Sample processing system

Abstract

The invention relates to a sample processing system. The sample treatment system comprises a filter sleeve column, a cover opening and closing module, an overturning module, a centrifugal transfer module, a filter module and a carrying mechanism, the cover opening and closing module is used for configuring the filter sleeve column for an opening of a test tube loaded with a sample; the overturning module is used for overturning the test tube provided with the filter sleeve column; the centrifugal transfer module is used for centrifuging the overturned sample in the filter sleeve column; the filtering module is used for filtering a sample in the filtering sleeve column; and the carrying mechanism is used for carrying the test tubes and / or the filter sleeve columns among the cover opening and closing module, the overturning module, the centrifugal transfer module and the filter module. According to the scheme provided by the invention, the filtering efficiency can be improved, sample residues in the test tube are reduced, and sample waste is reduced.

Description

Technical Field

[0001] This application relates to the field of automated equipment technology, and more particularly to sample processing systems. Background Technology

[0002] In biochemical experiments, after pretreatment operations such as dissolution, extraction, and preparation, samples often require post-processing operations such as filtration, detection, and analysis. In practice, prepared samples are usually stored in test tubes. When filtering the sample, it is necessary to first aspirate it from the test tube and then transfer it into the filter column of the filtration device. This operation is not only inefficient but also makes it difficult to completely transfer the sample, resulting in some sample remaining in the test tube and wasting it. Summary of the Invention

[0003] To address or partially address the problems existing in related technologies, this application provides a sample processing system that can improve filtration efficiency and reduce sample waste.

[0004] This application provides a sample processing system comprising a filter sleeve, a switch cap module, a flipping module, a centrifugation transfer module, a filtering module, and a transport mechanism; the switch cap module is used to configure the filter sleeve at the opening of a test tube containing a sample; the flipping module is used to flip the test tube containing the filter sleeve; the centrifugation transfer module is used to centrifuge the sample in the flipped filter sleeve; the filtering module is used to filter the sample in the filter sleeve; and the transport mechanism is used to transport the test tube and / or the filter sleeve between the switch cap module, the flipping module, the centrifugation transfer module, and the filtering module.

[0005] Furthermore, the sample processing system also includes a first liquid addition module, which is used to add a first target liquid to the test tube containing the sample;

[0006] The first liquid addition module includes a liquid addition needle, a mounting base, a liquid addition moving mechanism, a first control valve, and a first drive pump; the mounting base is connected to the liquid addition moving mechanism and the liquid addition needle respectively, and the liquid addition moving mechanism is used to drive the mounting base to move, thereby driving the liquid addition needle to move; the first control valve is connected to the solvent bottle, the liquid addition needle, and the first drive pump respectively, and the liquid addition needle is used to inject the first target liquid in the solvent bottle into the test tube containing the sample; the transport mechanism is used to transfer the test tube after liquid addition is completed to the switch cap module.

[0007] Furthermore, the sample processing system also includes a mixing module for mixing a test tube containing the sample and the first target liquid;

[0008] The mixing module includes an oscillation mechanism and an oscillation clamping mechanism. The oscillation clamping mechanism is connected to the oscillation mechanism and is used to clamp the test tube. The oscillation mechanism is used to drive the oscillation clamping mechanism to vibrate, thereby causing the test tube to shake. The transport mechanism is used to transfer the test tube equipped with the filter sleeve column to the mixing module, and after mixing is completed, it is transferred to the flipping module.

[0009] Furthermore, the sample processing system also includes a nitrogen blowing module, which is used to perform nitrogen blowing treatment on the sample in the test tube;

[0010] The nitrogen blowing module includes a first lifting mechanism, a nitrogen blowing needle, a connecting seat, a first translation mechanism, a bracket, and a heating component. The nitrogen blowing needle is fixedly mounted on the connecting seat, which has an air passage that connects the nitrogen blowing needle and a nitrogen source. The first lifting mechanism is connected to the connecting seat and drives the connecting seat to rise and fall, thereby raising and lowering the nitrogen blowing needle. The bracket is mounted on the first translation mechanism and located below the nitrogen blowing needle. The bracket is used to hold test tubes, and the first translation mechanism drives the bracket to move closer to or away from the nitrogen blowing needle. The heating component is mounted on the first translation mechanism and heats the test tubes on the bracket.

[0011] Further, the transport mechanism includes a first moving mechanism, a second moving mechanism, a third moving mechanism, and a transport clamping assembly; the second moving mechanism is disposed on the first moving mechanism, and the first moving mechanism is used to drive the second moving mechanism to move along a first direction; the third moving mechanism is disposed on the second moving mechanism, and the second moving mechanism is used to drive the third moving mechanism to move along a second direction; the transport clamping assembly is disposed on the third moving mechanism, and the third moving mechanism is used to drive the transport clamping assembly to move along a third direction; wherein, the first direction, the second direction, and the third direction are mutually perpendicular, and the transport clamping assembly is used to clamp test tubes and / or filter sleeves.

[0012] Furthermore, the transport clamping assembly includes at least two grippers spaced apart along the length direction of the third moving mechanism, wherein at least one of the grippers is fixedly connected to the third moving mechanism along the length direction of the third moving mechanism, and the remaining grippers are movably connected to the third moving mechanism along the length direction of the third moving mechanism.

[0013] Furthermore, the switch cap module includes a cap clamping mechanism and a bottle body clamping mechanism located below the cap clamping mechanism. The bottle body clamping mechanism is used to clamp the test tube, and the cap clamping mechanism is used to clamp the cap or filter sleeve.

[0014] The bottle cap clamping mechanism includes a lifting component, a rotating component, and a first clamping member. The lifting component is connected to the rotating component, and the rotating component is connected to the first clamping member. The first clamping member is used to clamp a bottle cap or filter sleeve column. The rotating component is used to drive the first clamping member to rotate. The lifting component is used to drive the rotating component to move up and down so that the first clamping member is closer to or further away from the test tube.

[0015] The bottle clamping mechanism includes a translation component, a support base, a second clamping member, and a sleeve placement position. The support base is disposed on the translation component, and the second clamping member and the sleeve placement position are disposed on the support base. The second clamping member is used to clamp the test tube, and the sleeve placement position is used to place the filter sleeve. The translation component is used to move the second clamping member or the sleeve placement position to below the first clamping member. The first clamping member is used to clamp the filter sleeve and position the filter sleeve at the opening of the test tube.

[0016] Furthermore, the centrifugal transfer module includes a horizontal rotor, multiple baskets, and a centrifugal rotation mechanism; the centrifugal rotation mechanism is connected to the horizontal rotor and is used to drive the horizontal rotor to rotate; the multiple baskets are evenly arranged on the horizontal rotor and are used to place test tubes.

[0017] The horizontal rotor includes a square base plate and two support rods disposed at each apex of the base plate. The two support rods at each apex extend outward along two sides of the base plate. The basket is disposed between two parallel support rods at two adjacent apex, or the basket is disposed between two support rods at any apex.

[0018] Furthermore, the sample processing system also includes a barcode scanning module, which includes a barcode scanner, a test tube holder, and a barcode scanning rotation mechanism. The test tube holder is used to hold test tubes, the barcode scanning rotation mechanism is connected to the test tube holder, the barcode scanning rotation mechanism is used to drive the test tube holder to rotate, and the barcode scanner is used to scan the test tubes.

[0019] Further, the test tube holder includes a first test tube holder and a second test tube holder; the scanning and rotating mechanism includes a drive motor, a first gear, and a second gear, wherein the first test tube holder is fixedly connected to the first gear, the second test tube holder is fixedly connected to the second gear, the first gear and the second gear mesh, the drive motor is drivenly connected to the first gear or the second gear, and the drive motor is used to drive the first gear or the second gear to rotate, thereby driving the first test tube holder and the second test tube holder to rotate; or

[0020] The scanning and rotating mechanism includes a drive motor, a first synchronous pulley, a second synchronous pulley, and a synchronous belt. The first test tube holder is fixedly connected to the first synchronous pulley, and the second test tube holder is fixedly connected to the second synchronous pulley. The synchronous belt is wound around the first synchronous pulley and the second synchronous pulley. The drive motor is drivenly connected to the first synchronous pulley or the second synchronous pulley. The drive motor is used to drive the first synchronous pulley or the second synchronous pulley to rotate, thereby driving the first test tube holder and the second test tube holder to rotate.

[0021] Furthermore, the sample processing system also includes a loading and unloading module for placing test tubes and / or filter columns;

[0022] The loading and unloading module is provided with multiple material placement positions, each of which is provided with a positioning mechanism and / or a sensing mechanism. The positioning mechanism is used to position the tray carrying the test tubes and / or filter columns, and the sensing mechanism is used to sense the usage status of the material placement position. The positioning mechanism includes at least one of a positioning pin, a limiting strip, and a magnetic suction component.

[0023] Furthermore, the filter sleeve includes a first tube, a second tube, and a connector. The first tube is connected to the second tube. The first tube has a first opening at the end away from the second tube, and the second tube has a second opening at the end away from the first tube. The connector is located at the end of the first tube near the first opening. The connector is used to connect the first tube to a test tube containing a sample. The connector has a liquid flow channel for connecting the first tube and the test tube.

[0024] The inner diameter of the first tube is larger than the inner diameter of the second tube.

[0025] Furthermore, the liquid flow channel includes a first liquid flow channel and a second liquid flow channel that are connected to each other. The first liquid flow channel is closer to the test tube side, and the second liquid flow channel is closer to the first tube body side. The inner diameter of the first liquid flow channel is larger than the inner diameter of the second liquid flow channel.

[0026] The axes of the first liquid flow channel, the second liquid flow channel, the first tube body, and the second tube body are all collinear.

[0027] Furthermore, the connector is interference-fitted to the test tube; or

[0028] The inner wall of the end of the connector that is connected to the test tube is provided with an internal thread, and the outer wall of the test tube near the opening is provided with an external thread. The internal thread and the external thread are engaged to allow the filter sleeve to be positioned at the opening of the test tube.

[0029] Furthermore, the filter sleeve also includes a plug, which is detachably connected to the end of the second tube away from the first tube. The plug is used to seal the second opening before filtration.

[0030] Furthermore, the filter sleeve also includes a filter element located inside the first tube and near one end of the second tube, the filter element being used to filter the sample inside the first tube.

[0031] Furthermore, the filter module includes a support frame and a filter module, the filter module being disposed on the support frame; wherein, the filter module includes a filter gripper assembly and a pressure regulating mechanism;

[0032] The filter gripper assembly includes a first drive mechanism and a filter gripper drivenly connected to the first drive mechanism. The first drive mechanism is disposed on the support frame and is used to drive the filter gripper to clamp the filter sleeve column.

[0033] The pressure regulating mechanism is used to connect to the filter sleeve column and adjust the air pressure inside the filter sleeve column to filter the sample inside the filter sleeve column.

[0034] Furthermore, the filter module also includes an adapter, which is disposed on the support frame and located above the filter gripper. One end of the adapter is connected to the pressure regulating mechanism, and the other end of the adapter is used for a sealed connection with the filter sleeve column.

[0035] The adapter has a first channel for connecting the filter sleeve and the pressure regulating mechanism.

[0036] Furthermore, the pressure regulating mechanism includes a positive pressure component and a pressure relief component; one end of the pressure relief component is connected to the first channel and the other end is connected to the atmospheric environment, and the pressure relief component is used to relieve pressure on the filter sleeve when the adapter is connected to the filter sleeve; one end of the positive pressure component is connected to the first channel and the other end is connected to the air source, and the positive pressure component is used to pressurize the filter sleeve.

