Fluorescence imaging equipment capable of rapidly processing tissue slices

By introducing rotating components and locking components into fluorescence imaging devices, combining visible light and near-infrared laser cameras, batch imaging of multiple slice samples is achieved, solving the problems of limited imaging numbers and single functions of existing devices, and improving detection Efficiency and imaging quality.

CN222364911UActive Publication Date: 2025-01-17CHANGCHUN JIZHI FLUORESCENT BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202420702043.3
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-04-08
Publication Date
2025-01-17
Estimated Expiration
2034-04-08

AI Technical Summary

Technical Problem

Existing fluorescence imaging devices can only image a single tissue section, which cannot meet the needs of rapid detection of large numbers of samples, and have a single function, affecting imaging efficiency.

Method used

An operating box including visible and near-infrared lasers and cameras is designed, equipped with rotating components and locking components to realize automatic shooting and batch imaging of multiple slices, supporting dual-channel detection of visible and near-infrared, improving detection efficiency and imaging quality.

Benefits of technology

It realizes efficient batch imaging of multiple slice samples, improves detection efficiency and imaging quality, and enhances the functionality and operation convenience of the equipment.

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Abstract

The utility model discloses fluorescence imaging equipment capable of rapidly processing tissue slices, and aims to provide the fluorescence imaging equipment capable of rapidly processing the tissue slices, which is convenient for batch imaging, improves the detection efficiency, improves the functionality and improves the imaging efficiency. A visible light laser, a visible light camera, a near-infrared laser and a near-infrared camera are installed on the top in the operation box, a rotating assembly is movably connected to the bottom in the operation box, the rotating assembly is provided with a rotating shaft, one end of the rotating shaft is rotationally connected with the rotating assembly, and the other end of the rotating shaft is connected with a rotating disc which is provided with a slice containing groove. The multiple slice containing grooves are arranged around the circle center of the rotary disc, the rotary disc is connected with a locking assembly, and the locking assembly is movably connected with the slice containing grooves. The beneficial effects of the utility model are that the device has the multifunctionality of visible light and near infrared dual-channel imaging; slice samples can be imaged in batches, so that the detection efficiency is improved; and the use convenience and the operation efficiency of the equipment are improved.
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Description

Technical Field

[0001] The utility model relates to the technical field of fluorescence imaging equipment, in particular to a fluorescence imaging equipment capable of rapidly processing tissue slices. Background Art

[0002] Fluorescence imaging technology has the advantages of high sensitivity and high resolution, real-time dynamic observation, multi-parameter detection and multi-channel imaging, non-invasive and non-destructive testing, and data quantification and analysis. These advantages make fluorescence imaging technology an indispensable tool in life science and medical research, providing scientists with more in-depth, accurate and comprehensive research methods. During tumor surgery, doctors will remove tumors or tissues whose nature cannot be clearly determined. Pathology professionals will make slices after sampling, rapid cooling, slicing, staining, etc., and finally observe under a microscope to make a pathological diagnosis. Intraoperative frozen pathology examination is a very valuable surgical auxiliary tool, but after freezing, the deformation of tissue cells affects the judgment, the accuracy is poor, the time is long, and it is heavily dependent on the practical experience of pathologists. With the development of fluorescence imaging technology, rapid fluorescence imaging of tumor lesions has become an effective auxiliary means to accurately visualize the location and boundaries of tumors. This method can help medical staff measure the distance of the cutting edge, find residual tumor cells in the cutting edge, and formulate further surgical plans.

[0003] China Patent Authorization Announcement Number: CN 217717520 U, Authorization Announcement Date: November 1, 2022. The utility model relates to a digital pathology slice scanner for research institutes, including a scanner body and a fixing mechanism arranged inside the scanner body, characterized in that: the fixing mechanism includes a sliding assembly; the sliding assembly includes a threaded sliding tooth plate, a connecting slider, a sliding groove rod and a limit plate, and a first threaded rod is arranged inside the scanner body, one end of the first threaded rod is fixedly connected to a first knob, and the outer wall of the first threaded rod is threadedly connected to a threaded sliding tooth plate. The shortcomings of this technical solution are: 1. The scanner can only image a single tissue slice and cannot meet the needs of rapid detection of a large number of samples; 2. The function of the scanner is single, which affects the imaging efficiency.

