POCT full-automatic chemiluminescence equipment

Abstract

The utility model belongs to the field of medical equipment, and provides POCT (Point of Care Testing) full-automatic chemiluminescence equipment which comprises a mounting frame; the reaction bin assembly is arranged on the mounting frame, can reciprocate in the length direction of the mounting frame, and is used for loading reagent strips; the PMT assembly is arranged at the rear end of the mounting frame and located above the reaction bin assembly, the reaction bin assembly is used for moving the reagent strip to the PMT assembly, and the PMT assembly is used for conducting luminous value detection on the detection position of the reagent strip; the multi-channel parallel pretreatment device is arranged on the mounting frame, is positioned in front of the PMT device, is positioned above the reaction bin assembly, can reciprocate along the length direction of the mounting frame, and is used for sucking and spitting samples from the reagent strips and transferring magnetic particles. The multi-channel parallel pretreatment device disclosed by the utility model is movably arranged in the mounting frame and can move relative to the reaction bin assembly, so that the pretreatment speed of the multi-channel parallel pretreatment device is accelerated.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical equipment, and particularly relates to a POCT fully automatic chemiluminescence device. Background Art

[0002] As a rapidly developing non-radioactive immunoassay technology, chemiluminescence immunoassay technology has become one of the important directions in immunological detection. Its principle is to directly measure the immune reaction using chemiluminescence signals. Chemiluminescence devices applying chemiluminescence immunoassay technology have advantages such as high sensitivity, good repeatability, high accuracy, good specificity, and a wide linear range.

[0003] POCT (Point-Of-Care Testing) is a detection method that immediately conducts clinical tests at the sampling site, eliminating the complex processing procedures of specimens in the laboratory, and thus quickly obtaining test results. It has the characteristics of simple instrument preparation, easy operation, and rapid reporting of results.

[0004] Currently, by applying chemiluminescence immunoassay technology to POCT products, POCT fully automatic chemiluminescence devices have been manufactured. Such devices have the advantages of immediate detection and rapid obtaining of diagnostic results, and have been rapidly and widely promoted in the in vitro diagnosis industry. However, with the increasing requirement for detection speed, how to further improve the detection speed of POCT fully automatic chemiluminescence devices has become a problem that many manufacturers are committed to solving.

[0005] In addition, a POCT fully automatic chemiluminescence device generally includes a reaction chamber module and a pretreatment module. The reaction chamber module is used to load reagent strips sealed with various reagents, and it moves the reagent strips to the pretreatment module for corresponding processing. The length of the reagent strip is affected by the number of detection items. When the number of detection items increases, the reagents sealed in the reagent strip also need to be increased correspondingly, and then the length of the reagent strip will increase.

[0006] When the device is used for the detection and analysis of multiple items, the distance that the reaction chamber module needs to move with the reagent strip in the device will increase, so as to move the reagent strip to the pretreatment module to perform corresponding processing on each hole position. However, this will cause the device volume to increase, which is not conducive to the miniaturization and portability of the device, and will also prolong the time for detection and obtaining diagnostic results. Summary of the Utility Model

[0007] The embodiment of the utility model provides a POCT fully automatic chemiluminescence device, aiming to solve the technical problems of how to further improve the detection speed of the POCT fully automatic chemiluminescence device, and how to control the device volume and ensure the detection speed when increasing the reagent strip to meet the detection requirements of multiple items.

[0008] The embodiments of the present utility model are implemented as follows. A POCT fully automatic chemiluminescence device includes:

[0009] An installation frame;

[0010] A reaction chamber assembly disposed on the installation frame, the reaction chamber assembly being reciprocally movable along the length direction of the installation frame, and the reaction chamber assembly being used for loading reagent strips;

[0011] A PMT assembly disposed at the rear end of the installation frame and above the reaction chamber assembly, the reaction chamber assembly being used for moving the reagent strip to the PMT assembly, and the PMT assembly being used for detecting the luminescence value of the detection position of the reagent strip; and

[0012] A multi-channel parallel preprocessing device disposed on the installation frame and in front of the PMT assembly, the multi-channel parallel preprocessing device being located above the reaction chamber assembly and being reciprocally movable along the length direction of the installation frame, and the multi-channel parallel preprocessing device being used for aspirating and discharging samples and transferring magnetic microparticles on the reagent strip.

[0013] Furthermore, a first driving element and a first guide rail are provided on the bottom plate of the installation frame, the first driving element is located at the rear end of the installation frame, the first guide rail extends along the length direction of the installation frame, the multi-channel parallel preprocessing device is in transmission connection with the first driving element and is movably arranged on the first guide rail.

[0014] Furthermore, the multi-channel parallel preprocessing device includes:

[0015] A gantry disposed on the bottom plate of the installation frame, the gantry being movably arranged on the first guide rail and in transmission connection with the first driving element, and a second driving element is provided at the top of the gantry;

[0016] A sample extraction mechanism disposed on the gantry, the sample extraction mechanism being in transmission connection with the second driving element and being able to lift and lower under the drive of the second driving element to aspirate and discharge the sample on the reagent strip; and

[0017] A sample preprocessing mechanism disposed on the gantry, the sample preprocessing mechanism being in transmission connection with the second driving element and being able to lift and lower under the drive of the second driving element to transfer the magnetic microparticles on the reagent strip.

[0018] Further, a first driving pulley is provided on the transmission shaft of the first driving element, a first mounting seat is provided at the front end of the bottom plate of the mounting frame, a first driven pulley is provided on the first mounting seat, the first driving pulley is in transmission connection with the first driven pulley through a belt, and a first synchronous belt pressing plate connected to the belt is provided at the bottom of the gantry.

[0019] Further, the first driving element is a lead screw motor, and the transmission lead screw of the first driving element is in transmission connection with the bottom end of the gantry.

[0020] Further, the sample extraction mechanism includes:

[0021] A first mounting frame provided on the gantry and in transmission connection with the second driving element, and the second driving element can drive the first mounting frame to lift;

[0022] A third driving element provided on the first mounting frame; and

[0023] An extraction assembly provided on the first mounting frame and in transmission connection with the third driving element, and the third driving element can drive the extraction assembly to act in the vertical direction to aspirate and discharge samples.

[0024] Further, the extraction assembly includes:

[0025] An injection device provided on the first mounting frame, a syringe cavity is formed in the injection device, a first loading head for loading tip heads is provided at the bottom of the injection device, and the first loading head is communicated with the syringe cavity;

[0026] A first push plate provided above the injection device, and the first push plate is in transmission connection with the third driving element; and

[0027] A piston rod provided on the first push plate, the piston rod is movably and sealingly connected to the syringe cavity, and the third driving element can drive the first push plate to drive the piston rod to lift in the syringe cavity to perform aspiration and discharge actions.

[0028] Further, the sample extraction mechanism further includes:

[0029] A push rod that is liftably inserted through the injection device, and the top end of the push rod is spaced from the first push plate;

[0030] An elastic element sleeving the push rod located in the injection device, and the elastic element expands or contracts simultaneously when the push rod lifts relative to the injection device; and

[0031] A separation plate is arranged at the bottom of the injection device, the first loading head passes through the separation plate, the bottom end of the push rod is connected to the separation plate, and the push rod can drive the separation plate to rise and fall relative to the first loading head.

[0032] Furthermore, there are multiple syringe cavities, and the multiple syringe cavities are evenly distributed along the length direction of the injection device;

[0033] There are a plurality of first loading heads, and the plurality of first loading heads are evenly spaced and distributed along the length direction of the injection device;

[0034] There are multiple piston rods, and the multiple piston rods are evenly distributed along the length direction of the first push plate.

[0035] Furthermore, the sample pre-processing mechanism includes:

[0036] A second mounting frame provided on the gantry and drivingly connected to the second driving element, wherein the second driving element can drive the second mounting frame to rise and fall;

[0037] a fourth driving element disposed on the second mounting frame; and

[0038] A pre-processing component is arranged on the second mounting frame and is transmission-connected to the fourth driving element. The fourth driving element can drive the pre-processing component to move in a vertical direction to transfer magnetic particles.

[0039] Furthermore, the pre-processing component includes:

[0040] A magnetic bar device is arranged on the second mounting frame, wherein an active through hole is formed in the magnetic bar device, and a second loading head for loading a disposable magnetic separation sleeve is arranged at the bottom of the magnetic bar device, and the second loading head is communicated with the active through hole;

[0041] a second push plate disposed above the magnetic bar device, the second push plate being drivingly connected to the fourth driving element; and

[0042] A connecting rod is arranged on the second pushing plate, and a magnetic bar is arranged on the free end of the connecting rod. The fourth driving element can drive the second pushing plate to drive the magnetic bar to rise and fall in the corresponding movable through hole so as to be separated from the second loading head or pass through the second loading head.

[0043] Furthermore, the magnetic bars are arranged in multiple rows, and the magnetic bars in the multiple rows are evenly spaced and distributed on the second push plate along the width direction of the second push plate;

[0044] There are multiple magnetic bars in each row, and the multiple magnetic bars are evenly distributed on the second pushing plate along the length direction of the second pushing plate at intervals.

[0045] Further, the sample extraction mechanism is opposite to the sample pretreatment mechanism, and the sample extraction mechanism is located in front of the sample pretreatment mechanism. The second driving element, the third driving element, and the fourth driving element are linearly arranged on the top of the gantry.

[0046] Further, an activity space is provided on the gantry. The transmission shaft of the second driving element passes through the activity space, and a transmission plate is sleeved on the transmission shaft. When the transmission shaft moves, the transmission plate can lift in the activity space;

[0047] One side of the first mounting bracket facing the gantry is provided with a first connection portion, and one side of the second mounting bracket facing the gantry is provided with a second connection portion. Both the first connection portion and the second connection portion are connected to the transmission plate.

