Human body micro-physiological system for simulating three-dimensional anatomical structure

Abstract

The utility model relates to the field of micro-physiological systems, in particular to a human body micro-physiological system simulating a three-dimensional anatomical structure, which comprises a bionic module including a head top cover module, a head and neck module, a heart and lung module, a waist and abdomen module, a forearm module, a hip and leg module and a shank module; the organ chambers are arranged in the bionic module corresponding to a human body structure, and any organ chamber is provided with at least one opening in the surface of the bionic module; the pipeline channel is distributed in the bionic module; when the bionic modules form a bionic whole, the communicated pipeline channels form at least two independent passages, and the passages are communicated with any organ cavity. According to the utility model, a highly-simulated human body structure and functional partitions are provided, the reliability and accuracy of the simulation effect are ensured, the good bionic property is beneficial to more accurately simulating the interaction between human organs and the overall function, and a reliable research and development experiment platform is provided for drug screening and precision medical treatment.

Description

Technical Field

[0001] The utility model relates to the technical field of microphysiological systems, in particular to a human microphysiological system that simulates a three-dimensional anatomical structure. Background Art

[0002] Microphysiological systems with multiple "organs", also known as human chips, provide powerful tools for drug discovery. This technology is able to predict the effects of candidate drugs on the entire human body, not just on a single organ or tissue. In order to accurately replicate the human body, human chips require cells or tissues from the human body. Progress in this area has been rapid, and on April 20, 2023, the China National Medical Products Administration's Drug Review Center approved a cell therapy using NK cells derived from iPSCs, which was an important milestone. However, achieving a comprehensive simulation of the human body through human chips requires more than just the use of human cells or tissues. The three-dimensional nature of the human body and its complex anatomical structure also need to be considered in the design and manufacture of human chips, because it fundamentally determines the communication between organs and organ function.

[0003] For example, the liver's location in the upper abdomen was not chosen randomly but was determined by a variety of factors, including size, function, and complex interactions with neighboring organs. This location facilitates efficient blood processing and filtration as the liver receives nutrient-rich blood from the digestive system via the hepatic portal vein. The liver performs important tasks such as metabolism, detoxification, nutrient storage, and bile production. Its proximity to important structures such as the gallbladder and pancreas further supports digestion and nutrient absorption. The liver is connected to other organs through a complex network of blood vessels, bile ducts, and nerves, enabling seamless communication and coordination with neighboring physiological entities.

[0004] Likewise, the kidney emphasizes the importance of its unique location within the retroperitoneal space in the posterior lumbar region. This deliberate, rather than arbitrarily chosen, positioning is fundamental to its critical role in waste filtration, regulation of water and electrolyte balance, and urine production. Its proximity to major blood vessels, such as the renal artery and vein, optimizes the filtering of blood by the kidneys. In addition, their proximity to the bladder provides a relatively short passage for urine to pass through the ureters.

[0005] The traditional in vitro model for simulating the human body is the human chip. However, the current human chips are still two-dimensional and fail to take into account the three-dimensional anatomical structure of the human body, which is the key to shaping the interaction and function of organs. The two-dimensional human chip ignores the impact caused by the fixed three-dimensional position of each organ in the human body, making it difficult to faithfully simulate the complexity and overall function of the human body. Utility Model Content

[0006] Therefore, the technical problem to be solved by the present invention is to overcome the problem in the prior art of lacking an in vitro model simulating the human body based on a three-dimensional anatomical structure.

