Tissue engineering skin preservation and transportation vessel

Abstract

The utility model relates to the technical field of tissue engineering product packaging and transportation, and particularly discloses a tissue engineering skin preservation and transportation vessel which comprises a vessel body, a vessel cover, a bearing frame and a pressing piece. An opening is formed in the upper end of the dish body; the dish cover covers the dish body and seals the opening. The bearing frame is installed in the dish body and provided with a bearing face for bearing the tissue engineering skin, and a plurality of fixing columns are arranged on the bearing face. The pressing piece is slidably arranged on the fixing column in a sleeving mode and used for pressing the tissue engineering skin on the bearing face. According to the utility model, the tissue engineering skin is fixed on the bearing frame through the pressing sheet and is immersed in the preservation liquid, so that the bad conditions of folding, adhesion, liquid level shaking, epidermal layer and corium layer structure separation and the like caused by liquid shaking in the transportation process are avoided, and the tissue engineering skin is always kept in an original placement state in the transportation process; and the risk of wrong use is reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of tissue engineering product packaging and transportation, in particular to a tissue engineering skin preservation and transportation dish. Background Art

[0002] For skin damaged by burns, inflammation and other factors, the traditional method of repair is autologous tissue transplantation. Although it can achieve therapeutic effects, it is at the expense of healthy autologous tissue and will cause many complications and additional damage. Since scientists first proposed the concept of "tissue engineering" in the 1980s, with the development of science and technology, tissue engineering skin with complete biological structure and function can be constructed through in vitro cultivation of stem cells in the patient's own tissues and transplanted into the human body to achieve the purpose of repairing the appearance and function of the skin.

[0003] Tissue-engineered skin is one of the medical applications of tissue engineering. It is a double-layer skin, including the epidermis and dermis. It is an autologous skin transplant substitute with biological activity and a structure similar to human skin, which is constructed by in vitro cultivation of allogeneic cells inoculated on a three-dimensional biological scaffold. Its obvious characteristics are: containing living cells, a double-layer structure of the epidermis and dermis, a hydrogel-like soft membrane and a certain toughness. Generally, after the production of tissue-engineered skin is completed, it will leave the incubator and be stored at a suitable temperature and transported to the hospital for treatment of patients.

[0004] At present, tissue-engineered skin is mostly preserved and transported in a simple way of immersing in preservation solution. For small areas of tissue-engineered skin, it can be directly immersed in the preservation solution in the bottle for preservation and transportation. However, for large areas of tissue-engineered skin, if it is not fixed in the preservation solution, it is easy to cause adverse consequences such as folding, adhesion, shaking out of the liquid surface, and separation of the epidermis and dermis structure during transportation due to the vibration of the liquid. In addition, tissue-engineered skin that is not fixed will be folded during transportation and is no longer in its original placement state. It is difficult to distinguish the epidermis and dermis, which increases the risk of incorrect use. Utility Model Content

[0005] In view of the defects in the prior art, the utility model provides a tissue engineering skin preservation and transportation dish to solve the problem that the tissue engineering skin is immersed in the preservation liquid and is not fixed, which may cause folding, adhesion, shaking out of the liquid surface, separation of the epidermis and dermis structure due to the vibration of the liquid during transportation, and it is difficult to distinguish between the epidermis and dermis, leading to the risk of incorrect use.

[0006] The specific technical solutions are as follows:

[0007] A tissue engineering skin preservation and transportation vessel, comprising:

[0008] A dish body, wherein an opening is provided at an upper end of the dish body;

[0009] A dish cover, which covers the dish body and seals the opening;

[0010] A support frame, which is installed in the dish body and has a support surface for supporting the tissue engineered skin, and a plurality of fixing columns are arranged on the support surface; and

[0011] A pressing sheet is slidably mounted on the fixing column and is an elastic sheet used for pressing the tissue engineering skin on the bearing surface.

[0012] In one embodiment, the dish body includes an outer dish and an inner dish disposed in the outer dish, and the outer dish and the inner dish are connected; a receiving cavity is formed between the outer wall of the inner dish and the inner wall of the outer dish, and the receiving cavity is provided with a filler.

