Batch charging reaction equipment
By providing a batch feeding reaction device, and automatically adding reaction materials using the first batch feeding device and the second batch feeding device, the problems of low efficiency and inaccurate control of manual batch feeding reactions in the prior art are solved, and efficient and accurate control of reaction materials and reaction conditions are achieved.
Patent Information
- Application Number
- CN202421064420.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-05-15
- Publication Date
- 2025-03-21
- Estimated Expiration
- 2034-05-15
AI Technical Summary
In the prior art, in the preparation scenario where reaction materials need to be added in batches, the batch addition reactions that rely on manual implementation are inefficient and are susceptible to human factors, resulting in insufficient control of reaction conditions, which increases the work risks of staff.
A batch feeding reaction device is provided, including a reactor, a first feeding device and a second feeding device, through which the first and second material are put into the reactor in batches and at predetermined time intervals, thereby realizing the process of adding reaction materials automatically.
The process of automatically adding reaction materials in batches is realized, which improves feeding efficiency, reduces the influence of human factors, improves the control accuracy of reaction conditions, and reduces the work risks of staff.
Smart Images
Figure CN222642007U_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the technical field of pharmaceutical and chemical preparation equipment, and in particular to a batch-feeding reaction equipment. Background Art
[0002] In the field of pharmaceutical chemicals, in the preparation of some substances, in order to avoid excessive heat release, avoid overreaction, adjust the reaction rate, avoid side reactions, etc., it is generally necessary to add the reaction materials into the reaction solvent in batches. For example, it may be necessary to add two different solid materials into the solvent for reaction in batches; for another example, it may be necessary to add two different liquid materials into the solvent for reaction in batches; for another example, it is also possible to add solid materials and liquid materials into the solvent for reaction in batches.
[0003] In the prior art, in the preparation scenario where the reaction materials need to be added in batches, the preparation personnel are generally required to weigh the reaction materials in advance according to the ratio of each reaction material, and divide them into multiple small portions, and then sequentially add the small portions of the reaction materials into the reaction solvent according to each reaction interval. This batch addition reaction that relies on manual implementation is not only inefficient, but also easily affected by human factors, resulting in inaccurate control of the reaction conditions. At the same time, it also increases the work risk of the staff. Utility Model Content
[0004] The purpose of the embodiments of the present application is to provide a batch feeding reaction device, which can realize the process of quantitatively adding materials to the reactor in batches.
[0005] The present application provides a batch feeding reaction equipment, including a reactor, a first feeding device and a second feeding device. The interior of the reactor is used to hold a reaction solvent, and a first feeding port that can be opened and closed and a second feeding port that can be opened and closed are provided on the upper part of the reactor shell. The first feeding device is connected to the first feeding port of the reactor, and the first feeding device is used to feed the first material into the first feeding port in batches at a predetermined time interval. The second feeding device is connected to the second feeding port of the reactor, and the second feeding device is used to feed the second material into the second feeding port in batches at a predetermined time interval.
[0006] In an implementable solution, the first feeding device is a liquid material feeding device or a solid material feeding device; the second feeding device is a liquid material feeding device or a solid material feeding device.
[0007] In an implementable scheme, the liquid material feeding device includes a fixed bracket, a container, an intelligent switch valve and a first controller; the fixed bracket is fixedly set at a predetermined height, the container is installed on the fixed bracket, and the container is used to hold liquid material; an openable and closable liquid feeding port is set at the top of the container, and an outlet is set at the bottom and is used to connect with the first feeding port or the second feeding port; the intelligent switch valve is set at the outlet of the container, and the first controller is connected to the intelligent switch valve signal to control the opening and closing of the intelligent switch valve.
[0008] In an implementable scheme, the solid material feeding device includes a feed hopper, a conveying device, a receiving hopper and a second controller; the lower end of the receiving hopper is connected to the first feeding port or the second feeding port; the conveying device is horizontally arranged, including a first end and a second end, the feed hopper is installed on the conveying device and is at the first end of the conveying device, the feed hopper is used to hold solid materials and drop them onto the conveying device; the second end of the conveying device is above the receiving hopper; the second controller is connected to the conveying device signal to control the operation of the conveying device.
