A wet granulation mixer for pharmaceuticals and a method thereof

Abstract

The application relates to the technical field of medicine granulation, in particular to a medicine wet mixing granulator and a method thereof. The granulator comprises a granulation barrel, a scattering mechanism, a servo motor installed on the granulation barrel, an output shaft of the servo motor, a mounting frame, a centrifugal barrel, a coil spring, a connecting pipe, a filter cloth bag and an impact mechanism. The medicine particles in the filter cloth bag fall into the centrifugal barrel through the design of the impact mechanism and the scattering mechanism. When the centrifugal barrel rotates at high speed, the medicine particles in the centrifugal barrel are thrown out of the centrifugal barrel under the action of centrifugal force, and the medicine particles can be dispersed in the granulation barrel, so that the medicine particles in the granulation barrel are more uniform.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical granulation technology, and more particularly to a wet mixing granulation machine and method for pharmaceuticals. Background Technology

[0002] The main steps in pharmaceutical granulation include mixing, wet granulation, drying, and sieving. These steps can improve the stability, solubility, and taste of drugs, promote drug absorption, and reduce drug side effects. Granulation processes produce granular materials, which can improve the stability of drugs and extend their shelf life.

[0003] Current pharmaceutical granulation equipment requires filtration through filter bags during the granulation process. Due to the structural characteristics of the filter bags, they can become clogged after prolonged use. This can cause excessive internal pressure in the wet mixing granulator, leading to material leakage along the gaps. In such cases, the wet mixing granulator needs to be shut down and the filter bags cleaned by staff. Summary of the Invention

[0004] To overcome the drawback of bag filters being prone to clogging, leading to excessive internal pressure in wet mixing granulation machines, this invention provides a wet mixing granulation machine and method for pharmaceuticals.

[0005] The technical solution of the present invention is as follows: a wet mixing granulator for pharmaceuticals, including a granulation barrel and a dispersing mechanism. The dispersing mechanism includes a servo motor mounted on the granulation barrel. The output shaft of the servo motor rotates through the granulation barrel and is fixedly mounted on a mounting frame. A centrifuge barrel is rotatably mounted inside the mounting frame. A coil spring is provided between the centrifuge barrel and the mounting frame. A connecting pipe is symmetrically connected to the granulation barrel. A filter bag is connected to the connecting pipe and an impact mechanism is provided.

[0006] More preferably, the bulk material handling mechanism also includes a swing plate that is elastically hinged inside the centrifuge drum.

[0007] More preferably, the bulk material mechanism also includes friction strips symmetrically fixedly installed inside the pelleting barrel, and a friction ring that cooperates with the friction strips is fixedly sleeved on the centrifuge barrel.

[0008] More preferably, the impact mechanism includes two brackets fixedly installed on the granulation barrel, the filter bag is fixedly installed on the brackets, the outer wall of the connecting pipe is rotatably fitted with a rotating frame, and several elastic sliding rods are elastically slidably installed on the rotating frame in the horizontal direction. The ends of the several elastic sliding rods are all fixedly installed with vertical plates, and several top rods that cooperate with the filter bag are fixedly installed on the vertical plates.

[0009] More preferably, the impact mechanism also includes a first wedge block that is elastically hinged to one side of the vertical plate, and a number of second wedge blocks are fixedly installed on the outer wall of the connecting pipe, with the first wedge block cooperating with the number of second wedge blocks.

[0010] More preferably, the impact mechanism also includes a C-shaped frame fixedly installed on the pelletizing barrel, a rotating shaft driven by a servo motor is rotatably installed inside the C-shaped frame, a through groove is opened on the rotating shaft, a lever is slidably installed in the through groove, and a friction rod is elastically slidably installed on the bracket, the friction rod cooperating with the rotating frame and the lever.

[0011] More preferably, a sliding shaft is fixedly installed at the bottom of the lever, and a guide groove is provided on the C-shaped frame, with the sliding shaft located in the guide groove.

[0012] More preferably, the guide groove is elliptical.

[0013] More preferably, the sliding shaft cooperates with the guide groove, so that the lever reciprocates along the through groove of the rotating shaft.

[0014] A method for wet mixing and granulating a pharmaceutical product using the aforementioned wet mixing and granulating machine includes the following steps:

[0015] S1: The servo motor controls the mounting bracket to drive the centrifuge barrel to move, so that the top axis of the centrifuge barrel coincides with the axis of the connecting pipe. The swing plate blocks the airflow, causing the medicine particles in the filter bag to fall.