[0007] In order to solve the above technical problems, the utility model provides a human microphysiological system simulating a three-dimensional anatomical structure, comprising:

[0008] The bionic module comprises a head cover module, a head and neck module, a cardiopulmonary module, a waist and abdomen module, a forearm module, a hip and leg module, and a calf module; wherein the head cover module and the head and neck module, the cardiopulmonary module and the head and neck module, the forearm module and the cardiopulmonary module, the waist and abdomen module and the cardiopulmonary module, the hip and leg module and the waist and abdomen module, and the calf module and the hip and leg module can be detachably connected; when all the bionic modules are in a connected state, a bionic whole is formed;

[0009] An organ chamber is arranged in the bionic module corresponding to the human body structure, and any of the organ chambers is provided with at least one opening on the surface of the bionic module;

[0010] The pipeline channels are distributed in the bionic module; when the bionic module constitutes a bionic whole, the pipeline channels between the head cover module and the head and neck module, between the cardiopulmonary module and the head and neck module, between the forearm module and the cardiopulmonary module, between the waist and abdomen module and the cardiopulmonary module, between the hip and leg module and the waist and abdomen module, and between the calf module and the hip and leg module are all connected, and the connected pipeline channels form at least two independent passages, which are connected to any of the organ chambers.

[0011] In one embodiment of the utility model, two forearm modules are provided, one of which is provided with a first forearm upward channel, the first forearm upward channel is provided with a first liquid inlet, and the other forearm module is provided with a second forearm upward channel, the second forearm upward channel is provided with a second liquid inlet; two calf modules are provided, one of which is provided with a first calf descending channel and a second calf descending channel, the first calf descending channel is provided with a first liquid outlet, the second calf descending channel is provided with a second liquid outlet, and the other calf module is provided with a third calf descending channel and a fourth calf descending channel, the third calf descending channel is provided with a third liquid outlet, and the fourth calf descending channel is provided with a fourth liquid outlet.

[0012] In one embodiment of the utility model, the cardiopulmonary module is provided with a first cardiopulmonary ascending channel, a second cardiopulmonary ascending channel, a first cardiopulmonary descending channel and a second cardiopulmonary descending channel, the first cardiopulmonary ascending channel is connected to the first forearm ascending channel, the second cardiopulmonary ascending channel is connected to the second forearm ascending channel; the cardiopulmonary module is also provided with at least three organ chambers opening upward.

[0013] In one embodiment of the utility model, a first lumbar and abdominal descending channel and a second lumbar and abdominal descending channel are provided in the lumbar and abdominal module, the first lumbar and abdominal descending channel is connected to the first heart and lung descending channel, and the second lumbar and abdominal descending channel is connected to the second heart and lung descending channel; at least two organ chambers opening upward are provided in the lumbar and abdominal module.

[0014] In one embodiment of the utility model, a first hip-leg descending channel and a second hip-leg descending channel are provided in the hip-leg module, the upper end of the first hip-leg descending channel is connected with the first waist-abdomen descending channel, the lower end of the first hip-leg descending channel is branched into two first branches, one of which is connected with the first calf descending channel, and the other first branch is connected with the third calf descending channel; the upper end of the second hip-leg descending channel is connected with the second waist-abdomen descending channel, the lower end of the second hip-leg descending channel is branched into two second branches, one of which is connected with the second calf descending channel, and the other second branch is connected with the fourth calf descending channel; at least two organ chambers opening upward are provided in the hip-leg module.

[0015] In one embodiment of the utility model, the head and neck module is provided with a first head and neck ascending channel, a second head and neck ascending channel, a first head and neck descending channel and a second head and neck descending channel; the first head and neck ascending channel is connected with the first heart and lung ascending channel, the second head and neck ascending channel is connected with the second heart and lung ascending channel, the first head and neck descending channel is connected with the first heart and lung descending channel, and the second head and neck descending channel is connected with the second heart and lung descending channel; at least one organ chamber opening upward is provided in the head and neck module.

[0016] In one embodiment of the utility model, a first top cover channel and a second top cover channel are provided in the top cover module, and the two ends of the first top cover channel are respectively connected to the first head and neck ascending channel and the first head and neck descending channel, and the two ends of the second top cover channel are respectively connected to the second head and neck descending channel and the second head and neck descending channel.

[0017] In one embodiment of the utility model, when the bionic modules constitute a bionic whole, the pipeline channel in the head cover module is connected to the organ chamber in the head and neck module, the pipeline channel in the head and neck module is connected to the organ chamber in the heart and lung module, the pipeline channel in the heart and lung module is connected to the organ chamber in the waist and abdomen module, and the pipeline channel in the waist and abdomen module is connected to the organ chamber in the hip and leg modules.

