Sodium hyaluronate-coated hinokiol microsphere stable anti-dandruff composition and preparation method thereof

Abstract

The invention discloses a sodium hyaluronate-coated hinokiol microbead stable anti-dandruff composition and a preparation method thereof, and the sodium hyaluronate-coated hinokiol microbead stable anti-dandruff composition comprises the following components by mass: 2%-6% of sodium hyaluronate-coated hinokiol microbeads, 10%-20% of a surfactant, 0.1%-5% of a humectant, 0.01%-3% of a thickener, 0.01%-3% of a pH regulator, 0.001%-0.5% of a preservative, and the balance of water. The sum of the mass fractions of the components does not exceed 100%, and the balance is filler. According to the method, hinokiol is prevented from being influenced by illumination and free radicals, meanwhile, hinokiol is effectively isolated from formula materials, it is guaranteed that hinokiol stably exists in the transparent packaging material for a long time, and the antibacterial rate is increased.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of cosmetics, in particular to a stable anti-dandruff composition of sodium hyaluronate coated hinokitiol microbeads and a preparation method thereof. BACKGROUND

[0002] In the field of scalp care, anti-dandruff is always the core demand of consumers, and the overgrowth of Malassezia is the key factor causing dandruff. As an anti-dandruff active ingredient, hinokitiol has excellent inhibitory effect on Malassezia colonization and has important application value in anti-dandruff products.

[0003] However, hinokitiol itself has obvious stability defects: it is easily affected by light and free radicals in the formula to cause oxidative decomposition, resulting in loss of activity. In actual shampoo formulations, this instability is particularly pronounced. UV radiation during transparent packaging, free radicals generated by oxidation of raw materials, impurities in raw materials, and other factors in the formula system continuously damage the chemical structure of hinokitiol, greatly reducing its antifungal properties, and thus affecting the anti-dandruff effect and shelf life of the product.

[0004] In the prior art, although there are encapsulation technologies for active ingredients, most of them cannot solve the problem of the dual influence of light and free radicals, and it is difficult to achieve effective isolation of hinokitiol from the shampoo formula material body, which cannot meet the requirement of long-term stability in transparent packaging materials. If the stability problem of hinokitiol cannot be properly solved, its excellent antifungal efficacy cannot be fully utilized, which limits its wide application in anti-dandruff products. SUMMARY

[0005] In view of the problems of the existing sodium hyaluronate coated hinokitiol microbead stable anti-dandruff composition, the present application provides a sodium hyaluronate coated hinokitiol microbead stable anti-dandruff composition and a preparation method thereof. The sodium hyaluronate coated hinokitiol microbead stable anti-dandruff composition protects hinokitiol from the influence of light and free radicals, and simultaneously achieves effective isolation from the formula material body, ensuring long-term stability in transparent packaging materials.

[0006] A sodium hyaluronate coated hinokitiol microbead stable anti-dandruff composition, comprising the following components by mass fraction: sodium hyaluronate coated hinokitiol microbeads 2%-6%, surfactant 10%-20%, humectant 0.1%-5%, thickening agent 0.01%-3%, pH adjuster 0.01%-3%, preservative 0.001%-0.5%, the mass fraction of the above components adding up to no more than 100%, and the balance being fillers.

[0007] The stable anti-dandruff composition with sodium hyaluronate coated hinokitiol microbeads provided by the present application can effectively resist the damage of light and free radicals in the formula to hinokitiol, isolate hinokitiol from the body of the shampoo formula, ensure the long-term stability of hinokitiol in the transparent package material, and prolong the effective shelf life and the persistence of the anti-dandruff effect of the product.

[0008] In addition, the stable anti-dandruff composition with sodium hyaluronate coated hinokitiol microbeads provided by the present application can also have the following additional technical features: Preferably, the stable anti-dandruff composition with sodium hyaluronate coated hinokitiol microbeads comprises the following components by mass fraction: sodium hyaluronate coated hinokitiol microbeads 4%, surfactant 14%, humectant 4%, thickening agent 1%, pH adjuster 0.2%, preservative 0.3%, and the mass fraction of the above components does not exceed 100%, and the balance is filler.

[0009] Preferably, the surfactant comprises sodium laureth sulfate, cocamidopropyl betaine, and sodium lauryl sulfate.

