Novel double-wheel-disc assembly line type affinity column treatment device

Abstract

A novel double-wheel-disc assembly line type affinity column treatment device comprises a conveying system, a collecting system, a leaching system and a cap removing system, the cap removing system comprises a vertical frame and a pressing mechanism on the upper portion of the vertical frame, and a cap removing mechanism is further arranged on one side of the vertical frame; the cap removing mechanism comprises a sliding block capable of vertically sliding, two clamping blocks capable of transversely sliding are horizontally and oppositely arranged on one side of the sliding block, the two clamping blocks are both elastically connected with the sliding block, and the directions of the two clamping blocks subjected to elastic force face each other. Clamping plates are further vertically arranged on the two clamping blocks, the lower ends of the two clamping plates are connected with the two clamping blocks respectively, the upper ends of the two clamping plates are bent towards each other, the two clamping blocks can be driven to move upwards when the sliding block moves upwards, the two clamping plates can cross over the cap under the elastic effect and are clamped to the two sides between the cap and the affinity column, and the cap is taken away from the affinity column when the sliding block moves downwards, so that the uncapping work is completed. And the cap can be removed only by controlling the sliding block to move up and down, so that the cap removing work can be simpler and more convenient.

Description

Technical Field

[0001] The utility model relates to the technical field of biological experimental instruments and equipment, in particular to a novel double-wheel assembly line affinity column processing device. Background Art

[0002] The immunoaffinity column is a biological experimental technology used to separate or enrich specific proteins or other molecules. The application document with application number CN202223181981.3 in the patent library discloses an immunoaffinity operator, which completes the sequential transportation of the immunoaffinity column through a roulette-type sample rotating device, and completes the collection of the eluate through a elution device and a roulette-type collection rotating device coordinated with the sample rotating device.

[0003] At the same time, before the elution work is carried out, the cap at the lower end of the immunoaffinity column needs to be removed to ensure that the eluent (waste liquid) and the eluted product can flow out smoothly. However, the mechanism for removing the cap is driven by an electromagnet, and the clamp used for removing the cap includes a vertical plate and two horizontal clamping plates. When removing the cap, the electromagnet needs to drive the clamp to move, and the lower end of the immunoaffinity column is clamped between the two supporting plates, and the cap is removed by moving the clamping plate downward. This kind of cap removal method, on the one hand, requires coordination of the vertical and lateral movement of the clamp, which makes the cap removal work difficult to control and has high requirements on the clamping position of the clamp. On the other hand, due to the fixed position of the two clamping plates, it can only be used for the cap removal work of a single specification. Utility Model Content

[0004] In order to solve the technical problems existing in the above-mentioned background technology, the utility model provides a novel double-wheel assembly line affinity column processing device.

[0005] The technical solution of this utility model is as follows:

[0006] A novel double-wheel assembly line affinity column processing device includes a wheel-type transport system and a corresponding wheel-type collection system, wherein the affinity column and the collection tube can be transported along the transport system and the collection system respectively, and also includes a rinsing system and a capping system, wherein the capping system is configured to remove the cap at the lower end of the affinity column on the transport system, and the rinsing system is configured to elute the sample in the affinity column into the collection tube on the collection system.

[0007] As for the structure of the decapping system, it includes a stand and a clamping mechanism on its upper part, and the clamping mechanism can clamp the upper end of the affinity column on the transport system. One side of the stand is also provided with a decapping mechanism that can remove the cap at the lower end of the affinity column.

[0008] The core technical concept of the present invention is that the cap-removing mechanism comprises a slider capable of vertical sliding, and two clamping blocks capable of horizontal sliding are arranged horizontally on one side of the slider, and the two clamping blocks are elastically connected to the slider and are subjected to elastic forces in the directions facing each other. Clamping plates are also vertically arranged on the two clamping blocks, and the lower ends of the two clamping plates are respectively connected to the two clamping blocks, and the upper ends are bent toward each other. The upward movement of the slider can drive the two clamping blocks to move upward, and the two clamping plates can pass over the cap and be clamped on both sides between the cap and the affinity column under the elastic action, and when the slider moves downward, the clamping plates on both sides can bring the cap away from the affinity column to complete the cap-removing work. The cap can be removed by only controlling the up and down movement of the slider, so that the cap-removing work can be carried out more simply and conveniently, and the elastic arrangement of the two clamping blocks makes the cap-removing system applicable to the cap-removing work of caps of multiple specifications, which significantly expands the applicability of the cap-removing system.

