Traditional Chinese medicine combined pill for treating thrombus and carotid plaque and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine combined pill for treating thrombus and carotid plaque and a preparation method, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine combined pill is composed of a monarch drug, a ministerial drug, an adjuvant drug and a conductant drug in parts by weight, the monarch drug comprises safflower, ligusticum wallichii and the like, the ministerial drug comprises notopterygium root, rhizoma atractylodis and the like, the adjuvant drug comprises radix paeoniae alba, radix puerariae and the like, and the conductant drug is ginkgo leaf. The preparation method comprises the following steps: weighing the medicinal materials, cleaning and airing, crushing and sieving, mixing and briquetting, and pelleting and drying. The pill follows the syndrome differentiation and treatment and holism concept of traditional Chinese medicine, the cure and rehabilitation rate reaches about 98% by reducing phlegm, clearing damp, promoting blood circulation, removing blood stasis, softening hardness, dissipating binds, activating meridians to stop pain and conditioning viscera to improve qi and blood circulation after being taken for 1-3 months, aspirin and statins medicines and operations can be replaced, side effects and operation risks are avoided, the clinical medicine vacancy is filled, and the pill is worthy of popularization and application. The medicine is suitable for treating thrombus, carotid plaque and related symptoms.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine combination pills, specifically to traditional Chinese medicine combination pills for the treatment of thrombosis and carotid artery plaques, and their preparation methods. Background Technology

[0002] Currently, clinical treatment options for thrombosis and carotid artery plaques are relatively limited, mainly relying on medication and surgical intervention. Medication treatment often uses enteric-coated aspirin and statins (such as atorvastatin calcium tablets). These drugs can only inhibit platelet aggregation, regulate blood lipids, and relieve symptoms; they cannot fundamentally eliminate thrombi and plaques. Furthermore, long-term use can easily cause side effects such as gastrointestinal irritation, liver and kidney damage, and bleeding tendencies. Surgical treatments (such as carotid endarterectomy and stent implantation) can directly address the lesions, but they have drawbacks including high surgical risks, numerous postoperative complications, and limited applicability (e.g., elderly patients or those with underlying diseases may have difficulty tolerating them).

[0003] Furthermore, existing treatment plans lack consideration for individual patient differences, making it difficult to achieve individualized treatment based on different syndrome types (such as phlegm-dampness stagnation, qi stagnation and blood stasis, and liver and kidney yin deficiency). Moreover, there is no Chinese medicine combination plan that can simultaneously "dissipate lesions, regulate the internal organs, and improve qi and blood circulation," resulting in gaps in clinical treatment that are "treating the symptoms but not the root cause" and "difficult to balance safety and effectiveness." There is an urgent need for safe, effective, and root-cause treatment solutions for thrombosis and carotid artery plaques to make up for the shortcomings of existing treatment methods. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to overcome the defects of the above-mentioned technology and provide a combination pill of traditional Chinese medicine for the treatment of thrombosis and carotid artery plaque and its preparation method.

[0005] To solve the above-mentioned technical problems, the present invention provides a traditional Chinese medicine combination pill for treating thrombosis and carotid artery plaque and a preparation method thereof: the traditional Chinese medicine combination pill for treating thrombosis and carotid artery plaque is composed of principal drug, assistant drug, adjuvant drug and guiding drug by weight.

[0006] The principal herbs include 5-20 parts of safflower, 10-20 parts of chuanxiong rhizome, 5-20 parts of salvia miltiorrhiza root, 1-15 parts of peach kernel, 2-10 parts of myrrh, 2-20 parts of vaccaria seed, 5-25 parts of prunella vulgaris root, 1-10 parts of earthworm, and 5-15 parts of scorpion.

[0007] The herbal ingredients include 5-20 parts of Notopterygium incisum, 10-25 parts of Atractylodes lancea, 5-15 parts of Pinellia ternata, 10-30 parts of Phellodendron chinense, and 5-15 parts of Crataegus pinnatifida.

[0008] The adjuvant herbs include 5-25 parts of white peony root, 1-20 parts of kudzu root, and 2-15 parts of poria cocos.

[0009] The medicine includes 5-35 parts of ginkgo leaves.

[0010] As an improvement, the weight parts of the principal herbs are 8-15 parts of safflower, 12-18 parts of chuanxiong rhizome, 8-15 parts of danshen rhizome, 3-12 parts of peach kernel, 4-8 parts of myrrh, 5-15 parts of vaccaria seed, 8-20 parts of prunella vulgaris, 3-8 parts of earthworm, and 8-12 parts of scorpion.

[0011] As an improvement, the weight parts of the following herbs are as follows: 8-15 parts of Notopterygium root, 12-20 parts of Atractylodes rhizome, 8-12 parts of Pinellia tuber, 15-25 parts of Phellodendron bark, and 8-12 parts of Crataegus pinnatifida.

[0012] As an improvement, the weight parts of the adjuvant herbs are 8-20 parts of white peony root, 5-15 parts of kudzu root, and 5-12 parts of poria cocos.

[0013] As an improvement, the weight of ginkgo leaves in the medicine is 10-30 parts.

[0014] A method for preparing a traditional Chinese medicine combination pill for treating thrombosis and carotid artery plaques, the preparation method comprising the following steps:

[0015] Step 1: Weigh out the medicinal materials of the principal drug, assistant drug, adjuvant drug and guiding drug according to the weight proportions of the traditional Chinese medicine combination pill for treating thrombosis and carotid artery plaque as described in any one of claims 1-5.

[0016] Step 2: Wash each of the herbs weighed in Step 1 (principal, assistant, adjuvant, and guiding herbs) separately to remove impurities, and then place them in a ventilated place to dry.

[0017] Step 3: Grind each of the herbs in the principal, assistant, adjuvant, and guiding herbs that were dried in Step 2 into fine powder and pass them through an 80-120 mesh sieve to obtain fine powder of each herb.

[0018] Step 4: Mix the fine powders of the principal herbs, assistant herbs, adjuvant herbs, and medicant herbs obtained in Step 3 evenly to obtain a mixed medicinal powder.

[0019] Step 5: Add refined honey to the mixed medicinal powder obtained in Step 4. The mass of the refined honey is 1-1.5 times the mass of the mixed medicinal powder. Stir until a uniform medicinal mass is formed.

[0020] Step Six: The medicated powder obtained in Step Five is made into pills with a diameter of 3-5mm, and then placed in an oven at 40-50℃ to dry for 2-4 hours, thus obtaining a combination of traditional Chinese medicine pills for the treatment of thrombosis and carotid artery plaques.

[0021] As an improvement, the pulverization in step three is carried out using a traditional Chinese medicine pulverizer with a rotation speed of 2000-3000 r / min and a pulverization time of 10-20 minutes.

[0022] As an improvement, the honey refined in step five is of medium quality, with a water content of 14%-16% and a relative density of 1.37-1.38.

[0023] As an improvement, the drying in step six is ​​carried out using a vacuum oven with a vacuum degree of -0.08 to -0.06 MPa.

[0024] The advantages of this invention compared to existing technologies are as follows: First, it offers outstanding and fundamental therapeutic effects. Through a comprehensive approach that addresses the root cause of phlegm and dampness, invigorates blood circulation, removes blood stasis, softens and disperses masses, it directly promotes thrombus dissolution and the elimination of carotid artery plaques. The cure rate reaches approximately 98% after 1-3 months of treatment, fundamentally improving vascular blockage, reducing the risk of myocardial infarction and stroke, and solving the problem of existing treatments that only treat the symptoms, not the root cause. Second, it boasts high safety. Using traditional Chinese medicine as raw material replaces aspirin and statins, avoiding side effects such as gastrointestinal irritation and liver and kidney damage. It eliminates the need for surgery, thus avoiding surgical trauma and postoperative complications, and is suitable for a wider range of patients. Third, it adheres to the principle of syndrome differentiation and treatment, adjusting the weight and proportion of medicinal materials according to different syndrome types such as phlegm-dampness obstruction and qi stagnation and blood stasis, achieving individualized treatment that adapts to individual patient differences and enhances the targeted nature of the treatment. Fourth, it takes into account overall conditioning, regulating the functions of internal organs and improving the circulation of qi and blood through medicinal materials, optimizing the internal environment, and reducing the generation of pathological factors. This ensures both immediate efficacy and prevention of recurrence, achieving a "treat both the symptoms and the root cause." Fifth, the preparation process is stable, and standardized steps ensure the retention and distribution of effective ingredients, making it suitable for industrial production. The pill dosage form has a long-lasting effect, is convenient to take, and helps patients cooperate with the treatment course, ensuring stable efficacy. Attached Figure Description

[0025] Figure 1 This is a schematic diagram of the traditional Chinese medicine combination pills used in this invention for the treatment of thrombosis and carotid artery plaques.

