Anti-leakage suture loaded with cross-linking coating and preparation method of anti-leakage suture

Abstract

The invention belongs to the technical field of medical instruments, and particularly relates to a cross-linked coating loaded anti-leakage suture which comprises a suture body, a bottom activation layer and a top coating, and the bottom activation layer and the top coating are located on the surface of the suture body. The bottom activation layer comprises the following components in parts by mass: 1-10 parts of a cross-linking agent A, 0.1-3 parts of a pH regulator, 20-50 parts of ethanol and 100-200 parts of purified water; the top coating is prepared from the following components in parts by mass: 10 to 40 parts of monomer, 0.5 to 3 parts of cross-linking agent B, 1 to 20 parts of hydrophilic macromolecule, 0.1 to 5 parts of photoinitiator and 30 to 100 parts of purified water; the invention also provides a specific preparation method. The defects of an existing suture are overcome, the bottom activation layer and the base material are covalently bonded, the top layer and the bottom layer are crosslinked and combined through ultraviolet light initiation, meanwhile, the coating can be adhered to tissue, can be swelled and can be firmly combined with the suture, and the suture is endowed with tissue grasping force and anti-leakage performance.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of medical devices, and particularly relates to a leakage-proof suture loaded with a cross-linked coating and a preparation method thereof. BACKGROUND

[0002] Surgical suturing is an important link in the medical field, and the performance of the suture directly affects the operation effect and postoperative recovery of the patient. Traditional sutures have a large number of deficiencies in clinical application, such as firmness in tissue suturing, leakage prevention effect and operation convenience. The current surgical suture realizes tissue fixation through knotting, which is time-consuming and may cause postoperative leakage, poor tissue healing or even complications due to loose knotting or suture slippage. In addition, the needle eye formed by the suture when piercing the tissue also becomes a channel for liquid leakage, further increasing the risk of infection or delaying wound healing. Therefore, the leakage prevention performance and knot-free function of the suture have gradually become the focus of development to meet the clinical needs. Among them, the coated suture has become a research focus due to its simple technology and strong feasibility. For example, biocompatible materials are used as coatings to reduce tissue reactions, or physical modification methods are used to enhance the mechanical strength of the suture. However, the current coated suture still has the following problems: 1. Poor stability and durability of the coating. The coated suture is prone to coating peeling and uneven degradation rate under the body fluid environment or mechanical stress, resulting in a decrease in the performance of the suture during the critical healing period after the operation, and the suture cannot continuously provide effective tissue holding force or leakage prevention effect; 2. It is difficult to balance the tissue holding force and the performance of blocking the needle eye. Some sutures increase the surface roughness of the tissue holding force, but may aggravate tissue damage, while the risk of blocking the needle eye may affect the flexibility of the suturing operation due to the insufficient softness of the coating material; 3. Process limitations lead to performance defects; traditional coating processes cannot achieve uniform distribution of the coating on the surface of the suture and precise control of the microstructure, resulting in local performance differences; the cross-linking process is not mature, and existing thermal cross-linking or chemical cross-linking methods may damage the performance of the suture substrate or introduce harmful substances, affecting biological safety; 4. There is an operation risk in the knot-free design: the knot-free risk of some depends on special structure design, but such structure may increase the risk of tissue cutting, and has limited adaptability in fragile tissues. Therefore, there is an urgent need for a knot-free suture in the market that can reduce suture slippage and reduce the risk of leakage. SUMMARY

[0003] In view of the problems in the prior art, the present application provides a knot-free leakage-proof suture loaded with a cross-linked coating, which solves the defects of the existing suture. The bottom activation layer is covalently bonded to the substrate, and the top layer is combined with the bottom layer by ultraviolet light-induced cross-linking. At the same time, the coating can adhere to the tissue, swell, and firmly combine with the suture, giving the suture tissue holding force and leakage prevention performance.

[0004] To achieve the above technical purposes, the technical scheme of the present application is: The load cross-linking coating knot-free anti-leakage suture comprises a suture and a bottom layer activation layer and a top layer coating layer on the surface of the suture; the bottom layer activation layer introduces active groups to the suture substrate to improve the connection effect of the top layer coating and the surface of the suture; and the top layer coating provides tissue gripping force and plugging properties for the suture.

