Ceramic membrane filtration system for preparing ergothioneine

Abstract

The utility model discloses a ceramic membrane filtration system for preparing ergothioneine, which comprises a fermentation tank, a circulating pump, a filter, a first ceramic membrane filtration assembly and a second ceramic membrane filtration assembly, the outlet of the fermentation tank is connected with the input end of the circulating pump, the output end of the circulating pump is connected with the filter, and the first ceramic membrane filtration assembly is connected with the second ceramic membrane filtration assembly. The filter is connected with an inlet of the first ceramic membrane filtration assembly, the first ceramic membrane filtration assembly and the second ceramic membrane filtration assembly are respectively provided with a dialysate outlet and a concentrated solution outlet, and an inlet of the second ceramic membrane filtration assembly is connected with the concentrated solution outlet of the first ceramic membrane filtration assembly. And a dialysate outlet of the second ceramic membrane filtering assembly is connected with an inlet of the first ceramic membrane filtering assembly. According to the ergothioneine extraction device, ergothioneine in fermentation liquor can be fully obtained, and the yield of ergothioneine is improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of filtering equipment and relates to a ceramic membrane filtering system for preparing ergothioneine. Background Art

[0002] At present, the main process of preparing thioneine by biological fermentation is as follows: fermentation-filtration (ceramic membrane filtration)-filtration (ultrafiltration membrane filtration)-purification column (from intersection)-concentration-crystallization-concentration-crystallization-drying-dissolving-from intersection-filtration (nanofiltration)-concentration-drying-recrystallization. In the ceramic membrane filtration process, after the fermentation liquid is inactivated, filtered through a 50nm ceramic membrane, constant pressure filtration, pressure control 0.5mpa or so, control temperature <40 ℃, ceramic membrane adds deionized water top wash, product is transparent, ensure yield>98%, stop filtering, the clear liquid of ceramic membrane enters the next process.

[0003] However, after the fermentation liquid of ergothioneine in the circulation tank is filtered through a ceramic membrane, the blocked concentrated liquid still contains part of ergothioneine, and the existing ceramic membrane filtration system is not fully utilized. Utility Model Content

[0004] The utility model aims to provide a ceramic membrane filtration system for preparing thioneine, which can fully obtain thioneine in a fermentation broth and improve the yield of thioneine.

[0005] The technical solution adopted in the utility model is as follows: a ceramic membrane filtration system for preparing ergothioneine, comprising a fermentation tank, a circulation pump, a filter, a first ceramic membrane filter assembly and a second ceramic membrane filter assembly, the outlet of the fermentation tank is connected to the input end of the circulation pump, the output end of the circulation pump is connected to the filter, the filter is connected to the inlet of the first ceramic membrane filter assembly, the first ceramic membrane filter assembly and the second ceramic membrane filter assembly both have a dialysate outlet and a concentrated solution outlet, the inlet of the second ceramic membrane filter assembly is connected to the concentrated solution outlet of the first ceramic membrane filter assembly, and the dialysate outlet of the second ceramic membrane filter assembly is connected to the inlet of the first ceramic membrane filter assembly.

[0006] Furthermore, a feed pump is provided between the inlet of the second ceramic membrane filter assembly and the concentrated liquid outlet of the first ceramic membrane filter assembly.

[0007] Furthermore, a temporary storage tank is provided between the feed pump and the inlet of the second ceramic membrane filtration assembly.

[0008] Furthermore, the filtration rate of the second ceramic membrane filtration component is lower than that of the first ceramic membrane filtration component.

[0009] Furthermore, the filter includes a security filter.

[0010] Furthermore, a regulating valve is provided between the dialysate outlet of the second ceramic membrane filter assembly and the inlet of the first ceramic membrane filter assembly.

[0011] Compared with the prior art, the beneficial effects of the utility model are:

[0012] The ceramic membrane filtration system of the utility model comprises a fermentation tank, a circulation pump, a filter, a first ceramic membrane filtration assembly and a second ceramic membrane filtration assembly. After fermentation is completed in the fermentation tank by a biological fermentation mode to generate thioneine, the fermentation liquid is transported under the action of the circulation pump. The filter forms a coarse filtration on the fermentation liquid. In the first ceramic membrane filtration assembly, 50nm ceramic membrane filtration is performed, constant pressure filtration is performed, and the pressure is controlled to be about 0.5mpa. The temperature is controlled to be less than 40°C. The fermentation liquid is subjected to ceramic membrane filtration, and the dialysate enters the subsequent ultrafiltration membrane filtration. The blocked concentrated solution is then returned to the second ceramic membrane filtration assembly for rapid and preliminary ceramic membrane filtration. The dialysate produced at this time is then refluxed to the inlet of the first ceramic membrane filtration assembly again, and enters the subsequent ultrafiltration membrane filtration again through the secondary filtration of the first ceramic membrane filtration assembly. The utility model can fully obtain the thioneine in the fermentation liquid, and improve the yield of the thioneine. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the following is a brief introduction to the drawings required for use in the embodiments. It should be understood that the following drawings only show certain embodiments of the present utility model and should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without creative work, including:

