Impurity removal device for heparin sodium crude product

Abstract

The utility model discloses a heparin sodium crude product impurity removal device, which belongs to the technical field of heparin sodium crude product impurity removal, and adopts the technical scheme that the heparin sodium crude product impurity removal device comprises a tank body, an impurity removal mechanism is arranged on one side of the tank body, a cleaning assembly is arranged on one side of the tank body, and a filtering assembly is arranged at the bottom of the tank body. When the device is used, the impurity removal mechanism can stir the heparin sodium mixed with a buffer solution, so that the buffer solution and the heparin sodium are uniformly mixed, impurities contained in the heparin sodium are separated, then the impurities can be fished, the impurity removal mechanism can be cleaned more conveniently when the device is used by arranging the cleaning assembly, and the cleaning efficiency is improved. By arranging the filtering assembly, heparin sodium can be filtered again during use, the impurity removal effect is improved, by arranging the moving assembly, the tank body can be conveniently moved during use, and by arranging the fixing assembly, the tank body can be fixed during use, and the tank body is prevented from moving during use.

Description

Technical Field

[0001] The utility model relates to the technical field of crude sodium heparin impurity removal, in particular to a crude sodium heparin impurity removal device. Background Art

[0002] Heparin sodium is a commonly used anticoagulant and a type of heparin drug. It is extracted from the lungs or intestinal mucosa of animals (such as pigs, cattle, chickens, etc.) and is produced through a series of chemical treatments and purification processes. Heparin sodium has an anticoagulant effect, mainly by inhibiting the activity of thrombin and blocking the formation of coagulation. It can bind to antithrombin III (AT-III) and enhance the coagulation inhibitory activity of AT-III, thereby inhibiting the activity of thrombin, activated factor Xa and coagulation factor IXa, and then inhibiting the coagulation process. Heparin sodium can separate the impurities it contains by adding the corresponding buffer.

[0003] The Chinese utility model patent currently announced as: CN218108291U discloses a crude heparin sodium impurity removal device, including a tank body, the upper end of the tank body is connected to a feed port, the interior of the tank body is connected to a stirring device, the bottom end of the tank body is connected to a tank seat, the bottom end of the tank seat is connected to a support rod, the bottom end of the support rod is connected to a roller, the upper end of the tank seat is connected to a heater, the upper end of the heater is connected to an air pipe, the interior of the tank body is connected to an annular sleeve, the bottom end of the annular sleeve is connected to a filter screen, the bottom end of the filter screen is connected to a base, the bottom end of the base is connected to a cylinder, the upper end of the cylinder is connected to a ball nut, the interior of the ball nut is connected to a lead screw, and a device that can drive the filter screen to automatically bring the filter screen out of the interior of the tank body is provided. The operator only needs to replace the filter screen outside the tank body, making the whole process easier to operate, convenient and fast. Secondly, a roller is provided to facilitate the transportation of the tank body, thereby effectively solving the problems and shortcomings of the existing device.

[0004] Although this patent has the effect of facilitating the replacement of the filter and the transportation of the tank, it is unable to fix the tank during actual use, causing the tank to move around and become unstable during operation. At the same time, the mixing and stirring effect is poor and cannot effectively remove impurities from the sodium heparin. Utility Model Content

[0005] 1. Technical problems to be solved

[0006] The utility model provides a crude sodium heparin impurity removal device, aiming to solve the problem that the existing crude sodium heparin impurity removal device cannot fix the tank body during actual use, resulting in the tank body moving around and being unstable during operation, and the mixing and stirring effect is poor and the sodium heparin cannot be well impurity removed.