[0005] The suture material is selected from one of poly-p-dioxanone, polyglycolic acid or polypropylene.

[0006] The mass ratio of the bottom layer activation layer is 1-10 parts of cross-linking agent A, 0.1-3 parts of pH regulator, 20-50 parts of ethanol and 100-200 parts of purified water.

[0007] The cross-linking agent A is one of 3-(isobutenyl) propyl trimethoxysilane, 3-(methacryloyl) propyl trimethoxysilane, vinyl trimethoxysilane and vinyl triethoxysilane.

[0008] The pH regulator is at least one of acetic acid, hydrochloric acid, phosphoric acid, acetate and phosphate.

[0009] The mass ratio of the top layer coating is 10-40 parts of monomer, 0.5-3 parts of cross-linking agent B, 1-20 parts of hydrophilic macromolecule, 0.1-5 parts of photoinitiator and 30-100 parts of purified water.

[0010] The monomer is composed of network support monomer, adhesive monomer and water-hydrated layer breaking monomer; the network support monomer is one or more of acrylic acid, hydroxyethyl acrylate, hydroxyethyl methacrylate, methyl acrylate and ethyl acrylate, accounting for 80-90% of the total mass of the monomer; the adhesive monomer is one or more of N-acryloyl succinimidyl ester, N-succinimidyl methacrylate, succinimide derivative, dopamine and catechol derivative, accounting for 1-10% of the total mass of the monomer; the water-hydrated layer breaking monomer is one or more of cationic compound, thioctic acid and derivative thereof, accounting for 1-10% of the total mass of the monomer; and the cationic compound includes methacryloyloxyethyl trimethyl ammonium chloride, acryloyloxyethyl trimethyl ammonium chloride and N,N-dimethyl-N-benzyl-acryloyloxy ammonium chloride.

[0011] The cross-linking agent B is one or more of N,N'-ethylene bisacrylamide, N,N'-methylene bisacrylamide, trimethylolpropane triacrylate, pentaerythritol tetraacrylate and polyethylene glycol diacrylate.

[0012] The hydrophilic macromolecule is one of polyethylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, sodium alginate, gelatin, chitosan and xanthan gum.

[0013] The photo initiator is at least one of 4-(2-hydroxyethoxymethyl) benzophenone, 2-hydroxy-2-methyl-1-[4-(2-hydroxyethoxy) phenyl]-1-propanone, 2-hydroxy-2-methyl-1-[4-methylvinyl-phenyl] propanone, alpha-ketoglutaric acid, ammonium persulfate.

[0014] The preparation method of the knot-free anti-leakage suture with the cross-linked coating comprises coating a bottom activation layer and a top coating layer on the surface of the suture, and the specific steps comprise: Step 1, the suture is subjected to plasma treatment, and the parameters of the plasma treatment are as follows: the gas source is O2, NH3 or Ar, the power is 50-500 W, and the time is 90-600 s; Step 2, the raw materials are weighed according to the mass ratio of the bottom activation layer, and are uniformly mixed to obtain a bottom activation layer slurry; Step 3, the suture subjected to the plasma treatment is soaked in the bottom activation layer slurry, and then is taken out and dried in a constant-temperature vacuum drying box to obtain a primary plated suture, and the parameters of the constant-temperature vacuum drying box are as follows: 25 DEG C, vacuum, and 8-16 h; Step 4, the raw materials are weighed according to the mass ratio of the top coating layer, and are uniformly mixed to obtain a top coating layer slurry; Step 5, the top coating layer is coated on the surface of the primary plated suture by means of immersion, and after ultraviolet curing, the suture is dried in a constant-temperature vacuum drying box to obtain a knot-free anti-leakage suture, and the parameters of the ultraviolet curing are as follows: wavelength 365 nm, light intensity 500-2000 mW / cm2, and time 2-30 s; the parameters of the constant-temperature vacuum drying box are as follows: 25 DEG C, vacuum, and 8-16 h.

