A device for detecting urea nitrogen and creatinine content in hemodialysis solution

Abstract

The present application belongs to the technical field of hemodialysis detection, and particularly relates to a device for detecting urea nitrogen and creatinine content in hemodialysis solution, which comprises a shunt connected to a liquid pipeline of a dialyzer, and further comprises a communication pipe mounted on the shunt, a support ring formed at the bottom of the communication pipe, a rubber plug mounted on the support ring, a detection cylinder connected to the bottom of the communication pipe, a sampling sealing mechanism arranged in the detection cylinder, a rotating disc movably arranged in the detection cylinder, a sealing disc, a needle cylinder mounted on the sealing disc, wherein the sealing disc is rotatably attached to the bottom surface of the rubber plug, a sampler is detachably mounted on the rotating disc, a shunt plug is detachably connected to the sampler, the shunt plug is communicated with a plurality of detection boxes through a flow guide pipe, the plurality of detection boxes are placed on the rotating disc, and a detection test paper is placed in each detection box. The present application can realize "bedside rapid detection", and meet the needs of real-time monitoring and immediate evaluation of dialysis adequacy during dialysis.

Description

Technical Field

[0001] This invention belongs to the field of hemodialysis detection technology, and in particular relates to a device for detecting the content of urea nitrogen and creatinine in hemodialysis fluid. Background Technology

[0002] Urea is a major end product of protein metabolism in the human body. Deamination of amino acids produces NH3 and CO2, which are then synthesized into urea in the liver. Approximately 0.3 grams of urea nitrogen are produced per gram of protein metabolism. The kidneys are the primary organs for urea excretion; after filtration by the glomeruli, urea can be reabsorbed in various segments of the tubules.

[0003] Creatinine (CR) is a product of muscle metabolism in the human body. It is mainly formed slowly from creatine through an irreversible non-enzymatic dehydration reaction, and then released into the bloodstream and excreted in urine. It is not easily affected by diet and can be filtered by the glomerulus. It is rarely reabsorbed in the renal tubules. Creatinine includes serum creatinine and urine creatinine. Serum creatinine is more meaningful in measuring kidney function. The measurement of serum creatinine concentration is an effective indicator for evaluating glomerular filtration rate and can effectively reflect the degree of substantial damage to kidney function. Clinically, detection is helpful in judging the condition and has important significance.

[0004] When performing hemodialysis on uremia patients, a dialyzer is required. To monitor the adequacy of hemodialysis by the dialyzer, changes in blood urea nitrogen and creatinine levels after dialysis are detected either by drawing blood or by monitoring changes in urea nitrogen and creatinine levels in the hemodialysis dialysate. This allows for the timely detection of dialyzer damage. For example, if the hollow fiber membrane of the dialyzer is damaged, the urea nitrogen content in the dialysate will increase significantly. Detection can help identify dialyzer damage in a timely manner, allowing for prompt treatment and preventing accidents.

[0005] Existing methods for detecting urea nitrogen and creatinine levels in the blood, whether through blood sampling or by detecting changes in urea nitrogen and creatinine levels in hemodialysis fluid, require medical staff to send the drawn blood samples or collected hemodialysis fluid samples to the laboratory for testing. This method not only fails to achieve "rapid bedside testing" and meet the needs of real-time monitoring and immediate assessment of dialysis adequacy during dialysis. Summary of the Invention

[0006] To solve the above-mentioned technical problems, the present invention is achieved through the following technical solution:

[0007] This invention relates to a device for detecting urea nitrogen and creatinine content in hemodialysis fluid, comprising a shunt tube connected to the dialyzer fluid pipeline; further comprising: a connecting tube detachably mounted to the shunt tube, wherein a support ring is formed at the bottom of the connecting tube and the support ring is fitted to the bottom of the shunt tube, and a rubber stopper is mounted on the support ring; a detection cylinder is connected to the bottom of the connecting tube, and a sampling sealing mechanism is provided inside the detection cylinder; the sampling sealing mechanism includes a turntable movably placed inside the detection cylinder, a sealing disc connected to the turntable via a shaft, and a syringe mounted on the sealing disc; wherein the sealing disc rotates to fit against the bottom surface of the rubber stopper, and a sampler is detachably mounted on the turntable; a shunt plug is detachably connected to the sampler, and the shunt plug is connected to several detection boxes via a guide tube, and several detection boxes are placed on the turntable, and each detection box contains a test strip.

[0008] Furthermore, the sampling sealing mechanism further includes: a bottom circular plate, placed at the bottom of the detection cylinder, and a motor for driving the shaft to rotate is fixed in the middle of the bottom circular plate; a support ring, rotatably placed on the bottom circular plate; a first electric push rod, fixedly placed on the support ring, and the output rod of the first electric push rod is connected to the turntable; a suspension ring, fixedly placed on the sealing disc, and the suspension ring is rotatably connected to the support ring; and a strip block, the strip block being vertically placed on the shaft, and the strip block engaging with a keyway opened in the center hole of the turntable.

