Sample analyzer

Abstract

The present application relates to a sample analyzer, comprising: a reaction device having an outer disc mechanism for bearing and conveying a reaction container after sample adding; a reagent storage device; the filling device is provided with a loading station, a filling station and a transferring station, the filling device comprises a conveying mechanism and a liquid transferring mechanism, the conveying mechanism is provided with a plurality of conveying frames, and all the conveying frames are controlled to synchronously rotate and circularly pass through the loading station, the filling station and the transferring station; the pipetting mechanism is used for transferring the reagent in the reagent storage device into the reaction container on the conveying frame of the filling station; the transferring device comprises a filling grabbing mechanism, and the filling grabbing mechanism is used for transferring the reaction containers on the outer disc mechanism to the conveying frame of the loading station and transferring the reaction containers on the conveying frame of the transferring station to the outer disc mechanism. The sample analyzer provided by the utility model has relatively high detection speed.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and in particular to a sample analyzer. Background Art

[0002] Taking the immunoassay analyzer in the sample analyzer as an example, the immunoassay analyzer is a highly sensitive and specific analytical instrument that has developed rapidly worldwide in recent years. It is used in clinical laboratories to detect various immune indicators of samples such as blood, urine or other body fluids. The principle is to combine the two technologies of antibody-antigen reaction and chemiluminescence to achieve high specificity and high sensitivity.

[0003] In an immunoassay analyzer, reagents need to be added to the reaction container after sample addition so that the sample can react with the reagents and generate the test substance. In the immunoassay analyzer in the related art, for test items with large reagent addition amount and / or need to add multi-component reagents, the reagent addition time is long, resulting in a decrease in the detection speed of the immunoassay analyzer. Utility Model Content

[0004] Based on this, it is necessary to provide a sample analyzer that can improve the detection speed in order to solve the above problems.

[0005] A sample analyzer, comprising:

[0006] A reaction device having an outer plate mechanism, wherein the outer plate mechanism is used to carry and transport the reaction container after the sample is added;

[0007] Reagent storage device;

[0008] A filling device, having a loading station, a filling station and a transfer station, the filling device including a conveying mechanism and a liquid transfer mechanism, the conveying mechanism having a plurality of conveying racks, all of which are controlled to rotate synchronously and circulate through the loading station, the filling station and the transfer station, the liquid transfer mechanism being used to transfer the reagent in the reagent storage device to the reaction container on the conveying rack of the filling station; and

[0009] The transfer device includes a filling and grabbing mechanism, which is used to transfer the reaction container on the outer disk mechanism to the conveying rack of the loading station, and is used to transfer the reaction container on the conveying rack of the transfer station to the outer disk mechanism.

[0010] In some embodiments, the number of each of the filling station, the liquid transfer mechanism, and the reagent storage device is at least two, and each of the filling station and the reagent storage device corresponds to the liquid transfer mechanism one by one;

[0011] Each of the liquid transfer mechanisms is used to transfer the reagent in the corresponding reagent storage device to the reaction container of the corresponding filling station.

[0012] In some embodiments, the pipetting mechanism includes a pipetting base, a first pipetting needle group and a second pipetting needle group, wherein the first pipetting needle group and the second pipetting needle group are disposed on the pipetting base;

[0013] The reagent storage device stores a plurality of reagents. The first pipetting needle group and the second pipetting needle group are both used to transfer at least one reagent in the reagent storage device to the same reaction container. The reagents transferred to the same reaction container by the first pipetting needle group and the second pipetting needle group are different.

[0014] In some embodiments, the first pipetting needle assembly includes a first pipetting arm and a first pipetting needle transmission-connected to the first pipetting arm, the first pipetting arm is used to drive the first pipetting needle to move along a first direction and a third direction, and to drive the first pipetting needle to rotate in a rotation plane formed by the intersection of the first direction and the second direction;

[0015] The second pipetting needle group includes a second pipetting arm and a second pipetting needle transmission-connected to the second pipetting arm, wherein the second pipetting arm is used to drive the second pipetting needle to move along the first direction and the third direction, and to drive the second pipetting needle to rotate within the rotation plane;

[0016] Wherein, the first direction and the second direction both intersect with the third direction.

[0017] In some embodiments, the filling device also includes a first cleaning mechanism and a second cleaning mechanism, and the first cleaning mechanism and the second cleaning mechanism are arranged on the reagent storage device. The first cleaning mechanism is used to clean the first pipetting needle after each pipetting by the first pipetting needle is completed, and the second cleaning mechanism is used to clean the second pipetting needle after each pipetting by the second pipetting needle is completed.

[0018] In some embodiments, the conveying mechanism includes a conveying base, a conveying motor, a first transmission wheel, a second transmission wheel, a transmission synchronous belt, a conveying driving wheel, a conveying driven wheel and a conveying synchronous belt, wherein the conveying motor, the first transmission wheel, the second transmission wheel and the transmission synchronous belt are located on the bottom side of the conveying base, and the conveying driving wheel, the conveying driven wheel and the conveying synchronous belt are all located on the top side of the base;

[0019] The conveying motor is connected to the first transmission wheel, the transmission synchronous belt is sleeved outside the first transmission wheel and the second transmission wheel, the second transmission wheel and the conveying driving wheel are coaxially connected, the conveying synchronous belt is sleeved outside the conveying driving wheel and the conveying driven wheel, and all the conveying frames are fixed to the conveying synchronous belt.

[0020] In some embodiments, the conveying mechanism further includes a spreading member, which is located between the conveying driving wheel and the conveying driven wheel and is sleeved in the conveying synchronous belt, and the spreading member is used to spread the conveying synchronous belt.

[0021] In some embodiments, the reagent storage device has a plurality of storage cavities arranged along a first direction, and each of the storage cavities extends along a second direction intersecting the first direction;

[0022] The reagent storage device also has multiple groups of reagent hole groups, all of which are arranged in sequence along the first direction and correspond one-to-one to all of the storage cavities; all of the reagent holes in each group of the reagent hole groups are arranged along the second direction, and each of the reagent holes in the same group of the reagent hole groups is connected to the storage cavity corresponding to the reagent hole group.

[0023] In some embodiments, the outer disk mechanism includes an outer disk and an outer disk driving unit, the outer disk is drivingly connected to the outer disk driving unit, and the outer disk is used to carry and transport the reaction container after sample addition.

[0024] In some embodiments, the reaction device further comprises an inner plate mechanism, wherein the inner plate mechanism comprises a constant temperature seat, a first plate assembly and a second plate assembly;

[0025] The first disk assembly includes a first disk and a first driving unit, the first disk is arranged on the constant temperature seat and is transmission-connected to the first driving unit, the second disk assembly includes a second disk and a second driving unit, the second disk is arranged on the constant temperature seat and is arranged around the outer circumference of the first disk, and the second disk is transmission-connected to the second driving unit, the outer disk is arranged around the outer circumference of the second disk, the first disk and the second disk are both used to carry the mixed reaction container, and the constant temperature seat is used to provide a constant temperature reaction environment for the reaction container.

[0026] The above-mentioned sample analyzer is provided with a loading station, a filling station and a transfer station by setting a filling device, and a conveying mechanism has multiple conveying racks, all of which are controlled to rotate synchronously and circulate through the loading station, the filling station and the transfer station. In the process from when the filling grasping mechanism places the reaction container after sample addition at the loading station to when the filling grasping mechanism puts the reaction container at the transfer station back to the outer disk mechanism, the filling device can fill the reaction container at the filling station outside the reaction device. When filling the reagent, the pipetting mechanism only needs to go back and forth between the reagent storage device and the filling station of the filling device arranged outside the reaction device and transfer the reagent to complete the reagent filling work. Not only the movement stroke of the pipetting mechanism is shortened, but also the filling grasping mechanism can transfer the reaction container after the reagent is added to the outer disk mechanism. Because the action of the filling grabbing mechanism is simpler than the reagent filling action and has a fixed duration, using the filling grabbing mechanism to interact with the reaction device can greatly save the impact of the reagent filling time on the sample analyzer, so it is beneficial to speed up the sample analyzer and increase the test throughput, thereby improving the detection speed of the sample analyzer. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 This is a schematic diagram of the structure of a sample analyzer in some embodiments of the present application.