[0037] Furthermore, the pressure regulating mechanism also includes a negative pressure component connected to the first channel, the negative pressure component being used to create a negative pressure inside the filter sleeve column.

[0038] Furthermore, the filter module also includes a second liquid addition module, one end of which is connected to a solvent bottle and the other end of which is connected to the adapter. The second liquid addition module is used to deliver a second target liquid into the filter sleeve column.

[0039] The adapter also has a second channel for connecting the filter sleeve column and the second liquid addition module.

[0040] Furthermore, the filter module also includes a second lifting mechanism, which is disposed on the support frame. The filter module is drivenly connected to the second lifting mechanism, which is used to drive the filter module to lift; and / or

[0041] The filter module also includes a third lifting mechanism, which is disposed on the support frame. The adapter is driven to connect with the third lifting mechanism, and the third lifting mechanism is used to drive the adapter to move closer to or away from the filter gripper.

[0042] Furthermore, the filtration module also includes a base and a placement rack located on the base, the placement rack having at least one first placement position for placing a collection bottle;

[0043] The filtration module further includes a second translation mechanism and / or a third translation mechanism. The base is disposed on the second translation mechanism, which drives the base to move along a fourth direction so that the collection bottle on the placement rack moves closer to or away from the filter gripper. The third translation mechanism is disposed on the support frame and connected to the filtration module. The third translation mechanism drives the filtration module to move along a fifth direction so that the filter gripper moves closer to or away from the collection bottle. The fourth direction is parallel or perpendicular to the fifth direction.

[0044] Furthermore, the filter module also includes a fixing clamping assembly disposed on the base;

[0045] The fixed clamping assembly includes a second driving mechanism and a fixed clamping claw driven by the second driving mechanism. The second driving mechanism is used to drive the fixed clamping claw to clamp the filter sleeve column. The fixed clamping claw cooperates with the filter clamping claw or the conveying mechanism to detach the test tube and the connector from the first tube body.

[0046] Furthermore, the filter sleeve also includes a plug, which is detachably connected to the end of the second tube away from the first tube. The plug is used to seal the second opening before filtration.

[0047] The filter module also includes an unloading component located below the filter gripper, which is used to separate the plug from the second tube body.

[0048] Furthermore, the placement rack is also provided with at least one second placement position for placing the filter head; after the unloading component removes the plug, the filter gripper drives the filter sleeve to grab the filter head.

[0049] Furthermore, the filtering module also includes a recycling component disposed on the base, and the unloading component is located above the recycling component;

[0050] The filtering module also includes a detector disposed on the base, the detector being used to detect whether the filter sleeve has pierced the filter head.

[0051] Furthermore, the sample processing system also includes a marking machine for marking the collection bottle and / or the test tube.

[0052] The technical solution provided in this application can include the following beneficial effects: by setting a switch cap module to configure the filter sleeve column in the test tube, and then flipping the test tube with the filter sleeve column in the flipping module, the process of aspirating the sample from the test tube and transferring it into the filter sleeve column is reduced, thereby improving filtration efficiency; by centrifuging the sample through the centrifugation transfer module, all the sample in the test tube enters the filter sleeve column, reducing sample residue in the test tube and avoiding sample waste; by filtering the sample in the filter sleeve column through the filtration module, the filtration operation is automated, which not only reduces the workload of the experimental personnel, but also improves the filtration efficiency.

[0053] It should be understood that the above general description and the following detailed description are exemplary and explanatory only, and do not limit this application. Attached Figure Description

[0054] The above and other objects, features and advantages of this application will become more apparent from the more detailed description of exemplary embodiments thereof in conjunction with the accompanying drawings, wherein the same reference numerals generally represent the same components in the exemplary embodiments thereof.

[0055] Figure 1 This is a schematic diagram of the sample processing system shown in the embodiments of this application;

[0056] Figure 2 This is a schematic diagram of the structure of the switch cover module shown in the embodiment of this application;

[0057] Figure 3 This is a schematic diagram of the structure of the flip module shown in the embodiment of this application;

[0058] Figure 4 This is a schematic diagram of the centrifugal transfer module shown in an embodiment of this application;

[0059] Figure 5 This is a schematic diagram of the structure of the first liquid addition module shown in the embodiment of this application;

[0060] Figure 6 This is a schematic diagram of the mixing module shown in the embodiments of this application;

[0061] Figure 7 This is a schematic diagram of the structure of the nitrogen blowing module shown in the embodiments of this application;

[0062] Figure 8 This is a schematic diagram of the conveying mechanism shown in the embodiments of this application;

[0063] Figure 9 This is a schematic diagram of the structure of the transport clamping assembly shown in the embodiments of this application;

[0064] Figure 10 This is a schematic diagram of the structure of the barcode scanning module shown in the embodiments of this application;

[0065] Figure 11 This is a schematic diagram of the structure of the filter sleeve column after removing the connector, as shown in an embodiment of this application;

[0066] Figure 12 This is a cross-sectional view of the filter sleeve column after the connector has been removed, as shown in an embodiment of this application;

[0067] Figure 13 This is a schematic diagram showing the connection between the filter sleeve column and the test tube in an embodiment of this application;

[0068] Figure 14 yes Figure 13 A sectional view;

[0069] Figure 15 This is a schematic diagram of the structure of the filtering module shown in the embodiments of this application;

[0070] Figure 16 This is a schematic diagram of the structure of the filter module shown in the embodiments of this application;

[0071] Figure 17 This is a schematic diagram of the structure of the placement rack shown in the embodiments of this application;

[0072] Figure 18 This is a structural block diagram of the pressure regulating mechanism shown in the embodiments of this application;

[0073] Figure 19 This is a plan view of the sample processing system shown in the embodiments of this application.

[0074] Reference numerals: Filter sleeve 1; First tube 11; First opening 111; Second tube 12; Second opening 121; Connector 13; First liquid flow channel 131; Second liquid flow channel 132; Plug 14; Switch cap module 2; Base 21; Bottle cap recycling component 211; Bottle cap clamping mechanism 22; Lifting assembly 221; Rotating assembly 222; First clamping component 223; Bottle body clamping mechanism 23; Translation assembly 231; Support base 232; Second clamping component 233; Sleeve placement position 234; Flip module 3; Flip motor 31; Flip clamping component 3 2; Centrifugal transfer module 4; Horizontal rotor 41; Base plate 411; Support rod 412; Basket 42; Filter module 5; Support frame 51; Filter module 52; First drive mechanism 521; Filter gripper 522; Adapter 523; Third lifting mechanism 524; First switching valve 525; Second switching valve 526; Proportional valve 527; Digital display 529; Second lifting mechanism 53; Base 54; Placement rack 55; First placement position 551; Second placement position 552; Second translation mechanism 56; Third translation mechanism 57; Fixed clamping assembly 58; Second Drive mechanism 581; Fixed gripper 582; Recycling assembly 59; Consumable recycling bin 591; Waste liquid pool 592; Buffer box 593; Unloading component 501; Detector 502; Collection bottle 503; Filter head 504; Transport mechanism 6; First moving mechanism 61; Second moving mechanism 62; Third moving mechanism 63; Transport clamping assembly 64; Mounting plate 641; Adjustment mechanism 65; Base frame 66; First liquid addition module 7; Liquid addition needle 71; Mounting base 72; Liquid addition moving mechanism 73; Cleaning pool 74; Mixing module 8; Vibration mechanism 81; Vibration clamping machine Structure 82; Mixing support 83; Mixing guide rail 831; Nitrogen blowing module 9; First lifting mechanism 91; Nitrogen blowing needle 92; Connecting seat 93; First translation mechanism 94; Bracket 95; Heating component 96; Air extraction pipe 97; Scanning module 10; Scanner 101; First test tube holder 102; Second test tube holder 103; Drive motor 104; First gear 105; Second gear 106; Test tube 100; Loading and unloading module 200; Marking machine 300; Workbench 400; Transfer module 500; Robotic arm 600; Material rack 700; Atmospheric environment 800. Detailed Implementation

[0075] Embodiments of this application will now be described in more detail with reference to the accompanying drawings. While embodiments of this application are shown in the drawings, it should be understood that this application may be implemented in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided to make this application more thorough and complete, and to fully convey the scope of this application to those skilled in the art.

[0076] It should be understood that although the terms "first," "second," "third," etc., may be used in this application to describe various information, this information should not be limited to these terms. These terms are only used to distinguish information of the same type from one another. For example, without departing from the scope of this application, first information may also be referred to as second information, and similarly, second information may also be referred to as first information. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this application, "multiple" means two or more, unless otherwise explicitly specified.

[0077] In the description of this application, it should be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application.

[0078] Unless otherwise expressly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0079] To address the aforementioned issues, this application provides a sample processing system that can improve filtration efficiency and reduce sample waste.

[0080] The technical solutions of the embodiments of this application are described in detail below with reference to the accompanying drawings.

[0081] See Figure 1 and Figure 19The sample processing system includes a filter sleeve 1, a cap-opening module 2, a flipping module 3, a centrifugation transfer module 4, a filter module 5, and a transport mechanism 6. The cap-opening module 2 is used to configure the filter sleeve 1 at the opening of the test tube 100 containing the sample. In one embodiment, to facilitate the configuration of the filter sleeve 1 at the opening of the test tube 100, the cap-opening module 2 can store several filter sleeves 1; in another embodiment, a mounting rack can be configured near the cap-opening module 2 to store the filter sleeves 1. When it is necessary to configure the filter sleeve 1 at the opening of the test tube 100, the filter sleeve 1 is transferred from the mounting rack to the cap-opening module 2. It is understood that if the test tube 100 is initially capped, the cap-opening module 2 first opens the cap of the test tube 100 before configuring the filter sleeve 1. One or more cap-opening modules 2 can be configured; when multiple modules are configured, multiple test tubes 100 can be configured with filter sleeves 1 simultaneously, thereby increasing experimental throughput. Among them, the cover switch module 2, the flip module 3, the centrifugal transfer module 4, and the filter module 5 can be set on the workbench 400.

[0082] See Figure 1 , Figure 3 and Figure 19 The flipping module 3 is used to flip the test tube 100 equipped with the filter sleeve 1. The flipping module 3 includes a flipping motor 31 and a flipping clamp 32. The flipping motor 31 and the flipping clamp 32 are connected. The flipping motor 31 can drive the flipping clamp 32 to rotate 180 degrees, and the flipping clamp 32 can clamp and fix the test tube 100. Before the filter sleeve 1 is installed on the test tube 100, the opening of the test tube 100 faces upward and the sample is at the bottom of the test tube 100. When the filter sleeve 1 is installed on the test tube 100, the filter sleeve 1 is installed at the top of the test tube 100. The conveying mechanism 6 sends the test tube 100 equipped with the filter sleeve 1 to the flipping module 3. The flipping module 3 flips the test tube 100 equipped with the filter sleeve 1 by 180 degrees, so that the filter sleeve 1 is below the test tube 100. At this time, the sample in the test tube 100 falls into the filter sleeve 1. In one example, the flipping clamp 32 includes two parallel clamping rods, both of which are driven and connected to a flipping motor 31. The flipping motor 31 can also drive the two clamping rods to move closer or further apart to clamp or release the test tube 100. Each clamping rod has a clamping groove on its opposite side, and the clamping grooves of the two clamping rods cooperate to clamp the test tube 100. The clamping grooves can be arc-shaped, V-shaped, U-shaped, etc., and are not limited here. Multiple clamping grooves can be provided on each clamping rod, enabling simultaneous clamping and flipping of multiple test tubes 100, thereby improving experimental throughput.

