Cell freezing box

Abstract

The utility model provides a cell freezing box, and belongs to the technical field of cell cryopreservation. According to the technical scheme, the packaging box comprises an outer box, a box cover and an inner box arranged in the outer box; the outer box is a cylinder internally provided with a cavity and provided with an opening in the upper end, the box cover is connected with the outer box through a threaded structure, and the inner box comprises a plurality of cryopreservation tube containing cavities; an upper rotating part is fixedly arranged in the middle of the upper end face of the box cover and comprises a cylindrical block, and a plurality of first protruding clamping blocks are arranged on the peripheral arc face of the cylindrical block along the circumference. A lower rotating part is arranged on the periphery of the outer box and located on the upper side, close to the box cover, of the outer box, the lower rotating part comprises a circular ring fixedly arranged on the periphery of the outer box, and a plurality of protruding second clamping blocks are arranged on the outer side face of the circular ring along the circumference. The freezing box has the advantages that the freezing box is simple in structure and convenient to operate, on one hand, the problem that the box cover is not easy to open due to freezing is solved, and on the other hand, the frostbite risk caused by directly rotating the box cover with hands is avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of cell freezing, in particular to a cell freezing box. Background Art

[0002] With the development of biological technology, cell therapy is developing rapidly and being increasingly accepted by people around the world. The main principle of cell therapy is to obtain living cells from tissues, culture and expand them in vitro for the treatment of diseases. After cell expansion and culture, cells need to be stored to ensure short-term or long-term preservation of cells. During the preservation process, the activity and biological activity of cells determine the effect of cell therapy on diseases, which is a key link in the production and storage of cells.

[0003] With the development of cell culture and cryopreservation technology, cryopreservation containers have emerged in various specifications, especially the most widely used gradient cooling box, which provides a repeatable cooling rate of -1°C / minute, can be applied to a variety of cryogenic tubes and sample bottles, and can provide low-cost cell cryopreservation and recovery. However, the external structure of this gradient cooling box is designed as a general rotating cover design. When the gradient cooling box is directly frozen in a low-temperature refrigerator, especially when the gradient cooling box is placed in a -80°C refrigerator for freezing, its rotating cover is difficult to open and inconvenient to use. In addition, there is a risk of frostbite to the operator when the rotating cover is opened directly by hand, which is not conducive to cell transfer.

[0004] To this end, this application document provides a cell freezing box. Utility Model Content

[0005] The utility model aims to provide a cell freezing box which is simple to operate, easy to open the box cover 2 and can prevent the operator from getting frostbite.

[0006] The utility model is achieved through the following measures:

[0007] A cell freezing box, characterized in that it comprises an outer box, a box cover and an inner box arranged inside the outer box;

[0008] The outer box is a cylindrical body with a cavity inside and an opening at the upper end. The box cover is connected to the outer box through a threaded structure. The box cover is used to seal the outer box. The inner box includes a plurality of cryotube accommodating cavities, and the cross section of the cryotube accommodating cavities is circular.

[0009] An upper rotating part is fixedly arranged in the middle of the upper end surface of the box cover, and the upper rotating part includes a cylindrical block, and a plurality of protruding clamping blocks are arranged along the circumference on the outer arc surface of the cylindrical block;

[0010] A downward rotating part is arranged on the periphery of the outer box, and the downward rotating part is located on the upper side of the outer box close to the box cover. The downward rotating part includes a circular ring fixedly arranged on the periphery of the outer box, and a plurality of protruding blocks 2 are arranged along the circumference on the outer surface of the circular ring.

[0011] The specific features of the utility model also include:

[0012] It also includes an upward rotating piece used in conjunction with the upward rotating part, the upward rotating piece includes a handle, the end of the handle is provided with a circular ring piece whose inner diameter matches the outer diameter of the cylindrical block, and the inner arc surface of the circular ring piece is provided with a plurality of grooves that match the clamping block along the circumference, and the clamping block is clamped in the corresponding groove when in use.

[0013] It also includes a downward rotating component used in conjunction with the downward rotating part, the downward rotating component includes a handle 2, the end of the handle 2 is provided with a circular ring component 2 whose inner diameter matches the outer diameter of the circular ring, and a plurality of clamping grooves 2 that match the clamping block 2 are provided along the circumference on the inner arc surface of the circular ring component 2, and the clamping block 2 is clamped in the corresponding clamping groove 2 when in use.

