Molecular diagnosis sample concentration device

Abstract

The utility model discloses a molecular diagnosis sample concentration device which comprises a concentration mechanism, a sample storage mechanism is arranged in the concentration mechanism, the concentration mechanism comprises a concentration chamber, a plurality of nitrogen nozzles are installed on the surface of the concentration chamber, and the gas outlet ends of the nitrogen nozzles penetrate into an inner cavity of the concentration chamber. The gas inlet end of the nitrogen nozzle is communicated with a flow adjusting valve, the gas inlet end of the flow adjusting valve is communicated with an annular pipe, the surface of the annular pipe is communicated with a conveying pipe, and the gas inlet end of the conveying pipe is communicated with an electromagnetic valve. The molecular diagnosis sample concentration device has the advantage of high efficiency, and solves the problems that when an existing molecular diagnosis sample concentration device uses nitrogen to concentrate a sample, the sample concentration efficiency is low, a user needs to spend more time to complete the concentration process, the experimental period is prolonged, and the working efficiency is influenced.

Description

Technical Field

[0001] The utility model relates to the technical field of molecular diagnosis, and particularly relates to a molecular diagnosis sample concentration device. Background Art

[0002] A molecular diagnosis sample concentration device is a device used to reduce the sample volume while maintaining or enriching the concentration of the target analyte. Such devices are very important in the molecular diagnosis process because they can help improve the sensitivity and specificity of detection. By concentration, the concentration of target molecules (such as DNA and RNA) in the sample can be increased, thereby improving the sensitivity of the detection method and enabling the detection of target molecules even at low concentrations. The sample often contains a large number of non-target molecules, and these non-target molecules may interfere with the detection results. Concentration can reduce the proportion of these non-target molecules, reduce background noise, and improve the specificity of detection.

[0003] The sample concentration method includes nitrogen blowing concentration. Nitrogen blowing concentration is to gently blow the nitrogen gas flow on the surface of the sample to evaporate the solvent and concentrate the biomolecules in the sample. Nitrogen is an inert gas and will not react with other substances in chemical reactions. The nitrogen blowing concentration device blows nitrogen gas at a stable flow rate towards the liquid surface of the sample through a fine nozzle, which helps to evenly disperse the nitrogen gas flow and avoid violent fluctuations of the sample. The blowing of the nitrogen gas flow will prompt the rapid evaporation of the solvent on the surface of the sample. Since nitrogen does not participate in chemical reactions, it only serves as a carrier to assist the evaporation process, so it will not affect the biomolecules in the sample. In addition, the blowing of nitrogen can also help control the evaporation rate and avoid sample loss caused by too fast evaporation. The goal of nitrogen blowing concentration is to concentrate the biomolecules in the sample. These biomolecules are much larger than the solvent molecules and are usually non-volatile at room temperature, so they will not be carried away by the nitrogen gas together with the solvent. The nitrogen blowing concentration device is usually connected to the ventilation system of the laboratory. In this way, the exhausted nitrogen gas will be drawn away and discharged to the outside through the ventilation duct. This method helps to maintain the air quality in the laboratory and ensure the safety of the operators.

[0004] When the existing molecular diagnosis sample concentration device uses nitrogen to concentrate the sample, the concentration efficiency of the sample is relatively low, and it requires the user to spend more time to complete the concentration process, which will increase the experimental cycle and affect the work efficiency. Summary of the Utility Model

[0005] The purpose of the utility model is to provide a molecular diagnosis sample concentration device, which has the advantage of high efficiency, and solves the problem that when the existing molecular diagnosis sample concentration device uses nitrogen to concentrate the sample, the concentration efficiency of the sample is relatively low, and it requires the user to spend more time to complete the concentration process, which will increase the experimental cycle and affect the work efficiency.

[0006] To achieve the above object, the present utility model provides the following technical solution: A molecular diagnostic sample concentration device, comprising a concentration mechanism, wherein a sample storage mechanism is arranged inside the concentration mechanism,

[0007] The concentration mechanism includes a concentration chamber, and a plurality of nitrogen nozzles are installed on the surface of the concentration chamber. The air outlet end of the nitrogen nozzle penetrates into the inner cavity of the concentration chamber, and the air inlet end of the nitrogen nozzle is communicated with a flow regulating valve. The air inlet end of the flow regulating valve is communicated with an annular pipe, and a conveying pipe is communicated with the surface of the annular pipe. The air inlet end of the conveying pipe is communicated with a solenoid valve;

[0008] The sample storage mechanism includes a lifting platform, and a sample tank is movably connected to the top of the lifting platform. The sample tank is located inside the concentration chamber and is slidably connected to its inner wall. The top of the sample tank is located at the bottom of the air outlet end of the nitrogen nozzle.