[0010] Preferably, the humectant is a combination of one or more of glycerin, propylene glycol, and butylene glycol.

[0011] Preferably, the thickening agent is a combination of one or more of acrylic acid copolymer, propenyl acetate / C10-30 alkanol propenyl acetate cross-linked polymer, and acrylic acid / beheneth-25 methacrylate copolymer.

[0012] Preferably, the pH adjuster is a combination of one or more of citric acid, lactic acid, and sodium phytate.

[0013] Preferably, the preservative is a combination of one or more of phenoxyethanol, sodium benzoate, and methyl isothiazolinone.

[0014] Preferably, the filler is deionized water.

[0015] The present application also provides a preparation method of the stable anti-dandruff composition with sodium hyaluronate coated hinokitiol microbeads, comprising the following steps: (1) mixing hinokitiol, base oil, and antioxidant to obtain a coated phase, and mixing sodium hyaluronate, ultraviolet absorbing component, particle solidifying component, and deionized water to obtain a coating phase; (2) injecting the wrapped phase and the wrapping phase into different microchannels of a microfluidic device respectively, taking the wrapping phase as a continuous phase and the wrapped phase as a dispersed phase in the different microchannels, adjusting the flow rates of the two phases to emulsify the wrapped phase in the wrapping phase to form emulsion droplets, introducing the formed emulsion droplets into a solidification channel, and controlling the temperature and time to gradually solidify sodium hyaluronate in the wrapping phase to form the sodium hyaluronate-wrapped cyprenol microbeads; (3) adding the filler into a reaction kettle, heating to 70-80°C, adding the thickening agent, stirring until completely dissolved, and keeping warm for 10-15 minutes to obtain an aqueous phase; (4) cooling to 50-60°C, adding the surfactant into the aqueous phase, and stirring until uniform at a stirring rate of 300-400 r / min for 10-15 minutes; (5) continuing to cool to 40-45°C, adding the humectant and the preservative, and stirring until uniform at a stirring rate of 200-300 r / min for 5-10 minutes; (6) cooling to 30-35°C, adding the sodium hyaluronate-wrapped cyprenol microbeads, and stirring until mixed uniformly at a stirring rate of 100-150 r / min for 5-10 minutes; (7) adjusting the pH value of the system to 5.5-6.5 by using a pH regulator to obtain the sodium hyaluronate-wrapped cyprenol microbead stable anti-dandruff composition.

[0016] In addition, the preparation method of the sodium hyaluronate-wrapped cyprenol microbead stable anti-dandruff composition can also have the following additional technical features: Preferably, the base oil is at least one of caprylic acid / capric acid triglyceride and tea seed oil, the antioxidant is rosemary extract, the ultraviolet absorbing component is at least one of benzophenone-4, pomegranate peel extract, ginger root extract, titanium dioxide, and zinc dioxide, and the particle solidification component is at least one of sodium alginate, carrageenan, xanthan gum, and agar.

[0017] The present application has at least the following advantages: (1) The cyprenol is wrapped by the sodium hyaluronate microbeads, the antioxidant component (rosemary extract) and the ultraviolet absorbing component contained in the wrapping phase can effectively resist the damage of light and free radicals in the formula to the cyprenol, and the cyprenol is isolated from the shampoo formula material body to ensure its long-term stability in the transparent packaging material; (2) The stable cyprenol can continuously inhibit the Malassezia, avoids the decline of the anti-dandruff effect caused by the oxidation and decomposition of the cyprenol, and prolongs the effective shelf life and the durability of the anti-dandruff effect of the product; (3) The composition uses an amphoteric surfactant (cocamidopropyl betaine) for compounding, enhances the micellar structure of the system, is low in irritation, is suitable for use on various scalp types, and meanwhile, the sodium hyaluronate has a moisturizing effect and can improve the scalp environment; (4) The microbeads are prepared by using a microfluidic method, the size (diameter 0.5-5mm) and morphology of the microbeads can be accurately controlled, the uniformity and stability of the microbeads are ensured, and the industrialized production is facilitated.

