Eight-channel dry-type fluorescence analyzer

Abstract

The utility model provides an eight-channel dry-type fluorescence analyzer which comprises a shell and a fluorescence detection head used for detecting a reagent card, the fluorescence detection head is movably arranged in the shell, a detection clamping plate is arranged in the shell, a clamping plate displacement assembly used for moving the detection clamping plate is movably arranged in the shell, and the detection clamping plate is movably arranged in the shell. Eight card supports are arranged on the detection card plate in parallel, each card support is movably connected to the detection card plate, eight microswitches which are in one-to-one correspondence with the card supports and are used for detecting whether reagent cards are inserted or not are arranged on the detection card support, and a sensor for positioning the positions of the reagent cards is arranged on the detection displacement assembly. An identification probe for scanning codes of the reagent card and a detection controller for receiving and analyzing data are arranged in the shell. The kit can be used for simultaneously detecting eight reagent cards, identifying codes of the reagent cards in batches, quickly recording detection data and improving the detection efficiency and the data analysis precision.

Description

Technical Field

[0001] The utility model relates to the technical field of optical instruments, and in particular to an 8-channel dry fluorescence analyzer. Background Art

[0002] A dry fluorescence analyzer is a highly sensitive and highly specific biological analysis instrument, often used to measure bioactive compounds with very low contents, such as proteins, hormones, drugs, and microorganisms. The operation process of a dry fluorescence immunoassay analyzer usually includes three aspects: sample processing, reagent packaging, and data analysis. First, the sample to be tested is added to the reagent pack of the dry fluorescence immunoassay analyzer and reacts with the reagent, then it is put into the dry fluorescence immunoassay analyzer for detection, and finally, the results are read and processed by the software in the dry fluorescence analyzer.

[0003] Dry fluorescence analyzers have a wide range of applications in the fields of medicine, food safety, environmental monitoring, etc. For example, in the field of medical testing, they can be used for cancer screening, detection of infected viruses, determination of drug metabolism levels, etc.; in the field of food safety, they can be used to detect harmful substances such as pesticides and heavy metals remaining in food; in the field of environmental monitoring, they can be used to detect pollutants in water bodies or bacteria in the air. At the same time, dry fluorescence analyzers are also widely used in laboratory research and can be used for the detection of biomolecules such as proteins and antibodies.

[0004] The existing Chinese patent named dry immuno-fluorescence instrument with the patent number CN202916202U, when in use, only needs to insert the reagent strip into the reagent strip slot, and the steel ball will cooperate with the counterbore on the lower surface of the reagent strip to accurately position the reagent strip and prevent its position deviation. Then the motor starts, and through the driving pulley, toothed transmission belt, and connecting piece, the slider moves along the slideway, and the positioning sensor can ensure the movement accuracy. When the slider drives the reagent strip to move to the optical detector, the relevant detection can be completed. Although the above existing technology can accurately cooperate with the optical detector through moving positioning for detection, thereby ensuring the detection accuracy, it can only detect one reagent strip at a time and cannot identify and record the reagent strip. When the number of reagent strips to be detected is large, it is easy to cause confusion in the detection results and is not convenient for data induction and analysis. Summary of the Utility Model

[0005] The purpose of the utility model is to overcome the deficiencies of the above traditional technologies, and provide an 8-channel dry fluorescence analyzer, which can detect 8 reagent cards simultaneously, and can batch-identify the reagent card codes, quickly record the detection data, and improve the detection efficiency and data analysis accuracy.

[0006] The purpose of the utility model is achieved by the following technical measures:

[0007] 8-channel dry fluorescence analyzer, including a housing and a fluorescence detection head for detecting reagent cards. The fluorescence detection head is movably arranged in the housing. A detection card board is arranged in the housing. A card board displacement component for moving the detection card board is movably arranged in the housing. The detection card board is connected to the card board displacement component. 8 card holders are arranged in parallel on the detection card board. Each card holder is movably connected to the detection card board. 8 micro switches corresponding to the card holders one by one are arranged on the detection card holder for detecting whether the reagent card is inserted. A detection displacement component for moving the fluorescence detection head is arranged in the housing. A sensor for positioning the position of the reagent card is arranged on the detection displacement component. An identification probe for scanning the code of the reagent card and a detection controller for receiving and analyzing data are arranged in the housing. The identification probe, the fluorescence detection head, the sensor, the micro switch, the card board displacement component and the detection displacement component are all electrically connected to the detection controller.

[0008] Further specifically optimized, an elastic sheet for fixing the reagent card is fixedly connected to each micro switch, and the elastic sheet is movably connected to the reagent card.

