Preparation method and device of pharmaceutical composition for treating myocardial ischemia

Abstract

The invention relates to the technical field of medicine, in particular to a preparation method and device of a pharmaceutical composition for treating myocardial ischemia, and the device comprises a mounting seat, an extrusion mechanism, a fixed pelleting plate, a moving mechanism, a movable pelleting plate and a collecting mechanism; a medicine lump prepared from medicinal raw materials is put into the extrusion mechanism, continuous long-strip-shaped medicine is extruded, the long-strip-shaped medicine falls till the tail end is aligned with the bottom end of the fixed pelleting plate, then extrusion is stopped, the moving mechanism drives the movable pelleting plate to be close to the fixed pelleting plate, and the long-strip-shaped medicine is divided into multiple sections; then the moving mechanism drives the moving pill making plate to start to move in the length direction of the first pill making groove, the medicine divided into the multiple sections is rubbed into multiple pills, and the pills are collected by the collecting mechanism; the problems that pills prepared in the prior art are often insufficient in roundness, rough in surface and irregular in shape, the appearance quality of products is affected, and adverse effects can be possibly generated on subsequent drying uniformity, coating consistency and patient taking experience are solved.

Description

Technical Field

[0001] This invention relates to the field of medical technology, and in particular to a method and apparatus for preparing a pharmaceutical composition for treating myocardial ischemia. Background Technology

[0002] With the continuous development of traditional Chinese medicine and its increasing clinical acceptance, Chinese herbal medicines are receiving increasing attention in the prevention and treatment of cardiovascular diseases such as myocardial ischemia due to their advantages such as strong overall regulatory effects, good tolerability, and relatively few toxic side effects. Currently, Chinese herbal preparations for treating myocardial ischemia are often used in the form of pills. Their preparation process typically includes multiple steps such as pulverizing medicinal materials, extracting and concentrating into a paste, refining and mixing the medicine, making pills, shaping and sieving, vacuum drying, and selecting the pills.

[0003] In existing pelleting processes, double-toothed disc pelleting machines are commonly used for forming operations: uniformly refined medicinal materials are extruded into strips by an extrusion device, and then sheared and pre-rounded by a pair of relatively rotating grooved toothed discs to obtain granular pills.

[0004] However, this method has obvious drawbacks. Since the bi-toothed disc mainly relies on mechanical shearing and limited extrusion to complete the division, it lacks sufficient rolling and shaping processes. As a result, the pills produced are often not round enough, have rough surfaces, and are irregular in shape. This not only affects the appearance quality of the product, but may also have an adverse effect on the subsequent drying uniformity, coating consistency, and patient experience. Summary of the Invention

[0005] The purpose of this invention is to provide a method and apparatus for preparing a pharmaceutical composition for treating myocardial ischemia, aiming to solve the problem that the pills prepared by the prior art often have insufficient roundness, rough surface and irregular shape, which not only affects the appearance quality of the product, but may also have an adverse effect on the subsequent drying uniformity, coating consistency and patient experience.

[0006] To achieve the above objectives, the present invention provides a pharmaceutical composition preparation apparatus for treating myocardial ischemia, comprising a mounting base, an extrusion mechanism, a fixed pelleting plate, a moving mechanism, a moving pelleting plate, and a collection mechanism; The extrusion mechanism is located on the top of the mounting base; the fixed pelleting plate is fixedly located on one side of the mounting base; the fixed pelleting plate is provided with a plurality of first pelleting grooves; the moving mechanism is located on one side of the mounting base; the moving pelleting plate is located on the moving mechanism; the moving pelleting plate is provided with a plurality of second pelleting grooves; the moving mechanism can drive the moving pelleting plate to move in a direction perpendicular to the fixed pelleting plate, and can also drive the moving pelleting plate to move along the length direction of the first pelleting grooves; the collecting mechanism is located on one side of the mounting base for collecting the prepared pellets.