[0015] The coating structure in the technical solution is a semi-interpenetrating network structure, the cross-linked network structure is used as a skeleton support, hydrophilic macromolecules interpenetrate between the skeleton networks, swelling space is provided, and lubrication is provided for suturing. When the suture is implanted into a tissue, the adhesion groups in the coating can form covalent bonds with the tissue in a few minutes, in addition, the hydrophilic groups in the coating can form hydrogen bonds with the tissue, and dynamic adhesion is realized. On the other hand, the preparation process is to enhance the surface energy of the base material by means of plasma treatment, the surface of the suture after pretreatment is modified with ultraviolet light curing active groups as the bottom activation layer, and participates in the curing process of the top coating layer, so that the coating and the base material form covalent cross-linking, and the adhesion firmness of the coating is ensured.

[0016] As can be seen from the above description, the present application has the following advantages: 1. The present application solves the defects of the existing suture, utilizes the covalent bonding between the bottom activation layer and the substrate, and the top layer is combined with the bottom layer by ultraviolet light induced crosslinking, at the same time, the coating can adhere to the tissue, can swell, and is firmly combined with the suture, which gives the suture tissue gripping force and anti-leakage performance.

[0017] 2. The present application realizes the tissue gripping force through the synergistic effect of succinimide ester bond (covalent adhesion) and hydrophilic group (hydrogen bond), and the adhesion strength reaches 40 kPa in 30 min, and the adhesion strength gradually increases with the swelling of the coating.

[0018] 3. The present application adopts a semi-interpenetrating network, and the maximum radial swelling can reach 200%, that is, the needle hole is immediately plugged, and the burst strength is more than 80 kPa.

[0019] 4. The crosslinked coating of the present application loses mechanical strength after 5 weeks of degradation, which meets the healing period. DETAILED DESCRIPTION

[0020] The present application is described in detail in combination with examples, but does not limit the claims of the present application in any way.

[0021] Example 1 A preparation method of a non-knotting anti-leakage suture loaded with a crosslinked coating comprises coating a bottom activation layer and a top coating on the surface of the suture, and the specific steps comprise: Step 1, the suture is subjected to plasma treatment, and the parameters of the plasma treatment are as follows: the gas source is O2, the power is 100 W, and the time is 90 s; Step 2, the raw materials are weighed according to the mass ratio of the bottom activation layer, and are uniformly mixed to obtain a bottom activation layer slurry; the mass ratio of the bottom activation layer is as follows: 5 parts by weight of 3-(isobutenoyloxy) propyl trimethoxysilane, 0.2 parts by weight of acetic acid, 20 parts by weight of ethanol and 100 parts by weight of purified water; Step 3, the plasma-treated suture is soaked in the bottom activation layer slurry, and then taken out and dried in a constant temperature vacuum drying oven to obtain a primary plated suture; the parameters of the constant temperature vacuum drying oven are as follows: 25℃, vacuum, 12 h; Step 4, the raw materials are weighed according to the mass ratio of the top coating, and are uniformly mixed to obtain a top coating slurry; the mass ratio of the top coating is as follows: 40 parts by weight of acrylic acid, 1 part by weight of N-acryloyloxy succinimide ester, 0.1 part by weight of methacryloyloxyethyl trimethyl ammonium chloride, 0.5 part by weight of polyethylene glycol diacrylate, 5 parts by weight of polyvinyl alcohol, 0.1 part by weight of 4-(2-hydroxyethoxymethyl) benzophenone and 50 parts by weight of purified water; Step 5, the top layer coating is coated on the surface of the primary plated suture by leaching, and after ultraviolet curing, it is placed in a constant temperature vacuum drying oven for drying to obtain the knotless anti-leakage suture, the parameters of the ultraviolet curing are: wavelength 365 nm, light intensity 500 mW / cm2, 20 s; the parameters of the constant temperature vacuum drying oven are: 25℃, vacuum, 12 h.

[0022] The 4-0 suture tissue gripping force prepared in this example is 1.1 N, the swelling is 150%, and the burst strength is 80 kPa.

