Automatic stirring device for pharmaceutical chromatographic column

Abstract

The utility model relates to the field of chromatographic columns, and discloses an automatic stirring device for a pharmaceutical chromatographic column, which comprises a supporting plate, a supporting column is fixedly connected to the bottom of the supporting plate, a column casing is fixedly connected to the inner wall of the supporting plate, a stirring mechanism is arranged in the column casing, a stirring cylinder is fixedly connected to the inner wall of the supporting plate, and the stirring mechanism is arranged in the stirring cylinder. The top of the stirring barrel is fixedly connected with a liquid inlet pipe, the top of the stirring barrel is provided with a driving mechanism, the driving mechanism comprises a fixing column, the fixing column is fixedly installed at the top of the supporting plate, and the top of the fixing column is fixedly connected with a stepping motor. According to the utility model, the pretreatment mechanism is arranged, and the stepping motor works to drive the push plate to move up and down, so that the liquid medicine on the inner wall of the stirring barrel is scraped off, the amount of the liquid medicine adhered to the inner wall of the stirring barrel is reduced, the liquid medicine is pushed into the column barrel to carry out the next process, the waste of the liquid medicine is reduced, and the economic benefit is improved.

Description

Technical Field

[0001] The utility model relates to the field of chromatography columns, in particular to an automatic stirring device for pharmaceutical chromatography columns. Background Art

[0002] Chromatography columns are suitable for molecular sieve, ion exchange, gel permeation and affinity chromatography, and are also good chromatography tools for laboratories such as biochemistry, petrochemical industry, chemical analysis, disease diagnosis, and pilot and large-scale production of medical pharmaceuticals. Stirring during the chromatography process of the liquid medicine can improve the mixing uniformity of the liquid medicine in the chromatography column, and thus optimize the efficiency of processes such as drug separation and purification.

[0003] In the prior art, generally before mixing and stirring the liquid medicine and chromatography mother liquor, the liquid medicine will be preliminarily mixed evenly to stir the packing, which is convenient for subsequent purification work of the liquid medicine. However, after pretreatment, part of the liquid medicine will adhere to the inner wall of the stirring tank, resulting in waste of part of the liquid medicine, thus reducing the economic benefit. Therefore, an automatic stirring device for pharmaceutical chromatography columns is proposed to solve the above problems. Summary of the Utility Model

[0004] To make up for the above deficiencies, the utility model provides an automatic stirring device for pharmaceutical chromatography columns, aiming to improve the problem that "part of the liquid medicine will adhere to the inner wall of the stirring tank, resulting in waste of part of the liquid medicine" in the prior art.

[0005] To achieve the above purpose, the utility model adopts the following technical scheme: an automatic stirring device for pharmaceutical chromatography columns, including a support plate, a support column is fixedly connected to the bottom of the support plate, a column barrel is fixedly connected to the inner wall of the support plate, a stirring mechanism is arranged inside the column barrel, a stirring barrel is fixedly connected to the inner wall of the support plate, a liquid inlet pipe is fixedly connected to the top of the stirring barrel, a driving mechanism is arranged at the top of the stirring barrel, the driving mechanism includes a fixed column, the fixed column is fixedly installed on the top of the support plate, a stepping motor is fixedly connected to the top of the fixed column, a circular plate is fixedly connected to the front end of the output shaft of the stepping motor, a connecting rod is hinged to the front surface of the circular plate, a sliding rod is hinged to the end of the connecting rod away from the circular plate, the sliding rod is slidably installed on the inner wall of the stirring barrel, a spiral convex block is arranged on the middle surface of the sliding rod, and a pretreatment mechanism is arranged outside the sliding rod, and the pretreatment mechanism includes a stirrer one, a push plate and an electromagnetic valve.

[0006] As a further description of the above technical solution:

[0007] A groove is arranged on the inner wall of the stirrer one, the stirrer one is slidably installed on the surface of the spiral convex block, and the stirrer one is rotatably installed on the inner wall of the stirring barrel.

[0008] As a further description of the above technical solution:

[0009] The push plate is fixedly installed at the bottom of the sliding rod. The push plate is slidably installed on the inner wall of the mixing cylinder. The solenoid valve is fixedly installed on the inner wall of the push plate.

