Kit positioning assembly, corresponding automatic positioning device, purification equipment and system

Abstract

The utility model provides a kit positioning assembly which comprises a driving positioning module and at least one linkage positioning module driven by the driving positioning module, and the driving positioning module and the linkage positioning module jointly fix and limit a kit. The driving and positioning module comprises a main positioning plate for fixing the first side edge of the kit and a driving piece, and the movable end part of the driving piece is connected with the main positioning plate; the linkage positioning module is provided with a side pushing positioning plate for fixing the second side edge of the kit; when the movable end drives the main positioning plate to be far away from or close to the base in the Y-axis direction, the main positioning plate drives the side pushing positioning plate to be correspondingly far away from or close to the base in the X-axis direction. The utility model further provides a corresponding automatic positioning device, purification equipment and a system. The utility model can solve the problems that the kit is inconvenient to put in and carry out, cannot be matched with an automatic carrying assembly to work, is not firm to fix, has higher requirement on the size of the kit, has strict assembly requirement and the like.

Description

Technical Field

[0001] The utility model relates to the field of reagent box positioning of purification equipment, in particular to a reagent box positioning component of purification equipment, a corresponding automatic positioning device, purification equipment and a system. Background Art

[0002] Existing magnetic bead purification equipment often uses a shrapnel or marble structure to clamp the reagent kit to complete positioning, which has the following problems:

[0003] (1) When inserting the reagent box, it is required to press down to overcome the elastic force of the marble, which requires manual operation and is not suitable for automatic insertion and positioning solutions;

[0004] (2) When working with the fully automatic handling component, the elastic force of the shrapnel or the top bead is too large, and the manipulator encounters a large resistance when placing or grabbing the reagent kit, which can easily lead to the failure of the placement or grabbing operation and affect subsequent experiments;

[0005] (3) In actual use, the reagent kit is not firmly positioned, and the reagent kit is lifted up and down during the purification and extraction process, causing experimental interference;

[0006] (4) The size requirements for the reagent kit, spring piece or marble structure are high. When there is a size error in the assembly, it is difficult for the reagent kit to complete normal positioning.

[0007] Therefore, there is an urgent need to solve the above-mentioned technical problems. Utility Model Content

[0008] The technical problem to be solved by the present invention is to provide a reagent box positioning component, which can solve the problems of inconvenience in placing and taking out the reagent box, the inability to work in a more automated way of loading the reagent box, the weak fixation of the reagent box, high requirements on the size of the reagent box, spring piece or marble structure, and strict assembly requirements.

[0009] In order to solve the above technical problems, the utility model provides a test kit positioning assembly for fixing the test kit placed on a base, including: a driving positioning module and at least one linkage positioning module driven by the driving positioning module, the driving positioning module and the linkage positioning module jointly fix and limit the test kit, wherein the driving positioning module includes: a main positioning plate for fixing the first side edge of the test kit and a driving member capable of driving the main positioning plate, the movable end of the driving member is connected to the main positioning plate, and the main positioning plate is located above the base; the linkage positioning module has a side-push positioning plate for fixing any one of the two adjacent second sides of the first side edge; when the movable end drives the main positioning plate away from or close to the base in the Y-axis direction, the main positioning plate drives the side-push positioning plate to correspondingly move away from or close to the base in the X-axis direction.

[0010] In one embodiment, the linkage positioning module also includes: a connecting member, which is connected to the main positioning plate and moves away from or closer to the base in the Y-axis direction along with the main positioning plate, wherein, in the process of the connecting member moving away from or closer to the base in the Y-axis direction along with the main positioning plate, it drives the side-push positioning plate to move linearly in the X-axis direction.

[0011] In another embodiment, the connecting member is detachably connected to the main positioning plate; and / or the fixed position between the connecting member and the main positioning plate is adjustable in the X-axis direction; further, a plurality of connecting holes are arranged in parallel on the connecting member for screws to pass through and fix to adjust the fixed position, and further, the main positioning plate is provided with a connecting groove for the connecting member to connect, and the fixed position is in the connecting groove.

[0012] In another embodiment, the linkage positioning module also includes: a side-push positioning plate fixing module, the side-push positioning plate fixing module having a guide groove arranged parallel to the base in the X-axis direction, and the side-push positioning plate is guided by the guide groove so that the side-push positioning plate is guided to move linearly in the direction of the X-axis.

