Cover body assembly for reagent tube and reagent tube device

Abstract

The utility model discloses a reagent tube cover body assembly and reagent tube device, the reagent tube cover body assembly comprises a first cover body and a second cover body, the lower end of the first cover body forms a plugging part, the plugging part is used for being plugged into the tube mouth of the reagent tube, the upper end of the first cover body concaves downwards to form a covering space, and the covering space is used for covering the reagent tube. A covering space is formed in the first cover body, a notch channel penetrating through the first cover body is formed in the bottom wall of the covering space, the second cover body is detachably plugged into the covering space, before sample adding operation, the second cover body is taken out from the covering space, at the moment, the notch channel is in a closed state, and an inner cavity of the reagent tube is still isolated from the outside; the sample adding pipe is extruded downwards to open the notch channel to extend into the reagent pipe, after sample adding is finished, the sample adding pipe is taken out, the notch channel is elastically reset to seal the reagent pipe again, and therefore it can be guaranteed that the reagent pipe is in a sealed state under most conditions through the cover body assembly, gas exchange between the reagent pipe and outside air is prevented, aerosol is prevented from being generated, and the sample adding effect is good. And the anti-pollution effect is achieved.

Description

Technical Field

[0001] The utility model belongs to the technical field of in vitro detection, and in particular relates to a cover assembly for a reagent tube and a reagent tube device. Background Art

[0002] PCR is a molecular biology technique used to amplify specific DNA fragments. It can be seen as a special DNA replication outside the body. Nucleic acids can be denatured and unwound into single strands under the action of multiple enzymes. With the participation of polymerase, they are replicated into two identical molecular copies according to the principle of base complementary pairing. During the experiment, samples and detection reagents should be isolated from the outside world as much as possible to avoid aerosol contamination.

[0003] In the prior art, soft and hard rubber after two-color injection molding is used as the tube cover for sealing with the tube body. The solution will have good sealing in the amplification area of ​​the standard PCR laboratory, but in the subsequent steps, it is necessary to add reagents to the reagent tube, and the tube cover and the tube body need to be separated. After the reagents are added, the tube cover and the tube body are buckled and sealed. There is a great risk of contamination in this process. Utility Model Content

[0004] In view of the above-mentioned defects or shortcomings, the utility model provides a reagent tube cover assembly and a reagent tube device, aiming to solve the technical problem in the prior art that the reagent tube cover assembly has a high risk of being contaminated by aerosols during the reagent adding stage.

[0005] To achieve the above-mentioned purpose, the utility model provides a cover assembly for reagent tubes, wherein the cover assembly for reagent tubes includes a first cover and a second cover, the lower end of the first cover forms a plugging portion, the plugging portion is used to be plugged into the tube mouth of the reagent tube, the upper end of the first cover is recessed to form a cover space, and a cutout channel that passes through the first cover is opened on the bottom wall of the cover space, the cutout channel is opened under the pressure of the sample tube to allow the sample tube to enter the reagent tube, and the second cover can be detachably plugged into the cover space.

[0006] In an embodiment of the utility model, the cutout channel includes an opening section and a cutout section arranged in sequence from top to bottom, the aperture of the opening section is smaller than the aperture of the cover space, and the cutout section has at least two intersecting cutouts.

[0007] In the embodiment of the utility model, the cutout shape of the cutout channel is set to be a cross shape.

[0008] In an embodiment of the utility model, the first cover body includes a first cover body and a first cover plate portion, the first cover body forms a plugging portion, a cover-mounting space and a cut-out channel, the first cover plate portion extends from the upper end periphery of the first cover body, the second cover body includes a second cover body, a second cover plate portion and a first connecting strip connecting the first cover plate portion and the second cover plate portion, the second cover body is arranged on the second cover plate portion and can be detachably plugged into the cover-mounting space.

[0009] In an embodiment of the utility model, the first cover body is configured to be made of rubber material, and / or the second cover body is configured to be made of rubber material.

[0010] In an embodiment of the utility model, the number of first cover bodies is at least two, and at least two first cover bodies are arranged in sequence and spaced apart along the length direction of the first cover plate portion; the number of second cover bodies is at least two, and at least two second cover bodies are arranged in sequence and spaced apart along the length direction of the second cover plate portion; and at least two second cover bodies can be detachably inserted into the cover installation space of at least two first cover bodies one by one.