[0013] In one embodiment, the inner dish further comprises an inner dish cover, which is buckled onto the inner dish and seals the inner dish opening.

[0014] In one embodiment, after the dish cover covers the opening of the outer dish, the bottom wall of the dish cover contacts the top wall of the inner dish cover.

[0015] In one of the embodiments, it further comprises a mesh plate, which is slidably mounted on the fixing column and disposed on the pressing sheet; the mesh plate is provided with a mesh through which liquid can pass but tissue-engineered skin cannot pass.

[0016] In one of the embodiments, a filler is provided between the grid plate and the inner dish cover.

[0017] Beneficial effects of the utility model:

[0018] The above-mentioned tissue-engineered skin storage and transportation dish, by providing a carrier for carrying the tissue-engineered skin in the dish body and a pressing sheet for fixing the tissue-engineered skin in the dish body, the tissue-engineered skin will not fold, adhere, shake out of the liquid surface, separate the epidermis and dermis structure, etc. due to the vibration of the liquid. In addition, the tissue-engineered skin is fixed during transportation and will not turn over, and the original placement state is always retained, which effectively distinguishes the epidermis and dermis, and reduces the risk of incorrect use. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the specific implementation of the utility model, the following will briefly introduce the drawings required for use in the specific implementation. In all the drawings, each element or part is not necessarily drawn according to the actual scale.

[0020] Figure 1 This is a schematic diagram of the structure of the tissue engineering skin storage and transportation dish of the utility model;

[0021] Figure 2 Schematic diagram of the structure after the grid and the support frame are assembled

[0022] Figure 3 The structure diagram of the dish body of the utility model is shown in FIG.

[0023] Reference numerals:

[0024] 1-dish body, 11-outer dish, 12-inner dish, 13-accommodating cavity, 14-filler, 2-dish cover,

[0025] 21-inner dish cover, 3-carrying frame, 31-carrying surface, 32-fixing column, 4-pressing sheet, 5-grid plate,

[0026] 51-mesh, 6-tissue engineered skin. DETAILED DESCRIPTION

[0027] The following embodiments of the technical solution of the utility model are described in detail in conjunction with the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solution of the utility model, and are therefore only used as examples, and cannot be used to limit the protection scope of the utility model.

[0028] See also Figure 1 and Figure 3 In one embodiment, a tissue engineering skin storage and transportation dish includes: a dish body 1, a dish cover 2, a carrier frame 3 and a pressing sheet 4.

[0029] In one embodiment, the upper end of the dish body 1 is provided with an opening. In order to prevent the storage liquid in the dish body from being directly subjected to force when the dish body 1 is subjected to external force, the dish body 1 is configured as an outer dish 11 and an inner dish 12, and the inner dish 12 is arranged in the outer dish 11. In this way, a receiving chamber 13 is formed between the outer wall of the inner dish 12 and the inner wall of the outer dish 11. When subjected to external force, the receiving chamber 13 is subjected to the external force, which can alleviate the stress state of the inner dish 12. Further, the receiving chamber 13 is filled with a filler 14, which plays a buffering role, further weakens the force on the inner dish 12, thereby weakening the vibration of the storage liquid stored in the inner dish 12. Further, a plurality of connecting holes are provided between the outer dish 11 and the inner dish 12, and the outer dish 11 and the inner dish 12 are connected. Preferably, the filler 14 is a sponge, which is soft and porous, and not only plays a shock-absorbing and buffering role, but also has a strong ability to absorb and store liquid.

[0030] On the basis of the above embodiment, in order to facilitate relevant personnel to observe the tissue engineered skin 6, the dish body 1 can be made of a transparent material.

[0031] In one embodiment, the tops of the outer dish 11 and the inner dish 12 are both open, and a dish cover 2 is provided to cover the outer dish 11 and seal the opening; an inner dish cover 21 is provided to cover the inner dish 12 and seal the opening of the inner dish 12.

