Multifunctional automatic precise cell subpackaging equipment

Abstract

The utility model provides multifunctional automatic precise cell subpackaging equipment, and relates to the technical field of biomedical treatment. The multifunctional automatic precise cell subpackaging equipment comprises a control device, a cell constant-temperature shaking device and at least one cell subpackaging device, wherein the control device is provided with a plurality of connecting ports; the cell constant-temperature shaking device is used for uniformly mixing cell sap in the cell preparation bag at a preset temperature; and the cell subpackaging device and the cell constant-temperature shaking device are electrically connected with the corresponding connecting ports. According to the multifunctional automatic precise cell subpackaging equipment provided by the utility model, the cell subpackaging device, the control device and the cell constant-temperature shaking device are modularly arranged, the control device is provided with a plurality of connecting ports, and the cell subpackaging device and the cell constant-temperature shaking device are electrically connected with the corresponding connecting ports; in the installation process, different numbers of cell subpackaging devices can be installed according to actual requirements, so that different numbers of preparation bags are subpackaged, and the production requirements of different scales are met.

Description

Technical Field

[0001] The utility model relates to the technical field of biological medicine, in particular to a multifunctional automatic precision cell dispensing device. Background Art

[0002] With the development of the cell therapy industry, the demand for expanding the production capacity of cell preparation dispensing is increasing day by day. For the existing cell preparation dispensing devices on the market, when dispensing multiple bags of cell preparations, they can only dispense a fixed number of preparation bags and cannot be compatible with production requirements of different scales. Content of the Utility Model

[0003] The utility model provides a multifunctional automatic precision cell dispensing device to solve the problem that the existing dispensing devices cannot be compatible with production requirements of different scales.

[0004] The utility model provides a multifunctional automatic precision cell dispensing device, including:

[0005] A control device, which is provided with a plurality of connection ports;

[0006] A cell constant temperature shaking device, which is used for uniformly mixing the cell liquid in the cell preparation bag at a predetermined temperature;

[0007] At least one cell dispensing device, both the cell dispensing device and the cell constant temperature shaking device are electrically connected to the corresponding connection ports.

[0008] According to the multifunctional automatic precision cell dispensing device provided by the utility model, the cell dispensing device includes:

[0009] A dispensing housing;

[0010] A plug valve chuck component, including a plurality of plug valve chuck assemblies, the plurality of plug valve chuck assemblies are arranged on the dispensing housing and are spaced along the width direction of the dispensing housing, and the plug valve chuck assembly is used for driving the plug valve of the consumable to switch channels.

[0011] According to the multifunctional automatic precision cell dispensing device provided by the utility model, the plug valve chuck assembly includes:

[0012] A plug valve chuck, which is located outside the dispensing housing and is used for clamping and rotating the plug valve;

[0013] A rotating shaft, the dispensing housing is provided with a mounting hole, and the first end of the rotating shaft passes through the mounting hole and is connected to the plug valve chuck;

[0014] The first driving mechanism, which is connected to the dispensing housing through a motor mounting plate. The rotating shaft of the first driving mechanism is connected to the second end of the rotating shaft. The first driving mechanism is used to drive the plug valve chuck to rotate so as to switch the channels of the plug valve.

[0015] According to a multifunctional cell automatic precision dispensing device provided by the present invention, the plug valve chuck assembly further includes:

[0016] The first sensor mechanism, including a first sensor and an angular position sensing piece. The angular position sensing piece is sleeved on the outer periphery of the rotating shaft, and a plurality of first notches are arranged at intervals on the edge of the angular position sensing piece; the first sensor is connected to the motor mounting plate, and the first sensor is used to detect the angle of rotation of the angular position sensing piece.

[0017] The origin sensing mechanism, including a second sensor and an origin sensing piece. The origin sensing piece is sleeved on the outer periphery of the rotating shaft and is located between the angular position sensing piece and the plug valve chuck. The second sensor is connected to the motor mounting plate, and the second sensor is used to detect whether the origin sensing piece is in the initial position.

[0018] According to a multifunctional cell automatic precision dispensing device provided by the present invention, the cell dispensing device further includes:

[0019] The fixing device, which includes at least one positioning component. The positioning component includes two positioning blocks, and the two positioning blocks are arranged at intervals along the width direction of the dispensing housing. The positioning blocks are in positioning cooperation with the clamping plate of the consumable.

[0020] According to a multifunctional cell automatic precision dispensing device provided by the present invention, the positioning component further includes:

[0021] At least one locking component, including an elastic buckle, an elastic member and a limiting member. The limiting member and the elastic buckle are oppositely arranged on the positioning block. The elastic buckle is rotatably matched with the positioning block through a pin shaft. The elastic member is arranged between the elastic buckle and the limiting member, and the elastic buckle is used to lock the clamping plate.

[0022] According to a multifunctional cell automatic precision dispensing device provided by the present invention, the positioning component further includes:

[0023] A positioning member, which is arranged on the positioning block. A positioning hole is arranged on the side of the clamping plate, and the positioning member is in positioning cooperation with the positioning hole.

[0024] According to a multifunctional cell automatic precision dispensing device provided by the present invention, the positioning component further includes:

[0025] A third sensor is disposed on the positioning block, and the third sensor is used to detect whether the clamping plate is installed in place.

[0026] According to a multifunctional cell automatic precision dispensing device provided by the present invention, the cell constant temperature shaking device includes:

[0027] A shaking housing, on one side of which there is an opening;

[0028] A first circuit board is disposed inside the shaking housing and is electrically connected to the corresponding connection port;

[0029] A constant temperature component is disposed inside the shaking housing. The constant temperature component is electrically connected to the first circuit board, and the constant temperature component is used to control the temperature inside the shaking housing;

[0030] A shaking component is disposed inside the shaking housing. The shaking component is electrically connected to the first circuit board, and the shaking component is used to uniformly mix the cell liquid in the cell preparation bag at a predetermined temperature;

[0031] A heat preservation opening and closing door is disposed at the opening of the shaking housing.