[0018] Additional aspects and advantages of the present application will be partially given in the following description, partially will become obvious from the following description, or will be understood by the practice of the present application. DETAILED DESCRIPTION

[0019] In order to make the purpose, features and advantages of the present application more obvious and easy to understand, the specific embodiments of the present application will be described in detail below. Several embodiments of the present application are given in the examples. However, the present application can be realized in many different forms, and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present application more thorough and comprehensive.

[0020] Example 1 A sodium hyaluronate-coated cypressol microbead stable anti-dandruff composition comprises the following components by mass fraction: sodium hyaluronate-coated cypressol microbeads 4%, surfactant 14%, humectant 4%, thickening agent 1%, pH adjuster 0.2%, preservative 0.3%, the mass fraction of the above components does not exceed 100%, and the balance is filler.

[0021] The surfactant includes sodium laureth sulfate, cocamidopropyl betaine, and sodium lauryl sulfate. Specifically, the surfactant includes sodium laureth sulfate 7%, cocamidopropyl betaine 3%, and sodium lauryl sulfate 4%.

[0022] The humectant is a combination of one or more of glycerin, propylene glycol, and butylene glycol. Specifically, the humectant is glycerin 4%.

[0023] The thickening agent is a combination of one or more of an acrylic acid copolymer, a propenyl ester / C10-30 alkanol propenyl ester cross-linked polymer, and an acrylic acid / beheneth-25 methacrylate copolymer. Specifically, the thickening agent is a propenyl ester / C10-30 alkanol propenyl ester cross-linked polymer 1%.

[0024] The pH adjuster is a combination of one or more of citric acid, lactic acid, and sodium phytate. Specifically, the pH regulator is citric acid 0.2%.

[0025] The preservative is a combination of any one or more of phenoxyethanol, sodium benzoate, and methylisothiazolinone. Specifically, the preservative is phenoxyethanol 0.3%.

[0026] The filler is deionized water.

[0027] For the above-mentioned stable anti-dandruff composition of sodium hyaluronate-coated hinokitiol microbeads, by coating hinokitiol with sodium hyaluronate microbeads, the antioxidant ingredients (rosemary extract) and ultraviolet-absorbing ingredients contained in the coating phase can effectively resist the damage of light and free radicals in the formula to hinokitiol, isolate hinokitiol from the shampoo formula material body, and ensure its long-term stability in the transparent packaging material. Stable hinokitiol can continuously inhibit the growth of Malassezia, avoid the decline of anti-dandruff effect caused by the oxidation and decomposition of hinokitiol, and prolong the effective shelf life and the persistence of anti-dandruff effect. The use of amphoteric surfactant (cocamidopropyl betaine) in the composition enhances the micellar structure of the system, has low irritation, and is suitable for use on various types of scalp. At the same time, sodium hyaluronate has a moisturizing effect and can improve the scalp environment.

[0028] The preparation method of the above-mentioned stable anti-dandruff composition of sodium hyaluronate-coated hinokitiol microbeads comprises the following steps: (1) mixing hinokitiol, base oil, and antioxidant to obtain a coated phase, and mixing sodium hyaluronate, ultraviolet-absorbing ingredients, particle solidifying ingredients, and deionized water to obtain a coating phase; Wherein, the coated phase is obtained by mixing 0.5%-20% of hinokitiol, 70%-85% of base oil, and 3%-5% of antioxidant, the base oil is at least one of caprylic acid / capric acid triglyceride and tea seed oil, and the antioxidant is rosemary extract; In this embodiment, the content of hinokitiol is 5%, the content of base oil is 81%, and the content of antioxidant is 14%; Wherein, the coating phase is obtained by mixing 0.1%-10% of sodium hyaluronate, 0.1%-5% of ultraviolet-absorbing ingredients, 1-10% of particle solidifying ingredients, and deionized water, and the balance is deionized water, the ultraviolet-absorbing ingredients are at least one of benzophenone-4, pomegranate peel extract, ginger root extract, titanium dioxide, and zinc dioxide, and the particle solidifying ingredients are at least one of sodium alginate, carrageenan, xanthan gum, and agar; In this embodiment, the content of sodium hyaluronate is 5%, the content of ultraviolet-absorbing ingredients is 3%, and the content of particle solidifying ingredients is 5%, and the balance is deionized water.

