Micro-current stimulation hydrogel composite mask and preparation method thereof

Abstract

The invention discloses a micro-current stimulation hydrogel composite mask and a preparation method thereof. The composite mask comprises a positive electrode gel mask and a negative electrode gel mask. The positive electrode gel mask comprises a negative electrode gel base material, and a positive electrode electroactive component and a nano conductive material which are dispersed in the positive electrode gel base material. The positive electrode electroactive component adopts Prussian blue and / or nano zinc particles. And the negative electrode gel mask comprises a negative electrode gel base material and a negative electrode electroactive component dispersed in the negative electrode gel base material. And the negative electrode electroactive component adopts magnesium-zinc alloy nanoparticles. The positive electrode gel mask and the negative electrode gel mask provided by the invention can form a metal primary battery, continuously and stably output micro current in a contact area of the mask and the skin, apply continuous and mild skin electrical stimulation, promote blood circulation and cell metabolism of the skin, and achieve beautifying and anti-aging effects.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of hydrogel battery preparation, and particularly relates to a micro-current stimulation hydrogel composite mask and a preparation method thereof. BACKGROUND

[0002] Microcurrent stimulation (MCS) is a non-invasive bioelectric intervention technology that has attracted widespread attention in the fields of medical rehabilitation, neural regulation, wound repair, and skin anti-aging in recent years. The basic principle is to simulate endogenous bioelectric signals in the human body through low-intensity electric current, thereby activating cell membrane potential regulation, promoting ion channel conduction, and ultimately affecting cell energy metabolism and tissue regeneration. Studies have shown that micro-current stimulation can promote ATP (adenosine triphosphate) synthesis, mitochondrial activity, and cell proliferation and migration, which collectively provide an energy basis for tissue repair and skin rejuvenation.

[0003] In the field of skin beauty and anti-aging, micro-current technology exhibits unique advantages. Moderate micro-current can improve skin microcirculation, enhance blood and oxygen supply, increase cell metabolic activity, promote keratinocyte and fibroblast function, stimulate collagen and elastic fiber synthesis, restore the structural integrity of the dermal layer, promote lymphatic return and metabolic waste excretion, thereby reducing edema, fine lines, and wrinkles, and improving muscle tone, making facial contours more firm and three-dimensional.

[0004] Generally, the current range for micro-current stimulation in skin anti-aging is 20-600 μA. Studies have shown that when the stimulation intensity is below 1 mA, the nerves and muscles can be avoided from producing significant contraction responses, and only through cell membrane potential fine-tuning can physiological effects be produced. Current in this range can be obtained through various means, such as: through a precision current control chip to output stable microampere-level current or through a piezoelectric or triboelectric nanogenerator to generate low-amplitude bioelectric signals using human motion or skin contact friction, achieving self-driven micro-current stimulation without external power supply.

[0005] Although micro-current technology has shown significant effects in skin anti-aging, there are still some technical challenges and room for improvement. Firstly, traditional micro-current therapy strongly depends on external electrical equipment, and the use process is limited by power supply and operating conditions; secondly, the efficacy is highly dependent on the good adhesion of the electrode and the skin surface, including contact area, electrode material, biocompatibility, and stable control of interface impedance; thirdly, existing devices still need to be improved in terms of long-term stability, parameter controllability, and electrical safety protection mechanisms.

[0006] Therefore, it is of great significance to develop a new type of micro-current stimulation mask with self-powered characteristics, high skin adhesion and excellent biocompatibility for realizing continuous, safe and precise facial anti-aging intervention. This will provide a new technical path for the intelligent and personalized development of the future medical and cosmetic industry. SUMMARY

[0007] To solve the above technical problems, the purpose of the present application is to provide a hydrogel mask with good biocompatibility, which can realize micro-current stimulation of the skin and has other anti-aging functions, to solve the problem that the mask skin care product cannot stimulate the skin through electrical stimulation to realize the efficacy of skin anti-aging and repair, and to solve the problems of skin adhesion and biological safety of micro-current devices.

[0008] In a first aspect, the present application provides a micro-current stimulation hydrogel composite mask, which comprises a positive electrode gel mask and a negative electrode gel mask.

[0009] The positive electrode gel mask comprises a negative electrode gel substrate, and a positive electrode electroactive component and a nano-conductive material dispersed in the positive electrode gel substrate. The positive electrode electroactive component uses Prussian blue and / or nano-zinc particles.

[0010] The negative electrode gel mask comprises a negative electrode gel substrate, and a negative electrode electroactive component dispersed in the negative electrode gel substrate. The negative electrode electroactive component uses magnesium-zinc alloy nanoparticles.

[0011] The positive electrode gel mask uses one of a smearing type gel mask or an attached type mask. The negative electrode gel mask uses one of a smearing type gel mask or an attached type mask.

[0012] During use, the positive electrode gel mask and the negative electrode gel mask are in contact with the user's face, and the positive electrode gel mask and the negative electrode gel mask are in contact to form a closed loop through the user's face.

[0013] Preferably, the magnesium-zinc alloy nanoparticles have a particle size of 50-150 nm, and further preferably 100 nm; the mass ratio of magnesium to zinc is 1:(0.5-2), and further preferably 1:1. The nano-zinc particles have a particle size of 30-120 nm, and further preferably 80 nm.

