Waste liquid collecting assembly, sampling equipment and sampling reaction device

Abstract

The invention discloses a waste liquid collecting assembly, sampling equipment and a sampling reaction device. According to the present invention, the waste liquid collection assembly comprises: a support frame, the support frame is provided with a bearing plate, and the bearing plate is provided with a first hole; a sampling tube or a sample in the sampling tube passes through the first hole; the waste liquid collecting container is movably arranged on the bearing plate and used for collecting waste liquid in the sampling pipe, and the waste liquid collecting container can avoid the first hole when moving to a preset position. Compared with the prior art, waste liquid can be conveniently collected, operation is convenient, cost is saved, and efficiency is improved.

Description

Technical Field

[0001] This invention relates to the field of experimental equipment technology, and in particular to a waste liquid collection component, sampling equipment, and sampling reaction device. Background Technology

[0002] With the development of bio-fermentation, multiple sampling is often required to monitor the reaction process and detect parameters. During sampling, reaction reagents remain in the sampling tube after each sample is taken. These residues must be completely removed before subsequent sampling, and the sampling tube and needle must be cleaned; otherwise, the sample detection results will be affected. However, current technologies have limited research on the discharge and collection of excess waste liquid and cleaning fluid from the sampling tube. These waste liquids are typically not specifically collected within the reaction apparatus; instead, an additional container is used for manual collection when necessary.

[0003] For example, Chinese patent document CN208420441U discloses a quantitative sampling device for a reaction vessel that only has a sampling device and no waste liquid collection device.

[0004] Chinese patent document CN218674376U discloses a liquid collection device and sampling equipment. In this sampling equipment, a drive component is connected to a collection tube seat. Under the action of the drive component, the collection tube seat can move horizontally, driving the waste liquid collection container and the sample collection container to move horizontally as well. This device is only suitable for single sampling. If multiple sampling is required, the sample collection container on the collection tube seat needs to be replaced. Manual replacement requires high labor costs, while mechanical replacement requires the design of a special mechanical structure.

[0005] Chinese patent document CN115072086B discloses a rotary automated sampling device. In this device, the reagent bottle serves as both a sampling bottle and a waste bottle, and any excess sample after sampling requires an additional sampling bottle. Although this patent enables multiple samplings, it lacks a waste liquid collection component for easy collection of waste liquid.

[0006] Based on the above problems, there is an urgent need to provide a device that is easy to operate and facilitates the collection of waste liquid. Summary of the Invention

[0007] The purpose of this invention is to provide a waste liquid collection component, sampling equipment, and sampling reaction device, which facilitates waste liquid collection, is easy to operate, saves costs, and improves efficiency.

[0008] To address the aforementioned technical problems, embodiments of the present invention provide a waste liquid collection assembly, comprising:

[0009] A support frame having a receiving plate with a first hole; the first hole is for a sampling tube or a sample in the sampling tube to pass through.

[0010] A waste liquid collection container is movably mounted on the receiving plate for collecting waste liquid from the sampling tube, and the waste liquid collection container can avoid the first hole when it is moved to a preset position.

[0011] In one embodiment, the receiving plate has an elongated hole, and the waste liquid collection container includes: a container body and a connector connected to the container body; the connector passes through the elongated hole and is movable along the extension direction of the elongated hole.

[0012] In one embodiment, the bottom of the container body is provided with a waste liquid discharge hole, and the connector is provided with a waste discharge channel communicating with the waste liquid discharge hole;

[0013] The waste liquid collection assembly further includes a drain pipe connected to the connector, and the drain pipe is connected to the waste discharge channel.

[0014] In one embodiment, the waste liquid collection assembly further includes: a movable plate connected to the connector, and a first driving member, the first driving member being used to drive the movable plate to slide the waste liquid collection container along the extension direction of the elongated hole.

[0015] In one embodiment, the support frame further includes: a support plate connected to the receiving plate, the support plate extending toward the receiving port of the waste liquid collection container;

[0016] A placement space is formed between the support plate and the receiving plate, and the axial direction of the first hole corresponding to the placement space is an empty clearance area.

[0017] In one embodiment, the support plate is a vertical plate, the receiving plate is a horizontal plate, and the support plate and the horizontal plate are vertically connected.

[0018] The line of intersection between the support plate and the cross plate is parallel to the extension direction of the elongated hole.

[0019] In one embodiment, the waste liquid collection container has a first limiting guide, and the receiving plate has a second limiting guide; both the first limiting guide and the second limiting guide are parallel to the extension direction of the elongated hole and cooperate to guide the waste liquid collection container.

[0020] In one embodiment, one of the first limiting guide and the second limiting guide is a guide groove, and the other is a guide rail that mates with the guide groove;

[0021] The waste liquid collection container is provided with a first limiting guide on a pair of side walls that are arranged opposite each other along the direction parallel to the elongated hole.

[0022] The support plate has a functional plate that is positioned toward the first limiting guide, and the second limiting guide is disposed on the functional plate.

[0023] Embodiments of the present invention also provide a sampling device, comprising: a sampling component, a sampling tube, and a waste liquid collection component as described above;

[0024] The sampling assembly includes a sample collection container that is movably moved below the first hole to receive the sample dripping from the sampling tube.

[0025] Embodiments of the present invention also provide a sampling reaction apparatus, comprising: a sampling component, a sampling tube, and a waste liquid collection component as described above, and a reaction vessel having a reaction chamber;

[0026] The sampling assembly includes: a sample collection container, a sampling tube connected to the reaction chamber, and the sample collection container being movable below the first hole to receive the sample dripping from the sampling tube.

[0027] Compared to existing technologies, the waste liquid collection device of this invention, when used in biochemical reaction devices, collects waste liquid discharged from the sampling tube. Because the waste liquid collection container is movably mounted on the receiving plate, it can be moved below the sampling tube to collect the waste liquid. After collection, it can be removed to prevent obstruction of the first orifice, allowing new samples from the sampling tube to pass smoothly through it. This facilitates more convenient collection of waste liquid from the sampling tube, saves costs, and improves work efficiency. This invention is adaptable to various sampling devices, is highly practical, stable, efficient, and suitable for industrial production. Attached Figure Description

[0028] One or more embodiments are illustrated by way of example with reference numerals in the accompanying drawings. These illustrations do not constitute a limitation on the embodiments. Elements with the same reference numerals in the drawings are denoted as similar elements. Unless otherwise stated, the figures in the drawings are not to be limited by scale.

