Sample analyzer
By rationally arranging the functional modules of the sample analyzer and adopting independent gripper and mixing mechanisms, the problem of low detection throughput in traditional sample analyzers has been solved, achieving efficient transfer and mixing of reaction cups and improving detection efficiency.
Patent Information
- Application Number
- CN202420265644.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-02-04
- Publication Date
- 2025-01-21
- Estimated Expiration
- 2034-02-04
AI Technical Summary
Traditional sample analyzers have low throughput, mainly due to the fixed positions of the mechanical gripper and mixing unit, resulting in low transport efficiency and inability to efficiently manage reaction vessels.
Design a sample analyzer that rationally arranges the functional modules and employs two independent gripper mechanisms and an independent mixing mechanism to achieve efficient transfer and mixing of reaction cups, thereby increasing detection throughput.
The design of independent gripper and mixing mechanisms improves the transfer and mixing efficiency of the reaction vessel, thereby enhancing the detection throughput of the sample analyzer.
Smart Images
Figure CN222379711U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the field of sample detection devices, in particular to a sample analyzer. Background Art
[0002] The sample analyzer is an instrument used to perform quantitative analysis on target analytical substances such as antibodies and antigens contained in test samples such as human blood, cerebrospinal fluid, and tears. It usually adds the sample to be tested and the target reagent into a clean reaction cup container and goes through processes such as mixing, incubation, washing and separation. Then, a heavy suspension is added to the reaction cup container and mixed, and finally quantitative detection is performed in the detection system.
[0003] The sample analyzer can be divided into several relatively independent units according to its functional units, such as consumables feeding, sample reagent distribution, mixing, incubation, cleaning magnetic separation, and detection. The reaction cup containers are dispatched between each unit by a transfer robot to complete the entire test process. In the entire test process, mixing is required after adding samples or target reagents at each step, and then entering the incubation process after mixing, so mixing also runs through the entire test process. As an important indicator parameter to measure the work efficiency of the sample analyzer per unit time, the detection flux is defined as the number of samples to be tested completed by the sample analyzer per unit time.
[0004] The low test efficiency of traditional sample analyzers is that some processes take a long time. According to the division of each functional unit of the sample analyzer and their respective functional attributes, the mechanical gripper and mixing are two units that affect the efficiency of the entire process. The mechanical gripper is used to dispatch the reaction cup container to move between the consumable feeding unit, incubation unit, magnetic separation unit, mixing unit and detection unit. The mechanical gripper mainly has two forms: linear motion and circular motion. The linear motion mainly has three-dimensional motion or two-dimensional motion, and the motion range is wider than that of circular motion. Mixing can be set as an independent unit function at the sample reagent addition position for mixing after sample reagent addition, but this means that its installation position needs to be fixed and it cannot be transported between the sample addition position, incubation position and magnetic separation position to improve the sample transportation efficiency, thereby improving the detection throughput. Utility Model Content
[0005] In order to solve the problems of the prior art, the utility model provides a sample analyzer, which reasonably arranges the various functional modules of the sample analyzer, reduces the volume, can meet different scheduling processes, increases the number of reaction cup containers on the input and output mixing mechanisms per unit time and the transportation efficiency of the reaction cup containers, and ultimately improves the detection throughput.
[0006] The utility model provides a sample analyzer, comprising a tip gun head consumables mechanism, a sample bin, a reagent bin, a reaction cup feeding bin, an incubation mechanism, a mixing mechanism, a magnetic separation mechanism, a gripper mechanism and a detection mechanism outside the base, the reaction cup feeding bin comprising a reaction cup arrangement mechanism and a reaction cup buffer mechanism, the mixing mechanism comprising a first mixing station and a second mixing station, the gripper mechanism comprising a first gripper mechanism and a second gripper mechanism, the first gripper mechanism and the second gripper mechanism being located in different planes, wherein the motion range of the first gripper mechanism covers the incubation mechanism, the mixing mechanism and the reaction cup buffer mechanism, the center line of the cup gripper of the first gripper mechanism, the center line of the first mixing station or the second mixing station on the mixing mechanism, and the center line of the cup taking position on the reaction cup buffer mechanism are located on the same straight line; the motion range of the second gripper mechanism covers the first magnetic separation mechanism, the second magnetic separation mechanism, the mixing mechanism and the detection mechanism, and the center line of the cup gripper of the second gripper mechanism, the center lines of the first mixing station and the second mixing station on the mixing mechanism are located on the same straight line.
