Needle head cleaning device of spotting instrument

Abstract

The utility model discloses a needle head cleaning device of a sample application instrument. The needle head cleaning device structurally comprises a needle head inner wall cleaning chamber, a flow guide chamber and a pump machine, the needle head inner wall cleaning chamber is arranged on one side of the ultrasonic cleaning chamber, and the needle head inner wall cleaning chamber communicates with the ultrasonic cleaning chamber through the flow guide chamber; the pump machine supplies water to the needle head inner wall cleaning chamber; the ultrasonic cleaning chamber and the needle inner wall cleaning chamber are combined for use, so that the outer wall and the inner wall of the sample application needle can be thoroughly cleaned, and cross contamination of samples is effectively avoided; due to the design of the flow guide chamber, cleaning liquid can smoothly flow to the ultrasonic cleaning chamber from the needle head inner wall cleaning chamber, and therefore water in the ultrasonic cleaning chamber can be accumulated.

Description

Technical Field

[0001] The utility model relates to a needle cleaning device for a spotting instrument, belonging to the field of spotting needle cleaning. Background Art

[0002] Nucleic acid mass spectrometry refers to the process of analyzing nucleic acids (DNA or RNA) using mass spectrometry technology. In nucleic acid mass spectrometry, the nucleic acid sample is first ionized by a mass spectrometer, and then the mass-to-charge ratio of the ions is measured by the mass spectrometer to obtain the mass spectrum of the nucleic acid. By analyzing the mass spectrum, nucleic acid sequence information, modification information, structural information, etc. can be obtained, thereby helping researchers conduct in-depth research on nucleic acids.

[0003] Nucleic acid mass spectrometry technology has a wide range of applications in biomedical research, genetics research, drug development and other fields. Including nucleic acid sequencing, DNA modification analysis, protein-nucleic acid interaction research, drug screening and drug development. Through nucleic acid mass spectrometry technology, rapid, sensitive and efficient analysis of nucleic acid samples can be achieved, providing powerful tools and means for scientific researchers. As a pre-treatment device for nucleic acid mass spectrometry, the fully automatic spotter has the characteristics of high throughput, good stability, and efficient automation. In the process of spotting, cross-contamination of samples is involved, so most spotters on the market are equipped with cleaning tanks, such as CN116351795A and CN213856042U, which describe and study the cleaning tank.

[0004] Both of these invented cleaning tanks use ultrasonic cleaning, which to a certain extent takes the cleaning process into more comprehensive considerations. However, it is difficult to clean spotting needles of different specifications, so impurities may still exist on the inner wall of the spotting needle. Utility Model Content

[0005] In view of the deficiencies in the prior art, the utility model aims to provide a needle cleaning device for a spotting instrument to solve the problem.

[0006] In order to achieve the above-mentioned purpose, the utility model is realized by the following technical scheme: a needle cleaning device of a spotting instrument, whose structure includes an ultrasonic cleaning chamber; the spotting needle is inserted into the ultrasonic cleaning chamber for cleaning, characterized in that: its structure also includes a needle inner wall cleaning chamber, a diversion chamber, and a pump; the needle inner wall cleaning chamber is arranged on one side of the ultrasonic cleaning chamber, and the needle inner wall cleaning chamber is connected with the ultrasonic cleaning chamber through the diversion chamber; the pump supplies water to the needle inner wall cleaning chamber;

[0007] The needle inner wall cleaning chamber includes a plurality of open cleaning chambers, a nozzle arranged at the bottom of the cleaning chamber, a water inlet channel for connecting the pump and the nozzle, and a drainage channel for discharging the liquid in the cleaning chamber; the water inlet end of the drainage channel is lower than the water outlet height of the nozzle.

[0008] Preferably, one side of the ultrasonic cleaning chamber is provided with a bottom liquid outlet arranged at the bottom of the ultrasonic cleaning chamber and a top liquid outlet arranged near the top of the ultrasonic cleaning chamber; a valve is installed on the bottom liquid outlet.

[0009] Preferably, the guide chamber includes a flow groove surrounding the outer edge of the cleaning chamber on the inner wall of the needle, and a slope corresponding to the ultrasonic cleaning chamber; the water outlet end of the drainage channel corresponds to the slope.

[0010] Preferably, the nozzle is designed to be conical, and the water outlet diameters of the nozzles in the plurality of cleaning chambers are all different.

[0011] Preferably, the water inlet channel includes a water supply channel for connecting to a pump, a flow channel for diversion, and a branch channel connecting various nozzles; water flows from the water supply channel to the flow channel and then to the branch channel in sequence.

[0012] Preferably, the drainage channel includes a drainage hole connected to the cleaning chamber and a water outlet for connecting the drainage holes; the water outlet is arranged at a height higher than the diversion chamber.

