Perfusion device and sample analyzer

Abstract

The utility model discloses a perfusion device and a sample analyzer. The filling device comprises a liquid path mechanism and a waste liquid mechanism, the liquid path mechanism comprises a first pipeline, a detection element, a second pipeline, a switching assembly and a driving assembly, one end of the first pipeline is communicated with the reagent bottle, the other end of the first pipeline is communicated with the switching assembly, and the detection element is arranged on the first pipeline and used for detecting gas in the first pipeline; one end of the second pipeline communicates with the switching assembly, the other end of the second pipeline communicates with the detection pool, the detection element is in communication connection with the switching assembly, the switching assembly communicates with the waste liquid mechanism and is used for communicating the first pipeline with the second pipeline or the waste liquid mechanism, and the waste liquid mechanism is used for discharging liquid in the first pipeline; the liquid volume driven by the driving assembly in a single period is smaller than the volume of the part of the first pipeline between the switching assembly and the detection element. The technical problem that reagents are wasted in the replacement process of an existing reagent bottle is solved.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, in particular to a perfusion device and a sample analyzer. Background Art

[0002] When the analyzer detects a sample, one or more reagents are used and quantitatively perfused into the detection cell each time through a perfusion device. When the detection element detects that the reagent is almost used up and gives an alarm, it is necessary to replenish the reagent in the reagent pipeline in time with a newly opened reagent bottle. During the process of replacing the reagent bottle, it is necessary to discharge the air bubbles inhaled in the pipeline and refill the entire reagent pipeline system with the newly opened reagent bottle. The process of discharging air bubbles is to run for several cycles after replacing the new reagent bottle and then connect it to the detection cell, resulting in a large amount of reagent waste. Summary of the Utility Model

[0003] In view of this, the utility model provides a perfusion device and a sample analyzer to solve the technical problem of reagent waste during the replacement of the existing reagent bottle.

[0004] To solve the above technical problem, the first technical solution adopted by the utility model is as follows:

[0005] A perfusion device, the perfusion device includes a liquid path mechanism and a waste liquid mechanism. The liquid path mechanism includes a first pipeline, a detection element, a second pipeline, a switching component and a driving component. One end of the first pipeline is connected to a reagent bottle, and the other end is connected to the switching component. The detection element is arranged on the first pipeline and is used to detect the gas in the first pipeline. One end of the second pipeline is connected to the switching component, and the other end is connected to a detection cell. The detection element is communicatively connected to the switching component. The switching component is connected to the waste liquid mechanism. The switching component is used to connect the first pipeline to the second pipeline or the waste liquid mechanism. The waste liquid mechanism is used to discharge the liquid in the first pipeline. The driving component is used to periodically drive the liquid in the second pipeline to flow, and the volume of the liquid driven by the driving component in a single cycle is less than the volume of a partial section of the first pipeline between the switching component and the detection element.

[0006] In some embodiments of the perfusion device, the switching component includes a first switching piece, the first switching piece has a first port, a second port and a third port. The first port can be connected to the second port or the third port. The first port is connected to the first pipeline, the second port is connected to the second pipeline, and the third port is connected to the waste liquid mechanism.

[0007] In some embodiments of the perfusion device, the waste liquid mechanism includes a third pipeline and a waste liquid component. The waste liquid component is communicated with the switching component through the third pipeline and can form a negative pressure. The switching component includes a three-way joint and a switching element. The three-way joint is respectively communicated with the first pipeline, the second pipeline and the third pipeline. The switching element is used to control the on-off of the third pipeline.

[0008] In some embodiments of the perfusion device, the second pipeline includes a first branch and a second branch. One end of the first branch is communicated with the switching component, and the other end is communicated with the driving component. One end of the second branch is communicated with the driving component, and the other end is communicated with the detection cell. The driving component is used to make the liquid in the first branch enter the second branch and flow in the second branch.

[0009] In some embodiments of the perfusion device, the driving component includes a second switching element and a suction and discharge element. The second switching element has a fourth port, a fifth port and a sixth port. The fourth port can be communicated with the fifth port or the sixth port. The fourth port is communicated with the output end of the suction and discharge element. The fifth port is communicated with the first branch, and the sixth port is communicated with the second branch.

[0010] In some embodiments of the perfusion device, the perfusion device further includes a heating mechanism. The heating mechanism is located between the driving component and the detection cell and is used to heat the liquid in the second pipeline between the driving component and the detection cell.