[0009] Furthermore, the sampler includes: a support slot, which is formed through the turntable, with the slot opening facing the outer ring of the turntable and located directly below the syringe; a sampling cylinder, which is movably inserted into the support slot, and a limiting ring that cooperates with the support slot is fixed on the cylinder wall; a tubular needle, which is placed on the top of the sampling cylinder, and the needle tip of the tubular needle is aligned with the syringe; a piston, which is movably placed inside the sampling cylinder, and a limiting block is provided at the bottom of the piston rod of the piston; and a second electric push rod, which is vertically fixed on the bottom surface of the turntable, and the output rod end of the second electric push rod is in a downward state.

[0010] And a docking block, which is placed at the end of the output rod of the second electric push rod, and the docking block is provided with a T-shaped slot that cooperates with the limiting block.

[0011] Furthermore, a sealing plug of the same material as the rubber plug is installed on the top of the diverter plug, a diverter cavity is formed inside the diverter plug, and the diverter cavity is connected to the guide tube. The sealing plug is squeezed and inserted into the bottom opening of the syringe.

[0012] Furthermore, a first spring is provided on the upper surface of the limiting ring located at the slot of the support groove. The first spring is sleeved on the sampling cylinder, and the top of the first spring is detachably connected to the diverter plug.

[0013] Furthermore, a bent piece is provided on the top spiral ring of the first spring member, and the vertical piece of the bent piece is movably inserted into the insertion groove opened on the diverter plug. A pin hole is formed on the side wall of the insertion groove, which is aligned with the through hole formed on the bent piece, and a pin is inserted into the pin hole.

[0014] A limiting rod is vertically arranged on the horizontal piece of the bent sheet, and the bottom end of the limiting rod moves downward through two limiting support rings to connect with a limiting block.

[0015] Furthermore, the detection cylinder is movably sleeved on the bottom circular plate, and the inner wall of the detection cylinder is provided with a vertical guide bar that cooperates with the guide notch opened on the bottom circular plate. The upper opening of the detection cylinder is connected to the connecting pipe through a fastening assembly.

[0016] Furthermore, the fastening assembly includes: a support base, with several circumferentially arranged on the outer circumferential surface of the upper opening of the detection cylinder; a fastening rod, movably inserted into the support base, with the bottom of the fastening rod connected to the support base via a second spring; a locking block, with several circumferentially arranged on the outer wall of the connecting pipe, and a locking notch provided on the locking block; a rotating head, rotatably mounted to the top of the fastening rod via a rotating rod; and a fastening block fixed to the rotating head.

[0017] When the fastening rod passes upward through the engaging notch, the fastening block rotates and fits against the upper surface of the latching block.

[0018] The present invention has the following beneficial effects:

[0019] This solution ingeniously integrates the detection device into the dialyzer's liquid pipeline, enabling real-time sampling and testing of the dialysate flowing in the waste discharge pipeline. It eliminates the need for medical staff to draw blood for testing, thus achieving "rapid bedside testing" and meeting the needs for real-time monitoring and immediate assessment of dialysis adequacy during the dialysis process.

[0020] The detachable sampler, rotating turntable, and sealing plate inside the testing cylinder work together. The synchronous rotation of the turntable and sealing plate can drive the sampler and syringe to different positions on the rubber stopper. This allows the tubular needles of multiple samplers to puncture different positions on the rubber stopper, effectively preventing the needle holes on the rubber stopper from failing to close freely due to multiple needles puncturing the same position, which could easily lead to leakage of the dialysate flowing in the waste discharge pipeline. When the sealing plate drives the syringe to the next puncture point, the seal between the sealing plate and the rubber stopper provides a secondary seal, preventing the needle holes on the rubber stopper from closing loosely and causing secondary leakage.

[0021] Of course, any product implementing this invention does not necessarily need to achieve all of the advantages described above at the same time. Attached Figure Description

[0022] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0023] Figure 1 This is a schematic diagram of the waste discharge pipeline assembly of the detection device and dialyzer according to an embodiment of the present invention;

[0024] Figure 2 This is a diagram showing the open state of the detection cylinder according to an embodiment of the present invention;

[0025] Figure 3 This is a schematic diagram of the internal structure of the detection cylinder according to an embodiment of the present invention;

[0026] Figure 4 This is a schematic diagram of the sampling and sealing mechanism according to an embodiment of the present invention;

[0027] Figure 5 This is a schematic diagram of the sampler according to an embodiment of the present invention;

[0028] Figure 6 This is an exploded view of the assembly of the tubular needle and the flow divider according to an embodiment of the present invention;

[0029] Figure 7 This is a cross-sectional view of the rubber stopper according to an embodiment of the present invention;

[0030] Figure 8 The present invention discloses an embodiment of the invention. Figure 7 Enlarged view of a portion of point A in the middle.