[0083] See Figure 1 and Figure 4The centrifugation transfer module 4 is used to centrifuge the sample inside the inverted filter column 1. The filtration module 5 is used to filter the sample inside the filter column 1. That is, the sample inside the filter column 1 is centrifuged and then filtered by the filtration module 5. The transport mechanism 6 can transport test tubes 100 or filter columns 1 between the cover switch module 2, the inverting module 3, the centrifugation transfer module 4, and the filtration module 5, and can also transport test tubes 100 equipped with filter columns 1 between the cover switch module 2, the inverting module 3, the centrifugation transfer module 4, and the filtration module 5. After the cover switch module 2 configures the filter sleeve column 1 on the test tube 100, the transport mechanism 6 can transfer the test tube 100 with the filter sleeve column 1 to the flip module 3. The flip module 3 then flips the test tube 100 with the filter sleeve column 1 up and down, so that the sample in the test tube 100 enters the filter sleeve column 1. The transport mechanism 6 then transfers the flipped test tube 100 and the filter sleeve column 1 to the centrifugation transfer module 4. The centrifugation transfer module 4 centrifuges the sample in the filter sleeve column 1 to transfer as much of the sample in the test tube 100 as possible into the filter sleeve column 1, reducing the amount of sample residue in the test tube 100. The transport mechanism 6 then transfers the centrifuged filter sleeve column 1 and the test tube 100 to the filtration module 5. The filtration module 5 removes the test tube 100 from the filter sleeve column 1 and then filters the sample in the filter sleeve column 1.

[0084] This application automates the filtration process by using a switch-on / close module 2 to configure a filter sleeve 1 on a test tube 100, and then using a flip module 3 to flip the test tube 100 containing the filter sleeve 1. This reduces the need to extract the sample from the test tube 100 and transfer it into the filter sleeve 1, thus improving filtration efficiency. A centrifugation module 4 centrifuges the sample, ensuring all the sample in the test tube 100 enters the filter sleeve 1, reducing sample residue and preventing waste. Finally, a filtration module 5 filters the sample within the filter sleeve 1, automating the filtration process and reducing the workload of laboratory personnel while also improving filtration efficiency.

[0085] See Figure 1 and Figure 5In some embodiments, the sample processing system further includes a first liquid addition module 7, which is used to add a first target liquid to the test tube 100 containing the sample. The first liquid addition module 7 includes a liquid addition needle 71, a mounting base 72, a liquid addition moving mechanism 73, a first control valve, and a first drive pump. The mounting base 72 is connected to both the liquid addition moving mechanism 73 and the liquid addition needle 71. Specifically, the mounting base 72 is fixedly connected to the liquid addition needle 71, and the mounting base 72 is drivenly connected to the liquid addition moving mechanism 73. The liquid addition moving mechanism 73 drives the mounting base 72 to move, thereby moving the liquid addition needle 71. The liquid addition moving mechanism 73 can move the liquid addition needle 71 between different test tubes 100, so that the needle tip of the liquid addition needle 71 is aligned with the opening of different test tubes 100. It is understandable that multiple liquid dispensing needles 71 can be provided, and these needles 71 can be moved synchronously by the liquid dispensing moving mechanism 73 (e.g., multiple liquid dispensing needles 71 are all installed at intervals on the same mounting base 72). Alternatively, the multiple liquid dispensing needles 71 can be moved separately by the liquid dispensing moving mechanism 73 (e.g., each liquid dispensing needle 71 is installed on a different mounting base 72, and each mounting base 72 is moved independently by the liquid dispensing moving mechanism 73). By providing multiple liquid dispensing needles 71, multiple test tubes 100 can be dispensed simultaneously, thereby increasing the experimental throughput.

[0086] The first control valve is connected to the solvent bottle, the dispensing needle 71, and the first drive pump. The first control valve has multiple interfaces, allowing it to connect to multiple solvent bottles containing different target liquids. The dispensing needle 71 is used to inject the first target liquid from the solvent bottle into the test tube 100 containing the sample. When the dispensing needle 71 needs to add the first target liquid to the test tube 100, the first target liquid in the solvent bottle flows from the solvent bottle to the first control valve under the action of the first drive pump, then flows from the first control valve to the dispensing needle 71, and finally is injected from the dispensing needle 71 into the test tube 100 containing the sample. After the first dispensing module 7 adds the first target liquid to the test tube 100 containing the sample, the transport mechanism 6 can transfer the test tube 100 with the added liquid to the switch cap module 2, which then places the filter sleeve 1 onto the test tube 100. The first target liquid can be prepared according to experimental requirements and is not limited here. The first control valve can be a solenoid valve or an electric valve, etc. Preferably, the first control valve is a multi-channel solenoid valve (such as a three-way solenoid valve, a six-way solenoid valve, etc.). The first driving pump can be an electric reciprocating pump (such as a plunger pump, a diaphragm pump, a piston pump, etc.) or a steam reciprocating pump, preferably, the first driving pump is a plunger pump.

[0087] In some embodiments, the first liquid addition module 7 may be a pipette, which draws the first target liquid from the solvent bottle and then dispenses it into the test tube 100 containing the sample to achieve the target liquid addition function.

[0088] See Figure 1 and Figure 5 The sample processing system also includes a liquid addition and cleaning assembly, which comprises a cleaning tank 74, a second control valve, a second drive pump, and a waste liquid bottle. The second control valve is connected to the cleaning tank 74, the second drive pump, and the waste liquid bottle. In one example, after the dispensing needle 71 injects the solvent from the first solvent bottle into the test tube 100, if the second solvent bottle needs to be injected, to avoid contamination of the second solvent by the first solvent residue in the dispensing needle 71 and the tubing, the dispensing needle 71 and the tubing need to be cleaned first with the solvent from the second solvent bottle. Specifically, the dispensing moving mechanism 73 first moves the dispensing needle 71 to the cleaning tank 74. The solvent from the second solvent bottle flows to the first control valve under the action of the first drive pump, then flows from the first control valve to the dispensing needle 71, and finally is injected from the dispensing needle 71 into the cleaning tank 74, thus achieving the cleaning of the inner wall of the dispensing needle 71 and the tubing. The cleaning tank 74 also has a liquid storage function. When there is enough solvent in the second solvent bottle, the outer wall of the dispensing needle 71 can be cleaned. The cleaning tank 74 can use a second control valve and a second drive pump to discharge the liquid in the cleaning tank 74 into a waste bottle. If it is not necessary to clean the outer wall of the dispensing needle 71, the cleaning tank 74 can be directly connected to the waste bottle, and the liquid discharged from the dispensing needle 71 falls into the cleaning tank 74, which then directly discharges the liquid into the waste bottle. The second control valve and the first control valve can have the same or similar structures, and the second drive pump and the first drive pump can have the same or similar structures.

[0089] See Figure 1 and Figure 6 The sample processing system also includes a mixing module 8, which is used to mix the test tube 100 containing the sample and the first target liquid, so that the sample dissolves in the first target liquid. In some embodiments, the mixing module 8 includes an oscillation mechanism 81 and an oscillation clamping mechanism 82. The oscillation clamping mechanism 82 is connected to the oscillation mechanism 81 and is used to clamp the test tube 100. The oscillation mechanism 81 is used to drive the oscillation clamping mechanism 82 to vibrate, thereby causing the test tube 100 to shake. Specifically, the oscillation mechanism 81 can drive the oscillation clamping mechanism 82 to vibrate vertically and / or horizontally.

[0090] In one example, the mixing module 8 includes a mixing support 83 with a mixing guide rail 831 extending vertically on it. The oscillation mechanism 81 can be driven by a motor or a cylinder; preferably, the oscillation mechanism 81 is a voice coil motor, which is fixed on the mixing support 83. The oscillation clamping mechanism 82 is mounted on the mixing guide rail 831 and driven by the output end of the voice coil motor. The oscillation clamping mechanism 82 can move up and down along the mixing guide rail 831. The oscillation clamping mechanism 82 includes a driving component and a mixing gripper connected to the driving component. The driving component can be driven by a motor or a cylinder. The mixing gripper can include two clamping blocks, each of which can be provided with multiple clamping slots. The driving component drives the two clamping blocks to move closer to each other so that the clamping slots on the two clamping blocks cooperate with each other, enabling the simultaneous clamping of multiple test tubes 100 to improve experimental throughput. Once the mixing gripper clamps the test tube 100, the voice coil motor drives the mixing gripper to move up and down repeatedly, and the test tube 100 moves up and down repeatedly accordingly, thereby achieving the mixing of the sample and the first target liquid in the test tube 100.

[0091] In some embodiments, the mixing module 8 can be a mechanical stirring module or an electromagnetic stirring module. When it is a mechanical stirring module, a stirring rod extends into the test tube 100 to mechanically stir the sample in the test tube 100, thereby homogenizing the sample and the first target liquid. When it is an electromagnetic stirring module, a stir bar is placed in the test tube 100, and a magnet drives the stir bar to rotate, thereby electromagnetically stirring the sample in the test tube 100. The structure of the mechanical stirring module and the electromagnetic stirring module is not limited and can be implemented using relevant existing technologies.

[0092] After the first liquid addition module 7 adds liquid to the test tube 100 containing the sample, the transport mechanism 6 transfers the test tube 100 with the added liquid to the cover switch module 2. The cover switch module 2 places the filter sleeve 1 on the test tube 100. The transport mechanism 6 then transfers the test tube 100 with the filter sleeve 1 to the mixing module 8. After mixing is completed, the mixed test tube 100 and the filter sleeve 1 are transferred to the flipping module 3.

[0093] See Figure 1 and Figure 7In some embodiments, to meet specific experimental requirements and control sample concentration, the sample can be concentrated. For this purpose, the sample processing system may further include a nitrogen blowing module 9, which is used to perform nitrogen blowing treatment on the sample in the test tube 100. The nitrogen blowing module 9 includes a first lifting mechanism 91, a nitrogen blowing needle 92, a connecting seat 93, a first translation mechanism 94, a bracket 95, and a heating component 96. The nitrogen blowing needle 92 is fixedly mounted on the connecting seat 93, which has an air passage connecting the nitrogen blowing needle 92 and a nitrogen source. The nitrogen source can supply nitrogen to the nitrogen blowing needle 92 through the air passage. The nitrogen source can be an external nitrogen cylinder or a nitrogen tank within the nitrogen blowing module 9. The first lifting mechanism 91 is connected to the connecting seat 93 and is used to drive the connecting seat 93 to rise and fall, thereby driving the nitrogen blowing needle 92 to rise and fall. The connecting seat 93 and the first lifting mechanism 91 can be fixedly connected by screws, or they can be quickly connected by pneumatic or magnetic means; no limitation is made here. The first lifting mechanism 91 can be a cylinder, a linear motor, or a lead screw slide module, etc. A flow stabilizer and a manifold can be installed inside the connecting seat 93 to ensure that nitrogen gas can enter each nitrogen blowing needle 92 connected to the connecting seat 93 evenly. A bracket 95 is disposed on the first translation mechanism 94 and is located below the nitrogen blowing needles 92. The bracket 95 is used to hold test tubes 100, and the nitrogen blowing needles 92 can blow nitrogen gas into the test tubes 100 in the bracket 95. The first translation mechanism 94 is used to drive the bracket 95 closer to or further away from the nitrogen blowing needles 92. A heating component 96 is disposed on the first translation mechanism 94. The heating component 96 is used to heat the test tubes 100 on the bracket 95, thereby evaporating the moisture in the sample and concentrating the sample. Combined with the nitrogen blowing needles 92 blowing nitrogen gas into the sample, the concentration effect of the sample can be further improved. The heating component 96 can be a heating film attached to the bottom and / or side of the bracket 95, a heating rod disposed inside the bracket 95, or a water bath heating system, etc., and is not limited here. A vacuum pipe 97 can be installed near the bracket 95. This vacuum pipe 97 is connected to a vacuum device and can promptly remove volatile substances generated in the test tube 100, ensuring the safety of the experiment. To increase the experimental throughput, multiple nitrogen blowing modules 9 can be installed.