[0032] According to a multifunctional cell automatic precision dispensing device provided by the present invention, the control device includes:

[0033] An outer housing;

[0034] A main control circuit board is disposed inside the outer housing, and the main control circuit board is electrically connected to a plurality of the connection ports;

[0035] A display screen is connected to the outer housing through a movable arm, and the display screen is electrically connected to the main control circuit board.

[0036] For the multifunctional cell automatic precision dispensing device provided by the present invention, since the cell dispensing device, the control device, and the cell constant temperature shaking device are arranged in a modular manner, and the control device is provided with a plurality of connection ports, and both the cell dispensing device and the cell constant temperature shaking device are electrically connected to the corresponding connection ports, different numbers of cell dispensing devices can be installed according to actual needs during the installation process, so as to dispense different numbers of preparation bags, which is compatible with production requirements of different scales. Description of the Drawings

[0037] To more clearly illustrate the technical solutions in the present utility model or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are some embodiments of the present utility model. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0038] Figure 1 It is a schematic perspective view of the multi-functional cell automatic precision dispensing device provided by the present utility model.

[0039] Figure 2 It is a schematic perspective view of the cell dispensing device provided by the present utility model.

[0040] Figure 3 It is a schematic structural view of the syringe push-pull component provided by the present utility model.

[0041] Figure 4 It is a schematic structural view of the cock chuck assembly provided by the present utility model.

[0042] Figure 5 It is a schematic perspective view of the cell dispensing device and consumables provided by the present utility model.

[0043] Figure 6 It is a schematic perspective view of the positioning component provided by the present utility model.

[0044] Figure 7 It is a schematic perspective view of the positioning block provided by the present utility model.

[0045] Figure 8 It is a schematic perspective view of the fixing component provided by the present utility model.

[0046] Figure 9 It is a schematic perspective view of the positioning assembly provided by the present utility model.

[0047] Figure 10 It is a schematic perspective view of the consumables provided by the present utility model.

[0048] Figure 11 It is a schematic perspective view of the cell constant temperature shaking device provided by the present utility model.

[0049] Figure 12 It is a schematic perspective view of the control device provided by the present utility model.

[0050] Reference numerals:

[0051] 1. Cell constant temperature shaking device; 11. Shaking housing; 12. Constant temperature component; 13. Shaking component; 14. Heat preservation opening and closing door; 15. Glass;

[0052] 2. Cell sub-packaging device; 21. Sub-packaging housing; 22. Syringe push-pull component; 24. Stopcock chuck assembly; 25. Positioning component; 26. Fixing component;

[0053] 221. Syringe support plate; 222. Syringe clamping plate; 223. Second linear drive assembly; 224. Positioning assembly; 225. Limit groove; 226. Floating joint; 227. Limit hole; 228. First linear drive member; 229. Connection mechanism; 230. Fixing plate; 231. First position sensor; 232. First position sensing piece; 233. Second position sensor; 234. Second position sensing piece; 235. Guide shaft; 236. Oil-free bushing; 237. Positioning protrusion; 238. Positioning groove; 239. First guiding inclined plane; 240. Stopcock chuck; 241. Rotating shaft; 242. First drive mechanism; 243. First sensor; 244. Angular position sensing piece; 245. Second sensor; 246. Origin sensing piece; 247. First ball screw; 248. Second ball screw; 249. Snap ring; 250. Positioning block; 251. Elastic buckle; 252. Elastic member; 253. Limiting member; 254. Third sensor; 256. Second guiding inclined plane; 257. Motor mounting plate; 258. Syringe positioning plate; 261. Rotating handle; 262. Connecting shaft; 263. Fixed base; 264. Positioning disk; 265. Groove; 266. Third ball screw; 270. Industrial camera; 271. Bubble sensor group; 272. Second bubble sensor; 273. Cell sub-packaging module alarm light; 274. Consumable installation confirmation key; 275. Cell sub-packaging module power key;

[0054] 3. Control device; 31. Outer housing; 32. Display screen; 33. Moving arm; 34. Control and operation module power key; 35. Control and operation module alarm light; 36. Data cable interface; 220. First linear drive assembly;

[0055] 4. Consumables; 41. Cardboard; 42. Liquid path hose; 43. Syringe mounting plate; 44. Stopcock. Detailed implementation manners

[0056] To make the objectives, technical solutions and advantages of the present utility model clearer, the technical solutions in the present utility model will be clearly and completely described below with reference to the accompanying drawings in the present utility model. Obviously, the described embodiments are some but not all of the embodiments of the present utility model. All other embodiments obtained by those of ordinary skill in the art based on the embodiments in the present utility model without any creative effort shall fall within the protection scope of the present utility model.

[0057] The following is combined with Figures 1 - 12Describe the specific structure and working principle of the multifunctional cell automatic precision dispensing equipment of the present utility model.

[0058] As Figure 1 shown, the multifunctional cell automatic precision dispensing equipment includes a control device 3, a cell constant temperature shaking device 1, and at least one cell dispensing device 2. The control device 3 is provided with a plurality of connection ports. The cell constant temperature shaking device 1 is used to uniformly mix the cell liquid in the cell preparation bag at a predetermined temperature; both the cell dispensing device 2 and the cell constant temperature shaking device 1 are electrically connected to the corresponding connection ports.

[0059] Preferably, both the cell dispensing device 2 and the cell constant temperature shaking device 1 are electrically connected to the corresponding connection ports through aviation plugs.

[0060] For the multifunctional cell automatic precision dispensing equipment provided by the present utility model, since the cell dispensing device 2, the control device 3, and the cell constant temperature shaking device 1 are modularly arranged, and the control device 3 is provided with a plurality of connection ports, both the cell dispensing device 2 and the cell constant temperature shaking device 1 are electrically connected to the corresponding connection ports. During the installation process, different numbers of cell dispensing devices 2 can be installed according to actual needs, so as to dispense different numbers of preparation bags, accommodating production requirements of different scales.