[0009] In the novel double-wheel assembly line affinity column processing device as described above, in order to enable the upper ends of the two clamping plates to be better clamped between the cap and the affinity column, thereby enabling it to better complete the cap removal work, a notch is provided in the middle of the bent end of the clamping plate.

[0010] In order to further ensure the clamping effect of the splint, the notch is an arc-shaped structure facing the opposite splint.

[0011] As described above, a novel double-wheel assembly line affinity column processing device, in order to ensure the clamping effect of the clamping plates while allowing the two clamping plates to smoothly pass over the cap and complete the clamping work under the action of elasticity, the uncapping system also includes a guide column vertically arranged below the uncapping mechanism, the upper end diameter of the guide column is smaller than the lower end diameter, and the two clamping blocks are slidably fitted with the guide column.

[0012] In order to make the clamping block slide more smoothly along the guide column, the guide column is configured to include an open section and a closed section at its upper end, the open section has a diameter larger than that of the closed section, and there is an arc transition between the open section and the closed section.

[0013] In order to make the sliding work of the clamping block along the guide column more stable, a notch is provided at the position where the clamping block and the guide column slide and fit.

[0014] In order to ensure the strength of the guide column and prevent the guide column from being affected by rust, the guide column is made of stainless steel.

[0015] As described above, in order to prevent the clamping plate from being affected by rust or other pollution during use and to ensure the service life of the clamping plate, the cap removal mechanism also includes a protective cover buckled on the top of the two clamping blocks, and the protective cover has openings corresponding to the notches on the upper ends of the two clamping plates.

[0016] In order to protect the clamping plate from rust while ensuring its working strength and thus its clamping effect, the clamping plate is made of stainless steel.

[0017] To further protect the splint from rust, it is coated with a rust-resistant coating.

[0018] The beneficial effects of the utility model are as follows: the utility model is a novel double-wheel assembly line affinity column processing device, when the slider moves upward, it can drive the two clamping blocks to move upward, the two clamping plates can cross the cap under the elastic effect and be clamped on both sides between the cap and the affinity column, and when the slider moves downward, the clamping plates on both sides can bring the cap away from the affinity column to complete the uncapping work, and the cap can be removed only by controlling the up and down movement of the slider, so that the uncapping work can be carried out more simply and conveniently, and the elastic arrangement of the two clamping blocks makes the uncapping system suitable for the uncapping work of caps of multiple specifications, which significantly expands the applicability of the uncapping system. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] By reading the detailed description of the preferred embodiment below, the scheme and advantages of the present application will become clear to those skilled in the art. The accompanying drawings are only used to illustrate the preferred embodiment and are not considered to be limiting of the present invention.

[0020] In the attached picture:

[0021] Figure 1 It is a structural schematic diagram of the processing device in the embodiment;

[0022] Figure 2 It is a structural schematic diagram of the cap removal system in the embodiment;

[0023] Figure 3 It is a structural schematic diagram of the cap-removing mechanism in the embodiment;

[0024] Figure 4 It is a structural schematic diagram of the cap-removing mechanism after the protective cover is hidden in the embodiment;

[0025] Figure 5 Schematic diagram of the matching structure between the cap-removing mechanism and the guide column in the embodiment;

[0026] Figure 6 It is a schematic diagram of the sliding cooperation structure between the clamping block and the guide column in the embodiment;

[0027] The components represented by the reference numerals in the figure are:

[0028] 1. Main frame; 2. Transport system; 21. Support plate; 22. Fixed plate; 23. Liquid collecting tank; 3. Rinsing system; 31. Rinsing mechanism; 32. Elution mechanism; 4. Collection system; 5. Cap removal system; 51. Vertical frame; 511. Base; 512. Vertical plate; 513. Horizontal plate; 514. Reinforcement plate; 52. Clamping mechanism; 521. Vertical column; 522. Pressing block; 53. Cap removal mechanism; 531. Driving unit; 532. Executing unit; 5321. Fixed block; 5322. Sliding block; 5323. Clamping block; 5324. Clamping plate; 5325. Protective cover; 54. Guide column. DETAILED DESCRIPTION

[0029] Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings.