[0018] In one embodiment of the utility model, a blood-brain barrier is further provided between the pipeline channel in the top head cover module and the organ chamber in the head and neck module; the liquid in the organ chamber in the head and neck module exchanges substances with the liquid in the pipeline channel in the top head cover module through the blood-brain barrier.

[0019] In one embodiment of the present invention, the organ chambers include brain culture chambers, eye culture chambers, nasal culture chambers, ear culture chambers, tongue culture chambers, tracheal culture chambers, heart culture chambers, lung culture chambers, liver-intestine culture chambers, kidney culture chambers, stomach culture chambers, pancreas culture chambers, spleen culture chambers, skin culture chambers, fat culture chambers, bone marrow culture chambers, muscle culture chambers, testicular culture chambers and tumor culture chambers.

[0020] The above technical solution of the utility model has the following beneficial effects compared with the prior art:

[0021] First of all, the human microphysiological system that simulates three-dimensional anatomical structure provided by the utility model has a highly simulated human structure and functional divisions. Through the reasonable combination of bionic modules, organ chambers, and pipeline channels, the reliability and accuracy of the simulation effect are ensured. Good bionics helps to more accurately simulate the interactions and overall functions between human organs, providing a reliable R&D experimental platform for drug screening and precision medicine.

[0022] Secondly, at least two independent passages are set up in the utility model, and the organ chambers in each bionic module are connected by pipeline channels, so as to realize the independent classification supply of different body fluids, enable the physiological fluids in the system to flow according to different passages, and simulate the distribution and function of the human blood, lymph and other channel systems, which provides convenience and accuracy for studying the interaction between different organs and the influence of drugs on the whole human body. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to make the content of the utility model easier to understand, the utility model is further described in detail according to the specific embodiments of the utility model in combination with the accompanying drawings, wherein

[0024] Figure 1 It is a structural framework diagram of the human body's microphysiological system.

[0025] Figure 2 It is a schematic diagram of the flow of pathways in the human microphysiological system;

[0026] Figure 3 A is a schematic diagram of the structure of the two-dimensional human chip used as a control in Example 2; B is a comparison of the vitality of five primary tissues co-cultured in a human microphysiological system (three-dimensional human chip), co-cultured in a two-dimensional human chip, and cultured alone.

[0027] Explanation of the reference numerals in the specification: 20, top cover module; 21, first top cover channel; 22, second top cover channel; 30, head and neck module; 31, first head and neck ascending channel; 32, second head and neck ascending channel; 33, first head and neck descending channel; 34, second head and neck descending channel; 40, cardiopulmonary module; 41, first cardiopulmonary ascending channel; 42, second cardiopulmonary ascending channel; 43, first cardiopulmonary descending channel; 44, second cardiopulmonary descending channel; 50, waist and abdomen module; 51, first waist and abdomen descending channel; 52, second waist and abdomen descending channel; 60, forearm module; 61, first forearm ascending channel; 62, second forearm ascending channel; 70, hip and leg module; 71, first hip and leg descending channel; 72, second hip and leg descending channel; 80, calf module; 81, first calf descending channel; 82, second calf descending channel; 83, third calf descending channel; 84, fourth calf descending channel. DETAILED DESCRIPTION

[0028] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments so that those skilled in the art can better understand the present invention and implement it, but the embodiments are not intended to limit the present invention.

[0029] Embodiment 1

[0030] Reference Figure 1-2 As shown, the utility model provides a human microphysiological system simulating a three-dimensional anatomical structure, comprising:

[0031] The bionic module includes a head cover module 20, a head and neck module 30, a cardiopulmonary module 40, a waist and abdomen module 50, a forearm module 60, a hip and leg module 70, and a calf module 80; wherein the head cover module 20 and the head and neck module 30, the cardiopulmonary module 40 and the head and neck module 30, the forearm module 60 and the cardiopulmonary module 40, the waist and abdomen module 50 and the cardiopulmonary module 40, the hip and leg module 70 and the waist and abdomen module 50, and the calf module 80 and the hip and leg module 70 can be detachably connected; when all the bionic modules are in a connected state, a bionic whole is formed;

