Catalytic hydrogenation reaction device for ensafetine compound

Abstract

The utility model relates to the technical field of medicine production, and discloses a catalytic hydrogenation reaction device for an empenFenton compound. The catalytic hydrogenation reaction device comprises a fixing plate, a supporting frame is fixedly mounted on the left side of the fixing plate, a supporting plate is fixedly mounted above the supporting frame, a stepping motor is fixedly mounted above the supporting plate, a connecting shaft is movably mounted above the fixing plate, and the connecting shaft is movably connected with the left side of the fixing plate and the right side of the fixing plate. A fixing frame is fixedly installed on the right side of the connecting shaft, a reaction kettle is fixedly installed in the fixing frame, after the reaction kettle is filled with a reaction solution, hydrogen is added into the reaction kettle through a one-way valve by using gas conveying equipment such as a gas pump, and in the continuous hydrogen injection process, the pressure in the reaction kettle is increased; therefore, a reaction solution at the bottom in the reaction kettle is discharged out of the reaction kettle from the pressure valve, and air in the reaction kettle can be completely discharged, so that the air is prevented from influencing the catalytic effect of hydrogen.

Description

Technical Field

[0001] The utility model relates to the technical field of drug production, in particular to a catalytic hydrogenation reaction device for an encefantine compound. Background Art

[0002] Ensefentin is an inhaled dual-target PDE 3 / 4 inhibitor of phosphodiesterase protein. Its dual inhibition mechanism enables it to achieve both bronchodilatory and anti-inflammatory effects with a single compound. Given its efficacy in treating respiratory disorders, Ensefentin is usually administered by inhalation.

[0003] The existing referenceable Chinese utility model patent with announcement number: CN219559563U discloses a catalytic hydrogenation reaction device, which aims to solve the problem that the added hydrogen cannot be quickly dissolved when reacting with the liquid, which reduces the reaction speed and affects the processing progress. The key points of its technical solution are: a catalytic hydrogenation reaction device, including a tank body, a support leg is arranged on the outer side of the lower end of the tank body, a connecting plate is fixedly installed in the middle of the supporting leg, a driving device is arranged on the upper end of the connecting plate, a cylinder is movably connected inside the tank body, the cylinder body and the driving device are fixedly connected, a feed pipe is fixedly installed on the right side of the upper end of the cylinder body, a bracket is fixedly installed on the upper end of the cylinder body, and a rotating device is arranged on the upper end of the bracket. The utility model has multiple exhaust agitation pipes arranged from top to bottom in the cylinder body, which can be discharged at different depths of the liquid, so that the liquid at different depths reacts with the hydrogen faster, and at the same time, the rotation of the exhaust agitation pipe can stir the liquid and the discharged hydrogen to increase the reaction speed.

[0004] The existing catalytic hydrogenation reaction device only mixes hydrogen with the reaction solution by stirring. This method has poor mixing efficiency and a small contact area between the solution and hydrogen, which affects the reaction speed. Since the density of hydrogen is lower than that of air, the existing hydrogenation reaction device cannot fill the reactor with hydrogen, and some air will remain inside the reactor, affecting the catalytic effect of hydrogen. Utility Model Content

[0005] 1. Technical issues to be resolved

[0006] In view of the deficiencies in the prior art, the utility model provides a catalytic hydrogenation reaction device for an ensephentin compound, which has the advantages of being able to completely exhaust the air inside the reactor and improving the catalytic effect of hydrogen, thereby solving the above-mentioned technical problems.

[0007] (II) Technical solution

[0008] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a catalytic hydrogenation reaction device for ensefentin compounds, comprising: a fixed plate, a support frame is fixedly installed on the left side of the fixed plate, a support plate is fixedly installed above the support frame, a stepping motor is fixedly installed above the support plate, a connecting shaft is movably installed above the fixed plate, a fixed frame is fixedly installed on the right side of the connecting shaft, a reactor is fixedly installed inside the fixed frame, an end cover is movably installed on the upper end of the reactor, a one-way valve is inserted inside the end cover, a baffle is fixedly installed inside the reactor, a pressure valve is inserted at the bottom end of the reactor, and a bottom plate is fixedly installed below the fixed plate; the one-way valve can facilitate the addition of reactants into the reactor.