[0048] Further, the reaction chamber assembly includes:

[0049] A second guide rail provided on the bottom plate of the mounting frame;

[0050] A reaction chamber main body provided on the second guide rail. A slider slidably connected to the second guide rail is provided at the bottom of the reaction chamber main body. A plurality of uniformly spaced accommodation grooves for loading reagent strips are provided on the reaction chamber main body, and the accommodation grooves extend along the length direction of the reaction chamber main body;

[0051] A fifth driving element provided on the bottom plate of the mounting frame and located at the rear end of the second guide rail. A second driving pulley is provided on the transmission shaft of the fifth driving element;

[0052] A second mounting seat provided on the bottom plate of the mounting frame and located at the front end of the second guide rail. A second driven pulley is provided on the second mounting seat. The second driving pulley is connected to the second driven pulley through a belt; and

[0053] A second synchronous belt pressing plate provided on one side of the reaction chamber main body. The second synchronous belt pressing plate is connected to the belt.

[0054] Further, the PMT assembly includes:

[0055] A mounting bracket provided on the bottom plate of the mounting frame;

[0056] A third mounting bracket provided on the mounting bracket;

[0057] A fourth mounting bracket provided at the bottom of the third mounting bracket;

[0058] A PMT module provided on the fourth mounting bracket;

[0059] A sixth driving element provided on the top of the third mounting bracket and drivingly connected to the fourth mounting bracket, the sixth driving element being capable of driving the fourth mounting bracket to move up and down to drive the PMT module to move up and down;

[0060] A seventh driving element and a third driven pulley respectively provided on both sides of the top of the mounting bracket, a third driving pulley being provided on the transmission shaft of the seventh driving element, the third driving pulley being drivingly connected to the third driven pulley through a belt; and

[0061] A third synchronous belt pressing plate provided on the third mounting bracket, the third synchronous belt pressing plate being connected to the belt.

[0062] In the POCT fully automatic chemiluminescence device according to the embodiment of the present invention, by movably arranging the multi-channel parallel pre-treatment device in the mounting frame, the multi-channel parallel pre-treatment device can move relative to the reaction chamber assembly, thereby accelerating the speed at which the reagent strip moves to the multi-channel parallel pre-treatment device, and further accelerating the pre-treatment speed of the multi-channel parallel pre-treatment device for the reagent strip, so as to achieve the purpose of improving the analysis efficiency of the POCT fully automatic chemiluminescence device.

[0063] In addition, when the reagent strip is used for multiple detection items and the length of the reagent strip becomes longer, in order to enable the multi-channel parallel pre-treatment device to quickly pre-treat the reagent strip, the reaction chamber assembly does not need to move the reagent strip a long distance, but can shorten the moving distance between the multi-channel parallel pre-treatment device and the reagent strip through the relative movement of the multi-channel parallel pre-treatment device, which is convenient for the multi-channel parallel pre-treatment device to perform pre-treatment between the respective holes of the reagent strip, and can control the volume of the POCT fully automatic chemiluminescence device while realizing the efficient detection of multiple detection items. Description of the Drawings

[0064] Figure 1 is a three-dimensional schematic diagram of the POCT fully automatic chemiluminescence device according to the embodiment of the present invention;

[0065] Figure 2 is another three-dimensional schematic diagram of a part of the POCT fully automatic chemiluminescence device according to the embodiment of the present invention;

[0066] Figure 3 is another three-dimensional schematic diagram of a part of the POCT fully automatic chemiluminescence device according to the embodiment of the present invention;

[0067] Figure 4 is a three-dimensional schematic diagram of the mounting frame according to an embodiment of the present invention;

[0068] Figure 5 is another three-dimensional schematic diagram of the mounting frame according to an embodiment of the present invention;

[0069] Figure 6 is a three-dimensional schematic diagram of the multi-channel parallel preprocessing device according to an embodiment of the present utility model;

[0070] Figure 7 is another three-dimensional schematic diagram of the multi-channel parallel preprocessing device according to an embodiment of the present utility model;

[0071] Figure 8 is a structural schematic diagram of the multi-channel parallel preprocessing device according to an embodiment of the present utility model;

[0072] Figure 9 is a three-dimensional disassembly schematic diagram of the multi-channel parallel preprocessing device according to an embodiment of the present utility model;

[0073] Figure 10 is a three-dimensional schematic diagram of the gantry according to an embodiment of the present utility model;

[0074] Figure 11 is a three-dimensional schematic diagram of the sample extraction mechanism according to an embodiment of the present utility model;

[0075] Figure 12 is a three-dimensional schematic diagram of the sample preprocessing mechanism according to an embodiment of the present utility model;

[0076] Figure 13 is a three-dimensional schematic diagram of the PMT component according to an embodiment of the present utility model;

[0077] Figure 14 is a three-dimensional schematic diagram of the reaction chamber main body according to an embodiment of the present utility model;

[0078] Figure 15 is a sectional schematic diagram of the reagent strip according to an embodiment of the present utility model.

[0079] Description of main element symbols:

[0080] Installation frame - 10; First mounting seat - 11; First driven pulley - 111; Reaction chamber assembly - 20; Reaction chamber body - 21; Accommodation groove - 211; Reagent strip - 30; Handle - 31; Tip head - 32; Disposable magnetic separation sleeve - 33; PMT assembly - 40; Mounting bracket - 41; Third mounting frame - 42; Fourth mounting frame - 43; PMT module - 44; Sixth driving element - 45; Seventh driving element - 46; Third driven pulley - 47; Multichannel parallel pre - treatment device - 50; First driving element - 51; First driving pulley - 511; First guide rail - 52; Gantry - 53; Activity space - 531; Transmission plate - 532; Second driving element - 54; Sample extraction mechanism - 55; First mounting frame - 551; Third driving element - 552; Extraction assembly - 553; Injection device - 5531; First loading head - 5532; First push plate - 5533; Piston rod - 5534; Push rod - 5535; Elastic element - 5536; Separation plate - 5537; Sample pre - treatment mechanism - 56; Second mounting frame - 561; Fourth driving element - 562; Pre - treatment assembly - 563; Magnetic rod device - 5631; Second loading head - 5632; Second push plate - 5633; Connecting rod - 5634; Magnetic rod - 5635; POCT fully automatic chemiluminescence device - 100. Detailed implementation mode

[0081] In order to make the objectives, technical solutions and advantages of the present utility model clearer and more understandable, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments. The examples of the embodiments are shown in the accompanying drawings, where the same or similar reference numerals represent the same or similar elements or elements with the same or similar functions from beginning to end. The embodiments described below by referring to the accompanying drawings are exemplary and are only used to explain the present utility model and should not be construed as a limitation to the present utility model. In addition, it should be understood that the specific embodiments described herein are only used to explain the present utility model and are not used to limit the present utility model.

[0082] In the description of the present utility model, it should be understood that the orientation or positional relationship indicated in the description of the direction and positional relationship is based on the orientation or positional relationship shown in the accompanying drawings. It is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present utility model.

[0083] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include one or more of the said features. In the description of the present utility model, "a plurality of" means two or more, unless otherwise specifically defined.

[0084] The following disclosure provides many different embodiments or examples for implementing different structures of the present utility model. To simplify the disclosure of the present utility model, the components and settings of specific examples are described below. Of course, they are merely examples and are not intended to limit the present utility model. In addition, the present utility model may repeat reference numerals and / or reference letters in different examples. Such repetition is for the purpose of simplification and clarity and does not itself indicate the relationship between the various embodiments and / or settings discussed. In addition, the present utility model provides examples of various specific processes and materials, but those of ordinary skill in the art may be aware of the application of other processes and / or the use of other materials.

[0085] Please refer to Figures 1 to 5 , the POCT fully automatic chemiluminescence device 100 of the embodiment of the present utility model includes:

[0086] An installation frame 10;

[0087] A reaction chamber assembly 20 provided on the installation frame 10, the reaction chamber assembly 20 can reciprocate along the length direction of the installation frame 10, and the reaction chamber assembly 20 is used for loading reagent strips 30;

[0088] A PMT assembly 40 provided at the rear end of the installation frame 10 and above the reaction chamber assembly 20, the reaction chamber assembly 20 is used to move the reagent strip 30 to the PMT assembly 40, and the PMT assembly 40 is used to detect the luminescence value of the detection position of the reagent strip 30; and

[0089] A multi-channel parallel pre-treatment device 50 provided on the installation frame 10 and in front of the PMT assembly, the multi-channel parallel pre-treatment device 50 is located relatively above the reaction chamber assembly 20 and can reciprocate along the length direction of the installation frame 10, and the multi-channel parallel pre-treatment device 50 is used to aspirate and discharge samples from the reagent strip 30 and transfer magnetic microparticles.

[0090] In the POCT fully automatic chemiluminescence device 100 according to the embodiment of the present utility model, by movably arranging the multi-channel parallel pre-treatment device 50 in the installation frame 10, the multi-channel parallel pre-treatment device 50 can move relative to the reaction chamber assembly 20, thereby accelerating the speed at which the reagent strip 30 moves to the multi-channel parallel pre-treatment device 50, and further accelerating the pre-treatment speed of the multi-channel parallel pre-treatment device 50 for the reagent strip 30, so as to achieve the purpose of improving the analysis efficiency of the POCT fully automatic chemiluminescence device 100.

