Microneedle demolding device

Abstract

The utility model discloses a microneedle demoulding device which comprises a base, a clamp sliding block, a positioning base and a driving device, the positioning base and the clamp sliding block are both arranged on one side of the base. The positioning base comprises sliding connection faces located on the peripheral side, the positioning base comprises at least two sliding connection faces located on different side faces, the sliding connection faces and the vertical plane are arranged in an included angle mode, and the sliding connection faces are correspondingly connected with the clamp sliding blocks in a sliding and embedded mode. The bottom of the clamp sliding block abuts against the base, and the clamp sliding block can slide in a reciprocating mode in the inclined axial direction of the sliding connection face. The driving device is in transmission connection with the positioning base, and the driving device is used for driving the positioning base to reciprocate in the vertical direction. According to the technical scheme, the separating and demolding efficiency between the convex micro needle head structure and the mold is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of microneedle production equipment, in particular to a microneedle demoulding device. Background Art

[0002] The microneedle patch product is equipped with a microneedle array, and active ingredients such as drugs are arranged on the microneedle array. The microneedle array can penetrate into the skin, safely and painlessly forming a micron-level drug transmission channel in the skin, enhancing the skin's permeability to large molecular active ingredients and drugs, thereby effectively transporting drugs and other active ingredients in the microneedle array into the skin, safely and painlessly, and achieving transdermal drug delivery.

[0003] Traditional microneedles are narrow at the top and wide at the bottom. This type of structure has certain limitations in terms of drug delivery and cannot guarantee the effective penetration of the active ingredient content. At the same time, because the skin is elastic, when the patch is pressed and released, the skin will rebound and squeeze the inserted microneedles out of the skin, which is unstable and affects the full penetration and absorption of the drug. After this problem, people have made corresponding embedded microneedle patches. The needle tip of the microneedle has a barbed protrusion structure, which can increase the amount of drug delivery and ensure that the microneedle will not be squeezed out due to the skin's force rebound after entering the skin.

[0004] However, due to the inverted convex structure of the needle head of this type of microneedle, after being cast in the mold, the needle head and the mold are interlocked and cannot be directly separated from the mold, resulting in low demolding efficiency and difficulty in mass production. Therefore, a device is needed to improve the separation and demolding efficiency between the convex microneedle head structure and the mold. Utility Model Content

[0005] The main purpose of the utility model is to provide a microneedle demoulding device, aiming to improve the separation and demoulding efficiency between a convex microneedle head structure and a mold.

[0006] To achieve the above-mentioned purpose, the microneedle demoulding device proposed in the utility model includes a base, a fixture slider, a positioning base and a driving device; the positioning base and the fixture slider are both arranged on one side of the base;

[0007] The positioning base includes a sliding surface located on the peripheral side, and the positioning base includes at least two sliding surfaces located on different sides, the sliding surfaces are arranged at an angle with the vertical plane, and each sliding surface is correspondingly slidably engaged with the fixture slider;

[0008] The bottom of the clamp slider is in contact with the base, and the clamp slider can slide back and forth along the inclined axis of the sliding surface;

[0009] The driving device is in driving connection with the positioning base, and the driving device is used for driving the positioning base to reciprocate in a vertical direction.

[0010] In some embodiments of the present invention, the microneedle demoulding device further comprises an elastic reset member, wherein the elastic reset member is disposed between the fixture slider and the positioning base, and the elastic reset member can provide an elastic force to move the positioning base away from the base.

[0011] In some embodiments of the present utility model, the driving device includes a driving motor and a screw rod, the driving motor is fixed to the other side of the base, the output end of the driving motor is transmission-connected to one end of the screw rod, and the driving motor is used to drive the screw rod to rotate;

[0012] The base is provided with an opening, and the other end of the screw rod passes through the base from the opening and is threadedly connected with the positioning base.

[0013] In some embodiments of the present invention, the inclined angle between the sliding surface and the base is an acute angle. When the inclined angle between the sliding surface and the base is an acute angle, the inclined angle between the sliding surface and the base is 75-89.99°.

[0014] In some embodiments of the present invention, the inclined angle between the sliding surface and the base is an obtuse angle. When the inclined angle between the sliding surface and the base is an obtuse angle, the inclined angle between the sliding surface and the base is 90.01-105°.

