Advancing equipment convenient for magnetic bead separation

Abstract

The utility model discloses advancing equipment convenient for magnetic bead separation, which comprises a reciprocating mechanism, a sliding plate, a magnetic mechanism and an incubation seat, the reciprocating mechanism is fixedly connected with a guide bracket, an inclined plate extends on the guide bracket, the sliding plate is connected with the reciprocating mechanism in a sliding manner, a mounting groove is formed in the sliding plate in a penetrating manner, and the magnetic mechanism is arranged in the mounting groove; the magnetic mechanism comprises a lifting plate, a plurality of magnets arranged at intervals are arranged on the lifting plate, a connecting support is arranged on the lifting plate, rollers are rotationally connected to the connecting support, the incubation base is installed on the sliding plate, a plurality of containing grooves arranged at intervals are formed in the incubation base, a plurality of groove positions are formed in the bottoms of the containing grooves in a penetrating mode, and the magnets penetrate through the groove positions; a reagent is placed in the containing groove, an elastic assembly is installed on the incubation base and penetrates through the lifting plate, and the lifting plate is connected with the elastic assembly. The utility model provides advancing equipment convenient for magnetic bead separation, and the influence of a magnetic mechanism during magnetic bead recovery is reduced.

Description

Technical Field

[0001] The utility model relates to the field of traveling equipment, in particular to a traveling equipment which is convenient for separating magnetic beads. Background Art

[0002] In the field of POCT chemiluminescent immunoassay diagnostic automation, immunomagnetic bead separation technology is used to use nano- or micron-sized magnetic beads with antigens or antibodies coupled to their surfaces as separation media. The target substance is captured through a highly specific reaction between the antigen and the antibody, and then an external magnetic field is used to separate the target substance from other substances in the mixture, thereby achieving the purpose of separation, enrichment, and purification.

[0003] The magnetic beads used in the experiment need to be placed in the reaction tank of the reagent. The magnetic mechanism adsorbs the magnetic beads in the reaction tank onto the inner wall of the reaction tank, and the cleaning solution is used to blow and purify the magnetic beads.

[0004] After the above-mentioned magnetic beads are purified, the magnetic beads need to be taken out from the reaction tank. However, the magnetic mechanism adsorbs the magnetic beads on the inner wall of the reaction tank, which affects the recovery effect of the magnetic beads. Utility Model Content

[0005] The utility model aims to provide a traveling device which is convenient for separating magnetic beads and reduces the influence of the magnetic mechanism when recovering the magnetic beads.

[0006] The technical solution adopted by a traveling device for facilitating magnetic bead separation disclosed in the utility model is:

[0007] It includes a reciprocating mechanism, a slide plate, a magnetic mechanism and an incubation seat, the reciprocating mechanism is fixedly connected with a guide bracket, the guide bracket is extended with an inclined plate, the slide plate is slidably connected to the reciprocating mechanism, the slide plate is provided with a mounting groove, the magnetic mechanism is placed in the mounting groove, the magnetic mechanism includes a lifting plate, the lifting plate is provided with a plurality of magnets arranged at intervals, the lifting plate is provided with a connecting bracket, the connecting bracket is rotatably connected with a roller, the roller is close to the inclined surface of the inclined plate, the incubation seat is installed on the slide plate, the incubation seat is provided with a plurality of receiving grooves arranged at intervals, the bottom of the receiving groove is provided with a plurality of slots, the magnet passes through the slots, the reagent is placed in the receiving groove, the magnet is close to the reagent storage slot, an elastic component is installed on the incubation seat, the elastic component passes through the lifting plate, and the lifting plate is connected to the elastic component.

[0008] As a preferred embodiment, the reciprocating mechanism includes a base and a belt, one end of the base is fixedly connected to a motor, the other end of the base is rotatably connected to a pulley, the belt is sleeved on the pulley and the output shaft of the motor, the belt is fixedly connected to a first connecting member, and the first connecting member is fixedly connected to the slide.

[0009] As a preferred solution, both sides of the base are fixedly connected with connecting pieces, and both sides of the slide plate are fixedly connected with polished rods, and the polished rods are slidably connected to the connecting pieces.

[0010] As a preferred solution, a notch is provided on the base, the guide bracket is located on the inner wall of the notch, the other end of the base is slidably connected to an adjustment plate, a fixing piece is provided on the adjustment plate, one end of the fixing piece passes through the adjustment plate, one end of the fixing piece is rotatably connected to the other end of the base, and the pulley is rotatably connected to the adjustment plate.