[0007] The extrusion mechanism includes an extrusion cylinder, an extrusion head, a first rotating shaft, helical blades, and a first motor. The extrusion cylinder is fixedly mounted on the top of the mounting base; the extrusion head is fixedly mounted on one side of the extrusion cylinder and communicates with the extrusion cylinder; the first rotating shaft is rotatably mounted inside the extrusion cylinder; the spiral blade is fixedly mounted on the first rotating shaft; the first motor is fixedly mounted on one side of the extrusion cylinder, and the output end of the first motor is fixedly connected to the first rotating shaft.

[0008] The extrusion mechanism further includes a feed hopper; The feed hopper is fixedly disposed at the top of the extrusion cylinder and is in communication with the extrusion cylinder.

[0009] The extrusion mechanism further includes a second rotating shaft, a second motor, and a pressure block; The second rotating shaft is rotatably disposed inside the feed hopper; the second motor is fixedly disposed on one side of the feed hopper, and the output end of the second motor is fixedly connected to the second rotating shaft; the pressure block is fixedly disposed on the second rotating shaft.

[0010] The moving mechanism includes a guide rail, a sliding seat, a first hydraulic cylinder, a bracket, multiple guide rods, and a second hydraulic cylinder. The guide rail is fixedly mounted on one side of the mounting base; the sliding seat is slidably mounted on the guide rail; the first hydraulic cylinder is fixedly mounted on the guide rail, and the output end of the first hydraulic cylinder is fixedly connected to the sliding seat; the bracket is fixedly mounted on the sliding seat; a plurality of guide rods are respectively fixedly connected to the movable pelletizing plate and slidably connected to the bracket, and respectively pass through the bracket; the second hydraulic cylinder is fixedly mounted on the bracket, and the output end of the second hydraulic cylinder is fixedly connected to the movable pelletizing plate.

[0011] The collection mechanism includes multiple inclined guide slides and a collection slide; Multiple inclined guide slides are fixedly installed on one side of the mounting base, and the multiple inclined guide slides are connected to multiple first pelleting grooves in a one-to-one correspondence, for guiding the formed pellets to roll down; the collecting slide is fixedly installed on one side of the mounting base, for catching the pellets that slide down from the multiple inclined guide slides.

[0012] The collection mechanism also includes a collection tray; The collection tray is fixedly installed on one side of the mounting base to catch the pills that roll down from the collection slide.

[0013] The apparatus for preparing the drug composition for treating myocardial ischemia also includes a shunt tube and multiple air-blowing discs. The diversion pipe is fixedly installed on one side of the movable pelletizing plate; the multiple air blowing discs are respectively connected to one side of the diversion pipe and are connected to the multiple second pelletizing grooves one by one.

[0014] This invention also provides a method for preparing a pharmaceutical composition for treating myocardial ischemia, the specific steps of which include: Weigh out the corresponding weight proportions of each medicinal material, stir-fry them, pulverize them, and sieve them to make powdered raw materials; Powdered ingredients, salt water, vegetable oil, and maltodextrin are mixed in a mixer to form a thick paste; The thick paste is made into qualified medicine lumps; The dextrose is placed into the extrusion mechanism, which extrudes long strips of medicine that fall between the fixed pelleting plate and the moving pelleting plate. After the moving mechanism drives the moving pelleting plate to approach and close the fixed pelleting plate, it drives the moving pelleting plate to start moving along the length of the first pelleting groove. The long strips of medicine were rolled into multiple spherical pills and collected by a collection agency; The collected pills are vacuum dried and then packaged.

[0015] In the step of weighing the corresponding proportions of each medicinal material, frying them, pulverizing them, and sieving them to make powdered raw materials: The medicinal materials, by weight, include: 15-25 parts of Panax notoginseng, 15-25 parts of Salvia miltiorrhiza, 20-30 parts of Astragalus membranaceus, 0.5-2 parts of Strychnos nux-vomica, 10-20 parts of Achyranthes bidentata, 5-10 parts of Pueraria lobata, 0.5-2 parts of Calculus bovis, 5-10 parts of Ginkgo biloba, 1-3 parts of Phellodendron chinense, and 1-3 parts of Ilex chinensis.

