Preparation device for naphthyridine compound production

Abstract

The utility model discloses a preparation device for naphthyridine compound production, which relates to the technical field of medicine processing equipment, and is characterized by comprising a conical mixing drum, a horizontally rotating stirring rod is arranged in the conical mixing drum, a spiral first stirring blade is arranged on the stirring rod, and a second stirring blade is arranged on the stirring rod. The stirring rod is further provided with a second stirring blade in a conical spiral shape, and the spiral direction of the first stirring blade is opposite to that of the second stirring blade. The first stirring blade and the second stirring blade which are opposite in spiral direction are arranged on the stirring rod, so that the first stirring blade and the second stirring blade convey materials upwards and downwards one by one for stirring, and meanwhile, the angle of the third stirring blade can be adjusted through extrusion force of material accumulation, so that vacancy in the materials is prevented, and the stirring efficiency is improved. Therefore, the effect of uniform stirring is achieved.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmaceutical processing equipment, and more specifically, to a preparation device for producing naphthyridine compounds. Background Art

[0002] Naphthyridine compounds are an important class of natural products and drug building blocks with a wide range of biomedical applications. They can be used to treat a variety of diseases associated with abnormal kinase activity, such as tumors, psoriasis, cirrhosis, diabetes, ophthalmic diseases, rheumatoid arthritis, and many other diseases.

[0003] During the processing, naphthyridine compounds need to be formulated by adding the required dosage of diluents, adhesives, solvents, etc. During the formulation process, these required items need to be evenly mixed with the compounds so that the overall dilution and adhesion of the naphthyridine compounds meet the requirements. Uneven mixing will affect the final naphthyridine compounds.

[0004] Therefore, a new solution needs to be proposed to solve this problem. Utility Model Content

[0005] In view of the shortcomings of the prior art, the purpose of the utility model is to provide a preparation device for the production of naphthyridine compounds. By arranging a first stirring blade and a second stirring blade with opposite spiral directions on the stirring rod, the first stirring blade and the second stirring blade transport the material upward and downward respectively for stirring. At the same time, the third stirring blade can adjust the angle according to the extrusion force of the material accumulation to prevent vacancies from occurring inside the material, resulting in the phenomenon of unstirring, thereby achieving the effect of uniform stirring.

[0006] The above technical purpose of the utility model is achieved through the following technical scheme: a preparation device for the production of naphthyridine compounds, including a conical mixing barrel, a horizontally rotating stirring rod is arranged in the conical mixing barrel, a spiral first stirring blade is arranged on the stirring rod, and a conical spiral second stirring blade is also arranged on the stirring rod, and the spiral directions of the first stirring blade and the second stirring blade are opposite.

[0007] Preferably, a plurality of mounting rods are provided on the stirring rod, a plurality of the mounting rods are fixedly connected to the second stirring blade, a plurality of the mounting rods are provided with mounting frames, each of the mounting frames is movably connected to a third stirring blade, and each of the third stirring blades is consistent with the rotation direction of the stirring rod.

[0008] Preferably, a baffle is provided at the bottom end of the installation frame, and limiting plates corresponding to the baffle are provided on both sides of the third stirring blade, and the rotation axis of the third stirring blade is parallel to the horizontal plane where the baffle is located.

[0009] Preferably, a cover plate which is circular in plan view is provided on the top of the conical mixing barrel, a driving motor is fixedly provided on the center of the cover plate, a driving end of the driving motor passes through the cover plate and is connected with a coaxial clamping block, a clamping groove corresponding to the clamping block is provided on the top of the stirring rod, a slot hole is provided on the bottom end of the conical mixing barrel, and a limiting column corresponding to the slot hole is provided on the bottom end of the stirring rod.