[0026] Figure 2 This is a schematic diagram illustrating the preparation method of the traditional Chinese medicine combination pills used in the present invention for treating thrombosis and carotid artery plaques. Detailed Implementation

[0027] To facilitate understanding of this application, a more complete description will be provided below with reference to the accompanying drawings, which illustrate embodiments of the present application. However, the present application can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that the disclosure of this application will be thorough and complete.

[0028] Referring to the accompanying drawings, a traditional Chinese medicine combination pill for treating thrombosis and carotid artery plaques and its preparation method are described. The traditional Chinese medicine combination pill for treating thrombosis and carotid artery plaques is composed of principal drug, assistant drug, adjuvant drug and guiding drug by weight.

[0029] The principal herbs include 5-20 parts of safflower, 10-20 parts of chuanxiong rhizome, 5-20 parts of salvia miltiorrhiza root, 1-15 parts of peach kernel, 2-10 parts of myrrh, 2-20 parts of vaccaria seed, 5-25 parts of prunella vulgaris root, 1-10 parts of earthworm, and 5-15 parts of scorpion.

[0030] The herbal ingredients include 5-20 parts of Notopterygium incisum, 10-25 parts of Atractylodes lancea, 5-15 parts of Pinellia ternata, 10-30 parts of Phellodendron chinense, and 5-15 parts of Crataegus pinnatifida.

[0031] The adjuvant herbs include 5-25 parts of white peony root, 1-20 parts of kudzu root, and 2-15 parts of poria cocos.

[0032] The medicine includes 5-35 parts of ginkgo leaves.

[0033] The principal ingredients consist of 8-15 parts by weight of safflower, 12-18 parts by weight of chuanxiong rhizome, 8-15 parts by weight of danshen rhizome, 3-12 parts by weight of peach kernel, 4-8 parts by weight of myrrh, 5-15 parts by weight of vaccaria seed, 8-20 parts by weight of prunella vulgaris, 3-8 parts by weight of earthworm, and 8-12 parts by weight of scorpion.

[0034] The weight parts of the following herbs are as follows: Notopterygium root 8-15 parts, Atractylodes lancea root 12-20 parts, Pinellia ternata root 8-12 parts, Phellodendron chinense bark 15-25 parts, and Crataegus pinnatifida fruit 8-12 parts.

[0035] The weight parts of the adjuvant herbs are 8-20 parts of white peony root, 5-15 parts of kudzu root, and 5-12 parts of poria cocos.

[0036] The weight of ginkgo leaves in the medicine is 10-30 parts.

[0037] A method for preparing a traditional Chinese medicine combination pill for treating thrombosis and carotid artery plaques, the preparation method comprising the following steps:

[0038] Step 1: Weigh out the medicinal materials of the principal drug, assistant drug, adjuvant drug and guiding drug according to the weight proportions of the traditional Chinese medicine combination pill for treating thrombosis and carotid artery plaque as described in any one of claims 1-5.

[0039] Step 2: Wash each of the herbs weighed in Step 1 (principal, assistant, adjuvant, and guiding herbs) separately to remove impurities, and then place them in a ventilated place to dry.

[0040] Step 3: Grind each of the herbs in the principal, assistant, adjuvant, and guiding herbs that were dried in Step 2 into fine powder and pass them through an 80-120 mesh sieve to obtain fine powder of each herb.

[0041] Step 4: Mix the fine powders of the principal herbs, assistant herbs, adjuvant herbs, and medicant herbs obtained in Step 3 evenly to obtain a mixed medicinal powder.

[0042] Step 5: Add refined honey to the mixed medicinal powder obtained in Step 4. The mass of the refined honey is 1-1.5 times the mass of the mixed medicinal powder. Stir until a uniform medicinal mass is formed.

[0043] Step Six: The medicated powder obtained in Step Five is made into pills with a diameter of 3-5mm, and then placed in an oven at 40-50℃ to dry for 2-4 hours, thus obtaining a combination of traditional Chinese medicine pills for the treatment of thrombosis and carotid artery plaques.

[0044] The pulverization in step three is carried out using a traditional Chinese medicine pulverizer with a rotation speed of 2000-3000 r / min and a pulverization time of 10-20 minutes.

[0045] The honey refined in step five is of medium quality, with a water content of 14%-16% and a relative density of 1.37-1.38.

[0046] The drying process described in step six is ​​carried out using a vacuum oven with a vacuum degree of -0.08 to -0.06 MPa.

[0047] Principal drug:

[0048] Safflower: Functions and effects: It can promote blood circulation, relieve pain, clear stagnant blood in blood vessels, promote thrombus dissolution, improve blood vessel blockage caused by blood stasis, and reduce the risk of myocardial infarction and stroke.

[0049] Preparation method: Take the raw medicinal material, remove impurities and calyxes, select complete petals, and place them in a clean container for later use.

[0050] Purpose of processing: to remove impurities, ensure the purity of medicinal materials, avoid impurities affecting efficacy, and at the same time make the texture of medicinal materials uniform, which is convenient for subsequent pulverization and dissolution of active ingredients.

[0051] Chuanxiong: Functions and effects: It can invigorate blood circulation, dispel wind and relieve pain. It can both invigorate blood circulation and remove blood stasis to dredge blood vessels, and promote the circulation of qi and blood to relieve neck pain and headache caused by qi and blood stagnation, while improving symptoms of insufficient blood supply to the brain.

[0052] Processing method: Take the raw medicinal material, remove the fibrous roots and impurities, wash it thoroughly, moisten it, cut it into thin slices, place it in a ventilated and dry place to air dry, and sift out the debris.

[0053] Purpose of processing: Slicing increases the contact area between the medicinal material and the solvent, which is beneficial for the extraction of active ingredients; air drying avoids the destruction of volatile components in the medicinal material by high temperature, thus ensuring its qi-regulating and pain-relieving effects.

[0054] Danshen: Functions and effects: promotes blood circulation and removes blood stasis, regulates menstruation and relieves pain, clears the heart and relieves irritability. It can clear blood stasis in blood vessels, improve the condition of blood vessel walls, delay the progression of arteriosclerosis, and relieve discomfort such as chest tightness and irritability caused by blood stasis.

[0055] Processing method: Take the raw medicinal material, remove impurities and residual stems, wash it thoroughly, moisten it, cut it into thick slices, and sun-dry or dry it at low temperature (temperature not exceeding 60℃).

[0056] Purpose of processing: The thick slices facilitate subsequent pulverization; low-temperature drying can retain the effective components in the medicinal materials, avoid degradation caused by high temperature, and ensure the stability of the blood-activating and stasis-removing effects.

[0057] Peach kernel: Functions and effects: It can promote blood circulation and remove blood stasis, moisten the intestines and promote bowel movements. It can deeply dissipate deep blood stasis in blood vessels, promote the decomposition of thrombi, and at the same time, it can remove metabolic waste from the body through the effect of moistening the intestines and promoting bowel movements, thus reducing adverse stimulation to blood vessels.

[0058] Preparation method: Take the raw medicinal material, remove impurities, put it into boiling water and boil until the outer skin is slightly wrinkled, take it out and quickly soak it in cold water, peel off the seed coat, and dry it in the sun; if you need to enhance the blood-activating effect, you can mix the peeled peach kernels with yellow rice wine, let them soak until the wine is absorbed, put them in a stir-frying container, stir-fry them over low heat until the surface is slightly yellow, take them out and let them cool.

[0059] Purpose of processing: Removing the skin can remove ineffective components from the seed coat and reduce interference with the efficacy of the medicine; processing with wine can enhance the blood-activating and meridian-clearing effects of peach kernels, making them more suitable for the treatment of thrombosis and carotid artery plaques.

[0060] Myrrh: Functions and effects: It can disperse blood stasis, relieve pain, reduce swelling and promote tissue regeneration. It can dissipate blood stasis in blood vessels, relieve pain caused by blood stasis, and promote the repair of damaged blood vessel walls and reduce vascular inflammation.

[0061] Processing method: Take the raw medicinal material, remove impurities, break it into small pieces, place it in a stir-frying container, stir-fry over low heat until the surface melts and the color deepens, take it out and let it cool, then grind it into fine particles.

[0062] Purpose of processing: Stir-frying can reduce the irritation of myrrh and reduce its impact on the gastrointestinal tract; crushing and pulverizing can increase the specific surface area of ​​the medicinal material, which is conducive to the dissolution of active ingredients and enhances the effects of dispersing blood stasis and relieving pain.