[0004] In summary: the limited number of imaging slices in the imaging device and the difficulty in batch imaging reduce the detection efficiency, and the single function affects the imaging efficiency. Utility Model Content

[0005] The utility model aims to overcome the shortcomings of the imaging equipment in the prior art, such as the limited number of imaging slices, difficulty in batch imaging, reduced detection efficiency, single function, and impact on imaging efficiency, and provides a fluorescent imaging device that can quickly process tissue slices and is convenient for batch imaging, improves detection efficiency, enhances functionality, and improves imaging efficiency.

[0006] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0007] A fluorescent imaging device capable of rapidly processing tissue slices comprises an operating box, wherein a visible light laser, a visible light camera, a near-infrared laser and a near-infrared camera are installed on the top of the operating box, wherein a rotating assembly is movably connected to the bottom of the operating box, wherein the rotating assembly is provided with a rotating shaft, wherein one end of the rotating shaft is rotatably connected to the rotating assembly, and the other end of the rotating shaft is connected to a turntable, wherein the turntable is provided with a slice placement slot, wherein a plurality of slice placement slots are provided and arranged around the center of the turntable, wherein the turntable is connected with a locking assembly, and the locking assembly is movably connected to the slice placement slot.

[0008] A visible light laser, a visible light camera, a near-infrared laser and a near-infrared camera are installed on the top of the operation box to observe and image the slices below, thereby realizing combined dual-channel detection imaging of visible light and near-infrared. A rotating assembly is installed at the bottom of the operation box to support and drive the connected rotating shaft to rotate, so that the turntable connected to the rotating shaft rotates below the visible light laser, the visible light camera, the near-infrared laser and the near-infrared camera. At the same time, a number of slice placement slots are evenly arranged on the turntable to place and fix the slices, so that each slice is automatically photographed by the visible light laser, the visible light camera, the near-infrared laser and the near-infrared camera during rotation, and visible light and near-infrared signals are collected at the same time, and visible area images, near-infrared area images and superimposed images are clearly displayed, so as to realize efficient and batch processing of slices, so that the tissue slice imaging device can quickly detect and image a large number of samples. The slice placement slot is connected to the locking assembly to facilitate the start of placing and taking out, and to batch lock the slices in the imaging state, thereby improving the imaging quality. The device has the versatility of dual-channel imaging of visible light and near-infrared, and the detection efficiency is improved by batch imaging of sliced ​​samples. The slices are easy to pick up and fix, which improves the convenience of device operation and detection stability, thereby improving efficiency and imaging quality.

[0009] Preferably, the locking assembly comprises a first limiting seat, a second limiting seat, a push rod and a locking rod, wherein the first limiting seat and the second limiting seat are both provided with a card slot, the first limiting seat is fixedly connected to the slice placement slot, the locking rod is rotatably connected to the turntable, one end of the push rod is connected to the locking rod, and the second limiting seat is movably connected to the slice placement slot through the other end of the push rod. In the locking assembly, the first limiting seat and the second limiting seat are both placed in the slice placement slot, wherein the first limiting seat is fixedly connected to the slice placement slot to locate the placement position of one end of the slice through the card slot and ensure the imaging accuracy of the instrument, the second limiting seat can be moved in the slice placement slot, thereby facilitating the rapid placement of the slice, after placement, the other end of the slice is locked by pushing the second limiting seat through the push rod, and the second limiting seat is moved in the opposite direction to achieve relaxation, thereby facilitating the unlocking and easy removal; the push rod pushes the second limiting seat through the rotational connection of the locking rod and the turntable, and the operation is simple and the pushing rods connected to the locking rod can be operated simultaneously to synchronize the locking in accordance with the imaging requirements of the batch, thereby improving the operation and use efficiency of the equipment. The effect of ensuring imaging accuracy, quickly taking and fixing slice samples, and improving equipment operation efficiency is achieved.

[0010] Preferably, the turntable is connected with a fixed screw, which is connected at the center of the turntable, and the locking rod is threadedly connected to the fixed screw. The turntable is a disc-shaped structure and is connected to a fixed screw with an external thread at the center. The locking rod is provided with an inner groove with an internal thread so that the locking rod can be threadedly connected to the fixed screw, and then the push rod is driven to push the second limit seat through the rotation of the thread. The threaded engagement improves the convenience and stability of operation and makes the coordination of the structural parts stable and efficient. The effect of improving the operability and stability of the structure is achieved.