[0007] As a further improvement, the reagent bin and reaction cup feed bin are located on the left side of the mixing mechanism, and the sample bin, tip consumables mechanism, incubation mechanism, first magnetic separation mechanism, second magnetic separation mechanism, first gripper mechanism and second gripper mechanism are located on the right side of the mixing mechanism. Such a layout has high overall operating efficiency.
[0008] As a further improvement, the sample bin includes a sample recovery area, a sample injection area, and a sample injection channel arranged between the sample injection area and the sample recovery area, and a sample adding position is arranged at the end of the sample injection channel; the sample injection area accommodates multiple sample test tube racks, and each test tube rack simultaneously places multiple sample test tubes; the sample test tube rack on the injection area is transported to the sample injection channel by a conveying mechanism, and after the sample information is identified and the sample is taken in the sample injection channel, it is then transported to the sample recovery area by the conveying mechanism. The conveying mechanism on the sample bin is a synchronous belt drive, a linear motor lead screw drive, a gear rack drive, or a chain drive. An emergency area is arranged on the sample bin, and the emergency area accommodates at least 2 test tube racks.
[0009] As a further improvement, the reagent compartment includes a reagent loading mechanism and a reagent loading station.
[0010] Further improvement, the tip gun consumable mechanism performs one-dimensional movement along the Y-axis direction of the base, including four tip head boxes, wherein the first tip head box and the fourth tip head box constitute a first unit, the second tip head box and the third tip head box constitute a second unit, and the first unit and the second unit move independently. The purpose of this design is to facilitate the replacement of tip head consumables and meet the needs of online replacement of tip head consumables of the instrument.
[0011] As a further improvement, the incubation mechanism performs one-dimensional movement along the Y-axis direction of the base, and includes an incubation block, an incubation position and a self-mixing mechanism, which is used to heat the samples and reagents in the reaction cup container to achieve incubation; the self-mixing mechanism is an eccentric mechanism, a synchronous belt mechanism, or a cam mechanism.
[0012] As a further improvement, the magnetic separation area includes a first magnetic separation mechanism and a second magnetic separation mechanism, which are arranged side by side on the same side of the incubation mechanism and are used for washing non-specific substances during the reaction of samples and reagents.
[0013] As a further improvement, the mixing mechanism is used for rapid mixing of samples and reagents, and includes a belt drive component and an eccentric mixing component. The belt drive component drives the eccentric mixing component to perform one-dimensional movement along the Y-axis direction of the base.
[0014] The beneficial effects of the utility model are:
[0015] 1. By setting up independent mixing mechanisms and grippers, it can travel through the incubation position, sample addition position, reagent addition position, and magnetic separation position to meet the scheduling of different processes.
[0016] 2. Two grippers without physical connection can operate independently and without interference, saving their respective operating time and eliminating waiting time in queues. The two grippers operate simultaneously, which improves the operating efficiency of the grippers, thereby increasing the number of reaction cup containers on the input and output mixing mechanism per unit time, thereby increasing the detection throughput.
[0017] 3. By setting up an independent mixing mechanism, the mixing mechanism can not only assume the function of transporting the reaction cup container, but also realize the rapid mixing of samples and reagents, so that rapid mixing can be achieved during the process of transporting the reaction cup container, further improving the transportation efficiency of the reaction cup container, and ultimately increasing the detection throughput. BRIEF DESCRIPTION OF THE DRAWINGS
[0018] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.
[0019] Figure 1 Figure 2 is a layout diagram of the sample analyzer.
