Methyl-beta-cyclodextrin production device
By designing a methyl betacyclodextrin production device including a reactor, a cyclodextrin buffer tank, an additive buffer tank, a filter mesh, a washing kettle and a nanofilter, the methyl betacyclodextrin production device in the prior art has been solved. The problem of low ingredient production efficiency has achieved continuous production and efficient purification of methylbetacyclodextrin.
Patent Information
- Application Number
- CN202423178855.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-23
- Publication Date
- 2025-02-07
- Estimated Expiration
- 2034-12-23
AI Technical Summary
The existing methyl betacyclodextrin production device cannot realize the continuous production of methyl betacyclodextrin, resulting in low production efficiency.
A production device including a reactor, a cyclodextrin buffer tank, an additive buffer tank, a filter mesh, a washing kettle and a nanofiltration filter are designed. The device achieves efficient purification and production of methylbetacyclodextrin by performing preliminary filtration and purification in the reactor, followed by multiple washing and filtration in the washing kettle and nanofiltration.
Continuous production of methylbetacyclodextrin is achieved, which improves production efficiency, and obtains a purer methylbetacyclodextrin through multiple washing and filtration, avoiding the impact on yield.
Smart Images
Figure CN222428014U_ABST
Abstract
Description
Technical Field
[0001] The utility model belongs to the technical field of cyclodextrin production devices, and specifically relates to a methyl beta-cyclodextrin production device. Background Art
[0002] Methyl-beta-cyclodextrin is a cyclic oligosaccharide composed of glucose units. It is a white to light yellow solid powder at room temperature and pressure. It is soluble in water but difficult to dissolve in low-polarity ether or alcohol organic solvents. Due to the presence of a hydrophobic core, methyl-beta-cyclodextrin has a higher affinity for cholesterol and is widely used in the field of basic biochemical research.
[0003] The reaction of iodomethane and beta-cyclodextrin is a methylation reaction. During the reaction, iodomethane reacts with sodium to form sodium methyl iodide, and then sodium methyl iodide and beta-cyclodextrin undergo a substitution reaction to form methyl beta-cyclodextrin. Due to the influence of steric hindrance, in most cases the product is a mixture of methylated derivatives, which requires solution and precipitation separation before further purification. The existing reactor cannot complete the purification operation immediately after preparation during the production process of methyl beta-cyclodextrin, and independent equipment is required for separation and purification. Utility Model Content
[0004] In view of the above deficiencies in the prior art, the technical problem to be solved by the utility model is to provide a methyl beta-cyclodextrin production device to achieve continuous production of methyl beta-cyclodextrin and improve the production efficiency of methyl beta-cyclodextrin.
[0005] The technical solution adopted by the utility model to solve its technical problems is:
[0006] The utility model discloses a methyl beta-cyclodextrin production device, comprising a reactor, a cyclodextrin buffer tank and an auxiliary agent buffer tank, wherein the cyclodextrin buffer tank and the auxiliary agent buffer tank are respectively connected to a raw material inlet and an auxiliary agent inlet at the top of the reactor, an alcohol liquid inlet is arranged at the top of the reactor, a filter screen is arranged inside the reactor, a circular connecting piece is arranged around the filter screen, the bottom of the filter screen is connected to the bottom of the reactor through a bearing, a material discharge port and a liquid discharge port are arranged at the bottom of the reactor, the material discharge port is connected to the inside of the filter screen, the liquid discharge port is connected to the bottom of the reactor, a reflux port is arranged on the upper part of the side wall of the reactor, the liquid discharge port is connected to a solution buffer tank, the solution buffer tank is connected to the reflux port, the material discharge port is connected to a washing kettle, and the washing kettle is connected to a nanofilter.
[0007] in:
[0008] The cyclodextrin buffer tank is provided with a solvent inlet and a material inlet, and the auxiliary agent buffer tank is provided with an alkali solution inlet and an iodomethane inlet.
