Dropwise adding device for fluorescent reagent detection
By introducing sliding components and screws into the dropping device for fluorescence immunoassay, the problem of inaccurate dropping caused by the inclination of the dropper is solved, the accuracy of dropping and the convenience of operation are achieved, and the reliability of the detection results are ensured.
Patent Information
- Application Number
- CN202421380474.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-06-17
- Publication Date
- 2024-12-17
- Estimated Expiration
- 2034-06-17
AI Technical Summary
The existing reagent dropping device for fluorescence immunoassay cannot ensure that the reagent liquid level is aligned with the scale line when the dropper is inclined, resulting in inaccurate dropping, resulting in waste of reagents or inaccurate detection results.
A drip device including a placing seat, a guide rod, a sliding assembly and a screw is designed. Through the cooperation of the sliding assembly and the screw, the height and position of the dropper can be adjusted and fixed, prevented from tilting, and realize the dropper through the sliding seat. Quickly switch to ensure the accuracy of drops.
It effectively prevents fluorescent reagents from splashing, ensures the quantitative and accuracy of droplet addition, makes operation more convenient, and reduces reagent waste and inaccuracy of detection results.
Smart Images
Figure CN222174122U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the field of reagent dropping equipment, in particular to a dropping device for fluorescent reagent detection. Background Art
[0002] Fluorescence immunoassay is a commonly used immunoassay method that uses specific antibodies to bind to antigens and then uses fluorescently labeled secondary antibodies or probes to detect and quantify the target. It combines the advantages of immunology and fluorescence technology, with high sensitivity, high specificity and a wide range of applications.
[0003] When performing fluorescent immunoassay, most of the time, a dropping device is used. The dropping device generally uses a relatively simple and easy-to-control device to ensure accurate dropping of reagents and avoid overdosage or underdosage.
[0004] The existing reagent dropping device for fluorescent immunoassay cannot ensure that the dropper remains in a vertical state when dropping reagents such as proteins, hormones, drugs and microorganisms. Once the dropper is tilted, it is easy to cause the reagent liquid level in the dropper to no longer be aligned with the scale line. In this case, the added reagent cannot be accurately quantified during dropping. Too much reagent dropping will lead to reagent waste, and too little reagent dropping will lead to inaccurate test results. Therefore, a fluorescent reagent dropping device is proposed to solve the above problems. Utility Model Content
[0005] In order to make up for the above shortcomings, the utility model provides a dropping device for fluorescent reagent detection, which aims to improve the problem in the prior art that once the dropper is tilted, the reagent liquid level in the dropper is easily no longer aligned with the scale line, so that the added reagent cannot be accurately quantified during dropping.
[0006] In order to achieve the above-mentioned purpose, the utility model adopts the following technical scheme: a drop-adding device for fluorescent reagent detection, comprising a placing seat, the top end of the outer wall of the placing seat is fixedly connected to a guide rod, the outer wall of the guide rod is provided with a sliding assembly, the sliding assembly comprises a movable plate, the inner wall of the movable plate is elastically connected to an insert block through a limit spring, the end of the movable plate away from the guide rod is provided with a guide assembly, the inner wall of the guide assembly is provided with a sliding seat, and the inner wall of the sliding seat is detachably mounted with a dropper through a screw.
[0007] As a further description of the above technical solution:
[0008] The guide assembly comprises a guide seat, and the inner wall of the guide seat is elastically connected to a limiting ball via a return spring.
[0009] As a further description of the above technical solution:
[0010] The inner side wall of the movable plate is slidably connected to the outer wall of the guide rod, one end of the limit spring is fixedly connected to the surface of the insert block, and the other end of the limit spring is fixedly connected to the inner wall of the movable plate.
[0011] As a further description of the above technical solution:
[0012] The insert block penetrates and is slidably connected to the inner wall of the moving plate. The inner side wall of the guide rod is provided with a plurality of through holes, and the insert block is plugged into the inner wall of the through hole.