[0020] The reference numerals in the figures are as follows:
[0021] 100. tip gun consumables mechanism; 110. first tip head box; 120. second tip head box; 130. third tip head box; 140. fourth tip head box;
[0022] 200. Sample compartment; 210. Sample injection area; 220. Sample injection channel; 230. Sample recovery area; 240. Sample addition position
[0023] 300. Reagent bin; 310. Reagent loading mechanism; Reagent loading station 320;
[0024] 400. Reaction cup feeding bin; 410. Reaction cup arrangement mechanism; 420. Reaction cup buffer mechanism; 421. Indexing plate;
[0025] 500. Mixing mechanism; 510. First mixing station; 520. Second mixing station;
[0026] 600. Incubation mechanism; 610. Incubation block; 6101. Incubation position;
[0027] 700. Magnetic separation area; 710. First magnetic separation mechanism; 720. Second magnetic separation mechanism; 7101. First sample introduction station; 7201. Second sample introduction station;
[0028] 800. First gripper mechanism;
[0029] 900. Second gripping mechanism. DETAILED DESCRIPTION
[0030] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.
[0031] See also Figure 1 The utility model provides a sample analyzer, which specifically includes a tip gun consumables mechanism 100, a sample bin 200, a reagent bin 300, a reaction cup feed bin 400, a mixing mechanism 500, an incubation mechanism 600, a first magnetic separation mechanism 710, a second magnetic separation mechanism 720, a first gripper mechanism 800, and a second gripper mechanism 900. Taking the mixing mechanism 500 as a reference, the reagent bin 300, the reaction cup feed bin 400 including the reaction cup arrangement mechanism 410 and the reaction cup arrangement mechanism 420 can be located on the left side of the mixing mechanism 500, and the sample bin 200, the tip gun consumables mechanism 100, the incubation mechanism 600, the first magnetic separation mechanism 710, the second magnetic separation mechanism 720, the first gripper mechanism 800, and the second gripper mechanism 900 can be located on the right side of the mixing mechanism 500. Such a layout has high overall operating efficiency.
[0032] In one embodiment, the tip consumable mechanism 100 is used to store disposable tip tips, the sample compartment 200 is used to place samples to be tested, the reagent compartment 300 is used to store reagents for testing different items, and the reaction cup supply compartment 400 is used to store disposable reaction cup containers. The tip consumable mechanism 100 is located on the right side of the sample compartment 200, the reaction cup supply compartment 400 is located on the rear side of the reagent compartment 300, and the reagent compartment 300 is located on the left side of the sample compartment 200. A mixing mechanism 500 is provided between the reagent compartment 300 and the sample compartment 200. The sample compartment 200 is arranged in a "U" shape, wherein the right side of the sample compartment 200 is a sample injection area 210, the left side of the sample compartment 200 is a sample recovery area 230, and between the sample injection area 210 and the sample recovery area 230 is a sample injection channel 220, wherein the sample injection area 210 can accommodate multiple sample test tube racks, at least 5 test tube racks, and each test tube rack can simultaneously hold 5 sample test tubes.
[0033] Furthermore, an emergency area is provided on the sample compartment 200, and the emergency area can accommodate at least two test tube racks;
[0034] During operation, the sample test tube rack on the sample injection area 210 of the sample compartment 200 is transported to the sample injection channel 220 by the transport mechanism, and after the sample information is identified and the sample is taken in the sample injection channel 220, it is transported to the sample recovery area 230 by the transport mechanism;
[0035] Furthermore, the conveying mechanism on the sample chamber 200 may be a synchronous belt drive, a linear motor screw drive, a gear rack drive, or a chain drive.