[0013] In another embodiment, the side push positioning plate fixing module has two guide grooves symmetrically arranged on both sides of the side push positioning plate.

[0014] In another embodiment, the linkage positioning module further includes: a linkage member, one end of the linkage member is fixed to the side push positioning plate, the connecting member is arranged parallel to the base in the X-axis direction, and has a 90-degree bend in the Y-axis direction, and the side push positioning plate is driven to move linearly in the X-axis direction through the bend, and the bend forms a bending portion in the Y-axis direction, and the bending portion is provided with a movable groove for the other end of the linkage member to move, and the movable groove has an angle with the X-axis direction. Further, the movable grooves are arranged in parallel in multiples, and / or the linkage member is arranged in multiples corresponding to the movable grooves; further, the bend is a rounded bend.

[0015] In another embodiment, a follower bearing is sleeved on the outer periphery of the linkage member, and the follower bearing is arranged in the movable groove.

[0016] In another embodiment, the side of the main positioning plate in contact with the first side is a first abutting portion, and the first abutting portion is provided with a recessed first positioning step for positioning the protruding extension portion at the bottom of the first side.

[0017] In another embodiment, the side of the side-push positioning plate that contacts the second side is a second abutting portion, and the second abutting portion is provided with an inward-recessed second positioning step for positioning the bottom extension of the second side; further, the second abutting portion is also provided with a marble hole located above the second positioning step for loading marbles, which is used to limit the marbles on the second side; further, the marble holes are multiple and arranged in parallel.

[0018] In another embodiment, the reagent box positioning assembly has two linkage positioning modules, and the two linkage positioning modules share one main positioning plate and the driving member.

[0019] In another embodiment, the reagent cartridge positioning assembly further comprises the base, and the driving member is disposed below the base.

[0020] In another embodiment, the base is provided with a reagent box placement block; further, the reagent box placement block is provided with a transverse baffle for fixing the opposite side of the first side of the reagent box in the X-axis direction, and the reagent box placement block is provided with a longitudinal baffle for fixing the opposite side of the second side of the reagent box in the Y-axis direction.

[0021] In another embodiment, the base is provided with two reagent box placement blocks, and further, the two reagent boxes are placed side by side and share one longitudinal blocking bar.

[0022] In another embodiment, the test kit positioning assembly also includes a support module for fixedly supporting the base. Further, the support module has at least two symmetrically arranged support blocks. Further, the support block also has a supporting portion, and the supporting portion is an inverted "Z" shape. The supporting portion is arranged on the outside of the supporting block, and the top of the supporting portion is used to fix the side push positioning plate fixing module. Further, the top of the supporting portion is at the same height as the base.

[0023] The present invention also provides an automatic positioning device for a reagent box, which has a reagent box positioning component and a control module as described in the above technical solution. The control module communicates with the driving member to control the driving member to move away from or approach the base.

[0024] In one embodiment, the control module further includes a driving member activity detection member, which is provided on the driving member for detecting the moving position of the movable end and transmitting the position information of the movable end to the outside.

[0025] The present invention also provides a purification device having a reagent kit positioning component according to the aforementioned technical solution or an automated positioning device according to the aforementioned technical solution. Furthermore, the purification device further comprises any one or more of the following:

[0026] (1) A magnetic rod assembly, including a magnetic rod holder for mounting the magnetic rod;

[0027] (2) a magnetic rod sleeve assembly, comprising a magnetic rod sleeve frame for mounting the magnetic rod sleeve, wherein the magnetic rod sleeve frame is located below the magnetic rod frame, and each of the magnetic rods can be correspondingly inserted into the corresponding magnetic rod sleeve;

[0028] (3) a studio for arranging the magnetic rod assembly, the magnetic rod sleeve assembly, and a placement assembly, wherein the placement assembly includes a reagent box placement block;

[0029] (4) a moving mechanism for driving the magnetic rod sleeve and / or the magnetic rod holder to move vertically and / or horizontally, wherein the moving mechanism includes a horizontal moving mechanism and a vertical moving mechanism, and further, the moving mechanism includes a horizontal moving mechanism for driving the magnetic rod assembly and the magnetic rod sleeve assembly to move horizontally, and a first vertical moving mechanism for driving the magnetic rod assembly to move vertically and a second vertical moving mechanism for driving the magnetic rod sleeve assembly to move vertically;

[0030] (5) a circuit structure, including a circuit structure integrated board for controlling the purification equipment to perform purification operations;

[0031] (6) a heat dissipation device for dissipating heat from the working chamber;

[0032] (7) a disinfection device for disinfecting the working room;

[0033] (8) Any one or more of (1)-(7) are arranged on the base.

