Pressure type medical gauze and preparation method thereof

Abstract

The invention relates to pressure type medical gauze and a preparation method thereof, and belongs to the technical field of gauze. The medical gauze is prepared by interweaving long stapled cotton threads and plant-based herbal medicine fiber threads in a warp and weft mode; the plant-based herbal medicine fiber lines are formed by blending medicine-soaked long stapled cotton fibers and plant-based herbal medicine fibers; the medicine-soaked long stapled cotton fibers are prepared by soaking long stapled cotton fibers into a herbal medicine extracting solution, and the plant-based herbal medicine fibers are prepared by processing solids screened out when the herbal medicine extracting solution is prepared. The dual functions of physical compression and herbal medicine nursing are achieved, hemostasis is assisted and venous return is promoted through the pressure performance, hemostasis, anti-inflammation and wound healing promotion are achieved through herbal medicine components, external medicine does not need to be additionally matched, it is ensured that the herbal medicine components are firmly attached to fibers and are not prone to loss through the technologies of pressure medicine soaking, precise drying and the like, and the application range is wide. And the problems that the traditional external-use herbal medicine is easy to fall off and the drug effect is short in duration are solved.

Description

Technical Field

[0001] This invention belongs to the field of gauze technology, specifically relating to a pressure-type medical gauze and its preparation method. Background Technology

[0002] Traditional medical gauze is only used to cover wounds and absorb exudate, with no additional clinical auxiliary functions. Hemostasis and anti-inflammation require the use of topical medications. Its core function is limited to physical protection and basic fluid absorption. Specifically, in clinical applications, it can only serve as a "physical barrier" for the wound, covering it to prevent the invasion of external contaminants such as dust and bacteria, while absorbing secretions such as blood and tissue fluid from the wound, keeping the wound area dry and clean, and providing a basic clean environment for wound healing.

[0003] When a wound exhibits an inflammatory reaction, with symptoms such as redness, swelling, and purulent discharge, traditional gauze cannot inhibit bacterial growth or alleviate the inflammatory response. It must be used in conjunction with topical antibacterial ointments, anti-inflammatory dressings, and other medications to control the development of inflammation and prevent wound infection. Summary of the Invention

[0004] The purpose of this invention is to provide a pressure-type medical gauze and its preparation method in order to solve the above-mentioned problems.

[0005] The present invention achieves the above objectives through the following technical solutions: This invention provides a pressure-type medical gauze, which is made by interlacing long-staple cotton yarn and plant-based herbal fiber yarn through warp and weft; the plant-based herbal fiber yarn is made by blending drug-impregnated long-staple cotton fiber and plant-based herbal fiber; the drug-impregnated long-staple cotton fiber is made by impregnating long-staple cotton fiber with herbal extract, and the plant-based herbal fiber is made by processing the solids screened out during the preparation of herbal extract.

[0006] The raw materials for preparing the herbal extract, by weight, include: 15-25 parts of Bletilla striata root, 35-50 parts of Cirsium japonicum whole plant, 10-25 parts of Plantago asiatica whole plant, 8-16 parts of Portulaca oleracea whole plant and 20-30 parts of Rubia cordifolia whole plant.

[0007] As a further optimization of the present invention, the preparation process of the herbal extract is as follows: (i) clean the tuberous roots of Bletilla striata, the whole plant of Cirsium japonicum, the whole plant of Plantago asiatica, the whole plant of Portulaca oleracea and the whole plant of Rubia cordifolia, remove the soil and withered leaves, and dry them in a cool place to obtain the herbal material. After drying, the herbal material is pounded for 20-25 minutes using a pounder with an impact energy of 2.0kJ and a pounding frequency of 40bpm. The solid-liquid mixture is then collected. The solid-liquid mixture was repeatedly washed with 65℃ hot water for 30 minutes. The solid was then sieved out through a 60-mesh sieve. The solid and liquid were stored separately. Sodium carboxymethyl cellulose at a weight ratio of 15% of the liquid was added to the liquid. The mixture was stirred at 65r / min for 60-80 minutes to obtain the pre-prepared liquid. (iv) Add 90% ethanol at a weight ratio of 32% to the pre-prepared liquid, let it stand for 45 minutes to settle, remove the supernatant and leave the precipitate, add the same mass of deionized water as the removed supernatant to the precipitate, mix well and obtain the plant extract.