[0061] As Figure 2 and Figure 3 shown, the cell dispensing device 2 includes a dispensing housing 21 and a syringe pushing and pulling component 22. The dispensing housing 21 has a cavity inside. The syringe pushing and pulling component 22 includes a first linear drive assembly 220, a syringe support plate 221, a syringe clamping plate 222, and a positioning component 224. The first linear drive assembly 220 is disposed in the cavity and connected to the dispensing housing 21. The syringe support plate 221 is connected to the first linear drive assembly 220. The positioning component 224 is disposed on the dispensing housing 21, and the positioning component 224 is used for positioning and cooperating with the syringe; the first linear drive assembly 220 is used to drive the syringe support plate 221 and the syringe clamping plate 222 to move in the first direction, so as to drive the piston rod of the syringe to move up and down in the first direction, so that the syringe discharges or sucks in liquid.

[0062] For the cell dispensing device 2 provided by the present utility model, the piston bottom of the syringe is clamped by the cooperation of the syringe clamping plate 222 and the syringe support plate 221; by using the first linear drive assembly to drive the movement of the syringe support plate 221 to push and pull the piston of the syringe for dispensing, the amount of injected liquid can be accurately controlled, and the dispensing speed can be flexibly adjusted. It should be noted here that the movement in the first direction refers to the up and down direction. Of course, the first direction can also refer to the horizontal direction.

[0063] In an embodiment of the present utility model, the syringe pushing and pulling component 22 further includes a second linear driving assembly 223. The second linear driving assembly 223 is disposed on the syringe supporting plate 221 and is connected to the syringe clamping plate 222. The second linear driving assembly 223 is used to drive the syringe clamping plate 222 to approach or move away from the syringe supporting plate 221 along the first direction, so as to clamp or loosen the bottom of the piston of the syringe.

[0064] In an embodiment of the present utility model, as Figure 2 and Figure 9 shown, the positioning assembly 224 includes a syringe positioning plate 258. The syringe positioning plate 258 is disposed on one side of the sub-packaging housing 21. The syringe positioning plate 258 is provided with two positioning protrusions 237. The two positioning protrusions 237 are arranged at intervals in the up-down direction. Both of the two positioning protrusions 237 are provided with clamping grooves for clamping and cooperating with the syringe. A positioning groove 238 is formed between the two positioning protrusions 237 for clamping and cooperating with the syringe mounting plate 43. The width of the positioning groove 238 is adapted to the thickness of the syringe mounting plate 43. When installing the syringe, since the openings of the clamping grooves and the opening of the positioning groove 238 both face away from the sub-packaging housing 21, the syringe can be easily clamped in the clamping grooves, and the syringe mounting plate 43 can be easily clamped in the positioning groove 238.

[0065] In a preferred embodiment of the present utility model, a first guiding inclined surface 239 is provided at the edge of the opening of the positioning groove 238. The first guiding inclined surface 239 inclines towards the inside of the positioning groove 238. By providing the first guiding inclined surface 239, the width of the positioning groove 238 is increased, so that the syringe mounting plate 43 can be easily clamped in the positioning groove 238.

[0066] In a preferred embodiment of the present utility model, mounting holes are provided in the inner wall of the positioning groove 238, and elastic positioning members are arranged in the mounting holes. A positioning hole is provided on one side of the syringe mounting plate 43 for positioning and cooperating with the elastic positioning members to fix the syringe to the syringe positioning plate 258. Preferably, the elastic positioning member is a first ball screw 247.

[0067] In an embodiment of the present utility model, as Figure 3 shown, the syringe clamping plate 222 has a plate-like structure and is horizontally arranged. A vertical strip-shaped hole is provided on one side of the sub-packaging housing 21. The first end of the syringe clamping plate 222 extends out of the sub-packaging housing 21 through the vertical strip-shaped hole. The width of the first end of the syringe clamping plate 222 is greater than the width of the second end of the syringe clamping plate 222.

[0068] A limiting groove 225 is provided at the first end of the syringe clamping plate 222. The limiting groove 225 is semi-circular, and the size of the limiting groove 225 is adapted to the size of the syringe. The syringe clamping plate 222 is clamped and matched with the end of the push rod of the syringe through the limiting groove 225, and the second end of the syringe clamping plate 222 is connected to the second linear driving assembly 223.

[0069] In an embodiment of the present utility model, since the width of the vertical strip-shaped hole is relatively large, which affects the aesthetics of the dispensing device, a baffle is provided in the vertical strip-shaped hole, and the baffle is vertically arranged. Correspondingly, a horizontal strip-shaped through hole is provided in the middle of the syringe clamping plate 222, and the baffle is inserted into the horizontal strip-shaped through hole. The provision of the baffle can not only block the vertical strip-shaped hole but also does not affect the movement of the syringe clamping plate 222.

[0070] In an embodiment of the present utility model, as Figure 3 shown, a clamping groove is provided at the second end of the syringe clamping plate 222. The clamping groove extends along the width direction of the syringe clamping plate 222. A floating joint 226 is provided on the telescopic shaft of the second linear driving assembly 223, and the floating joint 226 is clamped and matched with the clamping groove. Preferably, there is a gap between the floating joint 226 and the clamping groove, and the installation and disassembly of the dispensing device can be facilitated through the clamping and matching of the floating joint 226 and the clamping groove.

[0071] In an embodiment of the present utility model, as Figure 3 shown, the syringe support plate 221 has a plate-like structure. The syringe support plate 221 is horizontally arranged. A limiting hole 227 is provided at the first end of the syringe support plate 221. The limiting hole 227 is a circular through hole, and the size of the limiting hole 227 is adapted to the size of the syringe. The syringe support plate 221 is sleeved on the syringe through the limiting hole 227, and the second end of the syringe support plate 221 is connected to the first linear driving assembly 220.