[0011] Preferably, the slice placement groove is provided with a guide slide hole, the second limit seat is connected with a guide slider, and the guide slider is slidably connected with the guide slide hole. A guide slide hole is provided in the slice placement groove, so that the second limit seat follows the guide slider to move linearly in the guide slide hole, thereby improving the structural operation stability and the slice sample positioning accuracy.

[0012] Preferably, the turntable is connected with a fixed block and a reset spring, the fixed block is connected with a guide rod, the guide rod is plugged into the guide slider, the reset spring is sleeved with the guide rod, one end of the reset spring is connected to the fixed block, and the other end of the reset spring is connected to the guide slider. The lower end surface of the turntable is connected with the fixed block and the reset spring, and the guide rod is plugged into the guide slider, so that the movement of the second limit seat is more stable and the locking stability is prevented from being affected by the push rod force. In addition, the reset spring connected to the fixed block is connected to the guide slider, so that after the second limit seat loses the push rod pushing force, the reset spring drives the guide slider (second limit seat) to reset, and then the second limit seat is distanced from the first limit seat again to facilitate the rapid removal of the slice sample and the placement of the next batch of slice samples. The effect of improving the stability of the coordinated operation between the structures and the operating efficiency of the equipment is achieved.

[0013] Preferably, the rotating assembly includes a motor box, a rotating mechanism, gear 1, gear 2 and a base, the motor box is movably connected to the operating box, the rotating mechanism and the base are both placed in the motor box and connected to the motor box, gear 1 is connected to the rotating mechanism, the base is equipped with a bearing, the rotating shaft is connected to the bearing, gear 2 is connected to the rotating shaft, and gear 1 is meshed with gear 2. The motor box in the rotating assembly is connected to the operating box and can be moved, so that the motor box including the rotating shaft connected to the bearing of the motor box can be conveniently entered and exited from the operating box, so as to facilitate the placement and removal of the slice sample, wherein the rotating mechanism is installed in the motor box and connected to gear 1 to drive gear 1 to rotate, gear 2 is fixedly sleeved on the rotating shaft connected to the bearing, so that the rotating shaft can rotate and stop through the meshing of gear 1 and gear 2, and the bearing improves the smoothness of rotation. The effect of achieving stability between structures and smoothness of operation is achieved.

[0014] Preferably, the operating box is provided with a limiting slide, the limiting slide is provided with a slide, one side of the slide is plugged into the limiting slide, the other side of the slide is connected to the motor box, the slide is provided with a handle through hole, the operating box is hinged with a door, and the handle through hole is placed on the side of the slide close to the door. The side of the operating box is hinged with a door to facilitate the entry and exit of the motor box and the turntable, and the motor box is connected with a slide, and the slide is plugged into the limiting slide at the bottom of the operating seat box, so that the motor box can slide out and enter the operating box in a guided manner, thereby realizing the positioning and movement of the motor box and the turntable with high efficiency and precision. The effect of improving the positioning accuracy of imaging and the efficiency of equipment use is achieved.

[0015] The beneficial effects of the utility model are as follows: the device has the versatility of dual-channel imaging of visible light and near-infrared; the detection efficiency is improved by batch imaging of slice samples; the slices are easy to take and fix, which improves the convenience of device operation and detection stability, thereby improving efficiency and imaging quality; the structural operation stability and slice sample positioning accuracy are improved to ensure imaging accuracy; and the convenience of use and operating efficiency of the device are improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a three-dimensional diagram of the utility model;

[0017] Figure 2 yes Figure 1 A cross-sectional view of

[0018] Figure 3 It is a schematic diagram of the structure of the turntable.

[0019] In the figure: 1. operating box, 2. visible light laser, 3. visible light camera, 4. near-infrared laser, 5. near-infrared camera, 6. rotating shaft, 7. turntable, 8. slice placement groove, 9. locking assembly, 10. first limit seat, 11. second limit seat, 12. push rod, 13. locking rod, 14. slot, 15. fixing screw, 16. guide slide hole, 17. guide slide block, 18. fixing block, 19. reset spring, 20. guide rod, 21. motor box, 22. rotating mechanism, 23. gear one, 24. gear two, 25. base, 26. bearing, 27. limit slide groove, 28. slide plate, 29. handle through hole, 30. box door, 31. power control box, 32. support block, 33. ejector rod, 34. stable bracket, 35. positioning groove, 36. connecting arm. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all of the embodiments. The following description of at least one exemplary embodiment is actually only illustrative and is by no means intended to limit the present application and its application or use. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0021] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present application. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprise" and / or "include" are used in this specification, it indicates the presence of features, steps, operations, devices, components and / or combinations thereof.