[0013] As a further description of the above technical solution:
[0014] The screw is threadedly connected to the inner wall of the sliding seat, and the bottom end of the outer wall of the screw is in contact with the outer wall of the dropper.
[0015] As a further description of the above technical solution:
[0016] One end of the return spring is fixedly connected to the inner wall of the guide seat, and the other end of the return spring is fixedly connected to the bottom end of the outer wall of the limiting ball.
[0017] As a further description of the above technical solution:
[0018] The limiting ball is slidably connected to the inner wall of the guide seat, the outer wall of the movable plate is fixedly connected to the outer wall of the guide seat, the inner wall of the guide seat is provided with a guide rail, and the sliding seat is slidably connected to the inner wall of the guide rail.
[0019] As a further description of the above technical solution:
[0020] The outer wall of the sliding seat is provided with two groups of ball grooves, and the top of the outer wall of the limiting ball contacts the inner wall of the ball groove.
[0021] The utility model has the following beneficial effects:
[0022] 1. In the utility model, by providing a sliding component, when dripping the detection object, the movable plate can be driven to rise or fall by pulling the plug block, so that the dropper can be adjusted according to the height of the detected object, thereby preventing the fluorescent reagent from splashing due to excessive height, and by providing a screw, droppers of different thicknesses can be fixed and their positions can be kept stable to prevent them from tilting.
[0023] 2. In the utility model, a sliding seat is provided and two groups of through holes are provided inside the sliding seat. When the dosage of a tube of fluorescent reagent is insufficient during the detection process, the sliding seat can be directly pushed to switch the two groups of droppers, which is more convenient and quick to operate. Cross infection will not occur when the dropper is used to extract new fluorescent reagent. BRIEF DESCRIPTION OF THE DRAWINGS
[0024] Figure 1 This is an overall three-dimensional schematic diagram of a fluorescent reagent detection dropping device proposed by the utility model;
[0025] Figure 2 This is a schematic rear view of the whole of a fluorescent reagent detection dropping device proposed by the utility model;
[0026] Figure 3 This is a partial cross-sectional schematic diagram of a moving plate and a guide seat of a fluorescent reagent detection dropping device proposed by the utility model;
[0027] Figure 4 The utility model provides a fluorescent reagent detection dropping device Figure 3 The enlarged schematic diagram of part A in the middle;
[0028] Figure 5 The utility model provides a partial cross-sectional schematic diagram of a sliding seat of a fluorescent reagent detection dropping device.
[0029] Legend:
[0030] 1. Placement seat; 2. Guide rod; 3. Sliding assembly; 31. Moving plate; 32. Limiting spring; 33. Insert block; 4. Guide assembly; 41. Guide seat; 42. Return spring; 43. Limiting ball; 5. Sliding seat; 6. Dropper; 7. Screw. DETAILED DESCRIPTION
[0031] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.
[0032] Reference Figure 1-Figure 3The utility model provides an embodiment: a fluorescent reagent detection drop adding device, comprising a placement seat 1, a guide rod 2 is fixedly connected to the top of the outer wall of the placement seat 1, and a guide groove is provided on the outer wall of the guide rod 2 to fit the inner wall of the moving plate 31, so that the moving plate 31 can only move up and down on the inner wall of the guide rod 2, and cannot rotate. The outer wall of the guide rod 2 is provided with a sliding assembly 3, and the sliding assembly 3 includes a moving plate 31, and the inner side wall of the moving plate 31 is slidably connected to the outer wall of the guide rod 2. The moving plate 31 moves up and down on the surface of the guide rod 2, so that the height of the dropper 6 can be adjusted according to the height of the test cup, so as to prevent the fluorescent reagent from splashing when it falls into the test cup. The inner wall of the moving plate 31 is elastically connected with an insert block 33 through a limit spring 32, one end of the limit spring 32 is fixedly connected to the surface of the insert block 33, and the other end of the limit spring 32 is fixedly connected to the inner wall of the moving plate 31. The setting of the limit spring 32 is such that there is no need to manually reset when pulling the insert block 33, that is, it can be automatically reset by the elastic action of the limit spring 32.