[0030] Example

[0031] This embodiment provides a novel dual-wheel assembly line affinity column processing device, see Figure 1 , including a roulette-type transport system 2 and a corresponding roulette-type collection system 4, the affinity column and the collection tube can be transported along the transport system 2 and the collection system 4 respectively, the processing device (the above-mentioned novel double-roulette assembly line affinity column processing device) also includes a leaching system 3 and a capping system 5, wherein the capping system 5 is configured to remove the cap at the lower end of the affinity column on the transport system 2, and the leaching system 3 is configured to elute the sample in the affinity column into the collection tube on the collection system 4. The structure of the processing device is described in detail below.

[0032] In this embodiment, the processing device also includes a main frame 1, and the transportation system 2, the collection system 4, the elution system 3 and the cap removal system 5 are all arranged on the main frame 1, wherein the transportation system 2 includes a support plate 21 and a fixed plate 22 coaxially arranged up and down, and the outer circle of the support plate 21 and the fixed plate 22 is circumferentially provided with corresponding fixing holes one by one, and the affinity column can be vertically placed in two corresponding fixing holes.

[0033] In order to collect the waste liquid generated during the elution process, an annular liquid collecting tank 23 is provided below the fixed plate 22, and the liquid collecting tank 23 is located directly below the fixed hole.

[0034] The transport system 2 further comprises a first driving machine, and the first driving machine can drive the supporting plate 21 and the fixing plate 22 to rotate synchronously, thereby driving the affinity column to rotate.

[0035] In this embodiment, the collection system 4 includes a collection plate rotatably arranged below one side of the fixed plate 22. A plurality of placement openings are opened circumferentially on the collection plate. The number of the placement openings is the same as the number of fixed holes on the support plate 21 or the fixed plate 22. The collection tube can be placed in the placement opening. The collection system 4 also includes a second driving motor, and the collection plate can be driven to rotate by the second driving motor. At the same time, during the rotation of the fixed plate 22 and the collection plate, the affinity columns and the collection tubes can correspond one by one, and the eluates of the plurality of affinity columns can be collected one by one into the plurality of collection tubes.

[0036] In this embodiment, the rinsing mechanism 31 includes a rinsing mechanism 31 and an eluting mechanism 32 arranged on one side of the transportation system 2, wherein the rinsing mechanism 31 includes a first bracket arranged on the main frame 1, the first bracket is provided with a first lifting unit, the first lifting unit is provided with a plurality of rinsing parts, the rinsing parts include an air blowing head, a rinsing head and an air blowing rinsing head arranged in sequence along the rotation direction of the support plate 21, and the descent of the first lifting unit can drive the plurality of rinsing parts to respectively press a plurality of adjacent affinity columns.

[0037] The elution mechanism 32 includes a second bracket arranged on the main frame 1, the second bracket is provided with a second lifting unit, the second lifting unit is provided with an elution component, the elution component includes an elution head, and the descent of the second lifting unit can drive the elution head to press the affinity column and inject the elution liquid into the affinity column, and then the collection tube completes the collection of the eluate.

[0038] In this embodiment, combined with Figure 2 The decapping system 5 includes a stand 51 and a clamping mechanism 52 on its upper portion, and the clamping mechanism 52 can clamp the upper end of the affinity column on the transport system 2. A decapping mechanism 53 is also provided on one side of the stand 51 for removing the cap at the lower end of the affinity column.

[0039] As for the structure of the vertical frame 51, it includes a base 511 arranged on the main frame 1, a vertical plate 512 is vertically provided on the upper part of one side of the base 511, a horizontal plate 513 is horizontally provided at the upper end of the plate, and the clamping mechanism 52 is arranged on the horizontal plate 513. In order to ensure the structural strength between the horizontal plate 513 and the vertical plate 512, a reinforcing plate 514 is also provided between the vertical plate 512 and the horizontal plate 513.