[0094] In one example, the transport mechanism 6 can first transfer the test tube 100 to the nitrogen blowing module 9 for nitrogen blowing, and then transfer the nitrogen-blown test tube 100 to the first liquid addition module 7, and add the first target liquid to the nitrogen-concentrated test tube 100 through the first liquid addition module 7. In another example, the transport mechanism 6 can first transfer the test tube 100 to the nitrogen blowing module 9 for nitrogen blowing to concentrate the sample in the test tube 100 to a certain concentration, and then the transport mechanism 6 can directly transfer the test tube 100 to the switch cap module 2 for the configuration of the filter column 1.

[0095] Understandably, in order to save system space and make the structure more compact, the first liquid filling module 7 and the nitrogen blowing module 9 can be arranged adjacent to each other. The first translation mechanism 94 and the bracket 95 are located below the liquid filling needle 71. The first translation mechanism 94 can drive the bracket 95 to move back and forth below the nitrogen blowing needle 92 and the liquid filling needle 71.

[0096] See Figure 1 and Figure 8 The conveying mechanism 6 includes a first moving mechanism 61, a second moving mechanism 62, a third moving mechanism 63, and a conveying clamping assembly 64. The second moving mechanism 62 is disposed on the first moving mechanism 61, and the first moving mechanism 61 drives the second moving mechanism 62 to move along a first direction. The third moving mechanism 63 is disposed on the second moving mechanism 62, and the second moving mechanism 62 drives the third moving mechanism 63 to move along a second direction. The first moving mechanism 61, the second moving mechanism 62, and the third moving mechanism 63 can be a lead screw slide module, a linear motor, or a cylinder, etc. The conveying clamping assembly 64 is disposed on the third moving mechanism 63, and the third moving mechanism 63 drives the conveying clamping assembly 64 to move along a third direction. The first direction, the second direction, and the third direction are mutually perpendicular, and the conveying clamping assembly 64 is used to clamp the test tube 100 and / or the filter sleeve 1. Preferably, the first direction is the x-axis direction, the second direction is the y-axis direction, and the third direction is the z-axis direction. The test tube 100 and / or filter sleeve 1 are moved by the transport mechanism 6, so that the test tube 100 and / or filter sleeve 1 can move in multiple directions, which facilitates the transfer of the test tube 100 and / or filter sleeve 1 between the opening and closing module 2, the flipping module 3, the centrifugation and transfer module 4, the filtration module 5, the first liquid addition module 7, the mixing module 8, and the nitrogen blowing module 9.

[0097] In some embodiments, the transport mechanism 6 further includes a base frame 66, on which the first moving mechanism 61 is mounted. The base frame 66 can be fixed to the workbench 400. In some embodiments, the sample processing system further includes an outer cover, which is disposed on the workbench 400 and surrounds the switch cover module 2, the flipping module 3, the centrifugation transfer module 4, and the filtering module 5. The outer cover can protect the switch cover module 2, the flipping module 3, the centrifugation transfer module 4, and the filtering module 5 to form an independent experimental space. The first moving mechanism 61 can be directly mounted on the outer cover, such as on the top plate of the outer cover. The outer cover is provided with an interactive door to facilitate interaction between the sample processing system and the outside world. An observation window can also be provided on the outer cover to facilitate the experimenter to observe the experimental dynamics.

[0098] It is understandable that the handling mechanism 6 can also be a multi-degree-of-freedom manipulator with a handling clamping component 64, and this is not limited here.

[0099] See Figure 1 , Figure 8 and Figure 9In some embodiments, the transport clamping assembly 64 includes a length direction along the third moving mechanism 63 (e.g., Figure 8 At least two grippers are arranged at intervals along the x-axis (as shown), at least one of which is fixedly connected to the third moving mechanism 63 along the length of the third moving mechanism 63, while the other grippers are movably connected to the third moving mechanism 63 along the length of the third moving mechanism 63. The distance between the grippers can be adaptively adjusted according to the size of the test tube 100. Specifically, the spacing between two adjacent grippers can be adjusted by a lead screw slide module, a linear motor, or a cylinder, etc.

[0100] In one example, the transport and clamping assembly 64 further includes a mounting plate 641 and an adjustment mechanism 65. The mounting plate 641 is driven and connected to a third moving mechanism 63 and is driven to rise and fall by the third moving mechanism 63. The adjustment mechanism 65 is fixed to the mounting plate 641. There are at least two grippers, at least one of which is fixed to the mounting plate 641, and the other grippers are driven and connected to the adjustment mechanism 65. The adjustment mechanism 65 can drive the grippers to move along the length of the third moving mechanism 63. For example, there are two grippers, one of which is fixedly connected to the mounting plate 641, and the other is driven and connected to the adjustment mechanism 65. The distance between the two grippers can be adjusted by the adjustment mechanism 65. The adjustment mechanism 65 can be a lead screw slide module or a cylinder, etc. By setting multiple grippers on the third moving mechanism 63, it is convenient for the transport and clamping assembly 64 to move multiple test tubes 100 and / or filter columns 1 simultaneously, thereby improving the working efficiency of the sample processing system.

[0101] See Figure 1 and Figure 2 In some embodiments, the cap switching module 2 includes a base 21, a cap clamping mechanism 22, and a bottle body clamping mechanism 23 located below the cap clamping mechanism 22. The cap clamping mechanism 22 and the cap clamping mechanism 23 are mounted on the base 21. Optionally, the base 21 may also be provided with a cap recycling component 211 for recycling caps removed from the test tube 100. The bottle body clamping mechanism 23 is used to clamp the test tube 100, and the cap clamping mechanism 22 is used to clamp the cap or the filter sleeve 1. To ensure that the sample in the test tube 100 is not affected by oxidation or volatilization, a cap is installed at the opening of the test tube 100 before installing the filter sleeve 1 on the test tube 100 or before blowing nitrogen onto the filter sleeve 1, so that the cap covers the opening of the test tube 100, thereby protecting the sample in the test tube 100 and ensuring the accuracy of the test data. When it is necessary to blow nitrogen into the sample in the test tube 100 or to configure the filter column 1, the cap on the test tube 100 is separated from the test tube 100 by the cap clamping mechanism 22.

[0102] See Figure 1 and Figure 2The bottle cap clamping mechanism 22 includes a lifting assembly 221, a rotating assembly 222, and a first clamping member 223. The first clamping member 223 is located above the bottle cap recycling member 211. The lifting assembly 221 is connected to the rotating assembly 222. The lifting assembly 221 can be a lead screw slide module, a linear motor, or a cylinder. The rotating assembly 222 is connected to the first clamping member 223. The first clamping member 223 is used to clamp the bottle cap or filter sleeve 1. The rotating assembly 222 is used to drive the first clamping member 223 to rotate. The lifting assembly 221 is used to drive the rotating assembly 222 to move up and down, so that the first clamping member 223 moves closer to or further away from the test tube 100.

[0103] See Figure 1 and Figure 2 The bottle clamping mechanism 23 includes a translation component 231, a support base 232, a second clamping member 233, and a sleeve placement position 234. The translation component 231 can be a lead screw slide module, a linear motor, or a cylinder, etc. The support base 232 is disposed on the translation component 231, and the second clamping member 233 and the sleeve placement position 234 are disposed on the support base 232. The second clamping member 233 is used to clamp the test tube 100, and the sleeve placement position 234 is used to place the filter sleeve 1. The sleeve placement position 234 has a protrusion whose shape matches the opening shape of the filter sleeve 1, and the filter sleeve 1 can be inserted into the protrusion with its opening facing downward. The translation component 231 is used to move the second clamping member 233 or the sleeve placement position 234 to below the first clamping member 223. The first clamping member 223 is used to clamp the filter sleeve 1 and position the filter sleeve 1 in the opening of the test tube 100.

[0104] See Figure 1 and Figure 2 When it is necessary to separate the bottle cap from the test tube 100, the conveying mechanism 6 places the test tube 100 with the bottle cap on the second clamp 233. The second clamp 233 clamps and fixes the test tube 100. The translation component 231 moves the support base 232, so that the second clamp 233 moves below the first clamp 223. The lifting component 221 drives the rotating component 222 and the first clamp 223 to descend, so that the first clamp 223 can clamp and fix the bottle cap. The rotating component 222 then drives the first clamp 223 to rotate. The lifting component 221 rises slowly along with the rotating component 222, so that the bottle cap is separated from the test tube 100. The translation component 231 moves the test tube 100 away from the first clamp 223, so that the bottle cap recovery component 211 can be aligned with the first clamp 223 above. The first clamp 223 releases the bottle cap, and the bottle cap falls into the bottle cap recovery component 211.

[0105] See Figure 1 and Figure 2When a filter sleeve 1 needs to be configured on the test tube 100, the transport mechanism 6 places the test tube 100 on the second clamping member 233. The second clamping member 233 clamps and fixes the test tube 100. The translation component 231 moves the support base 232 so that the sleeve placement position 234 is below the first clamping member 223. The lifting component 221 drives the rotating component 222 and the first clamping member 223 to descend so that the first clamping member 223 can clamp the filter sleeve 1. After the first clamping member 223 clamps the filter sleeve 1, it rises. The translation component 231 moves the support base 232 so that the second clamping member 233 moves to below the first clamping member 223. The lifting component 221 drives the rotating component 222 and the first clamping member 223 to descend so that the filter sleeve 1 is connected with the opening of the test tube 100. When the filter sleeve 1 and the test tube 100 are interference-fitted, the lifting component 221 drives the filter sleeve 1 to descend so that the filter sleeve 1 can be inserted into the test tube 100 for connection; when the filter sleeve 1 and the test tube 100 are screwed together, the lifting component 221 drives the filter sleeve 1 to descend, and the rotating component 222 drives the filter sleeve 1 to rotate so that the filter sleeve 1 and the test tube 100 are screwed together.

[0106] It is understandable that the opening and closing module 2 can also adopt other existing implementation methods, such as using the bottle body clamping mechanism 23 to rotate to tighten or loosen the bottle cap or filter sleeve 1, or using the bottle cap clamping mechanism 22 and the bottle body clamping mechanism 23 to rotate simultaneously to tighten or loosen the bottle cap or filter sleeve 1, which is not limited here.

[0107] See Figure 1 and Figure 4The centrifugal transfer module 4 includes a horizontal rotor 41, multiple baskets 42, and a centrifugal rotation mechanism. The centrifugal rotation mechanism is connected to the horizontal rotor 41 and drives the horizontal rotor 41 to rotate. Multiple baskets 42 are evenly arranged on the horizontal rotor 41 and are used to hold test tubes 100. The centrifugal rotation mechanism drives the horizontal rotor 41 to rotate, thereby causing the baskets 42 to rotate, resulting in centrifugal motion of the test tubes 100 in the baskets 42. The horizontal rotor 41 includes a square base plate 411 and two support rods 412 disposed at each apex of the base plate 411. The centrifugal rotation mechanism is fixedly connected to the base plate 411, and the two support rods 412 at each apex extend outward along two sides of the base plate 411. In some embodiments, the baskets 42 can be disposed between two parallel support rods 412 at two adjacent apex. In some embodiments, the baskets 42 can be disposed between two support rods 412 at any apex. The support rods 412 can extend the distance between the test tubes 100 in the baskets 42 and the centrifugal rotation mechanism, improving the centrifugation effect of the samples in the test tubes 100. The substrate 411 can be square or rectangular, and the two support rods 412 at any vertices are perpendicular to each other. Each basket 42 can hold at least one test tube 100, and the centrifugation transfer module 4 can centrifuge multiple test tubes 100 simultaneously to improve experimental throughput.