[0031] In the diagram: 1. Diverter tube; 2. Connecting tube; 21. Support ring; 3. Rubber plug; 4. Detection cylinder; 5. Sampling sealing mechanism; 51. Turntable; 511. Support groove; 52. Shaft; 53. Sealing disc; 54. Syringe; 55. Bottom circular plate; 56. Support rotating ring; 57. First electric push rod; 58. Suspension ring; 59. Strip block; 6. Sampler; 61. Sampling cylinder; 62. Limiting support ring; 3. Tubular needle; 64. Piston component; 65. Second electric push rod; 66. Limiting block; 67. Connecting block; 68. First spring component; 69. Limiting rod; 691. Bending piece; 7. Diverter plug; 71. Diverter cavity; 72. Sealing plug; 73. Guide tube; 8. Detection box; 9. Fastening assembly; 91. Support base; 92. Fastening rod; 93. Snap-on block; 94. Rotating head; 95. Fastening block. Detailed Implementation

[0032] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0033] In the description of this invention, it should be understood that the terms "opening", "upper", "lower", "thickness", "top", "middle", "length", "inner", "around", etc., which indicate orientation or positional relationship, are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the components or elements referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as limiting this invention.

[0034] Please see Figures 1-8 As shown, the present invention is a device for detecting the content of urea nitrogen and creatinine in hemodialysis dialysate, including a shunt pipe 1 connected to the dialyzer liquid pipeline; and further including:

[0035] A connecting pipe 2 is installed onto the shunt pipe 1 via a threaded connection. The bottom of the connecting pipe 2 is integrally formed with a support ring 21, which fits snugly against the bottom of the shunt pipe 1. A rubber stopper 3 is installed on the support ring 21. Preferably, the rubber stopper 3 is made of butyl rubber (a common sealing material for infusion bottles), which possesses excellent elasticity and toughness, and its material design can withstand physical friction during puncture. Modern needles employ bevel cutting technology, achieving a seal through physical compression rather than direct puncture during puncture, reducing the shedding of rubber fragments.

[0036] The bottom of the connecting pipe 2 is connected to a detection cylinder 4, and a sampling sealing mechanism 5 is provided inside the detection cylinder 4;

[0037] The sampling sealing mechanism 5 includes a turntable 51 movably placed inside the detection cylinder 4, a sealing disc 53 connected to the turntable 51 via a shaft 52, and a syringe 54 mounted on the sealing disc 53.

[0038] The sealing disk 53 is rotated to fit against the bottom surface of the rubber stopper 3, and a sampler 6 is detachably installed on the turntable 51.

[0039] The sampler 6 is detachably connected to a flow divider 7, and the flow divider 7 is connected to several test boxes 8 through a flow guide tube 73. Several test boxes 8 are placed on the turntable 51, and each test box 8 contains a test strip.

[0040] As a preferred embodiment of this scheme, taking the detection of changes in urea nitrogen and creatinine content in hemodialysis dialysate as an example:

[0041] The detection device is assembled by first connecting the shunt tube 1 to the dialysate waste discharge line of the dialyzer, and then connecting the connecting tube 2 to the shunt tube 1 by threading. At this time, the rubber stopper 3 will be squeezed and inserted into the shunt tube 1 to seal the shunt tube 1. At this time, the detection cylinder 4 can be detachably installed to the waste discharge line of the dialyzer through the bottom circular plate 55. When the dialyzer is performing normal dialysis on the patient's blood, the dialysate produced will be transported to the waste collection tank through the waste discharge line. At this time, due to the sealing of the shunt tube 1 by the rubber stopper 3, the dialysate flowing in the waste discharge line will not enter the detection cylinder 4.

[0042] Dialysis fluid sampling: When it is necessary to periodically test the urea nitrogen and creatinine content in the produced dialysate, the operator first opens the test cylinder 4 and installs the sampler 6 (which can be a disposable or reusable medical product) onto the turntable 51. At this time, the shunt plug 7 will be simultaneously positioned directly below the syringe 54. Several test boxes 8 can be installed onto the turntable 51 using Velcro. Then, the turntable 51 is controlled to rise within the test cylinder 4, causing the sampler 6 to partially seal and insert into the test cylinder 4 along with the shunt plug 7. As the turntable 51 continues to rise within the test cylinder 4, the tubular needle 63 on the sampler 6 will sequentially pass through the shunt plug 7 and the syringe 54 and insert into the rubber stopper 3. Then, the beveled tip of the tubular needle 63 will pass through the rubber stopper 3. The rubber stopper 3 is connected to the waste discharge pipeline, and the sampler 6 will draw and collect the dialysate flowing in the waste discharge pipeline. When the sampler 6 has drawn a certain amount of dialysate, the turntable 51 will move away from the sealing plate 53 in the detection cylinder 4, so that the tubular needle 63 of the sampler 6 will withdraw from the rubber stopper 3. At this time, the rubber stopper 3 will continue to be sealed (because the tubular needle 63 enters the rubber stopper 3 by physical compression rather than direct puncture, the hole formed on the rubber stopper 3 will restore the seal according to its own elasticity and toughness). When the needle tip of the tubular needle 63 retracts into the shunt plug 7, the upper part of the shunt plug 7 is made of a material similar to that of the rubber stopper 3. Therefore, the upper part of the shunt plug 7 will seal the cavity formed inside the shunt plug 7.