[0091] In addition, when the reagent strip 30 is used for multiple detection items and the length of the reagent strip 30 becomes longer, in order to enable the multi-channel parallel pre-treatment device 50 to quickly pre-treat the reagent strip 30, the reaction chamber assembly 20 does not need to move the reagent strip 30 over a long distance, but can shorten the moving distance between the multi-channel parallel pre-treatment device 50 and the reagent strip 30 through the relative movement of the multi-channel parallel pre-treatment device 50, which is convenient for the multi-channel parallel pre-treatment device 50 to perform pre-treatment between the respective holes of the reagent strip 30. While controlling the volume of the POCT fully automatic chemiluminescence device 100, the POCT fully automatic chemiluminescence device 100 can achieve efficient detection of multiple detection items.

[0092] Specifically, the POCT fully automatic chemiluminescence device 100 according to the embodiment of the present utility model is generally in a rectangular body shape. The installation frame 10 is the basic structure of the POCT fully automatic chemiluminescence device 100. The installation frame 10 may include a bottom plate, a plurality of side plates provided on the bottom plate, a top plate, etc. The installation frame 10 surrounded by the bottom plate, the plurality of side plates and the top plate is also generally in a rectangular body shape.

[0093] The installation frame 10 is used to carry and install the above-mentioned reaction chamber assembly 20, PMT assembly 40, multi-channel parallel pre-treatment device 50 and other components, provide stable support for the above-mentioned components and protect the above-mentioned components from interference by external impurities, water vapor, etc.

[0094] In the embodiment of the present utility model, the reaction chamber assembly 20 may be arranged on the bottom plate of the installation frame 10. Driving elements such as motors and rails extending along the length direction of the installation frame 10 may be arranged on the bottom plate. A sliding seat corresponding to the rail may be arranged at the bottom of the reaction chamber assembly 20. Through the cooperation of the sliding seat and the rail, the reaction chamber assembly 20 can be slidably arranged on the installation frame 10 to achieve reciprocating movement, and then move the reagent strip 30 to the corresponding position for corresponding detection and analysis.

[0095] Please refer to Figure 14 And Figure 15, a plurality of accommodating grooves 211 arranged in parallel can be formed on the reaction chamber assembly 20. The accommodating grooves 211 extend along the length direction of the reaction chamber assembly 20. The reagent strips 30 are loaded in the accommodating grooves 211. The plurality of accommodating grooves 211 can accommodate a plurality of reagent strips 30, that is, the reaction chamber assembly 20 can drive the plurality of reagent strips 30 to move in the POCT fully automatic chemiluminescence device 100, so that the POCT fully automatic chemiluminescence device 100 can sequentially perform multi-channel detection and analysis on the plurality of reagent strips 30.

[0096] The reagent strip 30 is generally in a long strip shape. One end of it can be provided with a handle 31, and the handle 31 can be provided with anti-slip patterns to increase the friction between the reagent strip 30 and the operator's fingers, facilitating the operator to hold it firmly. The reagent strip 30 is a disposable consumable and can be directly discarded and destroyed after use.

[0097] Taking the reagent strip 30 that can be used for multiplex detection as an example, a sample hole, a tip head hole, one or more disposable magnetic separation sleeve holes, a plurality of magnetic labeled ligand holes, a plurality of enzyme labeled ligand holes, a plurality of cleaning liquid holes, and a plurality of substrate reading holes (i.e., the above-mentioned detection positions) can be sequentially arranged from one end of the handle 31 to the other end of the reagent strip 30.

[0098] Among them, the sample hole is used to add a blood sample, such as whole blood or serum. A tip head 32 is provided in the tip head hole. A disposable magnetic separation sleeve 33 is provided in the disposable magnetic separation sleeve hole. The magnetic labeled ligand hole contains a magnetic labeled ligand. The enzyme labeled ligand hole contains an enzyme labeled ligand. The ligand includes, but is not limited to, hapten, antigen, monoclonal antibody, polyclonal antibody, and nucleic acid ligand. The cleaning liquid hole contains a cleaning liquid. The substrate reading hole contains a substrate reading. In addition, after the corresponding reagent is packaged in the corresponding hole position of the reagent strip 30, the surface of the reagent strip 30 can be heat-sealed with a film to prevent the reagent in each hole position from volatilizing, leaking, or being contaminated, and it is also convenient for the storage and transportation of the reagent strip 30.

[0099] The tip head 32 is a hollow structure with a sharp end for breaking the sealing film on each hole position. A perforation is opened on the end, so that the tip head 32 can be used to transfer samples or reagents. The disposable magnetic separation sleeve 33 can be used to adsorb, mix, clean, and transfer magnetic particles. The cleaning liquid hole can be used to clean the magnetic particles. The substrate reading hole is used to perform chemiluminescence reaction and supply the PMT component 40 to read the luminescence value.

[0100] Since the reaction chamber assembly 20 is arranged on the bottom plate of the mounting frame 10, the PMT assembly 40 can be arranged above the bottom plate through a bracket or other structure, that is, the PMT assembly 40 is located relatively above the reaction chamber assembly 20. To ensure that the PMT assembly 40 can detect the luminescence values ​​of all reagent strips 30 in the reaction chamber assembly 20, the PMT assembly 40 can move up, down, left and right in the mounting frame 10, that is, it can move in the vertical direction and the horizontal direction (the width direction of the mounting frame 10), so as to approach or move away from the reagent strip 30 and move back and forth between multiple reagent strips 30.

[0101] Similarly, the multi-channel parallel pretreatment device 50 can also be arranged above the bottom plate through a bracket or other structure, that is, the multi-channel parallel pretreatment device 50 is located relatively above the reaction chamber assembly 20. To ensure that the multi-channel parallel pretreatment device 50 can pre-treat all reagent strips 30 in the reaction chamber assembly 20, the multi-channel parallel pretreatment device 50 can also move up and down in the mounting frame 10, that is, move in the vertical direction, so as to approach or move away from the reagent strip 30 to transfer samples or reagents, break the sealing film on the holes of the reagent strip 30, and adsorb, mix, clean and transfer magnetic particles.

[0102] Multi-channel parallel processing can be understood as processing multiple reagent strips 30 in multiple channels at the same time, and the processing before the sample is transferred to the substrate reading hole for chemiluminescent reaction can be understood as pre-processing. In the embodiment of the utility model, the multi-channel parallel pre-processing device 50 may include two parts, one part of the structure is used to combine with the tip head 32 to transfer samples or reagents and break the sealing film of each hole, and the other part of the structure is used to combine with the disposable magnetic separation sleeve 33 to adsorb, mix, wash and transfer magnetic particles.

[0103] Please continue reading Figures 2 to 5 Furthermore, a first driving element 51 and a first guide rail 52 are provided on the bottom plate of the mounting frame 10. The first driving element 51 is located at the rear end of the mounting frame 10. The first guide rail 52 extends along the length direction of the mounting frame 10. The multi-channel parallel pre-processing device 50 is transmission-connected to the first driving element 51 and is movably arranged with the first guide rail 52.

[0104] Specifically, the first driving element 51 provides power for the reciprocating movement of the multi-channel parallel pre-processing device 50, and can be a driving element such as a lead screw motor or a stepper motor. The lead screw motor has high movement accuracy and the stepper motor has high transmission efficiency, and can be selected according to specific needs.

[0105] The first driving element 51 is arranged at the rear end of the mounting frame 10 and combined with the first guide rail 52 extending along the length direction of the mounting frame 10, so that the moving distance of the multi-channel parallel pre-treatment device 50 in the mounting frame 10 is long enough and it can stably reciprocate in the mounting frame 10, thereby ensuring that it can stably move relative to the reaction chamber assembly 20 for a long enough distance to accelerate the pre-treatment speed.

[0106] Please refer to Figures 5 to 10 , further, the multi-channel parallel pre-treatment device 50 includes:

[0107] A gantry 53 arranged on the bottom plate of the mounting frame 10, the gantry 53 is movably arranged with the first guide rail 52 and is in transmission connection with the first driving element 51, and a second driving element 54 is arranged at the top of the gantry 53;

[0108] A sample extraction mechanism 55 arranged on the gantry 53, the sample extraction mechanism 55 is in transmission connection with the second driving element 54 and can be lifted and lowered under the drive of the second driving element 54 to aspirate and discharge the sample on the reagent strip 30;

[0109] A sample pre-treatment mechanism 56 arranged on the gantry 53, the sample pre-treatment mechanism 56 is in transmission connection with the second driving element 54 and can be lifted and lowered under the drive of the second driving element 54 to transfer the magnetic particles on the reagent strip 30.

[0110] Specifically, the gantry 53 can be made of metal materials such as stainless steel, iron, aluminum and various alloys, etc., with high strength, which can improve the service life of the multi-channel pre-treatment device. The gantry 53 spans the width direction of the mounting frame 10, so that the sample extraction mechanism 55 and the sample pre-treatment mechanism 56 can span above the reaction chamber assembly 20 to realize multi-channel parallel pre-treatment.

[0111] A sliding seat can be arranged at the bottom of the gantry 53 to cooperate with the first guide rail 52, so that the gantry 53 is movably arranged with the first guide rail 52, or a sliding groove can be arranged at the bottom of the gantry 53 to cooperate with the first guide rail 52 to realize movable arrangement. By transmitting the drive shaft of the gantry 53 and the first driving element 51, the reciprocating movement of the multi-channel parallel pre-treatment device 50 in the mounting frame 10 can be realized through the drive of the first driving element 51 on the gantry 53.