[0009] In an implementable solution, the solid material feeding device further includes a weighing sensor, the conveying device is mounted on the weighing sensor, and the weighing sensor is connected to the second controller signal; the weighing sensor is used to detect the overall mass of the conveying device, the feeding hopper and the solid material.
[0010] In an implementable scheme, the solid material feeding device also includes a sealed box, an openable and sealable feed port is arranged on the upper surface of the sealed box, and a discharge pipe port is arranged on the lower surface of the sealed box; the feed hopper, the conveying device and the receiving hopper are placed in the sealed box, and the opening of the feed hopper is opposite to the feed port, the outlet end of the receiving hopper extends from the discharge pipe port, and the contact position between the receiving hopper and the discharge pipe port is sealed.
[0011] In an implementable solution, an exhaust port and an air filling port are provided on the shell of the sealed box, the exhaust port is connected to an air pump, and the air filling port is connected to an inert gas supply device.
[0012] In an implementable solution, the conveying device is a conveyor belt conveying device, which includes a conveyor belt; the feeding hopper is arranged on the upper side of the first end of the conveyor belt conveying device, and the second end of the conveyor belt conveying device is above the receiving hopper.
[0013] In an implementable scheme, a plurality of grooves arranged in an array along the extension direction of the conveyor belt are provided on the surface of the conveyor belt; the bottom opening of the feed hopper is close to the surface of the conveyor belt; and perpendicular to the conveying direction of the conveyor belt, the width of the bottom opening of the feed hopper is smaller than the width of the conveyor belt and larger than the width of the grooves.
[0014] In an implementable scheme, the conveying device is a screw conveying device, which includes a driving device, a cylinder and a screw conveying structure; the cylinder includes a closed first end and an open second end; the screw conveying structure is placed in the cylinder and extends from the first end of the cylinder to the second end; the driving device is arranged at the first end of the cylinder and is connected to the screw conveying structure to drive the screw conveying structure to rotate; the second end of the cylinder is above the receiving hopper; an opening is arranged on the shell of the cylinder near its first end, and is sealed and docked with the bottom opening of the feeding hopper.
[0015] Compared with the prior art, the technical solution of the present application has at least the following beneficial effects:
[0016] When the batch feeding reaction equipment of the present application is used, the first material is placed in the first feeding device, the second material is placed in the second feeding device, and the reaction solvent is placed in the reactor. According to the ratio of the first material and the second material, the amount of material put into each time by the first feeding device and the second feeding device is set, and according to the reaction time of each batch of materials in the reactor, the time interval between each material addition of the first feeding device and the second feeding device is set. Afterwards, the first feeding device puts the first material into the first feeding port in batches at a predetermined time interval, and the second feeding device puts the second material into the second feeding port in batches at a predetermined time interval, thereby realizing the process of automatically adding reaction materials in batches, without the need for staff to weigh reaction materials, improving feeding efficiency, reducing the impact of human factors, and improving the control accuracy of reaction conditions. At the same time, it can also reduce the work risk of staff. BRIEF DESCRIPTION OF THE DRAWINGS
[0017] Figure 1 This is a schematic diagram of the overall structure of a batch-feeding reaction device provided according to an embodiment of the present application;
[0018] Figure 2 This is a schematic diagram of the specific structure of the first batch feeding reaction equipment provided according to an embodiment of the present application;
[0019] Figure 3 This is a schematic diagram of the specific structure of the second batch feeding reaction equipment provided according to an embodiment of the present application;
[0020] Figure 4 This is a schematic diagram of the specific structure of the third batch feeding reaction equipment provided according to an embodiment of the present application;
[0021] Figure 5 This is a schematic diagram of the specific structure of the fourth batch feeding reaction equipment provided according to an embodiment of the present application;
[0022] Figure 6 It is a structural schematic diagram of a first conveying device provided according to an embodiment of the present application;
[0023] Figure 7 for Figure 6 A schematic diagram of a three-dimensional structure of a conveying device in FIG.
[0024] Figure 8 for Figure 7 A schematic cross-sectional structure diagram of a conveying device in FIG.