[0016] S2: The friction bar and friction ring work together to store energy in the coil spring. When the friction ring passes the friction bar, it causes the centrifuge to rotate at high speed and throw out the drug particles.

[0017] S3: Through the cooperation of the first wedge block and the second wedge block, the elastic slide bar can quickly and elastically contract and slide, causing the medicine particles stuck in the gap of the filter bag to fall off.

[0018] Compared with the prior art, the present invention has the following advantages:

[0019] 1. The present invention, through the design of the impact mechanism and the dispersing mechanism, allows the drug particles in the filter bag to fall into the centrifuge barrel. When the centrifuge barrel rotates at high speed, the drug particles in the centrifuge barrel are thrown out of the centrifuge barrel under the action of centrifugal force, and the drug particles are dispersed in the granulation barrel, making the drug particles in the granulation barrel more uniform.

[0020] 2. The present invention, through the design of the swing plate, when the swing plate is in a vertical state, blocks the airflow in the granulation barrel, preventing the airflow from entering the filter bag through the centrifuge barrel and connecting pipe, so that the drug particles in the filter bag can fall normally.

[0021] 3. Through the design of the impact mechanism, the output shaft of the servo motor drives the mounting frame to rotate, which in turn drives the lever to move. Through the cooperation of the lever and the friction rod, the rotating frame rotates. When the lever passes the friction rod, through the cooperation of the first wedge block and the second wedge block, the top rod impacts the outer wall of the filter bag, causing the medicine particles stuck in the gap of the filter bag to fall off and fall into the centrifuge tank through the connecting pipe. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the overall structure of the present invention;

[0023] Figure 2 This is a schematic diagram of the material handling mechanism in this invention;

[0024] Figure 3 This is a schematic diagram of the installation at the mounting bracket in this invention;

[0025] Figure 4 This is a schematic diagram of the installation of the swing plate in this invention;

[0026] Figure 5 This is a schematic diagram of the installation of the friction strip in this invention. Figure 1 ;

[0027] Figure 6 This is a schematic diagram of the installation of the friction strip in this invention. Figure 2 ;

[0028] Figure 7 This is a schematic diagram of the impact mechanism in this invention;

[0029] Figure 8 This is a schematic diagram of the installation of the elastic slide bar in this invention;

[0030] Figure 9 This is a schematic diagram of the installation at the rotating shaft in this invention;

[0031] Figure 10 This is a schematic diagram of the installation of the lever in this invention;

[0032] Figure 11 This is a schematic diagram of the installation at the sliding shaft in this invention;

[0033] Figure 12 This is a schematic diagram of the structure of the guide groove in this invention.

[0034] The components in the attached diagram are labeled as follows: 1. Granulation barrel; 201. Servo motor; 202. Mounting frame; 203. Centrifuge barrel; 204. Connecting pipe; 205. Filter bag; 301. Swing plate; 401. Friction strip; 402. Friction ring; 501. Support; 502. Rotating frame; 503. Elastic slide bar; 504. Vertical plate; 505. Top rod; 601. First wedge block; 602. Second wedge block; 701. C-shaped frame; 702. Rotating shaft; 703. Actuating rod; 704. Friction rod; 801. Slide shaft; 802. Guide groove. Detailed Implementation

[0035] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0036] A wet mixing granulation machine for a drug, such as Figures 1-3 As shown, the device includes a pelletizing drum 1 and a dispersing mechanism. The dispersing mechanism includes a servo motor 201 mounted on the pelletizing drum 1. The servo motor 201 is a dual-axis motor. The bottom output shaft of the servo motor 201 rotates through the pelletizing drum 1 and is fixedly mounted on a mounting frame 202. A centrifuge drum 203 is rotatably mounted inside the mounting frame 202. A coil spring is provided between the outer wall of the centrifuge drum 203 and the inner wall of the mounting frame 202. A connecting pipe 204 is symmetrically connected to the top of the pelletizing drum 1. A filter bag 205 is connected to the top of the connecting pipe 204 and is equipped with an impact mechanism.

[0037] like Figure 4 As shown, the bulk material mechanism also includes a swing plate 301 that is elastically hinged inside the centrifuge barrel 203. When the swing plate 301 is in a vertical state, the swing plate 301 blocks the airflow inside the granulation barrel 1, and the airflow inside the granulation barrel 1 cannot enter the centrifuge barrel 203.