[0108] See Figure 1 and Figure 10 Before the test tube 100 is placed on the workbench 400, a label can be manually affixed to the outer surface of the test tube 100 or a label can be applied by a marking machine 300. The label can be a character code, QR code, or barcode, etc., serving as the identification information of the test tube 100. The sample processing system also includes a barcode scanning module 10, which includes a barcode scanner 101, a test tube holder, and a barcode scanning rotation mechanism. The test tube holder is used to hold the test tube 100, and the barcode scanning rotation mechanism is connected to the test tube holder and is used to drive the test tube holder to rotate. The barcode scanner 101 is used to scan the information on the outer surface of the test tube 100, thereby identifying the identification information of the test tube 100. When it is necessary to identify the identification information of the test tube 100, the barcode scanner 101 can be stationary while the test tube holder is rotated by the barcode scanning rotation mechanism, causing the test tube holder to rotate. The barcode scanner 101 can then scan the information on the outer surface of the test tube 100 to identify the identification information of the test tube 100.

[0109] See Figure 1 and Figure 10The test tube holder includes a first test tube holder 102 and a second test tube holder 103. The first test tube holder 102 can hold at least one test tube 100, and the second test tube holder 103 can hold at least one test tube 100. In some embodiments, the barcode scanning rotation mechanism includes a drive motor 104, a first gear 105, and a second gear 106. The first test tube holder 102 is fixedly connected to the first gear 105, and the second test tube holder 103 is fixedly connected to the second gear 106. The first gear 105 and the second gear 106 mesh. The drive motor 104 is driven to rotate the first gear 105 or the second gear 106, thereby rotating the first test tube holder 102 and the second test tube holder 103, so that the test tubes 100 in the first test tube holder 102 and the test tubes 100 in the second test tube holder 103 can rotate. The barcode scanner 101 can scan the markings on the outer surface of the test tubes 100. In some embodiments, the scanning rotation mechanism includes a drive motor 104, a first synchronous pulley, a second synchronous pulley, and a synchronous belt. A first test tube holder 102 is fixedly connected to the first synchronous pulley, and a second test tube holder 103 is fixedly connected to the second synchronous pulley. The synchronous belt is wound around the first and second synchronous pulleys. The drive motor 104 is driven by either the first or second synchronous pulley, and drives the first or second synchronous pulley to rotate, thereby rotating the first and second test tube holders 102 and 103. This allows the test tubes 100 in the first and second test tube holders 102 to rotate, and the barcode scanner 101 to scan the markings on the outer surface of the test tubes 100. Two barcode scanners 101 can be used, with one barcode scanner 101 corresponding to one test tube holder. The barcode scanner 101 can also be used to scan the collection bottle 503, and correspondingly, the test tube holder can be used to hold the collection bottle 503.

[0110] See Figure 1The sample processing system also includes a loading / unloading module 200, which is used to place test tubes 100 and / or filter sleeves 1. Test tubes 100 can be temporarily placed in the loading / unloading module 200 before or after adding samples. Filter sleeves 1 can also be placed in the loading / unloading module 200 before being equipped with the switch cover module 2. The loading / unloading module 200 has multiple material placement positions, each equipped with a positioning mechanism and / or a sensing mechanism. The positioning mechanism is used to position the tray carrying the test tubes 100 and / or filter sleeves 1, ensuring that the test tubes 100 and filter sleeves 1 can be securely stored in the material placement position. The positioning mechanism may include, but is not limited to, at least one of the following: positioning pins, positioning protrusions, positioning grooves, limiting bars, and magnetic components (such as permanent magnets, electromagnets, etc.). The sensing mechanism is used to sense the usage status of the material placement position, such as whether there is an empty space in the material placement position, or whether the material placement position contains a test tube 100 or a filter sleeve 1. Optionally, the loading and unloading module 200 can also be used to place the collection bottle 503, which is used to collect the filtrate obtained by the filtration module 5.

[0111] See Figure 11-14 The filter sleeve 1 includes a first tube 11, a second tube 12, and a connector 13. The first tube 11 and the second tube 12 are connected, and both the first tube 11 and the second tube 12 have an inner cavity, which are interconnected. The first tube 11 has a first opening 111 at the end away from the second tube 12, and the second tube 12 has a second opening 121 at the end away from the first tube 11. The connector 13 is located at the end of the first tube 11 near the first opening 111, and is used to connect the first tube 11 to a test tube 100 containing the sample. The connector 13 has a liquid flow channel for connecting the first tube 11 and the test tube 100. The inner diameter of the first tube 11 is larger than the inner diameter of the second tube 12, which allows the first tube 11 to hold more liquid sample, while the smaller inner diameter of the second tube 12 limits the flow rate of the liquid sample flowing out from the second opening 121. This filter sleeve 1 can be used by setting a filter element in the inner cavity and / or connecting a filter head 504 at the second opening 121.

[0112] See Figure 11-14The liquid flow channels include a first liquid flow channel 131 and a second liquid flow channel 132 that are connected. The first liquid flow channel 131 is located near the test tube 100, and the second liquid flow channel 132 is located near the first tube body 11. The inner diameter of the first liquid flow channel 131 is larger than the inner diameter of the second liquid flow channel 132. The first liquid flow channel 131 and the second liquid flow channel 132 are smoothly connected, so that the connection between the two liquid flow channels forms a guide surface, which facilitates the liquid sample in the test tube 100 to flow more quickly into the first tube body 11. The axes of the first liquid flow channel 131, the second liquid flow channel 132, the first tube body 11, and the second tube body 12 are all collinear. This arrangement facilitates the unobstructed transition of the liquid sample from the test tube 100 to the filter sleeve column 1.

[0113] See Figure 11-14 In some embodiments, the connector 13 is interference-fitted with the test tube 100. When the switch cover module 2 configures the test tube 100 and the filter sleeve 1, the first clamp 223 can clamp and press down the filter sleeve 1 to insert the filter sleeve 1 into the test tube 100.

[0114] In some embodiments, the inner wall of the end of the connector 13 connected to the test tube 100 is provided with an internal thread, and the outer wall of the test tube 100 near the opening is provided with an external thread. The internal thread and the external thread are engaged to allow the filter sleeve 1 to be positioned at the opening of the test tube 100. When the first clamping member 223 clamps the filter sleeve 1 and connects it to the test tube 100, the rotating component 222 needs to drive the filter sleeve 1 to rotate so that the filter sleeve 1 is screwed and fixed to the test tube 100.

[0115] The connector 13 and the first tube 11 can be either an interference fit or a threaded fit, which is not limited here. Preferably, one end of the connector 13 is threaded to the test tube 100, and the other end is interference fit to the first tube 11.

[0116] See Figure 11-14 The filter sleeve 1 also includes a plug 14, which is detachably connected to the end of the second tube 12 away from the first tube 11. The plug 14 is used to seal the second opening 121 before filtration to prevent the liquid sample in the inner cavity from flowing out of the second opening 121 prematurely. Specifically, the plug 14 can be screwed to the second tube 12 by threads, or the plug 14 can be fixed to the second tube 12 by interference fit, or the plug 14 can be magnetically attracted to the second tube 12, which is not limited here. After the flipping module 3 flips the test tube 100 equipped with the filter sleeve 1, the filter sleeve 1 is located below the test tube 100 with the second opening 121 facing downwards. When it is necessary to discharge the sample in the filter sleeve 1, the plug 14 can be removed from the second opening 121, and the sample can then be discharged from the second opening 121.

[0117] In some embodiments, the filter sleeve 1 further includes a filter element located inside the first tube 11 and near one end of the second tube 12. The filter element is used to filter the sample inside the first tube 11. This configuration allows for the filtration of liquid samples using the built-in filter element, eliminating the need for an external filter head 504 which occupies additional space and simplifying the process by eliminating the need for an external filter head 504. The specific structure and composition of the filter element are not limited; for example, the filter element can be composed of diatomaceous earth or silica gel.

[0118] See Figure 15 and Figure 16 The filter module 5 includes a support frame 51 and a filter module 52, with the filter module 52 mounted on the support frame 51. The filter module 52 includes a filter gripper assembly and a pressure regulating mechanism. The filter gripper assembly includes a first drive mechanism 521 and filter grippers 522 driven and connected to the first drive mechanism 521. The first drive mechanism 521 is mounted on the support frame 51 and drives the filter grippers 522 to clamp the filter sleeve column 1. The pressure regulating mechanism connects to the filter sleeve column 1 and regulates the air pressure inside the filter sleeve column 1 to filter the sample inside the filter sleeve column 1.

[0119] Specifically, after the connector 13 of the filter sleeve 1, along with the test tube 100, is removed from the first tube body 11, the filter clamp 522 clamps the filter sleeve 1. The pressure regulating mechanism can then connect and communicate with the first opening 111, facilitating the adjustment of the air pressure inside the filter sleeve 1 to filter the sample within it. When it is necessary to filter the liquid sample in the filter sleeve 1, a filter element can be installed inside the filter sleeve 1 and / or a filter head 504 can be installed externally. The pressure regulating mechanism adjusts the air pressure inside the filter sleeve 1, causing the liquid sample inside the filter sleeve 1 to pass through the filter element inside the filter sleeve 1 and / or the filter head 504 under the action of air pressure, thereby achieving the filtration of the sample inside the filter sleeve 1.

[0120] In this embodiment, the specific structure of the first driving mechanism 521 is not limited. For example, the first driving mechanism 521 can be a driving mechanism such as a motor or cylinder. The filter gripper 522 can be two or more clamping blocks, each clamping block having a clamping surface for clamping the filter sleeve 1. The clamping surface can be a plane, a curved surface, or a combination of planes and planes, planes and curved surfaces, curved surfaces and curved surfaces, etc., and is not limited here. Elastic elements (such as rubber pads, silicone pads, etc.) and / or anti-slip elements (such as granular, toothed, etc.) can also be provided on the clamping surface. By providing elastic elements, rigid collisions between the filter gripper 522 and the filter sleeve 1 can be avoided, thus protecting the filter sleeve 1. By providing anti-slip elements, the friction between the filter gripper 522 and the filter sleeve 1 can be increased, preventing the filter sleeve 1 from falling off. The first driving mechanism 521 is connected to each clamping block of the filter gripper 522 to drive each clamping block to move closer or further away from each other. The support frame 51 supports the filter module 52. The support frame 51 can be a flat plate or a gantry frame, etc., which are not limited here.

[0121] The filtration module 5 uses filter grippers 522 to hold the filter sleeve 1. When it is necessary to filter the liquid sample in the filter sleeve 1, the air pressure in the filter sleeve 1 is adjusted by a pressure regulating mechanism, allowing the liquid sample in its inner cavity to be filtered through the internal filter elements and / or the external filter head 504. This automates the filtration operation, reducing the workload of laboratory personnel and improving filtration efficiency. Furthermore, it avoids direct contact between laboratory personnel and liquid samples, ensuring their health and safety.

