Electric adjusting luggage carrier applied to living cell imager

Abstract

The utility model discloses an electric adjusting carrier applied to a living cell imager, which comprises a frame main body, an objective table arranged on the frame main body and a perforated plate outer frame arranged on the objective table, and a group of driving motors and an XY axial linkage mechanism are arranged in the frame main body. The group of driving motors drive the XY axial linkage mechanism to work, and the perforated plate outer frame is connected with the XY axial linkage mechanism. According to the utility model, the XY axial linkage mechanism is concentrated in the frame main body, and the XY axial linkage mechanism is controlled by a group of motors, so that the precise alignment of the perforated plate outer frame in the XY axial direction can be realized, and the alignment precision and the convenience degree of alignment control can be improved; due to the highly concentrated design, the carrier is small in size, the overall size is not influenced when the carrier is carried on the living cell imager, the working distance of the imager in the Z-axis direction is not influenced, and the carrier is attractive and elegant; the XY axial linkage mechanism is mainly composed of a guide rail, a pull rope, a sliding block and other conventional parts, and the production cost and difficulty can be reduced.

Description

Technical Field

[0001] The utility model belongs to the technical field of live cell imaging instrument carriers, in particular to an electric adjustment carrier applied to a live cell imaging instrument. Background Art

[0002] In the field of life sciences, a live cell imager is a device placed in an incubator to perform long-term real-time dynamic monitoring of biological samples. Considering the characteristics of the live cell imager working in an incubator, the imager is small and compact and only has single-hole imaging capabilities.

[0003] Live-cell imagers are usually equipped with well plates for placing samples for observation. The open loading platforms of existing live-cell imagers do not have the function of accurately adjusting the position of the well plates in the X-axis and Y-axis directions, and the well plates cannot be fixed. When observing samples, the operator needs to manually move the well plates to align the samples. After taking out the well plates for liquid exchange during observation, it is difficult to put them back in place for observation. The operator needs to readjust the position of the well plates based on experience, which is time-consuming and labor-intensive. Currently, there are two types of loading platforms used on microscopes: manual and electric. Since electric stages have functions such as automatic positioning and high-precision sample movement, they can improve user experience and are therefore widely popular. However, the loading platforms on current microscopes are difficult to directly assemble onto live-cell imagers, and the integrated volume is relatively large, and the dual guide rails are difficult to adjust.

[0004] The information disclosed in this background technology section is only intended to increase the understanding of the overall background of the present invention, and should not be regarded as an admission or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. Utility Model Content

[0005] The purpose of the present invention is to provide an electrically adjustable carrier for use in a living cell imaging instrument, thereby overcoming the above-mentioned defects in the prior art.

[0006] In order to achieve the above-mentioned purpose, the utility model provides an electric adjustment carrier for use in a living cell imaging instrument, comprising a frame body, a carrier stage arranged on the frame body, and a multi-well plate outer frame arranged on the carrier stage. A group of drive motors and an XY axial linkage mechanism are provided in the frame body, the group of drive motors drives the XY axial linkage mechanism to work, and the multi-well plate outer frame is connected to the XY axial linkage mechanism.

[0007] Further, as a preference, the XY axial linkage mechanism includes a crossbeam, an X-axis guide rail arranged in the crossbeam, a first slider and a second slider arranged in the frame body and located at both ends of the crossbeam, a first Y-axis guide rail and a second Y-axis guide rail arranged in the frame body and perpendicular to the X-axis guide rail, and a linkage rope, the first slider is arranged on the first Y-axis guide rail, the second slider is arranged on the second Y-axis guide rail, an X-axial slider is provided on the X-axis guide rail, the X-axial slider is connected to the outer frame of the porous plate, a traction wheel group is provided in the first slider and the second slider, and the linkage rope connects a group of drive motors, the traction wheel group and the X-axial slider.

[0008] Further, preferably, the group of driving motors includes a first motor and a second motor, and the first motor and the second motor are symmetrically arranged in the frame body.

[0009] Further, as a preference, the traction wheel group consists of a traction wheel running parallel to the first Y-axis guide rail and the second Y-axis guide rail, and a traction wheel running parallel to the X-axis guide rail.

[0010] Furthermore, preferably, there are at least two traction wheels extending parallel to the first Y-axis guide rail and the second Y-axis guide rail, and there are also at least two traction wheels extending parallel to the X-axis guide rail.

[0011] Furthermore, preferably, a group of limiting grooves are provided on the loading platform, and the first slider and the second slider slide in the limiting groove area.

[0012] Furthermore, as a preference, an L-shaped connecting block is further provided on the X-axial sliding block, and the L-shaped connecting block is connected to the outer frame of the porous plate.

[0013] Furthermore, preferably, the frame body is a U-shaped structure, and the loading platform is a thin plate structure.

[0014] Furthermore, preferably, a porous plate fixing piece is provided on the porous plate outer frame, and a spring steel wire for fixing the porous plate is provided on the porous plate fixing piece.

[0015] Furthermore, preferably, a motor control knob is provided on the outside of the frame body.

[0016] Compared with the prior art, the present invention has the following beneficial effects:

[0017] The utility model concentrates the XY axial linkage mechanism in the frame body, which can realize the precise alignment of the outer frame of the multi-hole plate in the XY axial direction, thereby improving the observation efficiency. The utility model has a small and compact size and does not affect the working distance in the Z axial direction.

[0018] The utility model controls the XY axial linkage mechanism through a set of motors, which can improve the control accuracy, has a simple structure and high integration;

[0019] The XY axial linkage mechanism of the utility model is mainly composed of conventional parts such as guide rails, pull ropes and sliders. The parts assembly is simple and does not require too many complicated parts assembly, which can reduce the cost and difficulty of production.