[0008] As a further optimization of the present invention, (I) the solid material sieved through a 60-mesh sieve is placed in a clean container and rinsed with warm water at 35-40℃ 2-3 times. After each rinse, it is left to stand for 5 minutes, and the turbid water on the top layer is poured off to remove the fine medicinal residue, residual extract and a small amount of impurities attached to the surface of the solid material. After rinsing, the solid material is spread flat on a clean tray and placed in a cool and ventilated place to drain the surface water to obtain pretreated solid medicinal material. (ii) Place the pretreated solid medicinal material into a tamping machine, adjust the tamping parameters: impact energy 1.5kJ, tamping frequency 35bpm, and continue tamping for 15-20 minutes to obtain a fluffy medicinal material. (iii) Take deionized water, add cellulase and neutral protease, stir evenly, adjust the pH of the enzymatic hydrolysate to 6.5-7.0 with citric acid, and control the temperature at 45-50℃ to obtain the enzymatic hydrolysate; (iv) Place the fluffy medicinal material into the enzymatic hydrolysate, with the liquid level 2-3 cm above the material. Keep the temperature constant and stir at 20 r / min for 90-120 min. Stir every 15 min during this period. After the enzymatic hydrolysis is complete, pour the medicinal material and the enzymatic hydrolysate into a centrifuge, adjust the speed to 3000 r / min, centrifuge for 10 min, separate the upper enzymatic hydrolysis waste liquid, collect the lower wet fiber mixture, add 40-45℃ warm water to the wet fiber mixture, stir evenly, and filter with an 80 mesh sieve to remove the small lumps of impurities that have not been completely enzymatically hydrolyzed. Repeat the filtration 2-5 times to obtain clean wet herbal fiber. (v) Spread the clean, wet herbal fiber on a drying tray with a thickness of 1-2 cm, place it in a constant temperature drying oven, and dry it until the fiber moisture content is controlled at 8%-12% to obtain plant-based herbal fiber.

[0009] As a further optimization of the present invention, the amount of cellulase added during the preparation of the enzymatic hydrolysate is 0.3%-0.5% of the weight of the fluffy drug material, and the amount of neutral protease added is 0.1%-0.2% of the weight of the fluffy drug material; the weight ratio of deionized water to fluffy drug material is 1:0.65.

[0010] As a further optimization of the present invention, the preparation process of the soaked long-staple cotton fiber is as follows: (i) the long-staple cotton fiber is placed in a closed constant temperature soaking tank, the pretreated herbal extract is poured in, and the extract is made to completely cover the fiber by 3-5 cm. The soaking tank is closed, the temperature inside the tank is kept at 40-45℃, and the fiber is allowed to soak for 60-90 minutes to complete the initial soaking. After the initial soaking, adjust the gauge pressure inside the soaking tank to 0.1-0.15 MPa, keep the temperature constant, and continue soaking for 30-40 minutes. After soaking, slowly release the pressure inside the soaking tank at a decompression rate of 0.02 MPa / min. After the pressure drops to normal pressure, open the tank door, take out the soaked long-staple cotton fibers, and dry them to obtain soaked long-staple cotton fibers.

[0011] As a further optimization of the present invention, the medicinal long-staple cotton fiber and the plant-based herbal fiber are blended and fed into a blending machine at a weight ratio of 7-8:2-3 to obtain the plant-based herbal fiber yarn.

[0012] This invention also provides a method for preparing pressure-type medical gauze, comprising the following steps: S1, using long-staple cotton yarn as warp yarn and plant-based herbal fiber yarn as weft yarn, controlling the warp density to 220-320 threads / 10cm and the weft density to 200-300 threads / 10cm, with a machine tension of 10-20cN and a machine speed of 150-250r / min, to obtain continuous medical gauze; S2, through cutting, sterilization, degreasing, and rolling, the finished medical gauze is obtained.

[0013] The beneficial effects of this invention are as follows: This invention uses long-staple cotton yarn and plant-based herbal fiber yarn interwoven through warp and weft. The plant-based herbal fiber yarn is made by blending medicinal long-staple cotton fibers and plant-based herbal fibers. The medicinal long-staple cotton fibers are made by soaking long-staple cotton fibers in herbal extract. The plant-based herbal fibers are made by processing the solids screened out during the preparation of the herbal extract. This achieves closed-loop utilization of herbal components: the herbal extract is used to soak the long-staple cotton fibers (to prepare medicinal long-staple cotton fibers), and the solids screened out during extraction are processed into plant-based herbal fibers, achieving zero waste of herbal raw materials. Traditional gauze does not have such a raw material recycling design. Traditional medical gauze is only used to cover wounds and absorb exudate, without any additional clinical auxiliary functions. Hemostasis and anti-inflammation require the use of topical medications. This invention achieves the dual functions of physical compression and herbal care. It assists in hemostasis and promotes venous return through pressure, while the herbal ingredients achieve hemostasis, anti-inflammation, and promote wound healing without the need for additional topical medications. Through processes such as pressure soaking and precise drying, the herbal ingredients are ensured to adhere firmly to the fibers and are not easily lost. It can still exert its efficacy with long-term use, solving the problems of traditional topical herbal medicines being easy to fall off and having a short duration of efficacy. Detailed Implementation

[0014] The present application will now be described in further detail. It should be noted that the following specific embodiments are only used to further illustrate the present application and should not be construed as limiting the scope of protection of the present application. Those skilled in the art can make some non-essential improvements and adjustments to the present application based on the above application content.

[0015] Unless otherwise specified, all methods used in this invention are conventional methods known to those skilled in the art, and all reagents and materials used are commercially available products.