[0043] Dialysis fluid detection: After the sampler 6 takes a quantitative amount of dialysis fluid, the turntable 51 is stationary in the detection cylinder 4. The sampler 6 continues to work and will transport the extracted dialysis fluid through the split plug 7 and the bifurcated guide tube 73 to several detection boxes 8 (taking 3 detection boxes 8 in the figure as an example). Since each detection box 8 contains a test strip (preferably a urease-ammonia colorimetric test strip, the principle is: the test strip contains immobilized urease, which catalyzes the decomposition of urea in the dialysis fluid into ammonia. The ammonia reacts with the colorimetric reagent (such as phenol red, bromothymol blue), and the quantitative result is obtained through color change), when the dialysis fluid flows in the guide tube 73, some of the gas in the guide tube 73 will be discharged through the exhaust port of the detection box 8, so that it will not interfere with the normal detection of the test strip.

[0044] Test results: After the test paper in the test box 8 has been left to stand for a certain period of time, the test tube 4 is opened, and several test boxes 8 are removed from the turntable 51. The urea nitrogen concentration corresponding to the color level is read by comparing the test box 8 with the standard color chart through the observation window.

[0045] When it is necessary to test the urea nitrogen and creatinine content of the dialysate produced during dialyzer operation again, the sampler 6, shunt plug 7, guide tube 73, and test box 8 used must first be removed from the test tube 4. If the above devices are all made of medical-grade and reusable materials, they must be sterilized first (to remove ammonia residue). If they are disposable medical products, they should be placed directly into the medical waste bin. Then, the sterilized sampler 6 and other devices (or newly opened sampler 6 and other devices) should be reinstalled on the turntable 51, and then the test tube should be... 4. When the rated time is reached and the dialysate needs to be sampled and tested again, the sampling sealing mechanism 5 can drive the turntable 51 to rotate inside the detection cylinder 4, so that it drives the sampler 6, sealing plate 53 and syringe 54 to rotate to be misaligned with a needle puncture site on the rubber stopper 3. At this time, the operator controls the sampling sealing mechanism 5 to work through the handheld control terminal or the control panel on the detection cylinder 4, so that the flowing dialysate can be sampled and tested multiple times, thereby improving the accuracy and efficiency of detecting changes in urea nitrogen and creatinine content in hemodialysis dialysate.

[0046] This solution ingeniously integrates the detection device into the dialyzer's liquid pipeline, enabling real-time sampling and testing of the dialysate flowing in the waste discharge pipeline. It eliminates the need for medical staff to draw blood for testing, thus achieving "rapid bedside testing" and meeting the needs for real-time monitoring and immediate assessment of dialysis adequacy during the dialysis process.

[0047] The sampler 6, rotating turntable 51, and sealing disc 53 detachably installed inside the detection cylinder 4 work together. The synchronous rotation of the turntable 51 and sealing disc 53 can drive the sampler 6 and syringe 54 to rotate to different positions of the rubber stopper 3, allowing the tubular needles 63 of multiple samplers 6 to puncture different positions of the rubber stopper 3. This effectively avoids the phenomenon that the needle hole formed on the rubber stopper 3 cannot close freely due to multiple tubular needles 63 puncturing the same position, which could easily lead to leakage of the dialysate flowing in the waste discharge pipeline. When the sealing disc 53 drives the syringe 54 to the next puncture point, the sealing disc 53 and the rubber stopper 3 are in contact, which can play a secondary sealing role on the rubber stopper 3, preventing the needle hole formed on the rubber stopper 3 from closing loosely and causing secondary leakage.

[0048] See Figures 2 to 4As shown, the sampling sealing mechanism 5 further includes: a bottom circular plate 55, placed at the bottom of the detection cylinder 4, and a motor for driving the shaft 52 to rotate is fixed in the middle of the bottom circular plate 55; a support ring 56, rotatably placed on the bottom circular plate 55; at least two first electric push rods 57, fixedly placed on the support ring 56, and the output rod of the first electric push rod 57 is connected to the turntable 51; a suspension ring 58, fixedly placed on the sealing disc 53, and rotatably connected to the support ring 21; and a strip block 59, which is vertically placed on the shaft 52, and the strip block 59 cooperates with the keyway opened on the center hole of the turntable 51.