[0028] Figure 2 for Figure 1 A top view of the cooperation among the reagent storage device, the reaction device and the transport mechanism in the sample analysis is shown.

[0029] Figure 3 for Figure 1 Schematic diagram of the structure of the reaction device in the sample analyzer shown.

[0030] Figure 4 for Figure 1 The schematic diagram of the structure of the reagent storage device in the sample analyzer cooperating with the first cleaning mechanism and the second cleaning mechanism is shown.

[0031] Figure 5 for Figure 1 A top view of the transport mechanism in the sample analyzer is shown.

[0032] Figure 6 for Figure 5 A bottom view of the conveying mechanism is shown.

[0033] Figure 7 for Figure 1 Schematic diagram of the structure of the pipetting mechanism in the sample analyzer shown.

[0034] Figure 8 for Figure 7 Bottom view of the pipetting mechanism shown.

[0035] Fig. 9for Figure 1 The schematic diagram of the structure of the filling and grabbing mechanism in the sample analyzer is shown.

[0036] Fig.10 for Fig. 9 Bottom view of the fill grip mechanism shown.

[0037] Figure Number:

[0038] 1. Sample analyzer; 2. Reaction container;

[0039] 10. reaction device; 20. reagent storage device; 30. filling device; 40. transfer device;

[0040] 11. outer disk mechanism; 111. outer disk; 112. outer disk drive unit; 12. inner disk mechanism; 121. constant temperature seat; 122. first disk assembly; 1221. first disk; 1222. first drive unit; 123. second disk assembly; 1231. second disk; 1232. second drive unit; 13. placement hole;

[0041] 21. storage cavity; 22. reagent well group; 221. reagent well;

[0042] 31. Conveying mechanism; 311. Conveying rack; 3111. First conveying rack; 3112. Second conveying rack; 3113. Third conveying rack; 3114. Fourth conveying rack; 312. Conveying base; 313. Conveying motor; 314. First transmission wheel; 315. Second transmission wheel; 316. Transmission timing belt; 317. Conveying driving wheel; 318. Conveying driven wheel; 319. Conveying timing belt; 320. Spreading member; 32. Liquid transfer mechanism; 321. Liquid transfer base; 322. First liquid transfer needle group; 3221. First liquid transfer arm; 3221a. First liquid transfer motor; 3221b. First liquid transfer driving wheel; 3221c. First liquid transfer driven wheel Wheel; 3221d, the first pipetting timing belt; 3221e, the second pipetting seat; 3221f, the second pipetting motor; 3221g, the second pipetting driving wheel; 3221h, the second pipetting driven wheel; 3221j, the second pipetting timing belt; 3221k, the third pipetting seat; 3221n, the third pipetting driving wheel; 3221r, the third pipetting driven wheel; 3221s, the third pipetting timing belt; 3222, the first pipetting needle; 323, the second pipetting needle group; 3231, the second pipetting arm; 3232, the second pipetting needle; 33, the first cleaning mechanism; 34, the second cleaning mechanism; 35, the loading station; 36, the filling station; 37, the transfer station.

[0043] 41. Filling and grabbing mechanism; 411. First grabbing assembly; 4111. First grabbing base; 4112. First grabbing motor; 4113. First grabbing driving wheel; 4114. First grabbing driven wheel; 4115. First grabbing synchronous belt; 412. Second grabbing assembly; 4121. Second grabbing base; 4122. Second grabbing motor; 4123. Second grabbing driving wheel; 4124. Second grabbing driven wheel; 4125. Second grabbing synchronous belt; 413. Third grabbing assembly; 4131. Third grabbing base; 4132. Third grabbing motor; 4133. Gripper seat; 4134. Gripper;

[0044] L, dividing line; X, first direction; Y, second direction, Z, third direction. DETAILED DESCRIPTION

[0045] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present application, so the present application is not limited by the specific embodiments disclosed below.

[0046] In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "periphery" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0047] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of this application, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0048] In this application, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0049] In the present application, unless otherwise clearly specified and limited, a first feature being “above” or “below” a second feature may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, a first feature being “above”, “above”, and “above” a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being “below”, “below”, and “below” a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0050] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used herein are for illustrative purposes only and are not intended to be the only implementation method.

[0051] See also Figure 1 The present application provides a sample analyzer 1, which is used to detect samples and provide a basis for clinical treatment. The sample analyzer 1 can be an immunoassay analyzer, a coagulation analyzer, a blood cell analyzer, a urine analyzer, etc., and the specific type is not limited here. For the convenience of explanation, the following embodiments are all described by taking the sample analyzer 1 as an immunoassay analyzer as an example.

[0052] The sample analyzer 1 includes a storage device, a transfer device 40, a filling device 30, a mixing device, a reaction device 10, a cleaning device and a measuring device. The storage device includes a sample storage device and a reagent storage device 20. The sample storage device is used to store samples required for detection, and the reagent storage device 20 is used to store reagents that react with samples. The transfer device 40 is used to drive the reaction container 2 to transfer between the filling device 30, the reaction device 10, the cleaning device and the measuring device. The filling device 30 is used to transfer the sample in the sample storage device and the reagent in the reagent storage device 20 to the reaction container 2 in sequence, the mixing device is used to mix the sample and the reagent, and the reaction device 10 is used to carry and transport the reaction container 2, and can incubate the mixed sample and reagent so that the sample can fully combine and react with the reagent to ensure the accuracy of the sample detection. The cleaning device is used to clean and remove impurities in the reaction container 2 after incubation, so that the object to be detected is left in the reaction container 2. The measuring device is used to detect the object to be detected to obtain the detection parameters of the sample to meet the detection requirements.

[0053] For ease of understanding, the names of the sample and reagent at each stage are described in detail here: the sample and reagent in the reaction container 2 are mixed and called a mixture, and the reaction device 10 can incubate the mixture in the reaction container 2 so that the sample and reagent react fully. After the reaction, the substances in the reaction container 2 are the analyte and impurities.

[0054] That is to say, the mixture after the reaction is presented in the form of the substance to be detected and impurities. Impurities can be substances that have not reacted fully, side reaction products produced by side reactions, or other substances that affect the detection of the measuring device, etc.

[0055] The reaction container 2 may be a reaction cup, a reaction tube, etc. The specific form of the reaction container 2 may be selected as required.

[0056] Please also read Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 7 and Fig. 9 In some embodiments of the present application, the reaction device 10 has an outer disk mechanism 11 and an inner disk mechanism 12. The outer disk mechanism 11 is used to carry and transport the reaction container 2 after the sample is added, and the inner disk mechanism 12 is used to incubate the mixture after the sample and the reagent are mixed.

[0057] The filling device 30 has a sample adding station, a loading station 35, a filling station 36 and a transfer station 37. The filling device 30 includes a sample adding mechanism, a conveying mechanism 31 and a pipetting mechanism 32. The sample adding mechanism is used to transfer the sample in the sample storage device to the reaction container 2 located at the sample adding station. The conveying mechanism 31 has multiple conveying racks 311. All conveying racks 311 are controlled to rotate synchronously and circulate through the loading station 35, the filling station 36 and the transfer station 37. The pipetting mechanism 32 is used to transfer the reagent in the reagent storage device 20 to the reaction container 2 on the conveying rack 311 of the filling station 36.