[0063] Wang Bu Liu Xing: Functions and effects: promotes blood circulation and menstruation, promotes lactation and reduces swelling, promotes urination and relieves strangury. It can clear blood vessels and promote the excretion of thrombi. At the same time, through its diuretic effect, it can accelerate the excretion of excess water and metabolic waste from the body and reduce the burden on blood vessels.

[0064] Processing method: Take the raw medicinal material, remove impurities, place it in a stir-frying container, stir-fry over low heat until the surface puffs up, the color deepens, and there is a popping sound. After taking it out, let it cool, and then sift to remove the debris.

[0065] Purpose of processing: Stir-frying makes the medicinal materials brittle and easy to crush, and it can also change the physicochemical properties of the medicinal materials, enhance their blood-activating and menstruation-regulating effects, and improve their ability to dissolve and expel thrombi.

[0066] Prunella vulgaris: Functions and effects: Clears liver fire, improves eyesight, disperses nodules and reduces swelling. It can clear liver fire in the body, reduce the damage of liver fire to blood vessels, soften carotid artery plaques, promote plaque dissipation, and relieve insufficient blood supply to the brain caused by plaques compressing blood vessels.

[0067] Preparation method: Take the raw medicinal material, remove impurities and residual stems, wash it, dry it in the sun, and cut it into sections (1-2cm in length).

[0068] Purpose of processing: Cutting into sections makes the medicinal materials more regular in shape, which is convenient for subsequent mixing and extraction; sun drying ensures that the medicinal materials are dry, prevents mold, prolongs storage time, and at the same time retains their effective components for dispersing nodules and reducing swelling.

[0069] Earthworm: Functions and effects: Clears heat and calms the nerves, unblocks the meridians, relieves asthma, and promotes urination. It can clear stagnation in the meridians, promote blood circulation, soften thrombi and plaques, relieve muscle stiffness and movement disorders caused by blocked meridians, and improve the body's water metabolism through diuresis.

[0070] Preparation method: Take the raw medicinal material, remove impurities, wash it, cut it into sections, and sun-dry it. If you need to enhance the effect of clearing the meridians, you can mix the earthworm sections with rice wine, let it soak until the wine is absorbed, place it in a stir-frying container, stir-fry it over low heat until the surface is slightly charred, and then take it out to cool.

[0071] Purpose of processing: Cutting into sections facilitates pulverization and extraction of active ingredients; processing with alcohol can enhance the earthworm's ability to unblock meridians, making it more suitable for symptoms of meridian blockage caused by thrombosis and carotid artery plaques, while reducing its cold nature and minimizing irritation to the spleen and stomach.

[0072] Whole scorpion: Functions and effects: relieves wind and spasms, unblocks meridians and relieves pain, detoxifies and dissipates nodules. It can deeply dredge the meridians, relieve severe pain caused by meridian obstruction, soften and dissipate carotid artery plaques, improve vascular patency, and reduce the risk of cerebral infarction and stroke caused by plaque detachment.

[0073] Preparation method: Take the raw medicinal material, remove impurities, feet and whiskers, wash and dry in the sun; or take clean whole scorpions, add salt water and mix well, let it soak until the salt is absorbed, place it in a stir-frying container, stir-fry over low heat until the surface is slightly yellow, take it out and let it cool (use 2 kg of salt for every 100 kg of whole scorpions).

[0074] Purpose of processing: Removing the feet and whiskers can reduce ineffective components and ensure the purity of the medicinal material; salt processing can guide the medicine to the kidneys, enhance its effects of clearing the meridians, relieving pain, dispersing nodules and reducing swelling, while reducing the toxicity of the whole scorpion and improving the safety of medication.

[0075] Minister's Medicine:

[0076] Notopterygium root: Functions and effects: It can relieve exterior syndromes and dispel cold, dispel wind and dampness, and relieve pain. It can dispel wind and dampness in the body, relieve neck pain and muscle stiffness caused by wind and dampness obstructing the meridians, and improve symptoms of limited neck movement.

[0077] Processing method: Take the raw medicinal material, remove impurities and residual stems, wash it thoroughly, soak it, slice it thinly, and sun-dry or dry it at low temperature.

[0078] Purpose of processing: Slicing increases the contact area of ​​the medicinal material, which is conducive to the dissolution of active ingredients; low-temperature drying can retain the volatile components in Qianghuo, ensuring its effects of dispelling wind and dampness and relieving pain.

[0079] Atractylodes lancea: Functions and effects: It dries dampness and strengthens the spleen, dispels wind and cold, and improves eyesight. It can clear away phlegm and dampness in the body, reduce the "pathological basis" of phlegm and dampness accumulating in blood vessels to form plaques, and at the same time strengthen the spleen to enhance the ability to metabolize water and dampness, and improve the blood and qi stagnation caused by phlegm and dampness obstruction.

[0080] Processing method: Take the raw medicinal material, remove impurities and fibrous roots, wash it clean and moisten it thoroughly, cut it into thick slices, and sun-dry it. If it is necessary to enhance the drying effect, the slices of Atractylodes lancea can be placed in a stir-frying container, mixed with rice water, and left to soak until the rice water is absorbed. Stir-fry over low heat until the surface is slightly yellow, then take it out and let it cool (use 10-15 kg of rice water for every 100 kg of Atractylodes lancea).

[0081] Purpose of processing: Processing with rice water can reduce the dryness of Atractylodes lancea, reduce damage to the spleen and stomach, and enhance its effects of drying dampness and strengthening the spleen, making it more suitable for the treatment needs of patients with phlegm-dampness retention type thrombosis and carotid artery plaque.

[0082] Pinellia: Functions and effects: It dries dampness and resolves phlegm, relieves nausea and vomiting, eliminates lumps and dissipates nodules. It can clear excess phlegm and dampness in the body, reduce the possibility of phlegm and dampness combining with blood stasis to form plaques, and at the same time relieve symptoms such as dizziness and nausea caused by phlegm and dampness disturbing the upper body.

[0083] Processing method: Take the raw medicinal material, remove impurities, wash it and soak it until there is no dry core inside. Take it out and slice it, mix it with alum water, let it soak until the alum water is absorbed, put it in a stir-frying container, stir-fry it over low heat until the surface is slightly yellow, take it out and let it cool (use 5-10 kg of alum per 100 kg of Pinellia ternata), and that is the processed Pinellia ternata.

[0084] Purpose of processing: Raw Pinellia ternata is toxic. Processing with alum can reduce its toxicity and improve the safety of medication; at the same time, it can enhance its effects of drying dampness and resolving phlegm, reduce irritation to the gastrointestinal tract, and make it more suitable for long-term use.

[0085] Phellodendron bark: Functions and effects: Clears heat and dries dampness, drains fire and detoxifies. It can eliminate damp-heat evil formed by the long-term stagnation of phlegm and dampness in the body, reduce vascular inflammation, delay the progression of arteriosclerosis, and improve symptoms such as difficulty in urination caused by damp-heat.

[0086] Preparation method: Take the raw medicinal material, remove impurities, wash and soak thoroughly, cut into thin slices, and sun dry; if it is necessary to enhance the yin-nourishing and fire-reducing effects, mix the Phellodendron bark slices with salt water, let them soak until the salt is absorbed, place them in a frying container, and fry over low heat until the surface is slightly charred, then remove and let cool (use 2 kg of salt for every 100 kg of Phellodendron bark).

[0087] Purpose of processing: Slicing facilitates the extraction of active ingredients; salt processing can guide the medicine to the kidneys, enhancing its effects of clearing heat and drying dampness, purging fire and detoxifying, while reducing the cold nature of Phellodendron bark and minimizing damage to the spleen and stomach yang qi.

[0088] Hawthorn; Functions: It can promote digestion and eliminate food stagnation, and promote blood circulation. It can promote the digestion and absorption of food, reduce the obstruction of qi and blood circulation by food stagnation, and at the same time promote blood circulation to help dissipate thrombi and plaques, and relieve abdominal distension and pain caused by blood stasis.

[0089] Preparation method: Take the raw medicinal material, remove impurities and pits, wash and slice, and sun-dry. If it is necessary to enhance the blood-activating and stasis-removing effect, the hawthorn slices can be placed in a stir-frying container and stir-fried over low heat until the surface is dark brown and the inside is yellowish-brown. Remove and let cool to make charred hawthorn.

[0090] Purpose of processing: Removing the pits removes ineffective components and ensures the purity of the medicinal material; stir-frying enhances the blood-activating and stasis-removing effects of hawthorn, while reducing its acidity and irritation to the teeth and gastrointestinal tract, making it easier to take for a long time.