[0036] Furthermore, the tip gun consumable mechanism 100 can perform one-dimensional movement along the Y-axis direction in the C region, wherein the first tip head box 110 and the fourth tip head box 140 form a first unit, and the second tip head box 120 and the third tip head box 120 form a second unit, and the first unit and the second unit can move independently. The purpose of this design is to facilitate the replacement of tip head consumables and meet the needs of online replacement of tip head consumables of the instrument;
[0037] In one embodiment, the reaction cup supply bin 400 is used to store clean disposable reaction cup containers. The reaction cup arrangement mechanism 410 is located at the rear side of the reaction cup supply bin 400 and is used to arrange and organize the reaction cup containers so that the reaction cup containers enter the reaction cup buffer mechanism 420 in a certain queue form in sequence. The indexing plate 421 is used to allow the reaction cup containers to enter the reaction cup container retrieval station in sequence. When working, the first gripper mechanism 800 grabs the reaction cup and moves along the X-axis direction to the top of the reaction cup buffer mechanism 420, grabs the reaction cup container, and transports it to the first mixing station 510 or the second mixing station 520 of the mixing mechanism 500. The mixing mechanism 500 moves to the sample adding station 240 for sample adding operation. The mixing mechanism 50 0 continues to move to the next station, namely the reagent loading station 320, and then the reagent loading mechanism 310 takes out the reagent of the corresponding project from the reagent compartment 300, and the reagent loading mechanism 310 moves to the reagent loading station 320 to perform the reagent loading operation. In view of the fact that the sample has been added to the reaction cup container at the sample loading station 240 and the reagent has been added to the reagent loading station 320, the mixing mechanism 500 can immediately perform the mixing action to quickly mix the sample and reagent solution in the reaction cup container. The mixing mechanism 500 can continue to perform the mixing action process during the transfer to the next station. Of course, if the timing allows, the mixing action can be performed when the mixing mechanism is stationary, which is also allowed. This mainly depends on the arrangement of the timing process of the entire machine.
[0038] Furthermore, before the mixing mechanism 500 moves to the reagent loading station 320 , the reagent loading mechanism 310 can extract the reagent of the corresponding project from the reagent chamber 300 in advance, and wait for the mixing mechanism 500 to move to the reagent loading station 320 after moving to the reagent loading station 320 .
[0039] In one embodiment, the mixing mechanism 500 is used for rapid mixing of samples and reagents, and includes a belt drive assembly and an eccentric mixing assembly. The belt drive assembly drives the eccentric mixing mechanism to move within the dotted rectangle A to achieve rapid transfer of the reaction cup container.
[0040] Furthermore, the mixing mechanism 500 is provided with at least two mixing stations, namely a first mixing station 510 and a second mixing station 520 .
[0041] During operation, after the first mixing station 510 adds a cuvette container, it moves to the sample adding station 240 to add a sample. After the sample adding is completed, the mixing mechanism 500 moves to the reagent adding station 320 to add a reagent, and then the mixing mechanism 500 immediately performs the mixing action. During the mixing operation of the mixing mechanism 500, the mixing mechanism 500 can move to the vicinity of the cuvette buffer mechanism 420 to add a new cuvette to the second mixing station 520, or when the incubation of the cuvette container of a certain process is completed, the first gripper mechanism 800 grabs the cuvette container in the incubation mechanism 600 and places it in the second mixing station 520; of course, the cuvette container after the magnetic separation of a certain process is completed can also be grabbed by the second gripper mechanism 900 and placed in the second mixing station 520, and then the subsequent action process is performed, and the cuvette container is moved from the reagent adding station 320 to the second mixing station 520. The time for the first gripper mechanism 800 to move to the incubation and cup adding position must be greater than the time for the first gripper mechanism 800 to grab the cup from the incubation mechanism 600 and place it in the second mixing station 520. Similarly, the time for the reaction cup container to move from the reagent adding station 320 to the magnetic separation and cup adding position xxx must be greater than the time for the second gripper mechanism 900 to grab the reaction cup container from the first magnetic separation mechanism 710 or the second magnetic separation mechanism 720 to the second mixing station 520. This shortens the queuing "waiting time", which is equal to the sum of the time for adding samples or reagents to the reaction container, the movement time of the mixing mechanism, and the mixing time. If the queuing waiting time is less than the time for the reaction cup gripper to grab the cup from the incubation mechanism 600 and place it in the second mixing station 520, it will cause the time for two adjacent reaction cup containers to enter or exit the mixing mechanism 500 to be longer, the detection efficiency is low, and the detection throughput is difficult to improve;
[0042] In one embodiment, the incubation mechanism 600 is independently arranged on the mixing mechanism 500, and the incubation mechanism 600 is used to heat the samples and reagents in the reaction cup container to realize the incubation function. The incubation mechanism 600 can realize one-dimensional movement, and performs one-dimensional movement in the dotted rectangle B along the Y-axis direction shown in the figure. The incubation mechanism 600 also has a self-mixing function, so that the sample and reagent react more fully during the incubation process. The self-mixing function of the incubation mechanism 600 can be an eccentric mechanism, a synchronous belt mechanism, or a cam mechanism or other mechanism that can realize the mixing function. The incubation mechanism can realize one-dimensional movement, and the first gripper mechanism 800 with two-dimensional movement can cover the incubation position 6101 of the entire incubation mechanism 600, and the first gripper mechanism 800 can accurately grasp the reaction cup container of each incubation position on the incubation mechanism 600.
