Ultrasonic mixing device

Abstract

The utility model discloses an ultrasonic uniform mixing device which comprises a base, a fixing support, an ultrasonic driver, an ultrasonic vibrator, a lifting mechanism, a pressing assembly and a sample container, a containing cavity is formed in the fixing support, and a through hole is formed in the wall face, away from the base, of the containing cavity; the ultrasonic driver is fixedly mounted in the accommodating cavity; the ultrasonic vibrator is inserted into the through hole and is electrically connected with the ultrasonic driver; the lifting mechanism is fixedly mounted on the base; the pressing assembly is fixedly connected with the lifting mechanism. The sample container is arranged between the pressing assembly and the ultrasonic vibrator, and the axes of the ultrasonic vibrator, the pressing assembly and the sample container coincide. The sample container and the ultrasonic vibrator are pressed through the lifting mechanism and the pressing assembly, then the ultrasonic driver and the ultrasonic vibrator convert low-frequency alternating current into high-frequency electric energy, and then the high-frequency electric energy is converted into ultrasonic vibration, so that samples in the sample container are fully mixed or broken, and the mixing or breaking effect of the biological samples is enhanced.

Description

Technical Field

[0001] The present application relates to the technical field of biomedical analysis equipment, and in particular to an ultrasonic mixing device. Background Art

[0002] In the biomedical field, sample mixing and disruption are critical steps in daily laboratory operations. Traditional mixing and disruption methods, such as mechanical stirring, centrifugation, and high-pressure homogenization, are effective but may be complex, inefficient, or cause excessive damage to the sample.

[0003] For example: In the prior art, the hemoglobin analyzer is a fully automated instrument that integrates automatic sampling, mixing, sampling, dilution and detection. The above sampling refers to the process in which the sampling needle of the instrument pierces the cap of the vacuum blood collection tube to absorb a trace amount of anticoagulated whole blood sample, which is very critical for the accurate sampling of whole blood. Inaccurate sampling affects the detection accuracy and precision of the sample. There are many factors for inaccurate sampling, among which the key factor is how to fully mix the anticoagulated whole blood in the vacuum blood collection tube. The existing common mixing method is to use the top pressure test tube cap to rotate at high speed for mixing. This method has a long stirring time, large mechanical wear and high noise. Sometimes, due to the different sizes and diameters of the blood collection tube caps, it is possible that the blood collection tube cannot be rotated. Obviously, this method has problems such as low efficiency and poor mixing effect. Utility Model Content

[0004] The main purpose of the present application is to provide an ultrasonic mixing device, aiming to solve the problems of low efficiency and poor effect of mixing and cell rupture of biomedical samples.

[0005] To achieve the above-mentioned purpose, the present application provides an ultrasonic mixing device, comprising a base, a fixed bracket, an ultrasonic driver, an ultrasonic vibrator, a lifting mechanism, a clamping assembly and a sample container, wherein the fixed bracket is fixedly installed on the base, a receiving cavity is formed in the fixed bracket, and a through hole is opened on the wall of the receiving cavity away from the base; the ultrasonic driver is fixedly installed in the receiving cavity; the ultrasonic vibrator is inserted in the through hole and is electrically connected to the ultrasonic driver; the lifting mechanism is fixedly installed on the base; the clamping assembly is fixedly connected to one end of the lifting mechanism away from the base, and is arranged opposite to the ultrasonic vibrator in the extension direction of the lifting mechanism; the sample container is arranged between the clamping assembly and the ultrasonic vibrator, and the axes of the ultrasonic vibrator, the clamping assembly and the sample container coincide.

[0006] Optionally, the lifting mechanism includes: a shell, a screw assembly, a driving assembly, a lifting shaft and a connecting piece, wherein the shell is arranged on the base; the screw assembly includes a screw arranged in the shell and a slider sleeved on the screw, and the slider is threadedly matched with the screw; the driving assembly is arranged on the base and located in the shell, the driving assembly includes a driving piece and a coupling, and the screw is connected to the output end of the driving piece through the coupling; one end of the lifting shaft is fixedly connected to a side of the slider away from the base; the connecting piece is fixedly connected to the other end of the lifting shaft and extends in a direction perpendicular to the extension direction of the lifting shaft, and a mounting hole is provided at one end of the connecting piece away from the lifting shaft.

[0007] Optionally, the clamping assembly includes: a clamping member and an elastic member, wherein the mounting hole opened on the lifting shaft is slidably sleeved on the outer wall surface of the clamping member, and one end of the clamping member extends out of the mounting hole along the axial direction of the clamping member, and forms a first protrusion on the upper surface of the connecting member; the elastic member is movably sleeved on the outer wall surface of the clamping member, and abuts against the lower surface of the connecting member and the second protrusion formed on the other end of the clamping member.