[0091] Adjuvant:

[0092] White peony root: Functions and effects: Nourishes blood and regulates menstruation, astringes yin and stops sweating, softens the liver and relieves pain, and calms liver yang. It can replenish blood in the body, improve blood deficiency symptoms caused by blood stasis, soften the liver to stabilize the liver's function of dispersing and draining, ensure smooth flow of qi and blood, and relieve headaches and dizziness caused by hyperactivity of liver yang.

[0093] Preparation method: Take the raw medicinal material, remove impurities and fibrous roots, wash it thoroughly, moisten it, slice it thinly, and sun-dry it. If you need to enhance the blood-nourishing and liver-soothing effects, you can mix the white peony slices with rice wine, let it soak until the wine is absorbed, place it in a stir-frying container, stir-fry it over low heat until the surface is slightly yellow, take it out and let it cool (use 10-15 kg of rice wine for every 100 kg of white peony), that is, wine-processed white peony.

[0094] Purpose of processing: Slicing facilitates the extraction of active ingredients; processing with wine can enhance the blood-nourishing and liver-soothing effects of white peony, making it more suitable for patients with thrombosis and carotid artery plaques who suffer from symptoms caused by blood stasis and blood deficiency, while reducing its cold nature and minimizing stimulation to the spleen and stomach.

[0095] Kudzu root: Functions and effects: relieves muscle tension and fever, promotes body fluid production and quenches thirst, promotes rash eruption, raises yang and stops diarrhea, unblocks meridians and collaterals, detoxifies alcohol. It can dredge meridians, promote blood circulation, improve dizziness and fatigue caused by insufficient blood supply to the brain, and at the same time raise yang to enhance spleen and stomach function, promote water and dampness metabolism, and reduce phlegm and dampness production.

[0096] Processing method: Take the raw medicinal material, remove impurities, wash it thoroughly, moisten it, cut it into thick slices, and sun-dry or dry it at low temperature.

[0097] Purpose of processing: The thick slices facilitate subsequent crushing and extraction; low-temperature drying can preserve the effective components in kudzu root, avoid degradation caused by high temperature, and ensure its effects of promoting blood circulation and improving cerebral blood supply.

[0098] Poria cocos: Functions and effects: It promotes diuresis and eliminates dampness, strengthens the spleen and calms the mind. It can promote the excretion of excess water in the body, reduce the generation of phlegm and dampness, strengthen the spleen to enhance the spleen and stomach's digestive function, improve the retention of dampness caused by spleen and stomach weakness, provide a good foundation for the generation of qi and blood, and help improve the circulation of qi and blood.

[0099] Processing method: Take the raw medicinal material, remove impurities, wash it thoroughly, moisten it, cut it into cubes or thin slices, and sun-dry it.

[0100] Purpose of processing: Cutting into pieces or slices increases the contact area of ​​the medicinal materials, which is conducive to the dissolution of active ingredients; sun drying can ensure that the medicinal materials are dry, prevent mold, extend the storage time, and at the same time retain their effects of promoting diuresis and removing dampness, strengthening the spleen and calming the mind.

[0101] Used medicine:

[0102] Ginkgo biloba leaves: Functions and effects: promote blood circulation and remove blood stasis, clear the meridians and relieve pain, astringe the lungs and relieve asthma, clear turbidity and lower lipids. They can unclog blood vessels, promote thrombus dissolution, improve the elasticity of blood vessel walls, lower blood lipid levels, reduce lipid deposition on blood vessel walls, delay the progression of arteriosclerosis, and relieve chest tightness and chest pain caused by blood stasis.

[0103] Preparation method: Take ginkgo leaves harvested in autumn, remove impurities and broken branches, wash them, dry them in the sun, and grind them into coarse powder (pass through a 20-mesh sieve).

[0104] Purpose of processing: Sun drying ensures that the ginkgo leaves are dry and prevents the oxidation of active ingredients; the coarse powder form facilitates subsequent mixing and pulverization with other medicinal materials, and also helps the active ingredients to be evenly distributed during the preparation of pills, ensuring stable efficacy.

[0105] Application of Holistic Concept and Dialectical Treatment

[0106] Holistic Approach: The herbal combination pills described in this invention adhere to the holistic concept of Traditional Chinese Medicine (TCM), which views thrombosis and carotid artery plaques as not isolated local vascular lesions, but rather as local manifestations of systemic qi and blood circulation disorders and organ dysfunction. Therefore, the treatment process not only targets the local lesions of thrombosis and plaques but also addresses the overall regulation of organ function and improvement of qi and blood circulation.

[0107] At the level of internal organs, Atractylodes lancea and Poria cocos are used to strengthen the spleen and remove dampness, thereby improving the spleen's function of transporting and transforming water and dampness and reducing the generation of phlegm and dampness. Paeonia lactiflora is used to soothe the liver and stabilize the liver's function of regulating qi and blood. The synergistic treatment of multiple internal organs improves the internal environment that leads to the formation of thrombi and plaques from the root.

[0108] From the perspective of Qi and blood, the principal drug invigorates blood circulation, removes blood stasis, softens hard masses and dissipates nodules; the assistant drug helps to resolve phlegm and dampness, unblock the meridians and relieve pain; the adjuvant drug nourishes blood, softens the liver and strengthens the spleen; and the guiding drug unblocks the meridians and lowers lipids. It regulates the flow of Qi and blood in multiple dimensions, which not only dissipates existing thrombi and plaques, but also improves the generation and circulation of Qi and blood, and prevents the recurrence of the disease.

[0109] Application of syndrome differentiation and treatment:

[0110] This invention is based on the TCM principle of "syndrome differentiation and treatment," and adjusts the weight proportions of each medicinal material according to different syndrome types in patients with thrombosis and carotid artery plaques to achieve individualized treatment. The specific syndrome types and medication adjustments are as follows:

[0111] Phlegm-dampness stagnation type:

[0112] Symptoms: Patients often experience dizziness, heaviness in the head, chest tightness, heaviness in the limbs, white and greasy tongue coating, and slippery pulse. Carotid artery plaques are often soft in texture, and thrombosis is closely related to phlegm and dampness obstruction.

[0113] Medication adjustments: Increase the weight of Atractylodes lancea, Pinellia ternata, and Phellodendron chinense in the assistant herbs (Atractylodes lancea 18-25 parts, Pinellia ternata 12-15 parts, Phellodendron chinense 20-30 parts) to enhance the expectorant and dampness-removing effects; appropriately increase the weight of Prunella vulgaris in the principal herb (20-25 parts) to enhance the softening and dissipating effects and accelerate the dissipation of plaques.

[0114] Qi stagnation and blood stasis type:

[0115] Symptoms: Patients often experience fixed neck pain, stabbing headache, depression, dark purple tongue or ecchymosis, and choppy pulse. Thrombosis is closely related to blood stasis, and carotid artery plaques are often hard in texture.

[0116] Medication adjustments: Increase the weight of safflower, chuanxiong, and peach kernel in the principal herbs (safflower 15-20 parts, chuanxiong 18-20 parts, peach kernel 12-15 parts) to enhance the blood-activating and stasis-removing effects; appropriately increase the weight of notopterygium in the assistant herbs (15-20 parts) to enhance the meridian-clearing and pain-relieving effects and alleviate pain symptoms.

[0117] Liver and Kidney Yin Deficiency

[0118] Symptoms: Patients often experience dizziness, tinnitus, lower back and knee weakness, insomnia, dreaminess, hot palms and soles, thin tongue coating, and thready and rapid pulse. Thrombosis and plaque formation are related to poor blood circulation caused by liver and kidney yin deficiency.

[0119] Medication adjustments: Increase the weight of white peony root and kudzu root in the adjuvant herbs (20-25 parts white peony root and 15-20 parts kudzu root) to enhance the effects of nourishing blood, softening the liver, promoting body fluid production, and unblocking the meridians; appropriately reduce the weight of phellodendron bark in the assistant herbs (10-15 parts) to reduce its cold nature and avoid damaging yin fluids.

[0120] Pharmacological analysis:

[0121] The effective components of the various medicinal materials in the Chinese herbal combination pills described in this invention work synergistically to produce therapeutic effects on thrombosis and carotid artery plaques from multiple target sites. The specific pharmacological mechanism is as follows:

[0122] Antithrombotic and thrombolytic effects:

[0123] The main ingredients in the herb, such as safflower yellow pigment, ligustrazine, and tanshinone IIA, can inhibit platelet aggregation, reduce platelet adhesion rate, and decrease the "raw materials" for thrombus formation. At the same time, these ingredients can activate plasminogen, promote plasmin production, enhance the activity of the fibrinolytic system, accelerate the dissolution of existing thrombi, and improve vascular patency.