[0014] Preferably, the positive electrode gel mask and the negative electrode gel mask both use an attached type mask. The positive electrode gel mask is one of an outer layer mask and an inner layer mask; and the negative electrode gel mask is the other of the outer layer mask and the inner layer mask. During use, the outer layer mask and the inner layer mask are arranged in layers from the outside to the inside on the user's face. The outer layer mask is divided into two regions, namely an ion exchange region aligned with the inner layer mask during use and a micro-current stimulation region offset from the inner layer mask during use.

[0015] As preferred, in the aligned laminated state, the micro-current stimulation zone comprises a peripheral surrounding stimulation zone, a cheek-side stimulation zone and a nasal ala-side stimulation zone.

[0016] As preferred, the positive electrode electroactive component adopts Prussian blue. The positive electrode gel mask serves as an outer layer mask; the negative electrode gel mask serves as an inner layer mask.

[0017] As preferred, the nano-conductive material adopts one or more of graphene, carbon nanotube, polypyrrole, polydioxythiophene.

[0018] As preferred, the magnesium-zinc alloy nanoparticles are coated with a passivation layer on the surface. The material of the passivation layer on the surface of the magnesium-zinc alloy nanoparticles is magnesium oxide or zinc oxide; the thickness of the passivation layer is 2-10 nm.

[0019] As preferred, the positive electrode gel base material comprises a first positive electrode base material component. The negative electrode gel base material comprises a first negative electrode base material component. The first positive electrode base material component and the first negative electrode base material component each adopt any one or more of collagen, hyaluronic acid, gelatin, gelatin methacrylate, polyvinyl alcohol, natural polysaccharide, derivative of natural polysaccharide, polyethylene glycol, derivative of polyethylene glycol, chondroitin sulfate, sodium chondroitin sulfate, polyglutamic acid. The first positive electrode base material component and the second negative electrode base material component can be the same or different.

[0020] As preferred, the molecular weight of the collagen is 90-130 kDa, and the concentration of the collagen solution is 0.5-3 wt%.

[0021] As preferred, the molecular weight of the hyaluronic acid is 200-1500 kDa, and the mass fraction of the hyaluronic acid in the whole reaction system is 0.1-2 wt%.

[0022] The degree of substitution of the methacryl group of the gelatin methacrylate (GelMA) is 50%-90%, and the mass fraction of the GelMA in the aqueous solution is 2-10 wt%.

[0023] As preferred, the weight average molecular weight of the polyvinyl alcohol (PVA) is 30-100 kDa, and further preferably about 70 kDa, and the mass fraction of the PVA in the aqueous solution is 3-15 wt%.

[0024] As preferred, the weight average molecular weight of the gelatin is 50-200 kDa, and the Bloom value is 80-300, and the mass fraction of the gelatin in the aqueous solution is 0.5-10 wt%.

[0025] Preferably, the natural polysaccharide is selected from one or more of sodium alginate or chitosan, wherein: the degree of deacetylation of the chitosan is 70% to 95%, the weight-average molecular weight is 50 to 300 kDa, and its mass fraction in acidic aqueous solution is 0.5 to 3 wt%; the viscosity-average molecular weight of the sodium alginate is 100 to 600 kDa, and its mass fraction in aqueous solution is 0.5 to 5 wt%.

[0026] Preferably, the polyethylene glycol (PEG) or its derivative has a molecular weight of 2 to 20 kDa and a mass fraction of 1 to 10 wt% in aqueous solution.

[0027] Preferably, the chondroitin sulfate or sodium chondroitin sulfate has a molecular weight of 10-50 kDa and a mass fraction of 0.1-2 wt% in aqueous solution.

[0028] Preferably, the polyglutamic acid has a molecular weight of 100-1000 kDa and a mass fraction of 0.5-5 wt% in aqueous solution.

[0029] Preferably, the positive electrode gel substrate further includes a positive electrode polyphenol material co-crosslinked with the first positive electrode substrate component. The negative electrode gel substrate further includes a negative electrode polyphenol material co-crosslinked with the first negative electrode substrate component. The positive electrode polyphenol material and the negative electrode polyphenol material may be the same or different.

[0030] Preferably, the positive electrode polyphenol material and the negative electrode polyphenol material are each selected from one or more of the following: epigallocatechin gallate, proanthocyanidins, ellagic acid, chlorogenic acid, tannic acid, tannic acid ester, gallic acid, ester gallic acid, dopamine, and caffeic acid.

[0031] Preferably, the epigallocatechin gallate (EGCG) has a mass fraction of 0.01 to 0.2 wt% relative to the total mass of the corresponding electrode material in the first positive electrode substrate component and its corresponding positive electrode polyphenol material, or in the first negative electrode substrate component and its corresponding negative electrode polyphenol material.

[0032] Preferably, the proanthocyanidins are used as positive electrode polyphenol materials and / or negative electrode polyphenol materials; the mass fraction of the proanthocyanidins in the positive electrode gel mask or the negative electrode gel mask is 0.05 to 0.5 wt%.

[0033] Preferably, the ellagic acid is used as a positive electrode polyphenol material and / or a negative electrode polyphenol material; the mass fraction of the ellagic acid in the positive electrode gel mask or the negative electrode gel mask is 0.01 to 0.1 wt%.