[0011] As a preferred solution, it also includes a bearing seat, the base is slidably connected to the top of the bearing seat, and a second connecting piece is fixedly connected to the belt, and the second connecting piece is fixedly connected to the bearing seat.

[0012] As a preferred solution, there are two inclined plates, which are located on both sides of the guide bracket. A notch is provided on the guide bracket, and the two inclined plates are located on both sides of the notch. The belt is located in the notch. There are two rollers, and two connecting columns extend from the connecting bracket. The two connecting columns are respectively close to both sides of the connecting bracket. The belt is located between the two connecting columns, and the roller is rotatably connected to the connecting columns.

[0013] As a preferred solution, the elastic component includes a sliding rod and a limiting member, the sliding rod is fixedly connected to the incubation seat, one end of the sliding rod passes through the lifting plate, the limiting member is sleeved on one end of the sliding rod, and a spring is sleeved on the outer side of the sliding rod, and the two ends of the spring respectively touch the lifting plate and the limiting member.

[0014] As a preferred solution, the cross section of the magnet is tile-shaped, two adjacent magnets are opposed to each other, and a cylindrical space is formed between the two adjacent magnets.

[0015] As a preferred solution, an expansion slot is provided in the receiving slot, a Hct detection device is installed in the expansion slot, and one of the storage slots on the reagent is placed in the Hct detection device.

[0016] The beneficial effects of a traveling device for facilitating magnetic bead separation disclosed in the utility model are:

[0017] When the magnetic beads in the storage tank need to be recovered after purification, the slide plate is driven by the reciprocating mechanism to slide on the reciprocating mechanism to one end of the reciprocating mechanism. During the sliding of the slide plate on the reciprocating mechanism, the mounting groove of the slide plate carries the connecting bracket of the magnetic mechanism close to the guide bracket, so that the roller of the connecting bracket slides on the inclined surface of the inclined plate, and the inclined plate of the guide bracket pulls the connecting bracket through the roller, thereby pulling the lifting plate down, and the magnet in the receiving tank slides out of the slot position, so that the magnet is away from the storage tank of the reagent, and the magnetic beads in the storage tank lose the adsorption of the magnet, which is convenient for the external unloading mechanism to recover the magnetic beads in the storage tank;

[0018] When the magnetic beads in the storage tank are recovered, the reciprocating mechanism drives the slide plate to slide to the other end of the reciprocating mechanism. During the sliding of the slide plate on the reciprocating mechanism, the connecting bracket moves away from the guide bracket, the roller of the connecting bracket loses the pull of the inclined plate of the guide bracket, and the elastic component pushes the lifting plate to rise and reset, allowing the magnet to slide into the slot, the magnet can extend into the receiving slot, and the magnet is close to the storage tank of the reagent; the slide plate drives the incubation seat to move to the bottom of the external loading mechanism, and the external loading mechanism puts the magnetic beads to be purified into the storage tank; the reciprocating mechanism drives the slide plate to slide on the reciprocating mechanism to the middle of the reciprocating mechanism, the magnet adsorbs the magnetic beads on the inner wall of the storage tank, and uses external cleaning fluid for blowing and purification. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 The utility model is a structural schematic diagram of a traveling device for facilitating magnetic bead separation.

[0020] Figure 2 The utility model is a reagent installation schematic diagram of a traveling device for facilitating magnetic bead separation.

[0021] Figure 3 The utility model is a schematic diagram of the reciprocating mechanism structure of a traveling device for facilitating magnetic bead separation.

[0022] Figure 4 The utility model is a schematic diagram of the magnetic mechanism structure of a traveling device which is convenient for separating magnetic beads.

[0023] Figure 5 The utility model is a schematic diagram of the installation of an incubation seat of a traveling device for facilitating magnetic bead separation. DETAILED DESCRIPTION

[0024] The present invention is further described and illustrated below in conjunction with specific embodiments and accompanying drawings:

[0025] Please refer to Figure 1 and Figure 2 .

[0026] The utility model discloses a traveling device for facilitating magnetic bead separation, which is used for placing a reagent 1. The reagent 1 is provided with a plurality of placement slots, in which magnetic beads are placed. The reagent 1 begins to have a through hole, which is close to one end of the reagent 1, in which a reaction cup 11 is installed.

[0027] Please refer to Figure 1-Figure 3 .

[0028] The traveling device includes a bearing seat 2, a reciprocating mechanism 3, a slide plate 4, a magnetic mechanism 5 and an incubation seat 6.

[0029] The bearing seat 2 is used to be installed on the external expansion equipment, and the reciprocating mechanism 3 is installed on the top of the bearing seat 2.