[0023] Example 2 A preparation method of a knotless anti-leakage suture loaded with a cross-linked coating includes coating a bottom layer activation layer and a top layer coating on the surface of the suture, and the specific steps include: Step 1, the suture is plasma treated, and the parameters of the plasma treatment are: Ar is used as the gas source, the power is 300 W, and the time is 300 s; Step 2, the raw materials are weighed according to the mass ratio of the bottom layer activation layer, and are uniformly mixed to obtain a bottom layer activation layer slurry; the mass ratio of the bottom layer activation layer is: 4 parts by weight of 3-(methacryloyloxy) propyl trimethoxysilane, 0.2 parts by weight of phosphoric acid, 10 parts by weight of ethanol and 110 parts by weight of purified water; Step 3, the plasma treated suture is soaked in the bottom layer activation layer slurry, and then taken out and placed in a constant temperature vacuum drying oven for drying to obtain a primary plated suture; the parameters of the constant temperature vacuum drying oven are: 25℃, vacuum, 12 h; Step 4, the raw materials are weighed according to the mass ratio of the top layer coating, and are uniformly mixed to obtain a top layer coating slurry; the mass ratio of the top layer coating is: 35 parts by weight of hydroxyethyl acrylate, 5 parts by weight of N-acryloyloxy succinimide ester, 1 part by weight of N,N'-ethylene bisacrylamide, 5 parts by weight of gelatin, 0.5 parts by weight of alpha-ketoglutaric acid and 60 parts by weight of purified water; Step 5, the top layer coating is coated on the surface of the primary plated suture by leaching, and after ultraviolet curing, it is placed in a constant temperature vacuum drying oven for drying to obtain the knotless anti-leakage suture, the parameters of the ultraviolet curing are: wavelength 365 nm, light intensity 1000 mW / cm2, 15 s; the parameters of the constant temperature vacuum drying oven are: 25℃, vacuum, 12 h.

[0024] The 4-0 suture tissue gripping force prepared in this example is 1.4 N, the swelling is 200%, and the burst strength is 90 kPa.

[0025] Example 3 A preparation method of a knotless anti-leakage suture loaded with a cross-linked coating includes coating a bottom layer activation layer and a top layer coating on the surface of the suture, and the specific steps include: Step 1, the suture is plasma treated, the parameters of the plasma treatment are: O2 is used as the gas source, the power is 100 W, and the time is 100 s; Step 2, the raw materials are weighed according to the mass ratio of the bottom activation layer and uniformly mixed to obtain a bottom activation layer slurry; the mass ratio of the bottom activation layer is: 5 parts by weight of 3-mercaptopropyl triethoxysilane, 0.5 parts by weight of phosphate, and 100 parts by weight of purified water; Step 3, the plasma-treated suture is soaked in the bottom activation layer slurry, then taken out and dried in a constant temperature vacuum drying oven to obtain a primary plated suture; the parameters of the constant temperature vacuum drying oven are: 25℃, vacuum, 12h; Step 4, the raw materials are weighed according to the mass ratio of the top coating and uniformly mixed to obtain a top coating slurry; the mass ratio of the top coating is: 25 parts by weight of ethyl acrylate, 4.5 parts by weight of N-succinimidyl methacrylate, 0.1 parts by weight of trimethylolpropane triacrylate, 10 parts by weight of polyethylene glycol, 3 parts by weight of 2-hydroxy-2-methyl-1-[4-(2-hydroxyethoxy)phenyl]-1-propanone, and 40 parts by weight of purified water; Step 5, the top coating is coated on the surface of the primary plated suture by leaching, and after ultraviolet curing, it is dried in a constant temperature vacuum drying oven to obtain a knotless anti-leakage suture, the parameters of the ultraviolet curing are: wavelength 365 nm, light intensity 1500 mW / cm2, 10 s; the parameters of the constant temperature vacuum drying oven are: 25℃, vacuum, 16h.

[0026] The 4-0 suture tissue grip force prepared in this example is 0.9 N, the swelling is 170%, and the burst strength is 80 kPa.