[0058] The transfer device 40 includes a sample adding grabbing mechanism, a filling grabbing mechanism 41 and an incubation grabbing mechanism. The sample adding grabbing mechanism is used to place the empty reaction container 2 on the sample adding station for sample adding, and transfer the reaction container 2 to the outer disk mechanism 11 after the sample adding is completed. The filling grabbing mechanism 41 is used to transfer the reaction container 2 on the outer disk mechanism 11 to the conveying rack 311 of the loading station 35, and is used to transfer the reaction container 2 on the conveying rack 311 of the transfer station 37 to the outer disk mechanism 11. The incubation grabbing mechanism is used to transfer the mixed reaction container 2 on the outer disk 111 to the inner disk mechanism 12 for incubation.

[0059] Among them, all the conveyor racks 311 are arranged in sequence along the rotation direction of any conveyor rack 311. At the same time, the loading station 35, the filling station 36 and the transfer station 37 all have conveyor racks 311, and all the conveyor racks 311 rotate synchronously in the clockwise direction (such as Figure 5 After one rotation (in the direction indicated by the middle arrow W), each conveying rack 311 passes through the loading station 35, the filling station 36 and the transfer station 37.

[0060] The number of the conveyor racks 311 may be the same as the sum of the number of the loading stations 35, the filling stations 36 and the transfer stations 37, or may be a multiple of the number of the loading stations 35, the filling stations 36 and the transfer stations 37. For example, if the number of the conveyor racks 311 is the same as the sum of the number of the loading stations 35, the filling stations 36 and the transfer stations 37 and is three, then all the conveyor racks 311 synchronously rotate three grids in the clockwise direction for one circle.

[0061] It is defined that the conveyor rack 311 on the loading station 35 is the first conveyor rack, the conveyor rack 311 on the filling station 36 is the second conveyor rack, and the conveyor rack 311 on the transfer station 37 is the third conveyor rack. All the conveyor racks 311 rotate synchronously by one grid, the first conveyor rack moves to the filling station 36, the second conveyor rack moves to the transfer station 37, and the third conveyor rack moves to the loading station 35. Then, all the conveyor racks 311 rotate synchronously by one grid again, the first conveyor rack moves to the transfer station 37, the second conveyor rack moves to the loading station 35, and the third conveyor rack moves to the filling station 36. Then, all the conveyor racks 311 rotate synchronously by one grid again, so that all the conveyor racks 311 rotate for one circle, the first conveyor rack returns to the loading station 35, the second conveyor rack returns to the sample adding station, and the third conveyor rack returns to the loading station 35.

[0062] For another example, if the number of conveyor racks 311 is twice the total number of loading stations 35, filling stations 36 and transfer stations 37, and the total number of loading stations 35, filling stations 36 and transfer stations 37 is three, then all conveyor racks 311 rotate synchronously in a clockwise direction for six grids per circle.

[0063] It is defined that the conveyor rack 311 on the loading station 35 at the beginning is the first conveyor rack, the conveyor rack 311 between the loading station 35 and the filling station 36 is the second conveyor rack, the conveyor rack 311 on the filling station 36 is the third conveyor rack, the conveyor rack 311 between the filling station 36 and the transfer station 37 is the fourth conveyor rack, the conveyor rack 311 on the transfer station 37 is the fifth conveyor rack, and the conveyor rack between the transfer station 37 and the loading station 35 is the sixth conveyor rack. All the conveyor racks 311 rotate synchronously by one grid, the first conveyor rack moves to between the loading station 35 and the filling station 36, the second conveyor rack moves to the filling station 36, the third conveyor rack moves to between the filling station 36 and the transfer station 37, the fourth conveyor rack moves to the transfer station 37, the fifth conveyor rack moves to between the transfer station 37 and the loading station 35, the sixth conveyor rack moves to the loading station 35, and so on. Finally, all the conveyor racks 311 rotate one grid synchronously, so that when all the conveyor racks 311 rotate one circle in total, the first conveyor rack returns to the loading station 35, the second conveyor rack returns to between the loading station 35 and the filling station 36, the third conveyor rack returns to the filling station 36, the fourth conveyor rack returns to between the filling station 36 and the transfer station 37, the fifth conveyor rack returns to the transfer station 37, and the sixth conveyor rack returns to between the transfer station 37 and the loading station 35.

[0064] For the convenience of explanation, the following embodiments are described by taking the example that the number of the conveying racks 311 is the same as the sum of the number of the loading stations 35 , the filling stations 36 and the transfer stations 37 .

[0065] In actual operation, the outer disk mechanism 11 transfers the reaction container 2 after adding the sample on the outer disk mechanism 11 to the working area of ​​the filling and grabbing mechanism 41, and the filling and grabbing mechanism 41 grabs the reaction container 2 after adding the sample and places it on the idle conveyor rack 311 located at the loading station 35. Afterwards, the filling and grabbing mechanism 41 grabs the reaction container 2 after adding the reagent on the conveyor rack 311 located at the transfer station 37 and puts it back to the outer disk mechanism 11. The outer disk mechanism 11 drives the reaction container 2 after adding the reagent to pass through the working areas of the mixing device and the incubation and grabbing mechanism in sequence. The mixing device mixes the sample and reagent in the reaction container 2, and then the incubation and grabbing mechanism grabs the mixed reaction container 2 and places it on the inner disk mechanism 12 for incubation, so that the sample and the reagent can fully react to ensure the accuracy of the sample detection.

[0066] During the period from when the filling grasping mechanism 41 grasps the reaction container 2 after sample addition and places it on the conveying rack 311 of the loading station 35 to when the filling grasping mechanism 41 grasps the reaction container 2 after reagent addition and places it back on the outer disk mechanism 11, the liquid transfer mechanism 32 transfers the reagent in the reagent storage device 20 to the reaction container 2 of the conveying rack 311 located at the filling station 36 to perform the reagent addition operation on the reaction container 2. Afterwards, all conveying racks 311 rotate synchronously, so that the conveying rack 311 located at the filling station 36 drives the reaction container 2 thereon to move to the transfer station 37 for transfer, and the conveying rack 311 located at the loading station 35 drives the reaction container 2 thereon to move to the filling station 36 for reagent addition, and the idle conveying rack 311 located at the transfer station 37 moves to the loading station 35 to receive the next reaction container 2 after sample addition.

[0067] In the related art, the filling device 30 directly fills the reagent into the reaction container 2 located on the outer disk mechanism 11 through the pipetting mechanism 32. However, for the test items with a large reagent filling amount and / or the need to fill multi-component reagents, the action of filling the reagent usually takes a long time. When the reagent is filled on the outer disk mechanism 11, the outer disk mechanism 11 cannot rotate, and must wait for the reagent filling to be completed before rotating to the next process. The long reagent filling time leads to the problem of long waiting time of the outer disk mechanism 11, which is ultimately not conducive to speeding up the sample analyzer 1 and increasing the test throughput, and the detection speed of the sample analyzer 1 is also reduced.

[0068] It can be understood that the test throughput refers to the number of reaction containers 2 that can be tested per unit time.

[0069] In the present application, the filling device 30 is provided with a loading station 35, a filling station 36 and a transfer station 37, and the conveying mechanism 31 is provided with a plurality of conveying racks 311, and all conveying racks 311 are controlled to rotate synchronously and circulate through the loading station 35, the filling station 36 and the transfer station 37. In the process that the filling grasping mechanism 41 places the reaction container 2 after the sample is added at the loading station 35, and the filling grasping mechanism 41 puts the reaction container 2 at the transfer station 37 back to the outer disk mechanism 11, the filling device 30 can fill the reaction container 2 located at the filling station 36 outside the reaction device 10. When the reagent is filled, the liquid transfer mechanism 32 only needs to go back and forth between the reagent storage device 20 and the filling station 36 of the filling device 30 arranged outside the reaction device 10 and transfer the reagent to complete the reagent filling work. Not only the movement stroke of the liquid transfer mechanism 32 is shortened, but also the filling grasping mechanism 41 can transfer the reaction container 2 after the reagent is added to the outer disk mechanism 11. That is to say, the interaction between the filling device 30 and the outer disk mechanism 11 in the prior art is converted into the interaction between the filling grabbing mechanism 41 and the outer disk mechanism 11. Since the filling grabbing mechanism 41 has a simple action and a fixed duration, the interaction between the filling grabbing mechanism 41 and the outer disk mechanism 11 can greatly save the impact of the reagent filling time on the outer disk mechanism 11, which is beneficial to speeding up the sample analyzer 1 and increasing the test throughput, thereby improving the detection speed of the sample analyzer 1.