[0009] As a preferred embodiment of the molecular diagnostic sample concentration device of the present utility model, a connecting flange is fixedly connected to the top of the concentration chamber, and the connecting flange is connected to a ventilation system.

[0010] As a preferred embodiment of the molecular diagnostic sample concentration device of the present utility model, an electric heating ring is fixedly connected to the bottom of the concentration chamber, and the electric heating ring is movably sleeved on the surface of the sample tank.

[0011] As a preferred embodiment of the molecular diagnostic sample concentration device of the present utility model, a temperature sensor is fixedly installed on the inner wall of the concentration chamber, and the detection end of the temperature sensor extends into the inner cavity of the sample tank.

[0012] As a preferred embodiment of the molecular diagnostic sample concentration device of the present utility model, positioning pins are fixedly connected to the four corners of the bottom of the sample tank, and the positioning pins penetrate to the bottom of the lifting platform and are movably connected thereto.

[0013] As a preferred embodiment of the molecular diagnostic sample concentration device of the present utility model, limiting rods are fixedly connected to both the left and right sides of the top of the lifting platform, and the tops of the limiting rods are movably connected to the bottom of the concentration chamber.

[0014] As a preferred embodiment of the molecular diagnostic sample concentration device of the present utility model, electric telescopic rods are fixedly connected to both the left and right sides of the bottom of the lifting platform. A support platform is fixedly connected to the bottom of the electric telescopic rod. A support rod is fixedly connected to the surface of the concentration chamber, and a base is fixedly connected to the bottom of the support rod. The bottom of the support platform is fixedly connected to the top of the base, and a controller is fixedly installed on the top of the base.

[0015] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0016] 1. When the present utility model concentrates a sample, the solenoid valve is opened, and nitrogen gas enters from the delivery pipe. The nitrogen gas flows through the annular pipe and then enters the flow regulating valve. The flow of nitrogen gas is controlled by the flow regulating valve. Finally, it is blown onto the sample in the sample tank through the nitrogen gas nozzle, accelerating the evaporation of the solvent, thereby achieving the purpose of concentration. During the nitrogen blowing process, the electric heating ring heats the liquid in the sample tank to improve the evaporation efficiency. The temperature sensor monitors the temperature inside the sample tank and feeds it back to the controller to ensure that the concentration process is carried out at an appropriate temperature. The connecting flange is connected to the ventilation system for discharging the steam and waste gas generated during the concentration process.

[0017] 2. The present utility model evenly distributes the nitrogen gas nozzles around the concentration chamber to ensure that nitrogen gas can effectively blow onto the sample in the sample tank, accelerating the evaporation of the solvent. The flow regulating valve can precisely control the nitrogen gas flow to meet the requirements of different sample volumes. The electric heating ring surrounds the sample tank, which can evenly heat the sample tank and improve the evaporation efficiency. The temperature sensor monitors the temperature inside the sample tank to ensure that the heating process is carried out within an appropriate temperature range, avoiding overheating and damaging the sample. The controller can automatically adjust the heating power and nitrogen gas flow according to the data fed back by the temperature sensor to ensure that the concentration process is efficient and safe. The lifting platform moves up and down through the electric telescopic rod, facilitating the loading and unloading of the sample tank. The positioning pin and the limiting rod ensure that the sample tank is accurately positioned and stable during the concentration process. By significantly shortening the concentration time, the working efficiency of the laboratory is improved. The efficient concentration process reduces energy consumption and operating costs. Description of the Drawings

[0018] Figure 1 is the front isometric view of the present utility model;

[0019] Figure 2 is the front sectional isometric view of the present utility model;

[0020] Figure 3 is the front partial sectional view of the concentration mechanism of the present utility model;

[0021] Figure 4 is the front isometric view of the sample storage mechanism of the present utility model;

[0022] Figure 5 is the bottom isometric view of the sample storage mechanism of the present utility model.