[0015] In some embodiments of the utility model, the elastic return member is arranged between the sliding surface and the clamp slider, the axial direction of the elastic return member is the same as the inclined axial direction of the sliding surface, one end of the elastic return member abuts against the clamp slider, and the other end of the elastic return member abuts against the positioning base, and the elastic return member is a compression spring.

[0016] In some embodiments of the present invention, the clamp slider includes a clamping portion and a sliding portion, the sliding portion is fixed to the clamping portion, the sliding portion is slidably engaged with the sliding surface, and the clamping portion is used to clamp and fix the edge of the microneedle mold.

[0017] In some embodiments of the present invention, the clamping portion includes a clamping plate and a fastening bolt, the clamping plate is superimposed on the sliding portion, and the fastening bolt passes through the clamping plate and is threadedly connected to the sliding portion.

[0018] In some embodiments of the utility model, a limiting groove is provided on one side of the clamp slider facing the positioning base, and the height of the limiting groove is greater than the height of the positioning base; the positioning base is embedded in the limiting groove, and the sliding surface is slidably embedded with the clamp slider in the limiting groove.

[0019] In some embodiments of the present invention, the sliding surfaces are correspondingly arranged on the four sides of the positioning base, and each of the sliding surfaces is correspondingly connected to the fixture slider.

[0020] In some embodiments of the present invention, the sliding surface is provided with a convex groove along its inclined axial direction, and the clamp slider is provided with a groove position engaged with the convex groove.

[0021] The technical solution of the utility model realizes the fixation of the microneedle mold by clamping the microneedle mold with the clamp slider, and the vertically inclined sliding surface is slidably engaged with the clamp slider. When the positioning base moves in the vertical direction, the sliding surface slides relative to the clamp slider, and under the push of the inclined sliding surface, the relative separation or approach between the clamp sliders is realized, and the microneedle mold is fixed to drive the stretching and resetting of the microneedle mold. When the microneedle mold is stretched, the pinhole of the elastic microneedle mold is expanded by stretching, so that the protruding microneedle head structure is disengaged from the pinhole of the microneedle mold. The operator or equipment can directly separate the microneedle from the top to realize the demolding process between the microneedle and the microneedle mold, thereby avoiding the interference of the microneedle with the pinhole of the microneedle mold during separation, resulting in damage and breakage of the microneedle. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying creative work.

[0023] Figure 1 This is one of the structural schematic diagrams of the microneedle demoulding device of the utility model;

[0024] Figure 2 This is the second structural schematic diagram of the microneedle demoulding device of the utility model;

[0025] Figure 3 This is a cross-sectional view of the structure of the microneedle demoulding device of the utility model

[0026] Figure 4 This is a structural explosion diagram of the microneedle demoulding device of the utility model.

[0027] Description of Figure Numbers:

[0028] 100, base; 200, fixture slider; 210, clamping part; 211, clamping plate; 220, sliding part; 230, limiting groove; 300, positioning base; 310, sliding surface; 400, driving device; 410, driving motor; 420, screw rod; 500, elastic reset part; 600, microneedle mold;

[0029] The realization of the purpose, functional features and advantages of the utility model will be further explained in conjunction with embodiments and with reference to the accompanying drawings. DETAILED DESCRIPTION

[0030] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0031] It should be noted that all directional indications in the embodiments of the present invention (such as up, down, left, right, front, back...) are only used to explain the relative position relationship, movement status, etc. between the components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indication will also change accordingly.

[0032] In addition, the descriptions of "first", "second", etc. in the present utility model are only used for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In addition, the technical solutions between the various embodiments can be combined with each other, but they must be based on the ability of ordinary technicians in the field to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection required by the present utility model.

[0033] See attached Figure 1-4 The utility model provides a microneedle demoulding device, comprising a base 100, a clamp slider 200, a positioning base 300 and a driving device 400; the positioning base 300 and the clamp slider 200 are both arranged on one side of the base 100; the positioning base 300 and the clamp slider 200 are supported by the base 100, and the clamp slider 200 is used to clamp the microneedle mold 600. Preferably, the microneedle mold 600 is an elastic PDMS mold.

[0034] The positioning base 300 includes a sliding surface 310 located on the peripheral side, and the positioning base 300 includes at least two sliding surfaces 310 on different sides, and the sliding surface 310 is set at an angle with the vertical plane, and each sliding surface 310 is correspondingly slidably engaged with a clamp slider 200; the bottom of the clamp slider 200 abuts against the base 100, and the clamp slider 200 can slide back and forth along the inclined axis of the sliding surface 310; by moving the positioning base 300 in the vertical direction, the sliding engagement of the clamp slider 200 and the sliding surface 310 is achieved, and then the clamp sliders 200 are moved away from each other to stretch the microneedle mold 600.

