adopts a switching valve group 2 and a distribution valve seat to switch to different communication paths, so that the collecting end 18 can deliver the distillate generated by the distillate solution generating device to the solvent bottle 5, and deliver the distillate solution in the solvent bottle 5 that has passed the inspection to the storage tank for storage. Through the cooperation of the injection pump 6 and the sampling end 17, the set amount of distillate solution in the solvent bottle 5 can be automatically sucked and transferred to the sample bottle 7 for inspection; the automation of storage and sampling is realized, the pollution caused by manual sampling is avoided, and there is no need for manual lifting for transfer and storage, which improves work efficiency.

[0039] In order to further avoid contamination of the distillate solution during sampling and collection, a cleaning module 10 is designed in one embodiment, which can clean the sampling end 17 and the collection end 18 after each sampling and collection of the distillate solution, so as to avoid the contamination of the distillate solution sampled next time by the dirt in the sampling end 17 and the collection end 18. The cleaning module of this embodiment includes a cleaning tank assembly 16, the bottom of the cleaning tank assembly 16 is connected to a sewage pipe 169, the upper part of the cleaning tank assembly 16 is connected to a bypass valve group 9, the bypass valve group 9 is connected to an air supply system and a cleaning liquid storage device at one end away from the cleaning tank assembly 16, and a second delivery pump 8 is provided between the cleaning liquid storage device and the bypass valve group 9 for extracting cleaning liquid and providing a certain pressure to the cleaning liquid entering the bypass valve group 9 so that the cleaning liquid can be sprayed out in the cleaning tank assembly 16; the cleaning liquid storage device can be used to A solution storage barrel or tank is used, containing a cleaning solution of known composition as described in the prior art. The air supply system includes an air pump, a dryer, and other structures, and may also employ an air compressor, both of which are known in the prior art and capable of generating dry compressed gas. Thus, a bypass valve assembly 9 is configured to introduce cleaning solution or dry gas into the cleaning tank assembly 16. A sampling port 17 and a collection port 18 are insertable into the cleaning tank assembly 16. A sampling line, remote from the sampling port 17, communicates with the cleaning solution storage device, and a switching valve assembly 2 communicates with the cleaning solution storage device via a branch line. The cleaning solution used in this embodiment is selected to be non-reactive or non-interfering with the sample solution, so residual cleaning solution will not contaminate the sample solution. The selection of cleaning liquid will not affect the composition of the sample solution. Therefore, after cleaning the sampling needle, collecting needle and the inner wall of the supporting pipeline, there is no need to dry the inner wall separately. Most of the cleaning liquid will flow out naturally along the sampling needle, collecting needle and the inner wall of the supporting pipeline. The small amount of residual cleaning liquid is compatible with the sample solution and will not react or interfere. Therefore, it will only cause a slight dilution of the sample solution sampled next time. The error caused by this slight dilution is allowed during the experiment. Therefore, after cleaning the sampling needle, collecting needle and the inner wall of the supporting pipeline, there is no need to worry about contamination of the sample solution taken next time. The composition of the cleaning liquid belongs to the existing technology, so it will not be elaborated.

[0040] After the distillate solution of the upstream distillate solution generating device is connected to the present invention, it first passes through the detection module 1 for different detection requirements. The detection module 1 of this embodiment adopts a flow meter; then it switches to the distribution valve group 3 through the switching valve group 2, and finally reaches the solvent bottle 5. After the distillate solution is collected in the solvent bottle 5, a small amount of the distillate solution in the solvent bottle 5 is extracted into the sampling pipeline through the injection pump 6 and the sampling pipeline (usually about 3 ml), and then the sampling end 17 is moved to the sample bottle 7, and then the injection pump 6 is reversed to pump it out into the sample bottle 7. At this time, the sampling step is completed. If the solution in the sample bottle 7 is qualified, the system enters the sample transfer and storage step, that is, the system uses the first delivery pump 4 to pump the sample in the corresponding qualified solvent bottle 5 into the storage tank through the distribution valve group 3.