[0043] In one embodiment, the movement range of the first gripper mechanism 800 can cover the incubation mechanism 600, the mixing mechanism 500, and the cuvette buffer mechanism 420. The first gripper can transfer the cuvette container on the cuvette buffer mechanism 420 to the mixing mechanism 500, add a new cuvette container to the mixing mechanism, and then the new cuvette container moves with the mixing mechanism 500 to the sample position or the reagent position to add the sample. After adding the sample and the reagent, the cuvette container continues to move to the incubation and addition waiting position, and the first gripper grabs the cuvette container and moves it to the incubation mechanism 600. For the cuvette container located on the incubation mechanism 600, after the incubation is completed, the first gripper grabs the sample and reagent cuvette container that have completed the incubation and moves them to the mixing mechanism 500.
[0044] Furthermore, the center line of the cup gripper of the first gripper mechanism 800, the center line of the first mixing station 510 or the second mixing station 520 on the mixing mechanism 500, and the center line of the cup taking position on the reaction cup buffer mechanism 420 are located on the same straight line, which is conducive to the gripper accurately grasping the reaction cup container.
[0045] In one embodiment, the magnetic separation area 700 is independently arranged on the right side of the incubation mechanism 600, including a first magnetic separation mechanism 710 and a second magnetic separation mechanism 720, which are arranged side by side on the same side, and are used to wash non-specific substances during the reaction of samples and reagents, and to clean the object to be tested to remove interfering impurities, thereby achieving the cleaning of the object to be tested. When the cleaning is completed, the second gripper 720 moves the reaction cup container out of the first magnetic separation mechanism 710 or the second magnetic separation mechanism 720 and transports it to the mixing mechanism 500 to continue to add the next reagent component for reaction. The second gripper 720 can also move the reaction cup container out of the first magnetic separation mechanism 710 or the second magnetic separation mechanism 720 and transport it to the resuspension detection mechanism (not shown in the figure), and then add the resuspension liquid to the reaction cup container and mix it, so that the detection device can detect the sample to be tested.
[0046] Furthermore, the movement range of the second gripping mechanism 900 can cover the first magnetic separation mechanism 710, the second magnetic separation mechanism 720, the mixing mechanism 500 and the detection mechanism, and the center line of the cup gripping hand of the second gripping mechanism 900 and the center lines of the first mixing station 510 and the second mixing station 520 on the mixing mechanism 500 are on the same straight line.
[0047] Furthermore, the first gripper mechanism 800 and the second gripper mechanism 900 are located in different planes and can operate independently of each other without interfering with each other, which effectively solves the interference problem of the two grippers themselves and improves the operating efficiency of the two grippers respectively, thereby achieving high efficiency.