[0023] In the figures: 1. Concentration mechanism; 101. Concentration chamber; 102. Connecting flange; 103. Flow regulating valve; 104. Solenoid valve; 105. Delivery pipe; 106. Annular pipe; 107. Base; 108. Support rod; 109. Electric heating ring; 110. Temperature sensor; 111. Nitrogen gas nozzle; 2. Sample storage mechanism; 201. Lifting platform; 202. Sample tank; 203. Limiting rod; 204. Electric telescopic rod; 205. Support platform; 206. Positioning pin; 3. Controller. Detailed implementation mode

[0024] Please refer to Figures 1-5 , a molecular diagnostic sample concentration device, including a concentration mechanism 1, and a sample storage mechanism 2 is arranged inside the concentration mechanism 1.

[0025] Furthermore, the concentration mechanism 1 includes a concentration chamber 101, several nitrogen nozzles 111 are installed on the surface of the concentration chamber 101, the air outlet end of the nitrogen nozzle 111 penetrates into the inner cavity of the concentration chamber 101, the air inlet end of the nitrogen nozzle 111 is connected to a flow regulating valve 103, the air inlet end of the flow regulating valve 103 is connected to an annular pipe 106, a delivery pipe 105 is connected to the surface of the annular pipe 106, and the air inlet end of the delivery pipe 105 is connected to an electromagnetic valve 104.

[0026] Furthermore, a connecting flange 102 is fixedly connected to the top of the concentration chamber 101, and the connecting flange 102 is connected to a ventilation system.

[0027] Furthermore, an electric heating ring 109 is fixedly connected to the bottom of the concentration chamber 101, and the electric heating ring 109 is movably sleeved on the surface of the sample tank 202.

[0028] Furthermore, a temperature sensor 110 is fixedly installed on the inner wall of the concentration chamber 101, and the detection end of the temperature sensor 110 extends into the inner cavity of the sample tank 202.

[0029] Furthermore, the sample storage mechanism 2 includes a lifting platform 201, a sample tank 202 is movably connected to the top of the lifting platform 201, the sample tank 202 is located inside the concentration chamber 101 and is slidably connected to its inner wall, and the top of the sample tank 202 is located at the bottom of the air outlet end of the nitrogen nozzle 111.

[0030] Furthermore, positioning pins 206 are fixedly connected to the four corners of the bottom of the sample tank 202, and the positioning pins 206 penetrate to the bottom of the lifting platform 201 and are movably connected to it.

[0031] Furthermore, limiting rods 203 are fixedly connected to both the left and right sides of the top of the lifting platform 201, and the tops of the limiting rods 203 are movably connected to the bottom of the concentration chamber 101.

[0032] Furthermore, electric telescopic rods 204 are fixedly connected to both the left and right sides of the bottom of the lifting platform 201, a support platform 205 is fixedly connected to the bottom of the electric telescopic rod 204, a support rod 108 is fixedly connected to the surface of the concentration chamber 101, a base 107 is fixedly connected to the bottom of the support rod 108, the bottom of the support platform 205 is fixedly connected to the top of the base 107, and a controller 3 is fixedly installed on the top of the base 107.

[0033] When concentrating the sample, the solenoid valve 104 is opened, and nitrogen gas enters from the delivery pipe 105. The nitrogen gas flows through the annular pipe 106 and then enters the flow regulating valve 103. The flow of nitrogen gas is controlled by the flow regulating valve 103. Finally, it is blown towards the sample in the sample tank 202 through the nitrogen gas nozzle 111, accelerating the evaporation of the solvent, thereby achieving the purpose of concentration. During the nitrogen blowing process, the electric heating ring 109 heats the liquid in the sample tank 202 to improve the evaporation efficiency. The temperature sensor 110 monitors the temperature inside the sample tank 202 and feeds it back to the controller 3 to ensure that the concentration process is carried out at an appropriate temperature. The connecting flange 102 is connected to the ventilation system for discharging the steam and waste gas generated during the concentration process.

[0034] After concentration is completed, the lifting platform 201 moves downward through the electric telescopic rod 204 to lower the sample tank 202. The positioning pin 206 ensures the stability of the sample tank 202 during the downward movement. After the downward movement is completed, the sample tank 202 disengages from the concentration chamber 101 and moves to its bottom. The user can take out the sample tank 202 and the sample inside it. When it is necessary to continue concentrating the sample, the electric telescopic rod 204 drives the sample tank 202 to reset. The limit rod 203 restricts the positions of the lifting platform 201 and the sample tank 202 to ensure that the sample tank 202 moves to the bottom of the nitrogen gas nozzle 111.