[0034] The present invention also provides a purification system having the purification equipment and the transport component according to the above technical solution, wherein the control module communicates with the transport component to control the transport component to transport the reagent kit.

[0035] The beneficial effects of the utility model are as follows:

[0036] (1) The reagent box can be automatically placed by the supporting transport component, and can also be placed manually; after the reagent box is processed, it can be automatically positioned and can be automatically moved out by the supporting transport component, and can also be taken out manually;

[0037] (2) There is no need to press down when inserting the reagent box, as the reagent box can be automatically positioned after being inserted;

[0038] (3) Adjacent test kits share the same main positioning plate and drive member, and the drive member can simultaneously complete the positioning of two adjacent test kits;

[0039] (4) The reagent kit is firmly fixed after positioning, and the reagent kit does not move or even get lifted during the purification process;

[0040] (5) The positioning component of the present invention has lower requirements on the external dimensions of the test kit, and can be used even when there are certain size differences. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] In order to more clearly illustrate the technical solution of the present invention, the following is a brief introduction to the drawings required for the present invention. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0042] Figure 1 This is a schematic diagram of the non-positioning state of the utility model, that is, the movable end of the driving member drives the main positioning plate away from the base along the Y-axis direction and the side push positioning plate away from the base along the X-axis direction;

[0043] Figure 2 This is a schematic diagram of the drive positioning module of the utility model;

[0044] Figure 3 This is a schematic diagram of the drive positioning module of the utility model from another perspective;

[0045] Figure 4 This is an exploded schematic diagram of the linkage positioning module of the present utility model;

[0046] Figure 5 This is a schematic diagram of the assembly of the linkage positioning module of the utility model;

[0047] Figure 6 This is a schematic diagram of the linkage positioning module of the present utility model from another perspective;

[0048] Figure 7 It is a schematic diagram of the side push positioning plate of the utility model;

[0049] Figure 8 This is a schematic diagram of the positioning state of the utility model, that is, the movable end of the driving member drives the main positioning plate to approach the base along the Y-axis direction and the side push positioning plate to approach the base along the X-axis direction;

[0050] Figure 9 It is a schematic diagram of the positioning relationship between the reagent box and the utility model in the positioning state;

[0051] Figure 10 This is a schematic diagram of the positioning relationship between the reagent box and the utility model in the positioning state from another perspective;

[0052] Figure 11 It is a schematic diagram of the internal assembly of the purification equipment of the present invention.

[0053] Among them, the figure marks in the figure are: 1. base; 11. horizontal baffle; 12. longitudinal baffle; 2. support block; 21. supporting part; 3. reagent box 31. first side; 32. second side; 4. right linkage positioning module; 41. connecting member; 411. movable groove; 412. bending part; 413. connecting hole; 42. side push positioning plate; 421. second abutting part; 422. second positioning step; 423. marble hole; 43. linkage member; 44. follow-up bearing; 45. side push positioning plate fixing module; 451. guide groove; 5. drive positioning module; 51. main positioning plate; 511. connecting groove; 512. first abutting part, 513. first positioning step; 52. driving member 521. movable end; 53. driving member movable detection member; 6. left linkage positioning module. DETAILED DESCRIPTION

[0054] The following is a clear and complete description of the technical solutions of the present invention in conjunction with the accompanying drawings. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0055] The utility model provides a reagent box positioning assembly for fixing a reagent box 3 placed on a base 1, comprising: a driving positioning module 5, and at least one linkage positioning module 4 driven by the driven positioning module, wherein the driving positioning module 5 and the linkage positioning module 4 jointly fix and limit the reagent box 3, wherein the driving positioning module 5 comprises: a main positioning plate 51 for fixing the first side 31 of the reagent box 3 and a driving member 52 capable of driving the main positioning plate 51, the movable end 521 of the driving member 52 is connected to the main positioning plate 51, and the main positioning plate 51 is located above the base 1; the linkage positioning module 4 has a side-pushing positioning plate 42 for fixing any one of the two adjacent second side edges 32 of the first side edge 31; when the movable end 521 drives the main positioning plate 51 away from or close to the base 1 in the Y-axis direction, the main positioning plate 51 drives the side-pushing positioning plate 42 to also move away from or close to the base 1 in the X-axis direction.