[0016] Example 1: The preparation process of the herbal extract is as follows: 15 parts of Bletilla striata root, 35 parts of Cirsium japonicum whole plant, 10 parts of Plantago asiatica whole plant, 8 parts of Portulaca oleracea whole plant, and 20 parts of Rubia cordifolia whole plant were washed clean, removing soil and withered leaves, and dried in a cool place to obtain herbal material; the dried herbal material was pounded for 20 minutes using a pounder with an impact energy of 2.0 kJ and a pounding frequency of 40 bpm, and the solid-liquid mixture was collected; the solid-liquid mixture was repeatedly washed with 65°C hot water for 30 minutes. The solids were sieved through a 60-mesh sieve and stored separately from the liquid. Sodium carboxymethyl cellulose (15% by weight of the liquid) was added to the liquid and stirred at 65 rpm for 60 minutes to obtain a pre-prepared solution. 90% ethanol (32% by weight of the pre-prepared solution) was added to the pre-prepared solution and allowed to stand for 45 minutes to precipitate. The supernatant was removed and the precipitate was left. Deionized water of the same mass as the removed supernatant was added to the precipitate and mixed evenly to obtain the plant extract. The preparation process of plant-based herbal fiber is as follows: The solid material sieved through a 60-mesh sieve is placed in a clean container and rinsed twice with 35℃ warm water. After each rinse, it is left to stand for 5 minutes. The turbid water on the top layer is poured off to remove the fine medicinal residue, residual extract and a small amount of impurities attached to the surface of the solid material. After rinsing, the solid material is spread flat on a clean tray and placed in a cool and ventilated place to drain the surface water to obtain pretreated solid medicinal material. The pretreated solid medicinal material is placed in a tamping machine and the tamping parameters are adjusted: impact energy 1.5kJ, tamping frequency 35bpm, and tamping is continued for 15 minutes to obtain a fluffy medicinal material. Take deionized water (the weight ratio of deionized water to the fibrous material to be enzymatically hydrolyzed is 1:0.65), add cellulase and neutral protease (the amount of cellulase added during the preparation of the enzymatic hydrolysate is 0.3% of the weight of the fibrous material and the amount of neutral protease added is 0.1% of the weight of the fibrous material), stir evenly, adjust the pH of the enzymatic hydrolysate to 6.5 with citric acid, and control the temperature at 50℃ to obtain the enzymatic hydrolysate; The fluffy medicinal material was placed in the enzymatic hydrolysate, with the liquid level 2 cm above the material. The temperature was kept constant, and the stirring frequency was 20 r / min. Enzymatic hydrolysis was continued for 90 min, with stirring every 15 min during the process. After the enzymatic hydrolysis was completed, the medicinal material and the enzymatic hydrolysate were poured into a centrifuge. The centrifugation speed was adjusted to 3000 r / min and centrifuged for 10 min. The upper enzymatic hydrolysis waste liquid was separated, and the lower wet fiber mixture was collected. 40℃ warm water was added to the wet fiber mixture, and after stirring evenly, it was filtered through an 80-mesh sieve to remove small lumps of impurities that were not completely hydrolyzed. The filtration was repeated twice to obtain clean wet herbal fiber. The clean wet herbal fiber was spread evenly on a drying tray with a thickness of 1 cm and placed in a constant temperature drying oven to dry until the fiber moisture content was controlled at 8%, thus obtaining plant-based herbal fiber. The preparation process of the medicinal long-staple cotton fiber is as follows: the long-staple cotton fiber is placed in a sealed constant temperature medicinal soaking tank, and the pretreated herbal extract is poured in to ensure that the extract completely covers the fiber by 3 cm. The soaking tank is closed, and the temperature inside the tank is maintained at 40℃. The fiber is left to soak for 60 minutes to complete the initial soaking. After the initial soaking, the gauge pressure inside the soaking tank is adjusted to 0.1 MPa, the temperature is kept constant, and the soaking continues for 30 minutes. After the soaking is completed, the pressure inside the soaking tank is slowly released at a decompression rate of 0.02 MPa / min. After the pressure drops to normal pressure, the tank door is opened, the medicinal long-staple cotton fiber is taken out, and dried to obtain the medicinal long-staple cotton fiber. Medicated long-staple cotton fibers and plant-based herbal fibers are blended and spun in a blending machine at a weight ratio of 7:2 to obtain plant-based herbal fiber yarn. Long-staple cotton yarn is used as warp yarn, and plant-based herbal fiber yarn is used as weft yarn. The warp density is controlled at 220 threads / 10cm and the weft density at 200 threads / 10cm. The machine tension is 10cN and the machine speed is 150r / min to obtain continuous medical gauze. The finished medical gauze is obtained by cutting, sterilizing, degreasing, and rolling.