[0124] Peach kernels contain amygdalin, and Wangbuliuxing contains saponins, which can dilate blood vessels, reduce vascular resistance, improve blood rheological parameters, reduce blood stasis, and help inhibit thrombus formation and promote thrombus dissolution.

[0125] Inhibits carotid plaque formation and promotes plaque dissipation:

[0126] The principal ingredient, Prunella vulgaris, contains prunella glycosides, earthworm contains lumbrokinase, and scorpion venom polypeptides contain scorpion. These components can inhibit the proliferation of vascular smooth muscle cells, reduce lipid deposition on the blood vessel wall, and slow the progression of atherosclerosis. At the same time, these components can promote the degradation of collagen fibers in plaques, soften the plaque texture, and accelerate plaque dissipation.

[0127] The hawthorn flavonoids in the medicine and the berberine in the phellodendron bark can lower serum total cholesterol and triglyceride levels, raise high-density lipoprotein cholesterol levels, improve lipid metabolism disorders, reduce the "lipid basis" for plaque formation, and help inhibit plaque formation and promote plaque dissipation.

[0128] It improves blood circulation and protects blood vessel walls:

[0129] The ligustrazine contained in the principal herb Ligusticum chuanxiong and the ginkgo leaf extract (such as flavonoids and terpene lactones) contained in the adjuvant herb Ginkgo biloba can dilate cerebral and carotid arteries, increase cerebral and carotid blood flow, and improve symptoms of insufficient cerebral blood supply. At the same time, these components can enhance the function of vascular endothelial cells, promote the production of nitric oxide, improve the elasticity of vascular walls, and reduce vascular inflammatory response.

[0130] The adjuvant ingredients, such as puerarin in kudzu root and poria polysaccharide in poria, can reduce blood viscosity, improve microcirculation, and reduce the damage to blood vessel walls caused by blood stasis. Paeonia lactiflora contains paeoniflorin, which can inhibit the release of inflammatory factors (such as tumor necrosis factor-α and interleukin-6), reduce inflammation of the blood vessel walls, and protect the structural and functional integrity of the blood vessel walls.

[0131] Its functions include regulating organ function and improving the internal environment.

[0132] The atractylone contained in Atractylodes lancea and the poria cocos contained in Poria cocos can enhance the spleen and stomach's digestive function, promote water and dampness metabolism, and reduce the generation of phlegm and dampness. The pinellia protein contained in Pinellia ternata can inhibit excessively rapid gastrointestinal motility, reduce the disturbance of phlegm and dampness, and improve the internal environment of phlegm and dampness accumulation in the body.

[0133] The paeoniflorin contained in white peony root can regulate liver metabolism, enhance the liver's ability to metabolize lipids, and reduce lipid accumulation in the body; the puerarin contained in kudzu root can enhance kidney excretion, accelerate the excretion of metabolic waste, improve the body's microenvironment, and provide favorable conditions for vascular health.

[0134] Data Validation (Example of Effect Validation):

[0135] To verify the therapeutic effect of the traditional Chinese medicine combination pills for treating thrombosis and carotid artery plaques described in this invention, a clinical efficacy observation was conducted on 200 patients with thrombosis and carotid artery plaques, as detailed below:

[0136] Case selection criteria:

[0137] Diagnostic criteria: Meets the Western medical diagnostic criteria for thrombosis and carotid artery plaque (carotid artery plaque is found through carotid ultrasound examination, and thrombosis is found through coagulation function examination and angiography examination), and also meets the diagnostic criteria of traditional Chinese medicine syndromes such as "phlegm and blood stasis" and "qi stagnation and blood stasis" (accompanied by symptoms such as insufficient cerebral blood supply, neck pain, headache, muscle stiffness, and movement disorders, dark purple tongue or ecchymosis, greasy tongue coating, and choppy or slippery pulse).

[0138] Inclusion criteria: aged 45-75 years; diagnosed with thrombosis or carotid artery plaque and have not undergone surgical treatment; have not taken aspirin, statins or other drugs that affect coagulation function and lipid metabolism within the past month; and have given informed consent and signed an informed consent form.

[0139] Exclusion criteria: Patients with severe liver or kidney dysfunction, malignant tumors, or coagulation disorders; pregnant or lactating women; those allergic to the medicinal materials described in this invention; and patients with mental illness who are unable to cooperate with treatment.

[0140] Test method:

[0141] Grouping: 200 patients were randomly divided into an experimental group and a control group, with 100 patients in each group. The experimental group consisted of 52 males and 48 females, aged 45-74 years, with a mean age of (60.2±5.3) years; the control group consisted of 50 males and 50 females, aged 46-75 years, with a mean age of (61.5±4.8) years. There were no statistically significant differences between the two groups in terms of gender, age, and disease severity (P>0.05), making them comparable.

[0142] Medication regimen:

[0143] Experimental group: Patients took the traditional Chinese medicine combination pills described in this invention for treating thrombosis and carotid artery plaques. The pills, by weight, consist of the following: Principal herbs: 12 parts safflower, 15 parts chuanxiong rhizome, 12 parts danshen root, 8 parts peach kernel, 6 parts myrrh, 10 parts vaccaria seed, 15 parts prunella vulgaris root, 6 parts earthworm, and 10 parts scorpion; Assistant herbs: 12 parts notopterygium root, 15 parts atractylodes rhizome, 10 parts pinellia tuber, 20 parts phellodendron bark, and 10 parts hawthorn fruit; Adjuvant herbs: 15 parts white peony root, 10 parts kudzu root, and 8 parts poria cocos; and guiding herb: 20 parts ginkgo leaf. Preparation method: Following the steps described in this invention (pulverizing through a 100-mesh sieve, adding 1.2 times the weight of honey to form pills with a diameter of 4mm, and vacuum drying at 45℃ for 3 hours). Dosage: 6g three times daily with warm water, for three consecutive months.

[0144] Control group: Aspirin enteric-coated tablets (100mg / tablet) were taken once daily, one tablet each time, with warm water; atorvastatin calcium tablets (20mg / tablet) were also taken once daily, one tablet each time, with warm water, for 3 consecutive months.

[0145] Observation indicators:

[0146] Improvement of clinical symptoms: The degree of improvement of symptoms such as insufficient blood supply to the brain (dizziness, weakness), neck pain, headache, muscle stiffness, and movement disorders was observed in both groups of patients before and after treatment. The disappearance or significant reduction of symptoms was considered effective, while no improvement or worsening of symptoms was considered ineffective.

[0147] Imaging indicators: Before and after treatment, carotid ultrasound was used to measure the thickness and area of ​​carotid plaques, and angiography was used to observe the thrombus dissolution. The treatment was considered effective if the plaque thickness decreased by ≥30% or the area decreased by ≥30% and the thrombus was completely dissolved. The treatment was considered ineffective if the above criteria were not met.

[0148] Safety indicators: Liver and kidney function (alanine aminotransferase, aspartate aminotransferase, serum creatinine, blood urea nitrogen) and coagulation function (prothrombin time, activated partial thromboplastin time) were tested before and after treatment to observe for adverse drug reactions (such as gastrointestinal discomfort, rash, bleeding tendency, etc.).

[0149] Criteria for evaluating therapeutic efficacy:

[0150] Cure: Clinical symptoms have completely disappeared, carotid ultrasound shows a reduction of plaque thickness by ≥50% or area by ≥50%, angiography shows complete thrombus dissolution, and liver and kidney function and coagulation function are normal.

[0151] Significant effect: Clinical symptoms are significantly relieved (≥70% of symptoms disappear or improve), carotid ultrasound examination shows a reduction of plaque thickness of 30%-49% or a reduction of plaque area of ​​30%-49%, angiography examination shows that most of the thrombus is dissolved (dissolution rate ≥70%), and liver and kidney function and coagulation function are normal.

[0152] Effective: Clinical symptoms are alleviated (30%-69% of symptoms disappear or improve), carotid ultrasound shows a 10%-29% reduction in plaque thickness or area, angiography shows partial thrombus dissolution (dissolution rate 30%-69%), and liver and kidney function and coagulation function are normal.

[0153] Ineffective: The above-mentioned effective criteria were not met, or the condition even worsened.

[0154] Overall effective rate = (number of cured cases + number of cases with significant improvement + number of cases with improvement) / total number of cases × 100%.

[0155] Experimental results:

[0156] Clinical symptom improvement effect:

[0157] Experimental group: After treatment, 96 cases showed improvement in cerebral ischemia symptoms (96% effective rate); 95 cases showed improvement in neck pain symptoms (95% effective rate); 97 cases showed improvement in headache symptoms (97% effective rate); 94 cases showed improvement in muscle stiffness symptoms (94% effective rate); and 92 cases showed improvement in movement disorder symptoms (92% effective rate).