[0030] Please refer to Figure 2-Figure 4 .

[0031] The reciprocating mechanism 3 includes a base 31, a guide bracket 34 and a belt 32; the base 31 is slidably connected to the top of the bearing seat 2, one end of the base 31 is fixedly connected to a motor 311, and a driving wheel is fixedly connected to the output shaft of the motor 311; the other end of the base 31 is slidably connected to an adjustment plate 312, and a fixing piece is provided on the adjustment plate 312. In this embodiment, the fixing piece is preferably a screw, one end of the fixing piece passes through the adjustment plate 312, one end of the fixing piece is rotatably connected to the other end of the base 31, and the other end of the base 31 is rotatably connected to a pulley 313, and the pulley 313 is rotatably connected to the adjustment plate 312;

[0032] Furthermore, the belt 32 is sleeved on the pulley 313 and the output shaft of the motor 311, and the belt 32 wraps the base 31 inside. By rotating the fixing piece, the adjustment plate 312 is allowed to slide a certain distance on the base 31, and the distance between the adjustment plate 312 and the base 31 is controlled to adjust the preload force of the belt 32; the belt 32 is fixedly connected with a first connecting piece, and the first connecting piece is located above the base 31; the belt 32 is fixedly connected with a second connecting piece, and the second connecting piece is located below the base 31, and the second connecting piece is fixedly connected with the bearing seat 2;

[0033] Furthermore, connecting parts 33 are fixedly connected on both sides of the base 31; a notch is provided on the base 31, the notch runs through the base 31, the notch reserves operating space for the elastic component 62, and reduces the height of the device; the guide bracket 34 is fixedly connected to the inner wall of the notch, and an inclined plate 341 extends from the guide bracket 34. In this embodiment, two inclined plates 341 are preferably provided, and the two inclined plates 341 are respectively located on both sides of the guide bracket 34. A notch is provided in the middle of the guide bracket 34, and the two inclined plates 341 are respectively located on both sides of the notch, and the inclined surface of the inclined plate 341 faces the notch. The belt 32 is located in the notch, and the notch is used to avoid contact between the guide bracket 34 and the belt 32.

[0034] Please refer to Figure 2 , Figure 4 and Figure 5 .

[0035] The slide plate 4 is slidably connected to the reciprocating mechanism 3, and both sides of the slide plate 4 are fixedly connected with a polished rod 41, the polished rod 41 is slidably connected to the connecting member 33, and the first connecting member is fixedly connected to the bottom of the slide plate 4; a mounting groove is opened through the slide plate 4, the mounting groove passes through the slide plate 4, and the magnetic mechanism 5 is placed in the mounting groove;

[0036] The magnetic mechanism 5 includes a lifting plate 51, which is placed in the mounting groove. A plurality of magnets 511 arranged at intervals are provided on the lifting plate 51. The plurality of magnets 511 arranged at intervals form two rows of magnets 511. The cross section of the magnets 511 is tile-shaped. Two adjacent magnets 511 are opposed to each other, and a cylindrical space is formed between the two adjacent magnets 511.

[0037] Further, a connection bracket 52 is fixedly connected to the bottom of the lifting plate 51, and a roller 521 is rotatably connected to the connection bracket 52. In this embodiment, preferably, there are two rollers 521, and two connection columns extend from the connection bracket 52. The two connection columns are respectively close to the two sides of the connection bracket 52, and the belt 32 is located between the two connection columns. The roller 521 is rotatably connected to the connection column, and the roller 521 is close to the inclined surface of the inclined plate 341;

[0038] The bottom of the incubation seat 6 is fixedly connected to the top of the slide 4, and a plurality of receiving grooves 61 arranged at intervals are provided on the top of the incubation seat 6. A plurality of slots 611 are provided through the bottom of the receiving groove 61, and the magnet 511 passes through the slot 611. An expansion groove is provided in the receiving groove 61, and a Hct detection device 612 is installed in the expansion groove; the reagent 1 is placed in the receiving groove 61, one of the storage grooves on the reagent 1 is placed in the Hct detection device 612, and the other storage groove of the reagent 1 is placed in the cylindrical space formed between the two magnets 511;

[0039] An elastic component 62 is installed on the incubation seat 6. In this embodiment, two elastic components 62 are preferably provided. The elastic component 62 passes through the lifting plate 51, and the lifting plate 51 is connected to the elastic component 62; the elastic component 62 includes a sliding rod 621 and a limiting member 623. The two sliding rods 621 are fixedly connected to the incubation seat 6, one end of the sliding rod 621 passes through the lifting plate 51, the limiting member 623 is sleeved on one end of the sliding rod 621, and a spring 622 is sleeved on the outer side of the sliding rod 621, and the two ends of the spring 622 respectively touch the lifting plate 51 and the limiting member 623.