[0035] The driving device 400 is in transmission connection with the positioning base 300 , and is used to drive the positioning base 300 to move back and forth in the vertical direction, thereby controlling the clamp sliders 200 to move away from or close to each other, thereby achieving the stretching and resetting of the microneedle mold 600 .

[0036] The microneedle mold 600 is clamped by the clamp slider 200 to achieve fixation of the microneedle mold 600. The vertically inclined sliding surface 310 is slidably engaged with the clamp slider 200. When the positioning base 300 moves in the vertical direction, the sliding surface 310 slides relative to the clamp slider 200. Under the push of the inclined sliding surface 310, the relative distance or approach between the clamp sliders 200 is achieved. The microneedle mold 600 is fixed and then stretched and reset. When the microneedle mold 600 is stretched, the pinhole of the elastic microneedle mold 600 is expanded by stretching, so that the protruding microneedle head structure is disengaged from the pinhole of the microneedle mold 600. The operator or equipment can directly separate the microneedle from the top to achieve the demolding process between the microneedle and the microneedle mold 600, thereby avoiding the interference of the microneedle with the pinhole of the microneedle mold 600 during separation, resulting in damage and breakage of the microneedle.

[0037] Among them, the driving device 400 includes a driving motor 410 and a screw rod 420. The driving motor 410 is fixed to the other side of the base 100. The output end of the driving motor 410 is transmission-connected to one end of the screw rod 420. The driving motor 410 is used to drive the screw rod 420 to rotate. The base 100 is provided with an opening. The other end of the screw rod 420 passes through the base 100 from the opening and is threadedly connected to the positioning base 300. The screw rod 420 is driven to rotate by the driving motor 410. Through the threaded cooperation between the screw rod 420 and the positioning base 300, when the screw rod 420 rotates, the positioning base 300 can move vertically along the axial direction of the screw rod 420.

[0038] Furthermore, the inclined angle between the sliding surface 310 and the base 100 is an acute angle. More preferably, the inclined angle between the sliding surface 310 and the base 100 is 75-89.99°. Because the microneedles are generally 20-2000 microns in size and require high precision, the precision requirements of the microneedle mold 600 are also corresponding. When the inclined angle between the sliding surface 310 and the base 100 is closer to 89.99°, the more accurate the deformation precision control of the microneedle mold 600 is, the less damage the mold will be, and the better the durability will be. When the positioning base 300 moves from the bottom relative to the clamp slider 200, the clamp slider 200 slides relative to the sliding surface 310. At this time, the clamp slider 200 also moves relatively away from the positioning base 300 to achieve a stretching effect on the microneedle mold 600, and the microneedle mold 600 is deformed. When the positioning base 300 moves from the top relative to the clamp slider 200, because the microneedle mold 600 is fixed on the clamp slider 200, the microneedle mold 600 recovers its deformation, thereby achieving the stretching and resetting operation of the clamp slider 200 on the microneedle mold 600.

[0039] Furthermore, the inclined angle between the sliding surface 310 and the base 100 is an obtuse angle. More preferably, the inclined angle between the sliding surface 310 and the base 100 is 90.01-105°. Because the microneedles are generally 20-2000 microns in size and require high precision, the precision requirements of the microneedle mold 600 are also corresponding. When the inclined angle between the sliding surface 310 and the base 100 is closer to 90.01°, the more accurate the deformation precision control of the microneedle mold 600 is, the less damage the mold will be, and the better the durability will be. When the positioning base 300 moves from the top relative to the clamp slider 200, the clamp slider 200 slides relative to the sliding surface 310. At this time, the clamp slider 200 also moves relatively away from the positioning base 300 to achieve a stretching effect on the microneedle mold 600, and the microneedle mold 600 is deformed. When the positioning base 300 moves from the bottom relative to the clamp slider 200, because the microneedle mold 600 is fixed on the clamp slider 200, the microneedle mold 600 recovers its deformation, thereby achieving the stretching and resetting operation of the clamp slider 200 on the microneedle mold 600.