[0029] Figure 1 This is a schematic diagram of the waste liquid collection component in the first embodiment of the present invention;

[0030] Figure 2 This is a perspective view of the waste liquid collection container in the first embodiment of the present invention;

[0031] Figure 3 This is a schematic diagram of the structure of the waste liquid collection component and the sample collection container in the first embodiment of the present invention;

[0032] Figure 4 This is a schematic diagram of the sampling component in the second embodiment of the present invention;

[0033] Figure 5 This is an exploded view of the sample collection container, sampling plate, and placement plate in the sampling assembly of the second embodiment of the present invention;

[0034] Figure 6 This is a schematic diagram of the sampling device in the third embodiment of the present invention;

[0035] Figure 7 This is a schematic diagram of the reactor structure in the fourth embodiment of the present invention;

[0036] Figure 8 This is a schematic diagram of the connecting plate and connecting column in the fourth embodiment of the present invention;

[0037] Figure 9 This is a schematic diagram of the structure of an optional sampling plate in the second embodiment of the present invention;

[0038] Figure 10 This is a schematic diagram of the structure of an optional placement plate in the second embodiment of the present invention;

[0039] Figure 11 This is a schematic diagram of the structure of an optional reaction vessel in the fourth embodiment of the present invention;

[0040] Explanation of reference numerals in the attached drawings: 100, waste liquid collection assembly; 1, support frame; 11, receiving plate; 111, first hole; 112, elongated hole; 12, support plate; 13, placement space; 15, second limiting guide; 16, functional plate; 2, waste liquid collection container; 21, container body; 211, bottom surface; 212, waste liquid discharge hole; 213, receiving interface; 22, connector; 221, waste discharge channel; 23, first limiting guide; 3, moving plate; 401, first driving component; 101, drain pipe; 200, sampling assembly; 5, sampling plate; 51, receiving tank; 52, protrusion; 6, placement plate; 61, groove; 62, first tank wall; 7, driving component. 71. Motor; 72. Lead screw; 73. Mounting base plate; 8. Mounting seat; 91. Transmitter; 92. Sensor; 900. Sample collection container; 300. Sampling equipment; 301. Sampling tube; 302. Fixing plate; 303. Second driving component; 304. Fixing frame; 400. Reactor; 410. Reactor body; 412. Bottom flange; 413. Bottom valve; 420. Reactor cover; 430. Connecting column; 440. Connecting plate; 441. Groove; 450. Cylinder; 451. Cylinder shaft; 452. Guide rod; 460. Stirring power component; 470. Base; 471. First plate; 472. Second plate; 480. Stand. Detailed Implementation

[0041] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the various embodiments of the present invention will be described in detail below with reference to the accompanying drawings. However, those skilled in the art will understand that many technical details have been presented in the various embodiments of the present invention to enable the reader to better understand this application. However, the technical solutions claimed in this application can be implemented even without these technical details and various changes and modifications based on the following embodiments.

[0042] In the following description, certain specific details are set forth for the purpose of illustrating various disclosed embodiments in order to provide a thorough understanding of the various disclosed embodiments. However, those skilled in the art will recognize that embodiments may be practiced without one or more of these specific details. In other instances, well-known apparatuses, structures, and techniques associated with this application may not have been shown or described in detail to avoid unnecessarily obscuring the description of the embodiments.

[0043] Unless the context requires otherwise, throughout the specification and claims, the word “comprising” and its variations, such as “including” and “having”, shall be understood to have an open, inclusive meaning, that is, to be interpreted as “including, but not limited to”.

[0044] The embodiments of the present invention will be described in detail below with reference to the accompanying drawings to provide a clearer understanding of the purpose, features, and advantages of the present invention. It should be understood that the embodiments shown in the drawings are not intended to limit the scope of the present invention, but are merely illustrative of the essential spirit of the technical solution of the present invention.

[0045] Throughout this specification, references to "an embodiment" or "an embodiment" indicate that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment. Therefore, the appearance of "in an embodiment" or "an embodiment" in various places throughout the specification does not necessarily refer to the same embodiment. Furthermore, a particular feature, structure, or characteristic may be combined in any manner in one or more embodiments.

[0046] The singular forms “a” and “the” used in this specification and the appended claims include plural references unless otherwise expressly stated herein. It should be noted that the term “or” is generally used to mean “and / or” unless otherwise expressly stated herein.

[0047] In the following description, in order to clearly demonstrate the structure and working method of the present invention, a number of directional terms will be used. However, terms such as "front", "back", "left", "right", "outside", "inside", "outward", "inward", "up", and "down" should be understood as convenient terms and not as limiting terms.

[0048] Embodiments of the present invention are described below with reference to the accompanying drawings.

[0049] The first embodiment of the present invention relates to a waste liquid collection assembly 100. For example... Figure 1 , Figure 2 As shown, the waste liquid collection assembly 100 includes a support frame 1 and a waste liquid collection container 2. The support frame 1 has a receiving plate 11, on which a first hole 111 is formed, through which the sampling tube 301 or the sample in the sampling tube 301 passes. The waste liquid collection container 2 is movably mounted on the receiving plate 11 for collecting waste liquid in the sampling tube 301, and when the waste liquid collection container 2 is moved to a preset position, it can avoid the first hole 111.

[0050] Specifically, the vertical axis of the first hole 111 coincides with the vertical axis of the sampling tube 301, allowing the liquid in the sampling tube 301 to directly pass through the first hole 111 into the sample collection container 900 of the sampling assembly 200, or to pass through the first hole 111 into the sample collection container 900 during downward movement. Understandably, in other embodiments, the vertical axis of the first hole 111 may not coincide with the vertical axis of the sampling tube 301, as long as the liquid in the sampling tube 301 can enter the sample collection container 900. Understandably, in this embodiment and other embodiments, the waste liquid in the sampling tube includes residual waste sample and waste liquid from cleaning the sampling tube.