[0038] like Figure 2 and Figure 3 As shown, the bulk material mechanism also includes friction strips 401 symmetrically fixedly installed on the upper part of the inner wall of the pelleting barrel 1, and a friction ring 402 that cooperates with the friction strips 401 is fixedly sleeved on the centrifuge barrel 203. Through the cooperation of the friction strips 401 and the friction ring 402, the coil spring stores energy.

[0039] like Figures 6-8As shown, the impact mechanism includes two brackets 501 fixedly installed on the top of the granulation barrel 1. The filter bag 205 is fixedly installed on the brackets 501. A rotating frame 502 is rotatably sleeved on the upper part of the outer wall of the connecting pipe 204. Four elastic sliding rods 503 are elastically slidably installed on the rotating frame 502 in the horizontal direction. Vertical plates 504 are fixedly installed at the ends of the four elastic sliding rods 503 that are close to each other. Four top rods 505 that cooperate with the filter bag 205 are fixedly installed on the side of the vertical plate 504 near the filter bag 205.

[0040] like Figure 7 and Figure 8 As shown, the impact mechanism also includes a first wedge block 601 that is elastically hinged to the side of the vertical plate 504 near the filter bag 205. Four sets of second wedge blocks 602 located on the upper side of the rotating frame 502 are fixedly installed on the outer wall of the connecting pipe 204, with six in each set. The first wedge block 601 cooperates with the second wedge block 602.

[0041] like Figures 9-12 As shown, the impact mechanism also includes a C-shaped frame 701 fixedly installed on the top of the granulation barrel 1. A rotating shaft 702 driven by a servo motor 201 is rotatably installed inside the C-shaped frame 701. A through groove is provided on the rotating shaft 702. A lever 703 is slidably installed in the through groove along the horizontal direction. A friction rod 704 is elastically slidably installed on the bracket 501. A rubber ring is provided on the outer wall of the rotating frame 502. There is friction between the friction rod 704 and the rubber ring. When the lever 703 presses the friction rod 704, the friction rod 704 causes the rotating frame 502 to rotate through friction with the rubber ring.

[0042] like Figure 11 and Figure 12 As shown, a sliding shaft 801 is fixedly installed at the bottom of the lever 703, and a guide groove 802 is provided at the top of the C-shaped frame 701. The sliding shaft 801 is located in the guide groove 802, which is elliptical. Through the cooperation of the sliding shaft 801 and the guide groove 802, the lever 703 reciprocates along the through groove of the rotating shaft 702, so that the lever 703 passes over the friction rod 704.

[0043] Initially, the top axis of the centrifuge tank 203 coincides with the axis of the connecting pipe 204 on the right side, the friction ring 402 is in contact with the friction strip 401 on the right side, the coil spring between the centrifuge tank 203 and the mounting bracket 202 is in an energy storage state, and the swing plate 301 is in a vertical state. The granulation tank 1 is started to perform granulation (the granulation operation of the granulation tank 1 is existing technology. During the granulation process of the granulation tank 1, airflow is generated at the bottom of the inner wall of the granulation tank 1 to blow the drug particles upward, which will not be described in detail here). The airflow of the drug in the granulation tank 1 moves from bottom to top. At this time, the swing plate 301 blocks the airflow and drug particles in the granulation tank 1, and the airflow and drug particles cannot enter. Inside the centrifuge tank 203, some drug particles enter the filter bag 205 on the left side through the connecting pipe 204 on the left. The filter bag 205 is used to discharge the airflow inside the granulation tank 1, so that the drug particles can come into contact with fresh airflow, making the drug particles dry faster and the particle size distribution more uniform. As the drug continues to enter the filter bag 205 on the left, the air permeability of the filter bag 205 decreases, controlling the output shaft of the servo motor 201 to rotate. The output shaft of the servo motor 201 drives the mounting frame 202 to rotate clockwise. The mounting frame 202 drives the centrifuge tank 203 to move, and the centrifuge tank 203 drives the swing plate 301 and the friction ring 402 to move. Regarding the movement, it should be noted that the output shaft of the servo motor 201 rotates slowly, resulting in a slow movement speed for the centrifuge drum 203. The swing plate 301 is not affected by centrifugal force and therefore does not move. The friction ring 402 rotates under the action of the right friction strip 401, and the coil spring continues to store energy. Subsequently, the friction ring 402 passes over the right friction strip 401, and the coil spring releases energy, causing the centrifuge drum 203 to rotate at high speed. Due to the low elastic torque of the swing plate 301, it elastically contracts upwards and rotates under the action of centrifugal force until the coil spring is completely released. If there are drug particles inside the centrifuge drum 203, the drug particles are completely ejected from the centrifuge drum 203 under the action of centrifugal force. 03. The swing plate 301 is released elastically and rotated to reset. Then, the friction ring 402 contacts the friction strip 401 on the left. Under the action of the friction strip 401 on the left, the friction ring 402 drives the centrifuge barrel 203 to rotate. The coil spring is stressed and stores energy until the mounting bracket 202 rotates 180 degrees. The top axis of the centrifuge barrel 203 coincides with the axis of the left connecting pipe 204. At this time, the centrifuge barrel 203 and the swing plate 301 cooperate to block the airflow in the granulation barrel 1. The airflow and drug particles can no longer enter the filter bag 205 on the left. The drug particles in the filter bag 205 on the left are no longer affected by the airflow, so as to facilitate the cleaning of the filter bag 205.