[0009] The raw material inlet and the auxiliary agent inlet both penetrate the top of the reactor and extend to the upper inner part of the reactor. The height of the bottom end of the auxiliary agent inlet and the height of the bottom end of the raw material inlet are both lower than the position of the circular connecting piece.
[0010] The filter screen is a barrel-shaped structure, and the circular ring connector is fixedly arranged at the top edge of the filter screen.
[0011] The reactor is provided with a stirrer 1, which passes through the top of the reactor and is connected with a motor 1.
[0012] A circular groove is arranged on the inner wall of the reaction kettle, and the circular connecting piece is slidably arranged in the circular groove.
[0013] The reflux port is located on the side wall of the reactor above the annular groove, and the reflux port extends to the upper inner part of the filter screen.
[0014] The reactor is provided with a jacket outside, a water inlet is provided at the lower part of the jacket, and a water outlet is provided at the upper part of the jacket.
[0015] A fixing platform is arranged at the inner bottom of the reactor, and the top of the fixing platform is connected with a bearing.
[0016] A second stirrer is arranged inside the washing kettle, and the second stirrer passes through the top of the washing kettle and is connected to a second motor.
[0017] The beneficial effects of the utility model are:
[0018] The utility model can preliminarily purify the methyl beta-cyclodextrin after the reaction by improving the reactor, and can remove impurities in the methyl beta-cyclodextrin in the washing kettle and the nanofilter without affecting the yield of the methyl beta-cyclodextrin. The utility model pre-treats the reaction raw materials and the reaction aids respectively and then uniformly transports them to the reactor for reaction, which can improve the mixing degree and contact area of the raw materials, thereby quickly generating methyl beta-cyclodextrin. The excess solution is separated from the precipitated methyl beta-cyclodextrin by filtering in the reactor, thereby reducing the influence of other impurities in the solution on the methyl beta-cyclodextrin, and washing is performed multiple times in the washing kettle, and then relatively pure methyl beta-cyclodextrin can be obtained through nanofiltration. BRIEF DESCRIPTION OF THE DRAWINGS
[0019] Figure 1 It is a schematic diagram of the structure of the utility model;
[0020] Figure 2 It is a partial structural schematic diagram of the filter screen of the utility model;
[0021] Figure 3 yes Figure 1 Enlarged schematic diagram at point A in the middle.
[0022] In the figure: 1, reactor; 2, filter screen; 3, jacket; 4, liquid outlet; 5, material outlet; 6, additive outlet; 7, alcohol liquid inlet; 8, raw material inlet; 9, reflux outlet; 10, circular ring connector; 11, circular ring slot; 12, motor 1; 13, solution buffer tank; 14, fixed table; 15, bearing; 16, washing kettle; 17, nanofilter; 18, cyclodextrin buffer tank; 19, additive buffer tank;
[0023] 301, water inlet; 302, water outlet; 1201, agitator 1; 1601, motor 2; 1602, agitator 2; 1801, solvent inlet; 1802, material inlet; 1901, alkali solution inlet; 1902, iodomethane inlet 3. DETAILED DESCRIPTION
[0024] The embodiments of the present utility model are further described below in conjunction with the accompanying drawings.
[0025] Example 1
[0026] like Figure 1-3 As shown, the methyl beta-cyclodextrin production device described in the utility model includes a reactor 1, a cyclodextrin buffer tank 18 and an auxiliary agent buffer tank 19, the cyclodextrin buffer tank 18 and the auxiliary agent buffer tank 19 are respectively connected to the raw material inlet 8 and the auxiliary agent inlet 6 at the top of the reactor 1, the top of the reactor 1 is provided with an alcohol liquid inlet 7, the reactor 1 is provided with a filter screen 2 inside, the filter screen 2 is surrounded by a circular connecting piece 10, the bottom of the filter screen 2 is connected to the bottom of the reactor 1 through a bearing 15, the bottom of the reactor 1 is provided with a discharge port 5 and a liquid outlet 4, the discharge port 5 is connected to the inside of the filter screen 2, the liquid outlet 4 is connected to the bottom of the reactor 1, the upper part of the side wall of the reactor 1 is provided with a reflux port 9, the liquid outlet 4 is connected to the solution buffer tank 13, the solution buffer tank 13 is connected to the reflux port 9, the discharge port 5 is connected to the washing tank 16, and the washing tank 16 is connected to the nanofilter 17.