[0051] Since the waste liquid collection container 2 is movably mounted on the receiving plate 11, the waste liquid collection container 2 can be moved to collect the waste liquid in the sampling tube 301 below the sampling tube 301. After collection, it can be moved away so as not to block the first hole 111, allowing the new sample in the sampling tube 301 to pass smoothly through the first hole 111. This makes it easier to collect the waste liquid in the sampling tube 301, saving costs and improving work efficiency.

[0052] In addition, such as Figure 1 As shown, the receiving plate 11 has an elongated hole 112. The waste liquid collection container 2 includes a container body 21 and a connector 22 connected to the container body 21. The connector 22 passes through the elongated hole 112 and is movably disposed along the extension direction of the elongated hole 112. When the waste liquid collection container 2 is moved, the connector 22 moves along the elongated hole 112, that is, the container body 21 moves along the elongated hole 112. A perpendicular line drawn from the center of the first hole 111 to the long side of the elongated hole 112 intersects the elongated hole 112, and the intersection point is near one end of the elongated hole 112. The connector 22 restricts and controls the direction of movement of the waste liquid collection container 2, and at the same time, to a certain extent, prevents displacement of the container body 21 due to stirring during the reaction.

[0053] In addition, such as Figure 1 , Figure 2As shown, the bottom of the container body 21 has a waste liquid discharge hole 212, and the connector 22 has a waste discharge channel 221 that communicates with the waste liquid discharge hole 212. The waste liquid collection assembly 100 also includes a drain pipe 101 that is connected to the connector 22 and communicates with the waste discharge channel 221. A valve can be provided on the drain pipe 101. When it is necessary to discharge the waste liquid in the waste liquid collection container 2, the valve can be opened and the waste liquid in the waste liquid collection container 2 can be discharged through the drain pipe 101. The container body 21 only needs to be very small to achieve the collection of a large amount of waste liquid, and there is no need to disassemble the waste liquid collection container 2. Optionally, the diameter of the waste liquid discharge hole 212 is, for example, 3mm-6mm. During the research and development process, it was found that if the diameter of the waste liquid discharge hole 212 is too small, the liquid discharge speed is slow. Within this diameter range, it is suitable for liquid discharge. In other embodiments, the waste liquid discharge hole 212 and the connector 22 can also be respectively set in different areas of the container body 21.

[0054] Furthermore, such as Figure 1 , Figure 2 As shown, the bottom surface 211 of the waste liquid collection container 2 is an inclined or curved surface, and the bottom surface 211 of the waste liquid collection container 2 has a waste liquid discharge hole 212, which is located at the lowest point of the bottom surface of the waste liquid collection container 2. With the waste liquid discharge hole 212 at the lowest point, and through the design of the bottom surface 211 of the waste liquid collection container 2 being an inclined or curved surface, the waste liquid collects at the bottom of the waste liquid collection container 2, making the volume of waste liquid collected in the waste liquid collection container 2 readily apparent. This facilitates the use of the component and also facilitates the discharge of waste liquid.

[0055] In addition, all four sides of the waste liquid collection container 2 are inclined surfaces that slope inwards into the tank, which prevents waste liquid from splashing onto the sides of the waste liquid collection container 2 and causing it to stagnate or splash, thereby preventing contamination of the equipment.

[0056] Furthermore, such as Figure 1 , Figure 3 As shown, the waste liquid collection assembly 100 further includes: a movable plate 3 connected to the connector 22, and a first driving member 401. The first driving member 401 is used to drive the movable plate 3 to slide the waste liquid collection container 2 along the extension direction of the elongated hole 112. The extension direction of the elongated hole 112 is the length direction of the elongated hole 112, as shown by arrow A in the figure. Specifically, the waste liquid collection assembly 100 can be installed on the mounting base plate 73. The movable plate 3 is connected to the connector 22 and extends towards the mounting base plate 73. The first driving member 401 can be a drive motor or cylinder, etc., and is set on the mounting base plate 73. The first driving member 401 can be connected to the bottom of the movable plate 3. Activating the first driving member 401 causes the movable plate 3 to move and the connector 22 to move, allowing the waste liquid collection container 2 to move along the extension direction of the elongated hole 112 to the sampling tube 301 to collect the waste liquid in the sampling tube 301, or to move away from the sampling tube 301 and avoid the first hole 111.

[0057] Furthermore, such as Figure 1 , Figure 2 , Figure 3 As shown, the support frame 1 also includes a support plate 12 connected to the receiving plate 11, the support plate 12 extending in a direction away from the receiving interface 213 of the waste liquid collection container 2. A placement space 13 is formed between the support plate 12 and the receiving plate 11, and the axial direction of the first hole 111 corresponding to the placement space 13 is an empty clearance area. Through the arrangement of the support plate 12 and the receiving plate 11, a placement space 13 is provided below the first hole 111 and the elongated hole 112 for placing other components, while the existence of the clearance area prevents the sample or sampling needle from being interfered with by other components when it falls.

[0058] More importantly, such as Figure 1 As shown, the support plate 12 is a vertical plate, and the receiving plate 11 is a horizontal plate. The support plate 12 and the horizontal plate are perpendicularly connected. The intersection line of the support plate 12 and the horizontal plate is parallel to the extension direction of the elongated hole 112. The vertical plate and the horizontal plate intersect perpendicularly and are fixed in a T-shape or an inverted L-shape. The first hole 111 and the elongated hole 112 are both set on the horizontal plate, and there is a certain distance between the first hole 111 and the elongated hole 112. Space needs to be left below the first hole 111 for the sample collection container 900 to move and perform multiple samplings. Space is left below the elongated hole 112 for the connecting part 22 that needs to perform reciprocating motion. This embodiment further cleverly designs the first hole 111 and the elongated hole 112 to realize automated multiple sampling and waste liquid collection.