[0013] Beneficial Effects

[0014] The utility model can thoroughly clean the outer wall and inner wall of the spotting needle through the combined use of the ultrasonic cleaning chamber and the needle inner wall cleaning chamber, effectively avoiding sample cross contamination; the design of the diversion chamber allows the cleaning liquid to flow smoothly from the needle inner wall cleaning chamber to the ultrasonic cleaning chamber, so that the water in the ultrasonic cleaning chamber can be accumulated. Multiple nozzles of different calibers are designed, so that spotting needles of various models and specifications can be cleaned. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Other features, objects and advantages of the present invention will become more apparent by reading the detailed description of non-limiting embodiments with reference to the following drawings:

[0016] Figure 1 It is a structural schematic diagram of a needle cleaning device of a spotting instrument of the utility model;

[0017] Figure 2 It is a schematic diagram of the structure of the utility model from a top view;

[0018] Figure 3 It is a schematic structural diagram of the utility model from the side. DETAILED DESCRIPTION

[0019] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further described below in conjunction with specific implementation methods.

[0020] See also Figure 1-Figure 3The utility model provides a technical solution for a needle cleaning device of a spotting instrument: its structure includes an ultrasonic cleaning chamber 1, a needle inner wall cleaning chamber 2, a diversion chamber 3, and a pump 5; the spotting needle is inserted into the ultrasonic cleaning chamber 1 for cleaning; the needle inner wall cleaning chamber 2 is arranged on one side of the ultrasonic cleaning chamber 1, and the needle inner wall cleaning chamber 2 is connected with the ultrasonic cleaning chamber 1 through the diversion chamber 3; the pump 5 supplies water to the needle inner wall cleaning chamber 2. In this way, the water in the needle inner wall cleaning chamber 2 can flow from the diversion chamber 3 to the ultrasonic cleaning chamber 1 after overflowing, so as to store water in the ultrasonic cleaning chamber 1. The user can perform preliminary cleaning in the ultrasonic cleaning chamber 1, which mainly cleans the outer wall of the spotting needle (not shown in the figure), and then insert the spotting needle into the needle inner wall cleaning chamber 2 for secondary cleaning, which mainly cleans the inner wall of the spotting needle.

[0021] The needle inner wall cleaning chamber 2 includes several open cleaning chambers 21, nozzles 22 arranged at the bottom of the cleaning chamber 21, a water inlet channel 23 for connecting the pump 5 with the nozzles 22, and a drainage channel 24 for discharging the liquid in the cleaning chamber 21; the water inlet end of the drainage channel 24 is lower than the water outlet height of the nozzles 22. In one embodiment, the cleaning chamber 21 is provided with 6 circular grooves, which are distributed in 2 rows on one side of the ultrasonic cleaning chamber 1; the nozzles 22 are preferably conical in design, and the water outlet diameters of the nozzles 22 in several cleaning chambers 21 are different, so that different specifications of spotting needles can be cleaned, and further, a label can be made on one side of the cleaning chamber 21 to distinguish the corresponding nozzle 22 diameter, so that users can quickly find the cleaning chamber 21 of the appropriate specifications.

[0022] In order to solve the problem of the pump 5 supplying water to several nozzles 22 at the same time, a water inlet channel 23 is designed inside the needle inner wall cleaning chamber 2; the water inlet channel 23 includes a water supply channel 231 for connecting to the pump 5, a flow channel 232 for diversion, and a branch channel 233 connecting each nozzle 22; in this way, water flows from the water supply channel 231 to the flow channel 232 and then to the branch channel 233 in sequence, and is thus delivered to each nozzle 22.

[0023] In order to prevent the nozzle 22 from spraying water due to excessive water in the cleaning chamber 21 and to facilitate the water in the cleaning chamber 21 to flow into the diversion chamber 3, a drainage channel 24 is set up, and the drainage channel 24 includes a drainage hole 242 connected to the cleaning chamber 21 and a water outlet 241 for connecting each drainage hole 242; wherein the drainage hole 242 will serve as the water inlet end of the drainage channel 24, and the drainage hole 242 is lower than the water outlet height of the nozzle 22, so that the accumulation of water will not affect the water spraying of the nozzle 22. Further, the height of the setting of the water outlet 241 is higher than the diversion chamber 3, so that the water flowing out of the water outlet 241 will not be affected by the water in the diversion chamber 3, thereby avoiding the backflow of water.

[0024] In order to further solve the problem of drainage of the ultrasonic cleaning chamber 1 and excessive water overflowing from the ultrasonic cleaning chamber 1, a bottom liquid outlet 51 arranged at the bottom of the ultrasonic cleaning chamber 1 and a top liquid outlet 52 arranged near the top of the ultrasonic cleaning chamber 1 are provided on one side of the ultrasonic cleaning chamber 1; a valve is installed on the bottom liquid outlet 51. In this way, when it is necessary to drain the ultrasonic cleaning chamber 1, after turning off the pump 5, the bottom liquid outlet 51 is opened, because the water in the ultrasonic cleaning chamber 1 can be completely discharged from the bottom liquid outlet 51. Furthermore, a drainage groove 511 is provided on the front side of the bottom liquid outlet 51, and the drainage groove 511 is recessed at the bottom of the ultrasonic cleaning chamber 1, so that it is more convenient for the water in the ultrasonic cleaning chamber 1 to be discharged from the bottom liquid outlet 51.

