Rotary evaporation device for preparing sitagliptin intermediate

Abstract

The utility model belongs to the technical field of chemical synthesis of medicines, and particularly relates to a rotary evaporation device for sitagliptin intermediate action, aiming at the efficiency problem, the utility model provides the following scheme: the rotary evaporation device comprises a base; a water bath kettle is arranged on one side of the upper surface of the base; the other side of the upper surface of the machine base is fixedly connected with a rotary evaporation main machine. The outer surface of one side of the rotary evaporation main machine is fixedly connected with a connecting pipe; one side of the connecting pipe is fixedly connected with a condenser; the lower surface of the condenser is fixedly connected with a collecting bottle; and the other side of the connecting pipe is connected with a fixing mechanism in a sleeving manner. And through the arrangement of the fixing mechanism, rapid fixing of the rotary bottle is achieved, and efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of drug chemical synthesis, in particular to a sitagliptin intermediate system-assisted rotary evaporation device. Background Art

[0002] Sitagliptin has the following structural formula. It is a dipeptidyl peptidase-IV (DPP-IV) inhibitor developed by Merck in the United States. Its phosphate was approved by the US FDA in 2006 as the first DPP-IV inhibitor for clinical use in the treatment of type II diabetes. The drug has the advantages of good safety, low incidence of adverse reactions such as hypoglycemia and weight gain, etc. Sitagliptin intermediates are generally prepared by rotary evaporator.

[0003] However, the prior art still has some shortcomings. When a rotary evaporator is used in the prior art, the rotary bottle is fixed and installed by a clip. However, in some cases, the clip is easily lost, thereby reducing the working efficiency.

[0004] Therefore, we proposed a sitagliptin intermediate preparation rotary evaporation device to solve this problem. Summary of the invention

[0005] The purpose of the utility model is to solve the problems raised in the above background technology, and to propose a sitagliptin intermediate system as a rotary evaporator.

[0006] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0007] A sitagliptin intermediate-forming rotary evaporation device comprises a machine base; a water bath pot on one side of the upper surface of the machine base; a rotary evaporation main unit fixedly connected to the other side of the upper surface of the machine base; a connecting pipe fixedly connected to the outer surface of one side of the rotary evaporation main unit; a condenser fixedly connected to one side of the connecting pipe; a collecting bottle fixedly connected to the lower surface of the condenser; and a fixing mechanism sleeved on the other side of the connecting pipe.

[0008] Preferably, heat insulation plates are fixedly connected to both sides of the upper surface of the water bath; and a groove is provided on the outer surface of one side of the heat insulation plate.

[0009] Preferably, the fixing mechanism includes a first shell body sleeved on the outer circular surface of the connecting pipe; a connecting shell is rotatably mounted on the outer surface of the first shell body; a spring is fixedly connected to one end of the connecting shell; a mounting plate is fixedly connected to the outer surface of the connecting shell; a fixing block is fixedly connected to one side of the lower surface of the mounting plate; a rubber block is fixedly connected to the outer surface of one side of the fixing block; and an adjustment mechanism is fixedly connected to the inner surface of the first shell body.

[0010] Preferably, one end of the spring is fixedly connected to the inner surface of the first shell; and the fixing block is an arc-shaped block.

[0011] Preferably, the adjustment mechanism includes a threaded groove arranged on the outer surfaces of both sides of the first shell; a sliding groove is provided on the outer surface of one side of the threaded groove; a threaded rod is rotatably installed on the inner surface of the threaded groove; a rotating block is fixedly connected to one end of the threaded rod; a fixed plate is rotatably installed on the other end of the threaded rod; and a rubber pad is fixedly connected to the outer surface of one side of the fixed plate.

[0012] Preferably, the fixing plate is an arc-shaped plate; the fixing plate is slidably mounted on the inner surface of the slide groove.

[0013] In the utility model, the sitagliptin intermediate system is used as a rotary evaporator. Through the arrangement of a connecting tube, a connecting shell, a spring, a mounting plate, a fixing block, and a rubber block, when the rotating bottle is installed, the bottle mouth of the rotating bottle is pushed into one end of the connecting tube. When the rotating bottle moves, the bottle mouth of the rotating bottle will push the fixing block to move, and the movement of the fixing block will cause the spring to rotate. When the bottle mouth moves to between the fixing block and the first shell, the fixing block will fix the bottle mouth under the action of the spring rotation, thereby realizing the rapid fixation of the rotating bottle and improving the efficiency.