[0049] In a preferred embodiment of this solution, the bottom circular plate 55 can be installed at the corresponding position of the dialysate via a support frame fixed to its lower surface. When the turntable 51 needs to move up and down within the detection cylinder 4, the output rod of the first electric push rod 57 extends or retracts, causing the turntable 51 to rise or fall along the length of the shaft 52. When the turntable 51 and the sealing disc 53 need to rotate synchronously, the motor fixed to the upper surface of the bottom circular plate 55 via a vertical support rod operates, causing its output shaft to drive the shaft 52 to rotate. Since the turntable 51 is connected via... The strip block 59 and the keyway are slidably fitted onto the shaft 52. Therefore, the rotation of the shaft 52 will synchronously drive the turntable 51 and the sealing disc 53 to rotate inside the detection cylinder 4, which facilitates the adjustment of the position of the sampler 6 inside the detection cylinder 4 after installation. When the detection cylinder 4 is opened and the sampler 6 needs to be removed from the turntable 51, the turntable 51 needs to be driven to rotate inside the detection cylinder 4 to adjust the sampler 6 to the removal position, which facilitates the removal of the sampler 6, the guide tube 73 and the detection box 8 after testing from the turntable 51.

[0050] See Figures 3 to 5 As shown, the sampler 6 includes: a support slot 511, which is formed through the turntable 51, with the slot opening facing the outer ring surface of the turntable 51, and the support slot 511 is located directly below the syringe 54; a sampling cylinder 61, which is movably inserted into the support slot 511, and a limiting support ring 62 that cooperates with the support slot 511 is fixed on the cylinder wall of the sampling cylinder 61; and a tubular needle 63, which is placed on the top of the sampling cylinder 61, and the needle tip of the tubular needle 63 is aligned with the syringe 54. A piston 64 is movably placed inside the sampling cylinder 61, and a limiting block 66 is provided at the bottom of the piston rod of the piston 64; a second electric push rod 65 is vertically fixed on the bottom surface of the turntable 51, and the output rod end of the second electric push rod 65 faces downward, so as to facilitate docking with the limiting block 66 of the piston 64; and a docking block 67 is placed at the output rod end of the second electric push rod 65, and a T-shaped groove that cooperates with the limiting block 66 is provided on the docking block 67.

[0051] In a preferred embodiment of this solution, when the sampler 6 needs to be installed on the turntable 51, first align the two limiting rings 62 on the sampling cylinder 61 with the upper and lower openings of the support groove 511, and align the syringe 54 with the side opening of the support groove 511. Then push the sampling cylinder 61 so that it is engaged with the rubber layer provided in the support groove 511. The two limiting rings 62 will then be located at the upper and lower openings of the support groove 511, thus achieving proper positioning of the sampling cylinder. 61 provides vertical limiting to prevent the sampling cylinder 61 from moving downward in the support slot 511 when the turntable 51 drives the sampling cylinder 61 and the tubular needle 63 into the rubber stopper 3 due to the resistance of the rubber stopper 3. When the sampling cylinder 61 is inserted into the support slot 511, the limiting block 66 will simultaneously engage with the T-shaped slot on the docking block 67, thereby enabling the piston 64 to be detachably connected to the output rod of the second electric push rod 65.

[0052] When the turntable 51 rises inside the detection cylinder 4, it drives the tubular needle 63 to pierce into the appropriate position of the rubber stopper 3, so that the tubular needle 63 is connected to the waste discharge pipeline. At this time, the output rod of the second electric push rod 65 extends out and, through the cooperation of the limit block 66 and the docking block 67, drives the piston 64 to slide down in the sampling cylinder 61, so that it draws the dialysate flowing in the waste discharge pipeline into the sampling cylinder 61 through the tubular needle 63.

[0053] After a certain amount of dialysate is drawn into the sampling cylinder 61, the turntable 51 needs to be controlled to descend vertically in the detection cylinder 4 so that the tubular needle 63 slowly exits from the rubber stopper 3. When the tip of the tubular needle 63 is completely detached from the rubber stopper 3 and enters the syringe 54, the turntable 51 and the sealing plate 53 can be controlled to rotate so that the syringe 54 and the tubular needle 63 are misaligned with the needle hole that was just pierced on the rubber stopper 3. Then, the turntable 51 continues to descend, which will cause the tubular needle 63 to slowly enter the diversion chamber 71 formed in the diversion plug 7. Then, the output rod of the second electric push rod 65 is controlled to retract, so that it drives the piston rod to rise in the sampling cylinder 61, which facilitates the delivery of the dialysate drawn from the sampling cylinder 61 to the detection box 8 through the guide tube 73 and the branch tube, and then it comes into contact with the test strip for detection.