[0014] A through hole is provided on the end face of the handle, and the through hole penetrates the corresponding card slot and is located in the middle of the card slot. An insertion rod is slidably provided in the through hole, and a plurality of the card blocks are provided with a slot that cooperates with the insertion rod in the middle. When in use, the inner end of the insertion rod is inserted into the corresponding slot, so that the upper rotating member can be prevented from detaching when the box cover is rotated by the upper rotating member.

[0015] A transverse plate is provided at the outer end of the insertion rod away from the circular ring member, and springs are provided on the inner side surfaces of the transverse plate on both sides of the insertion rod, and the other end of the spring is provided on the end surface of the handle. The insertion rod can be kept in the corresponding slot by the action of the spring, and the insertion rod can be separated from the corresponding slot by pulling the transverse plate outward.

[0016] A through hole 2 is provided on the end face of the second handle, and the through hole 2 penetrates the corresponding second card slot and is located in the middle of the second card slot. A plug rod 2 is slidably provided in the second through hole, and a plurality of the second card blocks are provided in the middle with a slot 2 that cooperates with the plug rod 2. When in use, the inner end of the plug rod 2 is inserted into the corresponding slot 2, so that when the box cover is rotated by the cooperation of the lower rotating member and the upper rotating member, the upper rotating member can be prevented from detaching. In addition, the cell freezing box can be taken out of the refrigerator through the lower rotating member, avoiding the risk of frostbite when directly operating by hand.

[0017] A second horizontal plate is provided at the outer end of the second insertion rod away from the second circular ring member, and two springs are provided on the inner side surfaces of the second horizontal plate on both sides of the second insertion rod, and the other end of the second spring is provided on the end surface of the second handle. The second insertion rod can be kept in the corresponding second slot by the action of the second spring, and the second insertion rod can be separated from the corresponding second slot by pulling the second horizontal plate outward.

[0018] In the initial state, the cell freezing box is placed in a refrigerator for frozen storage, and the upper rotating part and the lower part are placed outside the refrigerator for standby use. When it is necessary to take out the cell freezing box, first pull the horizontal plate 2 on the lower rotating part so that the plug rod 2 enters the through hole 2, then the lower rotating part is sleeved on the periphery of the lower rotating part so that the block 2 is stuck in the slot 2, then release the horizontal plate 2 so that the plug rod 2 is inserted into the corresponding slot 2, then the cell freezing box is taken out of the refrigerator through the handle 2, so that the risk of frostbite caused by directly taking out the cell freezing box by hand is avoided, then the upper rotating part is sleeved on the periphery of the upper rotating part so that the block 1 is stuck in the slot 1, and at the same time, the plug rod 1 is inserted into the slot 1 by operating the horizontal plate 1, then the two hands are respectively held on the handle 1 and the handle 2 and the two hands cooperate to rotate in the opposite direction until the box cover is rotated open. This solution solves the problem that the box cover is not easy to open due to freezing on the one hand, and also avoids the risk of frostbite caused by directly rotating the box cover by hand.

[0019] The beneficial effects of the utility model are as follows: the solution has a simple structure and is easy to operate. On the one hand, it solves the problem that the box cover is difficult to open due to freezing, and on the other hand, it avoids the risk of frostbite caused by directly rotating the box cover by hand. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 The utility model is a schematic diagram of the overall structure of the embodiment of the utility model with the upper rotating member and the lower rotating member.

[0021] Figure 2 It is a schematic diagram of an explosion of a freezing box in an embodiment of the utility model.

[0022] Figure 3 It is a structural schematic diagram of the upper rotating member in the embodiment of the utility model.

[0023] Figure 4 It is a structural schematic diagram of the downward rotating member in the embodiment of the utility model.

[0024] Among them, the figures are marked as follows: 1. outer box; 2. box cover; 3. cylindrical block; 4. circular ring piece 1; 5. handle 1; 6. handle 2; 7. circular ring piece 2; 8. slot 1; 9. clamping block 1; 10. freezing tube accommodating chamber; 11. circular ring; 12. clamping block 2; 13. slot 2; 14. clamping slot 1; 15. insertion rod 1; 16. spring 1; 17. horizontal plate 1; 18. clamping slot 2; 19. insertion rod 2; 20. spring 2; 21. horizontal plate 2. DETAILED DESCRIPTION

[0025] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments can be combined with each other.

[0026] In the description of the present utility model, it should be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present utility model. In addition, the terms "first", "second", etc. are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, features defined as "first", "second", etc. may explicitly or implicitly include one or more of the features. In the description of the present utility model, unless otherwise specified, "multiple" means two or more.

[0027] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installation", "connection" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood by specific circumstances.