[0029] Meanwhile, for the rosemary extract, the extraction method is as follows: a certain amount of rosemary leaves is extracted by acid ethanol, and the extraction liquid is prepared after filtration; the pH of the acid ethanol is 2.8-3.5; the acid used in the acid ethanol is hydrochloric acid, phosphoric acid, sulfuric acid or other inorganic acid; decolorization: 0.1%-1.5% of a decolorizing agent is added to the extraction liquid, and the decolorized liquid is prepared after filtration; pH adjustment: the decolorized liquid is adjusted to 4.0-4.5 by adding a target pH adjuster; the target pH adjuster is ammonia water; resin purification: the decolorized liquid after pH adjustment is concentrated, deodorized and filtered, the filtrate is columned on a macroporous adsorption resin and completely adsorbed, then pure water is used for elution, and then 60-80% of an ethanol solution is used for resolution to obtain a resolution liquid, the resolution liquid is adjusted to pH 4.0-5.5, concentrated, deodorized, dried, and the rosemary extract is obtained; For the pomegranate peel extract, the extraction process is as follows: the pomegranate peel is dried or ground into powder, then soaked and stirred in ethanol for a period of time, and finally the pomegranate peel extract is obtained through process steps such as filtration and concentration; For the ginger root extract, the extraction process is as follows: the ginger root is crushed, a suitable solvent (such as ethanol, water, etc.) is selected, the effective components in the ginger root are dissolved in the solvent, then the solvent is removed through filtration and evaporation, and the ginger root extract is obtained.

[0030] (2) The wrapped phase and the wrapping phase are injected into different microchannels of a microfluidic device respectively, and in different microchannels, the wrapping phase is taken as a continuous phase and the wrapped phase is taken as a dispersed phase, the flow rates of the two phases are adjusted, the wrapped phase is emulsified in the wrapping phase to form emulsion droplets, the formed emulsion droplets are introduced into a solidification channel, the temperature and time are controlled, the sodium hyaluronate in the wrapping phase is gradually solidified, and sodium hyaluronate wrapped hinokitiol microbeads are formed; Specifically, the temperature controlled here is 30-40℃, the time controlled here is 5-10 minutes, and the diameter of the sodium hyaluronate wrapped hinokitiol microbeads obtained here is 0.5-5mm.

[0031] (3) The filler is added to a reaction kettle, the temperature is raised to 70-80℃, the thickening agent is added, and stirring is performed until complete dissolution, and the water phase is obtained after 10-15 minutes of heat preservation; (4) The temperature is lowered to 50-60℃, the surfactant is added to the water phase, and stirring is performed until uniform, the stirring rate is 300-400r / min, and the stirring time is 10-15 minutes; (5) The temperature is continuously lowered to 40-45℃, the humectant and the preservative are added and stirred uniformly, the stirring rate is 200-300r / min, and the stirring time is 5-10 minutes; (6) cooling to 30-35℃, adding sodium hyaluronate to wrap the microbeads of cyprenol, stirring until mixed evenly, stirring rate is 100-150r / min, stirring time is 5-10 minutes; (7) adjusting the pH value of the system to 5.5-6.5 with pH regulator to obtain the stable anti-dandruff composition of sodium hyaluronate wrapped cyprenol microbeads.

[0032] Example 2 The present example provides a stable anti-dandruff composition of sodium hyaluronate wrapped cyprenol microbeads, the components of which are substantially the same as those in Example 1, the difference between the present example and Example 1 is that the mass fraction of sodium hyaluronate wrapped cyprenol microbeads in the present example is 2%.

[0033] Example 3 The present example provides a stable anti-dandruff composition of sodium hyaluronate wrapped cyprenol microbeads, the components of which are substantially the same as those in Example 1, the difference between the present example and Example 1 is that the mass fraction of sodium hyaluronate wrapped cyprenol microbeads in the present example is 6%.

[0034] Example 4 The present example provides a stable anti-dandruff composition of sodium hyaluronate wrapped cyprenol microbeads, the components of which are substantially the same as those in Example 1, the difference between the present example and Example 1 is that the mass fraction of surfactant in the present example is 10%.

[0035] Example 5 The present example provides a stable anti-dandruff composition of sodium hyaluronate wrapped cyprenol microbeads, the components of which are substantially the same as those in Example 1, the difference between the present example and Example 1 is that the mass fraction of surfactant in the present example is 20%.