[0034] Preferably, the chlorogenic acid is used as a positive electrode polyphenol material and / or a negative electrode polyphenol material; the mass fraction of the chlorogenic acid in the positive electrode gel film or the negative electrode gel film is 0.01 to 0.3 wt%.

[0035] Preferably, the tannic acid or its esters are used as positive electrode polyphenol materials and / or negative electrode polyphenol materials; the mass fraction of the tannic acid or its esters in the positive electrode gel film or negative electrode gel film is 0.01-0.5 wt%, more preferably 0.05-0.2 wt%.

[0036] Preferably, the gallic acid or its esters are used as positive electrode polyphenol materials and / or negative electrode polyphenol materials; the mass fraction of the gallic acid or its esters in the positive electrode gel film or negative electrode gel film is 0.01 to 0.3 wt%, more preferably 0.05 to 0.15 wt%.

[0037] Preferably, the dopamine is used as a positive electrode polyphenol material and / or a negative electrode polyphenol material; the mass fraction of the dopamine in the positive electrode gel film or the negative electrode gel film is 0.001 to 0.05 wt%, more preferably 0.005 to 0.02 wt%.

[0038] Preferably, the caffeic acid is used as a positive electrode polyphenol material and / or a negative electrode polyphenol material; the mass fraction of the caffeic acid in the positive electrode gel mask or the negative electrode gel mask is 0.01 to 0.5 wt%, more preferably 0.05 to 0.2 wt%.

[0039] Preferably, both the positive electrode gel mask and the negative electrode gel mask are spreadable gel masks. The viscosity of the spreadable gel is controlled to be between 2800 and 3200 mPa·s.

[0040] Secondly, the present invention provides a method for preparing a microcurrent-stimulated hydrogel composite mask, which is used to prepare the aforementioned microcurrent-stimulated hydrogel composite mask.

[0041] The preparation method includes:

[0042] The positive electrode electroactive component, the first positive electrode substrate component, and the positive electrode polyphenol material are added to the electrolyte system and cross-linked and cured to obtain a positive electrode gel film.

[0043] The negative electrode electroactive component, the first negative electrode substrate component, and the negative electrode polyphenol material are added to the electrolyte system and cross-linked and cured to obtain a negative electrode gel film.

[0044] Preferably, the electrolyte system is a solution of magnesium salt and / or zinc salt.

[0045] Preferably, the corresponding electrolyte system uses any one of magnesium salt electrolyte, zinc salt electrolyte, or a mixed magnesium salt and zinc salt electrolyte; the magnesium salt is selected from one or more of magnesium chloride and magnesium sulfate, and the zinc salt is selected from one or more of zinc sulfate, zinc acetate, zinc lactate, zinc chloride, and zinc citrate; the magnesium salt and zinc salt mixed electrolyte contains Mg 2+ With Zn 2+ The molar ratio is 1:(0.5-2), more preferably 1:1; the magnesium salt-zinc salt mixed electrolyte contains Mg 2+ and Zn 2+ The total concentration is 0.05–0.2 mol / L, more preferably 0.1 mol / L.

[0046] The beneficial effects of this invention are as follows:

[0047] 1. This invention utilizes a magnesium-zinc alloy to prepare the negative electrode mask and a Prussian blue / polypyrrole composite material as the positive electrode mask. Upon contact with the face, these two components form a primary metal battery, continuously and stably outputting a microcurrent in the area where the mask contacts the skin. The electrochemical reaction process of this battery can be maintained under low voltage conditions, ensuring a stable and slow-release microcurrent output during long-term use of the mask. This effectively achieves continuous and gentle electrical stimulation of the skin, promoting blood circulation and cell metabolism, thus achieving cosmetic and anti-aging effects.

[0048] 2. The hydrogel matrix and its constituent materials used in this invention, such as recombinant human collagen and hyaluronic acid, all possess excellent biocompatibility, allowing for good adhesion to the skin surface and ensuring no irritation or side effects. Furthermore, the mask does not rely on an external power source; it utilizes the oxidation reaction between a magnesium-zinc alloy and Prussian blue for energy, avoiding the risks associated with traditional electronic devices and making it safer and more convenient to use.

[0049] 3. Based on the self-adhesive phenolic quinone chemical mechanism, this invention enables the mask to possess long-term stable self-adhesion, ensuring a stable fit on the skin. Simultaneously, polyphenols coat the surface of the magnesium-zinc nanoparticles, preventing nanoparticle aggregation and thus improving the battery discharge stability of the battery-type hydrogel mask, further extending the mask's usage time and enhancing product reliability.

[0050] 4. This invention, through a rationally designed positive and negative electrode gel mask, achieves low-voltage, slow-release electrochemical energy output, providing the skin with approximately 5–30 μA / cm². 2 The microcurrent stimulation corresponds to a total current of 50–300 μA, which is within the range of conventional safe cosmetic microcurrent stimulation (<1 mA). This microcurrent can act evenly on the target area of ​​the face, improve skin microcirculation, promote cell repair and metabolism, achieve anti-aging and repair effects, and has significant skin care effects. Attached Figure Description

[0051] Figure 1 This is a schematic diagram of the adhesive microcurrent-stimulated hydrogel composite mask provided in Embodiment 1 of the present invention.

[0052] Figure 2 This is a schematic diagram of the discharge principle of the adhesive microcurrent-stimulated hydrogel composite mask provided in Embodiment 1 of the present invention.