[0009] Further specifically optimized, a detection frame for inserting the detection card board is opened on the side wall of the housing. A card board push groove adapted to the detection frame is fixedly connected to the side of the detection card. The card board push groove is slidably connected in the detection frame. 8 channel bayonets corresponding to the card holders are opened on the card board push groove.

[0010] Further specifically optimized, a bottom heating plate is fixedly connected to the bottom of the detection card board. An arched heating plate is arranged on one side of the housing close to the detection frame. The detection card board is movably connected below the arched heating plate.

[0011] Further specifically optimized, the card board displacement component includes a first motor, a card board drive belt and a card board fixed clamp. The first motor is fixedly arranged in the housing. The card board fixed clamp is fixedly connected to the detection card board. The first motor drives the card board drive belt to rotate. The card board fixed clamp is clamped on the card board drive belt. The first motor is electrically connected to the detection controller.

[0012] Further specifically optimized, a card board displacement slider is fixedly connected to the bottom of the detection card board. A card board displacement chute for cooperating with the card board displacement slider to keep the movement of the detection card board stable is fixedly connected in the housing. The card board displacement slider is slidably connected on the card board displacement chute.

[0013] For further specific optimization, the detection displacement assembly includes a second motor, a detection drive belt, and a detection fixed clamp. The second motor is fixedly connected inside the housing. The second motor drives the detection drive belt to rotate. The detection fixed clamp is clamped on the detection drive belt. A connecting plate is fixedly connected to the detection fixed clamp. The fluorescence detection head and the sensor are both fixedly connected below the connecting plate and on one side close to the detection card plate. The second motor is electrically connected to the detection controller.

[0014] For further specific optimization, a detection displacement chute is provided inside the housing. Both sides of the detection displacement chute are fixedly connected to the inside of the housing through fixing brackets. A detection displacement slider is slidably connected to the detection displacement chute. The fluorescence detection head and the sensor are both fixedly connected to the detection displacement slider.

[0015] Due to the adoption of the above technical solutions, compared with the prior art, the advantages of the present utility model are as follows:

[0016] The present utility model discloses an 8-channel dry fluorescence analyzer. Through the cooperation of 8 channel bayonets and 8 cartridges, multiple reagent cards can be detected simultaneously. Moreover, the reaction speed of the reagent cards can be increased and the reaction time can be shortened by means of the arched heating plate and the bottom heating plate, thereby improving the detection efficiency.

[0017] The reagent card codes can be batch-identified by the identification probe. The detection controller adjusts the detection card plate and performs rapid detection by moving the fluorescence detection head and the sensor, and batch-records the detection data, improving the detection efficiency and the data analysis accuracy.

[0018] The following further illustrates the present utility model in conjunction with the accompanying drawings and specific embodiments. Description of the Drawings

[0019] Figure 1 is the overall structural schematic diagram of the embodiment of the present utility model.

[0020] Figure 2 is the structural schematic diagram of another angle of the embodiment of the present utility model.

[0021] Figure 3 is the partial structural schematic diagram of the embodiment of the present utility model.

[0022] Figure 4 is the structural schematic diagram of the reagent card inserted into the cartridge in the embodiment of the present utility model.

[0023] Figure 5 is the structural schematic diagram of the detection card plate and the bottom heating plate in the embodiment of the present utility model.

[0024] Figure 6 is Figure 2 the enlarged structural schematic diagram of part A in

[0025] Figure 7 It is a schematic structural diagram of the reagent card described in the present utility model.

[0026] Markings in the figure: 1. Housing; 2. Fluorescence detection head; 3. Sensor; 4. Detection card board; 41. Card holder; 42. Microswitch; 43. Elastic sheet; 5. Card board displacement assembly; 51. First motor; 52. Card board drive belt; 53. Card board fixed clamp; 6. Detection displacement assembly; 61. Second motor; 62. Detection drive belt; 63. Detection fixed clamp; 7. Identification probe; 8. Detection controller; 9. Bottom heating plate; 10. Arch heating plate; 11. Card board push groove; 12. Channel bayonet; 13. Card board displacement chute; 14. Card board displacement slider; 15. Detection displacement chute; 16. Detection displacement slider; 17. Connecting plate. Detailed implementation manners

[0027] In order to clearly and completely describe the purpose, technical solution of the present utility model and make the advantages more clear, the following further details the embodiments of the present utility model with reference to the accompanying drawings. It should be understood that the specific embodiments described herein are part of the embodiments of the present utility model, rather than all of the embodiments, and are only used to explain the embodiments of the present utility model, not to limit the embodiments of the present utility model. All other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the protection scope of the present utility model.