[0010] As a further description of the above technical solution:

[0011] The column cylinder and the mixing cylinder are connected by a delivery pipe. A flow meter is arranged at the top of the delivery pipe.

[0012] As a further description of the above technical solution:

[0013] The inside of the column cylinder communicates with the inside of the mixing cylinder.

[0014] As a further description of the above technical solution:

[0015] The liquid inlet pipe is arranged on the right side at the top of the mixing cylinder. The connecting rod is hinged at a non-central position of the circular plate.

[0016] As a further description of the above technical solution:

[0017] The mixing mechanism includes a servo motor. The servo motor is fixedly installed at the top of the column cylinder. The bottom of the output shaft of the servo motor is fixedly connected with a rotating shaft. The rotating shaft passes through and is rotatably installed on the inner wall of the column cylinder. The bottom of the rotating shaft is fixedly connected with a stirrer II.

[0018] As a further description of the above technical solution:

[0019] The left side of the column cylinder is fixedly connected with a liquid outlet pipe. The top of the column cylinder is fixedly connected with a feed pipe.

[0020] The utility model has the following beneficial effects:

[0021] 1. In the utility model, by arranging a pretreatment mechanism, when the stepping motor works, it will drive the push plate to move up and down, thereby scraping off the liquid medicine on the inner wall of the mixing cylinder, reducing the amount of liquid medicine adhering to the inner wall of the mixing cylinder, and then pushing the liquid medicine into the column cylinder for the next process, reducing the waste of liquid medicine and improving the economic benefit.

[0022] 2. In the utility model, by arranging a mixing mechanism, the mixed liquid of the chromatography mother liquor and the liquid medicine inside the column cylinder is stirred and mixed, increasing the contact area between the chromatography mother liquor and the liquid medicine, and then increasing the reaction rate between the chromatography mother liquor and the liquid medicine. Through the raised block arranged on the top of the push plate, the movement of the push plate squeezes and oscillates the liquid medicine inside the mixing cylinder, further improving the uniformity of the raw material mixing. Description of the Drawings

[0023] Figure 1 It is a schematic three-dimensional structure diagram of the whole in the utility model;

[0024] Figure 2 This is a schematic cross-sectional view of the three-dimensional structure of the driving mechanism and the pretreatment mechanism in the present utility model;

[0025] Figure 3 This is a schematic three-dimensional exploded view of the pretreatment mechanism in the present utility model;

[0026] Figure 4 This is a schematic three-dimensional structure view of the stirring mechanism in the present utility model.

[0027] Legend:

[0028] 1. Support plate; 2. Support column; 3. Column barrel; 4. Stirring barrel; 5. Liquid inlet pipe; 6. Fixed column; 7. Stepper motor; 8. Circular plate; 9. Connecting rod; 10. Slide bar; 11. Spiral convex block; 12. Stirrer 1; 13. Pushing plate; 14. Solenoid valve; 15. Servo motor; 16. Rotating shaft; 17. Stirrer 2; 18. Liquid outlet pipe; 19. Feed pipe; 20. Flowmeter. Detailed implementation manners

[0029] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts shall fall within the protection scope of the present utility model.

[0030] Refer to Figure 1 , an embodiment provided by the present utility model: An automatic stirring device for a pharmaceutical chromatography column, including a support plate 1, a support column 2 for supporting is fixedly connected to the bottom of the support plate 1 to improve the stability of the equipment during operation, a column barrel 3 for performing chromatography work is fixedly connected to the inner wall of the support plate 1, a stirring mechanism is arranged inside the column barrel 3, a stirring barrel 4 for preliminarily treating the liquid medicine is fixedly connected to the inner wall of the support plate 1, the column barrel 3 and the stirring barrel 4 are connected through a conveying pipe, a flowmeter 20 for conveniently reading the flow rate entering the inside of the column barrel 3 is arranged at the top of the conveying pipe, which improves the accuracy of liquid medicine volume control and further improves the quality of chromatography work, the inside of the column barrel 3 and the inside of the stirring barrel 4 are communicated, and a driving mechanism is arranged at the top of the stirring barrel 4.

