Preparation device of surface function modified biogel

Abstract

The utility model discloses a preparation device of surface function modified biogel, which belongs to the technical field of biogel preparation and comprises a lower module, and a lower groove is formed in the center of the top surface of the lower module; the upper module and the lower module are buckled with each other, and an upper groove corresponding to the lower groove is formed in the center of the bottom surface of the upper module; a spiral pipeline is arranged in the upper groove and is a planar spiral, two ends of the spiral pipeline are sealed, the center of the top surface is communicated with an injection pipeline, and the injection pipeline is fixedly connected with the upper module, penetrates through the top of the upper module and is communicated with the outside; a plurality of outflow holes are formed in the bottom surface of the spiral pipeline. According to the utility model, the active component can be fixed on the outer surface of the biopolymer material, so that the release of the active component is facilitated, the thermosensitive biopolymer material and the active component are separately added, and when the active component and the thermosensitive biopolymer material are fused, the thermosensitive biopolymer material is in a cooling state, so that the temperature is reduced; influence of high temperature on the active material can be reduced as much as possible, and activity of the active material is maintained.

Description

Technical Field

[0001] The utility model belongs to the technical field of biogel preparation, and particularly relates to a preparation device for a biogel with surface functional modification. Background Art

[0002] Biogel is a polymer material that is similar to natural soft tissue in structure, morphology and function. It is mainly composed of biopolymers, crosslinkers and water. Biogel is widely used in our lives. Its biomedical applications can be divided into the following areas: hydrogels can be used as drug release carriers, ophthalmic materials, tissue engineering scaffolds, medical dressings and cosmetic materials, etc. They use their high water content, biocompatibility, biodegradability, stress responsiveness, water retention and breathability to achieve the fixation and release of cells, drugs, proteins, etc., promote wound healing and skin regeneration, improve the physiological state of the eyes, etc., and are an excellent type of biomaterial.

[0003] Thermosensitive gel is one of the important forms of biogel. Thermosensitive hydrogel is a polymer material that can undergo phase transition from liquid to solid when the temperature changes, so it has good temperature sensitivity. It also has many characteristics of polymer materials, such as network structure and high water content. This material has broad application prospects in the fields of medicine, biotechnology, cosmetics, etc. More importantly, thermosensitive gel can complete liquid-gel transition with the change of temperature. Active ingredients such as peptides, genes, proteins, cells and small molecule drugs can be evenly mixed into the gel solution, so it has broad application prospects in the field of tissue engineering scaffolds. However, these active ingredients often need to be stored at low temperatures, and when making biogel, the gel needs to be heated into a liquid state first, injected into the mold, and then gradually cooled to a solid state for molding. The change in temperature has a great influence on the activity of the active ingredients. And the active ingredients are often added inside the gel, making it difficult for the active ingredients to be released in a short time.

[0004] To this end, a preparation device for a surface functionally modified biogel is proposed to achieve effective mixing of thermosensitive materials and low-temperature active ingredients, and to load the active ingredients on the surface to accelerate the release, so as to prepare high-performance functional biogel. Utility Model Content

[0005] In order to solve the above technical problems, the utility model provides a preparation device for biogel with surface functional modification.

[0006] To achieve the above-mentioned purpose, the utility model provides a device for preparing a surface functionally modified biogel, comprising:

[0007] A lower module, wherein a lower groove is provided at the center of the top surface of the lower module;

[0008] The upper module and the lower module are buckled with each other, and an upper groove is opened at the center of the bottom surface of the upper module corresponding to the lower groove; a spiral pipe is arranged in the upper groove, and the spiral pipe is a plane spiral with sealed ends, and an injection pipe is connected to the center of the top surface, and the injection pipe is fixedly connected to the upper module and passes through the top of the upper module to communicate with the outside world; a plurality of outflow holes are opened on the bottom surface of the spiral pipe.

[0009] Preferably, the bottom surface of the spiral pipe is lower than the bottom surface of the upper module, extends into the top surface of the lower groove, and is higher than the bottom surface of the lower groove.

[0010] Preferably, the maximum diameter of the spiral pipe is smaller than the inner diameters of the upper groove and the lower groove.

[0011] Preferably, a funnel is provided at the top of the injection pipe, and the funnel is embedded in the top surface of the upper module.

[0012] Preferably, handles are fixedly connected to both sides of the upper module.

[0013] Preferably, flanges are fixedly connected to the bottom and top surfaces of the lower module, and recesses are provided around the bottom surface of the upper module corresponding to the flanges.

[0014] Preferably, the outflow holes are evenly opened along the spiral pipe.

[0015] Preferably, an air outlet is provided on the top surface of the upper module.

