Montmorillonite co-loaded silymarin nanosuspension and preparation method thereof
By leveraging the synergistic effects of montmorillonite, liquid phospholipids, and chitosan, silymarin nanosuspensions were prepared, solving the problems of loading and delivery of hydrophobic silymarin in animals. This resulted in highly efficient solubility, dissolution rate, and liver-targeted delivery, improving animal health and production performance while reducing preparation costs.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HUNAN DATANG BIOTECHNOLOGY CO LTD
- Filing Date
- 2026-03-11
- Publication Date
- 2026-05-26
AI Technical Summary
Existing technologies are difficult to effectively load hydrophobic silymarin, making it impossible to achieve efficient nano-dispersion and liver-targeted delivery in animals. Furthermore, the preparation process is complex and costly, making it unsuitable for animal feed additives.
Montmorillonite-co-loaded silymarin nanosuspensions were prepared using montmorillonite, liquid phospholipids, and chitosan. Silymarin was loaded onto the surface and interlayer of montmorillonite through liquid phospholipids, forming a nano-dispersion system with a particle size distribution of 150–320 nm. The preparation was carried out using high-speed shearing and high-pressure homogenization techniques.
It significantly improves the solubility, dissolution rate and oral bioavailability of silymarin, enables liver-targeted delivery, significantly improves animal liver health, enhances production performance, and reduces preparation costs, making it suitable for large-scale production.
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