[0032] The outer wall of the outer dish 11 is provided with an outer thread, and the inner wall of the dish cover 2 is provided with an inner thread matching the outer thread. Through the thread matching, the dish cover 2 is screwed on / off the outer dish 11, so that the dish cover 2 can be detachably installed on the outer dish 11 and seal the opening. Similarly, the inner dish 12 and the inner dish cover 21 are correspondingly arranged so that the inner dish cover 21 covers the inner dish 12 and seals the opening of the inner dish 12.

[0033] On the basis of the above embodiment, in order to reduce the gap between the dish cover 2 and the inner dish cover 21 and prevent the inner dish cover 21 from separating from the inner dish 12, after the dish cover 2 covers the opening of the outer dish 11, the bottom wall of the dish cover 2 contacts the top wall of the inner dish cover 21.

[0034] See also Figure 2 In one embodiment, the carrier 3 is installed in the inner dish 12, and a bearing surface 31 for bearing the tissue engineering skin 6 is provided on the end surface of the carrier 3 facing the opening of the inner dish 12, and a plurality of fixing posts 32 are provided on the bearing surface 31. A layer of 3M glue is covered on the end surface of the carrier 3 facing the bottom of the inner dish 12, and the carrier 3 is fixed to the bottom of the inner dish 12 by the 3M glue. The carrier 3 is provided to prevent the tissue engineering skin 6 from being directly placed in the inner dish 12, and the tissue engineering skin 6 reduces the direct external force from the bottom of the dish body 1.

[0035] In one embodiment, the pressing sheet 4 can be slidably sleeved on the fixed column 32, and the pressing sheet 4 is used to press the tissue engineering skin 6 placed on the bearing surface 31. Corresponding to the position of the fixed column 32, a through hole is correspondingly provided on the pressing sheet 4. Through the cooperation between the hole and the column, the pressing sheet 4 can move along the axis of the fixed column 32, and the pressing sheet 4 rotates around the fixed column 32, so that the pressing sheet 4 moves to a suitable position, so that the tissue engineering skin 6 is pressed and fixed on the bearing surface 31. Even if the preservation liquid is vibrated by external force, the pressing sheet 4 fixes the tissue engineering skin 6 on the bearing surface 31, thereby avoiding folding, adhesion, shaking out of the liquid surface, separation of the epidermis / dermis structure, etc. The tissue engineering skin 6 is always in the original placement state during transportation, and it is very easy to separate the epidermis and dermis, reducing the risk of incorrect use.

[0036] On the basis of the above-mentioned embodiment, in order to adapt to tissue engineering skin 6 of different areas, pressing sheets 4 of various lengths are prepared, and pressing sheets 4 of corresponding lengths are selected according to actual needs.

[0037] On the basis of the above embodiment, the pressing sheet 4 is an elastic sheet, which has high tensile strength and fatigue resistance, and returns to its original shape after the external force is removed, and the pressing sheet 4 ensures that the tissue engineering skin 6 is fixed on the bearing surface 31. With this structure, the pressing sheet 4 has a large contact area with the skin, and the pressing sheet 4 presses the tissue engineering skin 6 more tightly without damaging the tissue engineering skin 6.

[0038] In one embodiment, a grid plate 5 is further included, and a through hole is correspondingly provided on the grid plate 5 correspondingly corresponding to the position of the fixed column 32. Through the cooperation between the hole and the column, the grid plate 5 can move along the axis of the fixed column 32. The grid plate 5 is arranged on the top of the pressing plate 4. The grid plate 5 is provided with a grid 51 through which liquid can pass, but the tissue engineering skin 6 cannot pass. With this structure, the grid plate 5 fixes the pressing plate 4 on the fixed column 32, and the pressing plate 4 is not easy to move upward on the fixed column 32, so as to ensure that the pressing plate 4 is tightly pressed against the tissue engineering skin 6. At the same time, the grid plate 5 divides the inner dish 12 into two layers, upper and lower, to ensure that the tissue engineering skin 6 is immersed in the preservation liquid.

[0039] Based on the above embodiment, a filler 14 is provided between the grid plate 5 and the inner dish cover 21. The filler 14 reduces the external force from the dish cover 2 to the tissue engineering skin 6; and the filler 14 floats on the preservation solution, and when the dish body 1 is subjected to external force, the oscillation of the preservation solution can be quickly and steadily.