[0033] Reference Figure 2-Figure 5 The plug block 33 penetrates and is slidably connected to the inner wall of the movable plate 31. The inner side wall of the guide rod 2 is provided with multiple groups of through holes. The plug block 33 is plugged into the inner wall of the through hole. The plugging between the two fixes the movable plate 31 at multiple positions of the upper and lower movement of the surface of the guide rod 2, so that the height of the dropper 6 can be adjusted. The end of the movable plate 31 away from the guide rod 2 is provided with a guide component 4. The inner wall of the guide component 4 is provided with a sliding seat 5. The inner wall of the sliding seat 5 is provided with two groups of empty grooves for placing the dropper 6. Thereby, two groups of droppers 6 can be installed and fixed at the same time. The inner wall of the sliding seat 5 is detachably installed with the dropper 6 through the screw 7. The screw 7 is threadedly connected to the inner wall of the sliding seat 5. The bottom end of the outer wall of the screw 7 contacts the outer wall of the dropper 6. The two are in contact, so that the lower screw 7 moves on the inner wall of the sliding seat 5, thereby contacting the outer wall of the dropper 6, thereby squeezing the position of the dropper 6 to prevent it from tilting. At the same time, the droppers 6 of different thicknesses can also be pressed and fixed.
[0034] Reference Figure 4-Figure 5The guide assembly 4 includes a guide seat 41, the inner wall of the guide seat 41 is elastically connected to the limiting ball 43 through a return spring 42, and the outer wall of the sliding seat 5 is provided with two sets of ball grooves, and the top of the outer wall of the limiting ball 43 contacts the inner wall of the ball groove, and the contact between the two fixes the positions of the two sets of droppers 6 moving in the guide seat 41, and the setting of the ball groove prevents the sliding seat 5 from moving without the influence of external force, one end of the return spring 42 is fixedly connected to the inner wall of the guide seat 41, and the other end of the return spring 42 is fixedly connected to the outer wall of the limiting ball 43 At the bottom end, the function of the reset spring 42 is to elastically reset the limiting ball 43 after it is squeezed and moved, the limiting ball 43 is slidably connected to the inner wall of the guide seat 41, the outer wall of the movable plate 31 is fixedly connected to the outer wall of the guide seat 41, the inner wall of the guide seat 41 is provided with a guide rail, and the sliding seat 5 is slidably connected to the inner wall of the guide rail. The sliding seat 5 can be disassembled from the inner wall of the guide seat 41 to facilitate the installation of the dropper 6, and it is also possible to switch between the two groups of droppers 6, so as to prevent the dropper 6 from having insufficient fluorescent agent dosage when it is used directly.
[0035] Working principle: When adding fluorescent reagent to the object to be detected, the fluorescent reagent can be first extracted from its inner wall by grabbing the dropper 6. At this time, two groups of droppers 6 can be placed in two groups of empty grooves inside the sliding seat 5, and the screw 7 can be rotated on the inner wall of the sliding seat 5 so that the bottom end of the screw 7 contacts the outer wall of the dropper 6, thereby fixing the dropper 6. At this time, the sliding seat 5 can be inserted as a whole into the inner wall of the guide rail of the guide seat 41. When the sliding seat 5 enters the inner wall of the guide seat 41, its outer wall will first contact the spherical surface of the limiting ball 43 on the inner wall of the guide seat 41, thereby squeezing it to move on the inner wall of the guide seat 41, and allowing the reset spring 42 to be elastically compressed until the position of the first group of ball grooves of the sliding seat 5, the limiting ball 43 will be elastically acted upon by the reset spring 42, restoring it to its initial position to contact the ball groove at the current position of the sliding seat 5, thereby fixing the position of the sliding seat 5. At this time, the object to be detected can be placed in the empty groove of the placement seat 1.