[0056] Specifically: the initial state of the reagent kit positioning component of the present invention is the positioning state, that is, Figure 8 or Figure 3 As shown, the movable end portion 521 of the driving member 52 drives the main positioning plate 51 to approach the base 1 along the Y-axis direction and the side push positioning plate 42 to approach the base 1 along the X-axis direction; before the reagent box is placed, the reagent box positioning assembly of the utility model is adjusted from the positioning state to the non-positioning state, that is, Figure 1 As shown, the movable end portion 521 of the driving member 52 drives the main positioning plate 51 away from the base 1 along the Y-axis direction and the side push positioning plate 42 away from the base 1 along the X-axis direction; after the reagent kit is placed, the reagent kit positioning assembly of the present invention is adjusted from a non-positioning state to a positioning state, and the reagent kit positioning assembly is able to fix and clamp the reagent kit to ensure that it does not shift or even be lifted during the purification process; after the purification and extraction process is completed, the reagent kit positioning assembly of the present invention is adjusted from a positioning state to a non-positioning state, making it convenient to remove the reagent kit. The reagent kit positioning assembly provided by the present invention does not need to be pressed down when the reagent kit is placed, and can be automatically placed in by the matching transport assembly, and is also compatible with manual placement; after the reagent kit is processed, it can be automatically positioned, and can be automatically moved out by the matching transport assembly, and is also compatible with manual removal.

[0057] In one embodiment, the linkage positioning module 4 further includes: a connecting member 41, which is connected to the main positioning plate 51 and moves away from or closer to the base 1 along the Y-axis direction along with the main positioning plate 51. In the process of the connecting member 41 moving away from or closer to the base 1 along the Y-axis direction along with the main positioning plate 51, the side push positioning plate 42 is driven to move linearly along the X-axis direction. Specifically, Figure 4-6As shown, when the connecting member 41 moves away from or close to the base 1 along the Y-axis direction with the main positioning plate 51, it drives the side push positioning plate 42 to move linearly in the X-axis direction, so that the driving positioning module 5 and the linkage positioning module 4 work together to fix and limit the reagent kit 3.

[0058] In another embodiment, the connection member 41 and the main positioning plate 51 are detachably connected; and / or, the fixed position between the connection member 41 and the main positioning plate 51 is adjustable in the X-axis direction; further, the connection member 41 is provided with a plurality of connection holes 413 in parallel for screws to pass through and fix to adjust the fixed position; further, the main positioning plate 51 is provided with a connection groove 511 for the connection of the connection member 41, and the fixed position is within the connection groove 511. Specifically, as Figure 8-9 As shown, the connection between the connector 41 and the main positioning plate 51 is detachable, and the fixed position of the connector 41 and the main positioning plate 51 can be adjusted according to the size of the reagent kit, which reduces the requirements for the external dimensions of the reagent kit and can be used even when there are certain size differences.

[0059] In another embodiment, the linkage positioning module 4 further includes: a side push positioning plate fixing module 45, the side push positioning plate fixing module 45 has a guide groove 451 arranged parallel to the base 1 in the X-axis direction, and the side push positioning plate 42 is guided by the guide groove 451 so that the side push positioning plate 451 is guided to move linearly in the direction of the X-axis. Specifically, Figure 4-6 As shown, the side push positioning plate fixing module 45 may have a guide groove 451 matching the outer edge of the side push positioning plate 42 , and the side push positioning plate 42 moves linearly along the guide groove 451 in the direction of the X axis.

[0060] In another embodiment, the side push positioning plate fixing module 45 has two guide grooves 451 symmetrically arranged on both sides of the side push positioning plate 42. Figure 4-6 As shown, the side push positioning plate fixing module 45 can be two symmetrically arranged fixing blocks, and the two fixing blocks are symmetrically provided with guide grooves 451 to fix the side push positioning plate 42 left and right.

