Reaction kettle for producing sacubitril valsartan sodium

Abstract

The utility model discloses a reaction kettle for producing sacubatrivalsartan sodium, which comprises a reaction kettle body, a filter screen frame is arranged in the reaction kettle body, a filter screen is fixedly mounted in the filter screen frame, a power motor is fixedly mounted on the reaction kettle body, a transmission rod is fixedly mounted at the output end of the power motor, and the transmission rod is fixedly mounted on the reaction kettle body. An arc-shaped scraping plate is fixedly mounted at the lower end of the transmission rod, the arc-shaped scraping plate is matched with the filter screen, the outer wall of the reaction kettle body is sleeved with a heating sleeve shell, a spiral blade is fixedly mounted on the inner wall of the heating sleeve shell, the reaction kettle body comprises an upper-layer reaction kettle and a reaction kettle bottom, and input and output ports are formed in the two sides of the heating sleeve shell in an up-down staggered manner. The power motor is started to drive the arc-shaped scraping plate to rotate, solid products are directly left in the reaction kettle after being filtered by the filter screen, and the arc-shaped scraping plate rotates to continuously sweep solids accumulated on the filter screen to the edge, so that the situation that the solids are accumulated to block the filter screen and influence discharge of liquid medicine is avoided.

Description

Technical Field

[0001] The utility model relates to a reaction kettle, in particular to a reaction kettle for producing sacubitril-valsartan sodium. Background Art

[0002] Sacubitril-valsartan sodium is a co-crystal drug of sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker. It is used to reduce the risk of cardiovascular death and hospitalization for heart failure and reduce ejection fraction in patients with chronic heart failure. A reactor is required during the production process.

[0003] For example, a reaction kettle for producing sacubitril valsartan sodium, disclosed in the Chinese patent publication number CN218924672U, includes a kettle body, a stirring device, a feed port, a discharge port and a discharge valve. A filtering device is provided on the inner wall at the bottom of the kettle body, and a humidity control device and an air inlet are also provided on the upper part of the kettle body. The humidity control device is composed of a humidity sensor, a humidity controller and an air inlet valve. The humidity sensor is fixedly mounted on the upper part of the kettle body and connected to the humidity controller. The air inlet valve is a three-way valve, one end of which is connected to a wet gas source pipeline or / and a dry gas source pipeline, and the other end is connected to the air inlet through an air inlet pipe. A jacket is provided on the outside of the kettle body, and an input port is provided at the lower part of the jacket, and an output port is provided at the upper part of the jacket. The internal temperature of the kettle body is regulated and controlled by inputting or outputting a heat source into the jacket layer.

[0004] Some problems were found during the use of the above-mentioned existing reactor for producing sacubitril valsartan sodium. First, although the filter plate can separate the solid and the liquid, the solids accumulate on the filter plate, which will clog the filter holes, resulting in the speed of drug liquid discharge being affected, and in severe cases, the drug liquid cannot be discharged. Utility Model Content

[0005] The utility model aims to provide a reaction kettle for producing sacubitril-valsartan sodium to solve the existing problems raised in the above background technology.

[0006] To achieve the above-mentioned purpose, the utility model provides the following technical solution: a reactor for producing sacubitril / valsartan sodium, comprising a reactor body, a filter screen frame is arranged in the reactor body, a filter screen is fixedly installed in the filter screen frame, a power motor is fixedly installed on the reactor body, a transmission rod is fixedly installed on the output end of the power motor, an arc-shaped scraper is fixedly installed on the lower end of the transmission rod, the arc-shaped scraper cooperates with the filter screen, a heating shell is sleeved on the outer wall of the reactor body, and a spiral blade is fixedly installed on the inner wall of the heating shell.

[0007] Preferably, the reactor body comprises an upper reactor and a reactor bottom, and a connecting flange is fixedly installed at one end of the upper reactor and the reactor bottom.

[0008] Preferably, input and output ports are staggered up and down on both sides of the heating jacket shell, and the input and output ports are communicated with the interior of the heating jacket shell.

[0009] Preferably, a stirring rod is fixedly mounted on the transmission rod.

[0010] Preferably, a fixing flange is fixedly mounted on the outer wall of the filter frame, and the fixing flange cooperates with the connecting flange.

[0011] Compared with the prior art, the beneficial effects of the utility model are:

[0012] 1. By starting the power motor to drive the arc scraper to rotate, the solid product will be directly left in the reactor after being filtered through the filter. The rotation of the arc scraper will continuously sweep the solids accumulated on the filter to the edge to prevent the solid accumulation from clogging the filter and affecting the discharge of the liquid medicine.

[0013] 2. After the heat source is transported to the interior of the heating jacket through the input and output ports, the heat source will spiral forward inside the heating jacket until it is discharged, increasing the contact time between the heat source and the outer wall of the reactor body, thereby making full use of the heat source and improving the heating efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0015] Figure 2 This is a schematic diagram of the structure of the power motor, reaction kettle bottom, and filter frame of the utility model;

[0016] Figure 3 It is a half-section view of the heating jacket of the utility model.