[0025] Fig. 9 It is a schematic diagram of the structure of a second conveying device provided according to an embodiment of the present application.
[0026] In the figure: 10, reactor; 11, first feeding port; 12, second feeding port; 20, first feeding device; 30, second feeding device; 40, vacuum pump; 50, inert gas supply device; 60, conveyor belt conveying device; 61, conveyor belt; 62, groove; 70, screw conveying device; 71, driving device; 72, cylinder; 73, screw conveying structure; 100, liquid material feeding device; 101, fixed bracket; 102, container; 103, intelligent switch valve; 104, first controller; 200, solid material feeding device; 201, feeding hopper; 202, conveying device; 203, receiving hopper; 204, second controller; 205, weighing sensor; 206, sealing box; 2061, feeding port; 2062, discharge pipe port; 2063, exhaust port; 2064, charging port; 300, main controller. DETAILED DESCRIPTION
[0027] The technical solution of the present application is further explained below in conjunction with the specific implementation methods. However, it should be noted that the specific implementation methods are only a specific implementation and explanation of the essence of the technical solution of the present application, and should not be understood as a limitation on the protection scope of the present application.
[0028] The reagents and instruments used in the examples can all be purchased from commercial products, and the detection methods are conventional methods well known in the art.
[0029] like Figure 1 As shown, this embodiment provides a batch feeding reaction equipment, including a reaction kettle 10, a first feeding device 20 and a second feeding device 30.
[0030] The interior of the reactor 10 is used to hold the reaction solvent, and the upper part of the shell of the reactor 10 is provided with a first feed port 11 that can be opened and closed and a second feed port 12 that can be opened and closed. The first feed device 20 is connected to the first feed port 11 of the reactor 10, and the first feed device 20 is used to feed the first material into the first feed port 11 in batches at a predetermined time interval. The second feed device 30 is connected to the second feed port 12 of the reactor 10, and the second feed device 30 is used to feed the second material into the second feed port 12 in batches at a predetermined time interval.
[0031] When the batch feeding reaction equipment of this embodiment is used, the first material is placed in the first feeding device 20, the second material is placed in the second feeding device 30, and the reaction solvent is placed in the reactor 10. According to the ratio of the first material and the second material, the amount of material added each time by the first feeding device 20 and the second feeding device 30 is set, and according to the reaction time of each batch of materials in the reactor 10, the time interval for each addition of materials by the first feeding device 20 and the second feeding device 30 is set. Afterwards, the first feeding device 20 puts the first material into the first feeding port 11 in batches at a predetermined time interval, and the second feeding device 30 puts the second material into the second feeding port 12 in batches at a predetermined time interval, thereby realizing the process of automatically adding reaction materials in batches, without the need for staff to weigh the reaction materials, improving the feeding efficiency, reducing the impact of human factors, and improving the control accuracy of the reaction conditions. At the same time, it can also reduce the work risk of the staff.
[0032] In this embodiment, if Figure 2 As shown, the first feeding device 20 may be a solid material feeding device 200 , and the second feeding device 30 may be a liquid material feeding device 100 .
[0033] In this embodiment, if Figure 4 As shown, the first feeding device 20 and the second feeding device 30 may both be liquid material feeding devices 100 .
[0034] In this embodiment, if Figure 5 As shown, the first feeding device 20 and the second feeding device 30 may both be solid material feeding devices 200 .
[0035] like Figure 2 As shown, the liquid material feeding device 100 may include a fixed support 101, a container 102, an intelligent switch valve 103 and a first controller 104. The fixed support 101 is fixedly arranged at a predetermined height, and the container 102 is installed on the fixed support 101. The container 102 is used to contain liquid materials; a liquid feeding port that can be opened and closed is arranged on the top of the container 102, and an outlet is arranged at the bottom and is used to connect with the first feeding port 11 or the second feeding port 12; the intelligent switch valve 103 is arranged at the outlet of the container 102, and the first controller 104 is connected to the intelligent switch valve 103 by signal to control the opening and closing of the intelligent switch valve 103. The first controller 104 controls the opening time interval, the opening size and the opening time of the intelligent switch valve 103, so that the liquid material in the container 102 falls into the reactor 10 quantitatively according to the required time interval.