[0025] To facilitate the water in the needle inner wall cleaning chamber 2 to flow to the ultrasonic cleaning chamber 1, the diversion chamber 3 is provided, including a flow groove 32 surrounding the outer edge of the needle inner wall cleaning chamber 2 and a slope 31 corresponding to the ultrasonic cleaning chamber 1; the water outlet 241 corresponds to the slope 31; the design of the slope 31 allows the water from the water outlet 241 to flow naturally to the ultrasonic cleaning chamber 1, thereby avoiding excessive accumulation of water in the diversion chamber 3. The reason why the flow groove 32 is designed on the outer edge of the needle inner wall cleaning chamber 2 is that some nozzles 22 with small diameters may spray water out of the cleaning chamber 21 due to water pressure, and the flow groove 32 can guide this part of the water to the slope 31.

[0026] Preferably, the shells of the needle inner wall cleaning chamber 2 and the ultrasonic cleaning chamber 1 are both made of Teflon material. In terms of performance, the Teflon material is non-sticky: it makes it easier for the residual waste liquid left after cleaning to be discharged with the flow of water, keeping the cleaning tank clean, and because of the excellent non-stick effect, only ultrapure water is needed for daily maintenance and cleaning. If you encounter stubborn stains, you can use 75% alcohol for auxiliary cleaning, which is simple and convenient. Chemical resistance: It has good stability to a variety of chemical substances such as acids, alkalis, and organic solvents, is not easily corroded, and is suitable for a variety of biological agents. Stability: It is not easily aged by factors such as light, heat, and oxidation, and has a long service life.

[0027] The water mentioned above in this patent will be ultrapure water in one of the embodiments.

[0028] Working principle: turn on the pump 5 to introduce ultrapure water as the washing liquid, the washing liquid will flow from the water supply channel 231 to the flow channel 232 and then to the branch channel 233, and be sprayed out from the nozzle 22, and the sprayed washing liquid will flow from the drainage hole 242 to the outlet channel 241, and the washing liquid will flow from the diversion chamber 3 to the ultrasonic cleaning chamber 1. After waiting for a certain period of time, as the washing liquid in the ultrasonic cleaning chamber 1 gradually accumulates, turn on the corresponding ultrasonic cleaning function (which is a function of the prior art and will not be described in detail in the specification), and then the user inserts the spotting needle into the ultrasonic cleaning chamber 1 for ultrasonic cleaning, and then inserts the spotting needle into the cleaning chamber 21, places the spotting needle in the corresponding nozzle, and the washing liquid sprayed by the nozzle will flush the inner wall of the needle of the spotting needle.

[0029] The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. It is obvious to those skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present invention is defined by the attached claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims are included in the present invention. Any figure mark in the claims should not be regarded as limiting the claims involved.

[0030] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A needle cleaning device for a spotting instrument, the structure of which includes an ultrasonic cleaning chamber; the spotting needle is inserted into the ultrasonic cleaning chamber for cleaning, characterized in that: Its structure also includes a needle inner wall cleaning chamber, a diversion chamber, and a pump; the needle inner wall cleaning chamber is arranged on one side of the ultrasonic cleaning chamber, and the needle inner wall cleaning chamber is connected with the ultrasonic cleaning chamber through the diversion chamber; the pump supplies water to the needle inner wall cleaning chamber; The needle inner wall cleaning chamber includes a plurality of open cleaning chambers, a nozzle arranged at the bottom of the cleaning chamber, a water inlet channel for connecting the pump and the nozzle, and a drainage channel for discharging the liquid in the cleaning chamber; the water inlet end of the drainage channel is lower than the water outlet height of the nozzle.

2. The needle cleaning device of the spotting instrument according to claim 1, characterized in that: One side of the ultrasonic cleaning chamber is provided with a bottom liquid outlet arranged at the bottom of the ultrasonic cleaning chamber and a top liquid outlet arranged near the top of the ultrasonic cleaning chamber; a valve is installed on the bottom liquid outlet.

3. The needle cleaning device of the spotting instrument according to claim 1, characterized in that: The flow guide chamber includes a flow groove surrounding the outer edge of the cleaning chamber on the inner wall of the needle and a slope corresponding to the ultrasonic cleaning chamber; the water outlet end of the drainage channel corresponds to the slope.

4. The needle cleaning device of a spotting instrument according to claim 1, characterized in that: The nozzle is designed to be conical, and the water outlet diameters of the nozzles in the plurality of cleaning chambers are all different.

5. The needle cleaning device of a spotting instrument according to claim 1, characterized in that: The water inlet channel comprises a water supply channel for connecting with a pump, a flow channel for diversion, and a branch channel connecting various nozzles; water flows from the water supply channel to the flow channel and then to the branch channel in sequence.

6. The needle cleaning device of a spotting instrument according to claim 1, characterized in that: The drainage channel comprises a drainage hole connected with the cleaning cavity and a water outlet channel used to connect the drainage holes; the water outlet channel is arranged at a height higher than the diversion chamber.

Images