Feeding device of magnetic bead purification instrument

Abstract

The utility model discloses a feeding device of a magnetic bead purifier, which relates to the technical field of experimental instruments, the magnetic bead purifier comprises a sample bin and a tray, the top of the tray is provided with a kit notch, the feeding device is arranged at the top of a platform, the feeding device comprises a limiting mechanism and a first clamping mechanism, the top of the limiting box is provided with a limiting groove used for placing a kit, and the first clamping mechanism is arranged at the top of the limiting box; windows are formed in two opposite side walls of the limiting box, two square clamping plates of the first clamping mechanism are respectively arranged at the windows and are used for clamping a kit, and sealing paper is arranged at the top of the kit; the paper tearing mechanism comprises a linear stroke assembly, two clamping strips and a clamping strip control box, the clamping strip control box is used for controlling the vertical distance between the two clamping strips, the clamping strips are used for clamping one end of the sealing paper, and the linear stroke assembly is used for moving the clamping strip control box; and the transfer mechanism is used for moving the kit in the limiting groove into the kit notch. According to the scheme, the sealing paper at the top of the kit can be automatically torn, and the kit can be automatically placed in the magnetic bead purification instrument.

Description

Technical Field

[0001] The utility model relates to the technical field of experimental instruments, in particular to a feeding device for a magnetic bead purification instrument. Background Art

[0002] Magnetic bead purification instrument is a kind of equipment used in biological laboratories, usually used to separate and purify specific target molecules or cells from a mixture. This equipment uses the specific binding between magnetic beads and target molecules or cells to achieve the separation and purification process through magnetic field control. It is widely used in the fields of molecular biology, immunology and cell biology, and can process and separate samples efficiently and quickly.

[0003] The use process of the magnetic bead purifier is as follows: the staff takes out multiple test kits from the packaging box and places them on the laboratory bench; tears off the sealing paper on the top of the test kit and uses a pipette to add the sample to the corresponding solution of the test kit; the sample compartment of the magnetic bead purifier is opened, and the tray extends from the inside. The staff places multiple test kits with samples added into the slot on the top of the tray; finally, the tray slowly enters the instrument and the sample compartment is closed. The above use process has the following problems: manually tearing off the sealing paper on the top of the test kit and manually placing the test kit with samples added into the tray. These two steps are not only inefficient, but also have the risk of knocking over the test kit. Utility Model Content

[0004] In order to solve the deficiencies of the prior art, the utility model provides a feeding device for a magnetic bead purifier, which can automatically tear off the sealing paper and automatically place the reagent kit in the magnetic bead purifier.

[0005] In order to achieve the purpose of this utility model, the following scheme is proposed:

[0006] A feeding device for a magnetic bead purifier comprises a sample chamber and a tray arranged therein, a reagent box notch is arranged on the top of the tray, and the feeding device is arranged on the top of the platform and comprises a limiting mechanism, a paper tearing mechanism and a transfer mechanism.

[0007] The limiting mechanism includes a limiting box and a first clamping mechanism. The limiting box is provided with a limiting groove on the top for placing the reagent kit. The two opposite side walls of the limiting box are provided with windows. Two square clamping plates of the first clamping mechanism are respectively provided at the windows for clamping the reagent kit. A sealing paper is provided on the top of the reagent kit.

[0008] The paper tearing mechanism includes a linear travel component, two clamping strips and a clamping strip control box, the clamping strip control box is used to control the upper and lower spacing of the two clamping strips, the clamping strip is used to clamp one end of the sealing paper, and the linear travel component is used to move the clamping strip control box;

[0009] The transfer mechanism is used to move the reagent box in the limiting groove to the reagent box slot.

[0010] Furthermore, the first clamping mechanism includes a handwheel, a first screw rod and a guide rod. The ends of the first screw rod and the guide rod are respectively rotatably connected to the four bases on the top of the platform. The limit box is located between the first screw rod and the guide rod. The threads at both ends of the first screw rod are opposite. The handwheel is used to rotate the first screw rod. A movable plate is provided on the outside of the square clamp. One end of the movable plate is slidably engaged with the guide rod, and the other end is threadedly engaged with the first screw rod.