[0036] In this embodiment, the liquid material feeding device 100 can also adopt a solution of a container combined with a peristaltic pump (not shown in the figure). By controlling the opening time interval and the running time of the peristaltic pump, the liquid material in the container can be quantitatively extracted into the reactor 10 according to the required time interval.
[0037] like Figure 2 As shown, the solid material feeding device 200 may include a feed hopper 201, a conveyor 202, a receiving hopper 203, and a second controller 204. The lower end of the receiving hopper 203 is connected to the first feeding port 11 or the second feeding port 12. The conveyor 202 is horizontally arranged, including a first end and a second end. The feed hopper 201 is installed on the conveyor 202 and is located at the first end of the conveyor 202. The feed hopper 201 is used to hold solid materials and drop them onto the conveyor 202; the second end of the conveyor 202 is located above the receiving hopper 203. The second controller 204 is connected to the conveyor 202 by signal to control the operation of the conveyor 202. The second controller 204 controls the opening time interval, conveying speed, and each conveying time of the conveyor 202, so that the solid materials in the feed hopper 201 are quantitatively dropped into the reactor 10 according to the required time interval.
[0038] It should be noted that the solid materials mentioned above and below generally refer to powdered solid materials, that is, powdered solid materials with relatively uniform particle sizes.
[0039] In this embodiment, if Figure 6 As shown, the conveying device 202 can be a conveyor belt conveying device 60, and the conveyor belt conveying device 60 includes a conveyor belt 61. The feed hopper 201 is arranged on the upper side of the first end of the conveyor belt conveying device 60, and the second end of the conveyor belt conveying device 60 is located above the receiving hopper 203. During the rotation process of the conveyor belt 61, the solid material is taken out of the feed hopper 201 and sent to the feed hopper 201. By controlling the opening time interval, the rotation speed, and the rotation distance and rotation time of the conveyor belt 61, the solid material in the feed hopper 201 is quantitatively dropped into the reactor 10 according to the required time interval.
[0040] In this embodiment, if Figure 7 and Figure 8 As shown, the surface of the conveyor belt 61 can be provided with a plurality of grooves 62 arranged in an array along its extension direction, so that the bottom opening of the hopper 201 can be closely attached to the surface of the conveyor belt 61. In the conveying direction perpendicular to the conveyor belt 61, the bottom opening width of the hopper 201 is smaller than the width of the conveyor belt 61 and larger than the width of the grooves 62. During conveying, the solid materials in the hopper 201 fall into the grooves 62 and are conveyed out in sequence.
[0041] In this embodiment, if Figure 6As shown, the conveying device 202 can be a screw conveying device 70, which includes a driving device 71, a cylinder 72 and a screw conveying structure 73. The cylinder 72 includes a closed first end and an open second end; the screw conveying structure 73 is placed in the cylinder 72 and extends from the first end to the second end of the cylinder 72. The driving device 71 is arranged at the first end of the cylinder 72 and connected to the screw conveying structure 73 to drive the screw conveying structure 73 to rotate, and the second end of the cylinder 72 is above the receiving hopper 203; an opening is arranged on the shell of the cylinder 72 near its first end, and is sealed and docked with the bottom opening of the feeding hopper 201. Through the opening time interval, rotation speed, and each rotation time of the screw conveying structure 73, the solid material in the feeding hopper 201 is quantitatively screw-conveyed to the receiving hopper 203 according to the required time interval.
[0042] and Figure 2 In contrast, in this embodiment, Figure 3 As shown, the first controller 104 of the liquid material feeding device 100 and the second controller 204 of the solid material feeding device 200, as well as the controller controlling the reactor 10, can be uniformly controlled by a master controller 300, thereby realizing the overall operation of the entire device.