[0122] The filter module 52 also includes an adapter 523, which is mounted on the support frame 51 and located above the filter clamp 522. One end of the adapter 523 is connected to the pressure regulating mechanism, and the other end is used for a sealed connection with the filter sleeve 1. The adapter 523 has a first channel for connecting the filter sleeve 1 and the pressure regulating mechanism. The first channel extends through both opposite ends of the adapter 523, with one end connected to the pressure regulating mechanism and the other end connected to the filter sleeve 1. The adapter 523 and the filter sleeve 1 can be sealed using methods such as elastic abutment or interference fit. When the filter clamp 522 holds the filter sleeve 1, to ensure that the pressure regulating mechanism can adjust the air pressure inside the filter sleeve 1, the adapter 523 can mate with the first opening 111 of the filter sleeve 1, thus sealing the adapter 523 and the filter sleeve 1. When the pressure regulating mechanism adjusts the air pressure inside the filter sleeve 1, gas will not leak from the first opening 111.

[0123] In some embodiments, the pressure regulating mechanism includes a positive pressure component. One end of the positive pressure component is connected to the first channel, and the other end is connected to a gas source. The positive pressure component is used to pressurize the filter sleeve 1. By pressurizing the filter sleeve 1 with the positive pressure component, the gas pressure inside the filter sleeve 1 is increased, allowing the liquid sample inside the filter sleeve 1 to flow out under pressure. The gas source connected to the positive pressure component can be an inert gas such as nitrogen or helium that does not react with the liquid sample.

[0124] In some embodiments, the pressure regulating mechanism further includes a pressure relief component. One end of the pressure relief component is connected to the first channel, and the other end is connected to the atmospheric environment. The pressure relief component is used to depressurize the filter sleeve 1 when the adapter 523 is connected to the filter sleeve 1. Specifically, during the docking process between the adapter 523 and the filter sleeve 1, the adapter 523 gradually extends into the filter sleeve 1, compressing the gas in the inner cavity of the filter sleeve 1 and increasing the gas pressure in the inner cavity. To prevent the liquid sample from flowing out prematurely before the filtration preparation is completed due to the increased gas pressure in the inner cavity, the pressure relief component is opened simultaneously with the docking of the adapter 523 and the filter sleeve 1. By depressurizing the inner cavity through the pressure relief component, the gas pressure in the inner cavity of the adapter 523 and the filter sleeve 1 is always at the level of the external ambient gas pressure during docking.

[0125] In some embodiments, the pressure regulating mechanism further includes a negative pressure component, which is connected to the first channel and is used to create a negative pressure inside the filter sleeve 1. When the adapter 523 is connected to the filter sleeve 1, the pressure relief component keeps the air pressure in the inner cavity at the same level as the external ambient air pressure. After the adapter 523 is fully and tightly connected to the filter sleeve 1, the pressure relief component closes and the negative pressure component opens, creating a negative pressure in the inner cavity.

[0126] In one example, without the plug 14 on the filter sleeve column 1, when the negative pressure component creates negative pressure in the inner cavity, ambient gas can enter the inner cavity through the second opening 121. The gas pushes the liquid in the inner cavity upwards, causing the liquid to rise. At this time, the negative pressure created by the negative pressure component prevents the liquid sample in the inner cavity from prematurely flowing out of the filter sleeve column 1 due to gravity. Once the liquid rises to a suitable height or the filtration preparation is complete, the negative pressure component is turned off, and the positive pressure component is activated to pressurize the inner cavity. The liquid in the inner cavity flows out of the filter sleeve column 1 under the action of air pressure, thus achieving the filtration operation of the liquid in the filter sleeve column 1.

[0127] In another example, when a plug 14 is installed at the end of the filter column 1, a negative pressure assembly is used to create negative pressure in the inner cavity before unloading the plug 14. This prevents liquid from splashing or dripping out of the inner cavity during plug 14 unloading, thus avoiding waste of liquid sample and contamination of the experimental environment. After the plug 14 is unloaded, the negative pressure assembly is turned off, and the positive pressure assembly is activated to pressurize the inner cavity. The liquid in the inner cavity flows out of the filter column 1 under the action of air pressure, thereby achieving the filtration operation of the liquid inside the filter column 1.

[0128] The negative pressure assembly may include a vacuum generator, a diaphragm pump, or a plunger pump. Further, the negative pressure assembly may also include a pressure regulating valve and a throttle valve, used in conjunction with the vacuum generator, diaphragm pump, or plunger pump. The pressure regulating valve can adjust the pressure value within the filter sleeve 1, and the throttle valve can adjust the gas flow rate. In one example, the negative pressure assembly includes a vacuum generator, a pressure regulating valve, and a throttle valve connected in sequence, wherein the throttle valve is connected to the first channel of adapter 523. It is understood that the connection order of the pressure regulating valve and the throttle valve can be interchanged.

[0129] See Figure 18 In some embodiments, the pressure relief assembly includes a first switching valve 525, one end of which is connected to a first channel, and the other end of which is connected to the atmospheric environment 800. During the docking of the adapter 523 with the filter sleeve 1, the first switching valve 525 opens, and the gas inside the filter sleeve 1, due to compression, flows through the first channel to the first switching valve 525, and then is discharged from the first switching valve 525 into the atmospheric environment 800, so as to maintain the balance between the gas pressure inside the filter sleeve 1 and the atmospheric pressure. After the adapter 523 and the filter sleeve 1 are docked, the first switching valve 525 is closed. The first switching valve 525 can be a solenoid valve, ball valve, butterfly valve, gate valve, shut-off valve, etc., and is not limited thereto. The pressure regulating mechanism also includes a digital display 529, which is connected to the first channel and is used to display the gas pressure inside the filter sleeve 1, allowing the experimenter to understand the gas pressure inside the filter sleeve 1 in a timely and intuitive manner.

[0130] See Figure 18In some embodiments, the positive pressure assembly includes a second switching valve 526 and a proportional valve 527. One end of the second switching valve 526 is connected to the first channel, and the other end of the second switching valve 526 is connected to one end of the proportional valve 527. The other end of the proportional valve 527 is connected to a nitrogen output source 528. When the positive pressure assembly needs to pressurize the inner cavity, the second switching valve 526 opens, the proportional valve 527 opens, and the nitrogen output source 528 introduces a certain amount of nitrogen into the inner cavity through the proportional valve 527 and the second switching valve 526, thereby increasing the gas pressure in the inner cavity and squeezing the liquid out of the filter sleeve column 1. The proportional valve 527 can be a flow proportional valve, which can adjust the nitrogen flow rate according to the volume of the filter sleeve column 1, ensuring that the liquid in the inner cavity can be flushed out while saving nitrogen and reducing costs. The proportional valve 527 can also be a pressure proportional valve, which can control the gas pressure input to the filter sleeve column 1, thereby adjusting the flow rate during liquid filtration. The second switching valve 526 is the same as or similar to the first switching valve 525, and can also be a solenoid valve, ball valve, butterfly valve, gate valve, globe valve, etc., without limitation.

[0131] The filter module 52 also includes a second liquid dispensing module. One end of the second liquid dispensing module is connected to a solvent bottle, and the other end is connected to an adapter 523. The second liquid dispensing module is used to deliver a second target liquid into the filter sleeve 1. The adapter 523 also has a second channel for connecting the filter sleeve 1 and the second liquid dispensing mechanism. The second channel and the first channel are independent of each other.

[0132] In one example, when other liquids are being supplied to the filter sleeve column 1 using the second liquid supply module, the filter clamp 522 holds the filter sleeve column 1, and after the adapter 523 successfully connects to the filter sleeve column 1, the second liquid supply module is activated to inject the liquid into the filter sleeve column 1. Then, the negative pressure assembly is activated to create negative pressure inside the filter sleeve column 1, unloading the plug 14, and then the positive pressure assembly is activated to filter the liquid sample inside the filter sleeve column 1.

[0133] In another example, if it is necessary to filter the liquid sample in the filter column 1 multiple times to avoid liquid sample residue, after completing one filtration, the second liquid addition module can be used to inject the specified liquid into the filter column 1 and filter again, and so on, until the filtration is completed.

[0134] The specific structure of the second liquid-filling module is not limited and can adopt commonly available liquid-filling mechanisms. The structure of the second liquid-filling module can be the same as or similar to that of the first liquid-filling module 7. In one example, the second liquid-filling module and the first liquid-filling module 7 can be the same module. In another example, the negative pressure component and the second liquid-filling module can be the same module, using a plunger pump to directly draw in negative pressure or liquid. In yet another example, the negative pressure component, the second liquid-filling module, and the first liquid-filling module 7 can be the same module. All three scenarios simplify the system structure and reduce equipment costs.

[0135] The filtration module 5 also includes a second lifting mechanism 53, which is mounted on the support frame 51. The filtration module 52 is driven to move up and down via the second lifting mechanism 53, ensuring that the filter gripper 522 can move closer to or further away from the collection bottle 503. This allows the filtered liquid to flow accurately into the collection bottle 503 when the filter gripper 522 moves the filter sleeve 1 closer to the collection bottle 503. The specific structure of the second lifting mechanism 53 is not limited; for example, it can be a combination of a lead screw motor and a guide component (such as a guide rail or guide rod).

[0136] The filter module 52 also includes a third lifting mechanism 524, which is mounted on the support frame 51. The adapter 523 is driven to the third lifting mechanism 524, which is used to drive the adapter 523 closer to or further away from the filter gripper 522. Specifically, the third lifting mechanism 524 can drive the adapter 523 to move up and down above the filter gripper 522, so that after the adapter 523 approaches the filter gripper 522, it can combine with the filter sleeve post 1 on the filter gripper 522. The specific structure of the third lifting mechanism 524 is not limited; for example, the third lifting mechanism 524 can be a combination of a screw motor and a guide (such as a guide rail, guide rod, etc.).

[0137] See Figure 15-17 The filter module 5 also includes a base 54 and a placement rack 55 located on the base 54. The placement rack 55 is provided with at least one first placement position 551 for placing a collection bottle 503 for receiving the filtered liquid.

[0138] The filter module 5 also includes a second translation mechanism 56 and / or a third translation mechanism 57. A base 54 is disposed on the second translation mechanism 56, which drives the base 54 to move in a fourth direction, causing the collection bottle 503 on the placement rack 55 to move closer to or further away from the filter gripper 522. The second translation mechanism 56 can be disposed on the support frame 51 or the worktable 400. When the base 54 moves in the fourth direction, the placement rack 55 also moves in the fourth direction, and the collection bottle 503 also moves in the fourth direction, allowing the second translation mechanism 56 to control the collection bottle 503 on the placement rack 55 to move closer to or further away from the filter gripper 522.

[0139] See Figure 15 and Figure 16 The third translation mechanism 57 is disposed on the support frame 51 and connected to the filter module 52. The third translation mechanism 57 is used to drive the filter module 52 to move along the fifth direction, so that the filter gripper 522 moves closer to or further away from the collection bottle 503. The fourth direction is parallel or perpendicular to the fifth direction. When the filter module 5 includes the second translation mechanism 56 and the third translation mechanism 57, the fourth direction is parallel or perpendicular to the fifth direction. When the fourth direction is perpendicular to the fifth direction, the fourth direction can be... Figure 1 The y-axis direction shown can be the fifth direction. Figure 1 As shown in the x-axis direction, the third lifting mechanism 524 drives the adapter 523 along... Figure 1 As shown, the second lifting mechanism 53 drives the filter module 52 to move along the z-axis direction. When the fourth and fifth directions are parallel, both the fourth and fifth directions can be the x-axis direction, or both can be the y-axis direction. The structures of the second translation mechanism 56 and the third translation mechanism 57 can be the same or similar, and their specific structures are not limited. For example, both the second translation mechanism 56 and the third translation mechanism 57 are combinations of lead screw motors and guide components (such as guide rails, guide rods, etc.).