[0059] Furthermore, such as Figure 1 , Figure 2As shown, the waste liquid collection container 2 has a first limiting guide 23, and the receiving plate 11 has a second limiting guide 15. Both the first limiting guide 23 and the second limiting guide 15 are parallel to the extension direction of the elongated hole 112 and cooperate to guide the waste liquid collection container 2. In this embodiment, the first limiting guide 23 can be a guide groove provided on the outer wall surface of the waste liquid collection container 2. The support plate 12 has a functional plate 16 facing the first limiting guide 23, and the second limiting guide 15 can be a guide rail provided on the functional plate 16, with the guide rail embedded in the guide groove. When the waste liquid collection container 2 moves, the movement position of the waste liquid collection container 2 is accurate, while avoiding positional shaking caused by stirring during the reaction. Guide grooves are provided on one outer wall surface of the waste liquid collection container 2, which is parallel to the direction of the elongated hole 112. Two guide rails are also provided, which are embedded in the corresponding guide grooves, that is, the waste liquid collection container 2 is clamped between the two second limiting guides 15. Understandably, in other embodiments, a guide rail and a guide groove may also be provided. Furthermore, either the first limiting guide 23 or the second limiting guide 15 can be a guide rail and the other a guide groove; it is not limited to the scheme in this embodiment. Using the waste liquid collection assembly 100 in this embodiment, after a single sampling is completed, the first driving member 401 simultaneously controls the waste liquid collection container 2 to move towards the first hole 111. When it moves below the sampling tube 301, any excess sample in the sampling tube 301 can be directly discharged into the waste liquid collection container 2. When a second sampling is required, the first driving member 401 controls the waste liquid collection container 2 to move away from the first hole 111, exposing the first hole 111. The sampling tube 301 can directly discharge the sample into the corresponding sample collection container 900 or move downwards and pass through the first hole 111 to insert into the sample collection container 900, controlling the pump to perform sampling. After sampling is completed, the above operation of discharging excess sample into the waste liquid collection container 2 is repeated. After all sampling is completed, the sampling tube 301 and its connected pipes are rinsed, and the corresponding waste liquid is discharged into the waste liquid collection container 2, thus automating the collection of waste liquid and the cleaning of the sampling tube 301. After the waste discharge is completed, the liquid in the waste liquid collection container 2 needs to be drained. The drain pipe 101 at the bottom of the waste liquid collection container 2 can be opened to drain the liquid from the waste liquid collection container 2.

[0060] The device in this embodiment achieves convenient control of waste discharge after sampling in biocatalytic reactions. It features a compact structure, simple waste discharge steps, and does not affect subsequent sampling experiments. The device is easy to operate, highly practical, and has high production efficiency. Its compact structure and convenient installation and maintenance make it suitable for industrial production. Compared to traditional waste discharge processes, this embodiment primarily controls the movement of the waste collection container 2 to discharge the waste liquid from the sampling tube 301. After waste discharge, the waste collection container 2 can be moved independently without affecting subsequent sampling operations. The waste collection container 2 in this device can be controlled independently and combined with various sampling structures, making it convenient and easy to operate. In this embodiment, a horizontal plate is used to suspend the waste collection container 2 at a corresponding position below the sampling tube 301, thus fixing the waste collection container 2 without requiring manual support. When it is necessary to discharge the waste liquid from the waste collection container 2, it can be directly discharged through the drain pipe 101. The movement of the waste liquid collection container 2 is stable, and the internal liquid discharge will not cause stagnation or splashing, thereby preventing equipment contamination. Moreover, all operations can be performed mechanically, which improves the degree of automation and saves manpower.

[0061] A second embodiment of the present invention relates to a sampling component 200. For example... Figure 4 , Figure 5 As shown, the sampling assembly 200 includes a sampling plate 5 and a placement plate 6. A receiving groove 51 is formed on the top of the sampling plate 5 for placing a sample collection container 900. Multiple receiving grooves 51 are arranged in a straight line along the length of the sampling plate 5. In other embodiments, there may be one receiving groove 51, or multiple receiving grooves 51 may have other arrangements as needed.

[0062] Furthermore, outside the receiving groove 51, the top of the sampling plate 5 is provided with a protrusion 52, and the protrusion 52 is located in the middle area along the length direction of the sampling plate 5. The middle area can be the middle of the length direction of the sampling plate 5, i.e., the direction indicated by arrow C, or slightly off-center, as long as it is convenient for the robotic arm to grasp the protrusion 52 and stably pick up the sampling plate 5 during use. The top of the placement plate 6 is provided with a groove 61 for receiving the sampling plate 5, and when the sampling plate 5 is placed in the placement plate 6, the protrusion 52 is at least partially located outside the placement plate 6. The height of the protrusion 52 protruding from the top of the sampling plate 5 is such that it can be grasped by the robotic arm. Of course, the height of the protrusion 52 can also be set according to actual usage requirements. In this embodiment, the robotic arm can directly grasp the protrusion 52 located in the middle area along the length direction of the sampling plate 5 to the next reaction point. The grasping process is stable, and at the same time, the sampling plate 5 and the lower part of the groove 61 of the placement plate 6 are tightly nested together, and friction prevents the sampling plate 5 from moving. Understandably, the sampling plate 5 can be grasped not only by a robotic arm but also by other means, such as by hand.

[0063] In other embodiments, the sampling plate may optionally be as follows: Figure 9 As shown, the placement plate can optionally be as follows: Figure 10 As shown, the protrusion in the middle of the sampling plate is not on top of the sampling plate, but on both sides. This is to cooperate with the structure on both sides of the placement plate to fix the sampling plate. This structure requires precise positioning by the robotic arm to accurately place the sample when gripping and placing it. Moreover, when gripping, it is necessary to lift it upward first and then move it in the corresponding direction. Furthermore, the gripper of this sampling plate is at one end of the sampling plate. When the robotic arm grips the gripper of the sampling plate, an additional force is required to control the balance, which is not suitable for subsequent automated operation.

[0064] Furthermore, such as Figure 5 As shown, protrusions 52 are disposed opposite to each other on both sides of the sampling plate 5 along the width direction of the sampling component 200. Understandably, there can be multiple protrusions 52; for example, multiple protrusions can be disposed on both length sides of the sampling plate 5, or one protrusion can be disposed on each length side of the sampling plate 5. In other embodiments, the protrusions 52 can also be disposed integrally on the sampling component 200.

[0065] Furthermore, such as Figure 5 As shown, the groove 61 has a pair of opposing first groove walls 62, which extend along the length of the sampling plate 5, and the shortest distance between the pair of first groove walls 62 is equal to the width of the sampling plate 5.

