Controllable flexible pressing device applied to microneedle patch skin surface drug delivery

Abstract

The utility model discloses a controllable flexible pressing device applied to microneedle patch skin surface drug delivery, and belongs to the technical field of drug delivery, the controllable flexible pressing device comprises a microneedle patch, an electrostatic adsorption membrane, a rigid support body, an air bag and a thin film pressure sensor, the microneedle patch is attached to the skin surface, and a needle head is downward; the electrostatic adsorption membrane is arranged above the microneedle patch; the rigid support body is arranged on the electrostatic adsorption membrane, and an air bag mounting cavity is formed in the middle of the rigid support body; the air bag is arranged in the air bag mounting cavity; and the thin film pressure sensor covers the air bag. The device is simple in structure and convenient to operate, the application direction, the change rate, the magnitude and the action time of force in the dosing process can be controlled, the penetration depth of the microneedle is influenced, and then the positive influence on the experimental result and the clinical effect is generated.

Description

Technical Field

[0001] The utility model relates to the technical field of drug delivery, and in particular to a controllable flexible pressing device used for drug delivery on the skin surface of a microneedle patch. Background Art

[0002] In the past two decades, microneedles have received widespread attention as a new drug delivery system. With the development of technology, microneedles have been used to deliver drugs or vaccines to the skin, eyes, mouth, blood vessels and other parts. Microneedles are microarrays composed of one or more micron-level needle tips, and the needle tip height is generally between 25 and 2000μm. Microneedles can break the physiological barrier and deliver drugs directly to the submucosal tissue. Compared with the traditional transmucosal drug delivery method, microneedle drug delivery can increase drug permeability and achieve efficient local or systemic drug delivery. Due to the small size of the microneedle, it will not stimulate the nerves during the transmucosal drug delivery process. Compared with subcutaneous injection, microneedle drug delivery is painless and minimally invasive, which can improve patient compliance and avoid needle fear. In addition, microneedle drug delivery is simple to operate, and patients can carry out treatment on their own.

[0003] When administering drugs through microneedle patches, a certain force needs to be applied to the tissue surface at the patch. The direction, rate of change, magnitude, and duration of the force will directly affect the depth of microneedle penetration into the tissue, and thus affect drug delivery and release. Therefore, it is necessary to provide a quantifiable and appropriate force when applying the drug to the skin surface of different individuals so that the microneedle reaches the preset delivery position. Utility Model Content

[0004] The purpose of the utility model is to provide a controllable flexible pressing device for microneedle patch skin surface drug delivery to solve the above-mentioned problems, which can provide a quantifiable and appropriate force to enable the microneedle to reach a preset delivery position, and has a positive effect on the delivery and release of the drug.

[0005] Technical solution: The utility model provides a controllable flexible pressing device for microneedle patch skin surface drug delivery, including: microneedle patch, electrostatic adsorption film, rigid support body, airbag, thin film pressure sensor, the microneedle patch is attached to the skin surface with the needle facing downward; the electrostatic adsorption film is arranged above the microneedle patch; the rigid support body is arranged on the electrostatic adsorption film, and there is an airbag installation cavity in the middle of the rigid support body; the airbag is arranged in the airbag installation cavity; the thin film pressure sensor covers the airbag. The use of airbags to provide flexible pressure improves the randomness and uncertainty of microneedle patch drug delivery in the past by manual operation.

[0006] Furthermore, in the above-mentioned controllable flexible pressing device for drug delivery on the skin surface of a microneedle patch, the rigid support body can be covered with a high-viscosity tape.

[0007] Furthermore, in the above-mentioned controllable flexible pressing device for administering drug on the skin surface of a microneedle patch, a plurality of compression airbags can be connected to both sides of the airbag.

[0008] Furthermore, in the above-mentioned controllable flexible pressing device for drug delivery on the skin surface of a microneedle patch, an active buckle is provided at the outermost end of the compression airbag.

[0009] Furthermore, in the above-mentioned controllable flexible pressing device for drug delivery on the skin surface of a microneedle patch, the thin film pressure sensor is connected to the pressure display and control integrated device. The thin film pressure sensor is used to convert pressure into an electrical signal and transmit it to the pressure display and control integrated device for displaying and controlling the pressure value or mechanical curve.

[0010] Furthermore, in the above-mentioned controllable flexible pressing device for administering drugs on the skin surface of a microneedle patch, the air bag is provided with evenly or unevenly distributed air paths to ensure that the microneedle patch can be applied to different tissue sites.

[0011] Furthermore, in the above-mentioned controllable flexible pressing device for drug delivery on the skin surface of a microneedle patch, the air bag is connected to an internally integrated or external air pump through an air path.

[0012] It can be seen from the above technical scheme that the utility model has the following beneficial effects: the controllable flexible pressing device for microneedle patch skin surface drug delivery described in the utility model has a simple structure and is easy to operate, and provides a quantifiable controllable pressing means, which improves the randomness and uncertainty of previous manual operation of microneedle patch drug delivery, and provides a new path for non-clinical research, clinical research and final product design of microneedle drug delivery, solves the influence of the direction, rate of change, size and action time of force application during drug delivery, controls the penetration depth of microneedles, and thus has a positive impact on experimental results and clinical effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 This is a schematic diagram of the structure of a controllable flexible pressing device (attachment type) used for drug delivery on the skin surface of a microneedle patch of the utility model;

[0014] Figure 2 The utility model is a schematic structural diagram of a controllable flexible pressing device (binding type) used for drug delivery on the skin surface of a microneedle patch.