[0028] In the description of the present utility model, it should be noted that the orientation or positional relationship indicated by the terms "center", "middle", "upper", "lower", "left", "right", "inner", "outer", "top", "bottom", "side", "vertical", "horizontal", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus cannot be understood as a limitation of the present utility model. In addition, the terms "one", "first", "second", "third", "fourth", "fifth", "sixth" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0029] In the description of the present utility model, it should be noted that unless otherwise clearly specified and limited, the terms "installation", "connection", "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the internal communication of two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific situations.

[0030] For the purposes of simplicity and illustration, the principles of the embodiments are mainly described by reference to examples. In the following description, many specific details are set forth to provide a thorough understanding of the embodiments. However, it is obvious that, for those of ordinary skill in the art, these embodiments may not be limited to these specific details in practice. In some instances, well-known methods and structures are not described in detail so as not to unnecessarily obscure these embodiments. Additionally, all embodiments may be used in combination with each other.

[0031] Embodiment:

[0032] An 8-channel dry fluorescence analyzer, comprising a housing 1 and a fluorescence detection head 2 for detecting reagent cards. The fluorescence detection head 2 is movably arranged in the housing 1. A detection card plate 4 is arranged in the housing 1. A card plate displacement assembly 5 for moving the detection card plate 4 is movably arranged in the housing 1. The detection card plate 4 is connected to the card plate displacement assembly 5. Eight card holders 41 are arranged in parallel on the detection card plate 4. Each card holder 41 is movably connected to the detection card plate 4. Eight microswitches 42 corresponding to the card holders 41 one by one are arranged on the card holders 41 for detecting whether the reagent cards are inserted. A detection displacement assembly 6 for moving the fluorescence detection head 2 is arranged in the housing 1. A sensor 3 for positioning the position of the reagent card is arranged on the detection displacement assembly 6. An identification probe 7 for scanning the encoding of the reagent card and a detection controller 8 for receiving and analyzing data are arranged in the housing 1. The identification probe 7, the fluorescence detection head 2, the sensor 3, the microswitches 42, the card plate displacement assembly 5 and the detection displacement assembly 6 are all electrically connected to the detection controller 8.

[0033] A detection frame for inserting the detection card plate 4 is provided on the side wall of the housing 1. A card plate push groove 11 adapted to the detection frame is fixedly connected to the side of the detection card. The card plate push groove 11 is slidably connected in the detection frame. Eight channel bayonets 12 corresponding to the card holders 41 are provided on the card plate push groove 11.

[0034] The identification probe 7 identifies the encoding of the reagent card, and then controls the card plate displacement assembly 5 through the detection controller 8 to move the detection card plate 4 out of the housing 1, sequentially push the reagent cards with the entered encoding into the card holders 41, and sense whether the reagent cards are fully inserted through the microswitches 42. After being fully inserted, the reagent cards are transferred to a proper position through the card plate displacement assembly 5, and then the detection displacement assembly 6 is controlled by the detection controller 8 to move the sensor 3 and the fluorescence detection head 2 to detect the reaction results. The detection results are batch-entered into the detection controller 8, improving the detection efficiency and the data analysis accuracy.

[0035] An elastic sheet 43 for fixing the reagent card is fixedly connected to each microswitch 42, and the elastic sheet 43 is movably connected to the reagent card. When the reagent card is inserted into the card holder 41 and contacts the microswitch 42, the elastic sheet 43 clamps and fixes the reagent card above the reagent card, improving the stability of the reagent card during movement and ensuring accurate test results.

[0036] A bottom heating plate 9 is fixedly connected to the bottom of the test card board 4, and an arched heating plate 10 is arranged on one side of the shell 1 close to the detection frame. The test card board 4 is movably connected below the arched heating plate 10. By means of the arched heating plate 10 and the bottom heating plate 9, the reaction speed of the reagent card can be increased, the reaction time can be shortened, and thus the detection efficiency can be improved.

[0037] The card board displacement assembly 5 includes a first motor 51, a card board transmission belt 52 and a card board fixing clamp 53. The first motor 51 is fixedly arranged in the shell 1. The card board fixing clamp 53 is fixedly connected to the test card board 4. The first motor 51 drives the card board transmission belt 52 to rotate, and the card board fixing clamp 53 is clamped on the card board transmission belt 52. The first motor 51 is electrically connected to the detection controller 8.