[0017] Example 2: The preparation process of the herbal extract is as follows: 20 parts of Bletilla striata root, 45 parts of Cirsium japonicum whole plant, 15 parts of Plantago asiatica whole plant, 10 parts of Portulaca oleracea whole plant, and 25 parts of Rubia cordifolia whole plant were washed clean, removing soil and withered leaves, and dried in a cool place to obtain herbal material; the dried herbal material was pounded for 22 minutes using a pounder with an impact energy of 2.0 kJ and a pounding frequency of 40 bpm, and the solid-liquid mixture was collected; the solid-liquid mixture was repeatedly washed with 65℃ hot water for 3 minutes. 0 min, sieve out the solids through a 60 mesh sieve, and store the solids and liquids separately. Add sodium carboxymethyl cellulose (15% by weight of the liquid) to the liquid and stir at 65 r / min for 70 min to obtain a pre-prepared solution. Add 90% ethanol (32% by weight of the pre-prepared solution) to the pre-prepared solution, let it stand for 45 min to settle, remove the supernatant and leave the precipitate. Add the same mass of deionized water as the removed supernatant to the precipitate, mix well and obtain the plant extract. The preparation process of plant-based herbal fiber is as follows: The solid material sieved through a 60-mesh sieve is placed in a clean container and rinsed three times with 35°C warm water. After each rinse, it is left to stand for 5 minutes. The turbid water on the top layer is poured off to remove the fine medicinal residue, residual extract and a small amount of impurities attached to the surface of the solid material. After rinsing, the solid material is spread flat on a clean tray and placed in a cool and ventilated place to drain the surface water to obtain pretreated solid medicinal material. The pretreated solid medicinal material is placed in a tamping machine and the tamping parameters are adjusted: impact energy 1.5kJ, tamping frequency 35bpm, and tamping is continued for 18 minutes to obtain a fluffy medicinal material. Take deionized water (the weight ratio of deionized water to the fibrous drug material to be enzymatically hydrolyzed is 1:0.65), add cellulase and neutral protease (the amount of cellulase added during the preparation of the enzymatic hydrolysate is 0.4% of the weight of the fibrous drug material, and the amount of neutral protease added is 0.1% of the weight of the fibrous drug material), stir evenly, adjust the pH of the enzymatic hydrolysate to 6.5 with citric acid, and control the temperature at 47℃ to obtain the enzymatic hydrolysate; The fluffy medicinal material was placed in the enzymatic hydrolysate, with the liquid level 2 cm above the material. The temperature was kept constant, and the stirring frequency was 20 r / min. Enzymatic hydrolysis was continued for 100 min, with stirring every 15 min. After the enzymatic hydrolysis was completed, the medicinal material and the enzymatic hydrolysate were poured into a centrifuge. The speed was adjusted to 3000 r / min, and centrifuged for 10 min. The upper enzymatic hydrolysis waste liquid was separated, and the lower wet fiber mixture was collected. 42℃ warm water was added to the wet fiber mixture, and after stirring evenly, it was filtered through an 80-mesh sieve to remove small lumps of impurities that were not completely hydrolyzed. The filtration was repeated 3 times to obtain clean wet herbal fiber. The clean wet herbal fiber was spread evenly on a drying tray with a thickness of 1.5 cm and placed in a constant temperature drying oven. It was dried until the fiber moisture content was controlled at 10% to obtain plant-based herbal fiber. The preparation process of the medicinal long-staple cotton fiber is as follows: the long-staple cotton fiber is placed in a sealed constant temperature medicinal soaking tank, and the pretreated herbal extract is poured in to ensure that the extract completely covers the fiber by 4 cm. The soaking tank is closed, and the temperature inside the tank is maintained at 42℃. The fiber is allowed to soak for 75 minutes to complete the initial soaking. After the initial soaking, the gauge pressure inside the soaking tank is adjusted to 0.12MPa, and the temperature is kept constant. The soaking continues for 35 minutes. After the soaking is completed, the pressure inside the soaking tank is slowly released at a decompression rate of 0.02MPa / min. After the pressure drops to normal pressure, the tank door is opened, the medicinal long-staple cotton fiber is taken out, and dried to obtain the medicinal long-staple cotton fiber. Medicated long-staple cotton fibers and plant-based herbal fibers are blended and fed into a blending machine at a weight ratio of 7:3 to obtain plant-based herbal fiber yarn. Long-staple cotton yarn is used as warp yarn, and plant-based herbal fiber yarn is used as weft yarn. The warp density is controlled at 260 threads / 10cm and the weft density at 250 threads / 10cm. The machine tension is 15cN and the machine speed is 200r / min to obtain continuous medical gauze. The finished medical gauze is obtained by cutting, sterilizing, degreasing, and rolling.