[0043] In this embodiment, if Figure 6 and Fig. 9 As shown, the solid material feeding device 200 can also include a weighing sensor 205, and the conveying device 202 is installed on the weighing sensor 205. The weighing sensor 205 is connected to the second controller 204 (or the main controller 300) by signal; the weighing sensor 205 is used to detect the overall mass of the conveying device 202, the feed hopper 201 and the solid material. After the conveying device 202 conveys the solid material to the receiving hopper 203, the overall mass of the conveying device 202, the feed hopper 201 and the solid material will decrease. When the second controller 204 (or the main controller 300) determines that the reduced mass reaches the required ratio of the material each time, the conveying device 202 is controlled to pause and wait for the next start.
[0044] In this embodiment, if Figure 6 and Fig. 9 As shown, the solid material feeding device 200 may further include a sealed box 206, the upper surface of which is provided with an openable and sealable feed port 2061, and the lower surface of which is provided with a discharge port 2062. The feed hopper 201, the conveying device 202 and the receiving hopper 203 are placed in the sealed box 206, and the opening of the feed hopper 201 faces the feed port 2061, the outlet end of the receiving hopper 203 extends from the discharge port 2062, and the contact position between the receiving hopper 203 and the discharge port 2062 is sealed. Figure 6 and Fig. 9As shown, an exhaust port 2063 and a gas filling port 2064 are provided on the shell of the sealed box 206, the exhaust port 2063 is connected to an air pump 40, and the gas filling port 2064 is connected to an inert gas supply device 50. For example, when the solid material is an active metal, after the solid material is put into the hopper 201 through the feed port 2061, the feed port 2061 is closed. Then the air pump 40 evacuates the air in the sealed box 206, and at the same time, the inert gas is transported into the sealed box 206 through the inert gas supply device 50 to protect the solid material.
[0045] For example, in a method for preparing anthraquinone, tetrahydrofuran is used as a solvent and heated to a preset temperature or above, and a reaction material is added to the heated tetrahydrofuran in a predetermined manner, and the reaction raw materials include ethyl o-iodobenzoate and magnesium metal. Ethyl o-iodobenzoate is liquid at room temperature, and magnesium metal can be in powder form. The mixing ratio of ethyl o-iodobenzoate and magnesium metal is approximately close to 1:1. In order to ensure the safety of the reaction and to prepare anthraquinone, ethyl o-iodobenzoate and magnesium metal need to be placed in tetrahydrofuran solvent in batches. The proportion of the reaction material added each time is about 1% to 4% of the total reaction material, and the reaction time of each batch of reaction raw materials is ≥8min.
[0046] Thus, when using the batch feeding reaction equipment of this embodiment, Figure 2 As shown, the required tetrahydrofuran solvent can be introduced into the reactor 10, the required ethyl o-iodobenzoate can be put into the container 102, and the metal magnesium can be introduced into the hopper 201. The intelligent switch valve 103 is opened once at least every 8 minutes to put a certain amount of ethyl o-iodobenzoate into the reactor 10, and the conveying device 202 is also started synchronously to convey the metal magnesium that meets the ratio requirement with ethyl o-iodobenzoate to the receiving hopper 203 and falls into the reactor 10, and the cycle is repeated and the feeding is automatically performed until the reaction is completed.
[0047] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit it. Although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present application.
Claims
1. A batch feeding reaction equipment, characterized in that: include: A reaction kettle (10) is used to contain a reaction solvent, and the upper part of the shell of the reaction kettle (10) is provided with a first feed port (11) and a second feed port (12) that can be opened and closed; A first feeding device (20) connected to the first feeding port (11) of the reaction kettle (10), the first feeding device (20) being used to feed the first material into the first feeding port (11) in batches at predetermined time intervals; The second feeding device (30) is connected to the second feeding port (12) of the reaction kettle (10), and the second feeding device (30) is used to feed the second material into the second feeding port (12) in batches at predetermined time intervals.
2. The batch feeding reaction equipment according to claim 1, characterized in that: The first feeding device (20) is a liquid material feeding device (100) or a solid material feeding device (200); The second feeding device (30) is a liquid material feeding device (100) or a solid material feeding device (200).