[0061] In another embodiment, the linkage positioning module 4 further includes: a linkage member 43, one end of the linkage member 43 is fixed to the side push positioning plate 42, the connecting member 41 is arranged parallel to the base 1 in the X-axis direction, and has a 90-degree bend in the Y-axis direction, and the side push positioning plate 42 is driven to move linearly in the X-axis direction by bending, and the bending forms a bending portion 412 in the Y-axis direction, and the bending portion 412 is provided with a movable groove 411 for the other end of the linkage member 43 to move, and the movable groove 411 has an angle with the X-axis direction, further, the movable groove 411 is arranged in parallel in multiples, and / or the linkage member 43 is arranged in multiple corresponding movable grooves 411; further, the bend is a rounded bend. Specifically, in the non-positioning state, such as Figure 1 As shown, the connecting member 41 moves away from the base 1 along the Y-axis direction, driving the linkage member 43 and the follower bearing 44 to move along the movable groove 411, and the movable groove 411 has an angle with the X-axis direction, so the side push positioning plate 42 moves away from the base 1 along the X-axis direction; in the positioning state, as shown Figure 3 As shown in FIG8 , the connecting member 41 approaches the base 1 along the Y-axis direction, driving the linkage member 43 and the follower bearing 44 to move along the movable groove 411 , and the movable groove 411 has an angle with the X-axis direction, so the side push positioning plate 42 approaches the base 1 along the X-axis direction.

[0062] In another embodiment, the outer periphery of the linkage member 43 is provided with a follower bearing 44, and the follower bearing 44 is arranged in the movable groove 411. Specifically, Figure 4-6 As shown, the follower bearing 44 serves to reduce the movement resistance of the linkage member 43.

[0063] In another embodiment, Figure 2 As shown, the side of the main positioning plate 51 that contacts the first side 31 is a first abutting portion 512 , and the first abutting portion 512 is provided with an inwardly recessed first positioning step 513 for positioning the protruding extension portion at the bottom of the first side 31 .

[0064] In another embodiment, Figure 4-7 As shown, the side where the side push positioning plate 42 contacts the second side edge 32 is a second abutting portion 421, and the second abutting portion 421 is provided with an inward-recessed second positioning step 422 for positioning the protruding extension portion at the bottom of the second side edge 32; further, the second abutting portion 421 is also provided with a marble hole 423 located above the second positioning step 422 for loading marbles, which is used for limiting the marbles on the second side edge 32; further, the marble holes 423 are multiple and parallel.

[0065] Specifically, when in the positioning state, Figure 10 As shown, the first locking step 513 of the main positioning plate 51 locks the protruding extension at the bottom of the first side 31 of the reagent box 3, while the second locking step 422 of the side-pushing positioning plate 42 locks the protruding extension at the bottom of the second side 32 of the reagent box 3. In the non-positioning state, the first locking step 513 of the main positioning plate 51 is away from the protruding extension at the bottom of the first side 31 of the reagent box 3, while the second locking step 422 of the side-pushing positioning plate 42 is away from the protruding extension at the bottom of the second side 32 of the reagent box 3. After the reagent box 3 is positioned, it is firmly fixed and the reagent box 3 will not be displaced or even lifted during the purification process.

[0066] In another embodiment, the reagent box positioning assembly has two linkage positioning modules 4, and the two linkage positioning modules 4 share a main positioning plate 51 and a driving member 52. Specifically, Figure 1 、 3 As shown in , 8 or 9 , the two linkage positioning modules 4 share one driving positioning module 5 . Generally, the two linkage positioning modules 4 are respectively arranged on the left and right of the driving positioning module 5 , and can complete the positioning of the two reagent kits 3 on the left and right at the same time.

[0067] In another embodiment, the reagent kit positioning assembly further comprises a base 1, such as Figure 1 、 3 As shown in FIG11 , the driving member 52 is arranged below the base 1 .

[0068] In another embodiment, the base 1 is provided with a reagent box; further, the reagent box is provided with a transverse bar 11 for fixing the opposite side of the first side 31 of the reagent box 3 in the X-axis direction, and the reagent box is provided with a longitudinal bar 12 for fixing the opposite side of the second side 32 of the reagent box 3 in the Y-axis direction. Specifically, Figure 1 、 3 , 8, 9 or 11, when the reagent kit 3 is fixed, it abuts against the transverse baffle 11 and the longitudinal baffle 12 of the reagent kit placement block, and the reagent kit placement block helps to smoothly position the reagent kit.