[0027] Comparative Example 1 A preparation method of a knotless anti-leakage suture loaded with a cross-linked coating includes coating a bottom activation layer and a top coating on the surface of a suture, and the specific steps include: Step 1, the suture is plasma treated, the parameters of the plasma treatment are: O2 is used as the gas source, the power is 100 W, and the time is 100 s; Step 2, the raw materials are weighed according to the mass ratio of the bottom activation layer and uniformly mixed to obtain a bottom activation layer slurry; the mass ratio of the bottom activation layer is: 5 parts by weight of 3-mercaptopropyl triethoxysilane, 0.5 parts by weight of phosphate, and 100 parts by weight of purified water; Step 3, the plasma-treated suture is soaked in the bottom activation layer slurry, then taken out and dried in a constant temperature vacuum drying oven to obtain a primary plated suture; the parameters of the constant temperature vacuum drying oven are: 25℃, vacuum, 12h; Step 4, the raw materials are weighed according to the mass ratio of the top coating, and are uniformly mixed to obtain a top coating slurry; the mass ratio of the top coating is: 50 parts by weight of ethyl acrylate, 4.5 parts by weight of N-succinimidyl methacrylate, 5 parts by weight of trimethylolpropane triacrylate, 10 parts by weight of polyethylene glycol, 3 parts by weight of 2-hydroxy-2-methyl-1-[4-(2-hydroxyethoxy)phenyl]-1-propanone and 40 parts by weight of purified water; Step 5, the top coating is coated on the surface of the primary plated suture by leaching, and after ultraviolet curing, it is dried in a constant temperature vacuum drying oven to obtain a knotless anti-leakage suture, the parameters of the ultraviolet curing are: wavelength 365 nm, light intensity 1500 mW / cm2, 10 s; the parameters of the constant temperature vacuum drying oven are: 25℃, vacuum, 16 h.

[0028] The 4-0 suture tissue gripping force prepared in this example is 0.3 N, the swelling is 60%, and the burst strength is 30 kPa.

[0029] Comparative Example 2 A preparation method of a knotless anti-leakage suture loaded with a cross-linked coating includes coating a bottom activation layer and a top coating on the surface of a suture, and the specific steps include: Step 1, the suture is subjected to plasma treatment, and the parameters of the plasma treatment are: O2 is used as the gas source, the power is 100 W, and the time is 100 s; Step 2, the raw materials are weighed according to the mass ratio of the bottom activation layer, and are uniformly mixed to obtain a bottom activation layer slurry; the mass ratio of the bottom activation layer is: 5 parts by weight of 3-mercaptopropyl triethoxysilane, 0.5 parts by weight of phosphate, and 100 parts by weight of purified water; Step 3, the plasma-treated suture is soaked in the bottom activation layer slurry, and then taken out and dried in a constant temperature vacuum drying oven to obtain a primary plated suture; the parameters of the constant temperature vacuum drying oven are: 25℃, vacuum, 12 h; Step 4, the raw materials are weighed according to the mass ratio of the top coating, and are uniformly mixed to obtain a top coating slurry; the mass ratio of the top coating is: 10 parts by weight of ethyl acrylate, 10 parts by weight of N-succinimidyl methacrylate, 5 parts by weight of trimethylolpropane triacrylate, 20 parts by weight of polyethylene glycol, 2 parts by weight of 2-hydroxy-2-methyl-1-[4-(2-hydroxyethoxy)phenyl]-1-propanone and 40 parts by weight of purified water; Step 5, coating the top layer coating on the surface of the initial plated suture by leaching, after ultraviolet curing, placing it in a constant temperature vacuum drying oven to dry, obtaining the knotless anti-leakage suture, the parameters of the ultraviolet curing are: wavelength 365 nm, light intensity 500-2000 mW / cm2, 2-30 s; the parameters of the constant temperature vacuum drying oven are: 25℃, vacuum, 16 h.

[0030] The 4-0 suture tissue gripping force prepared in this example is 0.5 N, the swelling is 75%, and the burst strength is 35 kPa.