[0011] Furthermore, the linear travel component is located between the limit box and the tray, and includes a motor and a second screw rod. The second screw rod is rotatably arranged between the two support blocks. The motor is used to drive the second screw rod. A slider is provided at the bottom of the clamp control box. The bottom surface of the slider is close to the platform, and the slider thread is matched with the second screw rod.

[0012] Furthermore, the paper tearing mechanism also includes a gear and a rack, and both ends of the rack are connected to the corresponding support blocks through smooth rods. The gear rotation is arranged on the side of the clamp control box facing the tray, and the gear is located at the smooth rod. When the clamp clamps one end of the sealing paper, the gear is used to engage the rack.

[0013] Furthermore, the transfer mechanism includes two L-shaped splints, a control box and a slide rail. One end of the slide rail is arranged at the top of the magnetic bead purification instrument, and the other end extends to above the limit box, which is used to move the control box in a straight line. A lifting rod is provided on the top of the L-shaped splint, and the top of the lifting rod is connected to the control box. The two L-shaped splints are used to clamp the two ends of the test kit.

[0014] The beneficial effect of the utility model is that the sealing paper on the top of the test kit can be automatically torn off, and the test kit can be automatically placed in the tray of the magnetic bead purification instrument, thereby improving the experimental efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 The structure diagram of the feeding device of the magnetic bead purification instrument is shown;

[0016] Figure 2 A diagram of the limit box structure is shown;

[0017] Figure 3 A top view of the limiting mechanism and the paper tearing mechanism is shown. DETAILED DESCRIPTION

[0018] like Figure 1 , Figure 2 As shown, this embodiment provides a loading device for a magnetic bead purifier. The magnetic bead purifier 1 includes a sample chamber 11 and a tray 12 arranged in the sample chamber 11. A reagent reagent slot 121 is provided on the top of the tray 12. The magnetic bead purifier 1 is a conventional instrument, and its structure and principle are not elaborated in detail here. The loading device is used to automatically tear off the sealing paper 61 on the top of the reagent reagent 6 and automatically place the reagent reagent 6 in the reagent reagent slot 121.

[0019] The specific implementation method is as follows: the feeding device is arranged on the top of the platform 5, including a limiting mechanism 2, a paper tearing mechanism 3 and a transfer mechanism 4.

[0020] like Figure 1 , Figure 2 As shown, the limiting mechanism 2 includes a limiting box 21 and a first clamping mechanism. A limiting groove is provided on the top of the limiting box 21, and the limiting groove is used to place the reagent box 6. Windows 212 are provided on the opposite side walls of the limiting box 21. Two square clamping plates 22 of the first clamping mechanism are respectively provided at the windows 212. The two square clamping plates 22 are used to clamp the reagent box 6 so that the sealing paper 61 on the top of the reagent box 6 can be torn off by using the paper tearing mechanism 3.

[0021] The first clamping mechanism is specifically implemented as follows: Figure 1 , Figure 3 As shown, the first clamping mechanism includes a handwheel 24, a first screw rod 25 and a guide rod 23. The first screw rod 25 and the guide rod 23 are parallel to each other, and the ends of the two are rotatably connected to the four bases on the top of the platform 5. The limit box 21 is located between the first screw rod 25 and the guide rod 23. The threads at both ends of the first screw rod 25 are opposite. One end of the first screw rod 25 passes through the corresponding base and is connected to the handwheel 24. The handwheel 24 is used to rotate the first screw rod 25. A movable plate 26 is provided on the outer side of each square clamp plate 22. One end of the movable plate 26 is slidably matched with the guide rod 23, and the other end of the movable plate 26 is threadedly matched with the first screw rod 25.

[0022] The method for fixing the reagent kit 6 is as follows: the staff takes out a reagent kit 6 from the packaging box and puts it into the limiting groove; the hand wheel 24 is turned to make the two square clamping plates 22 gather together, so as to fix the reagent kit 6.