[0011] In an embodiment of the utility model, the first cover plate portion is made of soft material, and a spacing adjustment hole is provided between two adjacent first cover bodies of the first cover plate portion.

[0012] In an embodiment of the utility model, the inner wall of the spacing adjustment hole arranged near the first cover body is raised, and / or the first cover plate portion is provided with an extension portion extending from the circumferential side of the two adjacent first cover bodies, the extension portion is made of soft material, and the end of the spacing adjustment hole extends from the first cover plate portion to the extension portion.

[0013] In an embodiment of the utility model, the outer edge of the plugging portion is laterally extended from the lower end of the first cover body to be used for sealingly abutting against the inner wall of the reagent tube.

[0014] In order to achieve the above-mentioned objectives, the utility model further provides a reagent tube device, wherein the reagent tube device comprises a reagent tube and the above-mentioned reagent tube cover assembly.

[0015] Through the above technical solution, the reagent tube cover assembly provided by the embodiment of the utility model has the following beneficial effects:

[0016] When the above-mentioned reagent tube cover assembly is used, the lower end of the first cover forms a plugging portion, which is inserted into the tube mouth of the reagent tube and sealed against the inner wall of the reagent tube. The upper end of the first cover is recessed to form a cover space. When there is no need to add samples to the reagent tube during transfer, amplification, etc., the second cover can be inserted into the cover space to achieve sealing of the reagent tube. Before performing the sample addition operation, the second cover is taken out from the cover space. At this time, the incision channel is in a closed state, and the inner cavity of the reagent tube is still isolated from the outside world. When adding samples, the sample addition tube is squeezed downward to open the incision channel and extend into the reagent tube. After the sample addition is completed, the sample addition tube is taken out, and the incision channel is elastically reset to re-seal the reagent tube. Through the cover assembly, it can be ensured that the reagent tube is in a sealed state in most cases, preventing gas exchange with the outside air, avoiding the generation of aerosols, and achieving an anti-pollution effect.

[0017] Other features and advantages of the present invention will be described in detail in the subsequent specific implementation section. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The accompanying drawings are used to provide an understanding of the present invention and constitute a part of the specification. Together with the following specific embodiments, they are used to explain the present invention, but do not constitute a limitation to the present invention. In the accompanying drawings:

[0019] Figure 1 It is a partial structural schematic diagram of a reagent tube cover assembly according to an embodiment of the utility model;

[0020] Figure 2 It is a structural schematic diagram of a reagent tube device according to an embodiment of the utility model;

[0021] Figure 3 is a cross-sectional view of a reagent tube device according to an embodiment of the utility model;

[0022] Figure 4 It is a partial cross-sectional view of a reagent tube according to an embodiment of the utility model.

[0023] Description of Reference Numerals

[0024] 1 First cover 11 Plug-in portion

[0025] 12 Cover space 13 Cutout channel

[0026] 131 Opening section 132 Cut section

[0027] 14 Main body 15 First cover body

[0028] 16 first cover plate portion 161 extension portion

[0029] 162 spacing adjustment hole 2 second cover

[0030] 21 second cover body 22 second cover plate portion

[0031] 23 First connection strip 3 Reagent tube

[0032] 31 Cover installation opening 32 Sealing groove

[0033] 33 first stopper 34 second stopper DETAILED DESCRIPTION

[0034] The specific embodiments of the present invention are described in detail below in conjunction with the accompanying drawings. It should be understood that the specific embodiments described herein are only used to illustrate and explain the present invention, and are not used to limit the present invention.

[0035] The reagent tube cover assembly and the reagent tube device of the present invention are described below with reference to the accompanying drawings.

[0036] like Figure 1 As shown, the utility model provides a cover assembly for a reagent tube, wherein the cover assembly for a reagent tube comprises:

[0037] A first cover body 1, a plugging portion 11 is formed at the lower end of the first cover body 1, and the plugging portion 11 is used to be plugged into the tube mouth of the reagent tube 3. The upper end of the first cover body 1 is concave to form a cover installation space 12, and a cutout channel 13 penetrating the first cover body 1 is opened on the bottom wall of the cover installation space 12. The cutout channel 13 is opened under the pressure of the sample tube to allow the sample tube to enter the reagent tube 3;

[0038] The second cover body 2 can be inserted into the cover installation space 12 in a detachable manner.