[0040] In this embodiment, the microneedle demolding device may further include an elastic reset member 500, which is disposed between the fixture slider 200 and the positioning base 300. The elastic reset member 500 can provide an elastic force to move the positioning base 300 away from the base 100, so that the positioning base 300 can realize the stretching of the microneedle mold 600 by moving, and at the same time, the microneedle mold 600 can be reset after the microneedle is demolded by the reset elastic force.

[0041] Specifically, the elastic reset member 500 is arranged between the sliding surface 310 and the clamp slider 200, and the axial direction of the elastic reset member 500 is the same as the inclined axial direction of the sliding surface 310. One end of the elastic reset member 500 abuts against the clamp slider 200, and the other end of the elastic reset member 500 abuts against the positioning base 300. The elastic reset member 500 is a compression spring; the compression spring is used to make the positioning base 300 have an elastic force away from the base 100. When the driving device 400 drives the positioning base 300 to move toward the base 100, the compression spring is compressed to realize the descent of the positioning base 300, providing a reverse support force for the positioning base 300, and preventing the positioning base 300 from moving too fast and affecting the stretching stability of the microneedle mold 600; at the same time, under the inclined sliding engagement of the sliding surface 310, the clamp slider 200 stretches the microneedle mold 600. When the microneedle is demolded, the driving device 400 drives the reset while realizing the auxiliary reset elastic force on the positioning base 300 under the action of the compression spring.

[0042] Specifically, the clamp slider 200 includes a clamping portion 210 and a sliding portion 220. The sliding portion 220 is fixed to the clamping portion 210. The sliding portion 220 is slidably engaged with the sliding surface 310. The clamping portion 210 is used to clamp and fix the edge of the microneedle mold 600. The sliding of the sliding portion 220 relative to the positioning base 300 can drive the clamping portion 210 to move away from the positioning base 300. The clamping portion 210 clamps the edge of the microneedle mold 600 to achieve stretching of the microneedle mold 600, thereby achieving separation and demolding of the microneedle and the microneedle mold 600.

[0043] In this embodiment, the clamping part 210 includes a clamping plate 211 and a fastening bolt. The clamping plate 211 is overlapped on the sliding part 220. The fastening bolt is passed through the clamping plate 211 and is threadedly connected to the sliding part 220. By adjusting the fastening bolt, the distance between the clamping plate 211 and the sliding part 220 can be adjusted to achieve the tightness adjustment of the clamping of the microneedle mold 600.

[0044] Furthermore, a limiting groove 230 is provided on the side of the clamp slider 200 facing the positioning base 300, and the height of the limiting groove 230 is greater than the height of the positioning base 300; the positioning base 300 is embedded in the limiting groove 230, and the sliding surface 310 is slidably embedded with the clamp slider 200 in the limiting groove 230; the limiting grooves 230 of multiple clamp sliders 200 are enclosed to form a movable space for accommodating the positioning base 300, so that the positioning base 300 can move vertically in the limiting groove 230 of the clamp slider 200, realizing the movement limitation of the positioning base 300, avoiding the positioning base 300 from excessively rising or falling, causing the clamp slider 200 to excessively stretch or squeeze the mold and damage the mold, thereby improving the safety and stability of the stretching operation of the microneedle mold 600.

[0045] Among them, sliding surfaces 310 are correspondingly arranged on the four sides of the positioning base 300, and each sliding surface 310 is correspondingly connected to a clamp slider 200. Through the four relatively arranged sliding surfaces 310 and the correspondingly connected clamp sliders 200, the microneedle demoulding device can clamp the four sides of the microneedle mold 600, stretch the four sides of the microneedle mold 600, and further improve the separation stability of the microneedle and the mold.

[0046] In this embodiment, the sliding surface 310 is provided with a convex groove along its inclined axis, and the clamp slider 200 is provided with a groove position that is engaged with the convex groove. Through the sliding engagement between the convex groove and the groove position, the sliding guide between the positioning base 300 and the clamp slider 200 is realized, thereby improving the vertical movement of the positioning base 300 and the sliding stability of the clamp slider 200 on the sliding surface 310; preferably, a plurality of ball bearings can also be provided in the convex groove, so that the ball bearings can achieve rolling abutment between the convex groove and the groove position during sliding engagement, and the rolling of the ball bearings can reduce the relative sliding friction between the convex groove and the groove position, thereby reducing the friction loss between the convex groove and the groove position, thereby improving the practical life of the microneedle demolding device.