[0041] During the above-mentioned sample collection and transfer process, the collecting end 18, the sampling end 17 and the related pipelines need to be cleaned and cleaned before the next step to avoid cross contamination of the samples. The specific method is as follows: the collecting end 18 is moved into the cleaning tank assembly 16, the switch valve 11 is closed, and the cleaning liquid is sprayed into the cleaning tank assembly 16 through the second delivery pump 8 and the bypass valve group 9 until the cleaning tank assembly 16 is filled. This step is a preliminary cleaning of the outer surface of the collecting end 18 and the sampling end 17 inserted in the cleaning tank assembly 16. After the preliminary cleaning is completed, the switch valve 11 is opened to discharge the waste liquid in the cleaning tank assembly 16. At the same time, the collecting end 18 achieves the purpose of cleaning the entire outer wall by moving up and down in the cleaning tank assembly 16. When cleaning the outer wall of the collecting end 18, the sampling end 17 and the inner wall of the sampling pipeline are also sucked into the sampling pipeline by the suction action of the injection pump 6, and flow out from the sampling end 17 to the cleaning tank assembly 16, thereby achieving the function of flushing the pipeline and the inner wall of the sampling end 17; the branch pipeline of the switching valve group 2 is connected to the cleaning liquid storage device, and the switching valve group 2 is switched to the branch pipeline connected to the distribution valve group 3. At this time, the cleaning liquid in the cleaning liquid storage device is extracted by the first delivery pump 4, which can realize the function of cleaning the inner wall of the collecting end 18 and the delivery pipeline. This cleaning process is the same as the cleaning process of the inner wall of the sampling end 17. After the inner and outer walls of the pipeline are flushed with the cleaning liquid, the outer walls of the sampling end 17 and the collecting end 18 will be purged and cleaned by compressed air to reduce the situation of dripping on the wall and the impact on the next sampling test. The specific steps are that the compressed air reaches the corresponding air outlet of the cleaning tank assembly 16 through the bypass valve group 9, and the collecting end 18 and the sampling end 17 move up and down through the air outlet position to achieve the purpose of purging. The switching valve group 2, the distribution valve group 3 and the bypass valve group 9 of the present invention are all valve group structures in the prior art, and each has the function of a three-way valve, which can be switched to any two passages as needed. The specific principles and functions are prior art, so they will not be repeated; in one embodiment, the switching valve group 2, the distribution valve group 3 and the bypass valve group 9 can also be replaced by a three-way valve or other solenoid valve structure with a passage switching function.

[0042] like Figure 3 As shown, in one embodiment, the cleaning module 10 includes a cleaning pool assembly 16, and the cleaning pool assembly 16 includes a column 163 with a hollow interior and open ends. The column 163 of this embodiment is made of glass. The top of the column 163 is fixedly and sealedly connected to an upper end cover 164, and the bottom of the column 163 is fixedly and sealedly connected to a lower end cover 161. A plurality of connecting rods 162 are arranged around the outside of the column 163, and one end of the connecting rod 162 is fixedly connected to the upper end cover 164, and the other end of the connecting rod 162 is fixedly connected to the lower end cover 161. The bottom of the lower end cover 161 is fixedly and sealedly connected to the upper end cover 164. The upper end cover 164 is connected to a sewage pipe 169, on which a switch valve 11 is provided; a diverter 167 is fixedly provided in the upper end cover 164, and a through hole is provided in the diverter 167, for inserting the sampling end 17 and / or the collecting end 18; a channel hole 1641 is provided in the side wall of the upper end cover 164, one end of the channel hole 1641 is connected to the bypass valve group 9, and the other end is connected to the diverter 167, and a plurality of injection holes 1671 are arranged on the side wall of the diverter 167, which can spray cleaning liquid or dry gas into the cleaning tank assembly 16. A sealing gasket 168 is provided at the connection position between the upper end cover 164 and the column 163, and a sealing gasket 168 is provided at the connection position between the lower end cover 161 and the column 163; a pressure plate 166 is fixedly provided on the top of the upper end cover 164, and a diverter 167 is provided at the bottom of the pressure plate 166, and a through hole coaxial with the through hole is opened on the pressure plate 166; the sampling end 17 and the collecting end 18 can pass through the through hole and the through hole in turn to enter the column 163; two sealing rings 165 are provided at the connection position between the outer side of the diverter 167 and the inner side of the upper end cover 164, and the sealing rings 165 are respectively located above and below the channel hole 1641.