[0039] When the above-mentioned reagent tube cover assembly is used, the lower end of the first cover body 1 forms a plugging portion 11, which is plugged into the tube mouth of the reagent tube 3 and sealed with the inner wall of the reagent tube 3. The upper end of the first cover body 1 is concave to form a cover space 12. When there is no need to add samples to the reagent tube 3 during transfer, amplification, etc., the second cover body 2 can be plugged into the cover space 12 to achieve sealing of the reagent tube 3. Before the sample addition operation, the second cover body 2 is taken out from the cover space 12. At this time, the incision channel 13 is in a closed state, and the inner cavity of the reagent tube 3 is still isolated from the outside. When adding samples, the sample addition tube is squeezed downward to open the incision channel 13 and extend into the reagent tube 3. After the sample addition is completed, the sample addition tube is taken out, and the incision channel 13 is elastically reset to re-seal the reagent tube 3. Through the cover assembly, it can be ensured that the reagent tube 3 is in a sealed state in most cases, preventing its gas exchange with the outside air, avoiding the generation of aerosols, and achieving an anti-pollution effect.

[0040] In the embodiment of the utility model, the cutout channel 13 includes an opening section 131 and a cutout section 132 arranged in sequence from top to bottom. The aperture of the opening section 131 is smaller than the aperture of the cover space 12, and the cutout section 132 has at least two intersecting cutouts. By designing the opening section 131, when the second cover 2 is inserted into the cover space 12, the second cover 2 abuts against the bottom wall of the cover space 12 and does not contact the cutout section 132, thereby avoiding the problem of the second cover 2 squeezing and opening the cutout section 132. Specifically, the cutout shape of the cutout channel 13 is preferably a cross shape. Of course, the cutout shape can also be designed as a centrally symmetrical cross shape, a Y shape, or other shapes.

[0041] In an embodiment of the utility model, the first cover body 1 includes a first cover body 15 and a first cover plate portion 16, the first cover body 15 forms a plugging portion 11, a cover-mounting space 12 and a cutout channel 13, the first cover plate portion 16 extends from the upper end periphery of the first cover body 15, the second cover body 2 includes a second cover body 21, a second cover plate portion 22 and a first connecting strip 23 connecting the first cover plate portion 16 and the second cover plate portion 22, the second cover body 21 is arranged on the second cover plate portion 22 and can be detachably plugged into the cover-mounting space 12. The first cover portion 16 and the second cover portion 22 play a role of abutment and positioning. The first cover portion 16 abuts against the upper end surface of the reagent tube 3, and the second cover is used to abut against the first cover portion 16 when the second cover body 21 is inserted into the cover space 12. In addition, when it is necessary to take out the second cover body 21 from the cover space 12, the second cover portion 22 can be uncovered to take the second cover body 21 out of the cover space 12; the setting of the first connecting strip 23 connects the first cover body 1 and the second cover body 2 into a whole. During the entire in vitro detection process, there is no need to place the second cover body 2 separately. After the sample addition operation is completed, the second cover body 2 can be quickly covered to improve the sealing effect on the reagent tube 3.

[0042] Specifically, the first cover body 15 includes a plugging portion 11 and a main body 14 which are arranged in sequence from bottom to top. The plugging portion 11 is set to be soft rubber (such as TPU), and a cross-shaped cutout section 132 is opened at the center. The two sides of the cutout form a slice structure correspondingly. The slice structure has a certain elasticity. When subjected to pressure, the slice structure bends and deforms, so that the cutout section 132 is opened, and the sample tube can be inserted into the reagent tube 3. After the pressure is removed, the slice structure is reset, and the adjacent slice structures are spliced ​​together, and the cutout section 132 is closed to achieve the sealing of the reagent tube 3. Further, the main body 14 adopts hard rubber to support the second cover body 21, and the second cover body 21 adopts soft rubber to achieve the extrusion and splicing of the second cover body 21 and the main body 14 to achieve the sealing of the cutout channel 13.

[0043] More specifically, a countersunk hole is formed at one end of the second cover body 21 away from the first cover body 15 , and both sides of the second cover plate extend out of the second cover body 21 .