[0069] In another embodiment, the base 1 is provided with two reagent box placement blocks, and further, two reagent boxes 3 are placed side by side and share a longitudinal block 12. Specifically, the left and right reagent boxes 3 are placed side by side and share a longitudinal block 12. In conjunction with the two linkage positioning modules 4 provided for the left and right reagent boxes 3 and the drive positioning module 5 located between the two linkage positioning modules 4, the left and right reagent boxes 3 can be positioned simultaneously.

[0070] In another embodiment, the reagent box positioning assembly further includes a support module for fixing the support base 1. Further, the support module has at least two symmetrically arranged support blocks 2. Further, the support block 2 also has a supporting portion 21. The supporting portion 21 is in an inverted "Z" shape. The supporting portion 21 is arranged on the outside of the support block 2, and the top of the supporting portion 21 is used to fix the side push positioning plate fixing module 45. Further, the top of the supporting portion 21 is at the same height as the base 1. Specifically, as Figure 1 、 3 -6 or 11, the top of the supporting portion 21 is used to fix the side push positioning plate fixing module 45, so that the base 1 can use the existing base 1 without re-molding and manufacturing a base 1 with a widened version relative to the existing base.

[0071] The present invention also provides an automatic positioning device for a reagent box, which has a reagent box positioning component and a control module as described in the above technical solution. The control module communicates with the driving member 52 to control the driving member 52 to move away from or close to the base 1.

[0072] In one embodiment, the control module further includes a driving member activity detection member 53, which is provided on the driving member 52 for detecting the moving position of the movable end 521 and transmitting the position information of the movable end 521 to the outside. Figure 3 As shown, the driving member movable detection member 53 is set on the driving member 52 to detect the moving position of the movable end 521 and transmit the position information of the movable end 521 to the outside, thereby feeding back whether the reagent cartridge positioning assembly of the present invention is in the positioning state.

[0073] The present invention also provides a purification device having a reagent kit positioning component as described above or an automated positioning device as described above, further comprising: Figure 11 As shown, the purification equipment also includes any one or more of the following:

[0074] (1) A magnetic rod assembly, including a magnetic rod holder for mounting the magnetic rod;

[0075] (2) a magnetic rod sleeve assembly, including a magnetic rod sleeve frame for installing the magnetic rod sleeve, the magnetic rod sleeve frame is located below the magnetic rod frame, and each magnetic rod can be correspondingly inserted into the corresponding magnetic rod sleeve;

[0076] (3) a studio for arranging a magnetic rod assembly, a magnetic rod sleeve assembly, and a placement assembly, wherein the placement assembly includes a reagent box placement block;

[0077] (4) a moving mechanism for driving the magnetic rod sleeve and / or the magnetic rod frame to move vertically and / or horizontally, further, the moving mechanism includes a horizontal moving mechanism and a vertical moving mechanism, further, the moving mechanism includes a horizontal moving mechanism for driving the magnetic rod assembly and the magnetic rod sleeve assembly to move horizontally, and a first vertical moving mechanism for respectively driving the magnetic rod assembly to move vertically and a second vertical moving mechanism for driving the magnetic rod sleeve assembly to move vertically;

[0078] (5) Circuit structure, including a circuit structure integrated board for controlling the purification equipment to implement the purification operation;

[0079] (6) a heat dissipation device for dissipating heat from the working room;

[0080] (7) a disinfection device for disinfecting the workroom;

[0081] (8) Any one or more of (1)-(7) are arranged on the base.

[0082] The present invention also provides a purification system having the purification equipment and the transport component according to the above technical solution, wherein the control module and the transport component communicate with each other to control the transport component to transport the reagent kit 3 .

[0083] "Purification" in this application refers to the extraction or separation of target biomolecules using magnetic bead purification to obtain purified target biomolecules. Purified target biomolecules include, but are not limited to, nucleic acids and proteins. Purification of nucleic acids and purification of proteins are semantically equivalent to the more common expressions "nucleic acid extraction" and "protein purification." Furthermore, the "purification" process can include, for example, extraction from a cell lysate followed by purification by magnetic bead adsorption, or it can simply be purification by magnetic bead adsorption.