[0043] The upper end cap 164 of this embodiment has two channel openings on its side. These channel openings serve as pipeline interfaces and can be connected to the bypass valve assembly 9 to deliver cleaning fluid and compressed air, respectively. The diverter 167 has multiple obliquely arranged spray holes 1671 circumferentially for spraying cleaning fluid and compressed air into the column 163 in all directions. The sampling end 17 and the collecting end 18 extend into the column 163. Simultaneously, the cleaning fluid passes through the second delivery pump 8 into the bypass valve assembly 9, then through the upper end cap 164 into the diverter 167, and is ejected from the spray holes 1671 to clean the outer walls of the sampling end 17 and the collecting end 18. The inner walls of the pipeline and the inner walls of the sampling end 17 and the collecting end 18 are cleaned simultaneously. Specifically, the cleaning fluid enters the sampling end 17 through the injection pump 6; and the cleaning fluid enters the distribution valve assembly 3 through the switching valve assembly 2, and then enters the collecting end 18. After the inner and outer walls are cleaned with the cleaning liquid, the sampling end 17 and the collecting end 18 move upward. At the same time, the compressed air enters the upper end cover 164 through the bypass valve group 9, and then enters the diverter 167, and is sprayed out from the injection hole 1671 to blow away the droplets on the outer walls of the sampling end 17 and the collecting end 18 to prevent liquid from hanging on the outer wall.

[0044] like Figure 2 As shown, in one embodiment, the fraction collection and sampling system of the present invention includes a base 12, a transfer module and a cleaning tank assembly 16 are both arranged on the base 12, a solvent bottle tray 23 and a sample bottle rack 24 are fixedly provided on the base 12, a plurality of solvent bottles 5 are evenly arranged on the solvent bottle tray 23, and a plurality of sample bottles 7 are fixedly provided on the sample bottle rack 24.

[0045] The transfer module in this embodiment includes a support base 22 arranged on the base 12, and a first translation module is provided on the support base 22, and a second translation module is movably connected to the first translation module, and a vertical movement module is provided on the second translation module, and the vertical movement module is connected to the sampling end 17 and the collecting end 18; the second translation module can move horizontally along the first translation module, and the vertical movement module can move horizontally along the second translation module, and the moving direction of the vertical movement module is perpendicular to the moving direction of the second translation module; the sampling end 17 and the collecting end 18 can move up and down respectively along the vertical movement module. The specific structures of the first translation module, the second translation module and the vertical movement module are not limited. In one embodiment, the first translation module can adopt a slide rail horizontally arranged on the support seat 22, and a slider is provided on the slide rail. The second translation module is fixedly connected to the slider, and the slider is connected to a screw nut pair, which can realize the function of driving the slider to move horizontally along the slide rail; the structure of the second translation module is the same as the first translation module. The second translation module is arranged vertically to the first translation module, and the slide rail of the second translation module is fixed on the slider of the first translation module. A vertical movement module is provided on the slider of the second translation module, so as to realize the horizontal X and Y movement of the vertical movement module, and the vertical movement module includes a vertical slide rail, which is provided on the slider of the second translation module, and a vertical slider is provided on the vertical slide rail. The vertical slider is connected to a vertically arranged screw nut pair, so as to realize the up and down movement of the vertical slider, and a sampling end 17 and a collecting end 18 are provided on the vertical slider. In another embodiment, the transfer module may also adopt a mature robot structure, and the robot can drive the collecting end 18 and the sampling end 17 to move to the set position.