[0036] After the object to be detected and the dropper 6 are installed, the plug block 33 can be pulled to disengage it from the through hole at the current position of the guide rod 2, and the plug block 33 will cause the limit spring 32 to be elastically compressed during the movement. At this time, the movable plate 31 can be moved up and down on the surface of the guide rod 2 to drive the dropper 6 to adjust according to the height of the object to be detected, thereby preventing the height from being too high, which will cause the fluorescent reagent to splash during the dripping process. When it is adjusted to a suitable position, the plug block 33 is released and it will be elastically acted upon by the limit spring 32 to restore it to its original position to connect with the through hole at the current position of the guide rod 2, thereby fixing the positions of the movable plate 31 and the two groups of droppers 6 inside the sliding seat 5.
[0037] At this time, the rubber ball at the top of the dropper 6 can be directly pressed to allow the fluorescent reagent to fall onto the surface of the object to be detected. After the reagent in the current dropper 6 is used up and the remaining amount of the fluorescent reagent is insufficient, the sliding seat 5 can be directly moved along the inner wall of the guide seat 41. At the same time, during the movement of the sliding seat 5, the inner wall of the ball groove of the corresponding limiting ball 43 will squeeze the arc surface of the limiting ball 43, thereby moving the limiting ball 43 along the inner wall of the guide seat 41 and allowing the reset spring 42 to be elastically compressed until the position of the first group of ball grooves of the sliding seat 5 is reached. The limiting ball 43 will be elastically acted upon by the reset spring 42 to restore it to its initial position to contact the ball groove at the current position of the sliding seat 5, thereby fixing the position where the second group of droppers 6 stay.
[0038] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.
Claims
1. A fluorescent reagent detection dropping device, comprising a placement seat (1), characterized in that: The top end of the outer wall of the placement seat (1) is fixedly connected to a guide rod (2), the outer wall of the guide rod (2) is provided with a sliding assembly (3), and the sliding assembly (3) includes a moving plate (31); The inner wall of the movable plate (31) is elastically connected to an insert block (33) via a limit spring (32); a guide assembly (4) is provided at one end of the movable plate (31) away from the guide rod (2); a sliding seat (5) is provided on the inner wall of the guide assembly (4); and a dropper (6) is detachably mounted on the inner wall of the sliding seat (5) via a screw rod (7).
2. A fluorescent reagent detection dropping device according to claim 1, characterized in that: The guide assembly (4) comprises a guide seat (41), the inner wall of the guide seat (41) being elastically connected to a limiting ball (43) via a return spring (42).
3. A fluorescent reagent detection dropping device according to claim 1, characterized in that: The inner side wall of the movable plate (31) is slidably connected to the outer wall of the guide rod (2), one end of the limit spring (32) is fixedly connected to the surface of the plug block (33), and the other end of the limit spring (32) is fixedly connected to the inner wall of the movable plate (31).
4. A fluorescent reagent detection dropping device according to claim 1, characterized in that: The insert block (33) penetrates through and is slidably connected to the inner wall of the movable plate (31); the inner side wall of the guide rod (2) is provided with a plurality of through holes, and the insert block (33) is plugged into the inner wall of the through hole.
5. A fluorescent reagent detection dropping device according to claim 1, characterized in that: The screw rod (7) is threadedly connected to the inner wall of the sliding seat (5), and the bottom end of the outer wall of the screw rod (7) is in contact with the outer wall of the dropper (6).
6. A fluorescent reagent detection dropping device according to claim 2, characterized in that: One end of the return spring (42) is fixedly connected to the inner wall of the guide seat (41), and the other end of the return spring (42) is fixedly connected to the bottom end of the outer wall of the limiting ball (43).
7. A fluorescent reagent detection dropping device according to claim 2, characterized in that: The limiting ball (43) is slidably connected to the inner wall of the guide seat (41), the outer wall of the movable plate (31) is fixedly connected to the outer wall of the guide seat (41), the inner wall of the guide seat (41) is provided with a guide rail, and the sliding seat (5) is slidably connected to the inner wall of the guide rail.
8. A fluorescent reagent detection dropping device according to claim 2, characterized in that: The outer wall of the sliding seat (5) is provided with two groups of ball grooves, and the top end of the outer wall of the limiting ball (43) contacts the inner wall of the ball groove.