[0070] In addition, compared with the related art in which the pipetting mechanism 32 in the filling device 30 directly transfers the reagent in the reagent storage device 20 to the reaction container 2 on the outer disk mechanism 11, this design also makes the operation of reagent filling in the sample analyzer 1 relatively independent from the incubation, cleaning, measurement and other operations in the sample analyzer 1. Therefore, the optimization of the filling device 30 will not affect the overall design of the sample analyzer 1, which helps to reduce the design difficulty of the sample analyzer 1 and improve the reliability and stability of the sample analyzer 1.

[0071] Please refer again Figure 3The outer disk mechanism 11 includes an outer disk 111 and an outer disk drive unit 112, and the outer disk 111 is in driving connection with the outer disk drive unit 112. The outer disk 111 is used to carry and transfer the reaction container 2 after the sample is added. The outer disk 111 is provided with a placement hole 13 for placing the reaction container 2. The outer disk drive unit 112 drives the outer disk 111 to rotate, so that all the placement holes 13 arranged along the circumference of the outer disk 111 can enter the working area of ​​the filling and grasping mechanism 41 in sequence, so as to facilitate the filling and grasping mechanism 41 to transfer the reaction container 2 in the placement hole 13 in its working area to the loading station 35, and transfer the reaction container 2 in the transfer station 37 to the placement hole 13 in its working area. During the process of transferring the reaction container 2 by the filling and grabbing mechanism 41, some of the placement holes 13 arranged along the circumference of the outer disk 111 are respectively located in the working areas of the mixing device and the incubation grabbing mechanism. The mixing mechanism mixes the reaction container 2 in the placement holes 13 located in its own working area, and the incubation grabbing mechanism grabs the reaction container 2 located in its own working area and places it on the inner disk mechanism 12 for incubation.

[0072] The inner disk mechanism 12 includes a thermostatic seat 121, a first disk assembly 122, and a second disk assembly 123. The first disk assembly 122 includes a first disk 1221 and a first drive unit 1222, the first disk 1221 is disposed on the thermostatic seat 121 and is in transmission connection with the first drive unit 1222, the second disk assembly 123 includes a second disk 1231 and a second drive unit 1232, the second disk 1231 is disposed on the thermostatic seat 121 and is disposed around the outer circumference of the first disk 1221, and the second disk 1231 is in transmission connection with the second drive unit 1232, and the outer disk 111 is disposed around the outer circumference of the second disk 1231. Both the first disk 1221 and the second disk 1231 are used to carry the mixed reaction container 2, and the thermostatic seat 121 is used to provide a constant temperature reaction environment for the reaction container 2.

[0073] Among them, the first plate 1221, the second plate 1231 and the outer plate 111 are coaxially arranged, and the first plate 1221 and the second plate 1231 are also provided with placement holes 13 for placing the reaction vessel 2. The first driving unit 1222 drives the first plate 1221 to rotate, and the second driving unit 1232 drives the second plate 1231 to rotate, so that the placement holes 13 arranged along the respective circumferences of the first plate 1221 and the second plate 1231 can be located in the working area of ​​the incubation grasping mechanism, and the incubation grasping mechanism selectively places the grasped reaction vessel 2 in the placement hole 13 of the first plate 1221 or the second plate 1231 located in its own working area to fix the reaction vessel 2.

[0074] As an example, the outer disk drive unit 112, the first drive unit 1222 and the second drive unit 1232 can all be a combination of a drive motor, a drive driving wheel, a drive driven wheel and a drive synchronous belt. The drive motor is connected to the drive driving wheel, and the drive synchronous belt is sleeved on the drive driving wheel and the drive driven wheel. In some embodiments, at least one of the outer disk 111, the first disk 1221 and the second disk 1231 is formed by a drive driven wheel structure. In some embodiments, at least one of the outer disk 111, the first disk 1221 and the second disk 1231 is fixedly connected to the drive driven wheel so as to be able to rotate.

[0075] Of course, the forms of the external disk drive unit 112, the first drive unit 1222 and the second drive unit 1232 are not limited to the above two forms, and may also be other forms, which are not specifically limited here.

[0076] The thermostatic seat 121 includes a seat body, a heating element and thermal insulation cotton. A thermostatic bath is provided in the seat body. The heating element is located at the bottom of the seat body. The thermal insulation cotton wraps the seat body and the heating element. The heating element is used for heating, and the thermal insulation cotton is used to isolate the heat exchange between the outside and the seat body and the heating element, so as to form a constant temperature reaction environment in the thermostatic bath.

[0077] The first plate 1221 and the second plate 1231 are jointly covered at the notch of the thermostatic bath, and the placement holes 13 on the first plate 1221 and the second plate 1231 are both extended into the thermostatic bath. When the reaction container 2 is inserted into the placement hole 13 on the first plate 1221 or the second plate 1231, a section of the reaction container 2 containing the mixture extends into the thermostatic bath, so that the mixture in the reaction container 2 can be located in the thermostatic bath and incubated in the constant temperature reaction environment provided by the entire thermostatic seat 121.

[0078] By setting the first plate 1221 and the second plate 1231, and the first plate 1221 and the second plate 1231 are independently driven and operated by their respective corresponding driving units, multiple reaction containers 2 can be separately set on the first plate 1221 and the second plate 1231, and the load of the first plate 1221 and the second plate 1231 is reduced and it is convenient to speed up, which is beneficial to improving the working efficiency of the reaction device 10, and then the detection speed of the sample analyzer 1 is improved.

[0079] In addition, since the second disk 1231 is arranged around the outer side of the first disk 1221, and the outer disk 111 is arranged around the outer side of the second disk 1231, the transfer path of the reaction container 2 between the outer disk 111 and the first disk 1221, and between the outer disk 111 and the second disk 1231 is shortened, the transfer of the reaction container 2 is more efficient, and the working efficiency of the reaction device 10 is higher, thereby further improving the detection speed of the sample analyzer 1.

[0080] Please refer again Figure 2 and Figure 4The reagent storage device 20 has a plurality of storage cavities 21 arranged along a first direction X, each storage cavity 21 extending along a second direction Y intersecting the first direction X, and the reagent storage device 20 also has a plurality of reagent well groups 22, all reagent well groups 22 are arranged in sequence along the first direction X, and correspond one-to-one to all storage cavities 21. All reagent wells 221 in each reagent well group 22 are arranged along the second direction Y, and each reagent well 221 in the same reagent well group 22 is connected to the storage cavity 21 corresponding to the reagent well group 22.

[0081] Each storage cavity 21 is also provided with a plurality of reagent storage components for storing reagents. In the same storage cavity 21, all reagent storage components are arranged in sequence along the second direction Y, and all reagent storage components in the same storage cavity 21 correspond to all reagent holes 221 connected to the storage cavity 21. In actual operation, the liquid transfer mechanism 32 extends into the corresponding reagent storage component through the reagent hole 221 to absorb the reagent. The reagent storage component can be box-shaped, tubular, etc., which is not specifically limited here.

[0082] According to the detection requirements, different reagent storage components in the same storage cavity 21 can be used to store the same or different reagents, and reagent storage components in different storage cavities 21 can also be used to store the same or different reagents, which can be specifically set according to the detection items.

[0083] For the convenience of explanation, the following embodiments are described by taking different reagent storage components in the same storage cavity 21 as an example for storing different reagents, and the reagent storage methods in different storage cavities 21 are completely the same. The reagent storage methods in different storage cavities 21 are completely the same means that: in the second direction Y, the arrangement method of the reagent storage parts storing different reagents in different storage cavities 21 is the same.