[0036] Example 6 The present example provides a stable anti-dandruff composition of sodium hyaluronate wrapped cyprenol microbeads, the components of which are substantially the same as those in Example 1, the difference between the present example and Example 1 is that the mass fraction of cyprenol in the wrapped phase for preparing sodium hyaluronate wrapped cyprenol microbeads in the present example is 0.5%.

[0037] Example 7 The present example provides a stable anti-dandruff composition of sodium hyaluronate wrapped cyprenol microbeads, the components of which are substantially the same as those in Example 1, the difference between the present example and Example 1 is that the mass fraction of cyprenol in the wrapped phase for preparing sodium hyaluronate wrapped cyprenol microbeads in the present example is 20%.

[0038] Example 8 The present example provides a stable anti-dandruff composition of sodium hyaluronate coated hinokitiol microbeads, which has substantially the same components as those in Example 1. The difference between the present example and Example 1 is that the mass fraction of sodium hyaluronate in the coating phase for preparing the sodium hyaluronate coated hinokitiol microbeads in the present example is 0.1%.

[0039] Example 9 The present example provides a stable anti-dandruff composition of sodium hyaluronate coated hinokitiol microbeads, which has substantially the same components as those in Example 1. The difference between the present example and Example 1 is that the mass fraction of sodium hyaluronate in the coating phase for preparing the sodium hyaluronate coated hinokitiol microbeads in the present example is 10%.

[0040] Comparative Example 1 The present comparative example is substantially the same as Example 1, except that no surfactant is added in the present comparative example.

[0041] Comparative Example 2 The present comparative example is substantially the same as Example 1, except that no sodium hyaluronate coated hinokitiol microbeads are added in the present comparative example.

[0042] Comparative Example 3 The present comparative example is substantially the same as Example 1, except that the hinokitiol is coated with a cyclodextrin in the prior art.

[0043] Comparative Example 4 The present comparative example is substantially the same as Example 1, except that the hinokitiol is coated with a liposome in the prior art.

[0044] Comparative Example 5 The present comparative example is substantially the same as Example 1, except that the hinokitiol is directly added without being coated with sodium hyaluronate.

[0045] The stable anti-dandruff compositions of sodium hyaluronate coated hinokitiol microbeads obtained in the above examples and comparative examples are prepared into dandruff-removing stock solutions, and the corresponding culture medium is selected to culture Malassezia. The test instruments used are an anaerobic incubator, a biological safety cabinet, and a low-temperature constant-temperature tank. It should be noted that each of the above comparative examples and examples is provided with three groups of experimental samples. The dandruff-removing stock solution in the corresponding comparative example or example is added to the corresponding Malassezia, and after 7 days of culture, the number of residual Malassezia is determined to determine the corresponding antibacterial rate. The antibacterial rates of the three groups of samples are averaged to obtain the final antibacterial rate. The final antibacterial rate results of the above examples and comparative examples are shown in Table 1. Table 1