[0140] The filter module 5 also includes a fixing clamping assembly 58, which is disposed on the base 54. When the base 54 moves in the fourth direction, the fixing clamping assembly 58 also moves in the fourth direction. The fixing clamping assembly 58 includes a second drive mechanism 581 and a fixing jaw 582 drivenly connected to the second drive mechanism 581. The second drive mechanism 581 can drive the fixing jaw 582 to close or open, so that the fixing jaw 582 can clamp and fix the filter sleeve 1, or release the filter sleeve 1 being clamped. The specific structure of the second drive mechanism 581 is not limited. For example, the second drive mechanism 581 can be a motor, cylinder, or other drive mechanism. The filter sleeve 1 can be moved to the fixing jaw 582 by the conveying mechanism 6, and the fixing jaw 582 clamps the filter sleeve 1. The fixing clamping assembly 58, in conjunction with the second translation mechanism 56, can deliver the filter sleeve 1 to the filter jaw 522. The structure of the fixing jaw 582 can be the same as or similar to the filter jaw 522, and is not limited here. In one example, when the filter clamp 522 is inconvenient to directly clamp the filter sleeve 1, the filter sleeve 1 can be fixed to the fixed clamp 582 by setting the fixed clamping assembly 58, and then the filter clamp 522 clamps the filter sleeve 1. In another example, the fixed clamp 582 cooperates with the filter clamp 522 or the conveying mechanism 6 to detach the test tube 100 and the connector 13 from the first tube body 11, and then the filter clamp 522 clamps the filter sleeve 1.

[0141] It is understood that the test tube 100 and the connector 13 can be separated from the first tube body 11 by using the fixed clamp 582 in conjunction with the filter clamp 522 or the conveying mechanism 6, or the test tube 100 and the connector 13 can be separated from the first tube body 11 by using the switch cover module 2. No limitation is made here.

[0142] The filter module 5 also includes an unloading component 501, located below the filter gripper 522. The unloading component 501 is used to separate the plug 14 from the second tube 12. If the plug 14 and the second tube 12 are threadedly connected, the unloading component 501 engages or clamps the plug 14, and the filter gripper 522 clamps the first tube 11. The filter gripper 522 drives the first tube 11 to rotate, or the unloading component 501 drives the plug 14 to rotate, thus separating the plug 14 from the second tube 12. If the plug 14 and the second tube 12 are fixed by interference fit or magnetic attraction, the unloading component 501 engages or clamps the plug 14, and the filter gripper 522 clamps the first tube 11. The filter gripper 522 drives the first tube 11 to rise, or the unloading component 501 drives the plug 14 to fall, thus detaching the plug 14 from the second tube 12.

[0143] It is understandable that the filter sleeve 1 can be equipped with both the filter element and the plug 14, or only the filter element or the plug 14. When only the plug 14 is installed, the filter sleeve 1 can be used in conjunction with the filter head 504. In addition, when the filter sleeve 1 is equipped with the filter element, it can also be used in conjunction with the filter head 504 to improve the filtration effect.

[0144] The placement rack 55 is also provided with at least one second placement position 552, which is used to place the filter head 504; after the unloading component 501 removes the plug 14, the filter gripper 522 drives the filter sleeve column 1 to grab the filter head 504. Without a filter element installed inside the first tube 11, after unloading the plug 14, the placement rack 55 is moved below the filter gripper 522, aligning the second opening 121 with one of the filter heads 504. The second lifting mechanism 53 lowers the filter gripper 522, causing the filter sleeve 1 on the filter gripper 522 to descend as well, until the bottom end of the second tube 12 is secured to the filter head 504, thus fixing the second tube 12 and the filter head 504 together. Then, the second lifting mechanism 53 raises the filter sleeve 1 and the filter head 504, moving the collection bottle 503 below the filter head 504 or moving the filter head 504 above the collection bottle 503. The positive pressure component pressurizes the inner cavity, causing the liquid sample in the inner cavity to fall into the collection bottle 503 after being filtered by the filter head 504. The arrangement of the first placement position 551 and the second placement position 552 is not limited; both can be arranged in an array. The first placement position 551 and the second placement position 552 can be arranged in a cross manner, so that the weight of the placement rack 55 can be evenly distributed; the first placement position 551 and the second placement position 552 can also be arranged in separate areas, such as the first placement position 551 on the left side of the placement rack 55 and the second placement position 552 on the right side of the placement rack 55, which facilitates the loading and unloading of materials.

[0145] The filtration module 5 also includes a recovery component 59, which is mounted on the base 54 and moves with the base 54. An unloading component 501 is located above the recovery component 59, facilitating the direct fall of the unloaded plug 14 into the recovery component 59. A second translation mechanism 56 can move the recovery component 59 below the filter gripper 522. The recovery component 59 may include, but is not limited to, a consumables recovery box 591, a waste liquid pool 592, and a buffer box 593. The consumables recovery box 591 is used to recover experimental consumables such as test tubes 100, connectors 13, filter sleeves 1, filter heads 504, and plugs 14. The waste liquid pool 592 is used for discharging waste liquid from the second liquid addition module; for example, waste liquid from cleaning the pipeline during solvent replacement is discharged to the waste liquid pool 592 via the adapter 523. The buffer box 593 is used to temporarily store the malfunctioning filter column 1. If the filter column 1 is blocked and cannot filter normally, by temporarily storing the malfunctioning filter column 1, the experimenter can deal with the malfunction in time or remove the liquid sample inside, thus avoiding waste of liquid sample.

[0146] The filtration module 5 also includes a detector 502, which is mounted on the base 54. The detector 502 is used to detect whether the filter sleeve 1 has pierced the filter head 504. When it is necessary to filter the liquid sample in the filter sleeve 1, the unloading component 501 separates the plug 14 from the second tube 12, and the filter gripper 522 drives the filter sleeve 1 to pierce the filter head 504. Then, the detector 502 is used to detect whether the filter head 504 has been successfully pierced on the filter sleeve 1. If the filter sleeve 1 has correctly pierced the filter head 504, the pressure regulating mechanism pressurizes the inner cavity, so that the liquid sample in the inner cavity falls into the collection bottle 503 after being filtered by the filter head 504. If the filter sleeve 1 has not pierced the filter head 504 or the filter head 504 is pierced crookedly, the filter head 504 is re-pierced or an alarm is triggered to notify the experimental personnel for handling. The detector 502 may include, but is not limited to, sensors (such as laser sensors, infrared sensors, etc.), cameras, etc.

[0147] In some embodiments, such as Figure 15 and 16 As shown, there can be multiple filter modules 52, and the multiple filter modules 52 are arranged in the horizontal direction (e.g., Figure 1 The filters (as shown in the x-axis direction) are arranged at intervals on the support frame 51. Each filter module 52 can filter the sample in one filter sleeve 1, and multiple filter modules 52 can simultaneously filter multiple filter sleeves 1, greatly increasing experimental throughput and further improving filtration efficiency. In addition, multiple fixing clamping components 58 can be set, and multiple fixing claws 582 can cooperate with multiple filter claws 522 to realize the synchronous transfer of multiple filter sleeves 1.

[0148] See Figure 1 and Figure 19 To shorten the interaction time between functional modules and improve experimental efficiency, the following modules are arranged sequentially around the conveying module 6: cover opening / closing module 2, nitrogen blowing module 9, first liquid addition module 7, mixing module 8, flipping module 3, centrifugal transfer module 4, loading / unloading module 200, barcode scanning module 10, and filtration module 5. The loading / unloading module 200 is located near the interaction door on the outer cover for easy material interaction with the outside.

[0149] See Figure 1 The sample processing system also includes a marking machine 300, which can mark the collection bottle 503 and / or test tube 100. Specifically, the marking machine 300 can use laser marking to imprint markings on the side of the collection bottle 503 or test tube 100. The specific structure of the marking machine 300 is not limited and can be found in existing related technologies.

[0150] See Figure 1In some embodiments, the sample processing system further includes a transfer module 500, a robotic arm 600, and a material rack 700. The material rack 700 can store collection bottles 503 and / or test tubes 100. The robotic arm 600 is used to grab the collection bottles 503 or test tubes 100. The robotic arm 600 can grab the collection bottles 503 or test tubes 100 on the material rack 700 and place them on the marking machine 300. The marking machine 300 then marks the collection bottles 503 or test tubes 100. The robotic arm 600 then grabs the marked collection bottles 503 or test tubes 100 and places them on the transfer module 500. The transfer module 500 transports the marked collection bottles 503 or test tubes 100 to the conveying mechanism 6. The conveying mechanism 6 then transports the marked collection bottles 503 or test tubes 100 to the loading and unloading module 200 for storage.

[0151] In some embodiments, the sample processing system further includes a mobile robot for picking up and placing materials on the loading and unloading module 200, such as placing test tubes 100, filter column 1, collection bottle 503, filter head 504, etc., or removing collection bottle 503 containing filtrate. By setting up a mobile robot, a fully automated experimental process can be achieved, reducing human intervention.

[0152] The solution of this application has been described in detail above with reference to the accompanying drawings. In the above embodiments, the descriptions of each embodiment have different focuses; for parts not described in detail in a certain embodiment, please refer to the relevant descriptions of other embodiments. Those skilled in the art should also understand that the actions and modules involved in the specification are not necessarily essential to this application. Furthermore, it is understood that the steps in the method of this application embodiment can be adjusted, combined, and deleted according to actual needs, and the modules in the device of this application embodiment can be combined, divided, and deleted according to actual needs.

[0153] The various embodiments of this application have been described above. These descriptions are exemplary and not exhaustive, nor are they limited to the disclosed embodiments. Many modifications and variations will be apparent to those skilled in the art without departing from the scope and spirit of the described embodiments. The terminology used herein is chosen to best explain the principles, practical application, or improvement of the technology in the market, or to enable others skilled in the art to understand the embodiments disclosed herein.

Claims

1. A sample processing system, characterized in that, include: Filter sleeve column; A switch cap module, wherein the switch cap module is used to configure the filter sleeve column for the opening of the test tube containing the sample; A flipping module, which is used to flip the test tube containing the filter sleeve column; Centrifugal transfer module, which is used to centrifuge the sample in the inverted filter column; Filtering module, the filtering module being used to filter the sample inside the filter sleeve column; A transport mechanism is used to transport test tubes and / or filter sleeves between the switch cover module, the flip module, the centrifugal transfer module and the filter module.

2. The sample processing system according to claim 1, characterized in that: The sample processing system further includes a first liquid addition module, which is used to add a first target liquid to a test tube containing a sample; The first liquid addition module includes a liquid addition needle, a mounting base, a liquid addition moving mechanism, a first control valve, and a first drive pump; the mounting base is connected to the liquid addition moving mechanism and the liquid addition needle respectively, and the liquid addition moving mechanism is used to drive the mounting base to move, thereby driving the liquid addition needle to move; the first control valve is connected to the solvent bottle, the liquid addition needle, and the first drive pump respectively, and the liquid addition needle is used to inject the first target liquid in the solvent bottle into the test tube containing the sample; the transport mechanism is used to transfer the test tube after liquid addition is completed to the switch cap module.

3. The sample processing system according to claim 2, characterized in that: The sample processing system also includes a mixing module, which is used to mix the test tube containing the sample and the first target liquid. The mixing module includes an oscillation mechanism and an oscillation clamping mechanism. The oscillation clamping mechanism is connected to the oscillation mechanism and is used to clamp the test tube. The oscillation mechanism is used to drive the oscillation clamping mechanism to vibrate, thereby causing the test tube to shake. The transport mechanism is used to transfer the test tube equipped with the filter sleeve column to the mixing module, and after mixing is completed, it is transferred to the flipping module.