[0048] The sample analyzer can perform two test project processes on the sample, mainly divided into sample dilution test process and sample non-dilution process. There are differences between the two in the early stage of the test, and the work flow steps of the two in the later stage of the test are the same. The early work steps of the sample dilution process are introduced as follows:
[0049] S1, the first gripper mechanism 800 takes the cuvette container out of the cuvette buffer mechanism 420 and moves it to the first mixing station 510 on the mixing mechanism 500, and then the mixing mechanism 500 moves to the sample adding position so that the disposable tip mechanism adds the sample in the sample chamber 200 to the cuvette container on the first mixing station 510; after the sample addition is completed, the mixing mechanism 500 continues to move to the reagent adding position, and the reagent adding mechanism 310 takes out the diluent from the reagent chamber 300 and adds it to the first mixing position. After the diluent is added to the reaction cup container on the mixing station 510, the mixing mechanism 500 starts mixing and moves to the reaction cup container adding position, the first gripper mechanism 800 continues to add new reaction cup containers to the second mixing station 520 on the mixing mechanism 500, the mixing mechanism 500 moves to the sample adding position, and the disposable tip gun head mechanism takes out a certain amount of the diluted new sample to be tested from the first mixing station 510 on the mixing mechanism 500 and puts it into the new reaction cup container on the second mixing station 520;
[0050] S2, the mixing mechanism 500 moves to the reagent adding position, the reagent adding mechanism 310 takes out the reagent components from the reagent compartment 300 and adds them to the reaction cup container on the second mixing station 520. After the reagent is added, the mixing mechanism 500 starts mixing and moves to the incubation adding position;
[0051] S3, the first gripper mechanism 800 moves the cuvette container containing the new sample and reagent on the second mixing station 520 of the mixing mechanism 500 to the incubation mechanism 600 for incubation, which is recorded as "first incubation";
[0052] S4, the mixing mechanism 500 moves to the cup throwing position, and the second gripper mechanism 900 throws the reaction cup container on the first station 510 of the mixing mechanism 500 to the waste recovery mechanism;
[0053] S5, add the sample that needs to be diluted and repeat the process of S1 to S4;
[0054] S6, after the incubation is completed, the first gripper mechanism 800 moves the reaction cup container in the incubation mechanism 600 to one of the first mixing station 510 or the second mixing station 520 in the mixing mechanism 500;
[0055] S7, the mixing mechanism 500 moves to the magnetic separation station, and the second gripper mechanism 900 moves the incubated cuvette container to the magnetic separation mechanism 700 to wash the object to be tested, which is recorded as "the first magnetic separation";
[0056] S8, for the one-step method, after the first magnetic separation, the second gripper mechanism 900 moves the cuvette container to the resuspension detection mechanism, adds the resuspension liquid and mixes it, and then starts the detection process;
[0057] S9, after the detection is completed, the second gripper mechanism 900 moves the discarded cuvette container to the waste recovery mechanism;
[0058] S10, for the two-step method, after the first magnetic separation is completed, the second gripper mechanism 900 moves the reaction cup container to one of the first mixing station 510 or the second mixing station 520 on the mixing mechanism 500, and the mixing mechanism continues to run to the reagent adding position to add a new second reagent component. After the reagent is added, the mixing mechanism starts mixing and runs to the incubation adding position. The first gripper mechanism 800 moves the reaction cup container to the incubation mechanism 600 for incubation, which is recorded as "second incubation". After the second incubation is completed, the process of S6 to S7 is repeated and recorded as "second magnetic separation". After the second magnetic separation is completed, the second gripper mechanism 900 moves the reaction cup container to the resuspension detection mechanism, adds the resuspension liquid and mixes, and then starts the detection process;
[0059] S11, after the detection is completed, repeat the S9 process;
[0060] S12, for the three-step method, after the second magnetic separation is completed, the second gripper mechanism 900 moves the reaction cup container to one of the first mixing station 510 or the second mixing station 520 on the mixing mechanism 500, and the mixing mechanism continues to run to the reagent adding position to add new reagent components. After the reagent addition is completed, the mixing mechanism starts mixing and runs to the incubation adding position. The first gripper mechanism 800 moves the reaction cup container to the incubation mechanism 600 for incubation, which is recorded as "the third incubation". After the third incubation is completed, the process of S6 to S7 is repeated and recorded as "the third magnetic separation". After the third magnetic separation is completed, the second gripper mechanism 900 moves the reaction cup container to the resuspension detection mechanism, adds the resuspension liquid and mixes, and then starts the detection process;
[0061] S13, after the detection is completed, repeat the S9 process.