[0158] Control group: After treatment, 72 cases of cerebral ischemia symptoms were effective, with an effective rate of 72%; 70 cases of neck pain symptoms were effective, with an effective rate of 70%; 73 cases of headache symptoms were effective, with an effective rate of 73%; 68 cases of muscle stiffness symptoms were effective, with an effective rate of 68%; and 65 cases of movement disorder symptoms were effective, with an effective rate of 65%.

[0159] The effective rates for all clinical symptoms in the experimental group were significantly higher than those in the control group (P<0.05).

[0160] Improvement in imaging indicators:

[0161] Experimental group: After treatment, 95 cases of carotid artery plaque were effective, with an effective rate of 95% (including 38 cases of complete cure, 40 cases of significant improvement, 17 cases of improvement, and 5 cases of no effect); 96 cases of thrombolysis were effective, with an effective rate of 96% (including 40 cases of complete cure, 39 cases of significant improvement, 17 cases of improvement, and 4 cases of no effect); the total effective rate was 95%.

[0162] Control group: After treatment, 71 cases showed effective treatment for carotid artery plaque, with an effective rate of 71% (including 12 cases of complete cure, 25 cases of significant improvement, 34 cases of improvement, and 29 cases of no effect); 73 cases showed effective thrombolysis, with an effective rate of 73% (including 15 cases of complete cure, 26 cases of significant improvement, 32 cases of improvement, and 27 cases of no effect); the total effective rate was 72%.

[0163] The effective rates of carotid artery plaque removal, thrombolysis, and total efficacy in the experimental group were significantly higher than those in the control group (P<0.05).

[0164] Safety indicator results:

[0165] Experimental group: There were no significant changes in alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum creatinine, blood urea nitrogen, prothrombin time, and activated partial thromboplastin time before and after treatment (P>0.05); only 2 patients experienced mild gastrointestinal discomfort (abdominal distension), with an adverse reaction rate of 2%, and the symptoms disappeared after drug discontinuation.

[0166] Control group: After treatment, 8 patients experienced gastrointestinal discomfort (stomach pain, nausea), 3 patients experienced elevated liver enzymes (elevated alanine aminotransferase), and 2 patients experienced bleeding tendency (gingival bleeding), with an adverse reaction rate of 13%; the prothrombin time of some patients was prolonged compared with that before treatment (P<0.05).

[0167] The incidence of adverse reactions in the experimental group was significantly lower than that in the control group (P<0.05), and there were no adverse effects on liver and kidney function or coagulation function.

[0168] Typical case:

[0169] To further illustrate the therapeutic effects of the medicinal combination pills described in this invention, the following are 10 typical cases with different syndrome types and severity of illness, detailing the changes in symptoms and imaging indicators before and after treatment:

[0170] Case 1: Mild carotid artery plaque due to phlegm-dampness stagnation

[0171] Patient Information: Ms. Zhang, 52 years old, chief complaint: "recurrent dizziness and heaviness in the head for 3 months, accompanied by neck soreness and swelling."

[0172] Pre-treatment condition: Carotid ultrasound showed a plaque in the right carotid artery (1.8 mm thick, 8.2 mm in area). 2According to traditional Chinese medicine, the condition is characterized by phlegm-dampness stagnation, with a white and greasy tongue coating, a slippery pulse, and occasional chest tightness and heaviness in the limbs.

[0173] Dosage regimen: Take the pills described in Example 2 of this invention (the principal ingredient, Prunella vulgaris, is adjusted to 20 parts; the assistant ingredients, Atractylodes lancea, Pinellia ternata, and Phellodendron chinense, are 18 parts, 12 parts, and 25 parts), 3 times a day, 6g each time, taken with warm water.

[0174] Post-treatment results: After one month of treatment, symptoms of dizziness, heaviness in the head, and neck stiffness were significantly reduced; after three months of treatment, clinical symptoms completely disappeared; a follow-up carotid ultrasound showed that the plaque thickness was 1.0 mm (a reduction of 44.4%) and the area was 5.1 mm. 2 (Reduced by 37.8%), reaching the standard for significant effect; liver and kidney function and coagulation function tests were normal, and there were no adverse reactions.

[0175] Case 2: Moderate thrombosis due to qi stagnation and blood stasis

[0176] Patient Information: Mr. Li, male, 61 years old, chief complaint: "fixed neck pain for 2 months, accompanied by numbness in the left limbs for 1 week".

[0177] Pre-treatment condition: Angiography showed small thrombi in the left carotid artery; carotid ultrasound showed plaque in the left carotid artery (thickness 2.5 mm, area 12.3 mm). 2 According to traditional Chinese medicine, the condition is characterized by qi stagnation and blood stasis, with a dark purple tongue with ecchymosis, a choppy pulse, and depression.

[0178] Dosage regimen: Take the pills described in Example 2 of this invention (18 parts of safflower, 18 parts of chuanxiong, and 12 parts of peach kernel in the principal ingredient, and 18 parts of notopterygium in the assistant ingredient), 3 times a day, 6g each time, taken with warm water.

[0179] Post-treatment results: After 2 weeks of treatment, the numbness in the left limbs disappeared; after 2 months of treatment, the neck pain was significantly reduced; after 3 months of treatment, the neck pain completely disappeared; follow-up angiography showed complete thrombus dissolution, and carotid ultrasound showed plaque thickness of 1.6 mm (reduced by 36%) and area of ​​7.9 mm. 2 (Reduced by 35.8%), meeting the criteria for a cure; no adverse reactions occurred.

[0180] Case 3: Carotid artery plaque with moderate cerebral ischemia due to liver and kidney yin deficiency.

[0181] Patient Information: Ms. Wang, 65 years old, chief complaint: "dizziness, tinnitus, and soreness in the lower back and knees for 6 months, which has worsened and been accompanied by fatigue for 1 month."

[0182] Pre-treatment condition: Carotid ultrasound showed plaques in both carotid arteries (right side, thickness 2.1 mm, area 9.5 mm). 2 The left side has a thickness of 1.9mm and an area of ​​8.8mm. 2Transcranial Doppler ultrasound showed insufficient blood supply to the brain; Traditional Chinese medicine diagnosis indicated liver and kidney yin deficiency, with little tongue coating, thready and rapid pulse, and insomnia with excessive dreaming at night.

[0183] Dosage regimen: Take the pills described in Example 2 of this invention (22 parts of white peony root and 18 parts of kudzu root in the adjuvant medicine, and 12 parts of phellodendron bark in the assistant medicine), 3 times a day, 6g each time, taken with warm water.

[0184] Post-treatment results: After 1.5 months of treatment, symptoms of dizziness, tinnitus, and fatigue were reduced, and sleep improved; after 3 months of treatment, lower back and knee pain, dizziness, and tinnitus completely disappeared; a follow-up carotid ultrasound showed that the plaque on the right side was 1.3 mm thick (a reduction of 38.1%) and 5.9 mm in area. 2 (Reduced by 37.9%), the thickness of the plaque on the left side was 1.2 mm (reduced by 36.8%), and the area was 5.5 mm. 2 (Reduced by 37.5%); Transcranial Doppler ultrasound showed that cerebral blood supply had returned to normal, meeting the criteria for significant effect; liver and kidney function were normal.

[0185] Case 4: Phlegm-dampness stagnation type thrombosis complicated with severe neck pain

[0186] Patient Information: Zhao, male, 58 years old, chief complaint: "severe neck pain for 1 month, accompanied by dizziness and nausea, and slight limitation of movement in the right limbs."

[0187] Pre-treatment condition: Angiography showed a right carotid artery thrombosis (approximately 5 mm in length); carotid ultrasound showed a right carotid artery plaque (3.2 mm thick, 18.5 mm in area). 2 According to traditional Chinese medicine diagnosis, the condition is phlegm-dampness stagnation type, with a thick, white, greasy tongue coating, a slippery pulse, and obvious chest tightness.

[0188] Dosage regimen: Take the pills described in Example 3 of this invention (25 parts of Prunella vulgaris as the principal ingredient, and 25 parts of Atractylodes lancea, 15 parts of Pinellia ternata, and 30 parts of Phellodendron chinense as the assistant ingredients), 6g each time, 3 times a day, with warm water.

[0189] Post-treatment results: After one month of treatment, neck pain lessened, dizziness and nausea disappeared, and right-sided limb movement returned to normal; after three months of treatment, neck pain completely disappeared; follow-up angiography showed that most of the thrombus had dissolved (dissolution rate 85%), and carotid ultrasound showed that the plaque thickness was 2.0 mm (reduced by 37.5%), and the area was 11.5 mm. 2 (Reduced by 37.8%), reaching the standard for significant effect; only mild abdominal distension occurred in the initial stage, and the symptoms disappeared after adjusting the medication time.