[0022] Unless otherwise specifically stated, the relative arrangement, numerical expressions and numerical values ​​of the parts set forth in these embodiments do not limit the scope of the application. For ease of explanation, spatial relative terms such as "upper", "lower", "left", "right" are used in the embodiments to illustrate the relationship between an element or feature shown in the figures relative to another element or feature. It should be understood that, in addition to the orientation shown in the figures, spatial terms are intended to include different orientations of the device in use or operation. For example, if the device in the figure is inverted, the element described as being "under" other elements or features will be positioned "on" other elements or features. Therefore, the exemplary term "under" can include both upper and lower orientations. The device may be otherwise oriented (rotated 90 degrees or at other orientations), and the spatial relative descriptions used herein may be interpreted accordingly. At the same time, it should be understood that for ease of description, the sizes of the various parts shown in the drawings are not drawn according to the actual scale. Technologies, processes, and equipment known to ordinary technicians in the relevant field may not be discussed in detail, but where appropriate, technologies, processes, and equipment should be considered as part of the authorized specification. In all examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not limiting. Therefore, other examples of the exemplary embodiments may have different values. It should be noted that similar reference numerals and letters represent similar items in the following figures, and therefore, once an item is defined in one figure, it does not need to be further discussed in subsequent figures.

[0023] In addition, it should be noted that the use of terms such as "first" and "second" to limit components is only for the convenience of distinguishing the corresponding components. Unless otherwise stated, the above terms have no special meaning and therefore cannot be understood as limiting the scope of protection of this application.

[0024] Embodiment 1:

[0025] like Figure 1 , 2 As shown, a fluorescence imaging device that can quickly process tissue slices includes an operating box 1. A visible light laser 2, a visible light camera 3, a near-infrared laser 4 and a near-infrared camera 5 are installed on the top of the operating box 1. The bottom of the operating box 1 is movably connected with a rotating component. The rotating component is provided with a rotating shaft 6. One end of the rotating shaft 6 is rotatably connected to the rotating component. The other end of the rotating shaft 6 is connected to a turntable 7. The turntable 7 is provided with a slice placement slot 8. There are several slice placement slots 8 and they are arranged around the center of the turntable 7. The turntable 7 is connected with a locking component 9, and the locking component 9 is movably connected to the slice placement slot 8.

[0026] like Figure 2 , 3As shown, the locking assembly 9 includes a first limit seat 10, a second limit seat 11, a push rod 12 and a locking rod 13. The first limit seat 10 and the second limit seat 11 are both provided with a slot 14. The first limit seat 10 is fixedly connected to the slice placement slot 8, the locking rod 13 is rotatably connected to the turntable 7, one end of the push rod 12 is connected to the locking rod 13, and the second limit seat 11 is movably connected to the slice placement slot 8 through the other end of the push rod 12.

[0027] like Figure 2 As shown, the rotating disk 7 is connected with a fixing screw 15 , the fixing screw 15 is connected at the center of the rotating disk 7 , and the locking rod 13 is threadedly connected to the fixing screw 15 .

[0028] like Figure 2 , 3 As shown, the slice placement groove 8 is provided with a guide slide hole 16, the second limit seat 11 is connected to a guide slide block 17, and the guide slide block 17 is slidably connected to the guide slide hole 16. The turntable 7 is connected to a fixed block 18 and a return spring 19, the fixed block 18 is connected to a guide rod 20, the guide rod 20 is plugged into the guide slide block 17, the return spring 19 is sleeved with the guide rod 20, one end of the return spring 19 is connected to the fixed block 18, and the other end of the return spring 19 is connected to the guide slide block 17.

[0029] like Figure 2 As shown, the rotating assembly includes a motor box 21, a rotating mechanism 22, a gear one 23, a gear two 24 and a base 25. The motor box 21 is movably connected to the operating box 1. The rotating mechanism 22 and the base 25 are both placed in the motor box 21 and connected to the motor box 21. The gear one 23 is connected to the rotating mechanism 22. The base 25 is equipped with a bearing 26. The rotating shaft 6 is connected to the bearing 26. The gear two 24 is connected to the rotating shaft 6. The gear one 23 is meshed with the gear two 24.