[0066] Furthermore, such as Figure 5 As shown, the distance between the pair of first groove walls 62 gradually decreases from top to bottom, and the distance between the tops of the pair of first groove walls 62 is greater than the width of the sampling plate 5. That is to say, the internal space of the groove 61 is wider at the top and narrower at the bottom, so that the sampling plate 5 can be perfectly embedded in the groove 61. The narrower internal space at the bottom is closely matched with the size of the sampling plate 5 to prevent the sampling plate 5 from moving in the groove 61 through friction. The wider top makes it easy for the robot arm to put it down from above, allowing for smooth and free movement.

[0067] In addition, such as Figure 5 As shown, the groove 61 of the placement plate 6 has an open cross-section at at least one end, which facilitates the robot arm to move the sampling plate 5 directly upwards at an angle. In other embodiments, it can also be closed. When closed, it helps the robot arm to push the sampling plate 5 towards the closed end after it is placed on the placement plate 6, thus determining the position of the sampling plate 5. A suitable placement plate 6 can be selected according to actual operational needs.

[0068] In addition, such as Figure 4 , Figure 5As shown, the sampling assembly 200 further includes a mounting base 8 and a driving device 7. The mounting base 8 supports the placed plate 6, and the driving device 7 drives the mounting base 8 to move the placed plate 6 and the sampling plate 5 along the length direction of the sampling plate 5. Specifically, the driving device 7 includes a lead screw 72 connected to the mounting base 8 and a motor 71 that drives the lead screw 72 to rotate. The lead screw 72 extends along the length direction of the sampling plate 5, and the mounting base 8 moves along the lead screw 72 when the lead screw 72 is driven by the motor 71. The driving device 7 also includes a mounting base plate 73 extending along the extension direction of the lead screw 72, with the lead screw 72 located above the mounting base plate 73. The placement plate 6 is detachably connected to the mounting base 8, which is movably mounted on the lead screw 72. A motor 71 controls the rotation of the lead screw 72. The rotation of the threaded lead screw 72 causes the mounting base 8 on the lead screw 72 to reciprocate linearly on a horizontal plane. The motor 71 controls the movement distance of the mounting base 8. The lead screw 72 is threaded, and its rotation direction is controlled by the coupling of the drive device 7, thereby controlling the movement direction of the mounting base 8. The sampling plate 5 and the sample collection container 900 placed on it can move left and right within the groove 61 along with the mounting base 8 on the lead screw 72. The sampling plate 5 and other components can be detached from the mounting base 8, or the sample collection container 900 can be removed from the sampling plate 5 (e.g., taken away) for cleaning.

[0069] Furthermore, such as Figure 4 , Figure 5 As shown, the sampling assembly 200 also includes an emitter 91 and a sensor 92 that senses the light emitted by the emitter 91. One of the sensor 92 and the emitter 91 is mounted on the mounting base 73, and the other is mounted on the mounting seat 8. The lead screw 72 is a threaded lead screw, which moves by rotating its thread. The number of rotations of the lead screw 72 can be used to determine the moving distance of the mounting seat 8, which is convenient for determining the position of the mounting seat 8 in conjunction with the sensor 92, thereby determining which sample collection container 900 is located below the sampling tube 301. The PLC sends pulses to the drive device 7, and the number of rotations of the motor 71 controls the alignment accuracy between the sample collection container 900 and the sampling tube 301. The mounting seat 8 and the series of components fixed on it can only move left and right on the lead screw 72, and the moving distance is controlled by the motor 71. During the movement of the mounting seat 8, each sample collection container 900 on the sampling plate 5 passes under the sampling tube 301 in sequence, thereby achieving continuous sampling. This, combined with the drive device 7, enables automated continuous sampling.

[0070] The sampling assembly 200 also includes a sample collection container 900. During sampling, the sample collection container 900 is placed in the receiving groove 51 of the sampling plate 5, and the sampling plate 5 containing the sample collection container 900 is moved into the groove 61. The groove 61 containing the sampling plate 5 is detachably fixedly connected to the mounting base 8. The motor 71 controls the lead screw 72 to rotate. After the threaded lead screw 72 rotates, it drives the mounting base 8 on the lead screw 72 to move linearly back and forth on the horizontal plane. The motor 71 moves the sampling plate 5 directly below the sampling tube 301, so that the bottle opening of the first sample collection container 900 is directly facing the sampling tube 301. After the first sample collection container 900 completes sampling, when a second sampling is required, motor 71 controls the second sample collection container 900 in sampling plate 5 to move directly below sampling tube 301 to complete the sampling. This process continues in this manner. During sampling, a transmitter 91 is mounted on the side of lead screw 72, and a sensor 92 is mounted on the side of mounting base 8. These sensors can determine the container's position by sensing light. After sampling, the sample collection container 900 needs to be sent to the next module (e.g., the analysis module) for further processing. A robotic arm can be used to grasp sampling plate 5 for the next operation. Sampling plate 5 is long and narrow, so its sampling sequence can be easily determined. After sample collection container 900 completes its subsequent experiment, the robotic arm grasps sampling plate 5 and places it back into its receiving slot 51, awaiting further experimentation. Motor 71 controls the mounting base 8 to move along the horizontal lead screw 72, enabling the sample collection container 900 to move left and right along the C-direction in both directions, thus achieving automated multiple sampling.

[0071] A third embodiment of the present invention relates to a sampling device 300. For example... Figure 6 As shown, the sampling device 300 includes: the sampling component 200 in the above embodiment and the waste liquid collection component 100 in the above embodiment.

[0072] The specific structures of the sampling component 200 and the waste liquid collection component 100 will not be described in detail here.