[0007] 2. Technical solution

[0008] The utility model is implemented as follows: a crude heparin sodium impurity removal device comprises a tank body, a side of the tank body is provided with an impurity removal mechanism, a side of the tank body is provided with a cleaning component, a bottom of the tank body is provided with a filtering component, a bottom of the cleaning component is provided with a moving component, and one side of the moving component is provided with a fixed component;

[0009] The impurity removal mechanism includes a sealing cover, an inlet, a motor, a rotating rod, a stirring rod, a rotating ring, a salvaging net and a discharge port. The sealing cover is plugged into the top of the tank body, the inlet is arranged at the top of the sealing cover, the motor is bolted to the top of the sealing cover, the rotating rod is fixedly connected to the output end of the motor, a plurality of stirring rods are fixedly connected to one side of the rotating rod, the rotating ring is rotatably connected to one side of the stirring rod, a plurality of salvaging nets are fixedly connected to one side of the rotating ring, and the discharge port is arranged at the bottom of the tank body.

[0010] In order to facilitate the cleaning of the interior of the tank body, a crude sodium heparin impurity removal device is preferably used in the utility model. The cleaning assembly includes a fixing ring, a hydraulic rod and a support plate. The fixing ring is fixedly connected to one side of the tank body, and multiple hydraulic rods are bolted to the top of the fixing ring. Multiple support plates are fixedly connected to one side of the sealing cover and are respectively bolted to multiple hydraulic rods.

[0011] In order to achieve the effect of increasing the removal of impurities, as a preferred device for removing impurities from crude sodium heparin of the utility model, the filter assembly includes an isolation plate, a solenoid valve and a filter screen, the isolation plate is bolted to the inside of the tank body, the solenoid valve is arranged on one side of the isolation plate, and the two filter screens are bolted to the bottom of the tank body.

[0012] In order to achieve the effect of increasing the flexibility of the tank body, as a preferred crude sodium heparin impurity removal device of the utility model, the moving component includes support legs and universal wheels, a plurality of the support legs are fixedly connected to the bottom of the fixed ring, and the universal wheels are arranged at the bottom of the support legs.

[0013] In order to achieve the effect of fixing the tank body against the ground, as a preferred crude sodium heparin impurity removal device of the utility model, the fixing assembly includes an extension plate, a fixing plate, a threaded column, a slide groove and a fixing block, the extension plate is fixedly connected to one side of the supporting leg, the fixing plate is fixedly connected to one side of the supporting leg, the threaded column is rotatably connected between the extension plate and the fixing plate, the slide groove is opened on one side of the supporting leg, and the fixing block is slidably connected to the inside of the slide groove and is threadedly connected to the threaded column.

[0014] In order to achieve the effect of expanding the feeding area of ​​the feeding port and facilitating use, as a preferred device for removing impurities from crude sodium heparin of the utility model, an expansion port is provided on the top of the feeding port.

[0015] In order to achieve the effect of first filtering the sodium heparin simply, as a preferred device for removing impurities from the crude sodium heparin of the utility model, a filter bucket is provided inside the feed inlet.

[0016] In order to achieve the effect of increasing the fixing effect of the fixing block, as a preferred device for removing impurities from crude sodium heparin of the utility model, the bottom of the fixing block is fixedly connected with an anti-sliding block.

[0017] 3. Beneficial effects

[0018] Compared with the prior art, the beneficial effects of the utility model are:

[0019] The crude sodium heparin impurity removal device is provided with an impurity removal mechanism. When in use, the impurity removal mechanism can stir the sodium heparin mixed with a buffer solution, so that the buffer solution and the sodium heparin are uniformly mixed, and the impurities contained in the sodium heparin are separated, and then the impurities can be salvaged; by providing a cleaning component, the impurity removal mechanism can be more conveniently cleaned when in use; by providing a filtering component, the sodium heparin can be filtered again when in use to increase the impurity removal effect; by providing a moving component, the tank body can be conveniently moved when in use; by providing a fixing component, the tank body can be fixed when in use to prevent the tank body from moving when in use; by providing a sealing cover, a feed inlet, a motor, a rotating rod, a stirring rod, a rotating ring, a salvaging net and a feed outlet, when in use, the buffer solution and the sodium heparin are added into the tank body through the feed inlet, and then the motor is started to drive the rotating rod to rotate, and the rotation of the rotating rod drives the stirring rod to rotate, so that the buffer solution and the sodium heparin are uniformly mixed, and at this time, the sodium heparin will separate the impurities contained, and then be salvaged by the salvaging net. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is the overall structure diagram of the utility model;

[0021] Figure 2 It is a right side view of the utility model;

[0022] Figure 3 For this utility model Figure 2 A three-dimensional schematic diagram of the cross section at AA in the middle;

[0023] Figure 4 It is a schematic diagram of the cleaning component of the utility model;

[0024] Figure 5 It is a schematic diagram of the mobile component of the utility model.