[0062] For samples that do not need to be diluted, the process is different from that for samples that need to be diluted as follows:
[0063] S1, the first gripper mechanism 800 takes out the cuvette container from the cuvette buffer mechanism 420 and moves it to the first mixing station 510 or the second mixing station 520 on the mixing mechanism 500, and then the mixing mechanism 500 moves to the sample adding position so that the disposable tip gun head mechanism adds the sample in the sample chamber 200 to the cuvette container on the first mixing station 510 or the second mixing station 520; after the sample addition is completed, the mixing mechanism 500 continues to move to the reagent adding position, and the reagent adding mechanism 310 takes out the added reagent components from the reagent chamber 300 and adds them to the cuvette container on the first mixing station 510 or the second mixing station 520;
[0064] S2, after the reagent components are added, the mixing mechanism 500 starts mixing and transfers the reaction cup container to the incubation station;
[0065] The following process is the same as the process S3 to S13 of the above-mentioned dilution sample;
[0066] Therefore, the sample analyzer can simultaneously perform one-step, two-step, and three-step tests on different items, that is, while one-step item tests are being performed in some reaction cup containers, two-step and three-step item tests can be performed in other reaction cup containers, that is, the same sample analyzer satisfies multiple test processes and can complete the test in an orderly and rapid manner.
[0067] For the sample analyzer of the above-mentioned process, if the first gripper mechanism 800 and the second gripper mechanism 900 are combined into one gripper, that is, only one gripper is used, when the reaction cup container containing the sample to be tested on the incubation mechanism 600 reaches the incubation time and needs to enter the next process, at the same time, a reaction cup container in the first magnetic separation mechanism 710 or the second magnetic separation mechanism 720 also needs to be moved out of the magnetic separation mechanism, one gripper can only be responsible for grabbing one of the above reaction cup containers to execute the corresponding next action process, which causes another reaction cup container to wait in line, thereby reducing the working efficiency of the incubation mechanism or the magnetic separation mechanism, and then reducing the number of reaction containers input and output from the incubation mechanism or the magnetic separation mechanism within the unit, and ultimately reducing the detection flux.
[0068] As for the sample analyzer in the above embodiment, the mixing mechanism 500 is independently set, which can be more flexibly scheduled. When a new reaction cup container needs to be added, the mixing mechanism can be moved to the vicinity of the cache mechanism 420 to wait for the addition of the new reaction cup container; when the reaction cup container to which the sample and reagent have been added needs to be incubated, the mixing mechanism transfers the reaction cup container to the incubation position and waits for the first gripper to transfer it to the incubation mechanism for incubation; similarly, when the sample to be tested needs to be magnetically separated, the mixing mechanism transfers the reaction cup container to the magnetic separation position and waits for the second gripper to transfer the reaction cup container to the magnetic separation mechanism for magnetic separation and cleaning.
[0069] Each embodiment in this specification is described in a progressive manner, and the same and similar parts between the embodiments can be referred to each other, and each embodiment focuses on the differences from other embodiments. In particular, for the device embodiment, the above is only a preferred implementation of the utility model. Since it is basically similar to the method embodiment, the description is relatively simple, and the relevant parts can be referred to the partial description of the method embodiment. The above is only a specific implementation of the utility model, but the protection scope of the utility model is not limited to this. Any technician familiar with the technical field is within the technical scope disclosed by the utility model. For ordinary technicians in the technical field, changes or replacements that can be easily thought of should be included in the protection scope of the utility model without departing from the principle of the utility model. Therefore, the protection scope of the utility model should be based on the protection scope of the claims.