[0016] This invention discloses a method and apparatus for preparing a pharmaceutical composition for treating myocardial ischemia. In use, a clump of medicinal material is placed into an extrusion mechanism. The clump should be of moderate firmness, able to clump together when squeezed, and easily dispersed upon light pressure. The extrusion mechanism extrudes a continuous strip of drug. Under gravity, the strip falls between a fixed pelleting plate and a movable pelleting plate until its end aligns with the bottom of the fixed pelleting plate. Extrusion then stops. The movable mechanism moves the movable pelleting plate closer to the fixed pelleting plate, dividing the strip of drug into multiple segments. Then, the movable mechanism moves the movable pelleting plate along the length of the first pelleting groove. With the cooperation of the first and second pelleting troughs, the drug, which has been divided into multiple segments, is rolled into multiple pills. Subsequently, the moving pelleting plate stops abruptly, and under the action of inertia, the pills roll out from between the first and second pelleting troughs and are collected by the collecting mechanism. The relative sliding between the moving and fixed pelleting plates is used to roll the pills, which realizes a full rolling and shaping process. This solves the problem that the pills produced by the existing technology are often not round enough, have a rough surface, and are irregular in shape. This not only affects the appearance quality of the product, but may also have an adverse effect on the subsequent drying uniformity, coating consistency, and patient experience. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the accompanying drawings used in the description of the embodiments or the prior art will be briefly introduced below.

[0018] Figure 1 This is a schematic diagram of the structure of the first embodiment of the present invention.

[0019] Figure 2 This is a structural schematic diagram of the first embodiment of the present invention from another angle.

[0020] Figure 3 This is a structural schematic diagram of the first embodiment of the present invention from another angle.

[0021] Figure 4 This is a right view of the first embodiment of the present invention.

[0022] Figure 5 yes Figure 4 A cross-sectional view along the AA direction.

[0023] Figure 6 This is a rear view of the first embodiment of the present invention.

[0024] Figure 7 yes Figure 6 A cross-sectional view along the BB direction.

[0025] Figure 8 This is a flowchart illustrating the second embodiment of the present invention.

[0026] 1-Mounting base, 2-Extrusion mechanism, 3-Fixed pelletizing plate, 4-Moving mechanism, 5-Moving pelletizing plate, 6-Collection mechanism, 7-Diverter pipe, 8-Blowing disc, 21-Extrusion cylinder, 22-Extrusion head, 23-First rotating shaft, 24-Helical blade, 25-First motor, 26-Feed hopper, 27-Second rotating shaft, 28-Second motor, 29-Pressure block, 31-First pelletizing trough, 41-Guide rail, 42-Sliding seat, 43-First hydraulic cylinder, 44-Bracket, 45-Guide rod, 46-Second hydraulic cylinder, 51-Second pelletizing trough, 61-Inclined guide slide, 62-Collection slide, 63-Collection tray. Detailed Implementation

[0027] The first embodiment of this application is as follows: Please see Figures 1-7 ,in, Figure 1 This is a schematic diagram of the structure of the first embodiment of the present invention. Figure 2 This is a structural schematic diagram of the first embodiment of the present invention from another angle. Figure 3 This is a structural schematic diagram of the first embodiment of the present invention from another angle. Figure 4 This is a right view of the first embodiment of the present invention. Figure 5 yes Figure 4 A cross-sectional view along the AA direction. Figure 6 This is a rear view of the first embodiment of the present invention. Figure 7 yes Figure 6 A cross-sectional view along the BB direction.