[0072] In an embodiment of the present utility model, the width of the first end of the syringe support plate 221 is greater than the width of the second end of the syringe support plate 221. A horizontal strip-shaped through hole is provided in the middle of the syringe support plate 221, and the baffle is inserted into the horizontal strip-shaped through hole.

[0073] In an embodiment of the present utility model, as Figure 3As shown in the figure, the second linear drive assembly 223 includes a second lead screw motor. The second lead screw motor is disposed on the side of the syringe tray 221 away from the syringe clamping plate 222. The housing of the second lead screw motor is connected to the syringe tray 221 by screws. The telescopic shaft of the second lead screw motor passes through the syringe tray 221 and is then connected to the floating joint 226. When the telescopic shaft of the second lead screw motor extends, the syringe clamping plate 222 moves away from the syringe tray 221; when the telescopic shaft of the second lead screw motor shortens, the syringe clamping plate 222 moves closer to the syringe tray 221. During the process of the syringe clamping plate 222 moving closer to or away from the syringe tray 221, the syringe clamping plate 222 pushes and pulls the piston of the syringe for dispensing. Since the movement accuracy of the lead screw motor is relatively high, the amount of injected liquid can be precisely controlled, improving the dispensing accuracy.

[0074] Of course, the specific type of the second linear drive member is not limited to the lead screw motor, and it can also be a cylinder or other linear drive members.

[0075] In an embodiment of the present invention, as Figure 3 shown in the figure, the first linear drive assembly 220 includes a first linear drive member 228, a connecting mechanism 229, and a fixing plate 230. The first linear drive member 228, the connecting mechanism 229, and the fixing plate 230 are all located in the cavity. The fixing plate 230 is used to provide an installation basis for the first linear drive member 228. The fixing plate 230 is connected to the first linear drive member 228 and the dispensing housing 21. Specifically, a connecting plate is provided at the bottom of the fixing plate 230, and the connecting plate is connected to the dispensing housing 21 by screws. The first linear drive member 228 is disposed vertically on one side of the fixing plate 230, and the first linear drive member 228 is connected to the fixing plate 230 by screws. The first linear drive member 228 is connected to the second end of the syringe tray 221 through the connecting mechanism 229.

[0076] Preferably, the first linear drive member 228 is a lead screw motor module. The base of the lead screw motor module is connected to the fixing plate 230 by screws, and the slider of the lead screw motor module is connected to the connecting mechanism 229 by screws. Of course, the specific type of the first linear drive member 228 is not limited to the lead screw motor module, and it can also be a cylinder or other linear drive members.

[0077] In an embodiment of the present invention, the connecting mechanism 229 includes a mounting plate. The mounting plate is connected to the slider of the lead screw motor module by screws, and the second end of the syringe tray 221 is connected to the mounting plate by screws.

[0078] In an embodiment of the present invention, as Figure 3As shown, the syringe pushing and pulling component 22 further includes a first sensor assembly. The first sensor assembly includes a first position sensor 231 and a first position sensing piece 232. The first position sensor 231 is disposed on the first linear driving member 228, and the first position sensing piece 232 is disposed on the connecting mechanism 229. Specifically, the first position sensing piece 232 is disposed on one side of the mounting plate. When the first linear driving member 228 drives the connecting mechanism 229 to move, the connecting mechanism 229 drives the first position sensing piece 232 to move. The first position sensor 231 determines the position of the connecting mechanism 229 by detecting the position of the first position sensing piece 232, and finally calculates the positions of the syringe support plate 221, the syringe clamping plate 222, and the second linear driving assembly 223.

[0079] Preferably, the first sensor assembly includes three first position sensors 231 and two first position sensing pieces 232. The three first position sensors 231 are arranged at intervals in the up and down direction on one side of the base of the lead screw motor module, and the two first position sensing pieces 232 are arranged at intervals in the up and down direction on one side of the mounting plate.

[0080] When the lead screw motor module drives the mounting plate to move up and down, the first position sensing piece 232 moves up and down together with the mounting plate. The first position sensor 231 determines the position of the syringe support plate 221 by detecting the position of the first position sensing piece.

[0081] In an embodiment of the present invention, as Figure 3 shown, the syringe pushing and pulling component 22 further includes a second sensor assembly. The second sensor assembly includes a second position sensor 233 and a second position sensing piece 234. The second position sensor 233 is disposed on the connecting mechanism 229. Specifically, the second position sensor 233 is disposed on the mounting plate; the second position sensing piece 234 is disposed on one side of the syringe clamping plate 222.

[0082] When the telescopic shaft of the second lead screw motor extends, the syringe clamping plate 222 moves away from the syringe support plate 221, causing the second position sensing piece 234 to move away from the second position sensor 233; when the telescopic shaft of the second lead screw motor shortens, the syringe clamping plate 222 moves closer to the syringe support plate 221, causing the second position sensing piece 234 to move closer to the second position sensor 233 and finally enter the sensing range of the second position sensor 233. At this time, the second position sensor 233 outputs an electrical signal, indicating that the liquid in the syringe has been output completely.

[0083] In an embodiment of the present invention, as Figure 3As shown, the syringe push-pull component 22 further includes a guiding assembly, which includes a guiding shaft 235 and an oil-free bushing 236. The guiding shaft 235 is disposed on one of the syringe support plate 221 and the syringe clamping plate 222. The guiding shaft 235 is vertically arranged. The oil-free bushing 236 is disposed on the other of the syringe support plate 221 and the syringe clamping plate 222. Preferably, the other of the syringe support plate 221 and the syringe clamping plate 222 is provided with a mounting hole, and the oil-free bushing 236 is embedded in the mounting hole. The position of the oil-free bushing 236 corresponds to the position of the guiding shaft 235 one by one. The oil-free bushing 236 is sleeved on the outer periphery of the guiding shaft 235 and is slidably engaged with the guiding shaft 235 in the first direction.