[0044] Initially, both the elastic slide bar 503 and the friction bar 704 are in the released state. The output shaft of the servo motor 201 drives the mounting bracket 202 to rotate, which in turn drives the rotating shaft 702 to rotate. The rotating shaft 702 drives the lever 703 to move. The lever 703 drives the slide shaft 801 to slide along the guide groove 802. Under the action of the guide groove 802, the slide shaft 801 drives the lever 703 to gradually extend out of the through groove of the rotating shaft 702. Then, the lever 703 contacts and presses against the outer wall of the friction bar 704 on the left. The friction bar 704 is subjected to force and elastically extends and slides to the right. The rotating bracket 502 on the left rotates clockwise under the action of the friction bar 704, which drives the four elastic slide bars 503 on it to move. The elastic slide bars 503 drive the vertical plate 504 to move. Plate 504 drives the four push rods 505 on it to move with the first wedge block 601. The first wedge block 601 is squeezed and elastically contracted by the nearest second wedge block 602 and rotates. After passing the second wedge block 602, it elastically releases and rotates back to its original position. The first wedge block 601 continues to contact the remaining second wedge blocks 602 and repeats the above steps so that when the rotating frame 502 rotates back to its original position, the push rod 505 will impact the filter bag 205 through the cooperation of the first wedge block 601 and the second wedge block 602. Then, under the action of the guide groove 802, the sliding shaft 801 drives the lever 703 to gradually slide into the through groove of the rotating shaft 702 until the top axis of the centrifuge tank 203 coincides with the axis of the left connecting pipe 204. At this time, When lever 703 passes the friction rod 704 on the left, the friction rod 704 releases its restraint, elastically contracts, and slides back to its original position. The rotating frame 502 on the left rotates counterclockwise under the action of the friction rod 704, causing the four elastic sliding rods 503 on it to move. The elastic sliding rods 503 drive the vertical plate 504 to move, and the vertical plate 504 drives the four top rods 505 on it to move against the first wedge block 601. The first wedge block 601 is pressed by the nearest second wedge block 602, and through the vertical plate 504, the elastic sliding rods 503 elastically extend and slide. Simultaneously, the vertical plate 504 drives the four top rods 505 on it to move away from the filter bag 205 until the first wedge block 601 passes the nearest second wedge block 602. 1. Upon release from restriction, the elastic slide bar 503 rapidly contracts and slides, driving the four push rods 505 and the first wedge block 601 to move via the vertical plate 504. After the four push rods 505 move, they impact the outer wall of the filter bag 205, causing deformation and vibration of the outer wall of the filter bag 205. The medicine particles stuck in the gaps of the filter bag 205 fall off and fall into the centrifuge tank 203 through the connecting pipe 204. After the first wedge block 601 moves, it contacts the next second wedge block 602, and the above steps are repeated to achieve the same effect until the friction rod 704 is reset and the rotating frame 502 stops moving, thus cleaning the filter bag 205, restoring the air permeability of the filter bag 205, and allowing the airflow in the granulation tank 1 to be discharged in time.