[0014] Figure 1 The utility model is a structural schematic diagram of a ceramic membrane filtration system for preparing ergothioneine.

[0015] Markings in the figure:

[0016] 10- Fermentation tank;

[0017] 20-circulation pump;

[0018] 30-Filter;

[0019] 40-first ceramic membrane filtration component;

[0020] 50-second ceramic membrane filtration assembly;

[0021] 60-feeding pump;

[0022] 70-temporary storage tank;

[0023] 80-Regulating valve. DETAILED DESCRIPTION

[0024] In order to make the purpose, technical solution and advantages of the utility model more clear, the utility model is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the utility model and are not used to limit the utility model, that is, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. The components of the embodiments of the utility model described and shown in the drawings here can be arranged and designed in various different configurations.

[0025] Therefore, the following detailed description of the embodiments of the utility model provided in the accompanying drawings is not intended to limit the scope of the utility model claimed for protection, but merely represents selected embodiments of the utility model. Based on the embodiments of the utility model, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the utility model.

[0026] It should be noted that relational terms such as "first" and "second" are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "comprise a ..." do not exclude the existence of other identical elements in the process, method, article or device including the elements.

[0027] As described in background technology, at present, the main process flow of preparing thioneine by biological fermentation is as follows: fermentation-filtration (ceramic membrane filtration)-filtration (ultrafiltration membrane filtration)-purification column (from intersection)-concentration-crystallization-concentration-crystallization-drying-dissolving-from intersection-filtration (nanofiltration)-concentration-drying-recrystallization. In ceramic membrane filtration process, after fermentation liquid is inactivated, through 50nm ceramic membrane filtration, constant pressure filtration, pressure control 0.5mpa or so, control temperature <40 DEG C, ceramic membrane adds deionized water top wash, makes product see through, ensures yield>98%, stops filtering, and the clear liquid of ceramic membrane enters the next process.

[0028] However, after the fermentation liquid of ergothioneine in the circulation tank is filtered through a ceramic membrane, the blocked concentrated liquid still contains part of ergothioneine, and the existing ceramic membrane filtration system is not fully utilized.

[0029] Based on this, the inventor has created a ceramic membrane filtration system for preparing ergothioneine of the present application to solve the above-mentioned technical problems.

[0030] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0031] Example

[0032] See also Figure 1 , a ceramic membrane filtration system for preparing thioneine, including a fermentation tank 10, a circulating pump 20, a filter 30, a first ceramic membrane filter assembly 40 and a second ceramic membrane filter assembly 50. Here, the fermentation tank 10 is a tank body for obtaining thioneine by biological fermentation, and the outlet of the fermentation tank 10 can be arranged at its bottom. In addition, a fire extinguishing device can also be arranged between the fermentation tank 10 and the circulating pump 20 to inactivate the fermented liquid. The outlet of the fermentation tank 10 is connected to the input end of the circulating pump 20, and the output end of the circulating pump 20 is connected to the filter 30, and the filter 30 is connected to the inlet of the first ceramic membrane filter assembly 40. For example, the filter 30 can be a security filter 30, with high filtering accuracy, uniform filter element pore size, small filtering resistance, large flux, strong pollution interception ability, long service life, high cleanliness of the filter element material, and no pollution to the filter medium.

[0033] The first ceramic membrane filter assembly 40 and the second ceramic membrane filter assembly 50 both have a dialysate outlet and a concentrated solution outlet, and the inlet of the second ceramic membrane filter assembly 50 is connected to the concentrated solution outlet of the first ceramic membrane filter assembly 40, and the dialysate outlet of the second ceramic membrane filter assembly 50 is connected to the inlet of the first ceramic membrane filter assembly 40. Here, the dialysate outlet refers to the dialysate formed by the ergothioneine component that can pass through the ceramic membrane after the fermented liquid is filtered through the ceramic membrane, and the concentrated solution is the liquid blocked by the ceramic membrane. The concentrated solution enters the second ceramic membrane filter assembly 50 and carries out ceramic membrane filtration, so that the residual ergothioneine incidental therein is recovered through the first ceramic membrane filter assembly 40.