[0009] As the preferred technical solution of the utility model, the fixed plate is installed on the left and right sides of the top surface of the base plate symmetrically with the center of the reactor as the reference, and the support frame is installed on the left and right sides of the fixed plate on the left and right sides of the base plate respectively with the center of the base plate as the reference; the fixed plate can support the connecting shaft.

[0010] As a preferred technical solution of the utility model, the connecting shaft is installed on the left and right sides of the fixing frame in a mirror-symmetrical manner with the center of the fixing frame as a reference, a rotating connection is formed between the connecting shaft and the fixing plate, and a fixed connection is formed between the fixing frame and the reactor; the connecting shaft can allow the fixing frame to rotate while limiting the position of the fixing frame.

[0011] As the preferred technical solution of the utility model, the stepper motor is installed above the left and right support plates in a mirror-symmetrical manner with the center of the fixed frame as the reference, and the rotating shaft of the stepper motor is fixedly connected with the connecting shaft by interlacing; the stepper motor can drive the connecting shaft to rotate.

[0012] As a preferred technical solution of the utility model, the reactor is funnel-shaped, the top of the reactor is movably connected to the end cover through a threaded structure, and the one-way valve passes through the end cover; the reactor can receive the reaction solution.

[0013] As a preferred technical solution of the utility model, the baffles are installed on the upper and lower sides of the reactor in a group of two with the center of the reactor as the reference, and the baffles in the same group are mirror-symmetrical front and back. The top of the baffle above the reactor does not contact the inner wall of the reactor, and the lower end of the baffle below the reactor does not contact the inner wall of the reactor; the baffles can increase the travel of hydrogen from bottom to top.

[0014] As a preferred technical solution of the utility model, the passing direction of the pressure valve is vertically downward, and the pressure valve vertically penetrates the bottom surface of the reactor; the pressure valve can discharge the solution or gas to the outside when the pressure inside the reactor is too high.

[0015] Compared with the prior art, the utility model provides a catalytic hydrogenation reaction device for enzefentin compounds, which has the following beneficial effects:

[0016] 1. The utility model sets a pressure valve and adds a reaction solution to the interior of the reactor through a one-way valve. After the reaction solution fills the interior of the reactor, the pressure inside the reactor increases. Since the passage direction of the pressure valve is vertically downward, when the pressure inside the reactor exceeds the bearing limit of the pressure valve, the reaction solution will be discharged through the pressure valve. After that, a gas delivery device such as an air pump is used to add hydrogen to the interior of the reactor through the one-way valve. During the continuous injection of hydrogen, the pressure inside the reactor increases, so that the reaction solution at the bottom of the reactor is discharged from the reactor through the pressure valve. This method can completely exclude the air inside the reactor, thereby preventing the air from affecting the catalytic effect of hydrogen.

[0017] 2. The utility model is provided with a stepper motor. After the reaction solution and hydrogen are added, the stepper motor will rotate 180 degrees clockwise and counterclockwise alternately at the same time interval. Since the hydrogen will stay at the top of the reactor and the reactor is funnel-shaped, after the reactor rotates 180 degrees, the hydrogen at the top of the reactor will be below the reaction solution. Under the influence of air pressure, the hydrogen will move upward, pass through the thinnest part of the reactor, move to the upper end of the reactor in the form of bubbles, and move to the upper end of the reactor in a "Z" shape under the obstruction of the baffle. After passing through the thinnest part of the reactor, the reaction solution will move to the lowest end of the reactor in a "Z" shape under the obstruction of the baffle. In this way, the contact area between the reaction solution and the hydrogen is increased, so as to improve the catalytic effect of the hydrogen. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0019] Figure 2 This is a schematic diagram of the connection structure between the fixing frame and the stepping motor of the utility model;

[0020] Figure 3 This is a schematic diagram of the connection structure between the reactor and the fixed frame of the utility model;

[0021] Figure 4 This is a schematic diagram of the cross-sectional structure of the reaction kettle of the utility model;

[0022] Among them: 1. fixed plate; 11. support frame; 12. support plate; 13. stepper motor; 14. connecting shaft; 15. fixed frame; 16. reaction kettle; 17. end cover; 18. one-way valve; 19. baffle; 110. pressure valve; 111. bottom plate. DETAILED DESCRIPTION

[0023] The following is a further detailed description of the implementation of the present invention in conjunction with the accompanying drawings and examples. The following examples are used to illustrate the present invention, but cannot be used to limit the scope of the present invention.

