Novel ultrafilter for biological manufacturing

Abstract

The utility model provides a novel ultrafilter for biological manufacturing, which comprises a cavity, an air inlet pipe, a fan, a first gate valve, an ultrafiltration module, a liquid outlet pipe, a first pump body, a second gate valve, a reverse cleaning pipe, a second pump body, a third gate valve, a purification tank, a chlorination pump body and a controller, a dynamic air flow is conveyed into a cavity through a fan which alternately operates at different powers in the reverse cleaning and overwashing process, so that a liquid flow in the cavity forms dynamic fluctuation, and a fluorine-containing solution can be fully cleaned and sterilized in the cavity and an ultrafiltration module in a dynamic manner; the liquid flow is driven by the air flow to realize dynamic fluctuation, so that the fluorine-containing solution can be in full contact, the reverse cleaning action is realized in a more efficient manner, the cleaning performance of the ultrafilter is improved, and the subsequent ultrafiltration processing performance of biological manufacturing is influenced.

Description

Technical Field

[0001] The utility model relates to the technical field of ultrafiltration machines, in particular to a novel ultrafiltration machine used for biomanufacturing. Background Art

[0002] Ultrafiltration technology has a wide range of applications in the field of biomanufacturing, and is used to separate and purify biological molecules such as proteins, cells, DNA, RNA, etc. in biological products. The design and development of new ultrafiltration machines usually consider the following aspects:

[0003] Membrane material selection: The key to new ultrafiltration machines is the selection of membrane materials. Common membrane materials include polyamide, polysulfide, polycarbonate, etc. In recent years, the development of nanotechnology has made nanopore membrane materials possible, which can achieve more efficient separation and higher permeability.

[0004] Modular design: New ultrafiltration machines usually adopt modular design, which allows users to flexibly assemble and disassemble different components according to their needs. Such a design can improve the applicability and flexibility of the equipment while reducing the cost of maintenance and replacement of parts.

[0005] Automatic control: Modern ultrafiltration machines are usually equipped with advanced automatic control systems, which can realize intelligent operation and monitoring. Through sensors and feedback control systems, the pressure, flow, temperature and other parameters in the ultrafiltration process can be monitored and adjusted in real time to ensure the quality and stable output of the product.

[0006] Energy saving and environmental protection: The design of new ultrafiltration machines also pays more and more attention to energy saving and environmental protection. The use of efficient energy recovery devices and low-energy consumption working modes can reduce energy consumption and operating costs while reducing the impact on the environment.

[0007] Cleaning and disinfection: The ultrafiltration membrane needs to be cleaned and disinfected after a period of use to ensure its separation performance and service life. New ultrafiltration machines are usually equipped with automated cleaning systems that can achieve efficient and thorough cleaning and disinfection, thereby reducing the cost and risk of manual operation.

[0008] However, when the existing ultrafiltration machines are used in the production process of biomanufacturing, the ultrafiltration module and the purification cavity cannot be fully cleaned and disinfected by only using the reverse-transported liquid flow with chlorine added during reverse cleaning of the pipeline, thereby reducing the cleaning performance of the ultrafiltration machine and affecting the subsequent ultrafiltration processing performance of biomanufacturing. Utility Model Content

[0009] In view of this, the technical problem to be solved by the utility model is: how to provide a new type of ultrafiltration machine for biomanufacturing to deliver a dynamic airflow to the interior of the cavity during backwashing through a fan operating alternately at different powers to form a dynamic fluctuation of the liquid flow inside the cavity, so that the fluorine-containing solution can be fully cleaned and sterilized in the cavity and the ultrafiltration module in a dynamic manner.