4. The sample processing system according to claim 2, characterized in that: The sample processing system also includes a nitrogen blowing module, which is used to perform nitrogen blowing treatment on the sample in the test tube; The nitrogen blowing module includes a first lifting mechanism, a nitrogen blowing needle, a connecting seat, a first translation mechanism, a bracket, and a heating component. The nitrogen blowing needle is fixedly mounted on the connecting seat, which has an air passage that connects the nitrogen blowing needle and a nitrogen source. The first lifting mechanism is connected to the connecting seat and drives the connecting seat to rise and fall, thereby raising and lowering the nitrogen blowing needle. The bracket is mounted on the first translation mechanism and located below the nitrogen blowing needle. The bracket is used to hold test tubes, and the first translation mechanism drives the bracket to move closer to or away from the nitrogen blowing needle. The heating component is mounted on the first translation mechanism and heats the test tubes on the bracket.

5. The sample processing system according to claim 1, characterized in that: The transport mechanism includes a first moving mechanism, a second moving mechanism, a third moving mechanism, and a transport clamping assembly; the second moving mechanism is disposed on the first moving mechanism, and the first moving mechanism is used to drive the second moving mechanism to move along a first direction; the third moving mechanism is disposed on the second moving mechanism, and the second moving mechanism is used to drive the third moving mechanism to move along a second direction; the transport clamping assembly is disposed on the third moving mechanism, and the third moving mechanism is used to drive the transport clamping assembly to move along a third direction; wherein, the first direction, the second direction, and the third direction are perpendicular to each other, and the transport clamping assembly is used to clamp test tubes and / or filter sleeves.

6. The sample processing system according to claim 5, characterized in that: The transport clamping assembly includes at least two grippers spaced apart along the length direction of the third moving mechanism, wherein at least one of the grippers is fixedly connected to the third moving mechanism along the length direction of the third moving mechanism, and the remaining grippers are movably connected to the third moving mechanism along the length direction of the third moving mechanism.

7. The sample processing system according to claim 1, characterized in that: The switch cap module includes a cap clamping mechanism and a bottle body clamping mechanism located below the cap clamping mechanism. The bottle body clamping mechanism is used to clamp test tubes, and the cap clamping mechanism is used to clamp caps or filter sleeves. The bottle cap clamping mechanism includes a lifting component, a rotating component, and a first clamping member. The lifting component is connected to the rotating component, and the rotating component is connected to the first clamping member. The first clamping member is used to clamp a bottle cap or filter sleeve column. The rotating component is used to drive the first clamping member to rotate. The lifting component is used to drive the rotating component to move up and down so that the first clamping member is closer to or further away from the test tube. The bottle clamping mechanism includes a translation component, a support base, a second clamping member, and a sleeve placement position. The support base is disposed on the translation component, and the second clamping member and the sleeve placement position are disposed on the support base. The second clamping member is used to clamp the test tube, and the sleeve placement position is used to place the filter sleeve. The translation component is used to move the second clamping member or the sleeve placement position to below the first clamping member. The first clamping member is used to clamp the filter sleeve and position the filter sleeve at the opening of the test tube.

8. The sample processing system according to claim 1, characterized in that: The centrifugal transfer module includes a horizontal rotor, multiple baskets, and a centrifugal rotation mechanism; the centrifugal rotation mechanism is connected to the horizontal rotor and is used to drive the horizontal rotor to rotate; the multiple baskets are evenly arranged on the horizontal rotor and are used to place test tubes. The horizontal rotor includes a square base plate and two support rods disposed at each apex of the base plate. The two support rods at each apex extend outward along two sides of the base plate. The basket is disposed between two parallel support rods at two adjacent apex, or the basket is disposed between two support rods at any apex.

9. The sample processing system according to claim 1, characterized in that: The sample processing system also includes a barcode scanning module, which includes a barcode scanner, a test tube holder, and a barcode scanning rotation mechanism. The test tube holder is used to hold test tubes, the barcode scanning rotation mechanism is connected to the test tube holder, the barcode scanning rotation mechanism is used to drive the test tube holder to rotate, and the barcode scanner is used to scan the test tubes.

10. The sample processing system according to claim 9, characterized in that: The test tube holder includes a first test tube holder and a second test tube holder; the barcode scanning and rotating mechanism includes a drive motor, a first gear, and a second gear. The first test tube holder is fixedly connected to the first gear, and the second test tube holder is fixedly connected to the second gear. The first gear and the second gear mesh with each other. The drive motor is driven by either the first gear or the second gear, and is used to drive the first gear or the second gear to rotate, thereby rotating the first test tube holder and the second test tube holder; or The scanning and rotating mechanism includes a drive motor, a first synchronous pulley, a second synchronous pulley, and a synchronous belt. The first test tube holder is fixedly connected to the first synchronous pulley, and the second test tube holder is fixedly connected to the second synchronous pulley. The synchronous belt is wound around the first synchronous pulley and the second synchronous pulley. The drive motor is drivenly connected to the first synchronous pulley or the second synchronous pulley. The drive motor is used to drive the first synchronous pulley or the second synchronous pulley to rotate, thereby driving the first test tube holder and the second test tube holder to rotate.

11. The sample processing system according to claim 1, characterized in that: The sample processing system also includes a loading and unloading module, which is used to place test tubes and / or filter columns. The loading and unloading module is provided with multiple material placement positions, each of which is provided with a positioning mechanism and / or a sensing mechanism. The positioning mechanism is used to position the tray carrying the test tubes and / or filter columns, and the sensing mechanism is used to sense the usage status of the material placement position. The positioning mechanism includes at least one of a positioning pin, a limiting strip, and a magnetic suction component.

12. The sample processing system according to any one of claims 1-11, characterized in that: The filter sleeve includes a first tube, a second tube, and a connector. The first tube is connected to the second tube. The first tube has a first opening at the end away from the second tube, and the second tube has a second opening at the end away from the first tube. The connector is located at the end of the first tube near the first opening. The connector is used to connect the first tube to a test tube containing a sample. The connector has a liquid flow channel for connecting the first tube and the test tube. The inner diameter of the first tube is larger than the inner diameter of the second tube.

13. The sample processing system according to claim 12, characterized in that: The liquid flow channel includes a first liquid flow channel and a second liquid flow channel that are connected to each other. The first liquid flow channel is closer to the test tube, and the second liquid flow channel is closer to the first tube body. The inner diameter of the first liquid flow channel is larger than the inner diameter of the second liquid flow channel. The axes of the first liquid flow channel, the second liquid flow channel, the first tube body, and the second tube body are all collinear.

14. The sample processing system according to claim 12, characterized in that: The connector is interference-fitted to the test tube; or The inner wall of the end of the connector that is connected to the test tube is provided with an internal thread, and the outer wall of the test tube near the opening is provided with an external thread. The internal thread and the external thread are engaged to allow the filter sleeve to be positioned at the opening of the test tube.

15. The sample processing system according to claim 12, characterized in that: The filter sleeve also includes a plug, which is detachably connected to the end of the second tube away from the first tube. The plug is used to seal the second opening before filtration.

16. The sample processing system according to claim 12, characterized in that: The filter sleeve also includes a filter element, which is located inside the first tube and near one end of the second tube. The filter element is used to filter the sample inside the first tube.

17. The sample processing system according to claim 12, characterized in that: The filtration module includes a support frame and a filter module, the filter module being disposed on the support frame; wherein, the filter module includes a filter gripper assembly and a pressure regulating mechanism; The filter gripper assembly includes a first drive mechanism and a filter gripper drivenly connected to the first drive mechanism. The first drive mechanism is disposed on the support frame and is used to drive the filter gripper to clamp the filter sleeve column. The pressure regulating mechanism is used to connect to the filter sleeve column and adjust the air pressure inside the filter sleeve column to filter the sample inside the filter sleeve column.

18. The sample processing system according to claim 17, characterized in that: The filter module also includes an adapter, which is disposed on the support frame and located above the filter clamps. One end of the adapter is connected to the pressure regulating mechanism, and the other end of the adapter is used for a sealed connection with the filter sleeve column. The adapter has a first channel for connecting the filter sleeve and the pressure regulating mechanism.

19. The sample processing system according to claim 18, characterized in that: The pressure regulating mechanism includes a positive pressure component and a pressure relief component; one end of the pressure relief component is connected to the first channel and the other end is connected to the atmospheric environment, and the pressure relief component is used to relieve pressure on the filter sleeve when the adapter is connected to the filter sleeve; one end of the positive pressure component is connected to the first channel and the other end is connected to the air source, and the positive pressure component is used to pressurize the filter sleeve.

20. The sample processing system according to claim 19, characterized in that: The pressure regulating mechanism also includes a negative pressure component, which is connected to the first channel. The negative pressure component is used to create a negative pressure inside the filter sleeve column.

21. The sample processing system according to claim 18, characterized in that: The filter module further includes a second liquid addition module, one end of which is connected to a solvent bottle and the other end of which is connected to the adapter. The second liquid addition module is used to deliver a second target liquid into the filter sleeve column. The adapter also has a second channel for connecting the filter sleeve column and the second liquid addition module.

22. The sample processing system according to claim 18, characterized in that: The filter module further includes a second lifting mechanism, which is disposed on the support frame. The filter module is driven to be connected to the second lifting mechanism, and the second lifting mechanism is used to drive the filter module to lift. and / or The filter module also includes a third lifting mechanism, which is disposed on the support frame. The adapter is driven to connect with the third lifting mechanism, and the third lifting mechanism is used to drive the adapter to move closer to or away from the filter gripper.

23. The sample processing system according to claim 17, characterized in that: The filtration module further includes a base and a placement rack located on the base, the placement rack having at least one first placement position for placing a collection bottle; The filtration module further includes a second translation mechanism and / or a third translation mechanism. The base is disposed on the second translation mechanism, which drives the base to move along a fourth direction so that the collection bottle on the placement rack moves closer to or away from the filter gripper. The third translation mechanism is disposed on the support frame and connected to the filtration module. The third translation mechanism drives the filtration module to move along a fifth direction so that the filter gripper moves closer to or away from the collection bottle. The fourth direction is parallel or perpendicular to the fifth direction.

24. The sample processing system according to claim 23, characterized in that: The filter module also includes a fixing clamping component disposed on the base; The fixed clamping assembly includes a second driving mechanism and a fixed clamping claw driven by the second driving mechanism. The second driving mechanism is used to drive the fixed clamping claw to clamp the filter sleeve column. The fixed clamping claw cooperates with the filter clamping claw or the conveying mechanism to detach the test tube and the connector from the first tube body.

25. The sample processing system according to claim 23, characterized in that: The filter sleeve also includes a plug, which is detachably connected to the end of the second tube away from the first tube. The plug is used to seal the second opening before filtration. The filter module also includes an unloading component located below the filter gripper, which is used to separate the plug from the second tube body.

26. The sample processing system according to claim 25, characterized in that: The placement rack is also provided with at least one second placement position for placing the filter head; after the unloading component removes the plug, the filter gripper drives the filter sleeve to grab the filter head.

27. The sample processing system according to claim 26, characterized in that: The filtering module also includes a recycling component disposed on the base, and the unloading component is located above the recycling component; The filtering module also includes a detector disposed on the base, the detector being used to detect whether the filter sleeve has pierced the filter head.

28. The sample processing system according to claim 23, characterized in that: The sample processing system also includes a marking machine, which is used to mark the collection bottle and / or the test tube.

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