[0084] Preferably, the syringe push-pull component 22 further includes two guiding assemblies, which are symmetrically arranged on both sides of the floating joint 226. Two connecting holes are provided on the side of the syringe clamping plate 222 facing the syringe support plate 221, and one end of each of the two guiding shafts 235 is correspondingly inserted into the two connecting holes. Two mounting holes are provided on the side of the syringe support plate 221 facing the syringe clamping plate 222, and the two oil-free bushings 236 are correspondingly embedded in the two mounting holes, and the other ends of the two guiding shafts 235 are correspondingly inserted into the two oil-free bushings 236.

[0085] During the up and down movement of the syringe clamping plate 222 driven by the telescopic shaft of the second lead screw motor, due to the guiding cooperation between the guiding shaft 235 and the oil-free bushing 236, the movement of the syringe clamping plate 222 can be made more stable.

[0086] In an embodiment of the present invention, as Figure 2 and Figure 3 shown, the cell dispensing device 2 further includes a fixing device, which includes at least one positioning component 25, a positioning component 25 and a stopcock chuck component. The positioning component 25 is disposed on the dispensing housing 21. The positioning component 25 is used for positioning and cooperating with the clamping plate 41 of the consumable 4 so that the consumable 4 is fixed to one side of the dispensing housing 21. The stopcock chuck component is disposed on the dispensing housing 21. Preferably, the stopcock chuck component is located on one side of the dispensing housing 21. The stopcock chuck component is used for driving the stopcock 44 of the consumable 4 to switch channels.

[0087] In an embodiment of the present invention, as Figure 3 shown, the positioning component 25 includes two positioning blocks 250, and the two positioning blocks 250 are arranged at intervals along the width direction of the dispensing housing 21. The positioning blocks 250 are connected to the dispensing housing 21. Preferably, the positioning blocks 250 are connected to the dispensing housing 21 by screws. The positioning blocks 250 are positioned and cooperate with the clamping plate 41 of the consumable 4. Specifically, the positioning blocks 250 are provided with notches, and the clamping plate 41 is clamped in the notches.

[0088] Preferably, the cell dispensing device 2 further comprises two positioning components 25, one positioning component 25 is arranged at the upper part of one side of the dispensing housing 21, and the other positioning component 25 is arranged at the middle part of one side of the dispensing housing 21, the notches of the two positioning blocks 250 at the upper part face downward, and the notches of the two positioning blocks 250 at the lower part face upward. During installation, the four corners of the clamping plate 41 are clamped in the notches of the four positioning blocks 250 to fix the clamping plate 41.

[0089] In one embodiment of the present invention, Figure 6 As shown, the positioning component 25 also includes at least one locking assembly, which includes an elastic buckle 251, an elastic member 252 and a limiting member 253. The limiting member 253 and the elastic buckle 251 are arranged on the positioning block 250 relative to each other. The elastic buckle 251 is rotatably matched with the positioning block 250 through a pin shaft. The elastic member 252 is arranged between the elastic buckle 251 and the limiting member 253. The elastic buckle 251 is used to lock the card plate 41. The elastic member 252 can be a V-shaped spring or a torsion spring. Under the elastic action of the elastic member 252, the elastic buckle 251 abuts against the side of the card plate 41 away from the packaging shell 21, thereby preventing the consumables 4 from separating from the positioning block 250.

[0090] Preferably, one positioning block 250 in each positioning component 25 is provided with a locking component, such as Figure 1 As shown, in the upper positioning component 25, the left positioning block 250 is provided with a locking assembly, and in the lower positioning component 25, the right positioning block 250 is provided with a locking assembly, so that one diagonal of the card plate 41 can be locked, effectively improving the stability of the consumables 4 after installation. Of course, in the upper positioning component 25, the right positioning block 250 can also be provided with a locking assembly, and in the lower positioning component 25, the left positioning block 250 can be provided with a locking assembly.

[0091] In one embodiment of the present invention, Figure 7 As shown, the positioning component 25 also includes a positioning piece, which is arranged on the positioning block 250. The side of the card plate 41 is provided with a positioning hole, and the positioning piece cooperates with the positioning hole. The positioning piece cooperates with the positioning hole to further improve the stability of the card plate 41 after it is installed in place.

[0092] Preferably, the positioning member is a second ball-end screw 248, the side wall of the notch is provided with a mounting hole, the second ball-end screw 248 is embedded in the mounting hole, and the ball of the second ball-end screw 248 protrudes from the edge of the mounting hole. When the clamping plate 41 is installed in place, the ball abuts against the positioning hole to achieve positioning cooperation with the positioning hole.

[0093] Preferably, a second guiding inclined surface 256 is provided at the edge of the notch, and the second guiding inclined surface 256 inclines towards the inside of the notch. When the mounting clamping plate 41 is installed, the clamping plate 41 is in sliding fit with the second guiding inclined surface 256, which can make the clamping plate 41 easily enter the notch and be locked by the positioning member and the locking member. By the cooperation of the second guiding inclined surface 256 with the positioning member and the locking member, the rapid installation of the consumable 4 can be realized, the assembly time of the consumable 4 is shortened, and the dispensing efficiency is improved.

[0094] In an embodiment of the present utility model, as Figure 5 and Figure 6 shown, the positioning member 25 further includes a third sensor 254. The third sensor 254 is arranged on the positioning block 250, and the third sensor 254 is used to detect whether the clamping plate 41 is installed in place. The third sensor 254 can be a contact switch or other sensors. After the clamping plate 41 is snapped into the notch, the clamping plate 41 contacts the third sensor 254, triggering the third sensor 254 to output an electrical signal, indicating that the clamping plate 41 is installed in place.