[0010] To achieve the above-mentioned purpose, the utility model proposes a novel ultrafiltration machine for biomanufacturing, which includes a cavity, an air inlet pipe, a fan, a first gate valve, an ultrafiltration module, a liquid outlet pipe, a first pump body, a second gate valve, a reverse cleaning pipe, a second pump body, a third gate valve, a purification tank, a chlorination pump body and a controller;

[0011] A plurality of the ultrafiltration modules are arranged inside the cavity, and the cavity is used to contain a solution that needs to be purified and filtered;

[0012] The air inlet pipe is arranged at the bottom of the cavity, the air inlet pipe is arranged along the width direction of the cavity, a plurality of air vents are arranged on the air inlet pipe, the fan and the first gate valve are respectively connected to the pipeline of the air inlet pipe, the fan is connected to the controller, and the airflow provided by the operation of the fan enters the interior of the cavity through the air inlet pipe;

[0013] The liquid outlet pipe is arranged on the top of the ultrafiltration module, the first pump body and the second gate valve are connected to the pipeline of the liquid outlet pipe, the end of the liquid outlet pipe is connected to the purification tank, and the first pump body is connected to the controller;

[0014] The reverse cleaning pipe is connected to the bottom of the purification tank, the pipeline of the reverse cleaning pipe is connected to the second pump body, the third gate valve and the chlorination pump body, and the chlorination pump body and the second pump body are connected to the controller;

[0015] The controller is configured to drive the second pump body and the chlorination pump body to start working when the first pump body stops working, and control the fan to alternately operate at the maximum power of the fan and the minimum power of the fan according to a preset time period.

[0016] Further, the preset time period is the duration during which the fan operates alternately at the maximum power of the fan or the minimum power of the fan.

[0017] Furthermore, a drain pipe is arranged at the bottom of the cavity, and an overflow pipe is arranged at the top of the cavity.

[0018] Furthermore, the plurality of ventilation holes are arranged at intervals along the length direction of the air inlet pipe.

[0019] Compared with the related art, the utility model proposes a new type of ultrafiltration machine for biomanufacturing, which has the beneficial effect of: by using fans running alternately at different powers to deliver dynamic airflow to the inside of the cavity during backwashing, the liquid flow inside the cavity forms dynamic fluctuations, so that the fluorine-containing solution can be fully cleaned and sterilized in the cavity and the ultrafiltration module in a dynamic manner. The liquid flow realizes dynamic fluctuations driven by the airflow, so that the fluorine-containing solution can be fully contacted, so as to realize reverse cleaning action in a more efficient manner, improve the cleaning performance of the ultrafiltration machine, and affect the subsequent ultrafiltration processing performance of biomanufacturing. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a schematic structural diagram of a novel ultrafiltration machine for biomanufacturing in an embodiment of the utility model;

[0021] Figure 2 This is a system schematic diagram of a novel ultrafiltration machine for biomanufacturing in an embodiment of the utility model. DETAILED DESCRIPTION

[0022] The utility model is further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0023] Reference Figure 1-2 As shown, the utility model proposes a novel ultrafiltration machine for biomanufacturing, which includes a cavity 11, an air inlet pipe 21, a fan 22, a first gate valve 23, an ultrafiltration module 12, a liquid outlet pipe 31, a first pump body 32, a second gate valve 33, a reverse cleaning pipe 41, a second pump body 42, a third gate valve 43, a purification tank 13, a chlorination pump body 14 and a controller 15.

[0024] Multiple ultrafiltration modules 12 are arranged inside the cavity 11, and the cavity 11 is used to accommodate the solution that needs to be purified and filtered. The multiple ultrafiltration modules 12 realize the purification and filtration of the solution in the cavity 11. A drain pipe 16 is set at the bottom of the cavity 11 and an overflow pipe 17 is set at the top of the cavity 11.

[0025] An air inlet pipe 21 is arranged at the bottom of the cavity 11, and the air inlet pipe 21 is arranged along the width direction of the cavity 11. A plurality of air vents 211 are arranged on the air inlet pipe 21, and the plurality of air vents 211 are arranged at intervals along the length direction of the air inlet pipe 21. A fan 22 and a first gate valve 23 are respectively connected to the pipeline of the air inlet pipe 21. The fan 22 is connected to the controller 15. The airflow provided by the operation of the fan 22 enters into the interior of the cavity 11 through the air inlet pipe 21. The operating power of the fan 22 is driven by the controller 15. The air supply volume can be adjusted by adjusting the operating power of the fan 22. Specifically, the greater the operating power of the fan 22, the greater the air volume provided by the fan 22.

[0026] A liquid outlet pipe 31 is provided at the top of the ultrafiltration module 12 . The first pump body 32 and the second gate valve 33 are connected to the pipeline of the liquid outlet pipe 31 . The end of the liquid outlet pipe 31 is connected to the purification tank 13 . The first pump body 32 is connected to the controller 15 .