[0028] This invention provides a pharmaceutical composition preparation apparatus for treating myocardial ischemia: comprising a mounting base 1, an extrusion mechanism 2, a fixed pelletizing plate 3, a moving mechanism 4, a moving pelletizing plate 5, and a collecting mechanism 6; the fixed pelletizing plate 3 is provided with a plurality of first pelletizing grooves 31; the moving pelletizing plate 5 is provided with a plurality of second pelletizing grooves 51; the extrusion mechanism 2 includes an extrusion cylinder 21, an extrusion head 22, a first rotating shaft 23, a spiral blade 24, and a first motor 25; the extrusion mechanism 2 also includes a feeding hopper 26; the extrusion mechanism 2 also includes a second rotating shaft 27, a second motor 28, and a pressing block 29; the moving mechanism 4... The device includes a guide rail 41, a sliding seat 42, a first hydraulic cylinder 43, a bracket 44, multiple guide rods 45, and a second hydraulic cylinder 46; the collection mechanism 6 includes multiple inclined guide slides 61 and a collection slide 62; the collection mechanism 6 also includes a collection tray 63; the drug composition preparation device for treating myocardial ischemia also includes a diversion pipe 7 and multiple blowing discs 8; the aforementioned solution solves the problem that the pills produced by the prior art often have insufficient roundness, rough surface, and irregular shape, which not only affects the appearance quality of the product, but may also adversely affect the subsequent drying uniformity, coating consistency, and patient experience.

[0029] Furthermore, the extrusion mechanism 2 is disposed on the top of the mounting base 1; the fixed pelleting plate 3 is fixedly disposed on one side of the mounting base 1; the fixed pelleting plate 3 is provided with a plurality of first pelleting grooves 31; the moving mechanism 4 is disposed on one side of the mounting base 1; the moving pelleting plate 5 is disposed on the moving mechanism 4; the moving pelleting plate 5 is provided with a plurality of second pelleting grooves 51; the moving mechanism 4 can drive the moving pelleting plate 5 to move in a direction perpendicular to the fixed pelleting plate 3, and can also drive the moving pelleting plate 5 to move along the length direction of the first pelleting grooves 31; the collecting mechanism 6 is disposed on one side of the mounting base 1 for collecting the prepared pellets.

[0030] In this embodiment, the extrusion mechanism 2 is used to continuously extrude long strips of medicine; the movable pelleting plate 5 and the fixed pelleting plate 3 have the same shape and specifications, the first pelleting groove 31 and the second pelleting groove 51 have the same shape and specifications, and their cross-sections are both semi-circular. After the movable pelleting plate 5 moves close to the fixed pelleting plate 3, the first pelleting groove 31 and the second pelleting groove 51 just form a cylindrical channel with a complete circular cross-section. In use, the medicinal material is placed into the extrusion mechanism 2. The material should be of moderate firmness, able to be formed into a ball when squeezed, and easily dispersed when lightly pressed. The extrusion mechanism 2 extrudes a continuous strip of medicine. Under the influence of gravity, the strip falls between the fixed pelleting plate 3 and the movable pelleting plate 5 until its end aligns with the bottom of the fixed pelleting plate 3. Extrusion then stops. The movable mechanism 4 moves the movable pelleting plate 5 closer to the fixed pelleting plate 3, dividing the strip of medicine into multiple segments. Then, the movable mechanism 4 moves the movable pelleting plate 5 along the length of the first pelleting groove 31. With the cooperation of the second pelleting trough 51, the drug divided into multiple segments is rolled into multiple pills. Subsequently, the moving pelleting plate 5 stops abruptly, and under the action of inertia, the pills roll out from between the first pelleting trough 31 and the second pelleting trough 51 and are collected by the collecting mechanism 6. The relative sliding between the moving pelleting plate 5 and the fixed pelleting plate 3 is used to roll the pills, realizing a full rolling and shaping process. This solves the problem that the pills produced by the existing technology are often not round enough, have a rough surface, and are irregular in shape, which not only affects the appearance quality of the product, but may also have an adverse effect on the subsequent drying uniformity, coating consistency and patient experience.