[0035] The nitrogen gas nozzles 111 are evenly distributed around the concentration chamber 101 to ensure that nitrogen gas can effectively blow towards the sample in the sample tank 202, accelerating the evaporation of the solvent. The flow regulating valve 103 can precisely control the nitrogen gas flow rate to meet the requirements of different sample volumes. The electric heating ring 109 surrounds the sample tank 202 and can evenly heat the sample tank 202 to improve the evaporation efficiency. The temperature sensor 110 monitors the temperature inside the sample tank 202 to ensure that the heating process is carried out within an appropriate temperature range and avoid overheating to damage the sample. The controller 3 can automatically adjust the heating power and nitrogen gas flow rate according to the data fed back by the temperature sensor 110 to ensure that the concentration process is efficient and safe. The lifting platform 201 moves up and down through the electric telescopic rod 204 to facilitate the taking and placing of the sample tank 202. The positioning pin 206 and the limit rod 203 ensure the accurate and stable position of the sample tank 202 during the concentration process. By significantly shortening the concentration time, the laboratory work efficiency is improved. The efficient concentration process reduces energy consumption and lowers the operating cost.

[0036] The above is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent replacements, and improvements made within the spirit and principle of the present utility model shall be included within the protection scope of the present utility model.

Claims

1. A molecular diagnostic sample concentration device, comprising a concentration mechanism (1), and a sample storage mechanism (2) is arranged inside the concentration mechanism (1), characterized in that: The concentration mechanism (1) includes a concentration chamber (101), several nitrogen nozzles (111) are installed on the surface of the concentration chamber (101), the air outlet end of the nitrogen nozzle (111) penetrates into the inner cavity of the concentration chamber (101), the air inlet end of the nitrogen nozzle (111) is communicated with a flow regulating valve (103), the air inlet end of the flow regulating valve (103) is communicated with an annular pipe (106), a delivery pipe (105) is communicated with the surface of the annular pipe (106), and the air inlet end of the delivery pipe (105) is communicated with a solenoid valve (104); The sample storage mechanism (2) includes a lifting table (201), a sample tank (202) is movably connected to the top of the lifting table (201), the sample tank (202) is located inside the concentration chamber (101) and is slidably connected to its inner wall, and the top of the sample tank (202) is located at the bottom of the air outlet end of the nitrogen nozzle (111).

2. The molecular diagnostic sample concentration device according to claim 1, wherein: A connecting flange (102) is fixedly connected to the top of the concentration chamber (101), and the connecting flange (102) is connected to a ventilation system.

3. A molecular diagnostic sample concentration device according to claim 1, characterized in that: An electric heating ring (109) is fixedly connected to the bottom of the concentration chamber (101), and the electric heating ring (109) is movably sleeved on the surface of the sample tank (202).

4. A molecular diagnostic sample concentration device according to claim 3, characterized in that: A temperature sensor (110) is fixedly installed on the inner wall of the concentration chamber (101), and the detection end of the temperature sensor (110) extends into the inner cavity of the sample tank (202).

5. The molecular diagnostic sample concentration device according to claim 1, characterized in that: Positioning pins (206) are fixedly connected to the four corners of the bottom of the sample tank (202), and the positioning pins (206) penetrate to the bottom of the lifting table (201) and are movably connected thereto.

6. The molecular diagnostic sample concentration device according to claim 1, characterized in that: Limit rods (203) are fixedly connected to both the left and right sides of the top of the lifting table (201), and the tops of the limit rods (203) are movably connected to the bottom of the concentration chamber (101).

7. A molecular diagnostic sample concentration device according to claim 1, characterized in that: Electric telescopic rods (204) are fixedly connected to both the left and right sides of the bottom of the lifting table (201), a support table (205) is fixedly connected to the bottom of the electric telescopic rod (204), a support rod (108) is fixedly connected to the surface of the concentration chamber (101), a base (107) is fixedly connected to the bottom of the support rod (108), the bottom of the support table (205) is fixedly connected to the top of the base (107), and a controller (3) is fixedly installed on the top of the base (107).

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