[0010] The utility model has the following beneficial effects:

[0011] The staff will pre-engage the limit column on the stirring rod with the groove of the conical mixing barrel, and then put the required compounds and diluents into the conical mixing barrel, and then put the cover plate on the conical mixing barrel so that the locking block corresponds to the locking groove, and then start the drive motor so that the drive motor drives the stirring rod to rotate through the locking block. The rotation of the stirring rod causes the first stirring blade and the second stirring blade to rotate. At the same time, the spiral directions of the first stirring blade and the second stirring blade are opposite, so that the first stirring blade and the second stirring blade can stir the materials in the mixing barrel upward and downward to mix them evenly. The drive motor can drive the stirring rod to rotate back and forth, and the third stirring blade on the mounting rod stirs the materials at the same time. Since the third stirring blade is set to rotate vertically, the internal pressure of the materials piled together will change when the first stirring blade and the second stirring blade are stirring. This is because the third stirring blade will rotate and adjust according to the extrusion force generated by the material to prevent vacancies from occurring inside the accumulated materials, resulting in the phenomenon of unmixing, thereby achieving the effect of uniform mixing. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 It is a structural schematic diagram of the utility model;

[0013] Figure 2 This is a schematic diagram of the structure of the utility model with the conical mixing cylinder and the cover plate in a hidden state;

[0014] Figure 3 This is a structural schematic diagram of the third cone stirring blade and the mounting frame of the utility model;

[0015] Figure 4 This is an exploded view of the third stirring blade and the mounting frame of the cone of the utility model.

[0016] In the figure: 1. conical mixing barrel; 2. stirring rod; 3. first stirring blade; 4. second stirring blade; 5. mounting rod; 6. mounting frame; 7. third stirring blade; 8. baffle; 9. limit plate; 10. cover plate; 11. driving motor; 12. clamping block; 13. clamping slot; 14. slot hole; 15. limit column. DETAILED DESCRIPTION

[0017] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments.

[0018] A preparation device for producing naphthyridine compounds, such as Figures 1 to 4 As shown, it includes a conical mixing barrel 1, a stirring rod 2, a driving motor 11, and a cover plate 10. The stirring rod 2 is provided with a first stirring blade 3, a second stirring blade 4, and a third stirring blade 7.

[0019] refer to Figure 1 and Figure 2 As shown: a slot 14 is provided at the bottom end of the inner wall of the conical mixing barrel 1, a limiting column 15 corresponding to the slot 14 is integrally formed at one end of the stirring rod 2, a through hole is provided at the center of the cover plate 10, the cover plate 10 is fixedly connected to the driving motor 11 by bolts, and a hexagonal clamping block 12 is fixedly provided at the driving end of the driving motor 11 by a flange and bolts, a clamping groove corresponding to the clamping block 12 is provided on the top end of the stirring rod 2, a first stirring blade 3 in a spiral shape is welded on the side wall of the stirring rod 2, a plurality of mounting rods 5 are annularly welded on the outer peripheral wall of the stirring rod 2, a second stirring blade 4 in a conical spiral shape is welded on the mounting rod 5, and the spiral directions of the first stirring blade 3 and the second stirring blade 4 are opposite.

[0020] The staff will pre-engage the limiting column 15 on the stirring rod 2 with the slot 14 of the conical mixing barrel 1, and then put the required compounds and diluents into the conical mixing barrel 1, and then cover the conical mixing barrel 1 with the cover plate 10 so that the engaging block corresponds to the engaging slot, and then start the driving motor 11 so that the driving motor 11 drives the stirring rod 2 to rotate through the engaging block. The rotation of the stirring rod 2 causes the first stirring blade 3 and the second stirring blade 4 to rotate, and at the same time, the spiral directions of the first stirring blade 3 and the second stirring blade 4 are opposite, so that the first stirring blade 3 and the second stirring blade 4 stir the materials in the mixing barrel upward and downward to mix them evenly, and the driving motor 11 can drive the stirring rod 2 to rotate forward and backward.

[0021] refer to Figure 1 , Figure 3 and Figure 4 As shown: each of the mounting rods 5 is welded with a mounting frame 6 which is rectangular in top view, a through hole is opened on the mounting frame 6, shafts rotatably connected to the through hole are arranged on both sides of the third stirring blade 7, a baffle 8 extending toward the third stirring blade 7 is arranged on the bottom end surface of the mounting frame 6, and limit plates 9 extending toward the side walls of the mounting frame 6 are arranged on both sides of the third stirring blade 7, and the rotation axis of the third stirring blade 7 is parallel to the horizontal plane where the baffle 8 is located.