[0030] like Figure 2 As shown, the operating box 1 is provided with a limiting slide groove 27, the limiting slide groove 27 is provided with a slide plate 28, one side of the slide plate 28 is plugged into the limiting slide groove 27, and the other side of the slide plate 28 is connected to the motor box 21, the slide plate 28 is provided with a handle through hole 29, the operating box 1 is hinged with a box door 30, and the handle through hole 29 is placed on the side of the slide plate 28 close to the box door 30.

[0031] like Figure 1-3 As shown: a power control box 31 is installed on the top outside the operating box 1, and the power control box 31 is electrically connected to the visible light laser 2, the visible light camera 3, the near-infrared laser 4 and the near-infrared camera 5 and the rotating mechanism 22 (using a rotating motor) for electrically controlling the switching operation of each instrument.

[0032] A support block 32 is provided in the operating box, and a push rod 33 is provided in the support block 32. One end of the push rod 33 is threadedly connected to the support block 32, and the other end of the push rod 33 is rotatably connected to a stabilizing bracket 34. The stabilizing bracket 34 is movably connected to the operating box 1 through the push rod 33. The stabilizing bracket 34 is provided with a positioning groove 35, and the slide plate 28 is clamped with the positioning groove 35 to firmly fix the slide plate 28 in the operating box 1 to prevent affecting the imaging stability.

[0033] The near-infrared camera 5 uses an ultra-high quantum efficiency, deeply cooled back-illuminated scientific research-grade CCD camera and ultra-low temperature semiconductor cooling, and has a powerful capture capability for weak signals.

[0034] The operating box 1 is equipped with an illumination light source, and a high-power LED is used as the excitation light source. The global light source adopts a shadowless symmetrical light source arrangement method, which can output evenly distributed excitation light. Combined with the fluorescence correction algorithm that meets the AMST standard, the excitation energy irradiated on the sample is kept consistent to avoid result errors caused by uneven illumination. Compared with halogen lamps, high-power LEDs as excitation light sources have the characteristics of longer life, higher efficiency, and less attenuation, making fluorescence excitation more efficient and reducing result errors caused by factors such as light source attenuation. At the same time, it has visible light and near-infrared continuously adjustable laser light sources, which are suitable for detection of fluorescent reagents of different wavelengths.

[0035] The visible light laser 2, the visible light camera 3, the near-infrared laser 4 and the near-infrared camera 5 are all connected with a connecting arm 36, and the connecting arm 36 is installed on the top of the operating box 1 to ensure the stability of the connection between the visible light laser 2, the visible light camera 3, the near-infrared laser 4 and the near-infrared camera 5.

[0036] This example uses tumor tissue slices as an example to explain the use of the device. The tumor tissue slices are pre-processed before entering the device, that is, the tumor tissue slices are placed in a phosphate-buffered saline solution of the fluorescent probe and incubated for 3 minutes. After the incubation, they are rinsed three times with phosphate-buffered saline containing 30% PEG-400, each rinse for 0.5 minutes. The specimen is then imaged using the tissue slice fluorescence imaging system:

[0037] Open the operation box 1, turn the top rod 33, so that the stable bracket 34 leaves the slide 28 during the upward movement of the top rod 33, and pulls the slide 28 out through the handle through hole 29, and the turntable 7 moves synchronously out of the operation box 1 to load slices in batches. The sliced ​​samples are placed in the locking assembly 9: one right-angled side of the sliced ​​sample is inserted into the slot 14 of the first limit seat 10, and the other side is quickly placed on the second limit seat 11. This embodiment is based on the standard of batch processing of ten sliced ​​samples each time, and then the sliced ​​samples are placed in the ten slice placement slots 8 in turn according to the above operation method, and then the turntable 7 is kept fixed and the locking rod 13 is turned, so that the ten push rods 12 on the locking rod 13 push the corresponding second limit seats 11 (such as Figure 3 As shown in the figure, the second limit seat 11 gradually clamps the slice sample into the clamping slot 14 under the guidance of the guide slider 17, and the ten slice samples are locked synchronously. The slide plate 28 is pushed into the operation box 1 (pushed to the bottom), the top rod 33 is turned to make the positioning slot 35 clamp into the slide plate 28 again, and the box door 30 is closed. The slice sample can be imaged by turning on the power of the power control box 31, wherein the rotating mechanism 22 drives the rotation of the rotating shaft 6, so that the ten slice samples are sequentially collected by the visible light laser 2, the visible light camera 3, the near-infrared laser 4 and the near-infrared camera 5 in the device. Visible light and near-infrared signals are collected simultaneously, and then the visible area image, the near-infrared area image and the superimposed image can be clearly transmitted and displayed, so that the tissue slice fluorescence imaging device can image the specimen and observe the fluorescence intensity and tumor contour.