[0031] Furthermore, the extrusion cylinder 21 is fixedly disposed on the top of the mounting base 1; the extrusion head 22 is fixedly disposed on one side of the extrusion cylinder 21 and communicates with the extrusion cylinder 21; the first rotating shaft 23 is rotatably disposed inside the extrusion cylinder 21; the spiral blade 24 is fixedly disposed on the first rotating shaft 23; the first motor 25 is fixedly disposed on one side of the extrusion cylinder 21, and the output end of the first motor 25 is fixedly connected to the first rotating shaft 23.

[0032] In this embodiment, the extrusion cylinder 21 is arranged horizontally, the first motor 25 drives the first rotating shaft 23 to rotate, and the first rotating shaft 23 drives the spiral blade 24 to rotate, realizing spiral feeding. After the drug is delivered to the end of the extrusion cylinder 21, it is extruded from the extrusion head 22 to form a continuous strip of drug.

[0033] Furthermore, the feed hopper 26 is fixedly disposed on the top of the extrusion cylinder 21 and communicates with the extrusion cylinder 21.

[0034] In this embodiment, the feed hopper 26 is connected to the opening at the top of the extrusion cylinder 21, and is used to put in a prepared clump of medicine that is of moderate softness and hardness, can be formed into a ball by hand, and can be dispersed by light pressure.

[0035] Furthermore, the second rotating shaft 27 is rotatably disposed inside the feed hopper 26; the second motor 28 is fixedly disposed on one side of the feed hopper 26, and the output end of the second motor 28 is fixedly connected to the second rotating shaft 27; the pressure block 29 is fixedly disposed on the second rotating shaft 27.

[0036] In this embodiment, the cross-section of the pressing block 29 is triangular. The second motor 28 drives the second rotating shaft 27 to rotate, which in turn drives the pressing block 29 to rotate inside the feed hopper 26. As the pressing block 29 rotates, the drug clump is gradually pressed into the extrusion cylinder 21.

[0037] Furthermore, the guide rail 41 is fixedly mounted on one side of the mounting base 1; the sliding seat 42 is slidably mounted on the guide rail 41; the first hydraulic cylinder 43 is fixedly mounted on the guide rail 41, and the output end of the first hydraulic cylinder 43 is fixedly connected to the sliding seat 42; the bracket 44 is fixedly mounted on the sliding seat 42; a plurality of guide rods 45 are respectively fixedly connected to the movable pelletizing plate 5, and respectively slidably connected to the bracket 44, and respectively pass through the bracket 44; the second hydraulic cylinder 46 is fixedly mounted on the bracket 44, and the output end of the second hydraulic cylinder 46 is fixedly connected to the movable pelletizing plate 5.

[0038] In this embodiment, the guide rail 41 is used to slide the sliding seat 42, and the first hydraulic cylinder 43 is used to drive the sliding seat 42 to slide, thereby driving the movable pelletizing plate 5 to move along the length direction of the first pelletizing groove 31; the sliding direction of the plurality of guide rods 45 is perpendicular to the fixed pelletizing plate 3, and the second hydraulic cylinder 46 is used to drive the movable pelletizing plate 5 to move in a direction perpendicular to the fixed pelletizing plate 3.

[0039] Furthermore, multiple inclined guide slides 61 are fixedly disposed on one side of the mounting base 1, and the multiple inclined guide slides 61 are connected to multiple first pelleting grooves 31 in a one-to-one correspondence, for guiding the formed pellets to roll down; the collecting slide 62 is fixedly disposed on one side of the mounting base 1 for catching the pellets that slide down from the multiple inclined guide slides 61.