[0112] In the embodiment of the utility model, the second driving element 54 can be a screw motor, which has high movement accuracy and more accurate and stable position adjustment. The second driving element 54 arranged on the top of the gantry 53 drives the sample extraction mechanism 55 and the sample pre-processing mechanism 56 to rise and fall on the gantry 53, so that the sample extraction mechanism 55 and the sample pre-processing mechanism 56 are close to or away from the reagent strip 30, so that the sample extraction mechanism 55 cooperates with the tip head 32 on the reagent strip 30 to achieve functions such as breaking the membrane, transferring samples or transferring reagents, and the sample pre-processing mechanism 56 cooperates with the disposable magnetic separation sleeve 33 on the reagent strip 30 to achieve the adsorption, mixing, cleaning and transfer of magnetic particles.

[0113] In addition, the sample pre-processing mechanism 56 and the sample extraction mechanism 55 are located on opposite sides of the gantry 53 , such as the sample pre-processing mechanism 56 is located on one side of the gantry 53 close to the PMT assembly 40 , and the sample extraction mechanism 55 is located on the other side of the gantry 53 .

[0114] In this way, it is possible to avoid placing the sample pretreatment mechanism 56 and the sample extraction mechanism 55 on the same side of the gantry 53, which would cause crowded space and heavy load on one side of the gantry 53, resulting in inconvenient operation and unstable structure of the gantry 53. In addition, the sample extraction mechanism 55 and the sample pretreatment mechanism 56 can be made to correspond to reagent holes with different functions on the reagent strip 30 respectively. For example, the front section of the reagent strip 30 requires more participation of the sample extraction mechanism 55, while the rear section requires more participation of the sample pretreatment mechanism 56, which can further improve the pretreatment speed of the reagent strip 30 by the multi-channel parallel pretreatment device 50.

[0115] See also Figure 4 and Figure 5 Furthermore, in one embodiment of the utility model, a first driving pulley 511 is provided on the transmission shaft of the first driving element 51, a first mounting seat 11 is provided at the front end of the bottom plate of the mounting frame 10, a first driven pulley 111 is provided on the first mounting seat 11, the first driving pulley 511 is connected to the first driven pulley 111 through a belt, and a first synchronous belt pressure plate connected to the belt is provided at the bottom of the gantry 53.

[0116] Specifically, the first driving element 51 is located at the rear end of the mounting frame 10, and the first mounting seat 11 is located at the front end of the mounting frame 10, so that the connection between the two can cover the length direction of the mounting frame 10, so that the moving distance of the multi-channel parallel pre-processing device 50 in the mounting frame 10 can be long enough to better cooperate with the movement of the reaction chamber assembly 20.

[0117] The transmission structure composed of the first driving pulley 511, the belt, the first synchronous belt pressing plate and the first driven pulley 111 has high transmission efficiency, simple structure and sufficient power. Combined with the setting of the first guide rail 52, it can ensure that the multi-channel parallel pre-treatment device 50 moves stably and quickly in the installation frame 10, and speeds up the moving speed of the multi-channel parallel pre-treatment device 50.

[0118] In the embodiment of the present utility model, there are two sets of the first driving element 51 and the above-mentioned belt transmission structure, which are respectively arranged on the left and right sides of the installation frame 10 to ensure the stable driving of the gantry 53.

[0119] Furthermore, in another embodiment of the present utility model, the first driving element 51 is a lead screw motor, and the transmission lead screw of the first driving element 51 is in transmission connection with the bottom end of the gantry 53.

[0120] Specifically, the lead screw motor has high motion accuracy and is more accurate and stable in position adjustment. The transmission connection between the first driving element 51 and the gantry 53 can be a threaded connection. For example, the transmission lead screw of the first driving element 51 is provided with a thread, and the bottom end of the gantry 53 is provided with a threaded hole. The threaded connection can be realized by passing the transmission lead screw into the threaded hole. The stability of the threaded connection is better and it is easy to disassemble and assemble.

[0121] Of course, in other embodiments, the transmission connection manner between the first driving element 51 and the gantry 53 can also be other, not limited to the above-mentioned threaded connection, and can be specifically set according to specific requirements.

[0122] Please refer to Figure 6 、 Figure 9 and Figure 11 , furthermore, the sample extraction mechanism 55 includes:

[0123] The first mounting bracket 551 is arranged on the gantry 53 and is in transmission connection with the second driving element 54, and the second driving element 54 can drive the first mounting bracket 551 to lift and lower;

[0124] The third driving element 552 is arranged on the first mounting bracket 551; and

[0125] The extraction assembly 553 is arranged on the first mounting bracket 551 and is in transmission connection with the third driving element 552. The third driving element 552 can drive the extraction assembly 553 to act in the vertical direction to suck and spit samples.

[0126] Specifically, the second driving element 54 can drive the first mounting frame 551 to rise and fall, thereby driving the sample extraction mechanism 55 to rise and fall, so as to perform corresponding processing such as aspirating and discharging samples on the reagent strip 30. The first mounting frame 551 can be substantially "L"-shaped, and includes a two-part structure, such as a horizontal extension plate and a vertical extension plate. The third driving element 552 can be arranged on the horizontal extension plate to ensure a stable setting, thereby providing stable power for the lifting and lowering of the extraction component 553.

[0127] The extraction component 553 is arranged on the vertical extension plate, and the third driving element 552 can be a screw motor. The screw motor has high movement accuracy and is more accurate and stable in position adjustment. Its transmission shaft (i.e., transmission screw) passes through the horizontal extension plate and extends downward to be connected to the extraction component 553. The transmission connection between the two can be a threaded connection, which can ensure the stability of the connection between the two. At the same time, the third driving element 552 can make the extraction component 553 move smoothly and accurately in the vertical direction through threaded driving, so as to smoothly and accurately suck out the sample after contacting with the sample.

[0128] In addition, a photoelectric switch can be set on one side of the top of the gantry 53, and a baffle can be set on the corresponding side of the first mounting frame 551. When the first mounting frame 551 drives the baffle to move to the photoelectric switch to disconnect the sensing of the photoelectric switch, it indicates that the sample extraction mechanism 55 has moved to the set height. At this time, the power supply of the second driving element 54 can be disconnected to avoid overload and damage of the second driving element 54, thereby saving power consumption.

[0129] Furthermore, a slider may be provided on one side of the first mounting frame 551 facing the gantry frame 53, and a slide rail extending along the height direction of the gantry frame 53 may be provided on one side of the gantry frame 53 facing the first mounting frame 551, and the slider is slidably connected to the slide rail. The slider and the slide rail are in two groups, which are respectively provided on both sides of the gantry frame 53 and the first mounting frame 551. Through the cooperation of the two groups of sliders and the slide rails, the second driving element 54 can drive the first mounting frame 551 to rise and fall smoothly on the gantry frame 53, thereby ensuring that the sample extraction mechanism 55 rises and falls smoothly and accurately.

[0130] See also Figure 6 , Figure 8 and Figure 11 , further, the extraction component 553 includes:

[0131] An injection device 5531 is arranged on the first mounting frame 551, wherein a syringe cavity is formed in the injection device 5531, and a first loading head 5532 for loading the tip head 32 is arranged at the bottom of the injection device 5531, and the first loading head 5532 is communicated with the syringe cavity;

[0132] A first push plate 5533 disposed above the injection device 5531, the first push plate 5533 being drivingly connected to the third driving element 552; and

[0133] A piston rod 5534 disposed on the first push plate 5533, the piston rod 5534 being movably and sealingly connected to the syringe cavity, and the third driving element 552 can drive the first push plate 5533 to drive the piston rod 5534 to move up and down in the syringe cavity to perform suction and discharge actions.

[0134] Specifically, the injection device 5531 is generally rectangular parallelepiped-shaped, and is distributed along the width direction of the first mounting bracket 551, so that the syringe cavity can be distributed in the width direction of the extraction assembly 553 to correspond to the location of the reagent strip 30. The injection device 5531 also has a certain height to ensure that the space of the syringe cavity is large enough, so that a sufficient suction and discharge force can be generated when the piston rod 5534 moves in the syringe cavity.

[0135] There is an interference fit between the first loading head 5532 and the tip head 32, so as to ensure the stability of the tip head 32 loaded on the first loading head 5532. When the second driving element 54 drives the first mounting bracket 551 to drive the extraction assembly 553 to descend, the corresponding sealing film on the reagent strip 30 can be broken through by the tip head 32 loaded on the first loading head 5532. The first loading head 5532 is communicated with the syringe cavity, which enables the syringe cavity to be communicated with the tip head 32. When the piston rod 5534 is pushed to move up and down in the syringe cavity, the sample can be sucked and discharged through the tip head 32.

[0136] The transmission shaft of the third driving element 552 extends downward through the top of the first mounting bracket 551 and the first push plate 5533. A fixing member threadedly connected to the transmission shaft can be provided on the transmission shaft, and the first push plate 5533 can be fixed to the fixing member. When the transmission shaft of the third driving element 552 moves, the first push plate 5533 can be driven by the fixing member to move up and down to realize the up and down movement of the piston rod 5534.

[0137] Alternatively, a threaded hole can also be provided on the first push plate 5533, and a thread can be provided on the transmission shaft of the third driving element 552. The transmission shaft is threadedly connected to the first push plate 5533. In this way, the connection stability between the two can be ensured, and the third driving element 552 can also drive the first push plate 5533 to move up and down by means of threaded driving.

[0138] In this embodiment, the end of the piston rod 5534 in the syringe cavity can be sealed with the syringe cavity through a sealing ring (such as a rubber ring or a plastic ring, etc.). When the piston rod 5534 is driven upward by the first push plate 5533 and rises in the syringe cavity, a negative pressure is generated in the syringe cavity, causing the tip 32 to aspirate the sample. When the piston rod 5534 is pushed downward by the first push plate 5533 and descends in the syringe cavity, a positive pressure is generated in the syringe cavity, causing the tip 32 to eject the sample.