[0040] Please refer to Figure 1-Figure 5 .

[0041] When the magnetic beads in the storage tank need to be recovered after purification, the motor 311 rotates forward to drive the belt 32 to move. During the movement, the belt 32 pulls the slide plate 4 through the first connecting member to slide a certain distance toward one end of the base 31 on the connecting member 33 by relying on the light rod 41. The installation groove of the slide plate 4 carries the connecting bracket 52 of the magnetic mechanism 5 close to the guide bracket 34, so that the roller 521 of the connecting bracket 52 slides on the inclined surface of the inclined plate 341, and the inclined plate 341 of the guide bracket 34 pulls the connecting bracket 52 through the roller 521. The connecting bracket 52 pulls the lifting plate 51 down to make the magnet 511 slide out of the slot 611, so that the magnet 511 is away from the storage tank of the reagent 1, and the magnetic beads in the storage tank lose the adsorption of the magnet 511, which is convenient for the external unloading mechanism to recover the magnetic beads in the storage tank;

[0042] When the magnetic beads in the storage tank are recovered and need to be filled with magnetic beads to be purified, the motor 311 reverses to drive the belt 32 to move. During the movement, the belt 32 pulls the slide plate 4 through the first connecting piece to rely on the light rod 41 to slide a certain distance toward the other end of the base 31 on the connecting piece 33. During the movement, the belt 32 pulls the base 31 on the supporting seat 2 through the second connecting piece to slide, allowing the supporting seat 2 to slide toward one end of the base 31. The supporting seat 2 is fixed to the external expansion device, and the base 31 and the slide plate 4 slide in the same direction at the same time, which can make the slide plate 4 move a longer distance; during the sliding of the slide plate 4 on the reciprocating mechanism 3, the connecting bracket 52 moves away from the guide bracket 34, and the roller 521 of the connecting bracket 52 loses the pull of the inclined plate 341 of the guide bracket 34, and the elastic The component 62 pushes the lifting plate 51 to rise and reset, allowing the magnet 511 to slide into the slot 611. The magnet 511 can extend into the receiving slot 61, and the magnet 511 is close to the storage slot of the reagent 1; the slide plate 4 drives the incubation seat 6 to move to the bottom of the external loading mechanism, and the external loading mechanism puts the magnetic beads to be purified into the storage slot; the motor 311 rotates forward to drive the belt 32 to move, and the belt 32 uses the first connecting piece to drive the slide plate 4 to slide on the connecting piece 33 to the middle of the base 31 by relying on the light rod 41. The belt 32 uses the second connecting piece to drive the base 31 to slide on the supporting seat 2, allowing the supporting seat 2 to slide close to the other end of the base 31, so that the base 31 and the slide plate 4 are reset, and the magnet 511 adsorbs the magnetic beads on the inner wall of the storage slot, and then uses the external cleaning fluid to blow and purify.

[0043] The utility model provides a traveling device that is convenient for magnetic bead separation. When the magnetic beads in the storage tank need to be recovered after purification, the slide plate is driven by the reciprocating mechanism to slide on the reciprocating mechanism to one end of the reciprocating mechanism. During the sliding of the slide plate on the reciprocating mechanism, the installation groove of the slide plate carries the connecting bracket of the magnetic mechanism close to the guide bracket, so that the roller of the connecting bracket slides on the inclined surface of the inclined plate, and the inclined plate of the guide bracket pulls the connecting bracket through the roller, thereby pulling the lifting plate down, and the magnet in the receiving tank slides out of the slot position, so that the magnet is away from the storage tank of the reagent, and the magnetic beads in the storage tank lose the adsorption of the magnet, which is convenient for the external unloading mechanism to recover the magnetic beads in the storage tank.

[0044] When the magnetic beads in the storage tank are recovered, the reciprocating mechanism drives the slide plate to slide to the other end of the reciprocating mechanism. During the sliding of the slide plate on the reciprocating mechanism, the connecting bracket moves away from the guide bracket, the roller of the connecting bracket loses the pull of the inclined plate of the guide bracket, and the elastic component pushes the lifting plate to rise and reset, allowing the magnet to slide into the slot, the magnet can extend into the receiving slot, and the magnet is close to the storage tank of the reagent; the slide plate drives the incubation seat to move to the bottom of the external loading mechanism, and the external loading mechanism puts the magnetic beads to be purified into the storage tank; the reciprocating mechanism drives the slide plate to slide on the reciprocating mechanism to the middle of the reciprocating mechanism, the magnet adsorbs the magnetic beads on the inner wall of the storage tank, and uses external cleaning fluid for blowing and purification.