[0053] Figure 3 This is a schematic diagram of the discharge curve of the adhesive microcurrent-stimulated hydrogel composite mask provided in Embodiment 1 of the present invention.

[0054] Figure 4 The capacity-voltage change curve of the adhesive microcurrent-stimulated hydrogel composite mask provided in Embodiment 1 of the present invention. Detailed Implementation

[0055] The principles and features of the present invention are described below with reference to the accompanying drawings. The examples given are for illustrative purposes only and are not intended to limit the scope of the invention. Unless otherwise specified in the examples, conventional conditions or conditions recommended by the manufacturer should be followed. Reagents or instruments whose manufacturers are not specified are all commercially available products.

[0056] Example 1

[0057] An adhesive microcurrent-stimulated hydrogel composite facial mask comprises an outer layer mask and an inner layer mask that are stored independently. The outer layer mask has a larger area than the inner layer mask and can completely cover the inner layer mask. During use, the outer and inner layers are stacked on the user's face from the outside in and provide microcurrent stimulation.

[0058] Both the outer and inner membranes have eye and mouth perforations, and nasal adaptation grooves. The eye and mouth perforations expose the user's eyes and mouth during use. The nasal adaptation grooves form a nasal patch that can be flipped and moved.

[0059] With the eye and mouth cutout structures aligned in a stacked configuration, the outer contour of the inner membrane is completely within the outer contour of the outer membrane. The outer membrane is divided into two regions: an ion exchange region aligned with the inner membrane during use, and a microcurrent stimulation region offset from the inner membrane during use.

[0060] The negative electrode gel mask has a hollowed-out structure corresponding to the areas on both sides of the nose and cheeks, so that the microcurrent stimulation area includes an outer ring stimulation area, cheek stimulation areas, and nose stimulation areas. The outer ring stimulation area surrounds the outer contour of the face during use.

[0061] In this embodiment, the outer layer film is a positive electrode gel film; the inner layer film is a negative electrode gel film. The positive electrode gel film includes a positive electrode gel matrix, and Prussian blue, graphene, and polyphenol proanthocyanidins dispersed in the positive electrode gel matrix. The positive electrode gel matrix is ​​formed by photocrosslinking and curing with hyaluronic acid.

[0062] The negative electrode gel mask comprises a negative electrode gel matrix, magnesium-zinc alloy nanoparticles, EGCG (epigallocatechin gallate), and type I human recombinant collagen dispersed within the negative electrode gel matrix. The negative electrode gel matrix is ​​formed by polyphenol-assisted cross-linking and curing.

[0063] In some other embodiments, the outer layer film is a negative electrode gel film; the inner layer film is a positive electrode gel film.

[0064] When using a face mask, the inner layer of the mask is applied to the face, and then the outer layer of the mask is applied on top of the inner layer. The microcurrent stimulation area of ​​the outer layer of the mask comes into contact with the face, forming a hydrogel battery mask that can output microcurrents.

[0065] The principle behind the continuous microcurrent output of the adhesive microcurrent-stimulated hydrogel composite mask provided in this embodiment is as follows:

[0066] In this embodiment, the adhesive microcurrent-stimulated hydrogel composite mask uses a magnesium-zinc alloy as the negative electrode and a Bruce Blue / polypyrrole composite material as the positive electrode to form an aqueous hybrid ion primary battery. Its energy output comes from the potential difference formed between the oxidation reaction of the magnesium-zinc alloy and the reversible intercalation-deintercalation reaction of metal ions in the Bruce Blue framework.

[0067] The role of the magnesium-zinc alloy in the negative electrode is as follows: During discharge, a spontaneous oxidation reaction occurs on the negative electrode side. Mg and Zn, as active metals, are the first to lose electrons in the hydrogel substrate, which can be summarized as follows:

[0068] Mg → Mg 2+ + 2e -

[0069] Zn → Zn 2+ + 2e -

[0070] Bruce Blue (PB) in the positive electrode is an open cubic framework metal cyanide coordination compound with the following characteristics: It contains numerous cavities capable of intercalating metal ions, allowing for reversible electron transfer and ion insertion / extraction reactions. During discharge, electrons from the external circuit reach the positive electrode, and the Fe in the PB framework... 3+ / Fe 2+A change in valence state occurs. Simultaneously, Mg... 2+ / Zn 2+ PPY is embedded in the PB structure from the electrolyte to maintain electroneutrality. PPY is not a main reactant in the cathode, but acts as a functional enhancing phase, providing a continuous electron conduction network, reducing the contact resistance between Bruce Blue particles, and improving the discharge stability of the cathode.

[0071] During use, the adhesive microcurrent-stimulated hydrogel composite mask adheres fully to the skin surface. The positive and negative electrode layers inside the mask are ion-connected by magnesium and zinc ions. Due to the continuous ion conduction channels and good water retention of the hydrogel matrix, the electrochemical reaction process can continue under low voltage conditions, thereby forming a stable and slow-release microcurrent output in the area where the mask contacts the skin. This microcurrent is distributed along the skin surface and superficial tissues, achieving continuous and gentle electrical stimulation of the skin without the need for an external power source.

[0072] The main function of polyphenols is to provide the battery-type hydrogel mask with appropriate adhesion to the skin and to ensure the dispersion of nanomaterials. Good adhesion to the skin allows the battery's microcurrent stimulation to be evenly applied to the entire face; ensuring the dispersion of nanomaterials guarantees the stability and uniformity of the battery-type hydrogel mask's discharge.