[0040] In this embodiment, the multiple inclined guide slides 61 have the same function but different lengths to align the outlet with the collecting slide 62, and all have a certain slope. The inlet of the inclined guide slide 61 is connected to the first pelleting groove 31. After the moving pelleting plate 5 and the fixed pelleting plate 3 come together to form pellets, the moving pelleting plate 5 stops abruptly, and both its left and right ends are aligned with the fixed pelleting plate 3. Therefore, the second pelleting groove 51 is also aligned and connected with the inlet of the inclined guide slide 61. The pellet rolls out from the cylindrical channel formed by the first pelleting groove 31 and the second pelleting groove 51 and rolls into the inclined guide slide 61. Then, it rolls down the inclined guide slide 61 into the collecting slide 62. The cross-sectional shape of the path of the inclined guide slide 61 and the collecting slide 62 is a semi-circle slightly larger than the diameter of the pellet. The pellet continues to be plasticized during rolling, so that the pellet can become rounder and rounder as it rolls.

[0041] Furthermore, the collection tray 63 is fixedly disposed on one side of the mounting base 1 to catch the pills rolling down from the collection slide 62.

[0042] In this embodiment, the pill continues to roll down the collection chute 62 and finally falls into the collection tray 63.

[0043] Furthermore, the diversion pipe 7 is fixedly disposed on one side of the movable pelletizing plate 5; the plurality of air blowing discs 8 are respectively connected to one side of the diversion pipe 7 and are connected to the plurality of second pelletizing grooves 51 in a one-to-one correspondence.

[0044] In this embodiment, the diversion pipe 7 is installed on one side of the movable pelleting plate 5 via a support plate and needs to be connected to an external high-pressure air source via a hose. Since the pellets have a certain degree of stickiness, the rolled pellets may not be able to roll out of the cylindrical channel formed by the first pelleting groove 31 and the second pelleting groove 51 due to inertia. Therefore, after the movable pelleting plate 5 stops suddenly, the left and right ends of the movable pelleting plate 5 are aligned with the fixed pelleting plate 3. At this time, the air blowing disc 8 is just aligned with the right end of the first pelleting groove 31 and the second pelleting groove 51. The air blowing disc 8 blows out gas to blow out the pellets.

[0045] The apparatus for preparing a drug composition for treating myocardial ischemia described in this embodiment involves placing a clump of medicinal material into the extrusion mechanism 2. The clump should be of moderate firmness, able to clump together when squeezed, and easily dispersed when lightly pressed. The extrusion mechanism 2 extrudes a continuous strip of drug. Under the influence of gravity, the strip falls between the fixed pelleting plate 3 and the movable pelleting plate 5 until its end aligns with the bottom of the fixed pelleting plate 3. Extrusion then stops. The movable mechanism 4 moves the movable pelleting plate 5 closer to the fixed pelleting plate 3, dividing the strip of drug into multiple segments. Then, the movable mechanism 4 moves the movable pelleting plate 5 along the length of the first pelleting groove 31. With the cooperation of the first pelleting groove 31 and the second pelleting groove 51, the drug divided into multiple segments is rolled into multiple pills. Subsequently, the moving pelleting plate 5 stops abruptly, and under the action of inertia, the pills roll out from between the first pelleting groove 31 and the second pelleting groove 51 and are collected by the collecting mechanism 6. The relative sliding between the moving pelleting plate 5 and the fixed pelleting plate 3 is used to roll the pills, realizing a full rolling and shaping process. This solves the problem that the pills produced by the existing technology are often not round enough, have a rough surface, and are irregular in shape, which not only affects the appearance quality of the product, but may also have an adverse effect on the subsequent drying uniformity, coating consistency and patient experience.

[0046] The second embodiment of this application is as follows: Based on the first embodiment, please refer to Figure 8 ,in, Figure 8 This is a flowchart illustrating the second embodiment of the present invention.