[0054] When it is necessary to remove and replace the sampler 6 from the turntable 51 after use, first open the detection cylinder 4 and drive the turntable 51 to rotate inside the detection cylinder 4, so that it drives the sampler 6 to rotate to a position that is easy to remove. Then, pull the sampling cylinder 61 radially to make it disengage from the support slot 511, and the limiting block 66 will disengage from the T-shaped slot at the same time, so as to facilitate the removal, replacement or sterilization of the sampler 6.

[0055] See Figures 6 to 8As shown, a sealing plug 72 of the same material as the rubber plug 3 is installed on the top of the diverting plug 7. A diverting cavity 71 is formed inside the diverting plug 7, and the diverting cavity 71 is connected to the guide tube 73. The sealing plug 72 is squeezed and inserted into the bottom opening of the syringe 54.

[0056] A first spring 68 is provided on the upper surface of the limiting support ring 62 located at the groove opening of the support slot 511. The first spring 68 is sleeved on the sampling cylinder 61, and the top of the first spring 68 is detachably connected to the diverter plug 7.

[0057] As a preferred embodiment of this scheme, in order to ensure that the dialysis fluid aspirated in the sampling cylinder 61 can be accurately delivered to the detection box 8 through the split plug 7 and the guide tube 73 in the detection cylinder 4 for the detection of urea nitrogen and creatinine content.

[0058] This design incorporates a diverter plug 7 and a sealing plug 72 that can be sealed onto the tip of the tubular needle 63. When the sampling cylinder 61 is inserted into the support slot 511, the diverter plug 7 and the top sealing plug 72 will be simultaneously positioned at the lower opening of the syringe 54. At this point, the turntable 51 needs to rise within the detection cylinder 4 to push the sealing plug 72 into the syringe 54, while the diverter plug 7 will press against the bottom opening of the syringe 54. When the sampling cylinder 61 pushes the tubular needle 63 into the rubber stopper 3, the needle tube of the tubular needle 63 will simultaneously pass through the sealing plug 72 and enter the rubber stopper 3. At this point, the first spring member 68 will be continuously compressed and stored, and the elastic thrust of the first spring member 68 will act on the limiting support ring 62, thereby increasing the stability and firmness of the sampling cylinder 61 in the support slot 511.

[0059] When the tubular needle 63 disengages from the rubber stopper 3 (the turntable 51 moves away from the sealing disc 53), the release of the elastic potential energy of the first spring 68 will generate an upward pushing force on the diverter 7, which can effectively prevent the tubular needle 63 from moving downward in the sealing stopper 72. Due to the friction between the tubular needle 63 and the sealing stopper 72, the sealing stopper 72 will disengage from the syringe 54, which will affect the diverter cavity 71 formed in the diverter 7 from accurately delivering the extracted dialysate to the guide tube 73.

[0060] When the tubular needle 63 retracts into the shunt chamber 71, the recovery of the sealing plug 72's own toughness will seal the formed needle hole, allowing the sealing plug 72 at the top of the shunt plug 7 to seal the shunt chamber 71. This allows the dialysate drawn from the sampling cylinder 61 to be input into the shunt chamber 71 through the tubular needle 63, and then transported to the guide tube 73 through the shunt chamber 71. This eliminates the need for the operator to remove the sampling cylinder 61 containing the dialysate from the detection cylinder 4, enabling rapid and accurate detection of urea nitrogen and creatinine content in the extracted dialysate.

[0061] When the sampler 6 needs to be removed from the turntable 51, the turntable 51 needs to be controlled to continue descending inside the detection cylinder 4, so that the sealing plug 72 is disengaged from the bottom opening of the syringe 54 by the first spring 68. Then the sampling cylinder 61 is removed from the support slot 511. At this time, the limiting block 66 will be disengaged from the docking block 67, which makes it easier to remove and replace the sampler 6, the diverter plug 7 and the corresponding components from the detection cylinder 4.

[0062] See Figures 6 to 8 As shown, a bent piece 691 is provided on the top spiral ring of the first spring member 68, and the vertical piece of the bent piece 691 is movably inserted into the insertion groove opened on the diverter plug 7. A pin hole is formed on the side wall of the insertion groove, which is aligned with the through hole formed on the bent piece 691, and a pin is inserted into the pin hole.

[0063] A limiting rod 69 is vertically provided on the horizontal piece of the bent piece 691, and the bottom end of the limiting rod 69 moves downward through two limiting support rings 62 to connect to the limiting block.