[0024] In the description of the present invention, unless otherwise specified, "multiple" means two or more; the terms "upper", "lower", "left", "right", "inner", "outer", "front end", "rear end", "head", "tail" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, which is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", "third" and the like are only used for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0025] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "connected" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0026] See also Figure 1 - Figure 4 In this embodiment, a catalytic hydrogenation reaction device for an ensefentin compound includes: a fixed plate 1, a support frame 11 is fixedly installed on the left side of the fixed plate 1, a support plate 12 is fixedly installed above the support frame 11, a stepping motor 13 is fixedly installed above the support plate 12, a connecting shaft 14 is movably installed above the fixed plate 1, a fixing frame 15 is fixedly installed on the right side of the connecting shaft 14, a reactor 16 is fixedly installed inside the fixing frame 15, an end cover 17 is movably installed on the upper end of the reactor 16, a one-way valve 18 is inserted inside the end cover 17, a baffle 19 is fixedly installed inside the reactor 16, a pressure valve 110 is inserted at the bottom end of the reactor 16, and a bottom plate 111 is fixedly installed below the fixed plate 1.

[0027] The fixed plate 1 is installed on the left and right sides of the top surface of the bottom plate 111 symmetrically with the center of the reactor 16 as the reference, and the support frame 11 is installed on the left and right sides of the fixed plate 1 on the left and right sides of the bottom plate 111 with mirror symmetry with the center of the bottom plate 111 as the reference.

[0028] The connecting shaft 14 is installed on the left and right sides of the fixing frame 15 in a mirror-symmetrical manner with the center of the fixing frame 15 as the reference. The connecting shaft 14 and the fixing plate 1 form a rotating connection, and the fixing frame 15 and the reaction kettle 16 form a fixed connection.

[0029] The stepper motor 13 is installed above the left and right support plates 12 in a mirror-symmetrical manner with the center of the fixing frame 15 as a reference, and the rotating shaft of the stepper motor 13 is fixedly connected with the connecting shaft 14 by interlacing.

[0030] The reaction kettle 16 is funnel-shaped, and the top of the reaction kettle 16 is movably connected to the end cover 17 through a threaded structure, and the one-way valve 18 passes through the end cover 17 .

[0031] The baffles 19 are installed on the upper and lower sides of the reactor 16 in a group of two with the center of the reactor 16 as the reference, and the baffles 19 in the same group are mirror-symmetrical front to back. The top of the baffle 19 above the reactor 16 does not contact the inner wall of the reactor 16, and the bottom of the baffle 19 below the reactor 16 does not contact the inner wall of the reactor 16.

[0032] The passing direction of the pressure valve 110 is vertically downward, and the pressure valve 110 vertically passes through the bottom surface of the reaction kettle 16 .

[0033] Specifically, the fixed plate 1 can support the connecting shaft 14, the support frame 11 can support the support plate 12, the support plate 12 can support the stepper motor 13, the stepper motor 13 can drive the connecting shaft 14 to rotate, the connecting shaft 14 can allow the fixed frame 15 to rotate while limiting the position of the fixed frame 15, the fixed frame 15 can drive the reactor 16 to rotate, the reactor 16 can receive the reaction solution, the end cover 17 can facilitate the cleaning of the reactor 16, the one-way valve 18 can facilitate the addition of reactants to the inside of the reactor 16, the baffle 19 can increase the stroke of hydrogen moving from bottom to top, the pressure valve 110 can discharge the solution or gas to the outside when the internal pressure of the reactor 16 is too high, and the bottom plate 111 can support the fixed plate 1.