[0028] In order to clearly illustrate the technical features of this solution, this solution is described below through a specific implementation method.

[0029] See also Figure 1-4 , a cell freezing box, comprising an outer box 1, a box cover 2 and an inner box arranged inside the outer box 1;

[0030] The outer box 1 is a cylindrical body with a cavity inside and an opening at the upper end. The box cover 2 is connected to the outer box 1 through a threaded structure. The box cover 2 is used to seal the outer box 1. The inner box includes a plurality of cryotube accommodating cavities 10. The cross section of the cryotube accommodating cavities 10 is circular.

[0031] An upper rotating part is fixedly arranged in the middle of the upper end surface of the box cover 2, and the upper rotating part includes a cylindrical block 3, and a plurality of protruding clamping blocks 9 are arranged along the circumference on the outer arc surface of the cylindrical block 3;

[0032] A lower rotating part is arranged on the periphery of the outer box 1, and the lower rotating part is located on the upper side of the outer box 1 close to the box cover 2. The lower rotating part includes a circular ring 11 fixedly arranged on the periphery of the outer box 1, and a plurality of protruding blocks 12 are arranged on the outer surface of the circular ring 11 along the circumference.

[0033] It also includes an upper rotating member used in conjunction with the upper rotating part, the upper rotating member includes a handle 5, the end of the handle 5 is provided with a circular ring member 4 whose inner diameter matches the outer diameter of the cylindrical block 3, and a plurality of clamping grooves 14 matching with the clamping block 9 are provided along the circumference on the inner arc surface of the circular ring member 4. When in use, the clamping block 9 is clamped in the corresponding clamping groove 14.

[0034] It also includes a downward rotating member used in conjunction with the downward rotating part, and the downward rotating member includes a handle 2 6. The end of the handle 2 6 is provided with a circular ring member 7 whose inner diameter matches the outer diameter of the circular ring 11. A plurality of clamping grooves 2 18 matching the clamping block 2 12 are provided along the circumference on the inner arc surface of the circular ring member 7. When in use, the clamping block 2 12 is clamped in the corresponding clamping groove 2 18.

[0035] A through hole 1 is provided on the end surface of the handle 5, and the through hole 1 passes through the corresponding card slot 14 and is located in the middle of the card slot 14. A plug rod 15 is slidably provided in the through hole 1, and a plurality of card blocks 9 are provided in the middle thereof with a slot 8 cooperating with the plug rod 15. When in use, the inner end of the plug rod 15 is inserted into the corresponding slot 8, so that when the box cover 2 is rotated by the upper rotating member, the upper rotating member can be prevented from being detached.

[0036] A transverse plate 17 is provided at the outer end of the insertion rod 15 away from the circular ring member 4, and springs 16 are provided on the inner side surfaces of the transverse plate 17 on both sides of the insertion rod 15. The other end of the spring 16 is provided on the end surface of the handle 5. The insertion rod 15 can be kept in the corresponding slot 8 by the action of the spring 16, and the insertion rod 15 can be separated from the corresponding slot 8 by pulling the transverse plate 17 outward.

[0037] A through hole 2 is provided on the end face of the handle 2 6, and the through hole 2 passes through the corresponding card slot 2 18 and is located in the middle of the card slot 2 18. An insertion rod 2 19 is slidably provided in the through hole 2, and a plurality of card blocks 2 12 are provided in the middle with a slot 2 13 cooperating with the insertion rod 2 19. When in use, the inner end of the insertion rod 2 19 is inserted into the corresponding slot 2 13, so that when the box cover 2 is rotated by the cooperation of the lower rotating member and the upper rotating member, the upper rotating member can be prevented from detaching. In addition, the cell freezing box can be taken out of the refrigerator through the lower rotating member, avoiding the risk of frostbite when directly operating by hand.

[0038] A horizontal plate 21 is provided at the outer end of the insertion rod 19 away from the circular ring member 7, and springs 20 are provided on the inner side surfaces of the horizontal plate 21 on both sides of the insertion rod 19. The other end of the spring 20 is provided on the end surface of the handle 6. The insertion rod 19 can be kept in the corresponding slot 13 by the action of the spring 20. In addition, the insertion rod 19 can be separated from the corresponding slot 13 by pulling the horizontal plate 21 outward.