[0038] A card board displacement slider 14 is fixedly connected to the bottom of the test card board 4, and a card board displacement chute 13 which is matched with the card board displacement slider 14 to keep the movement of the test card board 4 stable is fixedly connected in the shell 1. The card board displacement slider 14 is slidably connected to the card board displacement chute 13.

[0039] Through the above technical solution, the detection controller 8 controls the first motor 51 to start. The first motor 51 drives the card board transmission belt 52 to rotate, and then drives the card board fixing clamp 53 clamped on the card board transmission belt 52 to move. The card board fixing clamp 53 is fixed to the test card board 4, so as to achieve the effect of driving the test card board 4 to move. During the movement of the test card board 4, the card board displacement slider 14 at the bottom of the test card board 4 slides on the card board displacement chute 13, ensuring the stability of the test card board 4 during movement, and thus improving the accuracy of the final test result.

[0040] The detection displacement assembly 6 includes a second motor 61, a detection transmission belt 62 and a detection fixing clamp 63. The second motor 61 is fixedly connected in the shell 1. The second motor 61 drives the detection transmission belt 62 to rotate. The detection fixing clamp 63 is clamped on the detection transmission belt 62. A connecting plate 17 is fixedly connected to the detection fixing clamp 63. The fluorescence detection head 2 and the sensor 3 are both fixedly connected below the connecting plate 17 and on one side close to the test card board 4. The second motor 61 is electrically connected to the detection controller 8.

[0041] Inside the housing 1, a detection displacement chute 15 is provided. Both sides of the detection displacement chute 15 are fixedly connected to the inside of the housing 1 through fixing brackets. A detection displacement slider 16 is slidably connected to the detection displacement chute 15. The fluorescence detection head 2 and the sensor 3 are both fixedly connected to the detection displacement slider 16.

[0042] Through the above technical solution, after the detection card plate 4 drives the reagent card to the detection position, the detection controller 8 controls the second motor 61 to drive the detection drive belt 62 to rotate, driving the detection fixed clamp 63 and the connecting plate 17 to move along with the detection drive belt 62, thereby driving the fluorescence detection head 2 and the sensor 3 to perform a moving detection. The sensor 3 senses and locates the position of the reagent card, and the fluorescence detection head 2 identifies and detects the reaction result area on the reagent card, and uploads the detection result to the detection controller 8. The detection controller 8 then records and analyzes the detection results batch by batch.

[0043] During use, the recognition probe 7 sequentially recognizes the codes on the reagent card. The detection controller 8 controls the first motor 51 to drive the card drive belt 52 to move the detection card plate 4 out of the housing 1, and the reagent cards with recorded codes are sequentially pushed into the corresponding card holders 41 through the 8 channel notches 12 of the card pushing groove 11. When the reagent card is pushed into the corresponding card holder 41, the reagent card touches the microswitch 42, and the reaction of the microswitch 42 makes the reagent card inserted into the correct position of the card holder 41, ensuring that the fluorescence detection head 2 can completely detect all the reaction results of the reagent card. After all the reagent cards are inserted into the card holders 41, the detection controller 8 controls the first motor 51 to drive the card drive belt 52 to drive the card displacement slider 14 of the detection card plate 4 to slide on the card displacement chute 13. After the detection card plate 4 enters the housing 1, it stays briefly at the arched heating plate 10 and the bottom heating plate 9. The arched heating plate 10 and the bottom heating plate 9 can increase the reaction speed of the reagent card and shorten the reaction time. Subsequently, the detection card plate 4 is driven to move until all the reagent cards reach the position where the fluorescence detection head 2 can completely detect. The second motor 61 is started to drive the detection drive belt 62 to drive the fluorescence detection head 2 and the sensor 3 connected through the detection fixed clamp 63 to move. The sensor 3 senses and locates the position of each reagent card, and then the fluorescence detection head 2 detects the reaction results on the reagent card and uploads the detection results to the detection controller 8. The detection controller 8 records the detection data batch by batch, improving the detection efficiency and the data analysis accuracy. After the detection is completed, the fluorescence detection head 2 returns to its original position for the next detection. The detection card plate 4 is moved out, and the staff replaces the reagent cards of the next batch for detection. Repeating the above operations can batch-detect the reagent cards, thereby improving the detection efficiency.

[0044] For those skilled in the art, it is obvious that the present utility model is not limited to the details of the above-mentioned exemplary embodiments, and the present utility model can be implemented in other specific forms without departing from the spirit or basic characteristics of the present utility model. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present utility model is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be embraced within the present utility model. Any reference signs in the claims should not be construed as limiting the claims involved.