[0031] Comparative Example 3 A method for preparing a knotless anti-leakage suture loaded with a cross-linked coating includes coating a bottom activation layer and a top layer coating on the surface of the suture, and the specific steps include: Step 1, plasma treatment of the suture, the parameters of the plasma treatment are: O2 as the gas source, power 100 W, time 100 s; Step 2, according to the mass ratio of the bottom activation layer, the raw materials are weighed and uniformly mixed to obtain the bottom activation layer slurry; the mass ratio of the bottom activation layer is: 5 parts by weight of γ-aminopropyltriethoxysilane, 0.5 parts by weight of phosphate, 100 parts by weight of purified water; Step 3, soaking the plasma-treated suture in the bottom activation layer slurry, then taking it out and placing it in a constant temperature vacuum drying oven to dry, obtaining the initial plated suture; the parameters of the constant temperature vacuum drying oven are: 25℃, vacuum, 12 h; Step 4, according to the mass ratio of the top layer coating, the raw materials are weighed and uniformly mixed to obtain the top layer coating slurry; the mass ratio of the top layer coating is: 25 parts by weight of ethyl acrylate, 4.5 parts by weight of N-succinimidyl methacrylate, 0.1 parts by weight of trimethylolpropane triacrylate, 10 parts by weight of polyethylene glycol, 3 parts by weight of 2-hydroxy-2-methyl-1-[4-(2-hydroxyethoxy)phenyl]-1-propanone, and 40 parts by weight of purified water; Step 5, coating the top layer coating on the surface of the initial plated suture by leaching, after ultraviolet curing, placing it in a constant temperature vacuum drying oven to dry, obtaining the knotless anti-leakage suture, the parameters of the ultraviolet curing are: wavelength 365 nm, light intensity 1500 mW / cm2, 10 s; the parameters of the constant temperature vacuum drying oven are: 25℃, vacuum, 16 h.

[0032] The 4-0 suture tissue gripping force prepared in this example is 0.22 N, the swelling is 175%, and the burst strength is 25 kPa.

[0033] The suture prepared in Examples 1-3 and Comparative Examples 1-3 above is used as the detection object for performance testing (tissue gripping force, swelling rate, burst strength), and the specific performance testing is as follows: (1) Tissue grip test Sample preparation: Thread the suture through a U-shaped loop in a simulated tissue (e.g. silicone or animal tissue), ensuring that the suture is embedded in the tissue. Secure both ends of the suture to the clamps of a mechanical testing machine, keeping the U-shaped loop perpendicular to the direction of force. Mechanical testing: Stretch the suture at a constant rate (e.g. 200 mm / min) and record the maximum force value until the suture slips or breaks. Repeat the test at least 10 times and take the average value to improve data reliability. (2) Swelling rate test Sample preparation: Treat the suture sample under specific conditions (e.g. drying) until the mass stabilizes, and measure its initial thread diameter (diameter).

[0034] Soaking treatment: Soak the suture sample in a selected solvent (e.g. phosphate buffer solution PBS, pH 7.4) at a constant temperature (e.g. 37°C).

[0035] Periodic measurement: Take out the suture sample every certain time, gently absorb the surface moisture with filter paper, and then measure its thread diameter.

[0036] Data calculation: Calculate the swelling rate according to the measured data.

[0037] (3) Burst strength test Refer to ASTM F2392 04 Standard Test Method for Burst Strength of Surgical Sealants for testing.

[0038] According to the comparison of Example 3 and Comparative Example 1, Comparative Example 2, and Comparative Example 3, the monomer content in Comparative Example 1 is too high, the coating strength is low, and thus the tissue grip and sealing performance are affected; Comparative Example 2 lacks a broken hydration layer monomer, the coating is affected by tissue fluid, and the adhesion decreases; Comparative Example 3 uses other bottom active monomers, which cannot participate in the top ultraviolet curing, and the coating is easy to fall off, thus affecting the performance. Therefore, the coating includes a bottom active layer and a top coating layer, the formula of the bottom active layer includes 1-10 parts by weight of crosslinking agent A, 0.1-3 parts by weight of pH adjuster, 20-50 parts by weight of ethanol, and 100-200 parts by weight of purified water; the formula of the top coating layer includes 10-40 parts by weight of monomer, 0.5-3 parts by weight of crosslinking agent B, 1-20 parts by weight of hydrophilic macromolecule, 0.1-5 parts by weight of photoinitiator, and 30-100 parts by weight of purified water, which is the best scheme.

[0039] It can be understood that the above specific description of the present application is only for illustrating the present application and is not limited to the technical solutions described in the embodiments of the present application. It should be understood by those skilled in the art that the present application can still be modified or replaced equivalently to achieve the same technical effects; as long as the use needs are met, it is within the protection scope of the present application.