[0014] In the utility model, the described sitagliptin intermediate system function rotary evaporation device, through the arrangement of the first shell, the threaded groove, the slide groove, the threaded rod, the rotating block, the fixed plate, and the rubber pad, when adjusting the position of the first shell, the rotating block is rotated, the rotation of the rotating block drives the threaded rod to rotate, the rotation of the threaded rod drives the fixed plate to move, so that the fixed plate drives the rubber pad to leave the connecting pipe, and after moving to the predetermined position, the rotating block is rotated in the opposite direction, so that the fixed plate drives the rubber pad to clamp and fix the connecting pipe, thereby realizing the rapid adjustment of the position of the first shell and improving the scope of application;

[0015] The utility model has reasonable structural design, simple operation and high reliability. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 A schematic diagram of the three-dimensional structure of a rotary evaporation device for the intermediate system of sitagliptin proposed in the utility model;

[0017] Figure 2 It is a cross-sectional structural schematic diagram of the fixing mechanism in the utility model;

[0018] Figure 3 It is a cross-sectional structural schematic diagram of the adjustment mechanism in the utility model;

[0019] Figure 4 for Figure 1 A partial enlarged view of part A.

[0020] In the figure: 1, machine base; 2, water bath; 21, insulation board; 22, groove; 3, rotary evaporator; 4, connecting pipe; 5, condenser; 6, collecting bottle; 7, fixing mechanism; 71, first shell; 711, threaded groove; 712, slide groove; 713, threaded rod; 714, rotating block; 715, fixing plate; 716, rubber pad; 72, connecting shell; 73, spring; 74, mounting plate; 75, fixing block; 76, rubber block. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments.

[0022] Reference Figure 1-4 A sitagliptin intermediate system-based rotary evaporation device comprises a base 1; a water bath 2 is provided on one side of the upper surface of the base 1; a rotary evaporation main unit 3 is fixedly connected to the other side of the upper surface of the base 1; a connecting pipe 4 is fixedly connected to the outer surface of one side of the rotary evaporation main unit 3; a condenser 5 is fixedly connected to one side of the connecting pipe 4; a collecting bottle 6 is fixedly connected to the lower surface of the condenser 5; a fixing mechanism 7 is sleeved on the other side of the connecting pipe 4.

[0023] Furthermore, heat insulation plates 21 are fixedly connected to both sides of the upper surface of the water bath 2 ; a groove 22 is provided on the outer surface of one side of the heat insulation plate 21 .

[0024] Furthermore, the fixing mechanism 7 includes a first shell 71 which is sleeved on the outer circumferential surface of the connecting pipe 4; a connecting shell 72 is rotatably mounted on the outer surface of the first shell 71; a spring 73 is fixedly connected to one end of the connecting shell 72; a mounting plate 74 is fixedly connected to the outer surface of the connecting shell 72; a fixing block 75 is fixedly connected to one side of the lower surface of the mounting plate 74; a rubber block 76 is fixedly connected to the outer surface of one side of the fixing block 75; and an adjusting mechanism is fixedly connected to the inner surface of the first shell 71.

[0025] Furthermore, one end of the spring 73 is fixedly connected to the inner surface of the first housing 71; the fixing block 75 is an arc-shaped block.

[0026] Furthermore, the adjustment mechanism includes a threaded groove 711 arranged on the outer surfaces of both sides of the first shell 71; a sliding groove 712 is provided on the outer surface of one side of the threaded groove 711; a threaded rod 713 is rotatably installed on the inner surface of the threaded groove 711; a rotating block 714 is fixedly connected to one end of the threaded rod 713; a fixing plate 715 is rotatably installed on the other end of the threaded rod 713; and a rubber pad 716 is fixedly connected to the outer surface of one side of the fixing plate 715.