[0032] An organ chamber is arranged in the bionic module corresponding to the human body structure, and any of the organ chambers is provided with at least one opening on the surface of the bionic module;

[0033] The pipeline channels are distributed in the bionic module; when the bionic module constitutes a bionic whole, the pipeline channels between the head cover module 20 and the head and neck module 30, between the cardiopulmonary module 40 and the head and neck module 30, between the forearm module 60 and the cardiopulmonary module 40, between the waist and abdomen module 50 and the cardiopulmonary module 40, between the hip and leg module 70 and the waist and abdomen module 50, and between the calf module 80 and the hip and leg module 70 are all connected, and the connected pipeline channels form at least two independent passages, which are connected to any of the organ chambers.

[0034] Specifically, the bionic modules designed and manufactured according to the human anatomical structure have a high similarity to the human body in appearance after being assembled into one, wherein each bionic module is divided according to the corresponding functional area of ​​the human body, and each bionic module should conform to the shape and size of the human body contour as much as possible to ensure a good simulation effect; in some embodiments, the bionic modules are connected by detachable means such as snaps, threads, magnetism, bonding, etc., to ensure a firm connection and easy disassembly between the bionic modules, so as to facilitate repeated use and maintenance in experiments; organ chambers and pipeline channels are provided inside some or all of the bionic modules, wherein the organ chambers should also be arranged in each bionic module according to the three-dimensional anatomical position of the human organs in the body, and the shape of the organ chambers should also be consistent with the corresponding organs. The appearance and shape are similar; on the other hand, the organ chamber is also provided with at least one opening on the surface of the bionic module to facilitate material exchange and detection with the external environment / pathway. Specifically, when each bionic module is in a disassembled state, the operator can supplement or detect the material in the organ chamber through the opening. When the bionic modules are assembled into a bionic whole, the opening is closed inside the bionic whole and can exchange materials with the liquid in the pathway through the corresponding pipeline channels. The layout of the pipeline channels is used to simulate the distribution of channel systems such as human blood vessels and lymphatic vessels. When the bionic modules are assembled into a bionic whole, the pipeline channels between the modules are interconnected, and at least two independent pathways are formed through the distribution of the pipeline channels to facilitate the system to realize independent classification supply of different body fluids.

[0035] In some embodiments, the two pathways in the bionic whole form two end-to-end loop networks; in other specific embodiments, referring to Figure 1-2As shown, the forearm module 60 serves as the total liquid inlet of the passage, and the calf module 80 serves as the total liquid outlet of the passage, thereby forming two one-way flow passages (or forming an external circulation outside the body of the simulated whole). At this time, a pressure control and body fluid supply device can be connected to the outside of the forearm module 60 and / or the calf module 80 to ensure the precise supply and control of the liquid in the passage. Specifically, there are two forearm modules 60, one of which is provided with a first forearm ascending channel 61, the first forearm ascending channel 61 is provided with a first liquid inlet, and the other forearm module 60 is provided with a second forearm ascending channel 62, the second forearm ascending channel 62 is provided with a second liquid inlet; there are two calf modules 80, one of which is provided with a first calf descending channel 81 and a second calf descending channel 82, the first calf descending channel 81 is provided with a first liquid outlet, the second calf descending channel 82 is provided with a second liquid outlet, and the other calf module 80 is provided with a third calf descending channel 83 and a fourth calf descending channel 84, the third calf descending channel 83 is provided with a third liquid outlet, and the fourth calf descending channel 84 is provided with a fourth liquid outlet. The two forearm modules 60 serve as the starting points of the two passages, and the two calf modules 80 serve as the end points of the two passages.