[0073] Furthermore, such as Figure 6As shown, the sampling device 300 also includes a sampling tube 301. The sampling tube 301 is connected to the reaction chamber in the reactor, optionally via a flexible hose or directly fixed to the bottom of the reactor to achieve communication with the reaction chamber. Further, it also includes a fixing plate 302, on which the sampling tube 301 passes and is fixed; the fixing plate 302 is preferably a horizontal plate. Further, it also includes a second driving component 303 connected to the fixing plate 302, which drives the fixing plate 302 to rise and fall, thereby driving the sampling tube 301 to rise and fall, enabling automated multiple sampling. The second driving component can be a drive motor or cylinder, etc. Even further, it also includes a fixing frame 304 for fixing the second driving component. The fixing frame 304 is optionally connected to the mounting base plate 73. The mounting bracket 304 includes a vertically placed panel and a vertical plate with a bending structure. The panel is attached and fixed to the second drive motor, and the vertical plate with the bending structure is used to leave space for other components such as the motor, resulting in a compact sampling device 300.

[0074] The fourth embodiment of the present invention relates to a reaction vessel 400. For example... Figure 7 As shown, the reactor 400 includes: a reactor body 410, a reactor lid 420, a connecting column 430, a connecting plate 440, and a cylinder 450. The reactor lid 420 is used to open or close the reactor body 410. The connecting column 430 is connected to the reactor lid 420, and the connecting plate 440 is connected to the end of the connecting column 430 opposite to the reactor lid 420. The cylinder 450 is a shafted cylinder, with its cylinder shaft 451 connected to the connecting plate 440 and used to drive the connecting plate 440 and the connecting column 430 to reciprocate the reactor lid 420 relative to the reactor body 410. In this case, the shaft in the shafted cylinder refers to the piston rod. The cylinder can be a single-shaft cylinder, a double-shaft cylinder, a triple-shaft cylinder, or other multi-shaft cylinders. A single-shaft cylinder has only one piston rod, while a double-shaft cylinder is a combination of two single-shaft cylinders suitable for devices with high load forces. The three-axis cylinder has a piston rod in the middle and two guide rods 452 on both sides. The function of the guide rods 452 is to ensure the linear movement of the piston rod, reduce the shaking and offset of the piston rod, and withstand greater lateral force, making it suitable for high-precision equipment.

[0075] In other embodiments, the structure of the reactor 400 may optionally be as follows: Figure 11 As shown. The reactor body is relatively tall. To simplify the structure, the developers of this invention initially chose a rodless cylinder that matched the overall height of the reactor. Based on this, a long connecting plate was needed to connect the reactor lid and the lifting slider. This connection method meant that the stress point was only at the bend of the long connecting plate, leading to instability during the lifting and lowering of the reactor lid.

[0076] In this embodiment, the vessel lid 420 can slide up and down under the force of the cylinder shaft 451 of the cylinder 450. It can rise to the highest point of the cylinder 450 and cylinder shaft 451, and fall to the highest point of the cylinder body of the cylinder 450. The distance between the plane height of the lid 420 and the plane height of the vessel lid 420 is small. Only a short connecting column 430 is needed to connect the connecting plate 440 to the vessel lid 420, allowing the vessel lid 420 to rise and fall stably without damaging the components on the vessel lid 420 and the vessel body 410. This ensures the sealing of the vessel lid 420 and the vessel body 410, making it convenient to use and enabling automatic raising and lowering of the vessel lid 420. Moreover, when the vessel lid 420 rises to its highest point, the distance between the vessel lid 420 and the vessel body 410 is sufficient for reaction operations such as robotic arm or manual feeding.

[0077] The cylinder 450 has two air valves on its side. The air compressor is connected to the air valves via solenoid valves to control its rise and fall. In this embodiment, when the lid 420 rises to its highest point, the cylinder shaft 451 in the cylinder 450 is not completely detached from the cylinder body. One-third or even more of its length needs to be within the cylinder body to bear the lateral force caused by the gravity of the lid 420 and the connecting plate 440. Therefore, as the enclosing structure, i.e., the cylinder body, becomes longer, the corresponding length of the cylinder shaft 451 also needs to increase.

[0078] Considering that multiple components need to be installed on the vessel lid to achieve purposes such as temperature control, sampling, feeding, pH monitoring and adjustment, and stirring, the lifting and lowering of the vessel lid using a rodless cylinder (i.e., a single slider on a rod) is prone to shaking. Even reducing the force on the slider (e.g., reducing the weight of the long connecting plate or the vessel lid itself) cannot solve the shaking problem. In this embodiment, a shafted cylinder combined with two or more connecting columns ensures that the vessel lid 420 does not shake during lifting and lowering. At the same time, the cleverly designed connecting plate 440 still enables the detection and control of multiple requirements on the vessel lid 420. The axial cylinder, in conjunction with the connecting plate and connecting column, enables convenient control of the smooth lifting and lowering of the vessel lid 420 during the reaction process. This facilitates the opening and closing of the lid 420 and the vessel body 410, improving mechanical stability and preventing swaying during lifting. When the vessel body 410 forms a sealed space, operation is safer and more convenient, reducing collisions between the lid 420 and the vessel body 410. The weight of the lid 420 further strengthens the seal between it and the vessel body 410. The reactor 400 in this example is highly practical, stable, and efficient, extending its service life and making it suitable for industrial production.

[0079] Furthermore, such as Figure 7As shown, there are at least two connecting columns 430, and the connecting columns 430 are equidistantly arranged around the center of the vessel cover 420. Preferably, in this embodiment, the cylinder 450 is a three-axis cylinder, and the cylinder shaft 451 includes a piston rod, with two guide rods 452 located on both sides of the piston rod. Compared with single-axis and double-axis cylinders, the three-axis cylinder can more strictly limit the displacement of the connecting plate 440. Combined with the structure of the connecting plate 440 and the connecting columns 430, the position of the vessel cover 420 will not move even during stirring in the reactor. The cylinder shaft 451 is parallel to the connecting columns 430 and located on the same side of the connecting plate 440. The three-axis cylinder has a built-in buffer and explosion-proof device, which can decelerate the vessel cover 420 when it descends, reducing the collision between the vessel cover 420 and the vessel body 410. The vessel body 410 is relatively tall. The use of a three-axis cylinder eliminates the need for a long connecting plate, avoiding the uneven force distribution on one side of the vessel lid caused by the long connecting plate connection method in existing technologies, which prevents the lid and vessel body from fitting tightly. In this embodiment, the special positioning of the connecting column and connecting plate, combined with the use of the three-axis cylinder, further improves the stability of the lid's lifting and lowering, making the lid 420 lifting smoothly and stably. Furthermore, the connecting column 430 on the lid 420 ensures even force distribution, facilitating operation. It also eliminates the need for a clamping device on the lid 420 to maintain a sealed environment within the reaction chamber and fix the lid's position. In this embodiment, there are two connecting columns 430; however, the number of connecting columns 430 may vary in other embodiments.