[0064] As a preferred embodiment of this solution, in order to facilitate the disassembly of the top of the first spring member 68 from the diversion plug 7 and to facilitate the separation of the diversion plug 7 and the guide tube 73 of the disposable medical supplies from the sampler 6, this solution provides at least two bent pieces 691 on the first spring member 68, so that the vertical pieces of the bent pieces 691 are inserted into the insertion groove opened upward at the bottom of the diversion plug 7, and then the bent pieces 691 and the diversion plug 7 can be accurately connected through the cooperation of the pin, pin hole and through hole inserted into the outer ring surface of the diversion plug 7;

[0065] When the sampler 6 is removed from the detection cylinder 4, the operator can pull out the pins on the outer ring of the diverter 7 in sequence, and then pull the diverter 7 so that the diverter 7 can not only separate from the first spring 68, but also separate the needle tip of the tubular needle 63 from the diverter cavity 71.

[0066] Since the limiting rod 69 is located inside the first spring member 68, when the tubular needle 63 moves towards the rubber stopper 3 and is inserted, and the first spring member 68 is compressed, the limiting rod 69 will slide relative to the limiting support ring 62 (the limiting block will move away from the limiting support ring 62). When the tubular needle 63 is continuously pushed out from the rubber stopper 3, the limiting support ring 62 will slide towards the limiting block. When the tip of the tubular needle 63 is in the diversion cavity 71, the limiting block will abut against the bottom surface of the lower limiting support ring 62 (which can be used as the limit position for the tip of the tubular needle 63 to move into the diversion cavity 71, preventing the tip from detaching from the diversion cavity 71).

[0067] When the shunt plug 7 needs to be detached from the syringe 54, the turntable 51 continues to descend within the detection cylinder 4. Through the contact action of the limiting block and the limiting support ring 62, the limiting rod 69 can drive the shunt plug 7 to quickly remove the inserted sealing plug 72 from the syringe 54. This prevents the first spring 68 from being stretched first when only the first spring 68 is connected to the shunt plug 7. (At this time, the needle tip of the tubular needle 63 will detach from the shunt cavity 71, causing the residual dialysate in the shunt cavity 71 to drip into the detection cylinder 4.) This would then pull the shunt plug 7 out of the lower opening of the syringe 54, which would affect the safe separation effect of the shunt plug 7 from the syringe 54.

[0068] See Figure 1 and Figure 2 As shown, the detection cylinder 4 is movably sleeved on the bottom circular plate 55, and the inner wall of the detection cylinder 4 is provided with a vertical guide bar that cooperates with the guide notch opened on the bottom circular plate 55. The upper cylinder opening of the detection cylinder 4 is connected to the connecting pipe 2 through the fastening assembly 9.

[0069] The fastening assembly 9 includes: a support base 91, with several circumferentially arranged on the outer ring surface of the upper opening of the detection cylinder 4; a fastening rod 92, which is movably inserted into the support base 91, and the bottom of the fastening rod 92 is connected to the support base 91 by a second spring; a locking block 93, with several circumferentially arranged on the outer wall of the connecting pipe 2, and a locking notch is provided on the locking block 93; a rotating head 94, which is rotatably mounted on the top of the fastening rod 92 via a rotating rod; and a fastening block 95, which is fixed on the rotating head 94.

[0070] When the fastening rod 92 passes upward through the engaging notch, the fastening block 95 rotates and fits against the upper surface of the engaging block 93;

[0071] As a preferred embodiment of this solution, part of the cylinder of the detection cylinder 4 can be made of transparent material to facilitate observation of the condition of each component inside the detection cylinder 4. When the detection cylinder 4 needs to slide vertically downward along the bottom circular plate 55 to open, the latching block 95 is moved so that it rotates around the latching rod 92 via the rotating head 94, so that the latching block 95 rotates to align with the locking notch. Then, the second spring member stretched inside the support base 91 will pull the latching rod 92 back into the support base 91. At this time, the latching rod 92 will drive the rotating head 94 to disengage from the latching block 93, which makes it easier for the operator to push the detection cylinder 4 downward and slide the detection cylinder 4 downward to open, making it easier for the operator to replace components such as the sampler 6.

[0072] After the new sampler 6 and other components are installed on the turntable 51, pull the detection cylinder 4 upwards so that the locking rod 92 is below the locking block 93. Then, push the locking block 95 upwards so that the locking rod 92 is pulled out from the support base 91. The second spring will be stretched. When the locking block 95 rises above the locking notch, rotate the locking block 95 to disengage it from the locking notch. This allows the locking block 95 to be supported on the locking block 93, enabling the detection cylinder 4 to be detachably connected to the connecting pipe 2.