[0040] As for the structure of the clamping mechanism 52, it includes a column 521 vertically arranged on the horizontal plate 513, and a pressing block 522 is provided at the upper end of the column 521. When the affinity column is transported by the transportation system 2, the upper end can slide and fit with the pressing block 522, and the clamping work of the affinity column is completed by the pressing block 522, and the capping mechanism 53 is cooperated to complete the removal of the cap at the lower end of the affinity column.

[0041] In order to facilitate the adjustment of the height of the pressing block 522, the column 521 is threadedly connected to the cross plate 513. At the same time, in order to facilitate the adjustment of the clamping position of the pressing block 522, one end of the pressing block 522 is rotatably connected to the column 521 and can fix its own position by a fastening bolt. For example, a fastening bolt can be set at the connection position between the pressing block 522 and the column 521, and the column 521 can be tightened by the fastening bolt to complete the fixation of the position of the pressing block 522.

[0042] As the core technical concept of the present invention, with respect to the structure of the cap removal mechanism 53, Figure 3 and Figure 4 It includes a driving part 531 and an executing part 532 connected thereto, and the driving part 531 can complete the driving work of the executing part 532, and the executing part 532 can complete the removal work of the cap.

[0043] Specifically speaking, the structure of the driving part 531 includes a third driving motor arranged on the base 511, and a vertically arranged driving stud is connected to the upper end thereof. The upper end of the driving stud is rotatably connected to the cross plate 513, and the driving stud can be driven to rotate by the third driving motor. A connecting piece is spirally provided on the driving stud, and the connecting piece is connected to the executing part 532 through the connecting piece. Then, the rotation of the driving stud can drive the connecting piece to rise and fall, thereby completing the driving work of the executing part 532.

[0044] Specifically speaking, the structure of the execution part 532 includes a fixed block 5321 fixedly arranged on the base 511, a first slide rail is vertically arranged on one side of the fixed block 5321, and a slider 5322 is vertically slidably arranged through the first slide rail, the connecting member is vertically slidably connected with the slider 5322, and can drive the slider 5322 to slide vertically; a second slide rail is horizontally arranged on one side of the slider 5322, and two clamping blocks 5323 that can slide laterally are relatively arranged through the second slide rail, the two clamping blocks 5323 are elastically connected to the slider 5322 and the directions of the elastic force are facing each other; a clamping plate 5324 is also vertically arranged on the two clamping blocks 5323, and the two clamping plates are connected to each other. The lower ends of 5324 are respectively connected to the two clamping blocks 5323, and the upper ends are bent toward each other. The upward movement of the slider 5322 can drive the two clamping blocks 5323 to move upward. The two clamping plates 5324 can pass over the cap and be clamped on both sides between the cap and the affinity column under the action of elasticity. When the slider 5322 moves downward, the clamping plates 5324 on both sides can bring the cap away from the affinity column to complete the uncapping work. The cap can be removed by only controlling the up and down movement of the slider 5322, which makes the uncapping work simpler and more convenient. The elastic setting of the two clamping blocks 5323 makes the uncapping system 5 suitable for the uncapping work of caps of multiple specifications, which significantly expands the applicability of the uncapping system 5.

[0045] Furthermore, one side of the second slide rail is disposed at the upper end of the slider 5322, which is two pillars extending outward, and the two clamping blocks 5323 are located inside the two pillars and are elastically connected to the inner sides of the pillars on both sides respectively.

[0046] In this embodiment, in order to enable the upper ends of the two clamping plates 5324 to be better clamped between the cap and the affinity column, thereby enabling the cap removal work to be better completed, a notch is further provided in the middle of the bent end of the clamping plate 5324.

[0047] In order to further ensure the clamping effect of the clamping plate 5324 , the notch is an arc-shaped structure facing the opposite clamping plate 5324 .

[0048] As a preferred embodiment, in order to prevent the splint 5324 from being affected by rust or other pollution during use and to ensure the service life of the splint 5324, the cap removal mechanism 53 also includes a protective cover 5325 buckled on the two clamping blocks 5323, and the protective cover 5325 is connected to the upper end of the slider 5322. It is buckled on the two splints 5324 and has an opening corresponding to the position of the notch on the upper end of the two splints 5324. When the slider 5322 moves upward, the lower end of the affinity column can pass through the opening and cooperate with the splint 5324, thereby completing the cap removal work through the splint 5324.