[0084] For example, Figure 2 For example, each storage cavity 21 has seven reagent storage components, and the seven reagent storage components in the same storage cavity 21 are used to store different reagents. In the second direction Y and in the direction from the outer disk mechanism 11 to the conveying mechanism 31, the reagent storage components in each storage cavity 21 are arranged in the following manner: a reagent storage component for storing a first reagent, a reagent storage component for storing a second reagent, a reagent storage component for storing a third reagent, a reagent storage component for storing a fourth reagent, a reagent storage component for storing a fifth reagent, a reagent storage component for storing a sixth reagent, and a reagent storage component for storing a seventh reagent.

[0085] Please also read Figure 5 and Figure 6The conveying mechanism 31 includes a conveying base 312, a conveying motor 313, a first transmission wheel 314, a second transmission wheel 315, a transmission synchronous belt 316, a conveying driving wheel 317, a conveying driven wheel 318 and a conveying synchronous belt 319. The conveying motor 313, the first transmission wheel 314, the second transmission wheel 315 and the transmission synchronous belt 316 are located on the bottom side of the conveying base 312, and the conveying driving wheel 317, the conveying driven wheel 318 and the conveying synchronous belt 319 are all located on the top side of the base; the conveying motor 313 is connected to the first transmission wheel 314 in transmission connection, the transmission synchronous belt 316 is sleeved outside the first transmission wheel 314 and the second transmission wheel 315, the second transmission wheel 315 and the conveying driving wheel 317 are coaxially connected, the conveying synchronous belt 319 is sleeved outside the conveying driving wheel 317 and the conveying driven wheel 318, and all the conveying frames 311 are fixed to the conveying synchronous belt 319.

[0086] During actual operation, the conveying motor 313 transmits power to the conveying synchronous belt 319 via the first transmission wheel 314, the transmission synchronous belt 316, the second transmission wheel 315 and the conveying driving wheel 317 in sequence to drive all the conveying racks 311 to rotate synchronously, so that all the conveying racks 311 can stably flow on the loading station 35, the filling station 36 and the transfer station 37.

[0087] Furthermore, in some embodiments of the present application, the conveying mechanism 31 also includes a spreading member 320 , which is located between the conveying driving wheel 317 and the conveying driven wheel 318 , and is sleeved in the conveying timing belt 319 . The spreading member 320 is used to spread the conveying timing belt 319 .

[0088] The conveying synchronous belt 319 and the expansion member 320 both extend along the second direction Y, and the expansion member 320 can be in a block shape, a strip shape or other shapes.

[0089] The arrangement of the expansion member 320 can expand and tension the conveying synchronous belt 319 to facilitate the conveying synchronous belt 319 to transport the conveying rack 311 .

[0090] Please refer again Figure 1 and Figure 2 , and also see Figure 5 , Figure 7 and Figure 8 In some embodiments of the present application, there are at least two filling stations 36, pipetting mechanisms 32 and reagent storage devices 20, and the filling stations 36 and the reagent storage devices 20 correspond one-to-one to the pipetting mechanisms 32; each pipetting mechanism 32 is used to transfer the reagent in the corresponding reagent storage device 20 to the reaction container 2 of the corresponding filling station 36.

[0091] For convenience of explanation, the following example is taken as an example that there are two filling stations 36 and the number of conveying racks 311 is the same as the sum of the number of loading stations 35, filling stations 36 and transfer stations 37, which is four. Correspondingly, there are two reagent storage devices 20 and two liquid transfer mechanisms 32.

[0092] like Figure 2 As shown, the conveying base 312 extends along the second direction Y, and its center line extending along the second direction Y forms a dividing line L. The position of the conveying base 312 located above the right side of the dividing line L forms a loading station 35, the position of the conveying base 312 located below the right side of the dividing line L forms a first filling station 36, the position of the conveying base 312 located below the left side of the dividing line L forms a second filling station 36, and the position of the conveying base 312 located above the left side of the dividing line L forms a transfer station 37. One of the reagent storage devices 20 and one of the liquid transfer mechanisms 32 are both located on the right side of the dividing line L, and the other reagent storage device 20 and the other liquid transfer mechanism 32 are both located on the left side of the dividing line L. The liquid transfer mechanism 32 on the right side is used to transfer the reagent in the reagent storage device 20 on the right side to the reaction container 2 of the filling station 36 on the right side, and the liquid transfer mechanism 32 on the left side is used to transfer the reagent in the reagent storage device 20 on the left side to the reaction container 2 of the filling station 36 on the left side.

[0093] Combination Figure 2 and Figure 5 , Figure 2 The diagram shows that initially, the first conveyor rack 3111 is located at the loading station 35, the second conveyor rack 3112 is located at the filling station 36 on the right, the third conveyor rack 3113 is located at the filling station 36 on the left, and the fourth conveyor rack 3114 is located at the transfer station 37. At this time, no reaction container 2 is set on the first conveyor rack 3111, the second conveyor rack 3112, the third conveyor rack 3113 and the fourth conveyor rack 3114.

[0094] After the sample analyzer 1 starts working, when the first reaction container 2 placed on the outer disk 111 rotates into the working area of ​​the filling and grabbing mechanism 41, the outer disk 111 stops rotating. The filling and grabbing mechanism 41 grabs the first reaction container 2 and places it on the first conveyor rack 3111. Then, all the conveyor racks 311 rotate one grid in the clockwise direction, so that the first conveyor rack 3111 drives the first reaction container 2 to move to the filling station 36 on the right, the second conveyor rack 3112 moves to the filling station 36 on the left, the third conveyor rack 3113 moves to the transfer station 37, and the fourth conveyor rack 3114 moves to the loading station 35. At the same time, the outer disk 111 rotates, so that the second reaction container 2 placed on the outer disk 111 is also located in the working area of ​​the filling and grabbing mechanism 41, and the outer disk 111 stops rotating. The filling and grabbing mechanism 41 places the second reaction container 2 on the fourth conveyor rack 311 located at the loading station 35. Then, all the conveyor racks 311 rotate one grid clockwise again, so that the first conveyor rack 3111 drives the first reaction container 2 to move to the filling station 36 on the left, the second conveyor rack 3112 moves to the transfer station 37, the third conveyor rack 3113 moves to the loading station 35, and the fourth conveyor rack 3114 drives the second reaction container 2 to move to the filling station 36 on the right.

[0095] Afterwards, the right pipetting mechanism 32 transfers the reagent in the right reagent storage device 20 to the reaction container 2 at the right filling station 36, and at the same time, the left pipetting mechanism 32 transfers the reagent in the left reagent storage device 20 to the reaction container 2 at the left filling station 36. During this process, the filling gripping mechanism 41 places the third reaction container 2 on the third conveying rack 3113 located at the loading station 35.

[0096] It is worth mentioning that in some other embodiments, the right-side pipetting mechanism 32 and the left-side pipetting mechanism 32 may also stagger the filling of reagents into the corresponding reaction container 2. This is to avoid interference between the right-side pipetting mechanism 32 and the left-side pipetting mechanism 32 during the filling of reagents. For the convenience of description, the following embodiments are all described by taking the right-side pipetting mechanism 32 and the left-side pipetting mechanism 32 as an example of simultaneously filling reagents into the corresponding reaction container 2.

[0097] Then, all the conveyor racks 311 rotate one more grid, so that the first conveyor rack 3111 drives the first reaction container 2 to move to the transfer station 37, the second conveyor rack 3112 moves to the loading station 35, the third conveyor rack 3113 drives the third reaction container 2 to move to the filling station 36 on the right, and the fourth conveyor rack 3114 drives the second reaction container 2 to move to the filling station 36 on the left. At this time, the filling grabbing mechanism 41 places the fourth reaction container 2 on the outer disk 111 on the second conveyor rack 3112 at the loading station 35, and then transfers the reaction container 2 on the first conveyor rack 3111 at the transfer station 37 to the outer disk 111.