[0034] During use, the pressure valve 110 needs to be connected to the hose before adding the reaction raw materials, and then the reaction solution is added to the reactor 16 through the one-way valve 18. After the reaction solution fills the reactor 16, the pressure inside the reactor 16 increases. Since the passing direction of the pressure valve 110 is vertically downward, when the pressure inside the reactor 16 exceeds the bearing limit of the pressure valve 110, the reaction solution will be discharged through the pressure valve 110. Then, a gas delivery device such as an air pump is used to add hydrogen to the reactor 16 through the one-way valve 18. During the continuous injection of hydrogen, the pressure inside the reactor 16 increases, so that the reaction solution at the bottom of the reactor 16 is discharged from the reactor 16 through the pressure valve 110. This method can completely exclude the air inside the reactor 16, thereby preventing the air from affecting the catalytic effect of the hydrogen. After the reaction solution and hydrogen are added, the stepper motor 13 will rotate 180 degrees clockwise and counterclockwise alternately at the same time interval. Since the hydrogen will stay at the top of the reactor 16, and the reactor 16 is funnel-shaped, after the reactor 16 rotates 180 degrees, the hydrogen at the top of the reactor 16 will be below the reaction solution. Under the influence of air pressure, the hydrogen will move upward, pass through the thinnest part of the reactor 16, and move to the upper end of the reactor 16 in the form of bubbles, and move to the upper end of the reactor 16 in a "Z" shape under the obstruction of the baffle 19. After passing through the thinnest part of the reactor 16, the reaction solution will move to the bottom of the reactor 16 in a "Z" shape under the obstruction of the baffle 19. In this way, the contact area between the reaction solution and the hydrogen is increased to improve the catalytic effect of the hydrogen.

[0035] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A catalytic hydrogenation reaction device for an enzefentin compound, characterized in that: include: A fixed plate (1), a support frame (11) is fixedly installed on the left side of the fixed plate (1), a support plate (12) is fixedly installed above the support frame (11), a stepping motor (13) is fixedly installed above the support plate (12), a connecting shaft (14) is movably installed above the fixed plate (1), a fixed frame (15) is fixedly installed on the right side of the connecting shaft (14), a reaction kettle (16) is fixedly installed inside the fixed frame (15), an end cover (17) is movably installed on the upper end of the reaction kettle (16), a one-way valve (18) is inserted inside the end cover (17), a baffle (19) is fixedly installed inside the reaction kettle (16), a pressure valve (110) is inserted at the bottom end of the reaction kettle (16), and a bottom plate (111) is fixedly installed below the fixed plate (1).

2. The catalytic hydrogenation reaction device of an encefantine compound according to claim 1, characterized in that: The fixed plate (1) is symmetrically mounted on the left and right sides of the top surface of the bottom plate (111) with the center of the reaction kettle (16) as a reference, and the support frame (11) is mirror-symmetrically mounted on the left and right sides of the fixed plate (1) on the left and right sides of the bottom plate (111) with the center of the bottom plate (111) as a reference.

3. The catalytic hydrogenation reaction device of an ensefentin compound according to claim 1, characterized in that: The connecting shaft (14) is mounted on the left and right sides of the fixing frame (15) in a mirror-symmetrical manner with the center of the fixing frame (15) as a reference. The connecting shaft (14) and the fixing plate (1) form a rotational connection, and the fixing frame (15) and the reaction kettle (16) form a fixed connection.

4. The catalytic hydrogenation reaction device of an encefantine compound according to claim 1, characterized in that: The stepper motor (13) is installed above the left and right support plates (12) in a mirror-symmetrical manner with the center of the fixing frame (15) as a reference, and the rotating shaft of the stepper motor (13) is fixedly connected to the connecting shaft (14) by means of insertion.

5. The catalytic hydrogenation reaction device of an ensephentin compound according to claim 1, characterized in that: The reaction kettle (16) is funnel-shaped, and the top end of the reaction kettle (16) is movably connected to the end cover (17) via a threaded structure, and the one-way valve (18) passes through the end cover (17).

6. The catalytic hydrogenation reaction device of an encefantine compound according to claim 1, characterized in that: The baffles (19) are mounted on the upper and lower sides of the reactor (16) in a group of two with the center of the reactor (16) as a reference, and the baffles (19) in the same group are mirror-symmetrical in front and back directions. The top of the baffle (19) above the reactor (16) does not contact the inner wall of the reactor (16), and the bottom of the baffle (19) below the reactor (16) does not contact the inner wall of the reactor (16).

7. The catalytic hydrogenation reaction device of an encefantine compound according to claim 1, characterized in that: The passing direction of the pressure valve (110) is vertically downward, and the pressure valve (110) vertically passes through the bottom surface of the reaction kettle (16).

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