[0011] In some embodiments of the perfusion device, the waste liquid component includes a waste liquid tank and a negative pressure element. The negative pressure element is communicated with the waste liquid tank so that the waste liquid tank can extract the waste liquid in the first pipeline.

[0012] In some embodiments of the perfusion device, the waste liquid component further includes a fourth pipeline. One end of the fourth pipeline is communicated with the waste liquid tank, and the other end extends out of the machine. The negative pressure element is communicated with the waste liquid tank through the fourth pipeline to be able to discharge the waste liquid in the first pipeline out of the machine.

[0013] In some embodiments of the perfusion device, the number of the liquid path components is multiple. Each liquid path component is arranged in parallel and is communicated with the detection cell and the waste liquid mechanism.

[0014] To solve the above technical problems, the second technical solution adopted by the present utility model is:

[0015] A sample analyzer includes a sampling device, a detection device, and the perfusion device described in the above embodiments. The sampling device is used to add a sample into a detection cell to mix with a reagent in the detection cell to form a liquid to be tested, and the detection device is used to detect the liquid to be tested.

[0016] Implementing the embodiments of the present invention will at least have the following beneficial effects:

[0017] When the above perfusion device is applied to a sample analyzer, it can enable itself and the sample analyzer to have the technical effect of avoiding wasting reagents when replacing a reagent bottle. Specifically, the detection element of the present invention is communicatively connected to the switching component. When the detection element detects that there is gas in the first pipeline, it indicates that there is no liquid left in the reagent bottle and needs to be replaced. At this time, it is transmitted to the switching component, and the switching component can switch from the communication state between the first pipeline and the second pipeline to the communication state between the first pipeline and the waste liquid mechanism. And since the volume of liquid driven by the driving component in a single cycle is less than the volume of a partial section of the first pipeline between the switching component and the detection element, the second pipeline is still filled with liquid and there is no gas. In this way, the waste liquid consumed when replacing the reagent bottle is only slightly more than the pipeline solvent of the first pipeline, greatly reducing the loss of reagents, and the time for replacing the reagent bottle is short, solving the technical problem of reagent waste existing in the process of replacing existing reagent bottles. Description of the Drawings

[0018] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0019] Figure 1 It is a schematic diagram of a simple structure of a perfusion device with multiple liquid path mechanisms in an embodiment;

[0020] Figure 2 It is a schematic diagram of a simple structure of a perfusion device with a single liquid path mechanism in an embodiment;

[0021] Figure 3 It is a schematic diagram of a simple structure of a perfusion device with a single liquid path mechanism in an embodiment.

[0022] Wherein:

[0023] 1. Liquid path mechanism; 11. First pipeline; 12. Detection element; 13. Second pipeline; 131. First branch; 132. Second branch; 14. Switching component; 141. First switching part; 1411. First port; 1412. Second port; 1413. Third port; 142. Three-way joint; 143. On-off part; 15. Driving component; 151. Second switching part; 1511. Fourth port; 1512. Fifth port; 1513. Sixth port; 152. Suction and discharge part

[0024] 2. Waste liquid mechanism; 21. Third pipeline; 22. Waste liquid component; 221. Waste liquid tank; 222. Negative pressure part; 223. Fourth pipeline

[0025] 3. Reagent bottle; 4. Detection cell; 5. Heating mechanism Detailed implementation manners

[0026] To facilitate the understanding of the present utility model, the present utility model will be described more comprehensively below with reference to the relevant drawings. The preferred embodiments of the present utility model are shown in the drawings. However, the present utility model can be implemented in many other different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure content of the present utility model more thorough and comprehensive

[0027] It should be noted that when an element is referred to as being "fixed to" another element, it can be directly on the other element or there may also be an intermediate element. When an element is considered to be "connected" to another element, it can be directly connected to the other element or there may be an intermediate element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are only for the purpose of illustration

[0028] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the technical field to which the present utility model belongs. The terms used in the specification of the present utility model herein are only for the purpose of describing specific embodiments and are not intended to limit the present utility model. The term "and / or" used herein includes any and all combinations of one or more of the related listed items