[0046] In a preferred embodiment, Figure 2As shown, two symmetrical support seats 22 are provided on the base 12, and an X-direction motor module 13 is installed on each support seat 22. The X-direction motor module 13 is provided with an X-direction slide 14, and the X-direction motor module 13 can drive the X-direction slide 14 to move horizontally along the X-direction. The X-direction slide 14 is provided with a Y-direction motor module 15, and the Y-direction motor module 15 is provided with a Y-direction slide 21, and the Y-direction motor module 15 can drive the Y-direction slide 21 to move horizontally along the Y-direction. The Y-direction slide 21 is provided with two Z-direction motor modules 20, and the two Z-direction motor modules 20 are respectively connected to independent Z-direction slides 19, and the two Z-direction slides 19 are respectively installed with vertically arranged sampling ends 17 and collecting ends 18. The sampling end 17 or the collecting end 18 can be driven to move up and down along the Z direction through their respective Z-direction motor modules 20. The injection pump 6, the switching valve group 2, and the distribution valve group 3 are fixedly mounted on the Y-direction slide 21. The bypass valve group 9 is fixedly mounted on the base 12. The solvent bottle tray 23 and the sample bottle rack 24 are placed in the corresponding grooves of the base 12. The solvent bottle 5 is placed in the solvent bottle tray 23. The sample bottle 7 is placed in the sample bottle rack 24. The cleaning pool assembly 16 is fixedly mounted on the base 12. The first delivery pump 4, the second delivery pump 8, and the flow meter are installed below the base 12.

[0047] The two X-motor modules 13 operate synchronously to drive the Y-motor module 15 forward and backward in the X direction. The Y-motor module 15 drives the two Z-motor modules 20 left and right in the Y direction. The two Z-motor modules 20 respectively drive the sampling end 17 and the collection end 18 to independently move up and down in the Z direction. Through this movement, the sampling end 17 and the collection end 18 can freely switch between the solvent bottle 5, the sample bottle 7, and the cleaning tank assembly 16.

[0048] When collecting the fraction solution: the collecting end 18 moves to the corresponding solvent bottle 5, and the fraction solution passes through the flow meter. Switching valve group 2 Distribution valve group 3 Collection end 18 The solvent bottle 5, the switching valve group 2 and the distribution valve group 3 all have three-way valve functions, and the communication path can be selected as needed. The details are not described here. After the collection is completed, the collection end 18 is moved to the cleaning tank assembly 16 for cleaning as appropriate.

[0049] To transfer the fraction solution, the sampling tip 17 is moved to the solvent bottle 5 to be tested. The solution is then pumped into the pipeline by the syringe pump 6. The sampling tip 17 is then moved to the mouth of the corresponding sample bottle 7. The syringe pump 6 rotates in reverse to push the sample in the pipeline into the sample bottle 7. Finally, the sample bottle 7 on the sample bottle rack 24 is tested. After the sample transfer is completed, the sampling tip 17 is moved to the cleaning tank assembly 16 for cleaning in preparation for the next sampling.

[0050] When the fraction solution is transferred: when the solution in the sample bottle 7 is tested and qualified in the previous step, the solution in the corresponding solvent bottle 5 is transferred and stored through the following steps: the collecting end 18 is moved to the bottom of the corresponding solvent bottle 5, and the solution is transferred through the collecting end 18 Distribution valve group 3 First delivery pump 4 In this embodiment, the collecting end 18 is a collecting needle, and the sampling end 17 is a sampling needle.

[0051] The present invention also provides a fraction collection and sampling method, comprising the following steps:

[0052] The distribution valve group 3 is switched to connect the delivery pipeline with the switching valve group 2. The distillate solution of the distillate solution generating device flows through the switching valve group 2 to the distribution valve group 3, enters the delivery pipeline, and is then delivered to the solvent bottle 5 through the collecting end 18.