[0031] Refer to Figure 1 - Figure 3, the driving mechanism includes a fixed column 6 that plays a stabilizing and supporting role. The fixed column 6 is fixedly installed on the top of the support plate 1. The top of the fixed column 6 is fixedly connected to a stepping motor 7. The stepping motor 7 can accurately control the rotation angle of its output shaft, improving the control accuracy. The front end of the output shaft of the stepping motor 7 is fixedly connected to a circular plate 8. The front surface of the circular plate 8 is hinged with a connecting rod 9. The connecting rod 9 is hinged at a non-central position of the circular plate 8. When the circular plate 8 rotates, the end of the connecting rod 9 close to the circular plate 8 will rotate synchronously around the center of the circular plate 8. The end of the connecting rod 9 far from the circular plate 8 is hinged with a sliding rod 10. The sliding rod 10 is slidably installed on the inner wall of the mixing cylinder 4. The sliding direction of the sliding rod 10 is up and down. A spiral convex block 11 is arranged on the middle surface of the sliding rod 10. A pretreatment mechanism is arranged outside the sliding rod 10. The pretreatment mechanism includes a first stirrer 12, a push plate 13, and a solenoid valve 14.

[0032] Refer to Figure 2 , Figure 3 , a groove matching with the spiral convex block 11 is arranged on the inner wall of the first stirrer 12. The first stirrer 12 is slidably installed on the surface of the spiral convex block 11. The first stirrer 12 is rotatably installed on the inner wall of the mixing cylinder 4. When the sliding rod 10 moves up and down, the first stirrer 12 rotates through the action of thread conversion. The push plate 13 is fixedly installed at the bottom of the sliding rod 10. A raised block is arranged on the top of the push plate 13, which can play a role in pushing and mixing the liquid medicine inside the mixing cylinder 4, and further improve the mixing effect in cooperation with the rotation of the first stirrer 12. The push plate 13 is slidably installed on the inner wall of the mixing cylinder 4. The solenoid valve 14 is fixedly installed on the inner wall of the push plate 13. The solenoid valve 14 is initially in a closed state. The opening and closing of the solenoid valve 14 can control the connection or disconnection between the inside of the mixing cylinder 4 and the inside of the column cylinder 3.

[0033] Refer to Figure 4 , the mixing mechanism includes a servo motor 15. The servo motor 15 can accurately control the rotation angle of its output shaft, and the control accuracy is high. The servo motor 15 is fixedly installed on the top of the column cylinder 3. The bottom of the output shaft of the servo motor 15 is fixedly connected to a vertical rotating shaft 16. The rotating shaft 16 passes through and is rotatably installed on the inner wall of the column cylinder 3. The bottom of the rotating shaft 16 is fixedly connected to a second stirrer 17, realizing the automatic operation of the mixing process and reducing the labor intensity of the operator.

[0034] Refer to Figure 1 , Figure 4 , the top of the mixing cylinder 4 is fixedly connected to a liquid inlet pipe 5 for injecting liquid medicine into the mixing cylinder 4. The liquid inlet pipe 5 is arranged on the right side of the top of the mixing cylinder 4. The left side of the column cylinder 3 is fixedly connected to a liquid outlet pipe 18 for discharging the liquid inside the column cylinder 3. The top of the column cylinder 3 is fixedly connected to a feed pipe 19 for injecting chromatography mother liquor into the mixing cylinder 4, facilitating the reaction between the chromatography mother liquor and the liquid medicine.

[0035] Working principle: When in use, the liquid medicine is input into the interior of the stirring cylinder 4 through the liquid inlet pipe 5. Then, the power supply of the stepping motor 7 is started. The stepping motor 7 works to drive the circular plate 8 to rotate. The rotation of the circular plate 8 drives the connecting rod 9 to move. The movement of the connecting rod 9 drives the sliding rod 10 to perform linear reciprocating motion in the vertical direction. The movement of the sliding rod 10 drives the spiral convex block 11 on the surface of the middle part of the sliding rod 10 to perform linear reciprocating motion, thereby driving the stirrer one 12 to rotate reciprocally, so as to stir the liquid medicine in the stirring cylinder 4 evenly, which helps to improve the efficiency and quality of drug separation and purification.

[0036] The movement of the sliding rod 10 will also drive the push plate 13 to perform linear reciprocating motion in the vertical direction. The movement of the push plate 13 pushes and oscillates the liquid medicine in the inner stirring cylinder 4, further improving the evenness of the liquid medicine stirring. When the liquid medicine is mixed to a relatively even degree, the electromagnetic valve 14 is changed to the open state, and the liquid medicine in the stirring cylinder 4 will enter the interior of the column cylinder 3. At the same time, the push plate 13 continues to perform linear reciprocating motion to scrape off the liquid medicine adhering to the inner wall of the column cylinder 3, reducing the waste of the liquid medicine.