[0025] Description of the numbers in the figure:

[0026] 1. Tank body; 2. De-impurity mechanism; 3. Cleaning assembly; 4. Filter assembly; 5. Moving assembly; 6. Fixed assembly; 201. Sealing cover; 202. Feed inlet; 203. Motor; 204. Rotating rod; 205. Stirring rod; 206. Rotating ring; 207. Salvage net; 208. Discharge port; 301. Fixed ring; 302. Hydraulic rod; 303. Support plate; 401. Isolation plate; 402. Solenoid valve; 403. Filter net; 501. Support leg; 502. Universal wheel; 601. Extension plate; 602. Fixed plate; 603. Threaded column; 604. Slide; 605. Fixed block; 7. Extension port; 8. Filter bucket; 9. Anti-sliding block. DETAILED DESCRIPTION

[0027] In order to make the purpose, technical solution and advantages of the utility model more clear, the utility model is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the utility model and are not used to limit the utility model.

[0028] In the description of the present invention, it should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention. In addition, in the description of the present invention, "multiple" means two or more, unless otherwise clearly and specifically defined.

[0029] See also Figure 1-5 The utility model provides a technical solution: a crude heparin sodium impurity removal device, comprising a tank body 1, a impurity removal mechanism 2 is arranged on one side of the tank body 1, a cleaning component 3 is arranged on one side of the tank body 1, a filtering component 4 is arranged at the bottom of the tank body 1, a moving component 5 is arranged at the bottom of the cleaning component 3, and a fixed component 6 is arranged on one side of the moving component 5;

[0030] The impurity removal mechanism 2 includes a sealing cover 201, a feed port 202, a motor 203, a rotating rod 204, a stirring rod 205, a rotating ring 206, a salvaging net 207 and a discharge port 208. The sealing cover 201 is plugged into the top of the tank body 1, the feed port 202 is arranged at the top of the sealing cover 201, the motor 203 is bolted to the top of the sealing cover 201, the rotating rod 204 is fixedly connected to the output end of the motor 203, a plurality of stirring rods 205 are fixedly connected to one side of the rotating rod 204, the rotating ring 206 is rotatably connected to one side of the stirring rod 205, a plurality of salvaging nets 207 are fixedly connected to one side of the rotating ring 206, and the discharge port 208 is arranged at the bottom of the tank body 1.

[0031] In this embodiment: by setting the impurity removal mechanism 2, when in use, the impurity removal mechanism 2 can stir the heparin sodium mixed with the buffer solution, so that the buffer solution and the heparin sodium are evenly mixed, and the impurities contained in the heparin sodium are separated, and then the impurities can be salvaged. By setting the cleaning component, the impurity removal mechanism 2 can be cleaned more conveniently when in use. By setting the filtering component 4, the heparin sodium can be filtered again when in use to increase the impurity removal effect. By setting the moving component 5, the tank body 1 can be moved conveniently when in use. By setting the fixing component 6, the tank body 1 can be moved conveniently when in use. The tank body 1 can be fixed to prevent the tank body 1 from moving when in use. By setting a sealing cover 201, a feed port 202, a motor 203, a rotating rod 204, a stirring rod 205, a rotating ring 206, a salvaging net 207 and a feed port 208, a buffer solution and sodium heparin are added into the tank body 1 through the feed port 202 when in use, and then the motor 203 is started to drive the rotating rod 204 to rotate. The rotation of the rotating rod 204 drives the stirring rod 205 to rotate, so that the buffer solution and sodium heparin are evenly mixed. At this time, the sodium heparin will separate the impurities contained therein, and then be salvaged by the salvaging net 207.