[0008] Optionally, the elastic member is a spring.

[0009] Optionally, the outer diameter of the sample container is equal to the inner diameter of the pressing member, and a third protrusion is formed on the outer wall of the sample container close to the pressing member along the circumference of the sample container, and the third protrusion abuts against the second protrusion during pressing.

[0010] Optionally, the ultrasonic mixing device further comprises: a fixed support plate; the fixed support plate is fixedly mounted on the base and is located between the lifting mechanism and the fixed bracket; a sliding groove is provided at one end of the fixed support plate away from the base, and the connecting member slides up and down in the sliding groove.

[0011] Optionally, the sample container is a cylindrical structure with an inverted truncated cone-shaped bottom.

[0012] Optionally, a fixed sub-plate is disposed on the fixed support plate, one end of the fixed sub-plate is fixedly connected to the fixed support plate and the other end of the fixed sub-plate is provided with a circular hole, and the circular hole is movably sleeved on the outer wall surface of the sample container.

[0013] Optionally, an elastic ring is provided on the inner wall surface of the circular hole, and the elastic ring abuts against the inner wall surface of the circular hole and the outer wall surface of the sample container.

[0014] Optionally, the driving member is a stepping motor.

[0015] An ultrasonic mixing device proposed in an embodiment of the present application realizes the installation of an ultrasonic driver, an ultrasonic vibrator, a lifting mechanism, a clamping assembly and a sample container through the cooperation of a base and a fixed bracket. First, the sample container and the ultrasonic vibrator are clamped together by the lifting mechanism and the clamping assembly, and then the ultrasonic driver is energized. The ultrasonic driver converts low-frequency alternating current into high-frequency electrical energy and outputs it to the ultrasonic vibrator. The ultrasonic vibrator then converts the high-frequency electrical energy into ultrasonic vibrations, thereby mixing or rupturing the sample in the sample container. The above-mentioned settings can achieve sufficient mixing or rupture of biomedical samples and greatly enhance the mixing or rupture effect of biomedical samples. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 A schematic diagram of the structure of an ultrasonic mixing device provided in an embodiment of the present application;

[0017] Figure 2 for Figure 1 The schematic diagram of the cross-sectional structure of the ultrasonic mixing device shown along the AA' direction;

[0018] Figure 3 for Figure 2 The schematic diagram of the structure of the lead screw assembly and the driving assembly of the ultrasonic mixing device is shown.

[0019] Figure numerals: 1. base; 2. fixed bracket; 21. receiving chamber; 3. ultrasonic driver; 4. ultrasonic vibrator; 5. lifting mechanism; 51. shell; 52. screw assembly; 521. screw; 522. slider; 53. driving assembly; 531. driving member; 532. coupling; 54. lifting shaft; 55. connecting member; 6. clamping assembly; 61. clamping member; 62. elastic member; 611. first protrusion; 612. second protrusion; 7. sample container; 71. third protrusion; 8. fixed support plate; 81. sliding groove; 82. fixed sub-plate.

[0020] The realization of the purpose, functional features and advantages of this application will be further explained in conjunction with embodiments and with reference to the accompanying drawings. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0022] It should be noted that all directional indications in the embodiments of the present application (such as up, down, left, right, front, back, etc.) are only used to explain the relative position relationship, movement status, etc. between the components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indication will also change accordingly.

[0023] In this application, unless otherwise clearly specified and limited, the terms "connection", "fixation", etc. should be understood in a broad sense. For example, "fixation" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0024] In addition, if there are descriptions involving "first", "second", etc. in the embodiments of the present application, the descriptions of "first", "second", etc. are only used for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of technical features indicated. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In addition, the meaning of "and / or" appearing in the full text includes three parallel schemes. Taking "A and / or B" as an example, it includes scheme A, or scheme B, or a scheme that satisfies both A and B. In addition, the technical solutions between the various embodiments can be combined with each other, but it must be based on the ability of ordinary technicians in the field to implement. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection required by this application.

[0025] The present application is described in detail below with reference to the accompanying drawings and embodiments.

[0026] Figure 1 This is a schematic diagram of the structure of the ultrasonic mixing device provided in the embodiment of the present application. Figure 2 for Figure 1 The schematic diagram of the cross-sectional structure of the ultrasonic mixing device along the AA' direction is shown. Figure 3 for Figure 2 The schematic diagram of the structure of the lead screw assembly and the driving assembly of the ultrasonic mixing device is shown.