[0047] This invention provides a method for preparing a pharmaceutical composition for treating myocardial ischemia, comprising the following steps: S1: Weigh out the corresponding weight proportions of each medicinal material, stir-fry them, pulverize them, and sieve them to make powder raw materials; S2: Put the powdered raw materials, salt water, vegetable oil and maltodextrin into a mixer and stir to make a thick paste; S3: Prepare the thick paste into a qualified lumps; S4: The dextruded drug ball is placed into the extrusion mechanism 2, which extrudes a long strip of drug that falls between the fixed pelleting plate 3 and the movable pelleting plate 5. S5: After the moving mechanism 4 drives the moving pellet plate 5 to approach the fixed pellet plate 3 and close together, it drives the moving pellet plate 5 to start moving along the length direction of the first pellet groove 31. S6: The long strip of medicine is rolled into multiple spherical pills and collected by the collection mechanism 6; S7: After vacuum drying, the collected pills are packaged.

[0048] In the step of weighing the corresponding proportions of each medicinal material, frying them, pulverizing them, and sieving them to make powdered raw materials: The medicinal materials, by weight, include: 15-25 parts of Panax notoginseng, 15-25 parts of Salvia miltiorrhiza, 20-30 parts of Astragalus membranaceus, 0.5-2 parts of Strychnos nux-vomica, 10-20 parts of Achyranthes bidentata, 5-10 parts of Pueraria lobata, 0.5-2 parts of Calculus bovis, 5-10 parts of Ginkgo biloba, 1-3 parts of Phellodendron chinense, and 1-3 parts of Ilex chinensis.

[0049] The above-disclosed embodiments are merely one or more preferred embodiments of this application and should not be construed as limiting the scope of this application. Those skilled in the art can understand that all or part of the processes for implementing the above embodiments and equivalent changes made in accordance with the claims of this application still fall within the scope of this application.

Claims

1. An apparatus for preparing a pharmaceutical composition for treating myocardial ischemia, characterized in that, Includes mounting base, extrusion mechanism, fixed pelletizing plate, moving mechanism, moving pelletizing plate and collecting mechanism; The extrusion mechanism is located on the top of the mounting base; the fixed pelleting plate is fixedly located on one side of the mounting base; the fixed pelleting plate is provided with a plurality of first pelleting grooves; the moving mechanism is located on one side of the mounting base; the moving pelleting plate is located on the moving mechanism; the moving pelleting plate is provided with a plurality of second pelleting grooves; the moving mechanism can drive the moving pelleting plate to move in a direction perpendicular to the fixed pelleting plate, and can also drive the moving pelleting plate to move along the length direction of the first pelleting grooves; the collecting mechanism is located on one side of the mounting base for collecting the prepared pellets.

2. The apparatus for preparing a pharmaceutical composition for treating myocardial ischemia as described in claim 1, characterized in that, The extrusion mechanism includes an extrusion cylinder, an extrusion head, a first rotating shaft, spiral blades, and a first motor; The extrusion cylinder is fixedly mounted on the top of the mounting base; the extrusion head is fixedly mounted on one side of the extrusion cylinder and communicates with the extrusion cylinder; the first rotating shaft is rotatably mounted inside the extrusion cylinder; the spiral blade is fixedly mounted on the first rotating shaft; the first motor is fixedly mounted on one side of the extrusion cylinder, and the output end of the first motor is fixedly connected to the first rotating shaft.

3. The apparatus for preparing a pharmaceutical composition for treating myocardial ischemia as described in claim 2, characterized in that, The extrusion mechanism also includes a feed hopper; The feed hopper is fixedly disposed at the top of the extrusion cylinder and is in communication with the extrusion cylinder.

4. The apparatus for preparing a pharmaceutical composition for treating myocardial ischemia as described in claim 3, characterized in that, The extrusion mechanism also includes a second rotating shaft, a second motor, and a pressure block; The second rotating shaft is rotatably disposed inside the feed hopper; the second motor is fixedly disposed on one side of the feed hopper, and the output end of the second motor is fixedly connected to the second rotating shaft; the pressure block is fixedly disposed on the second rotating shaft.