[0032] As a technical optimization solution of the utility model, the cleaning assembly 3 includes a fixing ring 301, a hydraulic rod 302 and a support plate 303. The fixing ring 301 is fixedly connected to one side of the tank body 1, and multiple hydraulic rods 302 are bolted to the top of the fixing ring 301. Multiple support plates 303 are fixedly connected to one side of the sealing cover 201 and are respectively bolted to the multiple hydraulic rods 302.

[0033] In this embodiment: by providing a fixing ring 301, a hydraulic rod 302 and a support plate 303, when the hydraulic rod 302 is started in use, the support plate 303 can be pushed upward, and the sealing cover 201 can be driven upward, thereby opening the tank body 1 and facilitating cleaning of the interior of the tank body 1.

[0034] As a technical optimization solution of the utility model, the filter assembly 4 includes an isolation plate 401, a solenoid valve 402 and a filter screen 403. The isolation plate 401 is bolted to the inside of the tank body 1, the solenoid valve 402 is arranged on one side of the isolation plate 401, and the two filter screens 403 are bolted to the bottom of the tank body 1.

[0035] In this embodiment, by providing an isolation plate 401, a solenoid valve 402 and a filter 403, when heparin sodium and a buffer solution are mixed and impurities are generated, the solenoid valve 402 is opened to allow the heparin sodium to be filtered again through the multiple filter 403, thereby increasing the effect of removing impurities.

[0036] As a technical optimization solution of the present invention, the mobile component 5 includes support legs 501 and universal wheels 502 . The multiple support legs 501 are fixedly connected to the bottom of the fixed ring 301 , and the universal wheels 502 are arranged at the bottom of the support legs 501 .

[0037] In this embodiment, by providing the support legs 501 and the universal wheels 502 , the support legs 501 and the universal wheels 502 can increase the flexibility of the tank body 1 during use.

[0038] As a technical optimization solution of the utility model, the fixing assembly 6 includes an extension plate 601, a fixing plate 602, a threaded column 603, a slide groove 604 and a fixing block 605. The extension plate 601 is fixedly connected to one side of the support leg 501, the fixing plate 602 is fixedly connected to one side of the support leg 501, the threaded column 603 is rotatably connected between the extension plate 601 and the fixing plate 602, the slide groove 604 is opened on one side of the support leg 501, and the fixing block 605 is slidably connected to the inside of the slide groove 604 and is threadedly connected to the threaded column 603.

[0039] In this embodiment: by setting an extension plate 601, a fixing plate 602, a threaded column 603, a slide groove 604 and a fixing block 605, rotating the threaded column 603 during use can drive the fixing block 605 to slide inside the slide groove 604, thereby fixing the tank body 1 against the ground.

[0040] As a technical optimization solution of the present invention, an expansion port 7 is provided at the top of the feed port 202 .

[0041] In this embodiment, by providing the expansion port 7, the expansion port 7 can expand the feeding area of ​​the feeding port 202 when in use, which is convenient to use.

[0042] As a technical optimization solution of the present invention, a filter bucket 8 is provided inside the feed inlet 202 .

[0043] In this embodiment, by providing the filter bucket 8, the filter bucket 8 can first perform a simple filtration on the heparin sodium when in use.

[0044] As a technical optimization solution of the present utility model, an anti-sliding block 9 is fixedly connected to the bottom of the fixed block 605 .

[0045] In this embodiment, by providing the anti-sliding block 9, the anti-sliding block 9 can increase the fixing effect of the fixing block 605 when in use.