[0034] The ceramic membrane filtration system of the utility model comprises a fermentation tank 10, a circulating pump 20, a filter 30, a first ceramic membrane filter assembly 40 and a second ceramic membrane filter assembly 50. After fermentation is completed in the fermentation tank 10 by means of biological fermentation to generate thioneine, the fermentation liquid is conveyed under the action of the circulating pump 20. The filter 30 forms a coarse filtration to the fermentation liquid. In the first ceramic membrane filter assembly 40, 50nm ceramic membrane filtration is performed, constant pressure filtration is performed, and the pressure is controlled to be about 0.5mpa. The temperature is controlled to be less than 40°C. The fermentation liquid is subjected to ceramic membrane filtration, and the dialysate enters subsequent ultrafiltration membrane filtration. The blocked concentrated solution is then returned to the second ceramic membrane filter assembly 50 for rapid and preliminary ceramic membrane filtration. The dialysate produced at this time is then refluxed to the inlet of the first ceramic membrane filter assembly 40 again, and enters subsequent ultrafiltration membrane filtration again through the secondary filtration of the first ceramic membrane filter assembly 40. The utility model can fully obtain the thioneine in the fermentation liquid, and improve the yield of thioneine.

[0035] In another embodiment, a feed pump 60 is provided between the inlet of the second ceramic membrane filter assembly 50 and the concentrated liquid outlet of the first ceramic membrane filter assembly 40. In this way, the concentrated liquid is easily transported from the first ceramic membrane filter assembly 40 to the second ceramic membrane filter assembly 50.

[0036] In another embodiment, a temporary storage tank 70 is further provided between the feed pump 60 and the inlet of the second ceramic membrane filtration assembly 50. With such a configuration, the concentrated liquid can be collected by the temporary storage tank, and the second ceramic membrane filtration assembly 50 can perform ceramic membrane filtration in an orderly manner.

[0037] In another embodiment, the filtration speed of the second ceramic membrane filter assembly 50 is lower than that of the first ceramic membrane filter assembly 40. In this way, the second ceramic membrane filter assembly 50 performs rapid preliminary filtration on the concentrated solution containing a small amount of ergothioneine, thereby improving efficiency.

[0038] In another embodiment, a regulating valve 80 is provided between the dialysate outlet of the second ceramic membrane filter assembly 50 and the inlet of the first ceramic membrane filter assembly 40. In this way, the regulating valve 80 can effectively control the flow rate entering the first ceramic membrane filter assembly 40, and adjust the proportion of the fermentation liquid from the fermentation tank 10.

[0039] The above description is only a preferred embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions and improvements made by any technician familiar with the field within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A ceramic membrane filtration system for preparing thioneine, characterized in that, It includes a fermentation tank, a circulation pump, a filter, a first ceramic membrane filter assembly and a second ceramic membrane filter assembly, the outlet of the fermentation tank is connected to the input end of the circulation pump, the output end of the circulation pump is connected to the filter, the filter is connected to the inlet of the first ceramic membrane filter assembly, the first ceramic membrane filter assembly and the second ceramic membrane filter assembly both have a dialysate outlet and a concentrated liquid outlet, the inlet of the second ceramic membrane filter assembly is connected to the concentrated liquid outlet of the first ceramic membrane filter assembly, and the dialysate outlet of the second ceramic membrane filter assembly is connected to the inlet of the first ceramic membrane filter assembly.

2. a kind of ceramic membrane filtration system preparing thioneine according to claim 1, is characterized in that, A feed pump is provided between the inlet of the second ceramic membrane filter assembly and the concentrated liquid outlet of the first ceramic membrane filter assembly.

3. a kind of ceramic membrane filtration system preparing thioneine according to claim 2, is characterized in that, A temporary storage tank is also arranged between the feed pump and the inlet of the second ceramic membrane filtration assembly.

4. a kind of ceramic membrane filtration system preparing thioneine according to claim 1, is characterized in that, The filtration rate of the second ceramic membrane filtration component is lower than that of the first ceramic membrane filtration component.

5. a kind of ceramic membrane filtration system preparing thioneine according to claim 1, is characterized in that, The filter comprises a security filter.

6. according to a kind of ceramic membrane filtration system preparing thioneine according to any one of claims 1-5, it is characterised in that, A regulating valve is provided between the dialysate outlet of the second ceramic membrane filter assembly and the inlet of the first ceramic membrane filter assembly.

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