[0073] The preparation method of the microcurrent-stimulated hydrogel composite mask is as follows:

[0074] Step 1: Preparation of the negative electrode gel mask: Magnesium-zinc alloy nanoparticles (particle size 100 nm, mass ratio 1:1, total content 0.2 wt%, with a 5 nm magnesium oxide passivation layer coated on the surface through ball milling) were added to a polyphenol solution containing 0.05 wt% EGCG (epigallocatechin gallate) and dispersed thoroughly. The dispersion was then added to 1.0 mg / mL of type I human recombinant collagen (molecular weight approximately 110 kDa, concentration 1 wt%) as the hydrogel substrate. After mixing, the mixture was cross-linked and cured with polyphenol oxidative assistance to obtain a negative electrode gel mask with a thickness of 100 μm.

[0075] Step 2: Preparation of positive electrode gel mask: Take hyaluronic acid (molecular weight 800 kDa, concentration 1 wt%), add 0.5 wt% Prussian blue and 0.2 wt% graphene, then add 0.1 wt% polyphenol proanthocyanidins, mix well, and then cure by photocrosslinking (Irgacure 0.05 wt%, 365 nm, 5 minutes) to obtain a positive electrode gel mask with a thickness of about 100 μm.

[0076] Step 3: Store the negative electrode gel mask and the positive electrode gel mask separately until needed. Take them out together, apply the negative electrode gel mask to your face, and then cover it with the positive electrode gel mask. The two masks form a closed micro-electrochemical system through their internal ion conduction network and conductive fillers. This system can generate a low-load, self-powered microcurrent without an external power source, which can be used to promote skin microcirculation and cell metabolism.

[0077] In this embodiment, in both the negative electrode gel mask and the positive electrode gel mask, polyphenols can serve as a surface coating for magnesium-zinc alloy nanoparticles and Prussian blue, covering the surface of the magnesium-zinc nanoparticles or their alloy nanoparticles, preventing nanoparticle aggregation, and prolonging the effect time of the battery-type hydrogel mask on facial skin.

[0078] The discharge performance of the adhesive microcurrent-stimulated hydrogel composite mask provided in this embodiment was tested, and the results are as follows: Figure 3 and Figure 4 As shown. Figure 3 This reflects the voltage decrease over time of the adhesive microcurrent-stimulated hydrogel composite mask provided in this embodiment; its current density within 15 minutes is 0.16 μA·cm. -2 The discharge curves exhibit obvious nonlinear decay characteristics and slope changes during the intermediate discharge stage, indicating that the battery-type hydrogel mask has typical slow-release electrochemical energy output behavior. Figure 4 This reflects the release capacity (area specific capacity) and discharge voltage decay behavior of the adhesive microcurrent-stimulated hydrogel composite mask provided in this embodiment under constant current conditions. Figure 4 As can be seen from the data, the adhesive microcurrent-stimulated hydrogel composite mask provided in this embodiment exhibits continuous and smooth voltage decay characteristics under constant current discharge conditions, achieving a voltage decay of approximately 2.5 μAh·cm⁻¹. -2 It has a high areal specific capacity and a stable electrochemical energy output capability, making it suitable for low-voltage, slow-release bioelectric stimulation applications.

[0079] Example 2

[0080] An adhesive microcurrent-stimulated hydrogel composite mask, the difference between this embodiment and Example 1 is that the preparation method is different.

[0081] The preparation method of this embodiment is used to prepare a battery-type hydrogel mask with low parameter limits, and specifically includes the following steps:

[0082] Step 1: Preparation of negative electrode gel mask: Magnesium-zinc alloy nanoparticles (particle size 50 nm, mass ratio 1:0.5, total content 0.05 wt%, surface coated with 2 nm zinc oxide layer) were dispersed in a polyphenol solution containing 0.01 wt% EGCG. The dispersion was then added to 0.5 mg / mL collagen and mixed well. The mixture was then cross-linked and cured with polyphenol oxidase for 3 minutes to form a negative electrode gel mask with a thickness of 80 μm.

[0083] Step 2: Preparation of positive electrode gel mask: Take hyaluronic acid (molecular weight 200 kDa, concentration 1 wt%), add 0.1 wt% Prussian blue, 0.05 wt% carbon nanotubes, and 0.05 wt% proanthocyanidins, and crosslink with ultraviolet light for 3 minutes to obtain a positive electrode gel mask with a thickness of 80 μm.

[0084] Step 3: Store the negative electrode gel mask and the positive electrode gel mask separately until they are ready to be used. Take them out together, apply the negative electrode gel mask to your face, and cover it with the positive electrode gel mask to form a low-load microcurrent stimulation hydrogel composite mask.

[0085] Example 3

[0086] An adhesive microcurrent-stimulated hydrogel composite mask, the difference between this embodiment and Example 1 is that the preparation method is different.