[0045] As drug particles continuously enter the filter bag 205 on the right side, the air permeability of the filter bag 205 decreases. This triggers the output shaft of the servo motor 201 to rotate again. The output shaft of the servo motor 201 drives the mounting bracket 202 and the rotating shaft 702 to rotate clockwise. The mounting bracket 202 drives the centrifuge tank 203 to move. The centrifuge tank 203 drives the swing plate 301 and friction ring 402 to move. The friction ring 402 continues to rotate under the action of the friction strip 401 on the left side, and the coil spring continues to store energy. Subsequently, the friction ring 402 passes over the friction strip 401 on the left side, and the coil spring releases energy, causing the centrifuge tank 203 to rotate at high speed. The centrifuge tank 203 drives the swing plate 301 and friction ring 402 to move at high speed. Under the action of centrifugal force, the swing plate 301 elastically contracts and rotates upwards. Inside the centrifuge tank 203... The drug granules are thrown out of the centrifuge barrel 203 under centrifugal force and dispersed in the granulation barrel 1 until the coil spring is completely released. The centrifuge barrel 203 stops rotating, the swing plate 301 elastically releases and rotates back to its original position, and the rotating shaft 702 drives the lever 703 to move. The lever 703 drives the sliding shaft 801 to slide along the guide groove 802. Under the action of the guide groove 802, the sliding shaft 801 gradually drives the lever 703 to extend out of the through groove of the rotating shaft 702. Then, the friction ring 402 contacts the friction strip 401 on the right side. Under the action of the friction strip 401 on the right side, the friction ring 402 drives the centrifuge barrel 203 to rotate. The coil spring is stressed and stores energy. At the same time, the lever 703 contacts and presses against the outer wall of the friction rod 704 on the right side. The friction rod 704 on the right side is stressed and elastically extends and slides to the left. The rotating frame 502 on the right rotates clockwise under the action of the friction rod 704, which in turn drives the four elastic sliding rods 503 on it to move. The elastic sliding rods 503 drive the vertical plate 504 to move, and the vertical plate 504 drives the four top rods 505 on it to move with the first wedge block 601. The first wedge block 601 is squeezed and elastically contracted and rotated by the nearest second wedge block 602. After passing the second wedge block 602, it elastically releases and rotates back to its original position. The first wedge block 601 continues to contact the remaining second wedge blocks 602 and repeats the above steps, so that when the rotating frame 502 rotates back to its original position, the top rods 505 will hit the filter bag 205 through the cooperation of the first wedge block 601 and the second wedge block 602. Then, the sliding shaft 801 drives the lever under the action of the guide groove 802. 703 gradually slides into the through groove of the rotating shaft 702 until the top axis of the centrifuge tank 203 coincides with the axis of the connecting pipe 204 on the right. At this time, the lever 703 passes over the friction rod 704 on the right, and the friction rod 704 is released from its restraint, elastically contracting and sliding back to its original position. The rotating frame 502 on the right rotates counterclockwise under the action of the friction rod 704, driving the four elastic sliding rods 503 on it to move. The elastic sliding rods 503 drive the vertical plate 504 to move, and the vertical plate 504 drives the four top rods 505 on it to move with the first wedge block 601. The first wedge block 601 is squeezed by the nearest second wedge block 602, and through the vertical plate 504, it drives the elastic sliding rods 503 to elastically extend and slide. At the same time, the vertical plate 504 drives the four top rods 505 on it to move away from the filter bag 205.Until the first wedge block 601 passes the nearest second wedge block 602, the first wedge block 601 is released from its restraint and moves. The elastic slide rod 503 rapidly contracts and slides, driving the four push rods 505 and the first wedge block 601 to move via the vertical plate 504. After the four push rods 505 move, they impact the outer wall of the filter bag 205, causing deformation and vibration of the outer wall of the filter bag 205. The medicine particles stuck in the gaps of the filter bag 205 fall off and fall into the centrifuge tank 203 through the connecting pipe 204. After the first wedge block 601 moves, it contacts the next second wedge block 602, and the above steps are repeated to achieve the same effect, until the friction rod 704 resets and the rotating frame 502 stops moving. This achieves the cleaning of the filter bag 205. Then, the servo motor 201 is controlled to move, and the above steps are repeated to achieve the same effect.

[0046] By cleaning the two filter bags 205 through the above steps, the granulator can work without stopping, while ensuring the filtration effect of the two filter bags 205 and preventing the filter bags 205 from becoming clogged and causing excessive pressure in the granulation tank 1.