[0046] Referring to Table 1, the antibacterial rates of Comparative Examples 2, 3, 4 and 5 are obviously lower than that of Example 1 when the mass fraction of the surfactant is too high or too low, and the decrease degree of Examples 2 and 3 is higher than that of Examples 4 and 5, because the hyaluronic acid sodium wrapped cypressin microbeads are the main antibacterial component and play a main antibacterial effect, while the surfactant plays an auxiliary role and has a moisturizing effect, can improve the scalp environment and enhance the antibacterial effect, and there is a synergistic effect between the two. When the mass fraction of cypressin in the wrapped phase of the hyaluronic acid sodium wrapped cypressin microbeads is too high or too low in Comparative Examples 6 and 7, the content of the corresponding effective component is also too high or too low, which will affect the antibacterial rate, and the antibacterial rate is also lower than that of Example 1, but the decrease degree is higher than that of the previous Examples 2 and 3, because it will affect the stability and durability of the finally obtained hyaluronic acid sodium wrapped cypressin microbeads, and too low will lead to too strong wrapping ability, affecting the release effect and thus affecting the antibacterial effect, and too high will lead to too weak wrapping ability, affecting the stability and thus affecting the antibacterial effect. When the mass fraction of hyaluronic acid sodium in the wrapped phase of the hyaluronic acid sodium wrapped cypressin microbeads is too high or too low in Comparative Examples 8 and 9, it is similar to Example 6 and 7, which will affect the stability and durability of the hyaluronic acid sodium wrapped cypressin microbeads, and too high mass fraction of hyaluronic acid sodium will lead to too strong wrapping ability, affecting the release effect and thus affecting the antibacterial effect, and too low mass fraction of hyaluronic acid sodium will lead to too weak wrapping ability, affecting the stability and thus affecting the antibacterial effect, and the decrease degree is similar to that of Example 6 and 7 compared with Example 1, both of which affect the wrapping ability and thus affect the antibacterial rate. For Control Group 1, no surfactant is added, but it still has an antibacterial rate of 81%, because the main antibacterial component is still in effect, but the auxiliary effect of the surfactant is lost. The antibacterial rate of Control Example 2 is 0, which needs to be explained that in this application, the antibacterial rate less than 30% is recorded as 0, because there is no hyaluronic acid sodium wrapped cypressin microbeads in Control Example 2, so there is no effective antibacterial component, therefore the antibacterial rate is the lowest. According to Comparative Examples 4 and 5, they use cyclodextrin and liposome to wrap cypressin in the existing technology, and according to the antibacterial rate, the antibacterial rates are 75 and 80 respectively, which are much lower than that of Example 1, because after being wrapped by cyclodextrin, the wrapping effect is not absolutely firm, when there are a large number of highly active free radicals in the formula, free radicals can still attack and penetrate the wrapping layer, leading to oxidation of cypressin. It cannot effectively solve the problem of free radicals at the same time, and the wrapping effect is highly dependent on the process, and the ideal wrapping rate will lead to a large amount of free cypressin exposed outside, in the shampoo system, the surfactant may compete with the cyclodextrin, leading to "leakage" of cypressin during storage, and thus affecting the antibacterial rate. For liposomes, they are very fragile,The high temperature, pH value change, mechanical shear (such as stirring pump in the production process) is very sensitive, easy to break and leak, and then will affect its wrapping effect, at the same time, phospholipid itself is easy to oxidize and rancidity, produce new free radicals, which will accelerate the oxidation and decomposition of hinokitiol, thus affecting its wrapping effect, and then affecting the inhibition rate, according to the comparative example 5, it does not wrap hinokitiol, so it is easy to be affected by light and free radicals in the formula to cause oxidation and decomposition, resulting in loss of activity, due to ultraviolet irradiation and free radicals produced by oxidation of raw materials, impurities in raw materials and other factors in the formula system, which will continuously damage the chemical structure of hinokitiol, and greatly reduce its antifungal performance, so its inhibition rate is only 55%.

[0047] In summary, the above examples and comparative examples, by wrapping hinokitiol with sodium hyaluronate microbeads, the absorption of free radical antioxidant components (rosemary extract) and ultraviolet components in the wrapping phase can effectively resist the damage of light and free radicals in the formula to hinokitiol, isolate hinokitiol from the shampoo formula material body, and ensure its long-term stability in the transparent packaging material; stable hinokitiol can continuously inhibit the growth of malassezia, avoid the decline of dandruff effect caused by oxidation and decomposition of hinokitiol, and prolong the effective shelf life and dandruff effect of the product; the use of amphoteric surfactant (cocamidopropyl betaine) in the composition can enhance the micellar structure of the system, reduce irritation, and be suitable for various types of scalp. At the same time, the use of sodium hyaluronate to wrap hinokitiol microbeads can effectively prevent the destruction of hinokitiol by free radicals and ultraviolet light, thereby improving the antibacterial effect. In addition, the sodium hyaluronate wrapped hinokitiol microbeads and the surfactant can have a synergistic effect, and the wrapped phase and the wrapped phase can also have a synergistic effect, thereby further improving the antibacterial effect. In the description of the present specification, the description of the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" and the like means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In the present specification, the illustrative description of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0048] The above-described embodiments only express several embodiments of the present application, and the description is more specific and detailed, but it cannot be understood as limiting the scope of the present patent. It should be noted that for ordinary skilled persons in the art, without departing from the concept of the present application, a number of modifications and improvements can be made, which are within the scope of the present application. Therefore, the protection scope of the present patent should be subject to the appended claims.