[0139] Please refer to Figure 8 and Figure 11 , in the embodiment of the present utility model, there are multiple syringe cavities, and the multiple syringe cavities are evenly distributed at intervals along the length direction of the injection device 5531; there are multiple first loading heads 5532, and the multiple first loading heads 5532 are evenly distributed at intervals along the length direction of the injection device 5531; there are multiple piston rods 5534, and the multiple piston rods 5534 are evenly distributed at intervals along the length direction of the first push plate 5533; that is, the multiple piston rods 5534, the multiple syringe cavities and the multiple piston rods 5534 correspond one by one, so as to realize multi-channel parallel processing of multiple reagent strips 30.

[0140] Furthermore, to ensure the smooth lifting and lowering of the extraction assembly 553 on the first mounting bracket 551, two slide rails extending in the vertical direction can be provided on the extraction assembly 553, and two sliders adapted to the slide rails are provided on the first push plate 5533. The two slide rails and the two sliders are respectively located on both sides of the extraction assembly 553, and the stable movement of the extraction assembly 553 on the first mounting bracket 551 is realized through the cooperation of the two slide rails and the two sliders.

[0141] Moreover, a photoelectric switch can be provided at the top of the first mounting bracket 551, and a baffle is provided on the corresponding side of the first push plate 5533. When the first push plate 5533 drives the baffle to move to the photoelectric switch and the photoelectric switch disconnects the induction, it indicates that the first push plate 5533 has moved to the set height, that is, it indicates that the piston rod 5534 has been reset. At this time, the power supply of the third driving element 552 can be disconnected to avoid overloading and damage of the third driving element 552.

[0142] Please refer to Figure 11 , furthermore, the sample extraction mechanism 55 further includes:

[0143] A push rod 5535 that can be lifted and lowered through the injection device 5531, and the top end of the push rod 5535 is spaced from the first push plate 5533;

[0144] An elastic element 5536 sleeved on the push rod 5535 located in the injection device 5531, and the elastic element 5536 expands or contracts simultaneously when the push rod 5535 moves up and down relative to the injection device 5531; and

[0145] A separation plate 5537 is provided at the bottom of the injection device 5531. The first loading head 5532 passes through the separation plate 5537. The bottom end of the push rod 5535 is connected to the separation plate 5537, and the push rod 5535 can drive the separation plate 5537 to move up and down relative to the first loading head 5532.

[0146] In the embodiment of the present utility model, a through hole is formed in the separation plate 5537, and the size of the through hole is smaller than the size of the connection part between the tip 32 and the first loading head 5532. Therefore, the tip 32 loaded on the first loading head 5532 can be removed by the arrangement of the separation plate 5537. Specifically, since the top end of the push rod 5535 is spaced from the first push plate 5533, when the first push plate 5533 is pushed down by the third driving element 552 by a certain height until it contacts the top end of the push rod 5535, the first push plate 5533 pushes the push rod 5535 to descend in the injection device 5531, thereby pushing the separation plate 5537 located at the bottom of the injection device 5531 to descend and abut against the tip 32, so as to push the tip 32 to separate from the first loading head 5532.

[0147] After the separation of the tip 32 is completed, the third driving element 552 stops driving, and the elastic element 5536 will stretch to generate an upward thrust on the push rod 5535, driving the separation plate 5537 to reset. The compression of the elastic element 5536 can provide a certain buffering force for the descent of the push rod 5535, avoiding damage to the tip 32 caused by too fast a descent speed of the push rod 5535, or pressing the tip 32 on the reagent strip 30, resulting in offset and shaking of the reagent strip 30.

[0148] In the embodiment of the present utility model, there are two push rods 5535 and elastic elements 5536, which are respectively arranged on both sides of the injection device 5531 to ensure the smooth pushing of the separation plate 5537 by the push rod 5535, thereby ensuring the separation effect on the tip 32 and ensuring the smooth reset of the separation plate 5537 by the elastic element 5536.

[0149] Exemplarily, the process of the sample extraction mechanism 55 sucking and discharging samples (and transferring / mixing reagents) is roughly as follows:

[0150] The reaction chamber assembly 20 drives the reagent strip 30 to move. At the same time, the first driving element 51 drives the gantry 53 to move relative to the reaction chamber assembly 20. When the two move relative to each other to the corresponding position, that is, when the multi-channel parallel pre-treatment device 50 (sample extraction mechanism 55) moves relative to the reaction chamber assembly 20 to the corresponding position, the second driving element 54 drives the first mounting bracket 551 to descend until the first loading head 5532 is fixedly engaged with the tip 32 on the reagent strip 30.

[0151] After the tip head 32 is loaded, the reaction chamber assembly 20 drives the reagent strip 30 to move and / or the first driving element 51 drives the multi-channel parallel pre-processing device 50 to move, until the tip head 32 moves to above the sample hole, and at the same time, the third driving element 552 first drives the piston rod 5534 to descend a certain height or to the lowest point in the syringe cavity, and then the second driving element 54 drives the first mounting frame 551 to descend a certain height until the tip of the tip head 32 extends into the sample, and the third driving element 552 drives the piston rod 5534 to rise to absorb the sample through the tip head 32, and then the second driving element 54 drives the first mounting frame 551 to rise to make the tip head 32 separate from the sample liquid surface, and the reaction chamber assembly 20 drives the reagent strip 30 to move and / or the first driving element 51 drives the multi-channel parallel pre-processing device 50 to move, until the tip head 32 with the sample absorbed moves to directly above the target hole position.

[0152] The second driving element 54 drives the first mounting frame 551 to descend, driving the tip head 32 with the sample absorbed to descend until its tip is inserted below the liquid surface of the reagent. The third driving element 552 drives the piston rod 5534 to descend to inject the sample in the tip head 32 into the reagent. Then, the second driving element 54 drives the first mounting frame 551 to rise until the tip head 32 is separated from the reagent. The third driving element 552 drives the piston rod 5534 to rise to its original position to realize the suction and transfer of the sample, and then the tip head 32 is retracted into the hole of the tip head 32.

[0153] The reagent transfer process is the same as the sample transfer process and will not be described in detail here.

[0154] If multiple transfers are required, the tip 32 can be repeatedly loaded and the suction and injection actions can be repeated. In addition, the sample extraction mechanism 55 can also be used to mix the reagents, and the third driving element 552 is controlled to drive the piston rod 5534 to rise and fall repeatedly in the syringe cavity, so that the tip 32 repeatedly sucks and discharges under the reagent liquid surface, so that the reagents or samples that need to react can be fully mixed and reacted.

[0155] See also Figures 7 to 9 and Figure 12 Furthermore, the sample pre-processing mechanism 56 includes:

[0156] A second mounting frame 561 is disposed on the gantry 53 and is in driving connection with the second driving element 54. The second driving element 54 can drive the second mounting frame 561 to rise and fall;

[0157] a fourth driving element 562 disposed on the second mounting frame 561; and

[0158] A pretreatment assembly 563 is disposed on the second mounting bracket 561 and is in transmission connection with the fourth driving element 562. The fourth driving element 562 can drive the pretreatment assembly 563 to move in the vertical direction to transfer magnetic particles.

[0159] Specifically, the second driving element 54 can drive the second mounting bracket 561 to lift, thereby driving the sample pretreatment mechanism 56 to lift, so as to perform corresponding treatments such as transferring magnetic particles on the reagent strip 30. The second mounting bracket 561 can be generally in an "L" shape, and it includes two parts of structures, such as a horizontally extending plate and a vertically extending plate. The fourth driving element 562 can be disposed on the above-mentioned horizontally extending plate to ensure stable setting, thereby providing stable power for the lifting of the pretreatment assembly 563.

[0160] The pretreatment assembly 563 is disposed on the vertically extending plate. The fourth driving element 562 can be a lead screw motor. The lead screw motor has high motion accuracy and is more accurate and stable in position adjustment. Its transmission shaft (i.e., the transmission lead screw) passes through the horizontally extending plate and then extends downward to be in transmission connection with the pretreatment assembly 563. The transmission connection between the two can be a threaded connection, which can not only ensure the connection stability between the two, but also enable the fourth driving element 562 to make the pretreatment assembly 563 move smoothly and accurately in the vertical direction through the threaded driving method, so as to stably and accurately adsorb magnetic particles and then transfer magnetic particles.

[0161] Furthermore, to ensure the smooth lifting of the pretreatment assembly 563 on the second mounting bracket 561, a slide rail extending in the vertical direction can be provided on the second mounting bracket 561, and a slider adapted to the slide rail can be provided on the second push plate 5633. The stable movement of the pretreatment assembly 563 on the second mounting bracket 561 is realized through the cooperation of the slide rail and the slider.

[0162] On the other side of the second mounting bracket 561, that is, on the side where the second mounting bracket 561 faces the gantry 53, sliders can also be provided. On the side where the gantry 53 faces the second mounting bracket 561, slide rails extending in the height direction of the gantry 53 can be provided. The sliders are slidably connected to the slide rails, and there are two groups of sliders and slide rails, which are respectively disposed on the left and right sides of the gantry 53 and the second mounting bracket 561. Through the cooperation of the two groups of sliders and slide rails, it can be ensured that the second driving element 54 drives the second mounting bracket 561 to lift smoothly on the gantry 53, and further ensure the smooth and accurate lifting of the sample pretreatment mechanism 56.

[0163] In addition, a photoelectric switch can be provided on one side of the top of the gantry 53, and a baffle can be provided on the corresponding side of the second mounting bracket 561. When the second mounting bracket 561 drives the baffle to move to the photoelectric switch and the photoelectric switch disconnects the induction, it indicates that the sample pretreatment mechanism 56 has moved to the set height. At this time, the power supply of the fourth driving element 562 can be disconnected to avoid overloading and damage of the fourth driving element 562.