[0046] Working principle: first, when in use, add buffer solution and sodium heparin into the tank body 1 through the feed port 202, then start the motor 203 to drive the rotating rod 204 to rotate, and the rotating rod 204 rotates to drive the stirring rod 205 to rotate, so that the buffer solution and sodium heparin are evenly mixed. At this time, the sodium heparin will separate the impurities contained in it, and then be salvaged by the salvage net 207. Starting the hydraulic rod 302 can push the support plate 303 to move upward, drive the sealing cover 201 to move upward, so as to open the tank body 1, and facilitate the cleaning of the interior of the tank body 1. When the sodium heparin and the buffer solution are mixed and impurities are generated, the solenoid valve 402 is opened to allow the sodium heparin to be filtered through the multiple filter nets 403 again, thereby increasing the impurity removal effect. The support legs 501 and the universal wheels 502 can increase the flexibility of the tank body 1, and rotating the threaded column 603 can drive the fixed block 605 to slide inside the slide groove 604, thereby fixing the tank body 1 against the ground.

[0047] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A crude heparin sodium impurity removal device, comprising a tank (1), characterized in that: A cleaning mechanism (2) is provided on one side of the tank body (1), a cleaning assembly (3) is provided on one side of the tank body (1), a filtering assembly (4) is provided at the bottom of the tank body (1), a moving assembly (5) is provided at the bottom of the cleaning assembly (3), and a fixing assembly (6) is provided on one side of the moving assembly (5); The impurity removal mechanism (2) comprises a sealing cover (201), a material inlet (202), a motor (203), a rotating rod (204), a stirring rod (205), a rotating ring (206), a salvaging net (207) and a material outlet (208); the sealing cover (201) is plugged into the top of the tank body (1); the material inlet (202) is arranged at the top of the sealing cover (201); the motor (203) is bolted to the top of the sealing cover (201); the rotating rod (204) is fixedly connected to the output end of the motor (203); a plurality of stirring rods (205) are fixedly connected to one side of the rotating rod (204); the rotating ring (206) is rotatably connected to one side of the stirring rod (205); a plurality of salvaging nets (207) are fixedly connected to one side of the rotating ring (206); and the material outlet (208) is arranged at the bottom of the tank body (1).

2. A crude heparin sodium impurity removal device according to claim 1, characterized in that: The cleaning assembly (3) comprises a fixing ring (301), a hydraulic rod (302) and a support plate (303); the fixing ring (301) is fixedly connected to one side of the tank body (1); a plurality of the hydraulic rods (302) are bolted to the top of the fixing ring (301); and a plurality of the support plates (303) are fixedly connected to one side of the sealing cover (201) and are respectively bolted to the plurality of hydraulic rods (302).

3. A crude heparin sodium impurity removal device according to claim 1, characterized in that: The filter assembly (4) comprises an isolation plate (401), a solenoid valve (402) and a filter screen (403); the isolation plate (401) is bolted to the inside of the tank body (1); the solenoid valve (402) is arranged on one side of the isolation plate (401); and the two filter screens (403) are bolted to the bottom of the tank body (1).

4. A crude heparin sodium impurity removal device according to claim 2, characterized in that: The moving assembly (5) comprises a supporting leg (501) and a universal wheel (502); a plurality of the supporting legs (501) are fixedly connected to the bottom of the fixing ring (301); and the universal wheel (502) is arranged at the bottom of the supporting leg (501).

5. A crude heparin sodium impurity removal device according to claim 4, characterized in that: The fixing assembly (6) comprises an extension plate (601), a fixing plate (602), a threaded column (603), a slide groove (604) and a fixing block (605), wherein the extension plate (601) is fixedly connected to one side of the supporting leg (501), the fixing plate (602) is fixedly connected to one side of the supporting leg (501), the threaded column (603) is rotatably connected between the extension plate (601) and the fixing plate (602), the slide groove (604) is opened on one side of the supporting leg (501), and the fixing block (605) is slidably connected to the inside of the slide groove (604) and is threadedly connected to the threaded column (603).

6. A crude heparin sodium impurity removal device according to claim 1, characterized in that: The top of the feed inlet (202) is provided with an expansion opening (7).

7. A crude heparin sodium impurity removal device according to claim 1, characterized in that: A filter hopper (8) is provided inside the feed inlet (202).

8. The device for removing impurities from crude heparin sodium according to claim 5, characterized in that: The bottom of the fixed block (605) is fixedly connected with an anti-sliding block (9).

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