[0084] In the above embodiments, the purification equipment is used for purification of nucleic acids, proteins and genomes, immune cell sorting and bacterial enrichment, and / or, the equipment is suitable for but not limited to multi-well kits, large-capacity multi-well kits or deep-well plates, kits or deep-well plates for extraction and purification of biomolecules, and kits or deep-well plates for purification of biomolecules. Multi-well kit and test kit have the same meaning and are not particularly limited. Any commercially available multi-well kit or deep-well plate, such as 24-well, 48-well, 96-well, 192-well, 384-well, 768-well, or 1536-well, can be used. A large-capacity multi-well kit or deep-well plate refers to a standard multi-well kit or multi-well plate with increased processing well length and processing volume, such as the sample loading plate disclosed in CN 218491693 U containing at least one large-capacity well and at least two standard wells. A kit or deep-well plate for extraction and purification of biomolecules, or a kit or deep-well plate for purification of biomolecules refers to a purification kit or deep-well plate designed to contain any set number of sample loading wells according to purification requirements. Furthermore, the purification kit or deep-well plate is added with purification reagents such as a magnetic bead suspension, buffer, washing solution, and eluent before use.

[0085] The above description is only a preferred embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A reagent box positioning assembly, used to fix a reagent box placed on a base, characterized in that: include: A driving positioning module and at least one linkage positioning module driven by the driving positioning module, wherein the driving positioning module and the linkage positioning module jointly fix and limit the reagent box, wherein: The driving and positioning module comprises: a main positioning plate for fixing the first side of the reagent box and a driving member capable of driving the main positioning plate, wherein the movable end of the driving member is connected to the main positioning plate, and the main positioning plate is located above the base; The linkage positioning module has a side push positioning plate for fixing any one of the two adjacent second side edges of the first side edge; When the movable end drives the main positioning plate to move away from or closer to the base in the Y-axis direction, the main positioning plate drives the side push positioning plate to move away from or closer to the base in the X-axis direction accordingly.

2. The reagent kit positioning assembly according to claim 1, characterized in that: The linkage positioning module further includes: a connecting member, which is connected to the main positioning plate and moves away from or close to the base along the Y-axis direction with the main positioning plate. Wherein, when the connecting member moves away from or approaches the base along with the main positioning plate in the Y-axis direction, the side push positioning plate is driven to move linearly in the X-axis direction.

3. The reagent kit positioning assembly according to claim 2, characterized in that: The connecting member is detachably connected to the main positioning plate; and / or, the fixed position between the connecting member and the main positioning plate is adjustable in the X-axis direction.

4. The reagent kit positioning assembly according to claim 3, characterized in that: The connecting piece is provided with a plurality of connecting holes in parallel for screw rods to penetrate and fix so as to adjust the fixing position.

5. The reagent kit positioning assembly according to claim 3, characterized in that: The main positioning plate is provided with a connecting groove for the connecting member to connect, and the fixed position is in the connecting groove.

6. The reagent kit positioning assembly according to claim 1, characterized in that: The linkage positioning module also includes: a side push positioning plate fixing module, the side push positioning plate fixing module has a guide groove arranged parallel to the base in the X-axis direction, and the side push positioning plate is guided by the guide groove so that the side push positioning plate is guided to move linearly in the direction of the X-axis.

7. The reagent kit positioning assembly according to claim 6, characterized in that: The side push positioning plate fixing module has two guide grooves symmetrically arranged on both sides of the side push positioning plate.

8. The reagent kit positioning assembly according to claim 2, characterized in that: The linkage positioning module further includes: a linkage member, one end of which is fixed to the side push positioning plate. The connecting member is arranged parallel to the base in the X-axis direction and has a 90-degree bend in the Y-axis direction. The side push positioning plate is driven to move linearly in the X-axis direction through the bend. The bend forms a bending portion in the Y-axis direction. The bending portion is provided with an active groove for the other end of the linkage member to move, and the active groove has an angle with the X-axis direction.

9. The reagent kit positioning assembly according to claim 8, characterized in that: The movable grooves are arranged in parallel in plurality, and / or the linkage members are arranged in plurality corresponding to the movable grooves.

10. The reagent kit positioning assembly according to claim 8, characterized in that: The bend is a rounded bend.

11. The reagent kit positioning assembly according to claim 8, characterized in that: A follower bearing is sleeved on the outer periphery of the linkage member, and the follower bearing is arranged in the movable groove.

12. The reagent kit positioning assembly according to claim 1, characterized in that: The side of the main positioning plate in contact with the first side edge is a first abutting portion, and the first abutting portion is provided with a first recessed positioning step for positioning the protruding extension portion at the bottom of the first side edge.