[0015] In the figure: microneedle patch 1, electrostatic adsorption membrane 2, rigid support body 3, airbag 4, thin film pressure sensor 5, high viscosity tape 6, compression airbag 7, movable buckle 8, pressure display and control integrated device 9, air pump 10, airbag installation cavity 31. DETAILED DESCRIPTION

[0016] Example 1

[0017] like Figure 1 The controllable flexible pressing device for drug delivery on the skin surface of a microneedle patch shown in the figure comprises: a microneedle patch 1, an electrostatic adsorption film 2, a rigid support 3, an airbag 4, and a thin film pressure sensor 5. The microneedle patch 1 is attached to the skin surface with the needle facing downward; the electrostatic adsorption film 2 is arranged above the microneedle patch 1; the rigid support 3 is arranged on the electrostatic adsorption film 2, and an airbag installation cavity 31 is arranged in the middle of the rigid support 3; the airbag 4 is arranged in the airbag installation cavity 31; and the thin film pressure sensor 5 covers the airbag 4. The use of the airbag 4 to provide flexible pressure improves the randomness and uncertainty of the previous manual operation of drug delivery of the microneedle patch 1.

[0018] In this embodiment, the rigid support body 3 may be covered with a high-viscosity tape 6 .

[0019] In this embodiment, the thin film pressure sensor 5 is connected to the pressure display and control integrated device 9. The thin film pressure sensor 5 is used to convert pressure into an electrical signal and transmit it to the pressure display and control integrated device 9 for displaying and controlling the pressure value or mechanical curve.

[0020] In this embodiment, the microneedle patch 1 can be used to administer drugs on a relatively large and smooth skin surface of an animal or human body, and the device of this embodiment can be reused.

[0021] In this embodiment, a uniformly or unevenly distributed air path is provided in the airbag 4 , and the airbag 4 is connected to an internally integrated or external air pump 10 through the air path.

[0022] Example 2

[0023] On the basis of Example 1, in this example, Figure 2 The shown device is a controllable flexible pressing device for drug delivery on the skin surface of a microneedle patch, comprising a microneedle patch 1, an electrostatic adsorption film 2, a rigid support body 3, an airbag 4, and a thin film pressure sensor 5. The microneedle patch 1 is attached to the skin surface with the needle tip facing downward; the electrostatic adsorption film 2 is arranged above the microneedle patch 1; the rigid support body 3 is arranged on the electrostatic adsorption film 2, and an airbag mounting cavity 31 is provided in the middle of the rigid support body 3; the airbag 4 is arranged in the airbag mounting cavity 31; and the thin film pressure sensor 5 covers the airbag 4.

[0024] In this embodiment, the microneedle patch 1 can be used to administer drugs on the skin surface of the limbs of animals or humans, and the device of this embodiment can be reused.

[0025] In this embodiment, a plurality of compression airbags 7 can be connected to both sides of the airbag 4 , and an active buckle 8 is provided at the outermost end of the compression airbag 7 .

[0026] In this embodiment, the thin film pressure sensor 5 is connected to the pressure display and control integrated device 9 .

[0027] In this embodiment, a uniformly or unevenly distributed air path is provided in the airbag 4 , and the airbag 4 is connected to an internally integrated or external air pump 10 through the air path.

[0028] It should be noted that the above is only a technical solution of the utility model and is not a limitation. Although the utility model is described in detail with reference to the preferred embodiments, a person skilled in the art should understand that the technical solution of the utility model can be modified or replaced by equivalents without departing from the scope of the technical solution of the utility model, which should be included in the scope of the claims of the utility model.

Claims

1. A controllable flexible pressing device for drug delivery on the skin surface of a microneedle patch, characterized in that: include: A microneedle patch (1), wherein the microneedle patch (1) is attached to the skin surface with the needles facing downward; An electrostatic adsorption film (2), wherein the electrostatic adsorption film (2) is arranged above the microneedle patch (1); A rigid support body (3), wherein the rigid support body (3) is arranged on the electrostatic adsorption film (2), and an airbag installation cavity (31) is provided in the middle of the rigid support body (3); An airbag (4), wherein the airbag (4) is arranged in the airbag installation cavity (31); A thin film pressure sensor (5), wherein the thin film pressure sensor (5) covers the air bag (4).

2. A controllable flexible pressing device for microneedle patch skin surface drug delivery according to claim 1, characterized in that: The rigid support body (3) may be covered with a high-viscosity tape (6).

3. A controllable flexible pressing device for microneedle patch skin surface drug delivery according to claim 1, characterized in that: A plurality of compression airbags (7) can be connected to both sides of the airbag (4).

4. A controllable flexible pressing device for microneedle patch skin surface drug delivery according to claim 3, characterized in that: The outermost end of the compression airbag (7) is provided with a movable buckle (8).

5. A controllable flexible pressing device for microneedle patch skin surface drug delivery according to claim 1, characterized in that: The thin film pressure sensor (5) is connected to a pressure display and control integrated device (9).

6. A controllable flexible pressing device for microneedle patch skin surface drug delivery according to claim 1, characterized in that: The air bag (4) is provided with evenly distributed or unevenly distributed air paths.

7. A controllable flexible pressing device for microneedle patch skin surface drug delivery according to claim 6, characterized in that: The air bag (4) is connected to an internally integrated or external air pump (10) via an air path.

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