Nanoparticles for loading dihydroberberine, their preparation method and applications
By constructing polydopamine and modified polyethylene glycol nanoparticles, dihydroberberine was loaded in ethanol using π–π stacking and hydrogen bonding, solving the problem of stable loading in aqueous systems and achieving efficient drug delivery and biocompatibility.
CN122075441APending Publication Date: 2026-05-26ZHUHAI PEOPLES HOSPITAL GUANGDONG PROVINCE
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- ZHUHAI PEOPLES HOSPITAL GUANGDONG PROVINCE
- Filing Date
- 2026-04-22
- Publication Date
- 2026-05-26
AI Technical Summary
Technical Problem
Existing technologies struggle to achieve stable loading and drug delivery of dihydroberberine in aqueous systems without complex chemical modifications, due to its extremely low water and organic solvent solubility.
Method used
Nanoparticles were constructed using polydopamine and modified polyethylene glycol, and dihydroberberine was loaded onto them through π–π stacking and hydrogen bonding. The drug was loaded in an ethanol solvent to ensure stable binding between the drug and the nanoparticles.
Benefits of technology
Uniform loading and stable dispersion of dihydroberberine were achieved. The nanoparticles have good biocompatibility and dispersibility, and the drug loading can reach 16.9%. Moreover, the preparation process is green and environmentally friendly.
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Figure CN122075441A_ABST
Abstract
This invention discloses nanoparticles for loading dihydroberberine, their preparation method, and applications. The nanoparticles comprise polydopamine (PDA) and polyethylene glycol modified with the PDA. The polyethylene glycol can be amino-NH2-terminated polyethylene glycol. In preparing the nanoparticles, dopamine hydrochloride is oxidatively self-polymerized under alkaline conditions to obtain PDA nanoparticles; the PDA nanoparticles are then modified with polyethylene glycol to obtain the nanoparticles. Utilizing the aromatic ring structure of the PDA in the nanoparticles, dihydroberberine can be stably loaded onto the nanoparticle surface through π–π stacking interactions and hydrogen bonding. These nanoparticles can effectively load and stably encapsulate dihydroberberine without complex chemical modifications to the dihydroberberine molecule, and are relatively safe and biocompatible.
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