[0098] Then, all the conveyor racks 311 rotate one more grid, so that when all the conveyor racks 311 rotate one circle in total, the first conveyor rack 3111 returns to the loading station 35, the second conveyor rack 3112 drives the fourth reaction container 2 to move to the filling station 36 on the right, the third conveyor rack 3113 drives the third reaction container 2 to move to the filling station 36 on the left, and the fourth conveyor rack 3114 drives the second reaction container 2 to move to the transfer station 37.

[0099] After that, every time all the conveying racks 311 rotate one grid, the right-side pipetting mechanism 32 and the left-side pipetting mechanism 32 synchronously add reagents to the reaction containers 2 at the respective filling stations 36. At the same time, the filling and grabbing mechanism 41 alternately places the reaction containers 2 with added samples in its working area on the conveying rack 311 at the loading station 35, and places the reaction containers 2 with added reagents at the transfer station 37 on the outer disk 111. Moreover, during the entire working process of the sample analyzer 1, the filling and grabbing mechanism 41 and the pipetting mechanism 32 continuously and repeatedly perform this step.

[0100] Under such working conditions, the filling device 30 can add reagents to the two reaction containers 2 simultaneously or at different times, and the sample adding efficiency of the sample adding device is improved, so the rotation speed of the outer disk 111 can also be increased accordingly. This filling device 30 and filling process can avoid the prolonged transfer time of the reaction container 2 in the reaction device 10 due to the long reagent filling action, thereby improving the test throughput of the sample analyzer 1. In addition, the time taken by the filling grabbing mechanism 41 to transfer the reaction container 2 is relatively short, which further improves the test throughput.

[0101] In some embodiments of the present application, the pipetting mechanism 32 includes a pipetting base 321, a first pipetting needle group 322 and a second pipetting needle group 323, and the first pipetting needle group 322 and the second pipetting needle group 323 are arranged on the pipetting base 321; a plurality of reagents are stored in the reagent storage device 20, and the first pipetting needle group 322 and the second pipetting needle group 323 are both used to transfer at least one reagent in the reagent storage device 20 to the same reaction container 2, and the reagents transferred to the same reaction container 2 by the first pipetting needle group 322 and the second pipetting needle group 323 are different.

[0102] Below, Figure 2 The specific working process of the first pipetting needle group 322 and the second pipetting needle group 323 in the state of the sample analyzer 1 is described in detail. In this embodiment, there are two pipetting mechanisms 32, reagent storage devices 20 and filling stations 36. Different reagent storage components in the same storage cavity 21 are used to store different reagents, and the reagent storage methods in different storage cavities 21 are exactly the same. Since the working principle of the pipetting mechanism 32 on the right side of the dividing line L is the same as the working principle of the pipetting mechanism 32 on the left side of the dividing line L, in order to avoid redundancy, only the working process of the first pipetting needle group 322 and the second pipetting needle group 323 of the pipetting mechanism 32 on the right side of the dividing line L is described. On the right side of the dividing line L, defined in the second direction Y and in the direction from the outer disk mechanism 11 to the conveying mechanism 31, the seven reagent wells 221 in each reagent well group 22 are respectively the first reagent well 221, the second reagent well 221...the seventh reagent well 221. Assuming that the first pipetting needle group 322 is used to absorb the reagent in the reagent storage part corresponding to the first four reagent holes 221 in each reagent hole group 22, and the second pipetting needle group 323 is used to absorb the reagent in the reagent storage part corresponding to the last three reagent holes 221 in each reagent hole group 22, in actual operation, the first pipetting needle group 322 absorbs the reagent in the reagent storage part corresponding to the first four reagent holes 221 in any reagent hole group 22 in the right reagent storage device 20, and then injects it into the reaction container 2 of the right filling station 36, and the second pipetting needle group 323 absorbs the reagent in the reagent storage part corresponding to the last three reagent holes 221 in the above-mentioned reagent hole group 22, and then injects it into the reaction container 2 of the right filling station 36.

[0103] It is worth mentioning that in Figure 2In FIG. 4 , the area defined by the box A represents the working area of ​​the filling and grabbing mechanism 41. The area defined by the circle B in the upper left corner on the right side of the dividing line L represents the working area when the first pipetting needle group 322 of the right pipetting mechanism 32 is closest to the dividing line L in the first direction X. The area defined by the circle C in the upper right corner on the right side of the dividing line L represents the working area when the first pipetting needle group 322 of the right pipetting mechanism 32 is farthest from the dividing line L in the first direction X. During the movement of the first pipetting needle group 322 in the first direction X, its working area covers all areas between the area defined by the circle B and the area defined by the circle C.

[0104] The area defined by the circle D at the lower left corner on the right side of the dividing line L represents the working area when the second pipetting needle group 323 of the right pipetting mechanism 32 is closest to the dividing line L in the first direction X. The area defined by the circle E at the lower right corner on the right side of the dividing line L represents the working area when the second pipetting needle group 323 of the right pipetting mechanism 32 is farthest from the dividing line L in the first direction X. During the movement of the second pipetting needle group 323 in the first direction X, its working area covers all areas between the area defined by the circle D and the area defined by the circle E.

[0105] The area defined by the circle F at the upper right corner on the left side of the dividing line L represents the working area when the first pipetting needle group 322 of the left pipetting mechanism 32 is closest to the dividing line L in the first direction X. The area defined by the circle G at the upper left corner on the left side of the dividing line L represents the working area when the first pipetting needle group 322 of the left pipetting mechanism 32 is farthest from the dividing line L in the first direction X. During the movement of the first pipetting needle group 322 in the first direction X, its working area covers all areas between the area defined by the circle F and the area defined by the circle G.

[0106] The area defined by the circle H at the lower right corner on the left side of the dividing line L represents the working area when the second pipetting needle group 323 of the left pipetting mechanism 32 is closest to the dividing line L in the first direction X. The area defined by the circle K at the lower left corner on the left side of the dividing line L represents the working area when the second pipetting needle group 323 of the left pipetting mechanism 32 is farthest from the dividing line L in the first direction X. During the movement of the second pipetting needle group 323 in the first direction X, its working area covers all areas between the area defined by the circle H and the area defined by the circle K.

[0107] In this embodiment, for detection items that require the addition of multiple reagents, by setting the first pipetting needle group 322 and the second pipetting needle group 323 in the same pipetting mechanism 32, the first pipetting needle group 322 and the second pipetting needle group 323 can simultaneously absorb different reagents and successively add them into the same reaction container 2, making the reagent addition more efficient.

[0108] Please refer again Figure 7 and Figure 8 In some embodiments of the present application, the first pipetting needle group 322 includes a first pipetting arm 3221 and a first pipetting needle 3222 transmission-connected to the first pipetting arm 3221, and the first pipetting arm 3221 is used to drive the first pipetting needle 3222 to move along the first direction X and the third direction Z, and drive the first pipetting needle 3222 to rotate in a rotation plane formed by the intersection of the first direction X and the second direction Y;

[0109] The second pipetting needle group 323 includes a second pipetting arm 3231 and a second pipetting needle 3232 transmission-connected to the second pipetting arm 3231, and the second pipetting arm 3231 is used to drive the second pipetting needle 3232 to move along the first direction X and the third direction Z, and drive the second pipetting needle 3232 to rotate within the rotation plane; wherein the first direction X and the second direction Y both intersect with the third direction Z.

[0110] Specifically, the first pipetting arm 3221 includes a first pipetting unit, a second pipetting unit and a third pipetting unit.