[0044] like Figure 2 As shown, in the embodiment of the utility model, the number of the first cover bodies 15 is at least two, and the at least two first cover bodies 15 are sequentially spaced along the length direction of the first cover plate portion 16, the number of the second cover bodies 21 is at least two, and the at least two second cover bodies 21 are sequentially spaced along the length direction of the second cover plate portion 22, and the at least two second cover bodies 21 are detachably inserted into the cover installation space 12 of the at least two first cover bodies 15 in a one-to-one correspondence. Through this multi-row arrangement, batch operations can be realized during in vitro detection, such as synchronous opening of the second cover body 2, synchronous transfer, synchronous amplification, etc., to improve detection efficiency.

[0045] Specifically, both ends of the first cover portion 16 are also formed with clamping portions for cooperating with the clamping ports on the detection bracket for fixation, thereby ensuring the stability of the reagent tube 3 on the detection bracket during the detection process.

[0046] Furthermore, the number of the first connecting strips 23 is at least two, and they are arranged in a one-to-one correspondence with the first cover body 15 and the second cover body 21 .

[0047] like Figure 2 As shown, in an embodiment of the utility model, the first cover plate portion 16 is set to be a soft material, and the first cover plate portion 16 is provided with a spacing adjustment hole 162 between two adjacent first cover bodies 15. It is used to appropriately adjust the spacing between adjacent first cover bodies 15 according to the actual spacing between adjacent reagent tubes 3. Specifically, the inner wall of the spacing adjustment hole 162 close to the first cover body 15 is convex, and the first cover plate portion 16 is provided with two extension portions 161 extending from the circumference of the two adjacent first cover bodies 15. The extension portion 161 is a soft material, and the end of the spacing adjustment hole 162 extends from the first cover plate portion 16 to the extension portion 161, and the two extension portions 161 are bent back to back to facilitate the adjustment of the spacing between adjacent first cover bodies 15.

[0048] like Figure 1 , Figure 3 and Figure 4As shown, in the embodiment of the utility model, the outer diameter of the plugging part 11 is larger than the outer diameter of the main body 14, so as to form a protruding sealing surface, a sealing groove 32 is formed on the inner wall of the reagent tube 3, the outer edge of the plugging part 11 is embedded in the sealing groove 32, and the sealing surface of the plugging part 11 is sealed and spliced ​​with the groove wall of the sealing groove 32 to achieve the seal between the reagent tube 3 and the reagent tube cover assembly. Specifically, the plugging part 11 is preferably made of soft rubber, and the reagent tube 3 is set to a hard material (which can be glass, plastic, etc.), and the sealing surface of the plugging part 11 is fully in contact with the groove wall of the sealing groove 32 by extrusion deformation to ensure the reliability of the seal.

[0049] Furthermore, a gradually expanding cover installation opening 31 is formed above the sealing groove 32 of the reagent tube 3. This gradually expanding design can reduce the contact between the first cover 1 and the reagent tube 3 during the installation process, thereby improving the installation efficiency.

[0050] In addition, in another embodiment of the utility model, the plugging portion 11 can also be designed to be in the shape of a sleeve, and the material is also preferably soft rubber. The side wall of the main body 14 is wrapped as a whole by the plug-shaped portion, and the elasticity of the soft rubber is utilized to directly seal and press against the inner wall of the reagent tube 3; in another embodiment of the utility model, the plugging portion 11 and the reagent tube 3 can also be connected by a thread, and the outer edge of the plugging portion 11 is set to a hard material and formed with an external thread section, and the inner wall of the reagent tube 3 is correspondingly formed with an internal thread.

[0051] In order to achieve the above objectives, the utility model also provides a reagent tube device, wherein the reagent tube device comprises a reagent tube 3 and the above reagent tube cover assembly, see Figure 4 The outer wall of the reagent tube 3 is convex with a first stopper 33 and a second stopper 34, which are arranged from bottom to top. The second stopper 34 is located at the top of the reagent tube 3 and abuts against the first cover plate 16. The upper end surface of the first stopper 33 is a plane, and the lower end surface is an arc surface. Figure 2 As shown, the reagent tube device includes four reagent tubes 3 that are spaced apart in sequence, and adjacent reagent tubes 3 are connected by a second connecting strip, and the connecting end of the second connecting strip is located between the first stop portion 33 and the second stop portion 34. The reagent tubes 3 are covered with a reagent tube cover assembly, and the cover assembly includes four first cover bodies 15 and four second cover bodies 21, so as to cover the four reagent tubes 3 in a one-to-one correspondence. In some other embodiments of the utility model, the number of reagent tubes 3 can also be set to other numbers, and the number of first cover bodies 15 and second cover bodies 21 on the cover assembly is also set corresponding to the number of reagent tubes 3. Since the reagent tube device adopts all the technical solutions of the above embodiments, it has the above-mentioned beneficial effects, which will not be repeated here one by one.