[0040] When in use, the dish cover 2 and the inner dish cover 21 are removed from the dish body 1, and the carrier 3 is installed and taken out and placed on the work surface. According to the area and shape of the tissue engineered skin 6, a suitable pressing sheet 4 is selected, and the pressing sheet 4 is installed on the fixed column 32. The tissue engineered skin 6 is placed on the bearing surface 31, and the pressing sheet 4 is rotated to press the pressing sheet 4 on the tissue engineered skin 6, and the dermis and epidermis of the tissue engineered skin 6 are marked; the grid plate 5 is installed at a suitable position on the fixed column 32, and the carrier 3 is placed in the inner dish 12, and the filler 14 is placed in the accommodating cavity 13, and the preservation liquid is added, and the filler 14 is placed on the grid plate 5, and the preservation liquid is added again until the preservation liquid is flush with the opening of the inner dish 12, and the inner dish cover 21 is covered, and the dish cover 2 is covered. If necessary, a PE bag is installed outside the dish body 1 and vacuumed.

[0041] Beneficial effects of the utility model:

[0042] The above-mentioned tissue engineering skin preservation and transportation dish can effectively prevent external forces from acting on the dish body by setting an outer dish 11 and an inner dish 12 in the dish body 1, and filling a filler 14 between the outer dish 11 and the inner dish 12; a bearing frame for carrying the tissue engineering skin 6 is provided in the inner dish, and a pressing sheet for fixing the tissue engineering skin 6 is provided in the inner dish 12, so that the tissue engineering skin 6 will not cause adverse consequences such as folding, adhesion, shaking out of the liquid surface, and separation of the epidermal structure due to the vibration of the liquid. In addition, the tissue engineering skin 6 is fixed during transportation and will not flip, and the original placement state is always retained, which effectively distinguishes the epidermal layer and reduces the risk of incorrect use. A grid plate 5 is provided in the inner dish 12, and the grid plate 5 fixes the pressing sheet 4 on the fixed column 32 to ensure that the tissue engineering skin 6 is immersed in the preservation liquid. Filling the filling material 14 between the grid plate 5 and the inner dish cover 21 can quickly and smoothly oscillate the preservation liquid.

[0043] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein by equivalents. These modifications or replacements do not deviate the essence of the corresponding technical solutions from the scope of the technical solutions of the embodiments of the present invention, and they should all be included in the scope of the claims and specification of the present invention.

Claims

1. A tissue engineering skin storage and transportation vessel, characterized in that: include: A dish body, wherein an opening is provided at an upper end of the dish body; A dish cover, which covers the dish body and seals the opening; A support frame, which is installed in the dish body and has a support surface for supporting the tissue engineered skin, and a plurality of fixing columns are arranged on the support surface; and A pressing sheet is slidably mounted on the fixing column and is an elastic sheet used for pressing the tissue engineering skin on the bearing surface.

2. The tissue engineering skin storage and transportation dish according to claim 1, characterized in that: The dish body comprises an outer dish and an inner dish arranged in the outer dish, and the outer dish and the inner dish are communicated with each other; an accommodating cavity is formed between the outer side wall of the inner dish and the inner side wall of the outer dish, and the accommodating cavity is provided with a filler.

3. The tissue engineering skin storage and transportation dish according to claim 2, characterized in that: The inner dish further comprises an inner dish cover, which is buckled on the inner dish and seals the inner dish opening.

4. The tissue engineering skin storage and transportation dish according to claim 3, characterized in that: After the dish cover covers the opening of the outer dish, the bottom wall of the dish cover contacts the top wall of the inner dish cover.

5. The tissue engineering skin storage and transportation dish according to claim 4, characterized in that: It also includes a grid plate, which can be slidably sleeved on the fixed column and arranged on the pressing sheet; the grid plate is provided with a grid through which liquid can pass but tissue engineering skin cannot pass.

6. The tissue engineering skin storage and transportation dish according to claim 5, characterized in that: A filler is arranged between the grid plate and the inner dish cover.

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