[0039] In the initial state, the cell freezing box is placed in a refrigerator for frozen storage, while the upper rotating part and the lower part are placed outside the refrigerator for standby use. When it is necessary to take out the cell freezing box, first pull the horizontal plate 21 on the lower rotating part to make the insertion rod 21 enter the through hole 2, then put the lower rotating part on the outer periphery of the lower rotating part, so that the clamping block 21 is stuck in the clamping groove 218, then loosen the horizontal plate 21, so that the insertion rod 219 is inserted into the corresponding slot 213, and then take the cell freezing box out of the refrigerator through the handle 26, thus avoiding the risk of frostbite caused by directly taking out the cell freezing box by hand, and then put the upper rotating part on the outer periphery of the upper rotating part, so that the clamping block 9 is stuck in the clamping groove 14, and at the same time, the insertion rod 15 is inserted into the slot 8 by operating the horizontal plate 17, and then both hands hold the handle 15 and the handle 26 respectively and rotate them in opposite directions until the box cover 2 is rotated open. On the one hand, this solution solves the problem that the box cover 2 is not easy to open due to freezing, and on the other hand, it also avoids the risk of frostbite caused by directly rotating the box cover 2 by hand.

[0040] Technical features not described in the present invention can be achieved through or by adopting existing technologies, and will not be elaborated here. Of course, the above description is not a limitation of the present invention, and the present invention is not limited to the above examples. Changes, modifications, additions or substitutions made by ordinary technicians in this technical field within the essential scope of the present invention should also fall within the scope of protection of the present invention.

Claims

1. A cell freezing box, characterized in that: It comprises an outer box (1), a box cover (2), and an inner box arranged inside the outer box (1); The outer box (1) is a cylindrical body with a cavity inside and an opening at the upper end; the box cover (2) is connected to the outer box (1) via a threaded structure; and the inner box comprises a plurality of cryotube accommodating cavities (10); An upper rotating portion is fixedly arranged in the middle of the upper end surface of the box cover (2), and the upper rotating portion comprises a cylindrical block (3), and a plurality of protruding clamping blocks (9) are arranged along the circumference on the outer arc surface of the cylindrical block (3); The outer box (1) is provided with a downward rotating portion on its periphery, the downward rotating portion being located on the upper side of the outer box (1) close to the box cover (2), the downward rotating portion comprising a circular ring (11) fixedly arranged on the outer periphery of the outer box (1), and a plurality of protruding clamping blocks (12) being arranged along the circumference on the outer side surface of the circular ring (11).

2. The cell freezing box according to claim 1, characterized in that: It also includes an upward rotating member used in conjunction with the upward rotating portion, the upward rotating member includes a handle (5), the end of the handle (5) is provided with a circular ring member (4) whose inner diameter matches the outer diameter of the cylindrical block (3), and a plurality of clamping grooves (14) are provided along the circumference on the inner arc surface of the circular ring member (4) to match the clamping block (9).

3. The cell freezing box according to claim 1, characterized in that: It also includes a downward rotating member used in conjunction with the downward rotating part, the downward rotating member includes a handle 2 (6), the end of the handle 2 (6) is provided with a circular ring 2 (7) whose inner diameter matches the outer diameter of the circular ring (11), and a plurality of clamping grooves 2 (18) are provided along the circumference on the inner arc surface of the circular ring 2 (7) to match the clamping block 2 (12).

4. The cell freezing box according to claim 2, characterized in that: A through hole is provided on the end surface of the handle (5), the through hole passes through the corresponding slot (14) and is located in the middle of the slot (14), an insertion rod (15) is slidably arranged in the through hole, and a plurality of the card blocks (9) are provided in the middle with a slot (8) that cooperates with the insertion rod (15).

5. The cell freezing box according to claim 4, characterized in that: A transverse plate (17) is provided at the outer end of the insertion rod (15) away from the circular ring member (4), and springs (16) are provided on the inner side surfaces of both sides of the transverse plate (17) of the insertion rod (15), and the other end of the spring (16) is provided on the end surface of the handle (5).

6. The cell freezing box according to claim 3, characterized in that: A through hole 2 is arranged on the end surface of the handle 2 (6), the through hole 2 passes through the corresponding clamping slot 2 (18) and is located in the middle of the clamping slot 2 (18), an insertion rod 2 (19) is slidably arranged in the through hole 2, and a plurality of the clamping blocks 2 (12) are each provided in the middle with a slot 2 (13) matched with the insertion rod 2 (19).

7. The cell freezing box according to claim 6, characterized in that: A second transverse plate (21) is arranged at the outer end of the second insertion rod (19) away from the second circular ring member (7), and a second spring (20) is arranged on the inner side surface of the second transverse plate (21) located on both sides of the second insertion rod (19), and the other end of the second spring (20) is arranged on the end surface of the second handle (6).

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