[0047] The working process of the microneedle demoulding device is as follows: when the device is in the reset completion state, the microneedle mold 600 is placed on the clamping part 210, and then fixed by tightening the bolts. After fixing, the motor 410 is driven to rotate, driving the screw rod 420 to move the positioning base 300 vertically downward. Because the positioning base 300 is narrow at the bottom and wide at the top, the sliding part 220 slidably engaged with the positioning base 300 will perform multi-axial movement. When the sliding part 220 is active, it will drive the clamping part 210 to perform multi-axial movement to stretch the silicone microneedle mold 600. According to the real-time torque feedback of the driving motor 410, when the preset value is reached, the driving motor 410 stops rotating and maintains the torque. At this time, the silicone microneedle mold 600 has been stretched, the micropores are enlarged, and the microneedles with the protruding needle structure can be separated normally. At this time, the microneedles can be easily separated and demoulded out completely using a vacuum suction cup or manually. After the separation is completed, the driving motor 410 rotates counterclockwise back to its original position, the locking bolts are loosened, and the microneedle mold 600 is taken out.

[0048] The above description is only a preferred embodiment of the present invention, and does not limit the patent scope of the present invention. All equivalent structural changes made by using the contents of the present invention specification and drawings under the inventive concept of the present invention, or directly / indirectly applied in other related technical fields are included in the patent protection scope of the present invention.

Claims

1. A microneedle demoulding device, characterized in that: It includes a base, a fixture slider, a positioning base and a driving device; the positioning base and the fixture slider are both arranged on one side of the base; The positioning base includes a sliding surface located on the peripheral side, and the positioning base includes at least two sliding surfaces located on different sides, the sliding surfaces are arranged at an angle with the vertical plane, and each sliding surface is correspondingly slidably engaged with the fixture slider; The bottom of the clamp slider is in contact with the base, and the clamp slider can slide back and forth along the inclined axis of the sliding surface; The driving device is in driving connection with the positioning base, and the driving device is used for driving the positioning base to reciprocate in a vertical direction.

2. The microneedle demoulding device according to claim 1, characterized in that: The microneedle demoulding device further comprises an elastic reset member for providing an elastic force to move the positioning base away from the base, and the elastic reset member is arranged between the fixture slider and the positioning base.

3. The microneedle demoulding device according to claim 2, characterized in that: The elastic reset member is arranged between the sliding surface and the clamp slider, the axial direction of the elastic reset member is the same as the inclined axial direction of the sliding surface, one end of the elastic reset member abuts against the clamp slider, and the other end of the elastic reset member abuts against the positioning base, and the elastic reset member is a compression spring.

4. The microneedle demoulding device according to claim 1, characterized in that: The driving device comprises a driving motor and a screw rod, wherein the driving motor is fixed to the other side of the base, the output end of the driving motor is drivingly connected to one end of the screw rod, and the driving motor is used to drive the screw rod to rotate; The base is provided with an opening, and the other end of the screw rod passes through the base from the opening and is threadedly connected with the positioning base.

5. The microneedle demoulding device according to any one of claims 1 to 4, characterized in that: The inclined angle between the sliding surface and the base is an acute angle or an obtuse angle.

6. The microneedle demoulding device according to claim 5, characterized in that: When the inclined angle between the sliding surface and the base is an acute angle, the inclined angle between the sliding surface and the base is 75-89.99°; when the inclined angle between the sliding surface and the base is an obtuse angle, the inclined angle between the sliding surface and the base is 90.01-105°.

7. The microneedle demoulding device according to claim 1, characterized in that: The clamp slider comprises a clamping portion and a sliding portion, wherein the sliding portion is fixed to the clamping portion, the sliding portion is slidably engaged with the sliding surface, and the clamping portion is used to clamp and fix the edge of the microneedle mold.

8. The microneedle demoulding device according to claim 1, characterized in that: A limiting groove is provided on one side of the clamp slider facing the positioning base, and the height of the limiting groove is greater than the height of the positioning base; the positioning base is embedded in the limiting groove, and the sliding surface is slidably embedded with the clamp slider in the limiting groove.

9. The microneedle demoulding device according to claim 1, characterized in that: The sliding surfaces are correspondingly arranged on the four sides of the positioning base, and each of the sliding surfaces is correspondingly connected to the fixture slider.

10. The microneedle demoulding device according to claim 1, characterized in that: The sliding surface is provided with a convex groove along its inclined axial direction, and the clamp slider is provided with a groove position which is engaged and connected with the convex groove.

Images