13. The reagent kit positioning assembly according to any one of claims 1 to 12, characterized in that: The side of the side push positioning plate in contact with the second side edge is a second abutting portion, and the second abutting portion is provided with an inwardly recessed second positioning step for positioning the bottom extension portion of the second side edge.

14. The reagent kit positioning assembly according to claim 13, characterized in that: The second abutting portion is also provided with a marble hole located above the second positioning step for loading marbles, which is used for limiting the marble position of the second side.

15. The reagent kit positioning assembly according to claim 14, characterized in that: Furthermore, the marble holes are arranged in parallel in multiple numbers.

16. The reagent kit positioning assembly according to any one of claims 1 to 12, characterized in that: There are two linkage positioning modules, and the two linkage positioning modules share one main positioning plate and the driving member.

17. The reagent kit positioning assembly according to any one of claims 1 to 12, characterized in that: The utility model also includes the base, and the driving member is arranged below the base.

18. The reagent kit positioning assembly according to claim 17, characterized in that: The base is provided with a reagent box placement block.

19. The reagent kit positioning assembly according to claim 18, characterized in that: The reagent box placement block is provided with a transverse blocking bar for fixing the opposite side of the first side of the reagent box in the X-axis direction, and the reagent box placement block is provided with a longitudinal blocking bar for fixing the opposite side of the second side of the reagent box in the Y-axis direction.

20. The reagent kit positioning assembly according to claim 19, characterized in that: The base is provided with two reagent box placement blocks.

21. The reagent kit positioning assembly according to claim 20, characterized in that: The two reagent kits are placed side by side and share one longitudinal baffle.

22. The reagent kit positioning assembly according to claim 17, characterized in that: Also included is a supporting module for fixedly supporting the base.

23. The reagent box positioning assembly according to claim 22, characterized in that: The supporting module has at least two symmetrically arranged supporting blocks.

24. The reagent kit positioning assembly according to claim 23, characterized in that: The support block also has a supporting portion, which is in an inverted "Z" shape. The supporting portion is arranged on the outside of the support block, and the top of the supporting portion is used to fix the side push positioning plate fixing module.

25. The reagent kit positioning assembly according to claim 24, characterized in that: The top of the supporting portion is at the same height as the base.

26. An automated positioning device for a reagent kit, characterized in that: A reagent box positioning assembly and a control module as described in any one of claims 1 to 25 are provided, wherein the control module communicates with the driving member to control the driving member to perform the operation of moving away from or approaching the base.

27. The automated positioning device according to claim 26, characterized in that: The control module further comprises a driving member activity detection member, wherein the driving member activity detection member is arranged on the driving member and is used for detecting the moving position of the movable end and transmitting the position information of the movable end to the outside.

28. A purification device, characterized in that: It has any one of the reagent kit positioning components as described in claims 1-25 or has the automated positioning device as described in claim 26 or 27.

29. The purification device according to claim 28, characterized in that The purification equipment may further include any one or more of the following: (1) a magnetic bar assembly, including a magnetic bar rack for mounting the magnetic bar; (2) a magnetic rod sleeve assembly, comprising a magnetic rod sleeve frame for installing the magnetic rod sleeve, wherein the magnetic rod sleeve frame is located below the magnetic rod frame, and each of the magnetic rods can be correspondingly inserted into the corresponding magnetic rod sleeve; (3) a working room, used to set the magnetic rod assembly, the magnetic rod sleeve assembly and the placement assembly, wherein the placement assembly includes a reagent box placement block; (4) a moving mechanism, used to drive the magnetic rod sleeve and / or the magnetic rod frame to move vertically and / or horizontally, further, the moving mechanism includes a horizontal moving mechanism and a vertical moving mechanism, further, the moving mechanism includes a horizontal moving mechanism for driving the magnetic rod assembly and the magnetic rod sleeve assembly to move horizontally and a first vertical moving mechanism for driving the magnetic rod assembly to move vertically and a second vertical moving mechanism for driving the magnetic rod sleeve assembly to move vertically; (5) a circuit structure, including a circuit structure integrated board for controlling the purification device to implement the purification operation; (6) a heat dissipation device for dissipating heat from the working room; (7) a disinfection device for disinfecting the working room; (8) Any one or more of (1)-(7) are arranged on the base.

30. A purification system, characterized in that: The purification device and the transport component as described in claim 28 are provided, and the control module communicates with the transport component to control the transport component to transport the reagent kit.

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