[0080] In addition, such as Figure 7 As shown, the stroke of cylinder shaft 451 is greater than or equal to the maximum moving distance between the lid 420 and the vessel body 410. After cylinder shaft 451 controls the lid 420 and the vessel body 410 to be fully engaged, the weight of the lid 420 is fully applied to the vessel body 410, achieving a good sealing effect. Alternatively, when the stroke of cylinder shaft 451 is greater than the maximum moving distance between the lid 420 and the vessel body 410, after cylinder shaft 451 controls the lid 420 and the vessel body 410 to be fully engaged, that is, after the lid 420 covers the vessel body 410, due to the weight of the lid 420, cylinder shaft 451 can continue to descend by relying on the weight of the lid 420. And because the cylinder has not yet completed its stroke, the downward pressure of cylinder shaft 451 is increased on the basis of gravity, so that the weight of the lid 420 is fully applied to the vessel body 410, further sealing the vessel body 410 with the lid 420, resulting in better sealing performance.

[0081] In addition, such as Figure 8 As shown, a slot 441 is opened on the side of the connecting plate 440 away from the cylinder shaft 451, and the slot 441 penetrates the connecting plate 440.

[0082] Furthermore, such as Figure 8As shown, connecting posts 430 are provided on both sides of the slot 441, and the connecting posts 430 on both sides of the slot 441 are respectively connected to the two ends of the diameter of the lid 420.

[0083] In addition, such as Figure 8 As shown, the width of the side of the connecting plate 440 with the slot 441 is greater than the width of the side connecting the cylinder shaft 451. The side of the connecting plate 440 with the slot 441 has a "U" shaped structure.

[0084] In other words, such as Figure 8 As shown, the slot 441 connects to the other end of the connecting column 430 on both sides. The size of the slot 441 allows the functional holes on the lid 420 to pass through and be used normally (sampling, ventilation, and temperature holes are located on the lid below the slot 441). The connecting plate 440 is a horizontal plate, and the width of the other end of the horizontal plate can be reduced, making the entire lid 420 and connecting plate 440 a symmetrical, almost "V"-shaped structure. Reducing the width reduces material consumption and weight, making the vertical movement of the cylinder 450 smoother, and also making the overall appearance more harmonious and aesthetically pleasing. At the same time, it does not affect the lifting stability of the lid 420 and the uniformity of the force on the connecting column 430, and also increases the operable space on the surface of the lid 420. To achieve the purpose of reducing material consumption and weight, the thickness of the lid 420 can also be reduced to 1cm, making the lid 420 thinner, easier to tighten, and reducing material consumption. The connecting plate 440 can be made of steel plate with a thickness of 0.5cm or more to achieve the load-bearing purpose of the lid 420.

[0085] In addition, such as Figure 7 As shown, the reaction vessel 400 also includes a stirring power component 460, which passes through the slot 441 and is fixed to the vessel cover 420. This stirring power component 460 can be, for example, a motor. Further, as... Figure 7 As shown, the reactor 400 also includes a base 470 and a support 480. One side of the support 480 is connected to the cylinder 450, and the other side is connected to the reactor body 410. The support 480 is also connected to the base 470. The bottom of the support 480 extends downward along the bottom of the cylinder 450 and is fixed thereto, so that the cylinder shaft 451 can be lowered to a lower position. The support 480 can be a vertical plate made of steel. It not only needs to fix the cylinder 450 but also needs to support the weight of the reactor body 410. However, the cylinder 450 only has steel around the cylinder shaft 451, and its outer shell structure is made of aluminum alloy. It is lightweight and has low strength, so it cannot be used for fixing.

[0086] Furthermore, such as Figure 7As shown, the base 470 includes: a pair of opposing first plates 471, and a second plate 472 connecting the pair of first plates 471. The support 480 is a vertical plate fixed to the second plate 472. That is, the base 470 is H-shaped, and the support 480 is fixed on the H-shaped base 470. The 'H' shaped structure of the base 470 saves more materials and space, and facilitates the installation of various fluid pipelines, pumps, valves and other accessories required for the operation of the reactor 400 in the empty space near the reactor 400. This also makes the mechanical configuration of the entire reactor 400 equipment more compact and space-saving.

[0087] Specifically, such as Figure 7As shown, a bottom valve 413 is located below the reactor body 410. A sealing ring is installed on the bottom valve 413 to maintain a sealed state. The bottom valve 413 is connected to the bottom flange 412 of the reactor body 410, and controls the discharge of a large amount of waste material after the reaction is complete. The reactor cover 420 may have other holes, such as a stirrer mounting hole, a vision sensor mounting hole, a liquid feeding hole, a pH sensor mounting hole, an acid / base feeding hole, a temperature sensor mounting hole, a dissolved oxygen sensor mounting hole, a pressure sensor mounting hole, and a spare hole. The spare hole is sealed when not in use. A stirring power unit 460 is installed on the stirrer mounting hole to stir the liquid inside the reactor body 410, ensuring a thorough reaction. A camera is installed on the vision sensor, allowing real-time observation of the reaction within the reactor 400. Based on the set requirements for the type and quantity of liquid to be added to the reactor 400, the liquid is pumped into the reactor 400 through the liquid feeding hole via a peristaltic pump and a directional valve. A pH sensor is installed at the pH sensor mounting hole. The pH sensor collects the pH value of the reaction system and controls two peristaltic pumps to add acid or alkali through the acid-base feeding holes, thereby controlling the pH during the biotransformation process. The outer wall of the reactor body 410 is insulated by wrapping it with insulation material. The temperature sensor mounting hole connects to a thermoelectric semiconductor temperature control module (TEC temperature control module) to heat or cool the stainless steel tank wall of the reactor 400 to control the tank temperature. Dissolved oxygen sensor mounting holes and pressure sensor mounting holes ensure a sealed, constant pressure within the tank. If required by the reaction, the dissolved oxygen sensor mounting hole connects to a gas mass flow meter and an electronically controlled proportional valve. The gas mass flow meter collects the gas flow rate, and the electronically controlled proportional valve is activated based on the set value to achieve precise control of the gas flow rate. When using reactor 400, a peristaltic pump is used to inject clean water into the reactor body through the liquid feeding hole of the reactor lid 420 to clean the vessel. The bottom valve 413 is opened to clean and drain the waste liquid inside the reactor. This process can be repeated two or more times. After closing the bottom valve 413, the air compressor is turned on, opening cylinder 450 and causing the reactor lid 420 to rise vertically to its highest point. The reactor lid 420, connected by connecting plate 440, is in the open state, allowing the robotic arm to add solid raw materials. When cylinder 450 is closed, the reactor lid 420 is lowered vertically to its lowest point, closing and sealing tightly against the reactor body 410. The entire experimental process is conducted in a closed environment. The stirring power unit 460 is activated, controlling the peristaltic pump to inject the reaction stock solution through the liquid feeding hole of the reactor lid 420 (the pH value can be automatically adjusted based on pH feedback). The reaction inside the reactor can be observed through the electronic camera in the visual sensor mounting hole on the reactor lid 420.