[0029] Such as Figures 1 - 3As shown, in an embodiment of a perfusion device, the perfusion device includes a liquid path mechanism 1 and a waste liquid mechanism 2. The liquid path mechanism 1 includes a first pipeline 11, a detection element 12, a second pipeline 13, a switching component 14, and a driving component 15. One end of the first pipeline 11 is connected to a reagent bottle 3, and the other end is connected to the switching component 14. The detection element 12 is disposed in the first pipeline 11 and is used to detect the gas in the first pipeline 11. One end of the second pipeline 13 is connected to the switching component 14, and the other end is connected to a detection cell 4. The detection element 12 is communicatively connected to the switching component 14. The switching component 14 is connected to the waste liquid mechanism 2. The switching component 14 is used to connect the first pipeline 11 to the second pipeline 13 or the waste liquid mechanism 2. The waste liquid mechanism 2 is used to discharge the liquid in the first pipeline 11. The driving component 15 is used to periodically drive the liquid in the second pipeline 13 to flow. The volume of the liquid driven by the driving component 15 in a single cycle is less than the volume of a partial section of the first pipeline 11 between the switching component 14 and the detection element 12.

[0030] In this embodiment, the detection element 12 is communicatively connected to the switching component 14. When the detection element 12 detects that there is gas in the first pipeline 11, it indicates that there is no liquid left in the reagent bottle 3 and needs to be replaced. At this time, it is transmitted to the switching component 14. The switching component 14 can switch from the connected state of the first pipeline 11 and the second pipeline 13 to the connected state of the first pipeline 11 and the waste liquid mechanism 2. And because the volume of the liquid driven by the driving component 15 in a single cycle is less than the volume of a partial section of the first pipeline 11 between the switching component 14 and the detection element 12, the second pipeline 13 is still filled with liquid and there is no gas. In this way, the waste liquid consumed for replacing the reagent bottle 3 is only slightly more than the pipeline solvent of the first pipeline 11, greatly reducing the loss of the reagent, and the time for replacing the reagent bottle 3 is short, solving the technical problem of reagent waste existing in the process of replacing the existing reagent bottle 3.

[0031] Specifically, the detection element 12 can be an optocoupler. The detection light emitted by the optocoupler can pass through the first pipeline 11 or the optocoupler is made into a tubular structural member. When the optocoupler detects, signals of different intensities are detected. Therefore, when the signal detected by the optocoupler is stronger than a certain threshold, it is determined that there is liquid in the first pipeline 11. When the signal detected by the optocoupler is lower than a certain threshold, it is determined that there is no liquid or there is gas in the first pipeline 11, and at the same time, an alarm of no reagent signal is output.

[0032] In an embodiment of a perfusion device, the switching component 14 includes a first switching member 141. The first switching member 141 has a first port 1411, a second port 1412, and a third port 1413. The first port 1411 can be connected to the second port 1412 or the third port 1413. The first port 1411 is connected to the first pipeline 11. The second port 1412 is connected to the second pipeline 13. The third port 1413 is connected to the waste liquid mechanism 2.

[0033] In this embodiment, the first switching member 141 is a one-in-two-out three-way type, which can be a solenoid valve, and can be conveniently configured to form a communication connection with the detection element 12 in cooperation with the control system. When the detection element 12 sends a signal, the first switching member 141 can quickly switch to a state where the first pipeline 11 is connected to the waste liquid mechanism 2, so as to prevent the gas in the first pipeline 11 from entering the second pipeline 13.

[0034] In an embodiment of a perfusion device, the waste liquid mechanism 2 includes a third pipeline 21 and a waste liquid assembly 22. The waste liquid assembly 22 is connected to the switching assembly 14 through the third pipeline 21 and can form a negative pressure. The switching assembly 14 includes a three-way joint 142 and a switching member 143. The three-way joint 142 is respectively connected to the first pipeline 11, the second pipeline 13 and the third pipeline 21, and the switching member 143 is used to control the on / off of the third pipeline 21.

[0035] Different from the previous embodiment, the switching assembly 14 in this embodiment is different from the previous embodiment. In this embodiment, a three-way solenoid valve is not used, but a combination of a three-way joint 142 and a switching member 143 is adopted. The switching member 143 can be a simple solenoid valve that controls the on / off of a single pipeline. At this time, the detection element 12 is communicatively connected to the switching member 143. When the detection element 12 detects that there is no liquid or there is gas in the first pipeline 11, the switching member 143 releases the blockage of the third pipeline 21, and the negative pressure of the waste liquid assembly 22 extracts the liquid in the first pipeline 11 through the third pipeline 21 and the three-way joint 142.

[0036] Preferably, the connecting pipeline between the three-way joint 142 and the switching member needs to be set shorter to improve the effect of negative pressure and prevent the liquid in the first pipeline 11 from entering the second pipeline 13 through the three-way joint 142.