[0045] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the utility model, rather than to limit the protection scope of the utility model. Although the utility model has been described in detail with reference to the preferred embodiments, ordinary technicians in this field should understand that the technical solution of the utility model can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the utility model.

Claims

1. A traveling device for facilitating magnetic bead separation, used for placing reagents, wherein the reagents are provided with a plurality of storage slots, and magnetic beads are placed in the storage slots, characterized in that: It includes a reciprocating mechanism, a slide plate, a magnetic mechanism and an incubation seat; A guide bracket is fixedly connected to the reciprocating mechanism, and an inclined plate extends from the guide bracket; The slide plate is slidably connected to the reciprocating mechanism, a mounting groove is formed through the slide plate, and the magnetic mechanism is placed in the mounting groove; The magnetic mechanism comprises a lifting plate, a plurality of magnets arranged at intervals are arranged on the lifting plate, a connecting bracket is arranged on the lifting plate, a roller is rotatably connected to the connecting bracket, and the roller is close to the inclined surface of the inclined plate; The incubation seat is installed on the slide, and a plurality of receiving grooves arranged at intervals are provided on the incubation seat. A plurality of slots are penetrated through the bottom of the receiving grooves, and the magnet passes through the slots. The reagent is placed in the receiving groove, and the magnet is close to the reagent storage groove. An elastic component is installed on the incubation seat, and the elastic component passes through the lifting plate, and the lifting plate is connected to the elastic component.

2. A traveling device for facilitating magnetic bead separation as claimed in claim 1, characterized in that: The reciprocating mechanism includes a base and a belt, one end of the base is fixedly connected to a motor, the other end of the base is rotatably connected to a pulley, the belt is sleeved on the pulley and the output shaft of the motor, the belt is fixedly connected to a first connecting member, and the first connecting member is fixedly connected to the slide.

3. A traveling device for facilitating magnetic bead separation as claimed in claim 2, characterized in that: Both sides of the base are fixedly connected with connecting pieces, and both sides of the slide plate are fixedly connected with polished rods, and the polished rods are slidably connected with the connecting pieces.

4. A traveling device for facilitating magnetic bead separation as claimed in claim 3, characterized in that: A notch is provided on the base, and the guide bracket is located on the inner wall of the notch. The other end of the base is slidably connected to an adjustment plate, and a fixing piece is provided on the adjustment plate. One end of the fixing piece passes through the adjustment plate, and one end of the fixing piece is rotatably connected to the other end of the base, and the pulley is rotatably connected to the adjustment plate.

5. A traveling device for facilitating magnetic bead separation as claimed in claim 4, characterized in that: It also includes a bearing seat, the base is slidably connected to the top of the bearing seat, and a second connecting piece is fixedly connected to the belt, and the second connecting piece is fixedly connected to the bearing seat.

6. A traveling device for facilitating magnetic bead separation as claimed in claim 5, characterized in that: There are two inclined plates, which are located on both sides of the guide bracket. A notch is provided on the guide bracket, and the two inclined plates are located on both sides of the notch. The belt is located in the notch. There are two rollers, and two connecting columns extend from the connecting bracket. The two connecting columns are respectively close to both sides of the connecting bracket. The belt is located between the two connecting columns, and the roller is rotatably connected to the connecting columns.

7. A traveling device for facilitating magnetic bead separation as claimed in any one of claims 1 to 6, characterized in that: The elastic component includes a sliding rod and a limiting member, the sliding rod is fixedly connected to the incubation seat, one end of the sliding rod passes through the lifting plate, the limiting member is sleeved on one end of the sliding rod, a spring is sleeved on the outer side of the sliding rod, and the two ends of the spring respectively touch the lifting plate and the limiting member.

8. A traveling device for facilitating magnetic bead separation as claimed in claim 7, characterized in that: The cross section of the magnet is in the shape of a tile, two adjacent magnets are opposed to each other, and a cylindrical space is formed between the two adjacent magnets.

9. A traveling device for facilitating magnetic bead separation as claimed in claim 8, characterized in that: An expansion slot is provided in the receiving slot, a Hct detection device is installed in the expansion slot, and one of the storage slots on the reagent is placed in the Hct detection device.

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