[0018] Example 3: The preparation process of the herbal extract is as follows: 25 parts of Bletilla striata root, 50 parts of Cirsium japonicum whole plant, 25 parts of Plantago asiatica whole plant, 16 parts of Portulaca oleracea whole plant, and 30 parts of Rubia cordifolia whole plant were washed clean, removing soil and withered leaves, and dried in a cool place to obtain herbal material; the dried herbal material was then pounded for 25 minutes using a pounder with an impact energy of 2.0 kJ and a pounding frequency of 40 bpm, and the solid-liquid mixture was collected; the solid-liquid mixture was repeatedly washed with 65℃ hot water for 3 minutes. 0 min, sieve out the solids through a 60 mesh sieve, and store the solids and liquids separately. Add sodium carboxymethyl cellulose (15% by weight of the liquid) to the liquid and stir at 65 r / min for 80 min to obtain a pre-prepared solution. Add 90% ethanol (32% by weight of the pre-prepared solution) to the pre-prepared solution, let it stand for 45 min to settle, remove the supernatant and leave the precipitate. Add the same mass of deionized water as the removed supernatant to the precipitate, mix well and obtain the plant extract. The preparation process of plant-based herbal fiber is as follows: The solid material sieved through a 60-mesh sieve is placed in a clean container and rinsed three times with 40℃ warm water. After each rinse, it is left to stand for 5 minutes. The turbid water on the top layer is poured off to remove the fine medicinal residue, residual extract and a small amount of impurities attached to the surface of the solid material. After rinsing, the solid material is spread flat on a clean tray and placed in a cool and ventilated place to drain the surface water to obtain pretreated solid medicinal material. The pretreated solid medicinal material is placed in a tamping machine and the tamping parameters are adjusted: impact energy 1.5kJ, tamping frequency 35bpm, and tamping is continued for 20 minutes to obtain a fluffy medicinal material. Take deionized water (the weight ratio of deionized water to the fibrous drug material to be enzymatically hydrolyzed is 1:0.65), add cellulase and neutral protease (the amount of cellulase added during the preparation of the enzymatic hydrolysate is 0.5% of the weight of the fibrous drug material, and the amount of neutral protease added is 0.2% of the weight of the fibrous drug material), stir evenly, adjust the pH of the enzymatic hydrolysate to 7.0 with citric acid, and control the temperature at 50℃ to obtain the enzymatic hydrolysate; The fluffy medicinal material was placed in the enzymatic hydrolysate, with the liquid level 3 cm above the material. The temperature was kept constant, and the stirring frequency was 20 r / min. Enzymatic hydrolysis was continued for 120 min, with stirring every 15 min during the process. After the enzymatic hydrolysis was completed, the medicinal material and the enzymatic hydrolysate were poured into a centrifuge. The centrifugation speed was adjusted to 3000 r / min and centrifuged for 10 min. The upper layer of enzymatic hydrolysis waste liquid was separated, and the lower layer of wet fiber mixture was collected. 45℃ warm water was added to the wet fiber mixture, and after stirring evenly, it was filtered through an 80-mesh sieve to remove small lumps of impurities that were not completely hydrolyzed. The filtration was repeated 5 times to obtain clean wet herbal fiber. The clean wet herbal fiber was spread evenly on a drying tray with a thickness of 2 cm and placed in a constant temperature drying oven to dry until the fiber moisture content was controlled at 12%, thus obtaining plant-based herbal fiber. The preparation process of the medicinal long-staple cotton fiber is as follows: the long-staple cotton fiber is placed in a sealed constant temperature medicinal soaking tank, and the pretreated herbal extract is poured in to ensure that the extract completely covers the fiber by 5 cm. The soaking tank is closed, and the temperature inside the tank is maintained at 45℃. The fiber is left to soak for 90 minutes to complete the initial soaking. After the initial soaking, the gauge pressure inside the soaking tank is adjusted to 0.15 MPa, the temperature is kept constant, and the soaking continues for 40 minutes. After the soaking is completed, the pressure inside the soaking tank is slowly released at a decompression rate of 0.02 MPa / min. After the pressure drops to normal pressure, the tank door is opened, the medicinal long-staple cotton fiber is taken out, and dried to obtain the medicinal long-staple cotton fiber. Medicated long-staple cotton fibers and plant-based herbal fibers are blended and fed into a blending machine at a weight ratio of 8:3 to obtain plant-based herbal fiber yarn. Long-staple cotton yarn is used as warp yarn, and plant-based herbal fiber yarn is used as weft yarn. The warp density is controlled at 320 threads / 10cm and the weft density at 300 threads / 10cm. The machine tension is 20cN and the machine speed is 250r / min to obtain continuous medical gauze. The finished medical gauze is obtained by cutting, sterilizing, degreasing, and rolling.