[0016] Compared with the prior art, the utility model has the following advantages and technical effects:

[0017] When in use, first separate the upper module from the lower module, place the lower module on a stable table, with the lower groove facing upward, inject the temperature-sensitive biopolymer material heated into a liquid state into the lower groove, then buckle the upper module and the lower module, and then inject the active ingredient from the injection pipe into the spiral pipe, and the active ingredient flows into the upper surface of the temperature-sensitive biopolymer material located in the lower groove through the outflow hole at the bottom of the spiral pipe, and the temperature-sensitive biopolymer material is fused with the active ingredient while cooling and solidifying, and finally obtains a biogel with surface functional modification. The active ingredient is fixed on the outer surface of the biopolymer material, which is more conducive to the release of the active ingredient, and the temperature-sensitive biopolymer material is added separately from the active ingredient. When the active ingredient is fused with the temperature-sensitive biopolymer material, the temperature-sensitive biopolymer material is in a cooling state, which can minimize the influence of high temperature on the active material when the temperature-sensitive biopolymer material is heated and melted, and the activity of the active material is maintained as much as possible. And the preparation system of the present invention has a simple process, easy to control reaction, good stability, and can be industrialized, and has a broad promotion prospect. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The drawings constituting a part of the present application are used to provide a further understanding of the present application. The illustrative embodiments and descriptions of the present application are used to explain the present application and do not constitute an improper limitation on the present application. In the drawings:

[0019] Figure 1 This is a schematic diagram of the structure of a preparation device for the surface functionally modified biogel of the utility model;

[0020] Figure 2 This is a schematic structural diagram of the open state of the preparation device of the surface functionally modified biogel of the utility model;

[0021] Figure 3 This is a bottom view of the upper module of the utility model;

[0022] Figure 4 It is a cross-sectional view of the upper module in the utility model.

[0023] In the figure: 1, lower module; 2, lower groove; 3, upper module; 4, upper groove; 5, spiral pipe; 6, injection pipe; 7, outflow hole; 8, funnel; 9, handle; 10, flange; 11, depression; 12, air outlet. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0025] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0026] Reference Figures 1 to 4 As shown, this embodiment provides a preparation device for a surface functionally modified biogel, comprising:

[0027] A lower module 1, wherein a lower groove 2 is provided at the center of the top surface of the lower module 1;

[0028] The upper module 3 and the lower module 1 are buckled with each other, and an upper groove 4 is opened at the center of the bottom surface of the upper module 3 corresponding to the lower groove 2; a spiral pipe 5 is arranged in the upper groove 4, and the spiral pipe 5 is a plane spiral with sealed ends, and an injection pipe 6 is connected to the center of the top surface. The injection pipe 6 is fixedly connected to the upper module 3 and passes through the top of the upper module 3 to communicate with the outside world; a plurality of outflow holes 7 are opened on the bottom surface of the spiral pipe 5.

[0029] When in use, first separate the upper module 3 from the lower module 1, place the lower module 1 on a stable table, with the lower groove 2 facing upward, inject the heated liquid thermosensitive biopolymer material into the lower groove 2, then buckle the upper module 3 and the lower module 1, and then inject the active ingredient from the injection pipe 6 into the spiral pipe 5, and the active ingredient flows into the upper surface of the thermosensitive biopolymer material located in the lower groove 2 through the outflow hole 7 at the bottom of the spiral pipe 5, and the thermosensitive biopolymer material is fused with the active ingredient while cooling and solidifying, and finally obtains a biogel with surface functional modification. The active ingredient is fixed on the outer surface of the biopolymer material, which is more conducive to the release of the active ingredient, and the thermosensitive biopolymer material is added separately from the active ingredient. When the active ingredient is fused with the thermosensitive biopolymer material, the thermosensitive biopolymer material is in a cooling state, which can minimize the influence of high temperature on the active material when the thermosensitive biopolymer material is heated and melted, and the activity of the active material is maintained as much as possible. And the preparation system of the present invention is simple in process, easy to control the reaction, good in stability, industrializable, and has a wide range of promotion prospects.

[0030] Furthermore, the spiral pipe 5, the injection pipe 6 and the funnel 8 are preferably made of silica gel material.

[0031] Furthermore, the thermosensitive biopolymer material is preferably one or more of gelatin, elastin polypeptide, chitosan, methylcellulose, hydroxypropyl methylcellulose, and xyloglucan.

[0032] Furthermore, the active ingredient is preferably one or more of cells, cytokines, cell supernatant, protein solution, polypeptide solution, and exosome solution.

[0033] According to a further optimized solution, the bottom surface of the spiral pipe 5 is lower than the bottom surface of the upper module 3 , extends into the top surface of the lower groove 2 , and is higher than the bottom surface of the lower groove 2 .