[0037] Specifically, the waste liquid assembly 22 includes a waste liquid tank 221 and a negative pressure member 222. The negative pressure member 222 is connected to the waste liquid tank 221 so that the waste liquid tank 221 can extract the waste liquid in the first pipeline 11. The negative pressure member 222 can be a vacuum pump. Further preferably, the waste liquid assembly 22 further includes a fourth pipeline 223. One end of the fourth pipeline 223 is connected to the waste liquid tank 221, and the other end extends outside the machine. The negative pressure member 222 is connected to the waste liquid tank 221 through the fourth pipeline 223 to be able to discharge the waste liquid in the first pipeline 11 outside the machine. Discharging the waste liquid outside the machine through the fourth pipeline 223 can reduce the accumulation of waste liquid in the instrument.

[0038] In an embodiment of the perfusion device, the second pipeline 13 includes a first branch 131 and a second branch 132. One end of the first branch 131 communicates with the switching component 14, and the other end communicates with the driving component 15. One end of the second branch 132 communicates with the driving component 15, and the other end communicates with the detection cell 4. The driving component 15 is configured to allow the liquid in the first branch 131 to enter the second branch 132 and flow therein.

[0039] In this embodiment, the driving component 15 functions to drive the liquid flow. By dividing the second pipeline 13 into the first branch 131 and the second branch 132, it is convenient to delimit the cycle of the driving component 15. It receives the liquid from the first branch 131 and then discharges it into the second branch 132. One reception and one discharge form a cycle, and it is easy to control the amount of liquid driven in one cycle.

[0040] In an embodiment of the perfusion device, the driving component 15 includes a second switching member 151 and a suction and discharge member 152. The second switching member 151 has a fourth port 1511, a fifth port 1512, and a sixth port 1513. The fourth port 1511 can communicate with the fifth port 1512 or the sixth port 1513. The fourth port 1511 communicates with the output end of the suction and discharge member 152. The fifth port 1512 communicates with the first branch 131, and the sixth port 1513 communicates with the second branch 132.

[0041] Combined with the previous embodiment, the driving component 15 in this embodiment has a suction and discharge member 152, which can be, for example, an injection-type structural member. The second switching member 151 can be a one-in-two-out three-way solenoid valve similar to the first switching member 141, and the communication method is different from that of the first switching member 141. The suction and discharge member 152 is connected to the fourth port 1511 of the second switching member 151 and can communicate with the fifth port 1512 and the sixth port 1513 respectively through switching. The liquid in the first branch 131 is discharged into the second branch 132 by a suction and discharge method. One suction and one discharge form a cycle, which further facilitates the control of the liquid amount in one cycle.

[0042] In addition, in other embodiments of the driving component 15, it can also be a peristaltic pump, and the amount of liquid driven by a single peristalsis is also within a controllable range.

[0043] In an embodiment of the perfusion device, the perfusion device further includes a heating mechanism 5. The heating mechanism 5 is located between the driving component 15 and the detection cell 4 and is configured to heat the liquid in the second pipeline 13 between the driving component 15 and the detection cell 4.

[0044] In this embodiment, by providing the heating mechanism 5, the liquid can be heated, thereby meeting the temperature requirements. Specifically, the heating mechanism 5 can be sleeved on the second branch 132.

[0045] In addition, in combination with the previous embodiments, it can be understood that the second pipeline 13 in the present utility model is not replaced, and the second pipeline 13 is always filled with liquid during the process of replacing the reagent bottle 3, and the heating mechanism 5 is also always heating the liquid in the second branch 132. Thus, after the reagent bottle 3 is replaced, it can be immediately used for detection without waiting, improving the replacement efficiency.

[0046] In addition, different detection items require different amounts of reagents. In an embodiment of the perfusion device, the number of liquid path mechanisms 1 is multiple, and each liquid path mechanism 1 is arranged in parallel and is connected to both the detection pool 4 and the waste liquid mechanism 2. By providing multiple liquid path mechanisms 1 and arranging them in parallel, various reagent liquids can be input into the same detection pool 4 in the same way. The more the number of liquid path mechanisms 1, the more obvious it is to perceive the amount of reagent that can be avoided from being wasted by this liquid path mechanism 1, and the significant reduction in replacement time, facilitating the use efficiency of medical staff.

[0047] The present utility model also relates to a sample analyzer, including a sample adding device, a detection device, and the perfusion device in the previous embodiments. The sample adding device is used to add a sample into the detection pool 4 to form a test solution by mixing with the reagent in the detection pool 4, and the detection device is used to detect the test solution.