Claims
1. A sample analyzer, comprising a tip consumable mechanism, a sample compartment, a reagent compartment, a reaction cup feed compartment, an incubation mechanism, a mixing mechanism, a magnetic separation mechanism, a gripper mechanism, and a detection mechanism outside the base, which are integrated and installed on the same base, characterized in that: The reaction cup feeding bin includes a reaction cup organizing mechanism and a reaction cup buffer mechanism, the mixing mechanism includes a first mixing station and a second mixing station, the gripping mechanism includes a first gripping mechanism and a second gripping mechanism, the first gripping mechanism and the second gripping mechanism are located in different planes, wherein the motion range of the first gripping mechanism covers the incubation mechanism, the mixing mechanism, and the reaction cup buffer mechanism, and the center line of the cup gripping hand of the first gripping mechanism, the center line of the first mixing station or the second mixing station on the mixing mechanism, and the center line of the cup taking position on the reaction cup buffer mechanism are located on the same straight line; the motion range of the second gripping mechanism covers the first magnetic separation mechanism, the second magnetic separation mechanism, the mixing mechanism and the detection mechanism, and the center line of the cup gripping hand of the second gripping mechanism, and the center lines of the first mixing station and the second mixing station on the mixing mechanism are on the same straight line.
2. The sample analyzer according to claim 1, characterized in that: The reagent bin and reaction cup feed bin are located on the left side of the mixing mechanism, and the sample bin, tip consumables mechanism, incubation mechanism, first magnetic separation mechanism, second magnetic separation mechanism, first gripper mechanism and second gripper mechanism are located on the right side of the mixing mechanism.
3. The sample analyzer according to claim 1, characterized in that: The sample bin comprises a sample recovery area, a sample injection area and a sample injection channel arranged between the sample injection area and the sample recovery area, and a sample adding position is arranged at the end of the sample injection channel; the sample injection area accommodates a plurality of sample test tube racks, and each test tube rack can simultaneously hold a plurality of sample test tubes; the sample test tube rack on the injection area is transported to the sample injection channel by a transport mechanism, and after the sample information is identified and the sample is taken in the sample injection channel, it is transported to the sample recovery area by the transport mechanism.
4. The sample analyzer according to claim 3, characterized in that: The conveying mechanism on the sample bin is a synchronous belt drive, a linear motor lead screw drive, a gear rack drive, or a chain drive.
5. The sample analyzer according to claim 3, characterized in that: The sample bin is provided with an emergency area, which can accommodate at least two test tube racks.
6. The sample analyzer according to claim 1, characterized in that: The reagent compartment comprises a reagent loading mechanism and a reagent loading station.
7. The sample analyzer according to claim 1, characterized in that: The tip gun consumable mechanism performs one-dimensional movement along the Y-axis direction of the base, and includes four tip head boxes, wherein the first tip head box and the fourth tip head box form a first unit, and the second tip head box and the third tip head box form a second unit, and the first unit and the second unit move independently.
8. The sample analyzer according to claim 1, characterized in that: The incubation mechanism performs one-dimensional movement along the Y-axis direction of the base, and includes an incubation block, an incubation position and a self-mixing mechanism, which is used to heat the samples and reagents in the reaction cup container to achieve incubation; the self-mixing mechanism is an eccentric mechanism, a synchronous belt mechanism, or a cam mechanism.
9. The sample analyzer according to claim 1, characterized in that: The magnetic separation area comprises a first magnetic separation mechanism and a second magnetic separation mechanism, which are arranged side by side on the same side of the incubation mechanism and are used for washing non-specific substances during the reaction of samples and reagents.
10. The sample analyzer according to claim 1, characterized in that: The mixing mechanism is used for rapid mixing of samples and reagents, and comprises a belt drive component and an eccentric mixing component. The belt drive component drives the eccentric mixing component to perform one-dimensional movement along the Y-axis direction of the base.