[0019] Comparative Example 1: The preparation process of the herbal extract was as follows: 20 parts of Bletilla striata root tubers, 45 parts of Cirsium japonicum whole plant, 15 parts of Plantago asiatica whole plant, 10 parts of Portulaca oleracea whole plant, and 25 parts of Rubia cordifolia whole plant were washed clean, removing soil and withered leaves, and dried in a cool place to obtain herbal material; the dried herbal material was then pounded for 22 minutes using a pounder with an impact energy of 2.0 kJ and a pounding frequency of 40 bpm, and the solid-liquid mixture was collected; the solid-liquid mixture was repeatedly washed with 65℃ hot water for 3 minutes. 0 min, sieve out the solids through a 60 mesh sieve, and store the solids and liquids separately. Add sodium carboxymethyl cellulose (15% by weight of the liquid) to the liquid and stir at 65 r / min for 70 min to obtain a pre-prepared solution. Add 90% ethanol (32% by weight of the pre-prepared solution) to the pre-prepared solution, let it stand for 45 min to settle, remove the supernatant and leave the precipitate. Add the same mass of deionized water as the removed supernatant to the precipitate, mix well and obtain the plant extract. The preparation process of the medicinal long-staple cotton fiber is as follows: the long-staple cotton fiber is placed in a sealed constant temperature medicinal soaking tank, and the pretreated herbal extract is poured in to ensure that the extract completely covers the fiber by 4 cm. The soaking tank is closed, and the temperature inside the tank is maintained at 42℃. The fiber is allowed to soak for 75 minutes to complete the initial soaking. After the initial soaking, the gauge pressure inside the soaking tank is adjusted to 0.12MPa, and the temperature is kept constant. The soaking continues for 35 minutes. After the soaking is completed, the pressure inside the soaking tank is slowly released at a decompression rate of 0.02MPa / min. After the pressure drops to normal pressure, the tank door is opened, the medicinal long-staple cotton fiber is taken out, and dried to obtain the medicinal long-staple cotton fiber. Medicated long-staple cotton fibers are blended with long-staple cotton fibers at a weight ratio of 7:3 and fed into a blending machine to produce plant-based herbal fiber yarn. Long-staple cotton yarn is used as warp yarn, and plant-based herbal fiber yarn is used as weft yarn. The warp density is controlled at 260 threads / 10cm and the weft density at 250 threads / 10cm. The machine tension is 15cN and the machine speed is 200r / min to obtain continuous medical gauze. The finished medical gauze is obtained by cutting, sterilizing, degreasing, and rolling.

[0020] Comparative Example 2: The preparation process of the herbal extract was as follows: 20 parts of Bletilla striata root tubers, 45 parts of Cirsium japonicum whole plant, 15 parts of Plantago asiatica whole plant, 10 parts of Portulaca oleracea whole plant, and 25 parts of Rubia cordifolia whole plant were washed clean, removing soil and withered leaves, and dried in a cool place to obtain herbal material; the dried herbal material was then pounded for 22 minutes using a pounder with an impact energy of 2.0 kJ and a pounding frequency of 40 bpm, and the solid-liquid mixture was collected; the solid-liquid mixture was repeatedly washed with 65℃ hot water for 3 minutes. 0 min, sieve out the solids through a 60 mesh sieve, and store the solids and liquids separately. Add sodium carboxymethyl cellulose (15% by weight of the liquid) to the liquid and stir at 65 r / min for 70 min to obtain a pre-prepared solution. Add 90% ethanol (32% by weight of the pre-prepared solution) to the pre-prepared solution, let it stand for 45 min to settle, remove the supernatant and leave the precipitate. Add the same mass of deionized water as the removed supernatant to the precipitate, mix well and obtain the plant extract. The preparation process of the medicinal long-staple cotton fiber is as follows: the long-staple cotton fiber is placed in a sealed constant temperature medicinal soaking tank, and the pretreated herbal extract is poured in to ensure that the extract completely covers the fiber by 4 cm. The soaking tank is closed, and the temperature inside the tank is maintained at 42℃. The fiber is allowed to soak for 75 minutes to complete the initial soaking. After the initial soaking, the gauge pressure inside the soaking tank is adjusted to 0.12MPa, and the temperature is kept constant. The soaking continues for 35 minutes. After the soaking is completed, the pressure inside the soaking tank is slowly released at a decompression rate of 0.02MPa / min. After the pressure drops to normal pressure, the tank door is opened, the medicinal long-staple cotton fiber is taken out, and dried to obtain the medicinal long-staple cotton fiber. The medicinal long-staple cotton fibers are fed into a blending machine and spun to obtain plant-based herbal fiber yarn; Using drug-impregnated long-staple cotton fibers as warp and weft yarns, with a warp density of 260 threads / 10cm and a weft density of 250 threads / 10cm, a machine tension of 15cN, and a machine speed of 200r / min, continuous medical gauze is obtained. The finished medical gauze is obtained by cutting, sterilizing, degreasing, and rolling.

