Montmorillonite co-loaded silymarin nanosuspension and preparation method thereof

By leveraging the synergistic effects of montmorillonite, liquid phospholipids, and chitosan, silymarin nanosuspensions were prepared, solving the problems of loading and delivery of hydrophobic silymarin in animals. This resulted in highly efficient solubility, dissolution rate, and liver-targeted delivery, improving animal health and production performance while reducing preparation costs.

CN122074593APending Publication Date: 2026-05-26HUNAN DATANG BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-11
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing technologies are difficult to effectively load hydrophobic silymarin, making it impossible to achieve efficient nano-dispersion and liver-targeted delivery in animals. Furthermore, the preparation process is complex and costly, making it unsuitable for animal feed additives.

Method used

Montmorillonite-co-loaded silymarin nanosuspensions were prepared using montmorillonite, liquid phospholipids, and chitosan. Silymarin was loaded onto the surface and interlayer of montmorillonite through liquid phospholipids, forming a nano-dispersion system with a particle size distribution of 150–320 nm. The preparation was carried out using high-speed shearing and high-pressure homogenization techniques.

Benefits of technology

It significantly improves the solubility, dissolution rate and oral bioavailability of silymarin, enables liver-targeted delivery, significantly improves animal liver health, enhances production performance, and reduces preparation costs, making it suitable for large-scale production.

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Abstract

This invention belongs to the field of feed additives, and particularly relates to a montmorillonite-co-loaded silymarin nanosuspension and its preparation method. The montmorillonite-co-loaded silymarin nanosuspension comprises montmorillonite, silymarin, liquid phospholipids, and chitosan, wherein silymarin is loaded onto the surface and interlayer of montmorillonite via liquid phospholipids, forming a nano-dispersion system with a particle size distribution of 150–320 nm. The montmorillonite-co-loaded silymarin nanosuspension and its preparation method provided by this invention achieve efficient loading, nano-dispersion, and liver-targeted delivery of silymarin.
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Citation Information

Patent Citations

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  • Preparation method and application of spray curing nano-carrier powder for improving bioavailability of silymarin

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