[0049] In order to protect the clamping plate 5324 from corrosion while ensuring the working strength of the clamping plate 5324 and thus ensuring its clamping effect, the clamping plate 5324 is made of stainless steel.

[0050] To further protect the splint 5324 from corrosion, a rust-resistant coating is applied thereon.

[0051] In this embodiment, combined with Figure 5 and Figure 6 In order to ensure the clamping effect of the clamping plate 5324 while allowing the two clamping plates 5324 to smoothly pass over the cap and complete the clamping work under the action of elasticity, the uncapping system 5 also includes a guide column 54 vertically arranged on the base 511 and located below the uncapping mechanism 53. The upper end diameter of the guide column 54 is smaller than the lower end diameter, and under the action of elasticity, the inner sides of the two clamping blocks 5323 slide and fit with the guide column 54.

[0052] In order to make the sliding of the clamping block 5323 along the guide column 54 smoother, the guide column 54 is configured to include an open section and a closed section at its upper end, the diameter of the open section is larger than the diameter of the closed section, and there is an arc-shaped transition between the open section and the closed section.

[0053] Combination Figure 6 In order to make the sliding work of the clamping block 5323 along the guide column 54 more stable, a notch is provided at the sliding fitting position between the clamping block 5323 and the guide column 54.

[0054] In order to ensure the strength of the guide column 54 while preventing the guide column 54 from being affected by corrosion, the guide column 54 is made of stainless steel.

Claims

1. A novel dual-wheel assembly line affinity column processing device, comprising a wheel-type transport system (2) and a wheel-type collection system (4), and also comprising a rinsing system (3) and a cap removal system (5), characterized in that: The cap removal system (5) comprises a stand (51) and a pressing mechanism (52) on its upper portion, and a cap removal mechanism (53) is also provided on one side of the stand (51); The cap-removing mechanism (53) comprises a slider (5322) capable of vertical sliding, and two clamping blocks (5323) capable of horizontal sliding are arranged on one side of the slider (5322) in a horizontal manner, and the two clamping blocks (5323) are elastically connected to the slider (5322) and are subjected to elastic forces in directions facing each other. A clamping plate (5324) is also vertically provided on the two clamping blocks (5323), the lower ends of the two clamping plates (5324) are respectively connected to the two clamping blocks (5323), and the upper ends are bent toward each other.

2. A novel dual-wheel assembly line affinity column processing device according to claim 1, characterized in that: A notch is provided in the middle of the bent end of the clamping plate (5324).

3. A novel dual-wheel assembly line affinity column processing device according to claim 2, characterized in that: The notch is an arc-shaped structure facing the opposite side splint (5324).

4. A novel dual-wheel assembly line affinity column processing device according to claim 1, characterized in that: The cap removal system (5) further comprises a guide column (54) vertically arranged below the cap removal mechanism (53); The diameter of the upper end of the guide column (54) is smaller than the diameter of the lower end, and the two clamping blocks (5323) are both slidably fitted with the guide column (54).

5. A novel dual-wheel assembly line affinity column processing device according to claim 4, characterized in that: The guide column (54) comprises an open section and a closed section at its upper end, the open section has a diameter greater than a diameter of the closed section, and an arc-shaped transition is formed between the open section and the closed section.

6. A novel dual-wheel assembly line affinity column processing device according to claim 4, characterized in that: A notch is provided at the position where the clamping block (5323) and the guide column (54) slide and fit together.

7. A novel dual-wheel assembly line affinity column processing device according to claim 4, characterized in that: The guide column (54) is made of stainless steel.

8. A novel dual-wheel assembly line affinity column processing device according to claim 2, characterized in that: The cap-removing mechanism (53) further comprises a protective cover (5325) buckled on the two clamping blocks (5323), and the protective cover (5325) is provided with an opening at a position corresponding to the notch on the upper ends of the two clamping plates (5324).

9. A novel dual-wheel assembly line affinity column processing device according to any one of claims 1 to 8, characterized in that: The clamping plate (5324) is made of stainless steel.

10. A novel dual-wheel assembly line affinity column processing device according to claim 9, characterized in that: The clamping plate (5324) is coated with a rust-resistant coating.

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