[0037] The chromatography mother liquor is put into the column cylinder 3 through the feed pipe 19. Then, the power supply of the servo motor 15 is started. The servo motor 15 works to drive the rotating shaft 16 to rotate. The rotation of the rotating shaft 16 drives the stirrer two 17 to rotate. The rotation of the stirrer two 17 stirs and mixes the mixed liquid of the chromatography mother liquor and the liquid medicine in the column cylinder 3, increasing the contact area between the chromatography mother liquor and the liquid medicine, and increasing the reaction rate between the chromatography mother liquor and the liquid medicine.

[0038] Finally, it should be noted that the above are only the preferred embodiments of the present invention and are not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. An automatic stirring device for a pharmaceutical chromatography column, comprising a support plate (1), characterized in that: The bottom of the support plate (1) is fixedly connected with support columns (2). A column cylinder (3) is fixedly connected to the inner wall of the support plate (1). A stirring mechanism is arranged inside the column cylinder (3). A stirring cylinder (4) is fixedly connected to the inner wall of the support plate (1). A liquid inlet pipe (5) is fixedly connected to the top of the stirring cylinder (4). A driving mechanism is arranged at the top of the stirring cylinder (4). The driving mechanism includes a fixed column (6). The fixed column (6) is fixedly installed on the top of the support plate (1). A stepping motor (7) is fixedly connected to the top of the fixed column (6). The front end of the output shaft of the stepping motor (7) is fixedly connected with a circular plate (8). A connecting rod (9) is hinged to the front surface of the circular plate (8). One end of the connecting rod (9) away from the circular plate (8) is hinged to a sliding rod (10). The sliding rod (10) is slidably installed on the inner wall of the stirring cylinder (4). A spiral convex block (11) is arranged on the middle surface of the sliding rod (10). A pretreatment mechanism is arranged outside the sliding rod (10). The pretreatment mechanism includes a stirrer one (12), a push plate (13) and a solenoid valve (14).

2. The automatic stirring device for a pharmaceutical chromatography column according to claim 1, wherein: A groove is arranged on the inner wall of the stirrer one (12). The stirrer one (12) is slidably installed on the surface of the spiral convex block (11). The stirrer one (12) is rotatably installed on the inner wall of the stirring cylinder (4).

3. The automatic stirring device for a pharmaceutical chromatography column according to claim 1, characterized in that: The push plate (13) is fixedly installed at the bottom of the sliding rod (10). The push plate (13) is slidably installed on the inner wall of the stirring cylinder (4). The solenoid valve (14) is fixedly installed on the inner wall of the push plate (13).

4. The automatic stirring device for a pharmaceutical chromatography column according to claim 1, wherein: The column cylinder (3) and the stirring cylinder (4) are connected through a delivery pipe. A flowmeter (20) is arranged at the top of the delivery pipe.

5. The automatic stirring device for a pharmaceutical chromatography column according to claim 4, wherein: The inside of the column cylinder (3) is communicated with the inside of the stirring cylinder (4).

6. The automatic stirring device for a pharmaceutical chromatography column according to claim 1, characterized in that: The liquid inlet pipe (5) is arranged on the right side of the top of the stirring cylinder (4). The connecting rod (9) is hinged at a non - center position of the circular plate (8).

7. An automatic stirring device for a pharmaceutical chromatography column according to claim 1, characterized in that: The stirring mechanism includes a servo motor (15). The servo motor (15) is fixedly installed on the top of the column cylinder (3). The bottom of the output shaft of the servo motor (15) is fixedly connected with a rotating shaft (16). The rotating shaft (16) passes through and is rotatably installed on the inner wall of the column cylinder (3). The bottom of the rotating shaft (16) is fixedly connected with a stirrer two (17).

8. The automatic stirring device for a pharmaceutical chromatography column according to claim 1, wherein: An outlet pipe (18) is fixedly connected to the left side of the column cylinder (3). A feed pipe (19) is fixedly connected to the top of the column cylinder (3).

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