[0027] Furthermore, the fixing plate 715 is an arc-shaped plate; the fixing plate 715 is slidably mounted on the inner surface of the slide groove 712 .

[0028] When the rotating bottle is in use, the bottle mouth of the rotating bottle is pushed into one end of the connecting pipe 4. When the rotating bottle moves, the bottle mouth of the rotating bottle will push the fixing block 75 to move, and the movement of the fixing block 75 will cause the spring 73 to rotate. When the bottle mouth moves to between the fixing block 75 and the first shell 71, the fixing block 75 will fix the bottle mouth under the action of the rotation of the spring 73, thereby realizing the rapid fixation of the rotating bottle and improving the efficiency. When the position of the first shell 71 is adjusted, the rotating block is rotated. 714, the rotation of the rotating block 714 drives the threaded rod 713 to rotate, and the rotation of the threaded rod 713 drives the fixing plate 715 to move, so that the fixing plate 715 drives the rubber pad 716 to leave the connecting pipe 4, and after moving to the predetermined position, the rotating block 714 is rotated in the reverse direction, so that the fixing plate 715 drives the rubber pad 716 to clamp and fix the connecting pipe 4, thereby realizing the rapid adjustment of the position of the first shell 71 and improving the scope of application; the setting of the heat insulation plate 21 and the groove 22 can facilitate the removal of the water bath pot 2.

[0029] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0030] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present utility model, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0031] The preferred embodiments of the utility model disclosed above are only used to help explain the utility model. The preferred embodiments do not describe all the details in detail, nor do they limit the utility model to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the utility model, so that technicians in the relevant technical field can well understand and use the utility model. The utility model is limited only by the claims and their full scope and equivalents.

Claims

1. A sitagliptin intermediate system using a rotary evaporator, characterized in that: The invention comprises a machine base (1); a water bath (2) on one side of the upper surface of the machine base (1); a rotary evaporator (3) fixedly connected to the other side of the upper surface of the machine base (1); a connecting pipe (4) fixedly connected to the outer surface of one side of the rotary evaporator (3); a condenser (5) fixedly connected to one side of the connecting pipe (4); a collecting bottle (6) fixedly connected to the lower surface of the condenser (5); and a fixing mechanism (7) sleeved on the other side of the connecting pipe (4).

2. A sitagliptin intermediate system according to claim 1, characterized in that: Heat insulation boards (21) are fixedly connected to both sides of the upper surface of the water bath (2); a groove (22) is provided on the outer surface of one side of the heat insulation board (21).

3. A sitagliptin intermediate system according to claim 1, characterized in that: The fixing mechanism (7) comprises a first shell (71) sleeved on the outer circumferential surface of the connecting pipe (4); a connecting shell (72) is rotatably mounted on the outer surface of the first shell (71); a spring (73) is fixedly connected to one end of the connecting shell (72); a mounting plate (74) is fixedly connected to the outer surface of the connecting shell (72); a fixing block (75) is fixedly connected to one side of the lower surface of the mounting plate (74); a rubber block (76) is fixedly connected to the outer surface of one side of the fixing block (75); and an adjusting mechanism is fixedly connected to the inner surface of the first shell (71).

4. A sitagliptin intermediate system according to claim 3 using a rotary evaporator, characterized in that: One end of the spring (73) is fixedly connected to the inner surface of the first shell (71); and the fixing block (75) is an arc-shaped block.

5. A sitagliptin intermediate system according to claim 3 using a rotary evaporator, characterized in that: The adjustment mechanism comprises a threaded groove (711) arranged on the outer surfaces of both sides of the first shell (71); a sliding groove (712) is provided on the outer surface of one side of the threaded groove (711); a threaded rod (713) is rotatably mounted on the inner surface of the threaded groove (711); a rotating block (714) is fixedly connected to one end of the threaded rod (713); a fixing plate (715) is rotatably mounted on the other end of the threaded rod (713); and a rubber pad (716) is fixedly connected to the outer surface of one side of the fixing plate (715).

6. A sitagliptin intermediate system according to claim 5, characterized in that: The fixing plate (715) is an arc-shaped plate; the fixing plate (715) is slidably mounted on the inner surface of the sliding groove (712).

Images