[0164] In the embodiment of the utility model, the sample extraction mechanism 55 is opposite to the sample pre-processing mechanism 56 on the gantry 53, and the sample extraction mechanism 55 is located in front of the sample pre-processing mechanism 56, and the second driving element 54, the third driving element 552 and the fourth driving element 562 are arranged linearly on the top of the gantry 53, so that the top structure distribution of the multi-channel parallel pre-processing device 50 is regular, and the three driving elements are basically concentrated in the middle position of the gantry 53 when exerting force, so that the gantry 53 is evenly stressed and not prone to shaking or deviation.

[0165] See also Figure 8 , Figure 9 and Figure 12 , further, the pre-processing component 563 includes:

[0166] A magnetic bar device 5631 is arranged on the second mounting frame 561, wherein an active through hole is formed in the magnetic bar device 5631, and a second loading head 5632 for loading the disposable magnetic separation sleeve 33 is arranged at the bottom of the magnetic bar device 5631, and the second loading head 5632 is communicated with the active through hole;

[0167] a second push plate 5633 disposed above the magnetic bar device 5631, the second push plate 5633 being drivingly connected to the fourth driving element 562; and

[0168] A connecting rod 5634 is arranged on the second pushing plate 5633, and a magnetic rod 5635 is arranged on the free end of the connecting rod 5634. The fourth driving element 562 can drive the second pushing plate 5633 to drive the magnetic rod 5635 to rise and fall in the corresponding movable through hole so as to be separated from the second loading head 5632 or pass through the second loading head 5632.

[0169] Specifically, the magnetic rod device 5631 is roughly in the shape of a rectangular parallelepiped and is distributed along the width direction of the second mounting frame 561, so that the active through holes therein can be distributed in the width direction of the pre-processing component 563 to correspond to the location of the reagent strip 30. When the disposable magnetic separation sleeve 33 needs to be loaded, the second driving element 54 drives the second mounting frame 561 to descend to the second loading head 5632 to contact and load the disposable magnetic separation sleeve 33, and the two are interference fit, thereby ensuring the stability of the disposable magnetic separation sleeve 33 loaded on the second loading head 5632 and facilitating separation.

[0170] The second loading head 5632 is in communication with the movable through hole, so that the movable through hole is in communication with the disposable magnetic separation sleeve 33. When the fourth driving element 562 drives the connecting rod 5634 to drive the magnetic rod 5635 to pass through the second loading head 5632 and extend into the disposable magnetic separation sleeve 33, the magnetic microparticles can be adsorbed through the disposable magnetic separation sleeve 33. When it is necessary to separate the disposable magnetic separation sleeve 33, control the fourth driving element 562 to drive the magnetic rod 5635 to descend until it abuts against the bottom end of the disposable magnetic separation sleeve 33, and the disposable magnetic separation sleeve 33 can be withdrawn from the second loading head 5632. When the fourth driving element 562 drives the connecting rod 5634 to drive the magnetic rod 5635 to be spaced from the second loading head 5632 and separate from the disposable magnetic separation sleeve 33, the magnetic microparticles can be separated from the disposable magnetic separation sleeve 33 to achieve transfer.

[0171] In addition, on the basis of transferring the magnetic microparticles, the pretreatment assembly 563 can also be used to transfer the magnetic microparticles into the reagent for reaction and mixing, or separate the magnetic microparticles in the reaction solution into the cleaning solution, or transfer the magnetic microparticles into the substrate reading for reaction and complete the luminescence detection.

[0172] The transmission shaft of the fourth driving element 562 extends downward through the top of the second mounting bracket 561 and the second pushing plate 5633. A fixing member threadedly connected to the transmission shaft can be provided on the transmission shaft, and the second pushing plate 5633 can be fixed to the fixing member. When the transmission shaft of the fourth driving element 562 moves, the second pushing plate 5633 can be driven to lift and lower through the fixing member to realize the lifting and lowering of the magnetic rod 5635.

[0173] Alternatively, a threaded hole can also be provided on the second pushing plate 5633, and a thread can be provided on the transmission shaft of the fourth driving element 562. The transmission shaft is threadedly connected to the second pushing plate 5633. In this way, not only the connection stability between the two can be ensured, but the fourth driving element 562 can also drive the second pushing plate 5633 to lift and lower by means of threaded driving.

[0174] Please refer to Figure 7 and Figure 12 , further, the magnetic rods 5635 are arranged in multiple rows, and the multiple rows of magnetic rods 5635 are evenly spaced along the width direction of the second pushing plate 5633. The number of rows of the magnetic rods 5635 is equal to the number of substrate reading holes to realize the detection of multiple items, that is, realize multiplex detection; each row of magnetic rods 5635 has multiple magnetic rods, and the multiple magnetic rods 5635 are evenly spaced along the length direction of the second pushing plate 5633. The number of magnetic rods 5635 in each row is equal to the number of reagent strips 30, so as to realize the multi-channel parallel processing of multiple reagent strips 30.

[0175] In the embodiment of the present utility model, the magnetic rod 5635 has three rows, enabling the detection of three items. The space occupied by the three-row magnetic rod 5635 is not large, and it can achieve three-item detection, capable of realizing multiplex detection while controlling the volume of the POCT fully automatic chemiluminescence device 100.

[0176] Certainly, in other embodiments, the magnetic rod 5635 can also have two rows, four rows or even more rows to achieve the detection of different numbers of items.

[0177] The sample pretreatment mechanism 56 in the embodiment of the present utility model can reciprocally magnetize by driving the lifting of the magnetic rod 5635 through the fourth driving element 562, with higher magnetic separation efficiency. The multi-channel parallel separation process further improves the separation and transfer efficiency of magnetic particles. At the same time, by realizing the reciprocating movement of the disposable magnetic separation sleeve 33 through the fourth driving element 562, the mixing of the reaction liquid and the resuspension of the cleaning liquid can also be completed.

[0178] Exemplarily, the process of the sample pretreatment mechanism 56 transferring magnetic particles is roughly as follows:

[0179] After the sample is injected into the corresponding reagent hole of the reagent strip 30, the reaction chamber assembly 20 drives the reagent strip 30 to move. At the same time, the first driving element 51 drives the gantry 53 to move relative to the reaction chamber assembly 20 to the corresponding position, so that the sample pretreatment mechanism 56 is located directly above the disposable magnetic separation sleeve. At this time, the second driving element 54 drives the second mounting bracket 561 to descend a certain height until the disposable magnetic separation sleeve is loaded on the second loading head 5632. The second driving element 54 drives the second mounting bracket 561 to rise, and the disposable magnetic separation sleeve is driven by the second loading head 5632 to rise to a certain height.

[0180] After that, the reaction chamber assembly 20 and / or the sample pretreatment assembly 563 move until the sample pretreatment assembly 563 loaded with the disposable magnetic separation sleeve moves above the corresponding hole of the reagent strip 30. The fourth driving element 562 drives the magnetic rod 5635 to descend until the magnetic rod 5635 contacts the bottom of the disposable magnetic separation sleeve 33. At this time, the second driving element 54 drives the second mounting bracket 561 to descend a certain height, so that the disposable magnetic separation sleeve extends into the liquid containing magnetic particles (such as the magnetic labeled ligand above) until the disposable magnetic separation sleeve contacts the bottom of the magnetic labeled ligand hole, so that the magnetic particles are gradually adsorbed to the end of the disposable magnetic separation sleeve 33. Multiple slow lifts and drops can be performed to fully complete the adsorption of magnetic particles.

[0181] After the magnetic particles are adsorbed, control the second driving element 54 to drive the second mounting bracket 561 to rise. At this time, all the magnetic particles are adsorbed on the outer wall of the disposable magnetic separation sleeve 33. Control the reaction chamber assembly 20 and / or the sample pretreatment assembly 563 to move to above the disposable magnetic separation sleeve 33 located in the cleaning liquid. The second driving element 54 drives the second mounting bracket 561 to descend until the disposable magnetic separation sleeve 33 extends into the cleaning liquid. Then, the fourth driving element 562 drives the magnetic rod 5635 to rise from the disposable magnetic separation sleeve 33, causing the magnetic field to disappear. The magnetic particles then separate from the outer wall of the disposable magnetic separation sleeve 33 and fall off into the cleaning liquid.

[0182] To accelerate the separation process of the magnetic particles, the second driving element 54 can drive the second mounting bracket 561 to rise and fall repeatedly at different frequencies, so that the magnetic particles move repeatedly in the cleaning liquid, thereby ensuring the full mixing and suspension of the magnetic particles and the cleaning liquid. After the magnetic particles are completely detached from the outer wall of the disposable magnetic separation sleeve 33, the second driving element 54 drives the second mounting bracket 561 to rise to the initial height, completing one operation of separating, cleaning, and mixing the magnetic particles. If multiple magnetic separation and cleaning operations are required, repeat the above operations.

[0183] Similarly, if it is necessary to transfer the magnetic particles to other holes, just control the second driving element 54 to drive the second mounting bracket 561 to descend until the disposable magnetic separation sleeve 33 extends to the bottom of the corresponding liquid level. Then control the fourth driving element 562 to drive the magnetic rod 5635 to descend until it contacts the bottom end of the disposable magnetic separation sleeve 33, so that all the magnetic particles are adsorbed on the outer wall of the disposable magnetic separation sleeve 33, and control the second driving element 54 to drive the second mounting bracket 561 to rise.