[0045] In addition, it should be understood that although this specification is described according to embodiments, not every embodiment only contains an independent technical solution. This narrative manner of the specification is only for clarity. Those skilled in the art should regard the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. An 8-channel dry fluorescence analyzer, comprising a housing (1) and a fluorescence detection head (2) for detecting a reagent card, wherein the fluorescence detection head (2) is movably disposed in the housing (1), and is characterized in that: A detection card board (4) is arranged in the housing (1), a card board displacement assembly (5) for moving the detection card board (4) is movably arranged in the housing (1), the detection card board (4) is connected to the card board displacement assembly (5), eight card trays (41) are arranged in parallel on the detection card board (4), each of the card trays (41) is movably connected to the detection card board (4), and eight micro switches (42) corresponding to the card trays (41) for detecting whether a reagent card is inserted are arranged on the detection card tray (41), and the detection card tray (41) is provided with a plurality of micro switches (42) corresponding to the card trays (41) in a one-to-one manner. A detection displacement assembly (6) for moving a fluorescent detection head (2) is arranged in the housing (1); a sensor (3) for locating a reagent card is arranged on the detection displacement assembly (6); an identification probe (7) for scanning a reagent card code and a detection controller (8) for receiving and analyzing data are arranged in the housing (1); the identification probe (7), the fluorescent detection head (2), the sensor (3), the micro switch (42), the card plate displacement assembly (5) and the detection displacement assembly (6) are all electrically connected to the detection controller (8).

2. The 8-channel dry fluorescence analyzer according to claim 1, characterized in that: Each of the micro switches (42) is fixedly connected with an elastic sheet (43) for fixing a reagent card, and the elastic sheet (43) is movably connected to the reagent card.

3. The 8-channel dry fluorescence analyzer according to claim 1, characterized in that: The side wall of the housing (1) is provided with a detection frame for detecting the insertion of a card board (4); a card board push groove (11) adapted to the detection frame is fixedly connected to the side of the detection card; the card board push groove (11) is slidably connected in the detection frame; and the card board push groove (11) is provided with 8 channel bayonet holes (12) corresponding to the card tray (41).

4. The 8-channel dry fluorescence analyzer according to claim 1, characterized in that: A bottom heating plate (9) is fixedly connected to the bottom of the detection card plate (4); an arched heating plate (10) is arranged in the shell (1) on one side close to the detection frame; and the detection card plate (4) is movably connected to the bottom of the arched heating plate (10).

5. The 8-channel dry fluorescence analyzer according to claim 1, characterized in that: The cardboard displacement assembly (5) comprises a first motor (51), a cardboard transmission belt (52) and a cardboard fixing clamp (53); the first motor (51) is fixedly arranged in the housing (1); the cardboard fixing clamp (53) is fixedly connected to the detection cardboard (4); the first motor (51) drives the cardboard transmission belt (52) to rotate; the cardboard fixing clamp (53) is clamped on the cardboard transmission belt (52); and the first motor (51) is electrically connected to the detection controller (8).

6. The 8-channel dry fluorescence analyzer according to claim 1, characterized in that: A cardboard displacement slider (14) is fixedly connected to the bottom of the detection cardboard (4), and a cardboard displacement slide groove (13) is fixedly connected inside the housing (1) and cooperates with the cardboard displacement slider (14) to maintain the stable movement of the detection cardboard (4), and the cardboard displacement slider (14) is slidably connected to the cardboard displacement slide groove (13).

7. The 8-channel dry fluorescence analyzer according to claim 1, characterized in that: The detection displacement assembly (6) comprises a second motor (61), a detection transmission belt (62) and a detection fixed clamp (63); the second motor (61) is fixedly connected to the housing (1); the second motor (61) drives the detection transmission belt (62) to rotate; the detection fixed clamp (63) is clamped on the detection transmission belt (62); a connecting plate (17) is fixedly connected to the detection fixed clamp (63); the fluorescent detection head (2) and the sensor (3) are fixedly connected below the connecting plate (17) and close to a side of the detection card plate (4); and the second motor (61) is electrically connected to a detection controller (8).

8. The 8-channel dry fluorescence analyzer according to claim 1, characterized in that: A detection displacement slide groove (15) is provided in the housing (1), and two sides of the detection displacement slide groove (15) are fixedly connected to the housing (1) via a fixing frame. A detection displacement slider (16) is slidably connected to the detection displacement slide groove (15), and the fluorescent detection head (2) and the sensor (3) are both fixedly connected to the detection displacement slider (16).

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