[0036] Further, refer to Figure 1-2 As shown, the cardiopulmonary module 40 is provided with a first cardiopulmonary ascending channel 41, a second cardiopulmonary ascending channel 42, a first cardiopulmonary descending channel 43 and a second cardiopulmonary descending channel 44. The first cardiopulmonary ascending channel 41 is connected to the first forearm ascending channel 61, and the second cardiopulmonary ascending channel 42 is connected to the second forearm ascending channel 62. The cardiopulmonary module 40 is also provided with at least three organ chambers opening upward. The organ chambers in the cardiopulmonary module 40 generally include a heart culture chamber and two lung culture chambers.

[0037] In cardiopulmonary module 40 and below, refer to Figure 1-2As shown, the waist and abdomen module 50 is provided with a first waist and abdomen descending channel 51 and a second waist and abdomen descending channel 52, the first waist and abdomen descending channel 51 is connected with the first heart and lung descending channel 43, and the second waist and abdomen descending channel 52 is connected with the second heart and lung descending channel 44; the waist and abdomen module 50 is provided with at least two organ chambers opening upward. The hip-leg module 70 is provided with a first hip-leg descending channel 71 and a second hip-leg descending channel 72. The upper end of the first hip-leg descending channel 71 is connected to the first waist-abdomen descending channel 51, and the lower end of the first hip-leg descending channel 71 is bifurcated into two first branches, one of which is connected to the first calf descending channel 81, and the other first branch is connected to the third calf descending channel 83; the upper end of the second hip-leg descending channel 72 is connected to the second waist-abdomen descending channel 52, and the lower end of the second hip-leg descending channel 72 is bifurcated into two second branches, one of which is connected to the second calf descending channel 82, and the other second branch is connected to the fourth calf descending channel 84; at least two organ chambers opening upward are provided in the hip-leg module 70. The organ chambers in the waist-abdomen module 50 generally include a liver-intestine culture chamber and a stomach culture chamber, and the organ chambers in the hip-leg module 70 generally include two kidney culture chambers.

[0038] For cardiopulmonary modules above 40, refer to Figure 1-2 As shown, the head and neck module 30 is provided with a first head and neck ascending channel 31, a second head and neck ascending channel 32, a first head and neck descending channel 33 and a second head and neck descending channel 34; the first head and neck ascending channel 31 is connected to the first heart and lung ascending channel 41, the second head and neck ascending channel 32 is connected to the second heart and lung ascending channel 42, the first head and neck descending channel 33 is connected to the first heart and lung descending channel 43, and the second head and neck descending channel 34 is connected to the second heart and lung descending channel 44; at least one organ chamber opening upward is provided in the head and neck module 30. The organ chamber in the head and neck module 30 generally includes a brain culture chamber. The head top cover module 20 is provided with a first head top cover channel 21 and a second head top cover channel 22, the two ends of the first head top cover channel 21 are respectively connected to the first head and neck ascending channel 31 and the first head and neck descending channel 33, and the two ends of the second head top cover channel 22 are respectively connected to the second head and neck descending channel 34 and the second head and neck descending channel 34.

[0039] In some embodiments, the organ chamber in the bionic module is connected to the pipeline channel in the same bionic module to achieve material exchange between the organ chamber and the channel; in other specific embodiments, Figure 2As shown, when the bionic modules form a bionic whole, the pipeline channel in the head top cover module 20 is connected to the organ chamber in the head and neck module 30, the pipeline channel in the head and neck module 30 is connected to the organ chamber in the heart and lung module 40, the pipeline channel in the heart and lung module 40 is connected to the organ chamber in the waist and abdomen module 50, and the pipeline channel in the waist and abdomen module 50 is connected to the organ chamber in the hip and leg module 70. Specifically, taking the head and neck module 30 as an example (other modules are similar and will not be repeated), the first head and neck descending channel 33 and the second head and neck descending channel 34 in the head and neck module 30 both flow through the lower surface of the head and neck module 30, and the pipelines of the two channels close to the lower surface are partially open downward, so that when the head and neck module 30 is connected to the heart and lung module 40, the liquid in the organ chamber in the heart and lung module 40 can exchange substances with the liquid flowing through the first head and neck descending channel 33 and the second head and neck descending channel 34.