[0184] After that, control the sample pretreatment mechanism 56 and / or the reaction chamber assembly 20 to move until the disposable magnetic separation sleeve 33 adsorbed with magnetic particles moves to directly above the target hole. Then control the second driving element 54 to drive the second mounting bracket 561 to descend until the disposable magnetic separation sleeve 33 extends into the target liquid. At this time, control the fourth driving element 562 to drive the magnetic rod 5635 to rise to make the magnetic field disappear, and the magnetic particles can gradually separate into the target liquid. By controlling the second driving element 54 to drive the second mounting bracket 561 to rise and fall repeatedly, the disposable magnetic separation sleeve 33 can move repeatedly in the target liquid to accelerate the separation of the magnetic particles.

[0185] Please refer to Figure 9 and Figure 10 . Further, there is an activity space 531 on the gantry 53. The transmission shaft of the second driving element 54 passes through the activity space 531. A transmission plate 532 is sleeved on the transmission shaft. There is a thread on the transmission shaft, and a threaded hole is provided on the transmission plate 532. Therefore, when the transmission shaft moves, the transmission plate 532 can be lifted and lowered synchronously in the activity space 531 by means of screw transmission.

[0186] In addition, a first connecting portion is provided on one side of the first mounting bracket 551 facing the gantry 53. The first connecting portion is formed by the vertical extension plate of the first mounting bracket 551 extending towards the gantry 53. A second connecting portion is provided on one side of the second mounting bracket 561 facing the gantry 53. The second extension portion is formed by the vertical extension plate of the second mounting bracket 561 extending towards the gantry 53. Both the first connecting portion and the second connecting portion are connected to the transmission plate 532 by fasteners (such as screws). Therefore, when the transmission plate 532 rises and falls along with the transmission shaft of the second driving element 54, the first mounting bracket 551 and the second mounting bracket 561 can be driven to rise and fall, that is, the sample extraction mechanism 55 and the sample pretreatment mechanism 56 are lifted on the gantry 53.

[0187] Please refer to Figure 2 、 Figure 3 、 Figure 14 and Figure 15 , further, the reaction chamber assembly 20 includes:

[0188] A second guide rail provided on the bottom plate of the mounting frame 10;

[0189] A reaction chamber main body 21 provided on the second guide rail. A slider slidably connected to the second guide rail is provided at the bottom of the reaction chamber main body 21. A plurality of uniformly spaced accommodation grooves 211 for loading reagent strips 30 are provided on the reaction chamber main body 21. The accommodation grooves 211 extend along the length direction of the reaction chamber main body 21;

[0190] A fifth driving element provided on the bottom plate of the mounting frame 10 and located at the rear end of the second guide rail. A second driving pulley is provided on the transmission shaft of the fifth driving element;

[0191] A second mounting seat provided on the bottom plate of the mounting frame 10 and located at the front end of the second guide rail. A second driven pulley is provided on the second mounting seat. The second driving pulley is connected to the second driven pulley by a belt; and

[0192] A second synchronous belt pressing plate provided on one side of the reaction chamber main body 21. The second synchronous belt pressing plate is connected to the belt.

[0193] Specifically, the reaction chamber assembly 20 may include a bearing plate for bearing the reaction chamber main body 21. The slider is provided at the bottom of the bearing plate and is slidably connected to the second guide rail. The second guide rail extends along the length direction of the mounting frame 10. Through the sliding connection between the second guide rail and the slider, the reaction chamber assembly 20 can move smoothly along the length direction of the mounting frame 10. The shape of the accommodation groove 211 is adapted to the shape of the reagent strip 30, so that the reagent strip 30 can be stably loaded on the reaction chamber assembly 20, maintaining stability during the movement and pretreatment process, avoiding deviation and shaking, and avoiding situations such as reagent leakage from the reagent strip 30.

[0194] The fifth driving element is located at the rear end of the mounting frame 10, and the second mounting seat is located at the front end of the mounting frame 10, so that the connection between the two can cover the length direction of the mounting frame 10, so that the moving distance of the reaction chamber assembly 20 in the mounting frame 10 can be long enough to better cooperate with the movement of the multi-channel parallel pre-processing device 50.

[0195] The transmission structure composed of the second driving pulley, the belt, the second synchronous belt pressure plate and the second driven pulley has high transmission efficiency, simple structure and sufficient power. Combined with the setting of the second guide rail, it can ensure that the reaction chamber assembly 20 moves stably and quickly in the installation frame 10, thereby improving the movement efficiency of the reaction assembly 20.

[0196] Furthermore, a photoelectric switch for real-time detection of the position of the reaction chamber body 21 may be provided on the bottom plate of the mounting frame 10, and a baffle may be provided on the reaction chamber body 21. When the reaction chamber body 21 drives the baffle to move to the corresponding position and the baffle reaches the photoelectric switch, causing the photoelectric switch to disconnect the sensing, it indicates that the reaction chamber assembly 20 has reached the set position. At this time, the power supply of the fifth driving element can be disconnected to prevent the fifth driving element from continuing to work and causing overload and failure.

[0197] In addition, a heating module is also provided at the bottom of the reaction chamber body 21. The heating temperature of the heating module can be kept constant at human body temperature, i.e., 37°C. The temperature inside the reaction chamber body 21 is kept constant within a preset value range, thereby making the reagents in the reagent strip 30 meet the temperature conditions for chemiluminescence determination.

[0198] See also Figure 2 , Figure 3 and Figure 13 , further, the PMT assembly 40 comprises:

[0199] A mounting bracket 41 provided on the bottom plate of the mounting frame 10;

[0200] A third mounting bracket 42 disposed on the mounting bracket 41;

[0201] A fourth mounting frame 43 disposed at the bottom of the third mounting frame 42;

[0202] A PMT module 44 disposed on a fourth mounting frame 43;

[0203] A sixth driving element 45 is disposed on the top of the third mounting frame 42 and is transmission-connected to the fourth mounting frame 43. The sixth driving element 45 can drive the fourth mounting frame 43 to move up and down to drive the PMT module 44 to move up and down;

[0204] The seventh driving element 46 and the third driven pulley 47 are respectively arranged on both sides of the top of the mounting bracket 41. A third driving pulley is provided on the transmission shaft of the seventh driving element 46. The third driving pulley is in transmission connection with the third driven pulley 47 through a belt; and

[0205] The third synchronous belt pressing plate is arranged on the third mounting bracket 42, and the third synchronous belt pressing plate is connected to the belt.

[0206] In the embodiment of the present utility model, the structure of the mounting bracket 41 can be similar to the structure of the gantry 53, and it also spans the width direction of the mounting frame 10, so that the PMT module 44 can move above the reaction chamber assembly 20 to realize chemiluminescence detection. Moreover, the mounting bracket 41 can also be made of metal materials, such as stainless steel, iron, aluminum and various alloys, etc., with high strength, which can improve the service life of the PMT assembly 40.

[0207] The third mounting bracket 42 is used to mount the sixth driving element 45, providing stable support for the sixth driving element 45, so that the sixth driving element 45 is stably located at the top of the mounting bracket 41. The fourth mounting bracket 43 is used to mount the PMT module 44, and it is in transmission connection with the sixth driving element 45, so that the PMT module 44 can realize lifting movement under the drive of the sixth driving element 45.

[0208] The third mounting bracket 42 is in belt transmission connection, which can drive the fourth mounting bracket 43 and the PMT module 44 thereon to move horizontally, and the PMT module 44 can move up, down, left and right on the mounting bracket 41 through the combination of the sixth driving element 45 and the seventh driving element 46.

[0209] In the embodiment of the present utility model, the sixth driving element 45 can be a lead screw motor. The fourth mounting bracket 43 is driven by the sixth driving element 45 arranged on the top of the mounting bracket 41 to lift, so as to drive the lifting of the PMT module 44, so that the PMT assembly 40 can approach or move away from the reagent strip 30. And the lead screw motor has high movement accuracy, and the position adjustment of the PMT module 44 is more accurate and stable, so that the PMT assembly 40 can accurately and stably detect the luminescence value at the detection position on the reagent strip 30.

[0210] The seventh driving element 46 can be a stepping motor. It is located on one side (such as the right side) of the top of the mounting bracket 41, while the third driven pulley 47 is located on the other side (such as the left side) of the top of the mounting bracket 41, so that the connection between the two can cover the length direction of the mounting bracket 41, so that the movement of the PMT module 44 on the mounting bracket 41 can cover the width range of the mounting frame 10.

[0211] The transmission structure composed of the third driving pulley, the belt, the third synchronous belt pressure plate and the third driven pulley 47 has high transmission efficiency, simple structure and sufficient power. The belt can increase the moving speed of the PMT module 44 and thus improve the detection efficiency, enabling the PMT assembly 40 to quickly move and switch between the respective reagent strips 30 of the reaction chamber assembly 20 for luminescence value detection respectively.

[0212] Furthermore, the POCT fully automatic chemiluminescence device 100 may further include components such as a control module, an electrical module, a display module, an image acquisition module and an alarm module. The control module is electrically connected to the electrical module, the display module, the image acquisition module and the alarm module, and the electrical module is also electrically connected to the display module, the image acquisition module and the alarm module.

[0213] Among them, the electrical module can be used to provide power support for the entire device, and the control module is used to achieve the working control of the device, such as controlling the opening and closing of each driving element, the opening and closing of the heating module, the display of the display module, and the image acquisition and image conversion of the image acquisition module, etc. The display module can be used to display data such as the operating parameters of the device and the project analysis results, etc. The image acquisition module can be used to photograph and monitor the pre-processing work of the multi-channel parallel pre-processing device 50. When abnormal work is monitored, the alarm module (such as sound and light alarm, display alarm, etc.) can be controlled by the control module to issue corresponding warnings.