[0053] The sampling end 17 is inserted into the solvent bottle 5, and the syringe pump 6 is started to draw a set amount of distillate solution in the solvent bottle 5 into the sampling end 17; then the sampling end 17 is moved into the sample bottle 7, and the syringe pump 6 is reversed to pump the set amount of distillate solution in the sampling end 17 out into the sample bottle 7;

[0054] The solution in the sample bottle 7 is tested. If the test result is qualified, the distribution valve group 3 is switched to connect the delivery pipeline with the storage pipeline, and the distillate solution in the solvent bottle 5 carrying the qualified solution is pumped into the storage tank.

[0055] The cleaning steps of this embodiment include:

[0056] The collecting end 18 and the sampling end 17 are respectively moved into the cleaning tank assembly 16, the switch valve 11 is closed, and the cleaning liquid is transported to the cleaning tank assembly 16 through the bypass valve group 9, and the surfaces of the collecting end 18 and the sampling end 17 are sprayed and cleaned until the cleaning liquid fills the cleaning tank assembly 16;

[0057] The switch valve 11 is opened to discharge the cleaning fluid in the cleaning tank assembly 16;

[0058] The switching valve group 2 switches to a branch pipeline connected to the delivery pipeline of the distribution valve group 3, and the cleaning liquid flows out through the collection end 18 into the cleaning tank assembly 16. The injection pump 6 extracts the cleaning liquid and flows out from the sampling end 17 into the cleaning tank assembly 16;

[0059] The bypass valve group 9 is switched to the air supply system, and the dry air is delivered to the cleaning tank assembly 16 through the bypass valve group 9, and the surfaces of the collecting end 18 and the sampling end 17 are purged and cleaned.

[0060] The present invention uses specific examples to illustrate the principles and implementation methods of the present invention. The above examples are only intended to help understand the method and core concept of the present invention. At the same time, those skilled in the art will find that the specific implementation methods and application scopes may vary based on the concept of the present invention. In summary, the contents of this specification should not be construed as limiting the present invention.

Claims

1. A fraction collection and sampling system, characterized in that: include: Solvent bottle, used to temporarily store distillate solution; The collection module includes a switching valve group and a distribution valve group connected by pipelines. The distribution valve group is respectively connected to a storage pipeline and a delivery pipeline. The distribution valve group can switch the delivery pipeline to communicate with the switching valve group or the storage pipeline. The collection end at the end of the delivery pipeline can inject the distillate solution into the solvent bottle or reversely absorb the distillate solution in the solvent bottle; the switching valve group is connected to the distillate solution generating device, and the end of the storage pipeline is connected to a storage tank; The sampling module comprises a sampling pipeline, wherein the sampling pipeline is provided with a syringe pump, and the sampling end of the sampling pipeline is capable of extending into the solvent bottle to take a sample and transfer the sample into the sample bottle; The transfer module is connected to the sampling end and the collecting end respectively, and can control the sampling end and the collecting end to move to the set positions respectively.

2. The fraction collection and sampling system according to claim 1, characterized in that: It also includes a cleaning module, which includes a cleaning tank assembly, the bottom of the cleaning tank assembly is connected to a sewage pipeline, the upper part of the cleaning tank assembly is connected to a bypass valve group, the bypass valve group is connected to an air supply system and a cleaning liquid storage device at one end away from the cleaning tank assembly, and the bypass valve group can respectively introduce cleaning liquid or dry gas into the cleaning tank assembly; the sampling end and the collecting end can be inserted into the cleaning tank assembly; the sampling pipeline is connected to the cleaning liquid storage device away from the sampling end, and the switching valve group is connected to the cleaning liquid storage device through a branch pipeline.

3. The fraction collection and sampling system according to claim 2, characterized in that: The cleaning pool assembly includes a column cylinder with a hollow interior and openings at both ends, the top of the column cylinder is fixedly and sealedly connected to an upper end cover, the bottom of the column cylinder is fixedly and sealedly connected to a lower end cover, the bottom of the lower end cover is connected to the sewage pipe, and the sewage pipe is provided with a switch valve; a diverter is fixedly provided in the upper end cover, and a through hole is provided on the diverter, and the through hole is used to insert the sampling end and / or the collecting end; a channel hole is provided on the side wall of the upper end cover, one end of the channel hole is connected to the bypass valve group, and the other end is connected to the diverter, and a plurality of injection holes are arranged on the side wall of the diverter, and the injection holes can spray cleaning liquid or dry gas into the cleaning pool assembly.