5. The apparatus for preparing a pharmaceutical composition for treating myocardial ischemia as described in claim 4, characterized in that, The moving mechanism includes a guide rail, a sliding seat, a first hydraulic cylinder, a bracket, multiple guide rods, and a second hydraulic cylinder; The guide rail is fixedly mounted on one side of the mounting base; the sliding seat is slidably mounted on the guide rail; the first hydraulic cylinder is fixedly mounted on the guide rail, and the output end of the first hydraulic cylinder is fixedly connected to the sliding seat; the bracket is fixedly mounted on the sliding seat; a plurality of guide rods are respectively fixedly connected to the movable pelletizing plate and slidably connected to the bracket, and respectively pass through the bracket; the second hydraulic cylinder is fixedly mounted on the bracket, and the output end of the second hydraulic cylinder is fixedly connected to the movable pelletizing plate.

6. The apparatus for preparing a pharmaceutical composition for treating myocardial ischemia as described in claim 5, characterized in that, The collection mechanism includes multiple inclined guide slides and a collection slide; Multiple inclined guide slides are fixedly installed on one side of the mounting base, and the multiple inclined guide slides are connected to multiple first pelleting grooves in a one-to-one correspondence, for guiding the formed pellets to roll down; the collecting slide is fixedly installed on one side of the mounting base, for catching the pellets that slide down from the multiple inclined guide slides.

7. The apparatus for preparing a pharmaceutical composition for treating myocardial ischemia as described in claim 6, characterized in that, The collection mechanism also includes a collection tray; The collection tray is fixedly installed on one side of the mounting base to catch the pills that roll down from the collection slide.

8. The apparatus for preparing a pharmaceutical composition for treating myocardial ischemia as described in claim 7, characterized in that, The apparatus for preparing the drug composition for treating myocardial ischemia also includes a shunt tube and multiple blowing discs; The diversion pipe is fixedly installed on one side of the movable pelletizing plate; the multiple air blowing discs are respectively connected to one side of the diversion pipe and are connected to the multiple second pelletizing grooves one by one.

9. A method for preparing a pharmaceutical composition for treating myocardial ischemia, comprising using the apparatus for preparing a pharmaceutical composition for treating myocardial ischemia as described in claim 1; characterized in that, The specific steps include: Weigh out the corresponding weight proportions of each medicinal material, stir-fry them, pulverize them, and sieve them to make powdered raw materials; Powdered ingredients, salt water, vegetable oil, and maltodextrin are mixed in a mixer to form a thick paste; The thick paste is made into qualified medicine lumps; The dextrose is placed into the extrusion mechanism, which extrudes long strips of medicine that fall between the fixed pelleting plate and the moving pelleting plate. After the moving mechanism drives the moving pelleting plate to approach and close the fixed pelleting plate, it drives the moving pelleting plate to start moving along the length of the first pelleting groove. The long strips of medicine were rolled into multiple spherical pills and collected by a collection agency; The collected pills are vacuum dried and then packaged.

10. The method for preparing the pharmaceutical composition for treating myocardial ischemia as described in claim 9, characterized in that, In the step of weighing out the corresponding weight proportions of each medicinal material, frying it, pulverizing it, and sieving it to make powdered raw materials: The medicinal materials, by weight, include: 15-25 parts of Panax notoginseng, 15-25 parts of Salvia miltiorrhiza, 20-30 parts of Astragalus membranaceus, 0.5-2 parts of Strychnos nux-vomica, 10-20 parts of Achyranthes bidentata, 5-10 parts of Pueraria lobata, 0.5-2 parts of Calculus bovis, 5-10 parts of Ginkgo biloba, 1-3 parts of Phellodendron chinense, and 1-3 parts of Ilex chinensis.

Images