[0088] The fifth embodiment of the present invention relates to a sampling reaction apparatus, comprising: a reaction vessel 400 having a reaction chamber, a sampling component 200 from the above embodiments, a sampling tube 301, and a waste liquid collection component 100 from the above embodiments. The sampling component 200 includes a sample collection container 900, the sampling tube 301 communicating with the reaction chamber, and the sample collection container 900 being movably movable below the first hole 111 to receive the sample dripping from the sampling tube 301. In this embodiment, the structure of the reaction vessel 400 can be conventional in the art, preferably the reaction vessel 400 of the fourth embodiment above. The sampling component 200, the waste liquid collection component 100, the sampling tube 301, and the reaction vessel 400 have all been described in detail in the above embodiments and will not be described in detail here.

[0089] It is not difficult to see that this embodiment is a system embodiment corresponding to the above embodiments, and this embodiment can be implemented in conjunction with the above embodiments. The relevant technical details mentioned in the above embodiments are still valid in this embodiment, and will not be repeated here to reduce repetition. Accordingly, the relevant technical details mentioned in this embodiment can also be applied to the above embodiments.

[0090] The preferred embodiments of the present invention have been described in detail above, but it should be understood that, if necessary, aspects of the embodiments can be modified to utilize aspects, features, and concepts from various patents, applications, and publications to provide other embodiments.

[0091] In light of the detailed description above, these and other changes can be made to the embodiments. Generally, the terminology used in the claims should not be considered limited to the specific embodiments disclosed in the specification and claims, but should be understood to include all possible embodiments together with the full scope of equivalents enjoyed by these claims.

[0092] Those skilled in the art will understand that the above embodiments are specific embodiments for implementing the present invention, and in practical applications, various changes in form and detail may be made without departing from the spirit and scope of the present invention.

Claims

1. A waste liquid collection assembly, characterized in that, include: A support frame having a receiving plate with a first hole; the first hole is for a sampling tube or a sample in the sampling tube to pass through. A waste liquid collection container is movably mounted on the receiving plate for collecting waste liquid from the sampling tube, and the waste liquid collection container can avoid the first hole when it is moved to a preset position.

2. The waste liquid collection assembly according to claim 1, characterized in that, The receiving plate has an elongated hole, and the waste liquid collection container includes: a container body and a connector connected to the container body; the connector passes through the elongated hole and is movable along the extension direction of the elongated hole.

3. The waste liquid collection assembly according to claim 2, characterized in that, The bottom of the container body is provided with a waste liquid discharge hole, and the connector is provided with a waste discharge channel that communicates with the waste liquid discharge hole. The waste liquid collection assembly further includes a drain pipe connected to the connector, and the drain pipe is connected to the waste discharge channel.

4. The waste liquid collection assembly according to claim 2, characterized in that, The waste liquid collection assembly further includes: a movable plate connected to the connector, and a first driving member, the first driving member being used to drive the movable plate to slide the waste liquid collection container along the extension direction of the elongated hole.

5. The waste liquid collection assembly according to claim 4, characterized in that, The support frame further includes: a support plate connected to the receiving plate, the support plate extending toward the receiving port away from the waste liquid collection container; A placement space is formed between the support plate and the receiving plate, and the axial direction of the first hole corresponding to the placement space is an empty clearance area.

6. The waste liquid collection assembly according to claim 2, characterized in that, The support plate is a vertical plate, the receiving plate is a horizontal plate, and the support plate and the horizontal plate are vertically connected. The line of intersection between the support plate and the cross plate is parallel to the extension direction of the elongated hole.

7. The waste liquid collection assembly according to claim 2, characterized in that, The waste liquid collection container has a first limiting guide, and the receiving plate has a second limiting guide; both the first limiting guide and the second limiting guide are parallel to the extension direction of the elongated hole and cooperate to guide the waste liquid collection container.

8. The waste liquid collection assembly according to claim 7, characterized in that, One of the first limiting guide and the second limiting guide is a guide groove, and the other is a guide rail that mates with the guide groove; The waste liquid collection container is provided with a first limiting guide on a pair of side walls that are arranged opposite each other along the direction parallel to the elongated hole. The support plate has a functional plate that is positioned toward the first limiting guide, and the second limiting guide is disposed on the functional plate.

9. A sampling device, characterized in that, include: Sampling assembly, sampling tube, and waste liquid collection assembly as described in any one of claims 1 to 8; The sampling assembly includes a sample collection container that is movably moved below the first hole to receive the sample dripping from the sampling tube.

10. A sampling reaction apparatus, characterized in that, Includes: a sampling assembly, a sampling tube, and a waste liquid collection assembly as described in any one of claims 1 to 8, as well as a reaction vessel having a reaction chamber; The sampling assembly includes: a sample collection container, a sampling tube connected to the reaction chamber, and the sample collection container being movable below the first hole to receive the sample dripping from the sampling tube.

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