[0027] Please combine Figure 1 and Figure 2For reference, an embodiment of the present application provides an ultrasonic mixing device, which may include a base 1, a fixed bracket 2, an ultrasonic driver 3, an ultrasonic vibrator 4, a lifting mechanism 5, a clamping assembly 6 and a sample container 7, wherein the fixed bracket 2 is fixedly installed on the base 1, a receiving cavity 21 is formed in the fixed bracket 2, and a through hole is opened on the wall of the receiving cavity 21 away from the base 1; the ultrasonic driver 3 is fixedly installed in the receiving cavity 21; the ultrasonic vibrator 4 is inserted in the through hole and electrically connected to the ultrasonic driver 3; the lifting mechanism 5 is fixedly installed on the base 1; the clamping assembly 6 is fixedly connected to one end of the lifting mechanism 5 away from the base 1, and is arranged opposite to the ultrasonic vibrator 4 in the extension direction of the lifting mechanism 5; the sample container 7 is arranged between the clamping assembly 6 and the ultrasonic vibrator 4, and the axes of the ultrasonic vibrator 4, the clamping assembly 6 and the sample container 7 coincide.

[0028] Specifically, the installation of the ultrasonic driver 3, the ultrasonic vibrator 4, the lifting mechanism 5, the clamping assembly 6 and the sample container 7 is realized by the cooperation between the base 1 and the fixed bracket 2. First, the sample container 7 and the ultrasonic vibrator 4 are clamped by the lifting mechanism 5 and the clamping assembly 6, and then the ultrasonic driver 3 is energized, and the low-frequency alternating current is converted into high-frequency electrical energy by the ultrasonic driver 3 and output to the ultrasonic vibrator 4, and then the high-frequency electrical energy is converted into ultrasonic vibration by the ultrasonic vibrator 4, so that the sample in the sample container 7 is mixed or ruptured; through the above-mentioned settings, sufficient mixing or rupture of the biomedical sample is achieved, and the mixing or rupture effect of the biomedical sample is greatly enhanced.

[0029] Furthermore, the fixing bracket 2 is provided with a connection hole for electrically connecting the ultrasonic driver 3 to an external power source, so as to facilitate operation.

[0030] Please combine Figure 2 and Figure 3 For reference, in an exemplary embodiment, the lifting mechanism 5 may include a shell 51, a lead screw assembly 52, a drive assembly 53, a lifting shaft 54 ​​and a connecting member 55, wherein the shell 51 is arranged on the base 1; the lead screw assembly 52 includes a lead screw 521 arranged in the shell 51 and a slider 522 sleeved on the lead screw 521, and the slider 522 is threadedly matched with the lead screw 521; the drive assembly 53 is arranged on the base 1 and located in the shell 51, and the drive assembly 53 may include a driving member 531 and a coupling 532, and the lead screw 521 is connected to the output end of the driving member 531 through the coupling 532; one end of the lifting shaft 54 ​​is fixedly connected to the side of the slider 522 away from the base 1; the connecting member 55 is fixedly connected to the other end of the lifting shaft 54, and extends in a direction perpendicular to the extension direction of the lifting shaft 54, and a mounting hole is provided at one end of the connecting member 55 away from the lifting shaft 54.

[0031] Specifically, the housing 51 is used to protect the lead screw assembly 52 and the drive assembly 53 to protect them from damage and extend their service life. Driven by the drive assembly 53, the lead screw assembly 52 can drive the clamping assembly 6 to perform linear motion in the vertical direction to complete the clamping of the sample container 7, so that the biological sample can be more fully mixed or broken. Exemplarily, the above-mentioned biological samples can include whole blood samples, plasma and serum samples, urine samples, saliva samples, tissue samples, cell culture samples, stool samples, bone marrow samples, and cerebrospinal fluid samples.

[0032] Exemplarily, the driving member 531 may be a stepping motor.

[0033] Specifically, when the pressing assembly 6 is required to press the sample container 7, the driving member 531 is started to provide power to the lead screw assembly 52, and the power is transmitted to the lead screw 521 through the coupling 532. The rotation of the lead screw 521 causes the slider 522 to move up and down along the lead screw 521. The movement of the slider 522 further drives the lifting shaft 54 ​​to move up and down together, and the connecting member 55 can be used to fix the pressing assembly 6 to move up and down.

[0034] The lifting mechanism 5 can achieve precise vertical lifting motion through the threaded fit of the lead screw assembly 52 and the power transmission of the drive assembly 53. The design of the lead screw assembly 52 and the slider 522 can provide stable lifting motion, ensuring stability and reliability during the lifting process.