Claims

1. A stable anti-dandruff composition of sodium hyaluronate coated microbeads of cedrol, characterized in that, The mass fraction comprises the following components: 2%-6% of hyaluronic acid sodium wrapped chenopodium oil microbeads, 10%-20% of surfactant, 0.1%-5% of humectant, 0.01%-3% of thickening agent, 0.01%-3% of pH regulator, and 0.001%-0.5% of preservative, the mass fraction of the above components is less than 100%, and the rest is filler.

2. The stabilized anti-dandruff composition of claim 1, wherein, The mass fraction of the hyaluronic acid sodium wrapped chenopodium oil microbead stable anti-dandruff composition comprises the following components: 4% of hyaluronic acid sodium wrapped chenopodium oil microbeads, 14% of surfactant, 4% of humectant, 1% of thickening agent, 0.2% of pH regulator, and 0.3% of preservative, the mass fraction of the above components is less than 100%, and the rest is filler.

3. The stabilized anti-dandruff composition of claim 1, wherein, The surfactant comprises sodium laureth sulfate, cocamidopropyl betaine, and sodium dodecyl sulfate.

4. The stabilized anti-dandruff composition of claim 1, wherein, The humectant is a combination of one or more of glycerol, propylene glycol, and butylene glycol.

5. The stabilized anti-dandruff composition of claim 1, wherein, The thickening agent is a combination of one or more of acrylic acid copolymer, acrylates / C10-30 alkyl acrylate crosspolymer, and acrylates / beheneth-25 methacrylate copolymer.

6. The stabilized anti-dandruff composition of claim 1, wherein, The pH regulator is a combination of one or more of citric acid, lactic acid, and sodium phytate.

7. The stabilized anti-dandruff composition of claim 1, wherein, The preservative is a combination of one or more of phenoxyethanol, sodium benzoate, and methylisothiazolinone.

8. The stabilized anti-dandruff composition of claim 1, wherein, The filler is deionized water.

9. The method for preparing the stable anti-dandruff composition of the toric hyaluronate-encapsulated cedrene microbeads according to any one of claims 1 to 8, characterized in that, The method comprises the following steps: (1) mixing chenopodium oil, base oil, and antioxidant to obtain a wrapped phase, and mixing hyaluronic acid sodium, ultraviolet absorbing component, particle curing component, and deionized water to obtain a wrapping phase; (2) injecting the wrapped phase and the wrapping phase into different microchannels of a microfluidic device respectively, taking the wrapping phase as a continuous phase and the wrapped phase as a dispersed phase in the different microchannels, adjusting the flow rates of the two phases to emulsify the wrapped phase in the wrapping phase to form emulsion droplets, introducing the formed emulsion droplets into a curing channel, and gradually solidifying the hyaluronic acid sodium in the wrapping phase by controlling the temperature and time to form hyaluronic acid sodium wrapped chenopodium oil microbeads; (3) adding a thickening agent to a reaction kettle, heating to 70-80°C, stirring until completely dissolved, and keeping warm for 10-15 minutes to obtain an aqueous phase; (4) cooling to 50-60°C, adding a surfactant to the aqueous phase, and stirring until uniform at a stirring rate of 300-400 r / min for 10-15 minutes; (5) continuing to cool to 40-45°C, adding a humectant and a preservative, and stirring until uniform at a stirring rate of 200-300 r / min for 5-10 minutes; (6) cooling to 30-35°C, adding hyaluronic acid sodium wrapped chenopodium oil microbeads, and stirring until mixed uniformly at a stirring rate of 100-150 r / min for 5-10 minutes; (7) adjusting the pH value of the system to 5.5-6.5 with a pH regulator to obtain a hyaluronic acid sodium wrapped chenopodium oil microbead stable anti-dandruff composition.

10. The method of preparing a stable anti-dandruff composition of sodium hyaluronate-coated microbeads of cedrol according to claim 9, characterized in that, The base oil is at least one of caprylic acid / capric acid triglyceride, tea seed oil, the antioxidant is rosemary extract, the ultraviolet absorbing component is at least one of benzophenone-4, pomegranate peel extract, ginger root extract, titanium dioxide, zinc dioxide, the particle solidifying component is at least one of sodium alginate, carrageenan, xanthan gum, agar.

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