[0023] like Figure 1 , Figure 2 As shown, the paper tearing mechanism 3 includes a linear travel component, two clamping strips 32 and a clamping strip control box 33. The clamping strip control box 33 is used to control the upper and lower spacing between the two clamping strips 32. The clamping strip 32 is used to clamp one end of the sealing paper 61. The linear travel component is used to move the clamping strip control box 33. There are many ways to implement the linear travel component, such as Figure 3 As shown, in this embodiment, the linear travel component is located between the limit box 21 and the tray 12, and includes a motor 312 and a second screw rod 311. The second screw rod 311 is rotatably arranged between the two support blocks. One end of the second screw rod 311 passes through the support block and is connected to the output shaft of the motor 312. The motor 312 is used to drive the second screw rod 311. A slider is provided at the bottom of the clamp control box 33. The bottom surface of the slider is close to the platform 5, and the slider thread is matched with the second screw rod 311.

[0024] In this embodiment, the length of the sealing paper 61 is greater than the length of the reagent box 6, and both ends of the sealing paper 61 extend beyond the reagent box 6 by about 1 cm to 3 cm. Figure 3 From the perspective, the motor 312 drives the second screw rod 311 to move the slider, the clamp control box 33 and the two clamps 32 thereon to the left end of the sealing paper 61, and the left end of the sealing paper 61 is located between the two clamps 32; the clamp control box 33 is used to reduce the distance between the two clamps 32 until the clamp 32 clamps the left end of the sealing paper 61, and at this time the bottom surface of the lower clamp 32 is higher than the top surface of the reagent box 6; the motor 312 continues to drive the second screw rod 311 to move the slider, the clamp control box 33 and the two clamps 32 thereon to the right, and the sealing paper 61 is gradually torn open during the movement of the clamp 32 to the right.

[0025] This embodiment also provides another paper tearing method, which is as follows: Figure 1 , Figure 3 As shown, the paper tearing mechanism 3 also includes a gear 34 and a rack 35. Both ends of the rack 35 are connected to the corresponding support blocks through smooth rods 351. The gear 34 is rotatably arranged on the side of the clamp control box 33 facing the tray 12. When not in use, the gear 34 is located at the smooth rod 351.

[0026] Another way to tear paper is as follows: Figure 3 From the perspective, the motor 312 drives the second screw rod 311 to move the slider, the clamp control box 33 and the two clamps 32 thereon to the left end of the sealing paper 61, and the left end of the sealing paper 61 is located between the two clamps 32; the clamp control box 33 is used to reduce the distance between the two clamps 32 until the clamp 32 clamps the left end of the sealing paper 61, and the bottom surface of the lower clamp 32 is higher than the top surface of the reagent box 6; the motor 312 continues to drive the second screw rod 311 to move the slider, the clamp control box 33 and the two clamps 32 thereon to the right. During this process, the gear 34 begins to mesh with the rack 35, causing the gear 34 to rotate, thereby wrapping the sealing paper 61 around the clamp 32.

[0027] like Figure 1 As shown, the transfer mechanism 4 is used to move the reagent kit 6 in the limit groove to the reagent kit slot 121, and the specific implementation method is as follows: the transfer mechanism 4 includes two L-shaped clamps 41, a control box 42 and a slide rail 43, one end of the slide rail 43 is arranged at the top of the magnetic bead purification instrument 1, and the other end of the slide rail 43 extends to the top of the limit box 21, and the slide rail 43 is used to linearly move the control box 42, and a lifting rod 44 is provided on the top of the L-shaped clamp 41, and the top of the lifting rod 44 is connected to the control box 42. The power source of the lifting rod 44 can be driven by a cylinder, an oil cylinder or a hydraulic drive, and the control box 42 is used to adjust the distance between the two L-shaped clamps 41, and the two L-shaped clamps 41 are used to clamp the two ends of the reagent kit 6.