[0017] In the figure: 1. reactor body; 101. upper reactor; 102. reactor bottom; 103. connecting flange; 2. heating jacket; 201. spiral blade; 202. input and output ports; 3. power motor; 301. transmission rod; 302. stirring rod; 303. arc scraper; 4. filter frame; 401. fixing flange; 402. filter. DETAILED DESCRIPTION

[0018] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0019] See also Figure 1-3The utility model provides a technical solution: a reactor for producing sacubitril valsartan sodium, comprising a reactor body 1, a filter frame 4 is arranged in the reactor body 1, a filter 402 is fixedly installed in the filter frame 4, a power motor 3 is fixedly installed on the reactor body 1, a transmission rod 301 is fixedly installed at the output end of the power motor 3, an arc scraper 303 is fixedly installed at the lower end of the transmission rod 301, the arc scraper 303 and the filter 402 cooperate with each other, a heating jacket 2 is sleeved on the outer wall of the reactor body 1, and a spiral blade 201 is fixedly installed on the inner wall of the heating jacket 2.

[0020] In this embodiment, the arc scraper 303 cooperates with the filter screen 402, the filter screen 402 is attached to the arc scraper 303, and the power motor 3 is started to drive the transmission rod 301 to rotate. The rotation of the transmission rod 301 will drive the arc scraper 303 to rotate, and the arc scraper 303 will move the solids accumulated on the filter screen 402. Since the arc scraper 303 is arc-shaped, Figure 2 As shown, when the arc scraper 303 rotates and moves the solid, the solid will be moved to the edge of the arc scraper 303, so that the center of the arc scraper 303 can still filter the liquid medicine normally, avoiding the arc scraper 303 from being completely blocked. At the same time, a spiral blade 201 is set on the inner wall of the heating shell 2. After the heat source is transported into the heating shell 2, the heat source will spirally move forward in the heating shell 2 until it is discharged, thereby increasing the contact time between the heat source and the outer wall of the reactor body 1, thereby making full use of the heat source.

[0021] Among them, in order to achieve the purpose of fixing the upper reactor 101 and the reactor bottom 102, the present device adopts the following technical solution: the reactor body 1 includes the upper reactor 101 and the reactor bottom 102, and one end of the upper reactor 101 and the reactor bottom 102 are fixedly installed with a connecting flange 103, and the two sides of the heating jacket 2 are staggered up and down with input and output ports 202, and the input and output ports 202 are communicated with the interior of the heating jacket 2.

[0022] The upper reactor 101 and the reactor bottom 102 can be fixed together by bolts through the connecting flange 103. The reactor body 1 can be disassembled by unscrewing the bolts, which is convenient for the later maintenance and replacement of the internal filter screen, stirring blades, etc. The input and output ports 202 are located on both sides of the heating jacket 2 and are staggered up and down. The heat source can be input through one input and output port 202 and output through the other input and output port 202, so as to heat the reactor body 1 to a suitable temperature.

[0023] In order to fix the filter frame 4, the device is implemented by the following technical solution: a stirring rod 302 is fixedly installed on the transmission rod 301, a fixing flange 401 is fixedly installed on the outer wall of the filter frame 4, and the fixing flange 401 cooperates with the connecting flange 103.

[0024] The transmission rod 301 can drive the stirring rod 302 to rotate, and the stirring rod 302 will stir the internal liquid medicine. The fixed flange 401 and the connecting flange 103 cooperate with each other. The fixed flange 401 is located between the two connecting flanges 103. By using bolts to fix the upper reactor 101 and the reactor bottom 102 together, the filter frame 4 can be fixed inside the reactor body 1.

[0025] The working principle and use process of the utility model are as follows: when using, the device needs to be placed in a suitable position, and the heat source is discharged into the interior of the heating shell 2 through the input and output ports 202, the reactor body 1 is controlled to a suitable temperature, and then the raw materials are put into the device through the feed port at the upper end of the reactor body 1, and the power motor 3 is started to drive the stirring rod 302 to rotate, so that the internal liquid medicine is repeatedly mixed together, and as the reaction proceeds, the generated sacubitril valsartan sodium will precipitate in the form of precipitation, and when the reaction is completed, the discharge valve is opened to discharge the mixed liquid, and the solid product is directly left in the reactor after being filtered through the filter screen 402, and the rotation of the arc scraper 303 will continuously sweep the solids accumulated on the filter screen 402 to the edge to prevent the solid accumulation from clogging the filter screen 402.

[0026] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A reactor for producing sacubitril / valsartan sodium, comprising a reactor body (1), characterized in that: A filter frame (4) is arranged inside the reaction kettle body (1), a filter (402) is fixedly installed inside the filter frame (4), a power motor (3) is fixedly installed on the top of the reaction kettle body (1), a transmission rod (301) is fixedly installed on the output end of the power motor (3), an arc-shaped scraper (303) is fixedly installed on the lower end of the transmission rod (301), the arc-shaped scraper (303) and the filter (402) cooperate with each other, the outer wall of the reaction kettle body (1) is sleeved with a heating shell (2), and the inner wall of the heating shell (2) is fixedly installed with a spiral blade (201).

2. A reactor for producing sacubitril-valsartan sodium according to claim 1, characterized in that: The reactor body (1) comprises an upper reactor (101) and a reactor bottom (102), and a connecting flange (103) is fixedly mounted on one end of the upper reactor (101) and the reactor bottom (102).

3. A reactor for producing sacubitril-valsartan sodium according to claim 1, characterized in that: Input and output ports (202) are staggered up and down on both sides of the heating jacket shell (2), and the input and output ports (202) are communicated with the interior of the heating jacket shell (2).

4. A reactor for producing sacubitril-valsartan sodium according to claim 1, characterized in that: A stirring rod (302) is fixedly mounted on the transmission rod (301).

5. A reactor for producing sacubitril-valsartan sodium according to claim 2, characterized in that: A fixing flange (401) is fixedly mounted on the outer wall of the filter frame (4), and the fixing flange (401) and the connecting flange (103) cooperate with each other.

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