[0021] Comparative Example 3: The preparation process of the herbal extract was as follows: 20 parts of Bletilla striata root tubers, 45 parts of Cirsium japonicum whole plant, 15 parts of Plantago asiatica whole plant, 10 parts of Portulaca oleracea whole plant, and 25 parts of Rubia cordifolia whole plant were washed clean, removing soil and withered leaves, and dried in a cool place to obtain herbal material; the dried herbal material was then pounded for 22 minutes using a pounder with an impact energy of 2.0 kJ and a pounding frequency of 40 bpm, and the solid-liquid mixture was collected; the solid-liquid mixture was repeatedly washed with 65℃ hot water for 30 minutes, and the solids were removed through a 60-mesh sieve. The solids and liquids were sieved out and stored separately. The solids were rinsed three times with 35°C warm water, and allowed to stand for 5 minutes after each rinse. The turbid water on the top layer was poured off to remove the fine residue, residual extract, and a small amount of impurities adhering to the surface of the solids. After rinsing, the solids were spread out on a clean tray and placed in a cool and ventilated place to drain the surface water, thus obtaining pretreated solid medicinal material. The pretreated solid medicinal material was placed in a tamping machine, and the tamping parameters were adjusted as follows: impact energy 1.5kJ, tamping frequency 35bpm, and tamping was continued for 18 minutes to obtain a fluffy medicinal material. Take deionized water (the weight ratio of deionized water to the fibrous drug material to be enzymatically hydrolyzed is 1:0.65), add cellulase and neutral protease (the amount of cellulase added during the preparation of the enzymatic hydrolysate is 0.4% of the weight of the fibrous drug material, and the amount of neutral protease added is 0.1% of the weight of the fibrous drug material), stir evenly, adjust the pH of the enzymatic hydrolysate to 6.5 with citric acid, and control the temperature at 47℃ to obtain the enzymatic hydrolysate; The fluffy medicinal material was placed in the enzymatic hydrolysate, with the liquid level 2 cm above the material. The temperature was kept constant, and the stirring frequency was 20 r / min. Enzymatic hydrolysis was continued for 100 min, with stirring every 15 min. After the enzymatic hydrolysis was completed, the medicinal material and the enzymatic hydrolysate were poured into a centrifuge. The speed was adjusted to 3000 r / min, and centrifuged for 10 min. The upper enzymatic hydrolysis waste liquid was separated, and the lower wet fiber mixture was collected. 42℃ warm water was added to the wet fiber mixture, and after stirring evenly, it was filtered through an 80-mesh sieve to remove small lumps of impurities that were not completely hydrolyzed. The filtration was repeated 3 times to obtain clean wet herbal fiber. The clean wet herbal fiber was spread evenly on a drying tray with a thickness of 1.5 cm and placed in a constant temperature drying oven. It was dried until the fiber moisture content was controlled at 10% to obtain plant-based herbal fiber. Plant-based herbal fibers are fed into a blending machine and spun to obtain plant-based herbal fiber yarn; Plant-based herbal fibers were used as warp and weft yarns, with a warp density of 260 threads / 10cm and a weft density of 250 threads / 10cm, a machine tension of 15cN, and a machine speed of 200r / min to obtain continuous medical gauze. The finished medical gauze is obtained by cutting, sterilizing, degreasing, and rolling.

[0022] Performance testing According to YY / T0331-2006 "Performance Requirements and Test Methods for Degreased Cotton Gauze and Degreased Cotton Viscose Blended Gauze", the water absorption and tensile strength properties of the medical gauze prepared by the methods of Examples 1-3 and Comparative Examples 1-3 were tested, and the test results are shown in Table 1.

[0023] Table 1

[0024] As can be seen from the table above, the medical gauze prepared in Examples 1-3 all meet the standard requirements in terms of sinking time, water absorption, longitudinal tensile strength, and transverse tensile strength. It has excellent water absorption performance and stable and reliable mechanical strength, and can provide pressure when bandaging wounds to slowly reduce wound bleeding. The gauze prepared in Comparative Examples 1-3 had excessive sinking time, insufficient water absorption, and low tensile strength. The comparison shows that the preparation process of the present invention can significantly improve the wettability, water absorption capacity and mechanical strength of medical gauze. The overall performance of the product is significantly better than that of the comparative example, and it is more in line with the clinical use requirements of medical gauze.

[0025] The embodiments described above are merely examples of several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these modifications and improvements all fall within the protection scope of the present invention.

Claims

1. A pressure-type medical gauze, characterized in that, The medical gauze is made by interlacing long-staple cotton yarn and plant-based herbal fiber yarn; the plant-based herbal fiber yarn is made by blending drug-impregnated long-staple cotton fiber and plant-based herbal fiber; the drug-impregnated long-staple cotton fiber is made by impregnating long-staple cotton fiber with herbal extract; and the plant-based herbal fiber is made by processing the solid matter screened out during the preparation of herbal extract. The raw materials for preparing the herbal extract, by weight, include: 15-25 parts of Bletilla striata root, 35-50 parts of Cirsium japonicum whole plant, 10-25 parts of Plantago asiatica whole plant, 8-16 parts of Portulaca oleracea whole plant and 20-30 parts of Rubia cordifolia whole plant.