[0034] Extending the bottom surface of the spiral pipe 5 into the lower groove 2 allows the active ingredients to be added later. When the active ingredients flow out from the outflow hole 7 on the bottom surface of the spiral pipe 5, they will enter below the upper surface of the temperature-sensitive biopolymer material in the lower groove 2. Compared with directly flowing out above the upper surface and then gradually merging downward, flowing out below the upper surface has a better fusion effect and can also avoid excessive exposure of active ingredients on the outer surface.

[0035] According to a further optimization scheme, the maximum diameter of the spiral pipe 5 is smaller than the inner diameters of the upper groove 4 and the lower groove 2 .

[0036] The spiral pipe 5 should be inside the upper groove 4 and the lower groove 2 and should not exceed the inner cavity range thereof to avoid destroying the shape of the thermosensitive biopolymer gel and avoiding overflow and waste of active materials.

[0037] According to a further optimized solution, a funnel 8 is provided at the top of the injection pipe 6 , and the funnel 8 is embedded in the top surface of the upper module 3 .

[0038] The funnel 8 facilitates the injection of the active ingredient and helps the syringe outlet to align with the injection pipe 6 inlet.

[0039] To further optimize the solution, handles 9 are fixedly connected to both sides of the upper module 3 .

[0040] The handle 9 facilitates the opening of the upper and lower modules 1 .

[0041] According to a further optimized solution, flanges 10 are fixedly connected to the bottom and top surfaces of the lower module 1 , and recesses 11 are provided corresponding to the flanges 10 on the bottom surface of the upper module 3 .

[0042] The flange 10 and the recess 11 cooperate with each other to facilitate the alignment of the upper groove 4 and the lower groove 2 of the mold.

[0043] According to a further optimized solution, the outflow holes 7 are evenly opened along the spiral pipe 5 .

[0044] The outflow holes 7 are evenly arranged, so that the active ingredients can enter the temperature-sensitive biopolymer material as evenly as possible, making the fusion more uniform.

[0045] According to a further optimized solution, an air outlet 12 is provided on the top surface of the upper module 3 .

[0046] The air outlet 12 can discharge the gas in the cavity after the upper groove 4 and the lower groove 2 are buckled together to maintain the balance of internal and external air pressure.

[0047] The parts not described in detail in the present invention are all conventional technical means known to those skilled in the art.

[0048] In the description of the present invention, it should be understood that the terms "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside" and "outside" etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0049] The embodiments described above are only descriptions of the preferred methods of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should fall within the protection scope determined by the claims of the present invention.

Claims

1. A device for preparing a biogel with surface functional modification, characterized in that: include: A lower module (1), wherein a lower groove (2) is provided at the center of the top surface of the lower module (1); An upper module (3), wherein the upper module (3) and the lower module (1) are interlocked, and an upper groove (4) is provided at the center of the bottom surface of the upper module (3) corresponding to the lower groove (2); a spiral pipe (5) is provided in the upper groove (4), and the spiral pipe (5) is a plane spiral with sealed ends, and an injection pipe (6) is connected at the center of the top surface, and the injection pipe (6) is fixedly connected to the upper module (3) and passes through the top of the upper module (3) to communicate with the outside; a plurality of outflow holes (7) are provided on the bottom surface of the spiral pipe (5).

2. The device for preparing the surface functionally modified biogel according to claim 1, characterized in that: The bottom surface of the spiral pipe (5) is lower than the bottom surface of the upper module (3), extends into the top surface of the lower groove (2), and is higher than the bottom surface of the lower groove (2).

3. The device for preparing the surface functionally modified biogel according to claim 1, characterized in that: The maximum diameter of the spiral pipe (5) is smaller than the inner diameters of the upper groove (4) and the lower groove (2).

4. The device for preparing the surface functionally modified biogel according to claim 1, characterized in that: A funnel (8) is provided at the top of the injection pipe (6), and the funnel (8) is embedded in the top surface of the upper module (3).

5. The device for preparing the surface functionally modified biogel according to claim 1, characterized in that: Handles (9) are fixedly connected to both sides of the upper module (3).

6. The device for preparing the surface functionally modified biogel according to claim 1, characterized in that: The bottom and top surfaces of the lower module (1) are fixedly connected with flanges (10) around them, and the bottom surface of the upper module (3) is provided with recesses (11) corresponding to the flanges (10) around them.

7. The device for preparing the surface functionally modified biogel according to claim 1, characterized in that: The outflow holes (7) are evenly arranged along the spiral pipe (5).

8. The device for preparing the surface functionally modified biogel according to claim 1, characterized in that: An air outlet hole (12) is provided on the top surface of the upper module (3).

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