[0040] In some specific embodiments, a blood-brain barrier is further provided between the pipeline channel in the top head cover module 20 and the organ chamber in the head and neck module 30; when the liquid in the first top head cover channel 21 and the second top head cover channel 22 flows, the liquid sweeps over the upper surface of the blood-brain barrier, and the lower surface of the blood-brain barrier contacts the liquid in the organ chamber of the head and neck module 30, so that the liquid in the organ chamber in the head and neck module 30 exchanges substances with the liquid in the above-mentioned pipeline channel in the top head cover module 20 through the blood-brain barrier; in a specific embodiment, the blood-brain barrier adopts a blood-brain barrier based on a porous membrane.

[0041] In certain specific embodiments, the organ chambers include brain culture chambers, eye culture chambers, nasal culture chambers, ear culture chambers, tongue culture chambers, tracheal culture chambers, heart culture chambers, lung culture chambers, liver-intestine culture chambers, kidney culture chambers, stomach culture chambers, pancreas culture chambers, spleen culture chambers, skin culture chambers, fat culture chambers, bone marrow culture chambers, muscle culture chambers, testis culture chambers, and tumor culture chambers.

[0042] Example 2: Characterization of three-dimensional human microphysiological system

[0043] In order to characterize the effects of co-culture of various organs in the three-dimensional human body, more sensitive primary mouse tissues were used in this example, including brain, heart, kidney, lung and liver. The activity of primary mouse tissues in the three-dimensional human microphysiological system after 15 days of co-culture, in the two-dimensional human chip after 15 days of co-culture, and in single culture after 15 days was measured. It was found that after 15 days of co-culture, the activity of primary mouse tissues in the three-dimensional human microphysiological system was greater than that in the two-dimensional human chip co-culture, and greater than that in single culture; Figure 3 As shown in A, a two-dimensional human chip as a control is shown, which is manufactured in accordance with Chinese invention patent CN202211518830.4; Figure 3 Figure B shows that the three-dimensional human microphysiological system has a better co-culture effect, can maintain tissue vitality with high fidelity, has high biomimetic properties, and is suitable for multi-disease research.

[0044] Obviously, the above embodiments are merely examples for the purpose of clear explanation and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived from these are still within the scope of protection of the invention of the utility model.

Claims

1. A human microphysiological system simulating a three-dimensional anatomical structure, characterized in that: include: The bionic module comprises a head cover module, a head and neck module, a cardiopulmonary module, a waist and abdomen module, a forearm module, a hip and leg module, and a calf module; wherein the head cover module and the head and neck module, the cardiopulmonary module and the head and neck module, the forearm module and the cardiopulmonary module, the waist and abdomen module and the cardiopulmonary module, the hip and leg module and the waist and abdomen module, and the calf module and the hip and leg module can be detachably connected; when all the bionic modules are in a connected state, a bionic whole is formed; An organ chamber is arranged in the bionic module corresponding to the human body structure, and any of the organ chambers is provided with at least one opening on the surface of the bionic module; The pipeline channels are distributed in the bionic module; when the bionic module constitutes a bionic whole, the pipeline channels between the head cover module and the head and neck module, between the cardiopulmonary module and the head and neck module, between the forearm module and the cardiopulmonary module, between the waist and abdomen module and the cardiopulmonary module, between the hip and leg module and the waist and abdomen module, and between the calf module and the hip and leg module are all connected, and the connected pipeline channels form at least two independent passages, which are connected to any of the organ chambers.

2. A human microphysiological system for simulating three-dimensional anatomical structure according to claim 1, characterized in that: The forearm modules are provided with two, one of which is provided with a first forearm upward channel, the first forearm upward channel is provided with a first liquid inlet, the other forearm module is provided with a second forearm upward channel, the second forearm upward channel is provided with a second liquid inlet; the calf modules are provided with two, one of which is provided with a first calf downward channel and a second calf downward channel, the first calf downward channel is provided with a first liquid outlet, the second calf downward channel is provided with a second liquid outlet, the other calf module is provided with a third calf downward channel and a fourth calf downward channel, the third calf downward channel is provided with a third liquid outlet, the fourth calf downward channel is provided with a fourth liquid outlet.