3. The batch feeding reaction equipment according to claim 2, characterized in that: The liquid material feeding device (100) comprises a fixed support (101), a container (102), an intelligent switch valve (103) and a first controller (104); The fixed support (101) is fixedly arranged at a predetermined height, the container (102) is mounted on the fixed support (101), and the container (102) is used to contain liquid materials; an openable and closable liquid adding port is arranged at the top of the container (102), and an outlet is arranged at the bottom and is used to be connected to the first feeding port (11) or the second feeding port (12); the intelligent switch valve (103) is arranged at the outlet of the container (102), and the first controller (104) is connected to the intelligent switch valve (103) by signal so as to control the opening and closing of the intelligent switch valve (103).
4. The batch feeding reaction equipment according to claim 2, characterized in that: The solid material feeding device (200) comprises a material feeding hopper (201), a conveying device (202), a material receiving hopper (203) and a second controller (204); The lower end of the receiving hopper (203) is connected to the first feeding port (11) or the second feeding port (12); The conveying device (202) is arranged horizontally, and comprises a first end and a second end; the feeding hopper (201) is installed on the conveying device (202) and is located at the first end of the conveying device (202); the feeding hopper (201) is used to hold solid materials and drop them onto the conveying device (202); the second end of the conveying device (202) is located above the receiving hopper (203); The second controller (204) is connected to the transmission device (202) by signals to control the operation of the transmission device (202).
5. The batch feeding reaction equipment according to claim 4, characterized in that: The solid material feeding device (200) further comprises a weighing sensor (205), the conveying device (202) is mounted on the weighing sensor (205), and the weighing sensor (205) is connected to the second controller (204) by signal; the weighing sensor (205) is used to detect the overall mass of the conveying device (202), the feeding hopper (201) and the solid material.
6. The batch feeding reaction equipment according to claim 4, characterized in that: The solid material feeding device (200) further comprises a sealing box (206), wherein an openable and sealable material inlet (2061) is arranged on the upper surface of the sealing box (206), and a material outlet (2062) is arranged on the lower surface of the sealing box (206); The feed hopper (201), the conveying device (202) and the receiving hopper (203) are placed in the sealing box (206), and the opening of the feed hopper (201) is opposite to the feed port (2061), the outlet end of the receiving hopper (203) extends from the discharge pipe port (2062), and the contact position between the receiving hopper (203) and the discharge pipe port (2062) is sealed.
7. The batch-feeding reaction equipment according to claim 6, characterized in that: An exhaust port (2063) and an air filling port (2064) are provided on the shell of the sealing box (206); the exhaust port (2063) is connected to an air pump (40), and the air filling port (2064) is connected to an inert gas supply device (50).
8. The batch-feeding reaction equipment according to any one of claims 4 to 7, characterized in that: The conveying device (202) is a conveyor belt conveying device (60), and the conveyor belt conveying device (60) comprises a conveyor belt (61); The feeding hopper (201) is arranged on the upper side of the first end of the conveyor belt conveying device (60), and the second end of the conveyor belt conveying device (60) is located above the receiving hopper (203).
9. The batch feeding reaction equipment according to claim 8, characterized in that: The surface of the conveyor belt (61) is provided with a plurality of grooves (62) arranged in an array along its extension direction; The bottom opening of the feed hopper (201) is in close contact with the surface of the conveyor belt (61); In a direction perpendicular to the conveying direction of the conveyor belt (61), the width of the bottom opening of the feed hopper (201) is smaller than the width of the conveyor belt (61) and larger than the width of the groove (62).
10. The batch-feeding reaction equipment according to any one of claims 4 to 7, characterized in that: The conveying device (202) is a screw conveying device (70), and the screw conveying device (70) comprises a driving device (71), a cylinder (72) and a screw conveying structure (73); The cylinder (72) comprises a closed first end and an open second end; the spiral conveying structure (73) is disposed in the cylinder (72) and extends from the first end to the second end of the cylinder (72); The driving device (71) is arranged at the first end of the cylinder (72) and connected to the spiral conveying structure (73) to drive the spiral conveying structure (73) to rotate; The second end of the cylinder (72) is located above the receiving hopper (203); An opening is provided on the shell of the cylinder (72) near its first end, and is sealed and docked with the bottom opening of the feed hopper (201).