[0087] The preparation method of this embodiment is used to prepare a battery-type hydrogel mask with long-lasting microcurrent stimulation, and specifically includes the following steps:

[0088] Step 1: Preparation of negative electrode gel mask: Magnesium-zinc alloy nanoparticles (particle size 150 nm, mass ratio 1:2, total content 0.5 wt%, surface coated with 10 nm magnesium oxide layer) were dispersed in a polyphenol solution containing 0.5 wt% proanthocyanidins. Then, GelMA (methacrylamide gelatin, mass fraction 10 wt%, degree of substitution 90%) and 1 mg / mL recombinant collagen were added and mixed. The mixture was then crosslinked with 0.1 wt% Genipin (a biological crosslinking agent) for 4 hours to cure, resulting in a negative electrode gel mask with a thickness of 200 μm.

[0089] Step 2: Preparation of positive electrode gel mask: Take hyaluronic acid (molecular weight 1500 kDa, concentration 2 wt%), add 1 wt% Prussian blue, 0.5 wt% graphene, and 0.05 wt% ellagic acid, and photocrosslink for 5 minutes to obtain a positive electrode gel mask with a thickness of 200 μm.

[0090] Step 3: Store the negative electrode gel mask and the positive electrode gel mask separately until they are ready to be used. Take them out together, apply the negative electrode gel mask to your face, and cover it with the positive electrode gel mask to form a microcurrent stimulation hydrogel composite mask with high microcurrent output.

[0091] Example 4

[0092] An adhesive microcurrent-stimulated hydrogel composite mask, the difference between this embodiment and Example 1 is that the preparation method is different.

[0093] The preparation method of this embodiment includes the following steps:

[0094] Step 1: Preparation of negative electrode gel mask: Magnesium zinc alloy nanoparticles (particle size 100 nm, mass ratio 1:1, total content 0.2 wt%, surface coated with 5 nm zinc oxide layer) were dispersed in EGCG 0.05 wt% polyphenol solution, and then collagen 2 mg / mL was added. After mixing, the mixture was cured by cross-linking with oxidized polyphenol for 2 hours, resulting in a thickness of 120 μm.

[0095] Step 2: Preparation of positive electrode gel mask: Hyaluronic acid 0.5 wt% (molecular weight 500 kDa), Prussian blue 0.3 wt%, graphene 0.2 wt%, proanthocyanidins 0.1 wt%, photocrosslinked for 4 minutes to obtain a positive electrode gel mask with a thickness of 120 μm.

[0096] Step 3: Store the negative electrode gel mask and the positive electrode gel mask separately until they are ready to be used. Then, take them out together, apply the negative electrode gel mask to your face, and cover it with the positive electrode gel mask to form a microcurrent stimulation hydrogel composite mask that can continuously output microcurrents.

[0097] Example 5

[0098] An adhesive microcurrent-stimulated hydrogel composite mask, the difference between this embodiment and Example 1 is that the preparation method is different.

[0099] The preparation method of this embodiment includes the following steps:

[0100] Step 1: Preparation of the negative electrode gel mask: Magnesium-zinc alloy nanoparticles (particle size 20–30 μm, mass ratio Mg:Zn = 90:10) were added to a 0.01 wt% EGCG polyphenol solution and ultrasonically dispersed for 5 minutes to ensure uniform distribution of the nanoparticles. Then, 0.02 wt% graphene oxide (GO) was added as a conductivity-enhancing component and slowly mixed until homogeneous. The resulting composite dispersion was added to a collagen solution (concentration 0.5 mg / mL) and gently stirred until homogeneous. The mixture was then cured for 3 minutes using a polyphenol-assisted cross-linking reaction to form a negative electrode hydrogel film with a thickness of approximately 80 μm. This negative electrode film exhibits good conductivity, biocompatibility, and skin adhesion.

[0101] Step 2: Take hyaluronic acid solution (0.1 wt%, molecular weight about 200 kDa) as the matrix, add zinc nanoparticles (0.05 wt%) as electron acceptor material, add carbon nanotubes (CNTs, 0.05 wt%) to improve the conductivity of the conductive network, and incorporate proanthocyanidins (0.05 wt%) as a natural antioxidant and stabilizer.

[0102] Step 3: Store the negative electrode gel mask and the positive electrode gel mask separately until they are ready to be used. Then, take them out together, apply the negative electrode gel mask to your face, and cover it with the positive electrode gel mask to form a microcurrent stimulation hydrogel composite mask that can continuously output microcurrents.

[0103] Example 5

[0104] A microcurrent-stimulated hydrogel composite mask includes a positive electrode coating gel and a negative electrode coating gel.

[0105] The preparation process of the positive electrode coating gel is as follows:

[0106] 1. Nanoparticle dispersion: Prussian blue powder and graphene (0.05 wt%) were added together to an aqueous solution of epigallocatechin gallate (EGCG) (0.2 wt%) and ultrasonically treated for 30 minutes.

[0107] 2. Polymer composite: Add the dispersion to the hyaluronic acid solution (2 wt% by mass, 1500 kDa by molecular weight) and mix thoroughly.

[0108] 3. Crosslinking: Forms a positive electrode coating gel with a viscosity of approximately 3200 mPa·s.

[0109] The preparation process of the negative electrode coating gel is as follows:

[0110] 1. Nanoparticle dispersion: Magnesium-zinc alloy nanoparticles (particle size 150 nm, mass ratio 1:2) were added to a proanthocyanidin solution (0.5 wt%) and sonicated for 30 minutes.

[0111] 2. Polymer compounding: Add the dispersion to the gelatin solution (concentration 10 wt%, Bloom 300) and mix thoroughly.