[0111] The first liquid transfer unit includes a first liquid transfer motor 3221a, a first liquid transfer driving wheel 3221b, a first liquid transfer driven wheel 3221c and a first liquid transfer synchronous belt 3221d. The first liquid transfer motor 3221a is arranged on the side of the liquid transfer base 321 facing away from the conveying mechanism 31, and is in transmission connection with the first liquid transfer driving wheel 3221b. The first liquid transfer driving wheel 3221b, the first liquid transfer driven wheel 3221c, the first liquid transfer synchronous belt 3221d, the second liquid transfer unit, the third liquid transfer unit and the first liquid transfer needle 3222 are all located on the side of the liquid transfer base 321 facing the conveying unit. The first liquid transfer synchronous belt 3221d is sleeved on the first liquid transfer driving wheel 3221b and the first liquid transfer driven wheel 3221c.

[0112] The second liquid transfer unit includes a second liquid transfer seat 3221e, a second liquid transfer motor 3221f, a second liquid transfer driving wheel 3221g, a second liquid transfer driven wheel 3221h and a second liquid transfer synchronous belt 3221j. The second liquid transfer motor 3221f is arranged on the second liquid transfer seat 3221e and is in transmission connection with the second liquid transfer driving wheel 3221g, and the second liquid transfer synchronous belt 3221j is sleeved outside the second liquid transfer driving wheel 3221g and the second liquid transfer driven wheel 3221h.

[0113] The third pipetting unit includes a third pipetting seat 3221k, a third pipetting motor, a third pipetting driving wheel 3221n, a third pipetting driven wheel 3221r and a third pipetting synchronous belt 3221s. The third pipetting seat 3221k is fixedly connected to the second pipetting driven wheel 3221h. The third pipetting motor is arranged on the third pipetting seat 3221k and is in transmission connection with the third pipetting driving wheel 3221n. The third pipetting synchronous belt 3221s is sleeved on the third pipetting driving wheel 3221n and the third pipetting driven wheel 3221r. The first pipetting needle 3222 is fixed on the third pipetting synchronous belt 3221s.

[0114] The first pipetting motor 3221a is working to drive the first pipetting needle 3222 to move along the first direction X. The second pipetting motor 3221f is working to drive the first pipetting needle 3222 to rotate in a plane formed by the intersection of the first direction X and the second direction Y, so as to achieve the change of the position of the second pipetting needle 3232 in the second direction Y. The third pipetting motor is working to drive the first pipetting needle 3222 to move in the third direction Z.

[0115] The first pipetting arm 3221 and the second pipetting arm 3231 have the same structure, and the first pipetting needle 3222 and the second pipetting needle 3232 have the same structure, so the specific structures of the second pipetting arm 3231 and the second pipetting needle 3232 are not described in detail here.

[0116] See also Figure 2 and Figure 4 In some embodiments of the present application, the filling device 30 also includes a first cleaning mechanism 33 and a second cleaning mechanism 34. The first cleaning mechanism 33 and the second cleaning mechanism 34 are arranged on the reagent storage device 20. The first cleaning mechanism 33 is used to clean the first pipetting needle 3222 after each pipetting by the first pipetting needle 3222. The second cleaning mechanism 34 is used to clean the second pipetting needle 3232 after each pipetting by the second pipetting needle 3232.

[0117] The first cleaning mechanism 33 and the second cleaning mechanism 34 can be cleaning nozzles, cleaning cups, nozzles or other cleaning mechanisms, which can be specifically configured as required. The first cleaning mechanism 33 and the second cleaning mechanism 34 are conventional in the art, so they will not be described in detail here.

[0118] After the first pipetting needle 3222 and the second pipetting needle 3232 in the right pipetting mechanism 32 have successively filled the same reaction container 2 with reagents, the first pipetting needle 3222 moves to the first cleaning mechanism 33 for cleaning under the action of the first pipetting arm 3221, and the second pipetting needle 3232 moves to the second cleaning mechanism 34 for cleaning under the action of the second pipetting arm 3231. Afterwards, the first pipetting needle 3222 and the second pipetting needle 3232 move to the reagent storage device 20 to absorb the reagents under the action of the corresponding pipetting arms, respectively, to prepare for the next reagent filling.

[0119] by Figure 4 For example, there are two first cleaning mechanisms 33 and two second cleaning mechanisms 34, one of the first cleaning mechanisms 33 and one of the second cleaning mechanisms 34 are both arranged on the reagent storage device 20 on the right side, and the first cleaning mechanism 33 on the right side is used to clean the first pipetting needle 3222 of the right pipetting mechanism 32, and the second cleaning mechanism 34 on the right side is used to clean the second pipetting needle 3232 of the right pipetting mechanism 32, and the other first cleaning mechanism 33 and the other second cleaning mechanism 34 are both arranged on the reagent storage device 20 on the left side, and the first cleaning mechanism 33 on the left side is used to clean the first pipetting needle 3222 of the left pipetting mechanism 32, and the second cleaning mechanism 34 on the left side is used to clean the second pipetting needle 3232 of the left pipetting mechanism 32.

[0120] The first cleaning mechanism 33 and the second cleaning mechanism 34 can clean the first pipetting needle 3222 and the second pipetting needle 3232 to prevent the reagent carried by the first pipetting needle 3222 and the second pipetting needle 3232 from interfering with the next filling.

[0121] Please refer again Figure 1 , and also see Fig. 9 and Fig.10 The filling grabbing mechanism 41 includes a first grabbing component 411 , a second grabbing component 412 , a third grabbing component 413 and a grabber 4134 .

[0122] The first grabbing assembly 411 includes a first grabbing base 4111, a first grabbing motor 4112, a first grabbing driving wheel 4113, a first grabbing driven wheel 4114 and a first grabbing synchronous belt 4115. The first grabbing motor 4112 is installed on the side of the first grabbing base 4111 facing away from the conveying mechanism 31, and is in transmission connection with the first grabbing driving wheel 4113. The first grabbing driving wheel 4113, the first grabbing driven wheel 4114 and the first grabbing synchronous belt 4115 are located on the side of the first grabbing base 4111 facing the conveying mechanism 31. The first grabbing synchronous belt 4115 is sleeved on the first grabbing driving wheel 4113 and the first grabbing driven wheel 4114.

[0123] The second grabbing assembly 412 includes a second grabbing base 4121, a second grabbing motor 4122, a second grabbing driving wheel 4123, a second grabbing driven wheel 4124 and a second grabbing synchronous belt 4125. The second grabbing base 4121 is fixed to the first grabbing synchronous belt 4115, and the second grabbing motor 4122 is disposed on the second grabbing base 4121 and is in transmission connection with the second grabbing driving wheel 4123. The second grabbing synchronous belt 4125 is sleeved outside the second grabbing driving wheel 4123 and the second grabbing driven wheel 4124.

[0124] The third grabbing assembly 413 includes a third grabbing base 4131, a third grabbing motor 4132, a gripper seat 4133 and a gripper 4134. The third grabbing base 4131 is disposed on the second grabbing synchronous belt 4125, the third grabbing motor 4132 is fixed on the third grabbing base 4131, and the rotating shaft of the third grabbing motor 4132 is fixedly connected to the gripper seat 4133, and the gripper 4134 is disposed on the gripper seat 4133.

[0125] When the first grabbing motor 4112 is working, it can drive the grabber 4134 to move along the first direction X. When the second grabbing motor 4122 is working, it can drive the grabber 4134 to move along the second direction Y. When the third grabbing motor 4132 is working, it can drive the grabber 4134 to move along the third direction Z.