[0027] The filter screen 2 inside the reactor 1 can separate the methyl beta-cyclodextrin and the remaining solution after the reaction is completed to obtain a crude methyl beta-cyclodextrin. The liquid outlet 4 can transport the remaining solution to the solution buffer tank 13 for storage and then send it back to the reflux port 9 for re-filtration to ensure that the methyl beta-cyclodextrin can be completely separated. The crude methyl beta-cyclodextrin is transported to the washing kettle 16 for multiple washings to purify the crude methyl beta-cyclodextrin. The nanofilter 17 can further purify the methyl beta-cyclodextrin to obtain a relatively pure methyl beta-cyclodextrin.
[0028] The cyclodextrin buffer tank 18 is provided with a solvent inlet 1801 and a material inlet 1802 , and the auxiliary agent buffer tank 19 is provided with an alkali solution inlet 1901 and a methyl iodide inlet 1902 .
[0029] The raw material inlet 8 and the auxiliary agent inlet 6 both extend through the top of the reactor 1 to the upper inner part of the reactor 1 . The height of the bottom end of the auxiliary agent inlet 6 and the height of the bottom end of the raw material inlet 8 are both lower than the position of the annular connector 10 .
[0030] The filter screen 2 is a barrel-shaped structure, and the annular connector 10 is fixedly arranged at the top edge of the filter screen 2 .
[0031] A stirrer 1201 is arranged in the reactor 1, and the stirrer 1201 runs through the top of the reactor 1 and is connected to a motor 12.
[0032] The inner wall of the reactor 1 is provided with an annular groove 11, and the annular connector 10 is slidably arranged in the annular groove 11. The annular connector 10 slides in the annular groove 11, which can ensure the stability of the filter screen 2 and prevent friction with the inner wall of the reactor.
[0033] The reflux port 9 is located on the side wall of the reaction kettle 1 above the annular groove 11 , and the reflux port 9 extends to the upper inner part of the filter screen 2 .
[0034] A jacket 3 is disposed outside the reactor 1 , a water inlet 301 is disposed at the lower portion of the jacket 3 , and a water outlet 302 is disposed at the upper portion of the jacket 3 .
[0035] A fixing platform 14 is provided at the bottom of the inner side of the reactor 1, and the top of the fixing platform 14 is connected to a bearing 15. The fixing platform 14 can fix the bearing 15, thereby limiting the position of the filter screen 2.
[0036] A second agitator 1602 is provided inside the washing kettle 16 , and the second agitator 1602 passes through the top of the washing kettle 16 and is connected to a second motor 1601 .
[0037] Working principle and process:
[0038] Transport iodomethane and sodium hydroxide solution to the auxiliary agent buffer tank 19 for reaction, transport beta-cyclodextrin and organic solvent to the cyclodextrin buffer tank 18 for full dissolution, and then transport them together to the reactor 1 for reaction, turn on the motor 12 to drive the stirrer 1201 for stirring, open the water inlet 301 and the water outlet 302 to adjust the temperature in the reactor 1 for reaction, and after the reaction is completed, add ethanol to the reactor 1 through the alcohol liquid inlet 7 and stir continuously, the generated methyl beta-cyclodextrin is continuously precipitated, and the remaining solution is separated from the methyl beta-cyclodextrin by the filter screen 2, and the liquid outlet is opened. The remaining solution is transported to the solution buffer tank 13, and then the methyl beta-cyclodextrin is transported to the washing kettle 16 through the discharge port 5, and then the remaining solution in the solution buffer tank 13 is transported back to the reactor 1 through the reflux port 9 for multiple filtrations, and the remaining solution is recycled and reused, and the filtered methyl beta-cyclodextrin is transported to the washing kettle 16; the methyl beta-cyclodextrin is stirred and washed multiple times in the washing kettle 16, and after the washing is completed, the methyl beta-cyclodextrin solution is transported to the nanofilter 17, and the impurities that are more difficult to separate are discharged by nanofiltration to obtain a purer methyl beta-cyclodextrin.