[0112] 3. Crosslinking: Forms a negative electrode coating gel with a viscosity of approximately 3200 mPa·s.

[0113] The process of using the topical microcurrent-stimulated hydrogel composite mask is as follows: apply both the positive electrode topical gel and the negative electrode topical gel to the face simultaneously to achieve a microcurrent output of approximately 1.0 mA.

[0114] Example 6

[0115] A microcurrent-stimulated hydrogel composite mask includes a positive electrode coating gel and a negative electrode coating gel.

[0116] The preparation process of the positive electrode coating gel is as follows:

[0117] 1. Prussian blue powder and carbon nanotubes (0.01 wt%) were added together to an EGCG aqueous solution (0.01 wt%) and sonicated for 30 minutes.

[0118] 2. Add hyaluronic acid solution (0.1 wt%, molecular weight 200 kDa) and mix well.

[0119] 3. Crosslinking: Forms a positive electrode coating gel with a viscosity of approximately 2800 mPa·s.

[0120] The preparation process of the negative electrode coating gel is as follows:

[0121] 1. Magnesium-zinc alloy nanoparticles (50 nm in diameter, mass ratio 1:0.5) were added to an anthocyanin aqueous solution (0.05 wt%) and ultrasonically dispersed.

[0122] 2. Add gelatin solution (0.5 wt%, Bloom 80) and mix well.

[0123] 3. Crosslinking: Forms a negative electrode coating gel with a viscosity of approximately 2800 mPa·s.

[0124] The process of using the topical microcurrent-stimulated hydrogel composite mask is as follows: apply both the positive electrode topical gel and the negative electrode topical gel to the face simultaneously to achieve a microcurrent output of approximately 0.5 mA.

[0125] Example 7

[0126] A microcurrent-stimulated hydrogel composite mask includes a positive electrode coating gel and a negative electrode coating gel.

[0127] The preparation process of the positive electrode coating gel is as follows:

[0128] 1. Prussian blue powder and graphene (0.03 wt%) were added together to EGCG solution (0.1 wt%) and sonicated for 30 minutes.

[0129] 2. Add hyaluronic acid solution (1 wt% by mass, 500 kDa by molecular weight) and mix well.

[0130] 3. Crosslinking: Forms a positive electrode coating gel with a viscosity of approximately 3000 mPa·s.

[0131] The preparation process of the negative electrode coating gel is as follows:

[0132] 1. Magnesium-zinc alloy nanoparticles (particle size 100 nm, mass ratio 1:1) were added to a proanthocyanidin aqueous solution (0.2 wt%) and ultrasonically dispersed.

[0133] 2. Add gelatin solution (5 wt%, Bloom 200) and mix well.

[0134] 3. Crosslinking: Forms a negative electrode coating gel with a viscosity of approximately 3000 mPa·s.

[0135] The process of using the coating-type microcurrent-stimulated hydrogel composite mask is as follows: apply the positive electrode coating gel and the negative electrode coating gel to the face at the same time to achieve a microcurrent output of about 0.8 mA.

[0136] Example 8

[0137] A microcurrent-stimulated hydrogel composite mask includes a positive electrode coating gel and a negative electrode coating gel.

[0138] The preparation process of the positive electrode coating gel is as follows:

[0139] 1. Prussian blue powder and carbon nanotubes (0.02 wt%) were added together to EGCG solution (0.05 wt%) and sonicated for 30 minutes.

[0140] 2. Add hyaluronic acid solution (0.5 wt% by mass, 1000 kDa by molecular weight) and mix well.

[0141] 3. Crosslinking: Forms a positive electrode coating gel with a viscosity of approximately 3000 mPa·s.

[0142] The preparation process of the negative electrode coating gel is as follows:

[0143] 1. Magnesium-zinc alloy nanoparticles (80 nm in diameter, mass ratio 1:1.5) were added to a proanthocyanidin aqueous solution (0.1 wt%) and ultrasonically dispersed.

[0144] 2. Add gelatin solution (3 wt%, Bloom 150) and mix well.

[0145] 3. Crosslinking: Forms a negative electrode coating gel with a viscosity of approximately 3000 mPa·s.

[0146] How to use: Apply the positive and negative electrode gels to the face simultaneously to achieve a microcurrent output of approximately 0.7–0.8 mA.

Claims

1. A microcurrent-stimulated hydrogel composite facial mask, characterized in that: Including positive electrode gel masks and negative electrode gel masks; The positive electrode gel film includes a negative electrode gel substrate, and positive electrode electroactive components and nano-conductive materials dispersed in the positive electrode gel substrate; the positive electrode electroactive components are Prussian blue and / or nano-zinc particles; The negative electrode gel mask includes a negative electrode gel substrate and a negative electrode electroactive component dispersed in the negative electrode gel substrate; the negative electrode electroactive component is a magnesium-zinc alloy nanoparticle. The positive electrode gel mask is either a spreadable gel mask or an adhesive mask; the negative electrode gel mask is either a spreadable gel mask or an adhesive mask.

2. The microcurrent-stimulated hydrogel composite mask according to claim 1, characterized in that: The magnesium-zinc alloy nanoparticles have a particle size of 50–150 nm; the mass ratio of magnesium to zinc is 1:(0.5–2); and the nano-zinc particles have a particle size of 30–120 nm.