[0047] A method for wet mixing and granulating a pharmaceutical product using the aforementioned wet mixing and granulating machine includes the following steps:

[0048] S1: The servo motor 201 controls the mounting bracket 202 to drive the centrifuge barrel 203 to move, so that the top axis of the centrifuge barrel 203 coincides with the axis of the connecting pipe 204. The swing plate 301 blocks the airflow, causing the medicine particles in the filter bag 205 to fall.

[0049] S2: The spring stores energy through the cooperation of friction strip 401 and friction ring 402. When friction ring 402 passes over friction strip 401, centrifuge barrel 203 rotates at high speed to throw out the medicine particles.

[0050] S3: Through the cooperation of the first wedge block 601 and the second wedge block 602, the elastic slide bar 503 quickly and elastically contracts and slides, causing the medicine particles stuck in the gap of the filter bag 205 to fall off.

[0051] Those skilled in the art should understand that the above embodiments do not limit the present invention in any way, and all technical solutions obtained by equivalent substitution or equivalent transformation fall within the protection scope of the present invention.

Claims

1. A wet mixing granulator for a pharmaceutical product, comprising a granulation chamber (1), characterized in that: It also includes a bulk material mechanism, which includes a servo motor (201) installed on the pelleting barrel (1). The output shaft of the servo motor (201) rotates through the pelleting barrel (1) and is fixedly installed with a mounting frame (202). A centrifuge barrel (203) is rotatably installed inside the mounting frame (202). A coil spring is provided between the centrifuge barrel (203) and the mounting frame (202). A connecting pipe (204) is symmetrically connected to the pelleting barrel (1). A filter bag (205) is connected to the connecting pipe (204) and an impact mechanism is provided. The bulk material handling mechanism also includes a swing plate (301) that is elastically hinged inside the centrifuge drum (203); The bulk material mechanism also includes friction strips (401) symmetrically fixedly installed inside the pelleting barrel (1), and a friction ring (402) that cooperates with the friction strips (401) is fixedly sleeved on the centrifuge barrel (203). The impact mechanism includes two brackets (501) fixedly installed on the granulation barrel (1), a filter bag (205) fixedly installed on the brackets (501), a rotating frame (502) rotatably sleeved on the outer wall of the connecting pipe (204), a number of elastic sliding rods (503) elastically sliding on the rotating frame (502) in the horizontal direction, a vertical plate (504) fixedly installed at the end of each of the elastic sliding rods (503), and a number of top rods (505) that cooperate with the filter bag (205) fixedly installed on the vertical plate (504). The impact mechanism also includes a first wedge block (601) that is elastically hinged to one side of the vertical plate (504), and a number of second wedge blocks (602) are fixedly installed on the outer wall of the connecting pipe (204). The first wedge block (601) cooperates with the number of second wedge blocks (602). The impact mechanism also includes a C-shaped frame (701) fixedly installed on the pelletizing barrel (1). A rotating shaft (702) driven by a servo motor (201) is rotatably installed inside the C-shaped frame (701). A through groove is provided on the rotating shaft (702). A lever (703) is slidably installed in the through groove. A friction rod (704) is elastically slidably installed on the bracket (501). The friction rod (704) cooperates with the rotating frame (502) and the lever (703). A sliding shaft (801) is fixedly installed at the bottom of the lever (703), and a guide groove (802) is provided on the shaped frame (701), with the sliding shaft (801) located in the guide groove (802).

2. The wet mixing granulation machine for a pharmaceutical product according to claim 1, characterized in that: The guide groove (802) is elliptical.

3. The wet mixing granulation machine for a pharmaceutical product according to claim 2, characterized in that: The sliding shaft (801) cooperates with the guide groove (802) to make the lever (703) reciprocate along the through groove of the rotating shaft (702).

4. A method for wet mixing and granulating a pharmaceutical product, using the wet mixing and granulating machine of claim 3, characterized in that, The method includes the following steps: S1: The servo motor (201) controls the mounting bracket (202) to drive the centrifuge barrel (203) to move, so that the top axis of the centrifuge barrel (203) coincides with the axis of the connecting pipe (204), and the swing plate (301) blocks the airflow, causing the drug particles in the filter bag (205) to fall. S2: The coil spring stores energy through the cooperation of the friction strip (401) and the friction ring (402). When the friction ring (402) passes over the friction strip (401), the centrifuge barrel (203) rotates at high speed to throw out the drug particles. S3: Through the cooperation of the first wedge block (601) and the second wedge block (602), the elastic slide bar (503) is rapidly and elastically contracted and slid, causing the drug particles stuck in the gap of the filter bag (205) to fall off.

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