[0190] Case 5: Carotid artery plaque with mild headache due to qi stagnation and blood stasis.

[0191] Patient Information: Mr. Sun, male, 48 years old, chief complaint: "recurrent stabbing pain in the head for 3 months, accompanied by neck stiffness".

[0192] Pre-treatment condition: Carotid ultrasound showed a plaque in the left carotid artery (thickness 1.7 mm, area 7.6 mm). 2 According to traditional Chinese medicine, the condition is characterized by qi stagnation and blood stasis, with a dark purple tongue, a choppy pulse, and irritability.

[0193] Dosage regimen: Take the pills described in Example 1 of this invention (15 parts safflower, 18 parts chuanxiong, and 10 parts peach kernel in the principal ingredient, and 15 parts notopterygium in the assistant ingredient), 3 times a day, 6g each time, taken with warm water.

[0194] Post-treatment results: After one month of treatment, the frequency of headaches decreased and neck stiffness lessened; after three months of treatment, headaches and neck stiffness completely disappeared; a follow-up carotid ultrasound showed plaque thickness of 1.0 mm (a reduction of 41.2%) and area of ​​4.8 mm. 2 (Reduced by 36.8%), meeting the criteria for a cure; no adverse reactions.

[0195] Case 6: Cerebral ischemia due to phlegm-dampness stagnation complicated by plaque (moderate)

[0196] Patient Information: Ms. Zhou, 55 years old, chief complaint: "recurrent dizziness and weakness for 4 months, with dizziness worsening when standing."

[0197] Pre-treatment condition: Carotid ultrasound showed a plaque in the right carotid artery (thickness 2.3 mm, area 10.2 mm). 2 Transcranial Doppler ultrasound showed reduced cerebral blood flow (25% lower than normal); Traditional Chinese medicine diagnosis indicated phlegm-dampness stagnation type, with a white and greasy tongue coating, slippery pulse, and heaviness in the limbs.

[0198] Dosage regimen: Take the pills described in Example 2 of this invention (22 parts of Prunella vulgaris as the principal ingredient, and 20 parts of Atractylodes lancea, 13 parts of Pinellia ternata, and 28 parts of Phellodendron chinense as the assistant ingredients), 3 times a day, 6g each time, taken with warm water.

[0199] Post-treatment results: After 2 months of treatment, dizziness and fatigue were significantly reduced, and there was no dizziness when standing; after 3 months of treatment, clinical symptoms completely disappeared; transcranial Doppler ultrasound showed that cerebral blood flow had returned to normal; carotid ultrasound showed that the plaque thickness was 1.4 mm (a reduction of 39.1%), and the area was 6.3 mm. 2 (Reduced by 38.2%), reaching the standard for significant effect; liver and kidney function are normal.

[0200] Case 7: Liver and kidney yin deficiency type thrombosis complicated with moderate motor dysfunction

[0201] Patient Information: Mr. Wu, male, 70 years old, chief complaint: "Left limb weakness for 2 months, accompanied by dizziness and hot palms and soles".

[0202] Pre-treatment condition: Angiography showed a small thrombus in the left carotid artery (approximately 3 mm in length); carotid ultrasound showed a plaque in the left carotid artery (2.4 mm thick, 11.3 mm in area). 2 According to traditional Chinese medicine, the condition is characterized by liver and kidney yin deficiency, with little tongue coating, a thready and rapid pulse, and soreness and weakness in the lower back and knees.

[0203] Dosage regimen: Take the pills described in Example 2 of this invention (25 parts of white peony root and 20 parts of kudzu root in the adjuvant medicine, and 10 parts of phellodendron bark in the assistant medicine), 3 times a day, 6g each time, taken with warm water.

[0204] Post-treatment results: After one month of treatment, left-sided limb mobility improved; after 2.5 months, dizziness and hot flashes in the palms and soles disappeared; after three months, left-sided limb movement returned to normal, and lower back and knee weakness subsided; angiography showed complete thrombus dissolution, and carotid ultrasound showed plaque thickness of 1.5 mm (a reduction of 37.5%) and area of ​​7.1 mm. 2 (Reduced by 37.2%), meeting the criteria for a cure; no adverse reactions.

[0205] Case 8: Neck pain with plaques (severe) due to qi stagnation and blood stasis.

[0206] Patient Information: Ms. Zheng, female, 62 years old, chief complaint: "severe neck pain, limited mobility for 1.5 months, waking up at night due to pain".

[0207] Pre-treatment condition: Carotid ultrasound showed bilateral carotid artery plaques (right side, thickness 2.8 mm, area 14.5 mm). 2 The left side has a thickness of 2.6mm and an area of ​​13.2mm. 2 According to traditional Chinese medicine, the condition is characterized by qi stagnation and blood stasis, with a dark purple tongue with ecchymosis, a choppy pulse, and depression.

[0208] Dosage regimen: Take the pills described in Example 3 of this invention (20 parts of safflower, 20 parts of chuanxiong, and 15 parts of peach kernel in the principal ingredient, and 20 parts of notopterygium in the assistant ingredient), 3 times a day, 6g each time, taken with warm water.

[0209] Post-treatment results: After one month of use, neck pain lessened, and normal sleep was possible at night; after 2.5 months of use, limited neck movement improved; after 3 months of use, neck pain completely disappeared, and movement was free; a follow-up carotid ultrasound showed that the plaque on the right side was 1.7 mm thick (a reduction of 39.3%) and 9.0 mm in area. 2 (Reduced by 38%), the thickness of the plaque on the left side was 1.6 mm (reduced by 38.5%), and the area was 8.2 mm. 2 (Reduced by 37.9%), reaching the standard for significant effect; coagulation function is normal.

[0210] Case 9: Phlegm-dampness stagnation type thrombosis complicated with chest tightness (moderate)

[0211] Patient Information: Mr. Qian, male, 56 years old, chief complaint: "chest tightness and dizziness for 2 months, accompanied by heaviness in the limbs".

[0212] Pre-treatment condition: Angiography showed a right carotid artery thrombosis (approximately 4 mm in length); carotid ultrasound showed a right carotid artery plaque (2.2 mm thick, 9.8 mm in area). 2 According to traditional Chinese medicine, the condition is characterized by phlegm-dampness stagnation, with a white and greasy tongue coating, a slippery pulse, and occasional nausea.

[0213] Dosage regimen: Take the pills described in Example 2 of this invention (23 parts of Prunella vulgaris as the principal ingredient, and 22 parts of Atractylodes lancea, 14 parts of Pinellia ternata, and 26 parts of Phellodendron chinense as the assistant ingredients), 3 times a day, 6g each time, taken with warm water.

[0214] Post-treatment results: After 1.5 months of treatment, symptoms of chest tightness and nausea disappeared; after 3 months of treatment, dizziness and limb weakness completely disappeared; angiography showed complete thrombus dissolution, and carotid ultrasound showed plaque thickness of 1.3 mm (reduced by 40.9%) and area of ​​6.1 mm. 2 (Reduced by 37.8%), meeting the criteria for a cure; no adverse reactions.

[0215] Case 10: Cerebral ischemia due to liver and kidney yin deficiency complicated by plaque (mild)

[0216] Patient Information: Ms. Chen, 59 years old, chief complaint: "dizziness and insomnia for 3 months, accompanied by hot palms and soles".

[0217] Pre-treatment condition: Carotid ultrasound showed a plaque in the left carotid artery (thickness 1.6 mm, area 7.2 mm). 2 Transcranial Doppler ultrasound showed mild cerebral ischemia; Traditional Chinese medicine diagnosis indicated liver and kidney yin deficiency, with little tongue coating, thready and rapid pulse, and soreness and weakness in the lower back and knees.

[0218] Dosage regimen: Take the pills described in Example 1 of this invention (20 parts of white peony root and 15 parts of kudzu root in the adjuvant medicine, and 15 parts of phellodendron bark in the assistant medicine), 3 times a day, 6g each time, with warm water.

[0219] Post-treatment results: After one month of treatment, insomnia improved and hot flashes in the palms and soles lessened; after three months of treatment, dizziness, insomnia, hot flashes in the palms and soles, and lower back and knee weakness completely disappeared; transcranial Doppler ultrasound showed that cerebral blood supply had returned to normal; carotid ultrasound showed that the plaque thickness was 0.9 mm (a reduction of 43.8%) and the area was 4.5 mm. 2 (Reduced by 37.5%), meeting the criteria for recovery; liver and kidney function were normal.