[0028] The method for transferring the reagent kit 6 is as follows: use the paper tearing mechanism 3 to tear off the sealing paper 61 of the reagent kit 6, and the staff uses a pipette to add the sample to the solution corresponding to the reagent kit 6; the two lifting rods 44 synchronously move the L-shaped clamp 41 downward until the cross section of the L-shaped clamp 41 is lower than the end of the reagent kit 6; use the control box 42 to reduce the distance between the two L-shaped clamps 41 until the L-shaped clamp 41 clamps the end of the reagent kit 6; the two lifting rods 44 synchronously move the L-shaped clamp 41 and the reagent kit 6 upward, and when the reagent kit 6 is completely out of the limit groove, use the slide rail 43 to move the L-shaped clamp 41 and the reagent kit 6 as a whole to the top of the tray 12, and put the reagent kit 6 into the corresponding reagent kit slot 121 under the action of the lifting rod 44.

[0029] The above embodiments are only used to illustrate the technical ideas and features of the utility model, and are not intended to be the only or limit the utility model. Those skilled in the art should understand that various changes or equivalent replacements made to the utility model without departing from the scope of the utility model are within the scope of protection of the utility model.

Claims

1. A loading device for a magnetic bead purifier, the magnetic bead purifier (1) comprising a sample chamber (11) and a tray (12) arranged therein, the top of the tray (12) being provided with a reagent box notch (121), characterized in that: The loading device is arranged on the top of the platform (5), and comprises: The limiting mechanism (2) comprises a limiting box (21) and a first clamping mechanism, wherein a limiting groove is provided on the top of the limiting box (21) for placing the reagent box (6), windows (212) are provided on two opposite side walls of the limiting box (21), two square clamping plates (22) of the first clamping mechanism are respectively provided at the windows (212) for clamping the reagent box (6), and a sealing paper (61) is provided on the top of the reagent box (6); The paper tearing mechanism (3) comprises a linear travel component, two clamping strips (32) and a clamping strip control box (33), wherein the clamping strip control box (33) is used to control the upper and lower spacing between the two clamping strips (32), the clamping strip (32) is used to clamp one end of the sealing paper (61), and the linear travel component is used to move the clamping strip control box (33); The transfer mechanism (4) is used to move the reagent box (6) in the limiting groove to the reagent box slot (121).

2. The magnetic bead purification instrument feeding device according to claim 1, characterized in that: The first clamping mechanism comprises a hand wheel (24), a first screw rod (25) and a guide rod (23), the ends of the first screw rod (25) and the guide rod (23) are rotatably connected to four bases on the top of the platform (5), the limit box (21) is located between the first screw rod (25) and the guide rod (23), the threads at both ends of the first screw rod (25) are opposite, the hand wheel (24) is used to rotate the first screw rod (25), and a movable plate (26) is provided on the outer side of the square clamp plate (22), one end of the movable plate (26) is slidably matched with the guide rod (23), and the other end is threadedly matched with the first screw rod (25).

3. The magnetic bead purification instrument feeding device according to claim 1, characterized in that: The linear travel component is located between the limit box (21) and the tray (12), and comprises a motor (312) and a second screw rod (311). The second screw rod (311) is rotatably arranged between the two support blocks, and the motor (312) is used to drive the second screw rod (311). A slider is provided at the bottom of the clamping bar control box (33), the bottom surface of the slider is closely attached to the platform (5), and the slider thread is matched with the second screw rod (311).

4. The magnetic bead purification instrument feeding device according to claim 2, characterized in that: The paper tearing mechanism (3) further comprises a gear (34) and a rack (35), the two ends of the rack (35) being connected to corresponding support blocks via smooth rods (351), the gear (34) being rotatably arranged on the side of the clamping strip control box (33) facing the tray (12), the gear (34) being located at the smooth rod (351), and when the clamping strip (32) clamps one end of the sealing paper (61), the gear (34) is used to mesh with the rack (35).

5. The magnetic bead purification instrument feeding device according to claim 1, characterized in that: The transfer mechanism (4) comprises two L-shaped clamps (41), a control box (42) and a slide rail (43). One end of the slide rail (43) is arranged on the top of the magnetic bead purification instrument (1), and the other end extends to the top of the limit box (21) for linearly moving the control box (42). A lifting rod (44) is arranged on the top of the L-shaped clamp (41), and the top of the lifting rod (44) is connected to the control box (42). The two L-shaped clamps (41) are used to clamp the two ends of the reagent kit (6).

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