[0126] The sample analyzer 1 is provided with a loading station 35, a filling station 36 and a transfer station 37 by setting the filling device 30, and the conveying mechanism 31 has a plurality of conveying racks 311, and all the conveying racks 311 are controlled to rotate synchronously and circulate through the loading station 35, the filling station 36 and the transfer station 37. When the filling grabbing mechanism 41 places the reaction container 2 after the sample is added at the loading station 35, and when the filling grabbing mechanism 41 puts the reaction container 2 at the transfer station 37 back to the outer disk mechanism 11, the filling device 30 can fill the reaction container 2 located at the filling station 36 outside the reaction device 10. When the reagent is filled, the pipetting mechanism 32 only needs to go back and forth between the reagent storage device 20 and the filling station 36 of the filling device 30 arranged outside the reaction device 10 and transfer the reagent to complete the reagent filling work. Not only the movement stroke of the pipetting mechanism 32 is shortened, but also the filling grabbing mechanism 41 can transfer the reaction container 2 after the reagent is added to the outer disk mechanism 11. That is to say, the interaction between the filling device 30 and the outer disk mechanism 11 in the prior art is converted into the interaction between the filling grabbing mechanism 41 and the outer disk mechanism 11. Since the filling grabbing mechanism 41 has a simple action and a fixed duration, the interaction between the filling grabbing mechanism 41 and the outer disk mechanism 11 can greatly save the influence of the reagent filling time on the outer disk mechanism 11, so it is beneficial to speed up the sample analyzer 1 and increase the test throughput, thereby improving the detection speed of the sample analyzer 1.

[0127] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0128] The above-described embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be construed as limiting the scope of the patent application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent application shall be subject to the attached claims.

Claims

1. A sample analyzer, characterized in that: The sample analyzer comprises: A reaction device (10) having an outer disk mechanism (11), wherein the outer disk mechanism (11) is used to carry and transport the reaction container (2) after the sample is added; Reagent storage device (20); A filling device (30) having a loading station (35), a filling station (36) and a transfer station (37), the filling device (30) comprising a conveying mechanism (31) and a liquid transfer mechanism (32), the conveying mechanism (31) having a plurality of conveying racks (311), all of which are controlled to rotate synchronously and circulate through the loading station (35), the filling station (36) and the transfer station (37), the liquid transfer mechanism (32) being used to transfer the reagent in the reagent storage device (20) to the reaction container (2) on the conveying rack (311) of the filling station (36); and The transfer device (40) comprises a filling and grabbing mechanism (41), wherein the filling and grabbing mechanism (41) is used to transfer the reaction container (2) on the outer disk mechanism (11) to the conveying rack (311) of the loading station (35), and is used to transfer the reaction container (2) on the conveying rack (311) of the transfer station (37) to the outer disk mechanism (11).

2. The sample analyzer according to claim 1, characterized in that: The number of each of the filling station (36), the liquid transfer mechanism (32) and the reagent storage device (20) is at least two, and each of the filling station (36) and the reagent storage device (20) corresponds one-to-one to the liquid transfer mechanism (32); Each of the liquid transfer mechanisms (32) is used to transfer the reagent in the corresponding reagent storage device (20) to the reaction container (2) of the corresponding filling station (36).

3. The sample analyzer according to claim 1, characterized in that: The pipetting mechanism (32) comprises a pipetting base (321), a first pipetting needle group (322) and a second pipetting needle group (323), wherein the first pipetting needle group (322) and the second pipetting needle group (323) are arranged on the pipetting base (321); The reagent storage device (20) stores a plurality of reagents. The first pipetting needle group (322) and the second pipetting needle group (323) are both used to transfer at least one reagent in the reagent storage device (20) to the same reaction container (2). The reagents transferred to the same reaction container (2) by the first pipetting needle group (322) and the second pipetting needle group (323) are different.

4. The sample analyzer according to claim 3, characterized in that: The first pipetting needle group (322) comprises a first pipetting arm (3221) and a first pipetting needle (3222) transmission-connected to the first pipetting arm (3221), wherein the first pipetting arm (3221) is used to drive the first pipetting needle (3222) to move along a first direction (X) and a third direction (Z), and to drive the first pipetting needle (3222) to rotate within a rotation plane formed by the intersection of the first direction (X) and the second direction (Y); The second pipetting needle group (323) comprises a second pipetting arm (3231) and a second pipetting needle (3232) transmission-connected to the second pipetting arm (3231), wherein the second pipetting arm (3231) is used to drive the second pipetting needle (3232) to move along the first direction (X) and the third direction (Z), and to drive the second pipetting needle (3232) to rotate within the rotation plane; Wherein, the first direction (X) and the second direction (Y) both intersect with the third direction (Z).

5. The sample analyzer according to claim 4, characterized in that: The filling device (30) further comprises a first cleaning mechanism (33) and a second cleaning mechanism (34), wherein the first cleaning mechanism (33) and the second cleaning mechanism (34) are arranged on the reagent storage device (20), wherein the first cleaning mechanism (33) is used for cleaning the first pipetting needle (3222) after each pipetting by the first pipetting needle (3222), and the second cleaning mechanism (34) is used for cleaning the second pipetting needle (3232) after each pipetting by the second pipetting needle (3232).

6. The sample analyzer according to claim 1, characterized in that: The conveying mechanism (31) comprises a conveying base (312), a conveying motor (313), a first transmission wheel (314), a second transmission wheel (315), a transmission synchronous belt (316), a conveying driving wheel (317), a conveying driven wheel (318) and a conveying synchronous belt (319), wherein the conveying motor (313), the first transmission wheel (314), the second transmission wheel (315) and the transmission synchronous belt (316) are located on the bottom side of the conveying base (312), and the conveying driving wheel (317), the conveying driven wheel (318) and the conveying synchronous belt (319) are all located on the top side of the base; The conveying motor (313) is connected to the first transmission wheel (314) in a transmission manner, the transmission synchronous belt (316) is sleeved outside the first transmission wheel (314) and the second transmission wheel (315), the second transmission wheel (315) and the conveying driving wheel (317) are coaxially connected, the conveying synchronous belt (319) is sleeved outside the conveying driving wheel (317) and the conveying driven wheel (318), and the entire conveying frame (311) is fixed to the conveying synchronous belt (319).

7. The sample analyzer according to claim 6, characterized in that: The conveying mechanism (31) further comprises an opening member (320), wherein the opening member (320) is located between the conveying driving wheel (317) and the conveying driven wheel (318), and is sleeved inside the conveying synchronous belt (319), and the opening member (320) is used to open the conveying synchronous belt (319).

8. The sample analyzer according to claim 1, characterized in that: The reagent storage device (20) has a plurality of storage cavities (21) arranged along a first direction (X), and each storage cavity (21) extends along a second direction (Y) intersecting the first direction (X); The reagent storage device (20) further comprises a plurality of reagent hole groups (22), all of the reagent hole groups (22) being arranged in sequence along the first direction (X) and corresponding one-to-one to all of the storage cavities (21); all of the reagent holes (221) in each group of the reagent hole groups (22) being arranged along the second direction (Y), and all of the reagent holes (221) in the same group of the reagent hole groups (22) being connected to the storage cavity (21) corresponding to the reagent hole group (22).

9. The sample analyzer according to claim 1, characterized in that: The outer disk mechanism (11) comprises an outer disk (111) and an outer disk driving unit (112), the outer disk (111) being drivingly connected to the outer disk driving unit (112), and the outer disk (111) being used to carry and transport the reaction container (2) after sample addition.

10. The sample analyzer according to claim 9, characterized in that: The reaction device (10) further comprises an inner disk mechanism (12), wherein the inner disk mechanism (12) comprises a constant temperature seat (121), a first disk assembly (122) and a second disk assembly (123); The first disk assembly (122) comprises a first disk (1221) and a first driving unit (1222); the first disk (1221) is arranged on the thermostatic seat (121) and is in driving connection with the first driving unit (1222); the second disk assembly (123) comprises a second disk (1231) and a second driving unit (1232); the second disk (1231) is arranged on the thermostatic seat (121) and is arranged around the outer circumference of the first disk (1221); the second disk (1231) is in driving connection with the second driving unit (1232); the outer disk (111) is arranged around the outer circumference of the second disk (1231); the first disk (1221) and the second disk (1231) are both used for carrying the reaction container (2) after mixing; and the thermostatic seat (121) is used for providing a constant temperature reaction environment for the reaction container (2).

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