[0027] The reverse cleaning pipe 41 is connected to the bottom of the purification tank 13 . The pipeline of the reverse cleaning pipe 41 is connected to the second pump body 42 , the third gate valve 43 and the chlorination pump body 14 . The chlorination pump body 14 and the second pump body 42 are connected to the controller 15 .

[0028] The controller 15 is configured to drive the second pump body 42 and the chlorination pump body 14 to start working when the first pump body 32 stops working, and the solution contained in the purification tank 13 is transported through the reverse cleaning pipe 41 by the second pump body 42 and fluorine is added through the chlorination pump body 14, and the fan 22 is controlled to alternately operate at the maximum power of the fan 22 and the minimum power of the fan 22 according to a preset time period.

[0029] The preset time period is the length of time during which the fan 22 operates alternately at the maximum power of the fan 22 or the minimum power of the fan 22, wherein the operating time of the maximum power of the fan 22 is the same as the operating time of the minimum power of the fan 22. For example, the fan 22 operates at the maximum power of the fan 22 for 30 seconds, and then alternately operates at the minimum power of the fan 22 for 30 seconds, thereby controlling the fan 22 to operate alternately at the maximum power of the fan 22 and the minimum power of the fan 22 through the controller 15.

[0030] By alternately operating the fan 22 at different powers, a dynamic airflow is delivered to the interior of the cavity 11 during the backwash overshoot, so that the liquid flow inside the cavity 11 forms a dynamic fluctuation, so that the fluorine-containing solution can be fully cleaned and sterilized in the cavity 11 and the ultrafiltration module 12 in a dynamic manner. The liquid flow realizes dynamic fluctuations driven by the airflow, so that the fluorine-containing solution can be fully contacted, so as to realize the reverse cleaning action in a more efficient manner, improve the cleaning performance of the ultrafiltration machine, and affect the subsequent ultrafiltration processing performance of biomanufacturing.

[0031] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the utility model, rather than to limit it. Although the utility model has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the utility model.

Claims

1. A novel ultrafiltration machine for biomanufacturing, characterized in that: It includes a cavity, an air inlet pipe, a fan, a first gate valve, an ultrafiltration module, a liquid outlet pipe, a first pump body, a second gate valve, a reverse cleaning pipe, a second pump body, a third gate valve, a purification tank, a chlorination pump body and a controller; A plurality of the ultrafiltration modules are arranged inside the cavity, and the cavity is used to contain a solution that needs to be purified and filtered; The air inlet pipe is arranged at the bottom of the cavity, the air inlet pipe is arranged along the width direction of the cavity, a plurality of air vents are arranged on the air inlet pipe, the fan and the first gate valve are respectively connected to the pipeline of the air inlet pipe, the fan is connected to the controller, and the airflow provided by the operation of the fan enters the interior of the cavity through the air inlet pipe; The liquid outlet pipe is arranged on the top of the ultrafiltration module, the first pump body and the second gate valve are connected to the pipeline of the liquid outlet pipe, the end of the liquid outlet pipe is connected to the purification tank, and the first pump body is connected to the controller; The reverse cleaning pipe is connected to the bottom of the purification tank, the pipeline of the reverse cleaning pipe is connected to the second pump body, the third gate valve and the chlorination pump body, and the chlorination pump body and the second pump body are connected to the controller; The controller is configured to drive the second pump body and the chlorination pump body to start working when the first pump body stops working, and control the fan to alternately operate at the maximum power of the fan and the minimum power of the fan according to a preset time period.

2. The novel ultrafiltration machine for biomanufacturing as claimed in claim 1, characterized in that: The preset time period is the duration during which the fan operates alternately at the maximum power of the fan or the minimum power of the fan.

3. The novel ultrafiltration machine for biomanufacturing as claimed in claim 1, characterized in that: A drain pipe is arranged at the bottom of the cavity, and an overflow pipe is arranged at the top of the cavity.

4. The novel ultrafiltration machine for biomanufacturing as claimed in claim 1, characterized in that: The plurality of vent holes are arranged at intervals along the length direction of the air inlet pipe.

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