[0073] In the description of this specification, references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0074] The preferred embodiments of the present invention disclosed above are merely illustrative of the invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the invention to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of the invention, thereby enabling those skilled in the art to better understand and utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims

1. A device for detecting urea nitrogen and creatinine contents in a blood dialysis solution, comprising a shunt connected to a liquid line of a dialyzer, characterized in that, Also include: The communication pipe is detachably installed on the shunt pipe, the pipe bottom of the communication pipe is formed with a support ring, and the support ring is attached to the pipe bottom of the shunt pipe, a rubber plug is installed on the support ring; The bottom of the communication pipe is connected with a detection cylinder, and a sampling sealing mechanism is arranged in the detection cylinder; The sampling sealing mechanism comprises a rotating disc movably arranged in the detection cylinder, a sealing disc connected with the rotating disc through a shaft rod, and a needle cylinder installed on the sealing disc; The sealing disc is rotatably attached to the bottom surface of the rubber plug, and a sampler is detachably installed on the rotating disc; The sampler is detachably connected with a shunt plug, and the shunt plug is communicated with a plurality of detection boxes through a flow guide pipe, a plurality of detection boxes are placed on the rotating disc, and a detection test paper is placed in each detection box; The sampler comprises: A support clamping groove is provided through the rotating disc, the groove opening of the support clamping groove faces the outer ring surface of the rotating disc and is located directly below the needle cylinder; A sampling cylinder is movably clamped into the support clamping groove, and a limiting support ring is fixedly arranged on the cylinder wall of the sampling cylinder and matched with the support clamping groove; A tubular needle is arranged on the top of the sampling cylinder, and the needle head of the tubular needle is aligned with the needle cylinder; A piston is movably arranged in the sampling cylinder, and a limiting block is arranged at the bottom of the piston rod of the piston; A second electric push rod is vertically fixedly arranged on the bottom surface of the rotating disc, and the output rod end of the second electric push rod is in a downward state; And a butt joint block is arranged on the output rod end of the second electric push rod, and a T-shaped clamping groove matched with the limiting block is arranged on the butt joint block; The top of the shunt plug is provided with a sealing plug made of the same material as the rubber plug, the shunt plug is internally formed with a shunt cavity, and the shunt cavity is communicated with the flow guide pipe, and the sealing plug is inserted into the bottom cylinder opening of the needle cylinder; The top surface of the limiting support ring located on the groove opening of the support clamping groove is provided with a first spring, the first spring is sleeved on the sampling cylinder, and the top of the first spring is detachably connected with the shunt plug.

2. The device for detecting the contents of urea nitrogen and creatinine in hemodialysis fluid according to claim 1, characterized in that, The sampling sealing mechanism further comprises: A bottom circular plate is arranged at the bottom of the detection cylinder, and a motor for driving the shaft rod to rotate is fixedly arranged in the middle of the bottom circular plate; A support rotating ring is rotatably arranged on the bottom circular plate; A first electric push rod is fixedly arranged on the support rotating ring, and the output rod of the first electric push rod is connected with the rotating disc; A suspension ring is fixedly arranged on the sealing disc, and the suspension ring is rotatably connected with the support ring; And a strip block is vertically arranged on the shaft rod, and the strip block is matched with the key groove arranged on the center hole of the rotating disc.

3. The device for detecting the contents of urea nitrogen and creatinine in hemodialysis fluid according to claim 1, characterized in that, The top spiral of the first spring is provided with a bent piece, the vertical piece of the bent piece is movably inserted into the insertion slot arranged on the shunt plug, the side groove wall of the insertion slot is formed with a pin hole matched with the through hole formed on the bent piece, and a pin is inserted into the pin hole; The vertical limiting rod is arranged on the horizontal piece of the bent piece, and the bottom end of the vertical limiting rod is movably inserted into the limiting block through the two limiting support rings.

4. The device for detecting the contents of urea nitrogen and creatinine in hemodialysis fluid according to claim 2, characterized in that, The detection cylinder is movably sleeved on the bottom circular plate, and the inner cylinder wall of the detection cylinder is provided with a vertical guide strip matched with the guide notch arranged on the bottom circular plate, and the upper cylinder opening of the detection cylinder is connected with the communication pipe through a buckling assembly.

5. The urea nitrogen and creatinine content detection device for hemodialysis fluid according to claim 4, characterized in that, The buckling assembly comprises: The support seat is arranged on the outer ring surface of the upper barrel mouth of the detection barrel in a plurality of circumferences; The buckle rod is movably inserted into the support seat, and the rod bottom of the buckle rod is connected with the support seat through the second spring piece; The buckle block is arranged on the outer pipe wall of the communication pipe in a plurality of circumferences, and the buckle block is provided with a clamping gap; The rotating head is rotatably installed on the top of the buckle rod through the rotating rod; And the buckle block is fixedly arranged on the rotating head; When the buckle rod passes through the clamping gap upwards, the buckle block is rotatably attached to the upper surface of the buckle block.

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