[0035] Please continue reading Figure 1 In an exemplary embodiment, the clamping assembly 6 may include a clamping member 61 and an elastic member 62, wherein the mounting hole opened on the lifting shaft 54 ​​is slidably sleeved on the outer wall surface of the clamping member 61, and one end of the clamping member 61 extends out of the mounting hole along the axial direction of the clamping member 61, and forms a first protrusion 611 on the upper surface of the connecting member 55; the elastic member 62 is movably sleeved on the outer wall surface of the clamping member 61, and abuts against the second protrusion 612 formed on the lower surface of the connecting member 55 and the other end of the clamping member 61.

[0036] Specifically, when the pressing assembly 6 presses the sample container 7 , the pressing member 61 slides upward in the axial direction of the mounting hole under the action of the elastic member 62 , and the elastic member 62 is in a contracted state.

[0037] Exemplarily, the elastic member 62 may be a spring. The spring has excellent elastic deformation capability and large elastic force. The spring is used to abut the lower surface of the connecting member 55 and the second protrusion 612 formed at the other end of the pressing member 61, and the abutting effect is good. In addition, the spring can store and release energy, realize buffering and shock absorption, and provide a constant or variable reaction force to enable the pressing member 61 to stably clamp the sample container 7, thereby ensuring the stability of the operation of the ultrasonic mixing device.

[0038] In some embodiments, the outer diameter of the sample container 7 is equal to the inner diameter of the clamping member 61 , and a third protrusion 71 is formed on the outer wall of the sample container 7 close to the clamping member 61 along the circumference of the sample container 7 , and the third protrusion 71 abuts against the second protrusion 612 when clamped.

[0039] Specifically, when the pressing assembly 6 presses the sample container 7, the outer wall surface of the sample container 7 above the third protrusion 71 fits exactly with the inner wall surface of the pressing member 61, and the third protrusion 71 abuts against the second protrusion 612. While the sample container 7 is pressed, the sample container 7 is further fixed, and the biological sample in the sample container 7 is prevented from splashing out of the sample container 7 during ultrasonic mixing.

[0040] In some embodiments, the ultrasonic mixing device may further include a fixed support plate 8; the fixed support plate 8 is fixedly mounted on the base 1 and is located between the lifting mechanism 5 and the fixed bracket 2; a sliding groove 81 is provided at one end of the fixed support plate 8 away from the base 1, and the connecting member 55 slides up and down in the sliding groove 81.

[0041] When the lifting mechanism 5 drives the pressing assembly 6 to press the sample container 7, the connecting member 55 slides downward in the sliding groove 81, and the sliding groove 81 restricts the connecting member 55, so that the operation of the pressing member 61 is more stable and more accurate.

[0042] like Figure 1 and Figure 2 As shown, in an exemplary embodiment, the sample container 7 may be a cylindrical structure with an inverted truncated cone-shaped bottom.

[0043] Exemplarily, the material of the sample container 7 may be plastic, glass, etc.

[0044] Specifically, the bottom of the sample container 7 is in the shape of an inverted truncated cone, which can promote the reflection and refraction of ultrasonic waves in the sample container 7, increase the reflection area and path of the sound waves, and thus improve the mixing effect of the biological sample. It can be understood that sound waves are more likely to produce reflection and focusing effects on the conical surface, which optimizes the propagation path and propagation speed of the sound waves, so that the sound energy is more effectively transmitted to the liquid in the sample container 7, thereby improving the mixing effect and making the liquid more evenly mixed.

[0045] Meanwhile, compared with a flat-bottom container, the bottom of the sample container 7 is in the shape of an inverted frustum, which can reduce the splashing and fluctuation of the liquid when the ultrasonic wave acts, and keep the operating environment clean and safe.

[0046] The frustum-shaped bottom design is usually easier to clean and less likely to leave sample or other substances, which is beneficial for operation and accuracy the next time it is used. In turn, it can effectively improve the efficiency and consistency of the results during ultrasonic mixing.

[0047] In some embodiments, a fixed sub-plate 82 is disposed on the fixed support plate 8 , one end of the fixed sub-plate 82 is fixedly connected to the fixed support plate 8 and the other end is provided with a circular hole, which is movably sleeved on the outer wall of the sample container 7 .

[0048] Furthermore, an elastic ring is provided along the inner wall of the circular hole, and the elastic ring abuts against the inner wall of the circular hole and the outer wall of the sample container 7 .