[0214] The components such as the control module, the electrical module, the display module, the image acquisition module and the alarm module do not involve the creative points of the present invention, so they will not be described in detail here, but only their connection relationships and basic functions will be simply described. If there are unclear points, those skilled in the art can refer to the structures, positions and functions of the components such as the control module, the electrical module, the display module, the image acquisition module and the alarm module in the related art.

[0215] In the description of this specification, the descriptions referring to terms such as "Embodiment 1", "Embodiment 2", etc. mean that the specific features, structures, materials or characteristics described in connection with the embodiments or examples are included in at least one embodiment or example of the present invention. In this specification, the schematic expressions of the above terms do not necessarily refer to the same embodiments or examples. Moreover, the specific features, structures, materials or characteristics described can be combined in a suitable manner in any one or more embodiments or examples.

[0216] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A POCT fully automatic chemiluminescence device, characterized in that: include: Install the frame; A reaction chamber assembly disposed on the mounting frame, the reaction chamber assembly being reciprocatable along the length direction of the mounting frame, and the reaction chamber assembly being used for loading a reagent strip; a PMT assembly disposed at the rear end of the mounting frame and located above the reaction chamber assembly, the reaction chamber assembly being used to move the reagent strip to the PMT assembly, the PMT assembly being used to detect the luminescence value of the detection position of the reagent strip; and A multi-channel parallel pre-processing device is arranged on the mounting frame and located in front of the PMT component. The multi-channel parallel pre-processing device is located above the reaction chamber component and can reciprocate along the length direction of the mounting frame. The multi-channel parallel pre-processing device is used to aspirate samples from the reagent strip and transfer magnetic particles.

2. The POCT fully automatic chemiluminescence device according to claim 1, characterized in that: A first driving element and a first guide rail are provided on the bottom plate of the mounting frame, the first driving element is located at the rear end of the mounting frame, the first guide rail extends along the length direction of the mounting frame, and the multi-channel parallel pre-processing device is transmission-connected to the first driving element and movably arranged with the first guide rail.

3. The POCT fully automatic chemiluminescence device according to claim 2, characterized in that: The multi-channel parallel pre-processing device comprises: a gantry provided on the bottom plate of the mounting frame, the gantry and the first guide rail being movably arranged and being in driving connection with the first driving element, and a second driving element being provided on the top of the gantry; a sample extraction mechanism disposed on the gantry, the sample extraction mechanism being in driving connection with the second driving element and being capable of rising and falling under the driving of the second driving element to suck and discharge the sample on the reagent strip; and The sample pre-processing mechanism is arranged on the gantry, and is drivingly connected with the second driving element, and can be lifted and lowered under the driving of the second driving element to transfer the magnetic particles on the reagent strip.

4. The POCT fully automatic chemiluminescence device according to claim 3, characterized in that: A first driving pulley is provided on the transmission shaft of the first driving element, a first mounting seat is provided at the front end of the base plate of the mounting frame, a first driven pulley is provided on the first mounting seat, the first driving pulley is connected to the first driven pulley through a belt, and a first synchronous belt pressure plate connected to the belt is provided at the bottom of the gantry.

5. The POCT fully automatic chemiluminescence device according to claim 3, characterized in that: The first driving element is a screw motor, and the transmission screw of the first driving element is transmission-connected to the bottom end of the gantry.

6. The POCT fully automatic chemiluminescence device according to claim 3, characterized in that: The sample extraction mechanism comprises: A first mounting frame provided on the gantry and drivingly connected to the second driving element, wherein the second driving element can drive the first mounting frame to rise and fall; a third driving element disposed on the first mounting frame; and An extraction component is arranged on the first mounting frame and is transmission-connected to the third driving element. The third driving element can drive the extraction component to move in a vertical direction to suck and discharge samples.

7. The POCT fully automatic chemiluminescence device according to claim 6, characterized in that: The extraction component comprises: An injection device is arranged on the first mounting frame, wherein a syringe cavity is formed in the injection device, a first loading head for loading a tip head is arranged at the bottom of the injection device, and the first loading head is communicated with the syringe cavity; a first push plate disposed above the injection device, the first push plate being drivingly connected to the third driving element; and The piston rod is arranged on the first push plate, and the piston rod is movably and sealedly connected to the syringe cavity. The third driving element can drive the first push plate to drive the piston rod to rise and fall in the syringe cavity to perform a suction and exhalation action.

8. The POCT fully automatic chemiluminescence device according to claim 7, characterized in that: The sample extraction mechanism also includes: A push rod that can be lifted and lowered and passes through the injection device, wherein the top end of the push rod is spaced apart from the first push plate; an elastic element sleeved on the push rod in the injection device, wherein the elastic element is stretched or compressed simultaneously when the push rod is lifted or lowered relative to the injection device; and A separation plate is arranged at the bottom of the injection device, the first loading head passes through the separation plate, the bottom end of the push rod is connected to the separation plate, and the push rod can drive the separation plate to rise and fall relative to the first loading head.

9. The POCT fully automatic chemiluminescence device according to claim 7, characterized in that: There are multiple syringe cavities, and the multiple syringe cavities are evenly distributed along the length direction of the injection device; There are a plurality of first loading heads, and the plurality of first loading heads are evenly spaced and distributed along the length direction of the injection device; There are multiple piston rods, and the multiple piston rods are evenly distributed along the length direction of the first push plate.

10. The POCT fully automatic chemiluminescence device according to claim 6, characterized in that: The sample pre-processing mechanism comprises: A second mounting frame provided on the gantry and drivingly connected to the second driving element, wherein the second driving element can drive the second mounting frame to rise and fall; a fourth driving element disposed on the second mounting frame; and A pre-processing component is arranged on the second mounting frame and is transmission-connected to the fourth driving element. The fourth driving element can drive the pre-processing component to move in a vertical direction to transfer magnetic particles.

11. The POCT fully automatic chemiluminescence device according to claim 10, characterized in that: The pre-processing component comprises: A magnetic bar device is arranged on the second mounting frame, wherein an active through hole is formed in the magnetic bar device, and a second loading head for loading a disposable magnetic separation sleeve is arranged at the bottom of the magnetic bar device, and the second loading head is communicated with the active through hole; a second push plate disposed above the magnetic bar device, the second push plate being drivingly connected to the fourth driving element; and A connecting rod is arranged on the second pushing plate, and a magnetic bar is arranged on the free end of the connecting rod. The fourth driving element can drive the second pushing plate to drive the magnetic bar to rise and fall in the corresponding movable through hole so as to be separated from the second loading head or pass through the second loading head.

12. The POCT fully automatic chemiluminescence device according to claim 11, characterized in that: The magnetic bars are arranged in multiple rows, and the magnetic bars in the multiple rows are evenly distributed on the second push plate along the width direction of the second push plate; There are multiple magnetic bars in each row, and the multiple magnetic bars are evenly distributed on the second pushing plate along the length direction of the second pushing plate at intervals.

13. The POCT fully automatic chemiluminescence device according to claim 10, characterized in that: The sample extraction mechanism is opposite to the sample pre-processing mechanism, and the sample extraction mechanism is located in front of the sample pre-processing mechanism, and the second driving element, the third driving element and the fourth driving element are linearly arranged on the top of the gantry.

14. The POCT fully automatic chemiluminescence device according to claim 10, characterized in that: The gantry is provided with an activity space, the transmission shaft of the second driving element passes through the activity space, a transmission plate is sleeved on the transmission shaft, and the transmission plate can be raised and lowered in the activity space when the transmission shaft moves; A first connection portion is provided on a side of the first mounting frame facing the gantry, and a second connection portion is provided on a side of the second mounting frame facing the gantry. Both the first connection portion and the second connection portion are connected to the transmission plate.

15. The POCT fully automatic chemiluminescence device according to claim 1, characterized in that: The reaction chamber assembly comprises: A second guide rail disposed on the bottom plate of the mounting frame; A reaction chamber body disposed on the second guide rail, wherein a slider slidably connected to the second guide rail is disposed at the bottom of the reaction chamber body, and a plurality of evenly spaced receiving grooves for loading reagent strips are disposed on the reaction chamber body, wherein the receiving grooves extend along the length direction of the reaction chamber body; a fifth driving element disposed on the bottom plate of the mounting frame and located at the rear end of the second guide rail, wherein a second driving pulley is disposed on the transmission shaft of the fifth driving element; a second mounting seat disposed on the bottom plate of the mounting frame and located at the front end of the second guide rail, the second mounting seat being provided with a second driven pulley, the second driving pulley being transmission-connected to the second driven pulley via a belt; and A second synchronous belt pressure plate is arranged on one side of the reaction chamber body, and the second synchronous belt pressure plate is connected to the belt.

16. The POCT fully automatic chemiluminescence device according to claim 1, characterized in that: The PMT assembly includes: A mounting bracket disposed on the bottom plate of the mounting frame; a third mounting bracket disposed on the mounting bracket; a fourth mounting frame disposed at the bottom of the third mounting frame; A PMT module disposed on the fourth mounting frame; A sixth driving element disposed on the top of the third mounting frame and drivingly connected to the fourth mounting frame, the sixth driving element can drive the fourth mounting frame to move up and down to drive the PMT module to move up and down; A seventh driving element and a third driven pulley are respectively arranged on both sides of the top of the mounting bracket, a third driving pulley is arranged on the transmission shaft of the seventh driving element, and the third driving pulley is connected to the third driven pulley through a belt; and A third synchronous belt pressure plate is arranged on the third mounting frame, and the third synchronous belt pressure plate is connected to the belt.

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