4. The fraction collection and sampling system according to claim 3, characterized in that: It also includes connecting rods, a plurality of connecting rods are arranged around the outside of the column, and one end of the connecting rod is fixedly connected to the upper end cover, and the other end of the connecting rod is fixedly connected to the lower end cover.

5. The fraction collection and sampling system according to claim 3, characterized in that: A sealing gasket is provided at the connection position between the upper end cover and the column barrel, and the sealing gasket is provided at the connection position between the lower end cover and the column barrel; a pressure plate is fixedly provided on the top of the upper end cover, the diverter is provided at the bottom of the pressure plate, and a through hole coaxial with the through hole is opened on the pressure plate; the sampling end and the collecting end can pass through the through hole and the through hole in sequence to enter the column barrel; two sealing rings are provided at the connection position between the outer side of the diverter and the inner side of the upper end cover, and the sealing rings are respectively located above and below the channel hole.

6. The fraction collection and sampling system according to claim 2, characterized in that: It also includes a base, the transfer module and the cleaning pool assembly are both arranged on the base, a solvent bottle tray and a sample bottle rack are fixedly provided on the base, a plurality of solvent bottles are evenly arranged on the solvent bottle tray, and a plurality of sample bottles are fixedly provided on the sample bottle rack.

7. The fraction collection and sampling system according to claim 6, characterized in that: The transfer module includes a support seat arranged on the base, a first translation module is provided on the support seat, a second translation module is movably connected to the first translation module, a vertical movement module is provided on the second translation module, and the sampling end and the collecting end are connected to the vertical movement module; the second translation module can move horizontally along the first translation module, the vertical movement module can move horizontally along the second translation module, and the moving direction of the vertical movement module is perpendicular to the moving direction of the second translation module; the sampling end and the collecting end can move up and down respectively along the vertical movement module.

8. The fraction collection and sampling system according to claim 2, characterized in that: A flow meter is provided between the distribution valve group and the distillate solution generating device, a first delivery pump is provided on the storage pipeline, and a second delivery pump is provided between the cleaning liquid storage device and the bypass valve group.

9. A fraction collection and sampling method, characterized in that: The steps include: The distribution valve group is switched to the delivery pipeline and connected to the switching valve group. The distillate solution of the distillate solution generating device flows through the switching valve group to the distribution valve group, enters the delivery pipeline, and is then delivered to the solvent bottle through the collecting end. The sampling tip is inserted into the solvent bottle, the syringe pump is started, and the set amount of distillate solution in the solvent bottle is sucked into the sampling tip; then the sampling tip is moved into the sample bottle, and the syringe pump is reversed to pump the set amount of distillate solution in the sampling tip into the sample bottle; The solution in the sample bottle is tested. If the test result is qualified, the distribution valve group is switched to connect the delivery pipeline with the storage pipeline, and the distillate solution in the solvent bottle containing the qualified solution is pumped into the storage tank.

10. The fraction collection and sampling method according to claim 9, characterized in that: Also included is a cleaning step, the cleaning step comprising: The collecting end and the sampling end are respectively moved into the cleaning tank assembly, the switch valve is closed, and the cleaning liquid is transported to the cleaning tank assembly through the bypass valve group, and the surfaces of the collecting end and the sampling end are sprayed and cleaned until the cleaning liquid fills the cleaning tank assembly; Open the switch valve to drain the cleaning fluid in the cleaning tank assembly; The switching valve group switches to the branch pipeline connected to the delivery pipeline of the distribution valve group, and the cleaning liquid flows out from the collection end to the cleaning tank assembly. The injection pump draws the cleaning liquid and flows out from the sampling end to the cleaning tank assembly; The bypass valve group switches to the air supply system, and the dry air is delivered to the cleaning pool assembly through the bypass valve group, and the surfaces of the collecting end and the sampling end are purged and cleaned.

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