3. The microcurrent-stimulated hydrogel composite mask according to claim 1, characterized in that: Both the positive and negative electrode gel masks are adhesive masks; the positive electrode gel mask is one of the outer and inner layers; the negative electrode gel mask is the other of the outer and inner layers; during use, the outer and inner layers are layered on the user's face from the outside to the inside; the outer layer is divided into two areas, namely an ion exchange area aligned with the inner layer during use, and a microcurrent stimulation area offset from the inner layer during use.

4. The microcurrent-stimulated hydrogel composite mask according to claim 3, characterized in that: In the aligned, stacked state, the microcurrent stimulation area includes an outer surrounding stimulation area, stimulation areas on both sides of the cheeks, and stimulation areas on both sides of the nose.

5. The microcurrent-stimulated hydrogel composite mask according to claim 3, characterized in that: The positive electrode electroactive component is Prussian blue; the positive electrode gel film serves as the outer layer film; and the negative electrode gel film serves as the inner layer film.

6. The microcurrent-stimulated hydrogel composite mask according to claim 1, characterized in that: The nano-conductive material is one or more of graphene, carbon nanotubes, polypyrrole, and polydioxyethylthiophene.

7. The microcurrent-stimulated hydrogel composite mask according to claim 1, characterized in that: The magnesium-zinc alloy nanoparticles are coated with a passivation layer; the passivation layer on the surface of the magnesium-zinc nanoparticles is made of magnesium oxide or zinc oxide; the thickness of the passivation layer is 2–10 nm.

8. The microcurrent-stimulated hydrogel composite mask according to claim 1, characterized in that: The positive electrode gel substrate includes a first positive electrode substrate component; the negative electrode gel substrate includes a first negative electrode substrate component; the first positive electrode substrate component and the first negative electrode substrate component each adopt any one or more of the following: collagen, hyaluronic acid, gelatin, gelatin methacrylamide, polyvinyl alcohol, natural polysaccharide, derivatives of natural polysaccharide, polyethylene glycol, derivatives of polyethylene glycol, chondroitin sulfate, sodium chondroitin sulfate, and polyglutamic acid.

9. The microcurrent-stimulated hydrogel composite mask according to claim 8, characterized in that: The collagen has a molecular weight of 90 kDa to 130 kDa; the hyaluronic acid has a molecular weight of 200 kDa to 1500 kDa; the methacryloyl group of the gelatin methacrylamide has a degree of substitution of 50% to 90%; the polyvinyl alcohol has a weight-average molecular weight of 30 kDa to 100 kDa; the gelatin has a weight-average molecular weight of 50 kDa to 200 kDa; the natural polysaccharide is selected from one or more of sodium alginate or chitosan; the chitosan has a degree of deacetylation of 70% to 95% and a weight-average molecular weight of 50 kDa to 300 kDa; the sodium alginate has a viscosity-average molecular weight of 100 kDa to 600 kDa; the polyethylene glycol or its derivatives have a molecular weight of 2 kDa to 20 kDa; the chondroitin sulfate or sodium chondroitin sulfate has a molecular weight of 10 kDa to 50 kDa; and the polyglutamic acid has a molecular weight of 100 kDa to 1000 kDa.

10. A microcurrent-stimulated hydrogel composite mask according to claim 8, characterized in that: The positive electrode gel substrate further includes a positive electrode polyphenol material that is co-crosslinked with the first positive electrode substrate component; the negative electrode gel substrate further includes a negative electrode polyphenol material that is co-crosslinked with the first negative electrode substrate component.

11. The microcurrent-stimulated hydrogel composite mask according to claim 10, characterized in that: The positive electrode polyphenol material and the negative electrode polyphenol material each adopt one or more of the following: epigallocatechin gallate, proanthocyanidins, ellagic acid, chlorogenic acid, tannic acid, tannic acid ester, gallic acid, ester gallic acid, dopamine, and caffeic acid.

12. The microcurrent-stimulated hydrogel composite mask according to claim 1, characterized in that: Both the positive electrode gel mask and the negative electrode gel mask are applied gel masks; the viscosity of the applied gel is controlled to be between 2800 and 3200 mPa·s by controlling the degree of cross-linking.

13. A method for preparing a microcurrent-stimulated hydrogel composite facial mask, characterized in that: Used to prepare a microcurrent-stimulated hydrogel composite mask as described in claim 10; The preparation method includes: The positive electrode electroactive component, the first positive electrode substrate component, and the positive electrode polyphenol material are added to the electrolyte system and cross-linked and cured to obtain a positive electrode gel film. The negative electrode electroactive component, the first negative electrode substrate component, and the negative electrode polyphenol material are added to the electrolyte system and cross-linked and cured to obtain a negative electrode gel film.

14. The preparation method according to claim 13, characterized in that: The electrolyte system uses any one of magnesium salt electrolyte, zinc salt electrolyte, or a mixed magnesium salt and zinc salt electrolyte; the magnesium salt is selected from one or more of magnesium chloride and magnesium sulfate, and the zinc salt is selected from one or more of zinc sulfate, zinc acetate, zinc lactate, zinc chloride, and zinc citrate; the magnesium salt and zinc salt mixed electrolyte contains Mg 2+ With Zn 2+ The molar ratio is 1:(0.5~2); the magnesium salt and zinc salt mixed electrolyte contains Mg 2+ and Zn 2+ The total concentration is 0.05–0.2 mol / L.

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