[0095] In an embodiment of the present utility model, as Figure 8 shown, the cell dispensing device 2 further includes a fixing member 26. The fixing member 26 includes a rotating handle 261, a connecting shaft 262, a fixing base 263 and a positioning disk 264. The fixing base 263 is connected to the dispensing housing 21. The inside of the fixing base 263 is hollow. The positioning disk 264 is rotatably arranged inside the fixing base 263. One end of the connecting shaft 262 is connected to the rotating handle 261, and the other end of the connecting shaft 262 is connected to the positioning disk 264.

[0096] The outer peripheral surface of the positioning disk 264 is provided with grooves 265, and the grooves 265 extend along the central axis of the positioning disk 264. In this embodiment, four grooves 265 are provided, and the four grooves 265 are symmetrically arranged in pairs. Preferably, two first grooves 265 are in a first plane, and the other two first grooves 265 are in a second plane, and the first plane is perpendicular to the second plane. Of course, the number of the grooves 265 is not limited to four, and six, eight or more numbers can also be set. Two third ball screws 266 are arranged on the inner wall of the fixing base 263, and the two third ball screws 266 are symmetrically arranged.

[0097] The pallet 41 is provided with locking holes, the positions of the locking holes correspond to the positions of the rotary handle 261 one by one, and the shape of the locking holes is adapted to the shape of the rotary handle 261. The rotary handle 261 is adapted to switch between an open state and a locked state. In the open state, the rotary handle 261 is in a vertical state, and the third ball screw 266 in the fixed base 263 is in positioning cooperation with the groove 265 to keep the rotary handle 261 in the open state. In the open state, the rotary handle 261 can pass through the locking hole of the pallet 41. When the rotary handle 261 is rotated 90°, the rotary handle 261 is in the locked state. In the locked state, the rotary handle 261 is in a horizontal state, and the third ball screw 266 in the fixed base 263 is in positioning cooperation with the groove 265 to keep the rotary handle 261 in the locked state; at this time, the rotary handle 261 cannot pass through the locking hole of the pallet 41, thereby realizing the locking of the pallet 41.

[0098] In an embodiment of the present utility model, the cell aliquoting device 2 further includes a second circuit board, which is arranged inside the aliquoting housing 21, and the second circuit board is electrically connected to the third sensor 254. The second circuit board is electrically connected to the corresponding interface through a wire.

[0099] In an embodiment of the present utility model, Figure 2 As shown, the plug valve chuck assembly includes a plurality of plug valve chuck assemblies 24, and the plurality of plug valve chuck assemblies 24 are arranged in the aliquoting housing 21 and are spaced apart along the width direction of the aliquoting housing 21. The distance between adjacent two plug valve chuck assemblies 24 is equal. The plug valve chuck assembly 24 is used to drive the plug valve 44 of the consumable 4 to switch channels. The number of the plug valve chuck assemblies 24 is the same as the number of the plug valves 44, and the positions of the plug valve chuck assemblies 24 correspond to the positions of the plug valves 44 one by one.

[0100] In an embodiment of the present utility model, as Figure 2 and Figure 4 shown, the plug valve chuck assembly 24 includes a plug valve chuck 240, a rotating shaft 241 and a first driving mechanism 242. The plug valve chuck 240 is located outside the aliquoting housing 21, and the plug valve chuck 240 is used to clamp and rotate the plug valve 44. The end of the plug valve chuck 240 is provided with a plug valve positioning groove, and the plug valve positioning groove is in snap-fit with the plug valve 44. The shape of the plug valve positioning groove is adapted to the shape of the plug valve 44. In this embodiment, the cross-section of the plug valve positioning groove is in a T shape. Of course, the cross-sectional shape of the plug valve positioning groove is not limited thereto, and is specifically determined according to the shape of the plug valve 44. By adopting the snap-fit mode of the plug valve chuck 240 and the plug valve 44, the installation of the consumable 4 can be facilitated.

[0101] The rotating shaft 241 is horizontally arranged and is used to connect the first driving mechanism 242 and the plug valve 44. The dispensing housing 21 is provided with a mounting hole, and the first end of the rotating shaft 241 passes through the mounting hole and is then connected to the plug valve chuck 240. The rotating shaft 241 and the plug valve chuck 240 can be connected by welding, integrally formed, or connected by threads. Preferably, the rotating shaft 241 and the plug valve chuck 240 are integrally formed.

[0102] The first driving mechanism 242 is connected to the dispensing housing 21 through the motor mounting plate 257. Specifically, the first driving mechanism 242 is connected to the motor mounting plate 257 by screws, and the motor mounting plate 257 is connected to the side wall of the dispensing housing 21 by screws.

[0103] The rotating shaft of the first driving mechanism 242 is connected to the second end of the rotating shaft 241. The first driving mechanism 242 is used to drive the plug valve chuck 240 to rotate so as to switch the channels of the plug valve 44. The first driving mechanism 242 is a servo motor, and the first driving mechanism 242 is electrically connected to the second circuit board, and the second circuit board controls the rotation of the first driving mechanism 242.

[0104] In an embodiment of the present invention, the plug valve chuck assembly 24 further includes a home position sensing mechanism and a first sensor mechanism. The home position sensing mechanism includes a second sensor 245 and a home position sensing piece 246. The home position sensing piece 246 is sleeved on the outer periphery of the rotating shaft 241 and is located between the angular position sensing piece 244 and the plug valve chuck 240. The home position sensing piece 246 is coaxially arranged with the rotating shaft 241. A second notch is provided at the edge of the home position sensing piece 246. The second sensor 245 is connected to the motor mounting plate 257, and the second sensor 245 is used to detect whether the home position sensing piece 246 is in the initial position. The second sensor 245 is electrically connected to the second circuit board, and the type of the second sensor 245 is the same as that of the first sensor 243. When the second notch of the home position sensing piece 246 rotates to align with the second sensor 245, the second sensor 245 outputs an electrical signal to the second circuit board, indicating that the home position sensing piece 246 rotates to the initial position.