[0052] In the description of the present invention, it should be understood that the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of the features. In the description of the present invention, "plurality" means at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0053] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral one; it can be a mechanical connection, an electrical connection, or communication with each other; it can be a direct connection, or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0054] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine the different embodiments or examples described in this specification and the features of the different embodiments or examples, without contradiction.

[0055] Although the embodiments of the present invention have been shown and described above, it can be understood that the above embodiments are exemplary and cannot be understood as limitations of the present invention. Ordinary technicians in the field can change, modify, replace and modify the above embodiments within the scope of the present invention.

Claims

1. A cover assembly for a reagent tube, characterized in that: The reagent tube cover assembly comprises: A first cover body (1), wherein a plugging portion (11) is formed at the lower end of the first cover body (1), and the plugging portion (11) is used to be plugged into the tube mouth of the reagent tube (3); the upper end of the first cover body (1) is concave to form a cover-mounting space (12), and a cutout channel (13) penetrating the first cover body (1) is formed on the bottom wall of the cover-mounting space (12); the cutout channel (13) is opened under the pressure of the sample tube to allow the sample tube to enter the reagent tube (3); The second cover body (2) can be removably inserted into the cover installation space (12).

2. The reagent tube cover assembly according to claim 1, characterized in that: The cutout channel (13) comprises an opening section (131) and a cutout section (132) arranged in sequence from top to bottom, the aperture of the opening section (131) is smaller than the aperture of the cover-mounted space (12), and the cutout section (132) has at least two cutouts arranged to intersect.

3. The reagent tube cover assembly according to claim 2, characterized in that: The cutout shape of the cutout channel (13) is set to be a cross shape.

4. The reagent tube cover assembly according to claim 1, characterized in that: The first cover body (1) includes a first cover body (15) and a first cover plate portion (16), the first cover body (15) forming the plugging portion (11), the cover-mounting space (12) and the cutout channel (13), the first cover plate portion (16) extending from the upper end periphery of the first cover body (15), the second cover body (2) includes a second cover body (21), a second cover plate portion (22) and a first connecting strip (23) connecting the first cover plate portion (16) and the second cover plate portion (22), the second cover body (21) being arranged on the second cover plate portion (22) and being detachably plugged into the cover-mounting space (12).

5. The reagent tube cover assembly according to claim 4, characterized in that: The first cover body (15) is made of rubber material, and / or the second cover body (21) is made of rubber material.

6. The reagent tube cover assembly according to claim 4, characterized in that: The number of the first cover bodies (15) is at least two, and at least two of the first cover bodies (15) are arranged in sequence and spaced apart along the length direction of the first cover plate portion (16); the number of the second cover bodies (21) is at least two, and at least two of the second cover bodies (21) are arranged in sequence and spaced apart along the length direction of the second cover plate portion (22); and at least two of the second cover bodies (21) are detachably inserted into the cover installation space (12) of at least two of the first cover bodies (15) in a one-to-one correspondence.

7. The reagent tube cover assembly according to claim 4, characterized in that: The first cover plate portion (16) is made of a soft material, and the first cover plate portion (16) is provided with a spacing adjustment hole (162) between two adjacent first cover bodies (15).

8. The reagent tube cover assembly according to claim 7, characterized in that: The inner wall of the spacing adjustment hole (162) disposed near the first cover body (15) is raised, and / or the first cover plate portion (16) is provided with an extension portion (161) extending from the circumferential side of two adjacent first cover bodies (15), the extension portion (161) is made of soft material, and the end of the spacing adjustment hole (162) extends from the first cover plate portion (16) to the extension portion (161).

9. The reagent tube cover assembly according to any one of claims 1 to 8, characterized in that: The outer edge of the plugging portion (11) is laterally extended from the lower end of the first cover body (1) so as to be in sealing contact with the inner wall of the reagent tube (3).

10. A reagent tube device, characterized in that: The reagent tube device comprises a reagent tube (3) and a reagent tube cover assembly according to any one of claims 1 to 9.

Images