[0022] When the materials in the conical mixing barrel 1 are stirred and mixed, the third stirring blade 7 on the mounting rod 5 stirs the materials at the same time. Since the third stirring blade 7 is arranged to rotate vertically, the internal pressure of the materials piled together will change when the first stirring blade 3 and the second stirring blade 4 are stirring. The third stirring blade 7 will rotate and adjust according to the extrusion force generated by the materials to prevent the accumulation of materials from having gaps inside and causing unstirring.

[0023] Working principle:

[0024] The staff pre-engages the limiting column 15 on the stirring rod 2 with the slot 14 of the conical mixing barrel 1, and then puts the required compounds and diluents into the conical mixing barrel 1, and then covers the conical mixing barrel 1 with the cover plate 10 so that the engaging block corresponds to the engaging slot, and then starts the driving motor 11, so that the driving motor 11 drives the stirring rod 2 to rotate through the engaging block. Due to the rotation of the stirring rod 2, the first stirring blade 3 and the second stirring blade 4 rotate, and at the same time, the spiral directions of the first stirring blade 3 and the second stirring blade 4 are opposite, so that the first stirring blade 3 and the second stirring blade 4 stir the materials in the mixing barrel upward and downward to mix them evenly. The driving motor 11 can drive the stirring rod 2 to rotate forward and backward, and the third stirring blade 7 on the mounting rod 5 stirs the materials at the same time. Since the third stirring blade 7 is set to rotate vertically, when the first stirring blade 3 and the second stirring blade 4 are stirring, the internal pressure of the materials piled together will change. This is because the third stirring blade 7 will rotate and adjust according to the extrusion force generated by the material to prevent vacancies from occurring inside the accumulated materials, resulting in the phenomenon of unmixing, thereby achieving a uniform mixing effect.

[0025] The above is only a preferred embodiment of the present invention. The protection scope of the present invention is not limited to the above embodiments. All technical solutions under the concept of the present invention belong to the protection scope of the present invention. It should be pointed out that for ordinary technicians in this technical field, some improvements and modifications without departing from the principle of the present invention should also be regarded as the protection scope of the present invention.

Claims

1. A preparation device for producing naphthyridine compounds, characterized in that: The invention comprises a conical mixing barrel (1), wherein a horizontally rotating stirring rod (2) is arranged in the conical mixing barrel (1), a first spiral stirring blade (3) is arranged on the stirring rod (2), and a second conical spiral stirring blade (4) is also arranged on the stirring rod (2), wherein the spiral directions of the first stirring blade (3) and the second stirring blade (4) are opposite. The stirring rod (2) is provided with a plurality of mounting rods (5), and the plurality of mounting rods (5) are fixedly connected to the second stirring blade (4). The plurality of mounting rods (5) are provided with mounting frames (6), and each mounting frame (6) is movably connected to a third stirring blade (7), and each third stirring blade (7) rotates in the same direction as the stirring rod (2).

2. The preparation device for producing naphthyridine compounds according to claim 1, characterized in that: A baffle (8) is provided at the bottom end of the installation frame (6), and limiting plates (9) corresponding to the baffle (8) are provided on both sides of the third stirring blade (7), and the rotation axis of the third stirring blade (7) is parallel to the horizontal plane where the baffle (8) is located.

3. The preparation device for producing naphthyridine compounds according to claim 2, characterized in that: The top of the conical mixing barrel (1) is provided with a cover plate (10) which is circular in plan view; a driving motor (11) is fixedly provided at the center of the cover plate (10); a driving end of the driving motor (11) passes through the cover plate (10) and is connected to a coaxial clamping block (12); a clamping groove (13) corresponding to the clamping block (12) is provided at the top end of the stirring rod (2); a slot hole (14) is provided at the bottom end of the conical mixing barrel (1), and a limiting column (15) corresponding to the slot hole (14) is provided at the bottom end of the stirring rod (2).

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