[0038] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features thereof may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A fluorescence imaging device capable of rapidly processing tissue sections, characterized in that: The invention comprises an operation box (1), wherein a visible light laser (2), a visible light camera (3), a near-infrared laser (4) and a near-infrared camera (5) are installed on the top of the operation box (1), and a rotating assembly is movably connected to the bottom of the operation box (1), wherein the rotating assembly is provided with a rotating shaft (6), one end of the rotating shaft (6) is rotatably connected to the rotating assembly, and the other end of the rotating shaft (6) is connected to a rotating disk (7), wherein the rotating disk (7) is provided with a slice placement groove (8), wherein a plurality of slice placement grooves (8) are provided and arranged around the center of the rotating disk (7), and wherein the rotating disk (7) is connected with a locking assembly (9), and wherein the locking assembly (9) is movably connected to the slice placement groove (8).

2. A fluorescence imaging device capable of rapidly processing tissue sections according to claim 1, characterized in that: The locking assembly (9) comprises a first limiting seat (10), a second limiting seat (11), a push rod (12) and a locking rod (13); the first limiting seat (10) and the second limiting seat (11) are both provided with a clamping groove (14); the first limiting seat (10) is fixedly connected to the slice placement groove (8); the locking rod (13) is rotatably connected to the turntable (7); one end of the push rod (12) is connected to the locking rod (13); and the second limiting seat (11) is movably connected to the slice placement groove (8) via the other end of the push rod (12).

3. A fluorescence imaging device capable of rapidly processing tissue sections according to claim 2, characterized in that: The rotating disk (7) is connected to a fixing screw (15), the fixing screw (15) is connected at the center of the rotating disk (7), and the locking rod (13) is threadedly connected to the fixing screw (15).

4. A fluorescence imaging device capable of rapidly processing tissue sections according to claim 3, characterized in that: The slice placement groove (8) is provided with a guide sliding hole (16), the second limit seat (11) is connected with a guide sliding block (17), and the guide sliding block (17) is slidably connected to the guide sliding hole (16).

5. A fluorescence imaging device capable of rapidly processing tissue sections according to claim 4, characterized in that: The rotating disk (7) is connected to a fixed block (18) and a return spring (19); the fixed block (18) is connected to a guide rod (20); the guide rod (20) is plugged into the guide slider (17); the return spring (19) is sleeved with the guide rod (20); one end of the return spring (19) is connected to the fixed block (18); and the other end of the return spring (19) is connected to the guide slider (17).

6. A fluorescence imaging device capable of rapidly processing tissue sections according to claim 1, characterized in that: The rotating assembly comprises a motor box (21), a rotating mechanism (22), a gear 1 (23), a gear 2 (24) and a base (25); the motor box (21) is movably connected to the operating box (1); the rotating mechanism (22) and the base (25) are both placed in the motor box (21) and connected to the motor box (21); the gear 1 (23) is connected to the rotating mechanism (22); a bearing (26) is installed on the base (25); the rotating shaft (6) is connected to the bearing (26); the gear 2 (24) is connected to the rotating shaft (6); and the gear 1 (23) is meshingly connected to the gear 2 (24).

7. A fluorescence imaging device capable of rapidly processing tissue sections according to claim 6, characterized in that: The operating box (1) is provided with a limiting slide groove (27), the limiting slide groove (27) is provided with a slide plate (28), one side of the slide plate (28) is plugged into the limiting slide groove (27), the other side of the slide plate (28) is connected to the motor box (21), the slide plate (28) is provided with a handle through hole (29), the operating box (1) is hinged with a box door (30), and the handle through hole (29) is placed on the side of the slide plate (28) close to the box door (30).

Citation Information

Patent Citations

  • Digital pathological section scanner for research institute

    CN217717520U