Claims
1. A methyl beta-cyclodextrin production device, comprising a reactor (1), a cyclodextrin buffer tank (18) and an additive buffer tank (19), characterized in that: The cyclodextrin buffer tank (18) and the auxiliary agent buffer tank (19) are respectively connected to the raw material inlet (8) and the auxiliary agent inlet (6) at the top of the reactor (1). The top of the reactor (1) is provided with an alcohol liquid inlet (7). The reactor (1) is provided with a filter screen (2) inside. A circular connecting piece (10) is arranged around the filter screen (2). The bottom of the filter screen (2) is connected to the bottom of the reactor (1) through a bearing (15). The bottom of the reactor (1) is provided with a discharge port (5) and a liquid outlet (4). The discharge port (5) is connected to the inside of the filter screen (2). The liquid outlet (4) is connected to the bottom of the reactor (1). A reflux port (9) is provided on the upper part of the side wall of the reactor (1). The liquid outlet (4) is connected to a solution buffer tank (13). The solution buffer tank (13) is connected to the reflux port (9). The discharge port (5) is connected to a washing tank (16). The washing tank (16) is connected to a nanofilter (17).
2. The methyl beta-cyclodextrin production device according to claim 1, characterized in that: The cyclodextrin buffer tank (18) is provided with a solvent inlet (1801) and a material inlet (1802), and the auxiliary agent buffer tank (19) is provided with an alkali solution inlet (1901) and an iodomethane inlet (1902).
3. The methyl beta-cyclodextrin production device according to claim 1, characterized in that: The raw material inlet (8) and the auxiliary agent inlet (6) both extend through the top of the reaction kettle (1) to the upper inner part of the reaction kettle (1), and the height of the bottom end of the auxiliary agent inlet (6) and the height of the bottom end of the raw material inlet (8) are both lower than the position of the circular connecting piece (10).
4. The methyl beta-cyclodextrin production device according to claim 1, characterized in that: The filter screen (2) is a cylindrical structure, and the annular connecting piece (10) is fixedly arranged at the top edge of the filter screen (2).
5. The methyl beta-cyclodextrin production device according to claim 1, characterized in that: A stirrer 1 (1201) is arranged in the reaction kettle (1). The stirrer 1 (1201) runs through the top of the reaction kettle (1) and is connected to a motor 1 (12).
6. The methyl beta-cyclodextrin production device according to claim 1, characterized in that: A circular groove (11) is provided on the inner wall of the reaction kettle (1), and the circular connecting piece (10) is slidably arranged in the circular groove (11).
7. The methyl beta-cyclodextrin production device according to claim 6, characterized in that: The reflux port (9) is located on the side wall of the reaction kettle (1) above the annular groove (11), and the reflux port (9) extends to the upper inner part of the filter screen (2).
8. The methyl beta-cyclodextrin production device according to claim 1, characterized in that: A jacket (3) is arranged outside the reaction kettle (1); a water inlet (301) is arranged at the lower part of the jacket (3); and a water outlet (302) is arranged at the upper part of the jacket (3).
9. The methyl beta-cyclodextrin production device according to claim 1, characterized in that: A fixed platform (14) is provided at the bottom of the inner side of the reaction kettle (1), and the top of the fixed platform (14) is connected to a bearing (15).
10. The methyl beta-cyclodextrin production device according to claim 1, characterized in that: A second agitator (1602) is provided inside the washing kettle (16), and the second agitator (1602) passes through the top of the washing kettle (16) and is connected to a second motor (1601).