[0105] The first sensor mechanism includes a first sensor 243 and an angular position sensing piece 244. The angular position sensing piece 244 is sleeved on the outer periphery of the rotating shaft 241. Preferably, a snap ring 249 is sleeved on the outer periphery of the rotating shaft 241. The snap ring 249 is located on the side of the angular position sensing piece 244 away from the cock chuck 240. The snap ring 249 abuts against the angular position sensing piece 244, and the snap ring 249 is used to limit the angular position sensing piece 244. A plurality of first notches are arranged at intervals on the edge of the angular position sensing piece 244, and the plurality of first notches are arranged at equal intervals in the circumferential direction. The first sensor 243 is connected to the motor mounting plate 257, and the first sensor 243 is used to detect the angle of rotation of the angular position sensing piece 244. The first sensor 243 is a photoelectric sensor, and the first sensor 243 is electrically connected to the second circuit board.

[0106] When the angular position sensing piece 244 rotates until the first notch is aligned with the first sensor 243, the light beam emitted by the output end of the first sensor 243 passes through the first notch and is received by the receiving end of the first sensor 243. The first sensor 243 outputs an electrical signal to the second circuit board, indicating that the angular position sensing piece 244 rotates a predetermined angle. Since the distances between adjacent two first notches are equal, the second circuit board can calculate the rotation angle of the angular position sensing piece 244 according to the number of electrical signals received.

[0107] It should be noted here that the more the number of first notches, the higher the detection accuracy of the first sensor 243. The specific number of first notches is determined according to actual needs. The specific structural form of the first notch is not limited to the notch, and through holes can also be used to replace the first notch.

[0108] In an embodiment of the present invention, as Figure 5 and Figure 10 shown, the cell dispensing device 2 further includes an industrial camera 270 and a bubble sensor group 271. The industrial camera 270 and the bubble sensor group 271 are arranged on one side of the dispensing housing 21. The bubble sensor group 271 includes a plurality of first bubble sensors, and the plurality of first bubble sensors are arranged at intervals in the width direction of the dispensing housing 21. The positions of the first bubble sensors correspond one-to-one to the positions of the liquid path hoses 42 on the consumable 4, and the first bubble sensors are used to detect whether there are bubbles in the liquid path hoses 42. The industrial camera 270 is located above the bubble sensor group 271, and the industrial camera 270 is used to detect whether there are bubbles in the liquid path hoses 42. The liquid path hoses 42 are connected to the preparation bags. During use, the liquid path hoses 42 are in a vertical state, the liquid path hoses 42 are stretched, and the outer diameter of the liquid path hoses 42 decreases, reducing the frictional resistance of the liquid path hoses 42 being stuck into the first bubble sensors, realizing the rapid installation of the hoses.

[0109] In an embodiment of the present invention, Figure 2As shown, the cell dispensing device 2 further includes a second bubble sensor 272. The second bubble sensor 272 is disposed on one side of the dispensing housing 21 and is electrically connected to the second circuit board. The second bubble sensor 272 is used to detect whether there are bubbles in the input tube of the consumable 4.

[0110] In an embodiment of the present invention, a cell dispensing module alarm lamp 273, a consumable installation confirmation key 274, and a cell dispensing module power key 275 are further disposed on one side of the dispensing housing 21. The cell dispensing module alarm lamp 273, the consumable installation confirmation key 274, and the cell dispensing module power key 275 are all electrically connected to the second circuit board. The cell dispensing module alarm lamp 273 is used to flash when the cell dispensing device 2 has an abnormality to remind the operator to intervene in time. The consumable installation confirmation key 274 is used to control the plug valve chuck assembly 24, the syringe support plate 221, and the syringe clamping plate 222 to return to their initial positions when installing the consumable 4 to facilitate the installation of the consumable 4. The cell dispensing module power key 275 is used to control the cell dispensing device 2 to be turned on or off.

[0111] In an embodiment of the present invention, as Figure 11 shown, the cell constant temperature shaking device 1 includes a shaking housing 11, a first circuit board, a constant temperature component 12, a shaking component 13, and a heat preservation opening and closing door 14. An opening is provided on one side of the shaking housing 11. The first circuit board is disposed inside the shaking housing 11 and is electrically connected to the corresponding connection ports; the constant temperature component 12 is disposed inside the shaking housing 11. The constant temperature component 12 is electrically connected to the first circuit board. The constant temperature component 12 is used to control the temperature inside the shaking housing 11 so that the cell preparation bag is in a predetermined constant temperature environment. The shaking component 13 is disposed inside the shaking housing 11. The shaking component 13 is electrically connected to the first circuit board. The shaking component 13 is used to uniformly mix the cell liquid in the cell preparation bag at a predetermined temperature. The heat preservation opening and closing door 14 is disposed at the opening of the shaking housing 11. The heat preservation opening and closing door 14 is provided with glass 15. Preferably, the heat preservation opening and closing door 14 is provided with double-layer glass. By using double-layer glass, the constant temperature ability inside the shaking housing 11 is enhanced, power loss is reduced, and the generation of condensed water is reduced.

[0112] In an embodiment of the present invention, as Figure 12 shown, the control device 3 includes a housing 31, a main control circuit board, and a display screen 32. The main control circuit board is disposed inside the housing 31 and is electrically connected to a plurality of connection ports; the display screen 32 is connected to the housing 31 through a movable arm 33. By using the movable arm 33 to fix the display screen 32, the angle of the display screen 32 can be adjusted as needed, making it more convenient to use. The display screen 32 is electrically connected to the main control circuit board. The display screen 32 is used to display the working parameters of the cell dispensing device 2 and the working parameters of the cell constant temperature shaking device 1.