[0048] The perfusion device cooperates with the sample adding device to form a test solution, and then obtains a detection result under the detection of the detection device. By adopting the perfusion device in the above embodiments, the sample analyzer using it can have the technical effect of reducing reagent waste during the process of replacing the reagent bottle 3, thereby improving the replacement efficiency and facilitating the use of medical staff.

[0049] The technical features of the above embodiments can be combined arbitrarily. For the sake of concise description, not all possible combinations of the technical features in the above embodiments are described. However, as long as these technical feature combinations do not conflict, they should be considered as within the scope described in this specification.

[0050] The above embodiments only represent several implementation manners of the present utility model, and their descriptions are relatively specific and detailed, but they should not be construed as limiting the scope of the patent application. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present utility model, several modifications and improvements can still be made, and these all belong to the protection scope of the present utility model. Therefore, the protection scope of the patent of the present utility model should be subject to the appended claims.

Claims

1. A perfusion device, characterized in that: The perfusion device includes a liquid circuit mechanism and a waste liquid mechanism, and the liquid circuit mechanism includes a first pipeline, a detection element, a second pipeline, a switching component and a driving component. One end of the first pipeline is connected to the reagent bottle, and the other end is connected to the switching component. The detection element is arranged in the first pipeline and is used to detect the gas in the first pipeline. One end of the second pipeline is connected to the switching component, and the other end is connected to the detection tank. The detection element is communicatively connected with the switching component, and the switching component is connected with the waste liquid mechanism. The switching component is used to connect the first pipeline with the second pipeline or the waste liquid mechanism, and the waste liquid mechanism is used to discharge the liquid in the first pipeline; the driving component is used to periodically drive the liquid flow in the second pipeline, and the volume of liquid driven by the driving component in a single cycle is smaller than the volume of the first pipeline in the partial section between the switching component and the detection element.

2. The perfusion device according to claim 1, characterized in that The switching assembly includes a first switching member, which has a first port, a second port and a third port. The first port can be connected to the second port or the third port. The first port is connected to the first pipeline, the second port is connected to the second pipeline, and the third port is connected to the waste liquid mechanism.

3. The perfusion device according to claim 1, characterized in that The waste liquid mechanism includes a third pipeline and a waste liquid component. The waste liquid component is connected to the switching component through the third pipeline and can form a negative pressure. The switching component includes a three-way connector and a switch. The three-way connector is respectively connected to the first pipeline, the second pipeline and the third pipeline, and the switch is used to control the opening and closing of the third pipeline.

4. The perfusion device according to claim 1, characterized in that The second pipeline includes a first branch and a second branch. One end of the first branch is connected to the switching component, and the other end is connected to the driving component. One end of the second branch is connected to the driving component, and the other end is connected to the detection tank. The driving component is used to allow the liquid in the first branch to enter the second branch and flow in the second branch.

5. The perfusion device according to claim 4, characterized in that The driving assembly includes a second switching member and a suction and discharge member, the second switching member has a fourth port, a fifth port and a sixth port, the fourth port can be connected to the fifth port or the sixth port, the fourth port is connected to the output end of the suction and discharge member, the fifth port is connected to the first branch, and the sixth port is connected to the second branch.

6. The perfusion device according to claim 1, characterized in that The perfusion device further comprises a heating mechanism, which is located between the driving assembly and the detection tank and is used to heat the liquid in the second pipeline between the driving assembly and the detection tank.

7. The perfusion device according to claim 3, characterized in that The waste liquid assembly includes a waste liquid tank and a negative pressure piece, and the negative pressure piece is communicated with the waste liquid tank so that the waste liquid tank can extract the waste liquid in the first pipeline.

8. The perfusion device according to claim 7, characterized in that The waste liquid component also includes a fourth pipeline, one end of which is connected to the waste liquid tank and the other end extends out of the machine. The negative pressure member is connected to the waste liquid tank through the fourth pipeline so that the waste liquid in the first pipeline can be discharged out of the machine.

9. The perfusion device according to any one of claims 1 to 8, characterized in that: There are multiple liquid path mechanisms, each of which is arranged in parallel and is connected to the detection pool and the waste liquid mechanism.

10. A sample analyzer, characterized in that: It comprises a sample adding device, a detection device and a perfusion device as described in any one of claims 1 to 9, wherein the sample adding device is used to add a sample into a detection pool to mix with a reagent in the detection pool to form a test liquid, and the detection device is used to detect the test liquid.

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