[0049] The ultrasonic driver 3 converts electrical energy into an alternating current signal that matches the ultrasonic vibrator 4, driving the ultrasonic vibrator 4 to work. The ultrasonic vibrator 4 converts electrical power into ultrasonic waves, thereby mixing and breaking the biological sample in the sample container 7. The elastic ring offsets the vibration generated by the ultrasonic vibrator 4 during operation, reducing the damage caused by the vibration to the fixed support plate 8. At the same time, the elastic ring is squeezed by the sample container 7 to clamp the sample container 7 well, preventing the working vibration of the ultrasonic vibrator 4 from affecting the sample container 7, and has strong practicality.

[0050] The above are only preferred embodiments of the present application, and are not intended to limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made using the contents of the present application specification and drawings, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. An ultrasonic mixing device, characterized in that: include: Base (1); A fixed bracket (2) is fixedly mounted on the base (1), a receiving cavity (21) is formed in the fixed bracket (2), and a through hole is formed on a wall of the receiving cavity (21) away from the base (1); An ultrasonic driver (3) fixedly mounted in the receiving cavity (21); An ultrasonic vibrator (4) is inserted into the through hole and electrically connected to the ultrasonic driver (3); A lifting mechanism (5) is fixedly mounted on the base (1); A pressing assembly (6) is fixedly connected to an end of the lifting mechanism (5) away from the base (1), and is arranged opposite to the ultrasonic vibrator (4) in the extension direction of the lifting mechanism (5); The sample container (7) is arranged between the pressing component (6) and the ultrasonic vibrator (4), and the axes of the ultrasonic vibrator (4), the pressing component (6) and the sample container (7) coincide with each other.

2. The ultrasonic mixing device according to claim 1, characterized in that: The lifting mechanism (5) comprises: A housing (51) is disposed on the base (1); A lead screw assembly (52) comprises a lead screw (521) disposed in the housing (51) and a slider (522) sleeved on the lead screw (521), wherein the slider (522) is threadably matched with the lead screw (521); A drive assembly (53) is arranged on the base (1) and is located in the housing (51), the drive assembly (53) comprising a drive member (531) and a coupling (532), the lead screw (521) being connected to an output end of the drive member (531) via the coupling (532); A lifting shaft (54), one end of which is fixedly connected to a side of the sliding block (522) away from the base (1); The connecting member (55) is fixedly connected to the other end of the lifting shaft (54) and extends in a direction perpendicular to the extension direction of the lifting shaft (54). A mounting hole is provided at one end of the connecting member (55) away from the lifting shaft (54).

3. The ultrasonic mixing device according to claim 2, characterized in that: The pressing assembly (6) comprises: A clamping member (61) is provided with a mounting hole on the lifting shaft (54) and is slidably sleeved on an outer wall surface of the clamping member (61), and one end of the clamping member (61) extends out of the mounting hole along the axial direction of the clamping member (61), and a first protrusion (611) is formed on the upper surface of the connecting member (55); The elastic member (62) is movably sleeved on the outer wall surface of the pressing member (61) and abuts against the lower surface of the connecting member (55) and the second protruding portion (612) formed at the other end of the pressing member (61).

4. The ultrasonic mixing device according to claim 3, characterized in that: The elastic member (62) is a spring.

5. The ultrasonic mixing device according to claim 3, characterized in that: The outer diameter of the sample container (7) is equal to the inner diameter of the pressing piece (61), and a third protrusion (71) is formed on the outer wall surface of the sample container (7) close to the pressing piece (61) along the circumference of the sample container (7). When pressed, the third protrusion (71) abuts against the second protrusion (612).

6. The ultrasonic mixing device according to claim 2, characterized in that: Also includes: A fixed support plate (8) fixedly mounted on the base (1) and located between the lifting mechanism (5) and the fixed support (2); A sliding groove (81) is provided at one end of the fixed support plate (8) away from the base (1), and the connecting member (55) slides up and down in the sliding groove (81).

7. The ultrasonic mixing device according to claim 1, characterized in that: The sample container (7) is a cylindrical structure with an inverted truncated cone-shaped bottom.

8. The ultrasonic mixing device according to claim 6, characterized in that: The fixed support plate (8) is provided with a fixed sub-plate (82), one end of the fixed sub-plate (82) is fixedly connected to the fixed support plate (8) and the other end is provided with a circular hole, and the circular hole is movably sleeved on the outer wall surface of the sample container (7).

9. The ultrasonic mixing device according to claim 8, characterized in that: An elastic ring is provided on the inner wall surface of the circular hole, and the elastic ring abuts against the inner wall surface of the circular hole and the outer wall surface of the sample container (7).

10. The ultrasonic mixing device according to claim 9, characterized in that: The driving member (531) is a stepping motor.

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