3. A human microphysiological system for simulating three-dimensional anatomical structure according to claim 2, characterized in that: The cardiopulmonary module is provided with a first cardiopulmonary ascending channel, a second cardiopulmonary ascending channel, a first cardiopulmonary descending channel and a second cardiopulmonary descending channel. The first cardiopulmonary ascending channel is connected to the first forearm ascending channel, and the second cardiopulmonary ascending channel is connected to the second forearm ascending channel. The cardiopulmonary module is also provided with at least three organ chambers opening upward.

4. A human microphysiological system for simulating three-dimensional anatomical structure according to claim 3, characterized in that: The waist and abdomen module is provided with a first waist and abdomen descending channel and a second waist and abdomen descending channel, the first waist and abdomen descending channel is connected with the first heart and lung descending channel, and the second waist and abdomen descending channel is connected with the second heart and lung descending channel; the waist and abdomen module is provided with at least two organ chambers opening upward.

5. The human microphysiological system for simulating three-dimensional anatomical structure according to claim 4, characterized in that: The hip-leg module is provided with a first hip-leg descending channel and a second hip-leg descending channel, the upper end of the first hip-leg descending channel is connected with the first waist-abdomen descending channel, the lower end of the first hip-leg descending channel is bifurcated into two first branches, one of which is connected with the first calf descending channel, and the other first branch is connected with the third calf descending channel; the upper end of the second hip-leg descending channel is connected with the second waist-abdomen descending channel, the lower end of the second hip-leg descending channel is bifurcated into two second branches, one of which is connected with the second calf descending channel, and the other second branch is connected with the fourth calf descending channel; at least two organ chambers opening upward are provided in the hip-leg module.

6. The human microphysiological system for simulating three-dimensional anatomical structure according to claim 3, characterized in that: The head and neck module is provided with a first head and neck ascending channel, a second head and neck ascending channel, a first head and neck descending channel and a second head and neck descending channel; the first head and neck ascending channel is connected with the first heart and lung ascending channel, the second head and neck ascending channel is connected with the second heart and lung ascending channel, the first head and neck descending channel is connected with the first heart and lung descending channel, and the second head and neck descending channel is connected with the second heart and lung descending channel; at least one organ chamber opening upward is provided in the head and neck module.

7. A human microphysiological system for simulating three-dimensional anatomical structure according to claim 6, characterized in that: The top head cover module is provided with a first top head cover channel and a second top head cover channel, the two ends of the first top head cover channel are respectively connected to the first head and neck ascending channel and the first head and neck descending channel, and the two ends of the second top head cover channel are respectively connected to the second head and neck descending channel and the second head and neck descending channel.

8. The human microphysiological system for simulating three-dimensional anatomical structure according to claim 1, characterized in that: When the bionic modules form a bionic whole, the pipeline channel in the head cover module is connected to the organ chamber in the head and neck module, the pipeline channel in the head and neck module is connected to the organ chamber in the heart and lung module, the pipeline channel in the heart and lung module is connected to the organ chamber in the waist and abdomen module, and the pipeline channel in the waist and abdomen module is connected to the organ chamber in the hip and leg modules.

9. The human microphysiological system for simulating three-dimensional anatomical structure according to claim 8, characterized in that: A blood-brain barrier is also provided between the pipeline channel in the top head cover module and the organ chamber in the head and neck module; the liquid in the organ chamber in the head and neck module exchanges substances with the liquid in the pipeline channel in the top head cover module through the blood-brain barrier.

10. The human microphysiological system for simulating three-dimensional anatomical structure according to claim 1, characterized in that: The organ chambers include brain culture chambers, eye culture chambers, nose culture chambers, ear culture chambers, tongue culture chambers, trachea culture chambers, heart culture chambers, lung culture chambers, liver-intestine culture chambers, kidney culture chambers, stomach culture chambers, pancreas culture chambers, spleen culture chambers, skin culture chambers, fat culture chambers, bone marrow culture chambers, muscle culture chambers, testicle culture chambers and tumor culture chambers.

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