[0113] In an embodiment of the present utility model, a control and operation module power key 34, a control and operation module alarm light 35, and a data cable interface 36 are provided on one side of the outer housing 31. The control and operation module power key 34, the control and operation module alarm light 35, and the data cable interface 36 are all electrically connected to the main control circuit board. The control and operation module power key 34 is used to control the opening and closing of the control device 3. The control and operation module alarm light 35 is used to give an alarm when the main control circuit board detects an abnormality, reminding the operator to intervene in time. The data cable interface 36 is used to connect to an external interface. Preferably, the data cable interface 36 is a USB interface.

[0114] In an embodiment of the present utility model, a speaker is further provided on one side of the outer housing 31. The speaker is electrically connected to the main control circuit board. The speaker is used to play the voice information output by the main control circuit board.

[0115] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present utility model and are not intended to limit them. Although the present utility model has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the various embodiments of the present utility model.

Claims

1. A multifunctional cell automatic precision dispensing device, characterized in that, Comprising: A control device (3), the control device (3) being provided with a plurality of connection ports; A cell constant temperature shaking device (1), the cell constant temperature shaking device (1) being used for uniformly mixing the cell liquid in the cell preparation bag at a predetermined temperature; At least one cell dispensing device (2), both the cell dispensing device (2) and the cell constant temperature shaking device (1) being electrically connected to the corresponding connection ports.

2. The multifunctional cell automatic precision dispensing device according to claim 1, characterized in that, The cell dispensing device (2) includes: A dispensing housing (21); A stopcock valve chuck component, including a plurality of stopcock valve chuck assemblies (24), the plurality of stopcock valve chuck assemblies (24) being arranged on the dispensing housing (21) and spaced along the width direction of the dispensing housing (21), the stopcock valve chuck assembly (24) being used for driving the stopcock valve (44) of the consumable (4) to switch channels.

3. The multifunctional cell automatic precision dispensing device according to claim 2, characterized in that, The stopcock valve chuck assembly (24) includes: A stopcock valve chuck (240), the stopcock valve chuck (240) being located outside the dispensing housing (21), the stopcock valve chuck (240) being used for clamping and rotating the stopcock valve (44); A rotating shaft (241), the dispensing housing (21) being provided with a mounting hole, a first end of the rotating shaft (241) passing through the mounting hole and then being connected to the stopcock valve chuck (240); A first driving mechanism (242), the first driving mechanism (242) being connected to the dispensing housing (21) through a motor mounting plate (257), a rotating shaft of the first driving mechanism (242) being connected to a second end of the rotating shaft (241), the first driving mechanism (242) being used for driving the stopcock valve chuck (240) to rotate so as to switch the channels of the stopcock valve (44).

4. The multifunctional cell automatic precision dispensing device according to claim 3, wherein The stopcock valve chuck assembly (24) further includes: A first sensor mechanism, including a first sensor (243) and an angular position sensing piece (244), the angular position sensing piece (244) being sleeved on the outer periphery of the rotating shaft (241), a plurality of first notches being spaced at the edge of the angular position sensing piece (244); the first sensor (243) being connected to the motor mounting plate (257), the first sensor (243) being used for detecting the rotation angle of the angular position sensing piece (244). A home position sensing mechanism, including a second sensor (245) and a home position sensing piece (246), the home position sensing piece (246) being sleeved on the outer periphery of the rotating shaft (241) and located between the angular position sensing piece (244) and the stopcock valve chuck (240), the second sensor (245) being connected to the motor mounting plate (257), the second sensor (245) being used for detecting whether the home position sensing piece (246) is in the initial position.

5. The multifunctional cell automatic precision dispensing device according to any one of claims 2 to 4, characterized in that, The cell dispensing device (2) further includes: A fixing device, the fixing device including at least one positioning member (25), the positioning member (25) including two positioning blocks (250), the two positioning blocks (250) being spaced along the width direction of the dispensing housing (21), the positioning blocks (250) being in positioning cooperation with the clamping plate (41) of the consumable (4).

6. The multifunctional cell automatic precision dispensing device according to claim 5, wherein The positioning component (25) further includes: At least one locking assembly, including an elastic buckle (251), an elastic member (252), and a limiting member (253). The limiting member (253) and the elastic buckle (251) are oppositely arranged on the positioning block (250). The elastic buckle (251) is rotatably matched with the positioning block (250) through a pin shaft. The elastic member (252) is arranged between the elastic buckle (251) and the limiting member (253). The elastic buckle (251) is used to lock the clamping plate (41).

7. The multifunctional cell automatic precision dispensing device according to claim 5, characterized in that, The positioning component (25) further includes: A positioning member, arranged on the positioning block (250). A positioning hole is arranged on the side of the clamping plate (41). The positioning member is in positioning cooperation with the positioning hole.

8. The multifunctional cell automatic precision dispensing device according to claim 7, wherein The positioning component (25) further includes: A third sensor (254), arranged on the positioning block (250). The third sensor (254) is used to detect whether the clamping plate (41) is installed in place.

9. The multifunctional cell automatic precision dispensing device according to any one of claims 1 to 4, characterized in that The cell constant temperature shaking device (1) includes: A shaking housing (11), with an opening arranged on one side of the shaking housing (11); A first circuit board, arranged inside the shaking housing (11) and electrically connected to the corresponding connection ports; A constant temperature component (12), arranged inside the shaking housing (11). The constant temperature component (12) is electrically connected to the first circuit board. The constant temperature component (12) is used to control the temperature inside the shaking housing (11); A shaking component (13), arranged inside the shaking housing (11). The shaking component (13) is electrically connected to the first circuit board. The shaking component (13) is used to uniformly mix the cell liquid in the cell preparation bag at a predetermined temperature; A heat preservation opening and closing door (14), arranged at the opening of the shaking housing (11).

10. The multifunctional cell automatic precision dispensing device according to any one of claims 1 to 4, characterized in that The control device (3) includes: A housing body (31); A main control circuit board, arranged inside the housing body (31). The main control circuit board is electrically connected to multiple connection ports; A display screen (32), the display screen (32) is connected to the housing body (31) through a movable arm (33). The display screen (32) is electrically connected to the main control circuit board.

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