2. The pressure-type medical gauze according to claim 1, characterized in that, The preparation process of the herbal extract is as follows: (i) Clean the tuberous roots of Bletilla striata, the whole plant of Cirsium japonicum, the whole plant of Plantago asiatica, the whole plant of Portulaca oleracea and the whole plant of Rubia cordifolia, remove the soil and withered leaves, and dry them in a cool place to obtain the herbal material. After drying, the herbal material is pounded for 20-25 minutes using a pounder with an impact energy of 2.0kJ and a pounding frequency of 40bpm. The solid-liquid mixture is then collected. The solid-liquid mixture was repeatedly washed with 65℃ hot water for 30 minutes. The solid was then sieved out through a 60-mesh sieve. The solid and liquid were stored separately. Sodium carboxymethyl cellulose at a weight ratio of 15% of the liquid was added to the liquid. The mixture was stirred at 65r / min for 60-80 minutes to obtain the pre-prepared liquid. (iv) Add 90% ethanol at a weight ratio of 32% to the pre-prepared liquid, let it stand for 45 minutes to settle, remove the supernatant and leave the precipitate, add the same mass of deionized water as the removed supernatant to the precipitate, mix well and obtain the plant extract.

3. The pressure-type medical gauze according to claim 1, characterized in that, The preparation process of the plant-based herbal fiber is as follows: (i) The solid material sieved through a 60-mesh sieve is placed in a clean container and rinsed with warm water at 35-40℃ 2-3 times. After each rinse, it is left to stand for 5 minutes. The turbid water on the top layer is poured off to remove the fine medicinal residue, residual extract and a small amount of impurities attached to the surface of the solid material. After rinsing, the solid material is spread flat on a clean tray and placed in a cool and ventilated place to drain the surface water to obtain the pretreated solid medicinal material. (ii) Place the pretreated solid medicinal material into a tamping machine, adjust the tamping parameters: impact energy 1.5kJ, tamping frequency 35bpm, and continue tamping for 15-20 minutes to obtain a fluffy medicinal material. (iii) Take deionized water, add cellulase and neutral protease, stir evenly, adjust the pH of the enzymatic hydrolysate to 6.5-7.0 with citric acid, and control the temperature at 45-50℃ to obtain the enzymatic hydrolysate; (iv) Place the fluffy medicinal material into the enzymatic hydrolysate, with the liquid level 2-3 cm above the material. Keep the temperature constant and stir at 20 r / min for 90-120 min. Stir every 15 min during this period. After the enzymatic hydrolysis is complete, pour the medicinal material and the enzymatic hydrolysate into a centrifuge, adjust the speed to 3000 r / min, centrifuge for 10 min, separate the upper enzymatic hydrolysis waste liquid, collect the lower wet fiber mixture, add 40-45℃ warm water to the wet fiber mixture, stir evenly, and filter with an 80 mesh sieve to remove the small lumps of impurities that have not been completely enzymatically hydrolyzed. Repeat the filtration 2-5 times to obtain clean wet herbal fiber. (v) Spread the clean, wet herbal fiber on a drying tray with a thickness of 1-2 cm, place it in a constant temperature drying oven, and dry it until the fiber moisture content is controlled at 8%-12% to obtain plant-based herbal fiber.

4. The pressure-type medical gauze according to claim 1, characterized in that, When preparing the enzymatic hydrolysate, the amount of cellulase added is 0.3%-0.5% of the weight of the fluffy drug material, and the amount of neutral protease added is 0.1%-0.2% of the weight of the fluffy drug material; the weight ratio of deionized water to fluffy drug material is 1:0.

65.

5. The pressure-type medical gauze according to claim 1, characterized in that, The preparation process of the soaked long-staple cotton fiber is as follows: (i) Place the long-staple cotton fiber into a closed constant temperature soaking tank, pour in the pretreated herbal extract, ensure that the extract completely covers the fiber by 3-5cm, close the soaking tank, maintain the temperature inside the tank at 40-45℃, and let it stand and soak for 60-90min to complete the initial soaking. (ii) After the initial soaking, adjust the gauge pressure inside the soaking tank to 0.1-0.15 MPa, keep the temperature constant, and continue soaking for 30-40 minutes. After the soaking is completed, slowly release the pressure inside the soaking tank at a decompression rate of 0.02 MPa / min. After the pressure drops to normal pressure, open the tank door, take out the soaked long-staple cotton fibers, and dry them to obtain soaked long-staple cotton fibers.

6. The pressure-type medical gauze according to claim 1, characterized in that, The medicated long-staple cotton fiber and plant-based herbal fiber are blended and fed into a blending machine at a weight ratio of 7-8:2-3 to obtain plant-based herbal fiber yarn.

7. A method for preparing the pressure-type medical gauze according to any one of claims 1-6, characterized in that, Includes the following steps: S1, using long-staple cotton yarn as warp yarn and plant-based herbal fiber yarn as weft yarn, controlling the warp density to 220-320 threads / 10cm and the weft density to 200-300 threads / 10cm, with a machine tension of 10-20cN and a machine speed of 150-250r / min, to obtain continuous medical gauze; S2, through cutting, sterilization, degreasing, and rolling, the finished medical gauze is obtained.

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