Claims

1. A knotless barrier suture loaded with a crosslinked coating, characterized in that: The application relates to a suture and a bottom layer activation layer and a top layer coating on the surface of the suture; the mass ratio of the bottom layer activation layer is as follows: 1-10 parts of a crosslinking agent A, 0.1-3 parts of a pH regulator, 20-50 parts of ethanol and 100-200 parts of purified water; the mass ratio of the top layer coating is as follows: 10-40 parts of a monomer, 0.5-3 parts of a crosslinking agent B, 1-20 parts of a hydrophilic macromolecule, 0.1-5 parts of a photoinitiator and 30-100 parts of purified water. The suture material is selected from one of poly-p-dioxanone, polyglycolic acid and polypropylene.

2. The knotless barrier suture loaded with a crosslinked coating according to claim 1, characterized in that: The crosslinking agent A is one of 3-(isobutenyl acryloxy) propyl trimethoxysilane, 3-(methacryloxy) propyl trimethoxysilane, vinyl trimethoxysilane and vinyl triethoxysilane.

3. The knotless barrier suture loaded with a crosslinked coating according to claim 1, characterized in that: The pH regulator is at least one of acetic acid, hydrochloric acid, phosphoric acid, acetate and phosphate.

4. The knotless, barrier suture loaded with a crosslinked coating of claim 1, wherein: The monomer is composed of network support monomer, adhesive monomer and water-hydrated layer breaking monomer; the network support monomer is one or more of acrylic acid, hydroxyethyl acrylate, hydroxyethyl methacrylate, methyl acrylate and ethyl acrylate; the adhesive monomer is one or more of N-acryloyl succinimide ester, N-succinimide methacrylate, succinimide derivative, dopamine and catechol derivative; the water-hydrated layer breaking monomer is one or more of cationic compound, thioctic acid and derivative thereof; the cationic compound includes methacryloxyethyl trimethyl ammonium chloride, acryloxyethyl trimethyl ammonium chloride and N,N-dimethyl-N-benzyl-acryloxy ammonium chloride.

5. The knotless, barrier suture loaded with a crosslinked coating of claim 1, wherein: The crosslinking agent B is one or more of N,N'-ethylene bisacrylamide, N,N'-methylene bisacrylamide, trimethylolpropane triacrylate, pentaerythritol tetraacrylate and polyethylene glycol diacrylate.

6. The knotless barrier suture of claim 1, wherein: The hydrophilic macromolecule is one of polyethylene glycol, polyvinyl alcohol, polyvinyl pyrrolidone, sodium alginate, gelatin, chitosan and xanthan gum.

7. The knotless, barrier suture loaded with a crosslinked coating of claim 1, wherein: The photoinitiator is at least one of 4-(2-hydroxyethoxymethyl) benzophenone, 2-hydroxy-2-methyl-1-[4-(2-hydroxyethoxy) phenyl]-1-propanone, 2-hydroxy-2-methyl-1-[4-methylvinyl-phenyl] propanone, alpha-ketoglutaric acid and ammonium persulfate.

8. The knotless barrier suture of claim 1, wherein: The preparation method of the non-knotting anti-leakage suture with a crosslinking coating comprises coating a bottom layer activation layer and a top layer coating on the surface of the suture, and the specific steps are as follows:

9. The knotless barrier suture loaded with a crosslinked coating according to claim 1, wherein: Step 1: the suture is subjected to plasma treatment, and the plasma treatment parameters are as follows: the gas source is O2, NH3 or Ar, the power is 50-500 W and the time is 90-600 s; Step 2: the raw materials are weighed according to the mass ratio of the bottom layer activation layer and are uniformly mixed to obtain a bottom layer activation layer slurry; Step 3: the plasma-treated suture is soaked in the bottom layer activation layer slurry, and then is taken out and dried in a constant-temperature vacuum drying box to obtain a primary plated suture; the parameters of the constant-temperature vacuum drying box are as follows: 25 DEG C, vacuum and 8-16 h. ​ Step 4, the raw materials are weighed according to the quality ratio of the top coating, mixed uniformly to obtain a top coating slurry; Step 5, the top coating is coated on the surface of the primary plated suture by leaching, and after UV curing, the suture is dried in a constant temperature vacuum drying oven to obtain a knot-free and anti-leakage suture, wherein the parameters of the UV curing are: wavelength 365 nm, light intensity 500-2000 mW / cm2, 2-30 s; and the parameters of the constant temperature vacuum drying oven are: 25℃, vacuum, 8-16 h.