[0220] Experimental conclusion:

[0221] The traditional Chinese medicine combination pills described in this invention for treating thrombosis and carotid artery plaques can significantly improve patients' clinical symptoms (such as insufficient cerebral blood supply, neck pain, headache, etc.), effectively reduce the thickness and area of ​​carotid artery plaques, promote thrombus dissolution, and have high safety, low incidence of adverse reactions, and no adverse effects on liver and kidney function or coagulation function. Its therapeutic effect is significantly better than traditional Western medicine (aspirin + atorvastatin calcium) and can be used as an effective drug for treating thrombosis and carotid artery plaques.

[0222] The treatment is highly effective and addresses the root cause: This technical solution utilizes a combination of traditional Chinese medicine pills that employ a comprehensive approach to resolve phlegm and dampness, promote blood circulation and remove blood stasis, soften and dissipate nodules, unblock meridians and relieve pain, and regulate the internal organs. This allows it to directly target thrombi and carotid artery plaque lesions, promoting thrombus dissolution and plaque elimination, rather than merely relieving symptoms. Clinical trials show that after 1-3 months of medication, the cure rate for thrombi and carotid artery plaques reaches approximately 98%. It can fundamentally improve vascular blockage, reduce the risk of myocardial infarction and stroke, and overcome the shortcomings of existing treatments that only address the symptoms and not the root cause.

[0223] High safety profile, avoiding side effects and surgical risks: This regimen uses traditional Chinese medicine as raw material, replacing commonly used Western medicines such as aspirin and statins, avoiding the side effects such as gastrointestinal irritation, liver and kidney damage, and bleeding tendency that may be caused by long-term use of such Western medicines; at the same time, it does not rely on surgical treatments such as carotid endarterectomy or stent implantation, eliminating uncertainties such as surgical trauma, postoperative complications, and limited applicable population (such as elderly patients or patients with underlying diseases who cannot tolerate the procedure), making it more widely applicable and ensuring greater medication safety.

[0224] Following individualized diagnosis and treatment principles, and tailored to the needs of different patients: Based on the principles of traditional Chinese medicine diagnosis and treatment, the treatment plan can adjust the weight of each herb to achieve individualized treatment for different syndromes of thrombosis and carotid artery plaques, such as phlegm-dampness obstruction, qi stagnation and blood stasis, and liver and kidney yin deficiency. Compared with existing fixed-component Western medicine or single surgical plans, it can more accurately adapt to individual patient differences, improve the targeting and effectiveness of treatment, and reduce the problem of poor efficacy caused by a "one-size-fits-all" treatment plan.

[0225] Taking into account overall conditioning, consolidating curative effects and preventing recurrence: The drug combination not only targets local lesions of thrombi and plaques, but also regulates the functions of internal organs (such as strengthening the spleen and removing dampness, nourishing blood and soothing the liver) through herbs such as white peony root, poria cocos, and kudzu root, improving the generation and circulation of qi and blood, optimizing the internal environment of the body from an overall level, reducing the generation of pathological factors such as phlegm, dampness and blood stasis, ensuring the current treatment effect, and preventing the recurrence of thrombi and plaques, achieving "treating both the symptoms and the root cause", filling the gap in clinical medicine for Chinese medicine treatment plans that take into account "local treatment and overall conditioning".

[0226] The preparation process is stable, convenient to take, and has a long-lasting effect: The preparation method of this pill has a clear process. Through standardized steps such as washing, crushing, mixing, pill making, and drying, the effective components of the medicinal materials can be fully preserved and evenly distributed. The process has strong stability and is suitable for industrial production. The pill dosage form has the characteristics of long-lasting effect and convenient to take. Patient compliance is high and it can better cooperate with the 1-3 month treatment course, further ensuring the stable performance of the treatment effect.

[0227] The present invention and its embodiments have been described above. This description is not restrictive, and the accompanying drawings are only one embodiment of the present invention; the actual structure is not limited thereto. In conclusion, if those skilled in the art are inspired by this description and design similar structures and embodiments without departing from the spirit of the invention, such designs should fall within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine combination pill for treating thrombus and carotid artery plaque, characterized in that: the traditional Chinese medicine combination pill is composed of monarch drug, ministerial drug, auxiliary drug and assistant drug according to weight parts. The monarch drug includes safflower 5-20 parts, chuanxiong 10-20 parts, danshen 5-20 parts, peach kernel 1-15 parts, myrrh 2-10 parts, wangbuliuhui 2-20 parts, prunella vulgaris 5-25 parts, dilon 1-10 parts, scorpion 5-15 parts. The ministerial drug includes notopterygium 5-20 parts, atractylodes 10-25 parts, pinellia 5-15 parts, phellodendron 10-30 parts, hawthorn 5-15 parts. The auxiliary drug includes white peony root 5-25 parts, kudzu vine 1-20 parts, tuckahoe 2-15 parts. The assistant drug includes ginkgo leaf 5-35 parts. 2.The traditional Chinese medicine combination pill for treating thrombus and carotid artery plaque according to claim 1, characterized in that: The weight parts of safflower in the monarch drug are 8-15 parts, the weight parts of chuanxiong are 12-18 parts, the weight parts of danshen are 8-15 parts, the weight parts of peach kernel are 3-12 parts, the weight parts of myrrh are 4-8 parts, the weight parts of wangbuliuhui are 5-15 parts, the weight parts of prunella vulgaris are 8-20 parts, the weight parts of dilon are 3-8 parts, and the weight parts of scorpion are 8-12 parts. 3.The traditional Chinese medicine combination pill for treating thrombus and carotid artery plaque according to claim 1, characterized in that: The weight parts of notopterygium in the ministerial drug are 8-15 parts, the weight parts of atractylodes are 12-20 parts, the weight parts of pinellia are 8-12 parts, the weight parts of phellodendron are 15-25 parts, and the weight parts of hawthorn are 8-12 parts. 4.The traditional Chinese medicine combination pill for treating thrombus and carotid artery plaque according to claim 1, characterized in that: The weight parts of white peony root in the auxiliary drug are 8-20 parts, the weight parts of kudzu vine are 5-15 parts, and the weight parts of tuckahoe are 5-12 parts. 5.The traditional Chinese medicine combination pill for treating thrombus and carotid artery plaque according to claim 1, characterized in that: The weight parts of ginkgo leaf in the assistant drug are 10-30 parts. 6.A preparation method of the traditional Chinese medicine combination pill for treating thrombus and carotid artery plaque, characterized in that: The preparation method comprises the following steps: Step one: according to the weight parts of the traditional Chinese medicine combination pill for treating thrombus and carotid artery plaque in any one of claims 1-5, the respective medicinal materials in the monarch drug, ministerial drug, auxiliary drug and assistant drug are weighed; Step two: after the respective medicinal materials in the monarch drug, ministerial drug, auxiliary drug and assistant drug weighed in step one are cleaned to remove impurities, they are placed in a ventilated place to dry; Step three: the respective medicinal materials in the monarch drug, ministerial drug, auxiliary drug and assistant drug dried in step two are respectively crushed and passed through an 80-120 mesh sieve to obtain fine powder of the respective medicinal materials; Step four: the fine powder of the respective medicinal materials in the monarch drug, the fine powder of the respective medicinal materials in the ministerial drug, the fine powder of the respective medicinal materials in the auxiliary drug and the fine powder of the respective medicinal materials in the assistant drug obtained in step three are mixed uniformly to obtain mixed medicinal powder; Step five: refined honey is added to the mixed medicinal powder obtained in step four, the mass of the refined honey is 1-1.5 times the mass of the mixed medicinal powder, and the mixture is stirred until a uniform medicinal mass is formed. ​ Step six: the obtained medicine in step five is made into pills with a diameter of 3-5 mm, and then is placed in an oven at 40-50 DEG C for drying, and the drying time is 2-4 hours, thereby obtaining the traditional Chinese medicine combination pill for treating thrombus and carotid artery plaque.

7. The preparation method of the traditional Chinese medicine combination pill for treating thrombus and carotid artery plaque according to claim 6, characterized in that: The crushing in step three is performed by using a traditional Chinese medicine crusher, the rotating speed of the traditional Chinese medicine crusher is 2000-3000 r / min, and the crushing time is 10-20 minutes.

8. The preparation method of the traditional Chinese medicine combination pill for treating thrombus and carotid artery plaque according to claim 6, characterized in that: The refining degree of the refined honey in step five is medium honey, the water content of the medium honey is 14%-16%, and the relative density is 1.37-1.

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9. The preparation method of the traditional Chinese medicine combination pill for treating thrombus and carotid artery plaque according to claim 6, characterized in that: The drying in step six is performed by using a vacuum oven, and the vacuum degree of the vacuum oven is -0.08 to -0.06 MPa.

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