[0020] The electric adjustment carrier of the utility model can be used independently from the living cell imaging instrument;

[0021] The utility model can centrally control remote control software on the driving motor, and the purpose of remotely observing samples in the incubator can be achieved by mounting the utility model on a living cell imager. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a schematic diagram of the electric adjustment carrier of the present invention being mounted on a live cell imaging instrument;

[0023] Figure 2 This is a schematic diagram of an electrically adjustable specimen carrier for use in a living cell imaging instrument according to the present invention;

[0024] Figure 3 This is a schematic diagram of the interior of an electrically adjustable specimen carrier used in a living cell imaging instrument according to the present invention;

[0025] Figure 4 This is an internal top view of an electrically adjustable specimen carrier used in a living cell imaging instrument according to the present invention;

[0026] Figure 5 It is an enlarged schematic diagram of the first slider of the present invention;

[0027] Figure 6 It is an enlarged schematic diagram of the traction wheel assembly of the present utility model;

[0028] Figure markings: 100-living cell imager, 1-frame body, 101-motor control knob, 2-stage, 201-limiting groove, 3-porous plate outer frame, 301-porous plate fixing member, 302-spring steel wire, 4-driving motor, 401-first motor, 402-second motor, 5-XY axial linkage mechanism, 501-crossbeam, 502-X-axial guide rail, 503-first slider, 504-second slider, 505-first Y-axial guide rail, 506-second Y-axial guide rail, 507-linkage rope, 508-X-axial slider, 509-traction wheel group, 6-L-shaped connecting block. DETAILED DESCRIPTION

[0029] The specific implementation methods of the present invention are described in detail below, but it should be understood that the protection scope of the present invention is not limited by the specific implementation methods.

[0030] The following is a brief summary of one or more aspects to provide a basic understanding of these aspects. This summary is not an exhaustive overview of all conceivable aspects and is neither intended to identify key or critical elements of all aspects nor to define the scope of any or all aspects. Its sole purpose is to present some concepts of one or more aspects in a simplified form as a prelude to the more detailed description that will be provided later.

[0031] like Figure 1-6 As shown, an electric adjustment carrier used in a living cell imaging instrument includes a frame body 1, a stage 2 arranged on the frame body 1, and a multi-well plate outer frame 3 arranged on the stage 2. A group of drive motors 4 and an XY axial linkage mechanism 5 are provided in the frame body 3. The group of drive motors 4 drives the XY axial linkage mechanism 5 to work, and the multi-well plate outer frame 3 is connected to the XY axial linkage mechanism 5.

[0032] During operation, the stage 2 is installed on the live cell imager 100, the sample to be observed is placed on the porous plate, and then the porous plate is placed on the porous plate outer frame 3. The XY axial linkage mechanism 5 is driven by the drive motor 4 to move in the XY axial direction, thereby achieving precise alignment of the sample on the porous plate for observation of the sample.

[0033] In this embodiment, as a specific solution, the XY axial linkage mechanism 5 includes a beam 501, an X-axis guide rail 502 arranged in the beam 501, a first slider 503 and a second slider 504 arranged in the frame body 1 and located at both ends of the beam 501, a first Y-axis guide rail 505 and a second Y-axis guide rail 506 arranged in the frame body 1 and perpendicular to the X-axis guide rail 502, and a linkage rope 507, the first slider 503 is arranged on the first Y-axis guide rail 505, the second slider 504 is arranged on the second Y-axis guide rail 506, an X-axis slider 508 is provided on the X-axis guide rail 502, the X-axis slider 508 is connected to the porous plate outer frame 3, a traction wheel group 509 is provided in the first slider 503 and the second slider 504, and the linkage rope 507 connects a group of drive motors 4, the traction wheel group 509 and the X-axis slider 508.

[0034] Principle description: During XY axial movement adjustment, the driving motor 4 drives the linkage rope 507 to move, and the linkage rope 507 drives the first slider 503 to move in the Y-axis on the first Y-axis guide rail 505, the second slider 504 to move in the Y-axis on the second Y-axis guide rail 506, and the X-axis slider 508 to move in the X-axis on the X-axis guide rail 502, thereby enabling the porous plate outer frame 3 to realize XY axial linkage to achieve precise alignment and improve observation efficiency.

[0035] In this embodiment, as a specific solution, the group of drive motors 4 includes a first motor 401 and a second motor 402, and the first motor 401 and the second motor 402 are symmetrically arranged in the frame body 1; the two motors are highly concentrated inside the frame body 1, and the two motors simultaneously control two Y-axial movements and one X-axial movement, which can achieve high-precision control. Specifically, the speed of the motor can be determined by calculation, so that the two motors can be precisely coordinated (the calculation part does not fall within the scope of structural protection of this application, so it will not be explained in detail).

[0036] In this embodiment, as a specific solution, the traction wheel group 509 is composed of a traction wheel that runs parallel to the first Y-axis guide rail 505 and the second Y-axis guide rail 506, and a traction wheel that runs parallel to the X-axis guide rail 502; by adopting a two-directional traction wheel combination design, the linkage pull rope 507 can be displaced in the X-axis direction and the Y-axis direction; the traction wheels are concentrated inside the first slider 503 and the second slider 504, and the structure is simple; a more specific traction wheel can be a V-shaped wheel.

[0037] In this embodiment, as a specific solution, there are at least two traction wheels running parallel to the first Y-axis guide rail 505 and the second Y-axis guide rail 506, and there are also at least two traction wheels running parallel to the X-axis guide rail 502; the use of more than two traction wheels in both the Y-axis direction and the X-axis direction can improve the stability of the linkage pull rope 507, thereby improving the stability of the movement of the first slider 503, the second slider 504 and the X-axis slider 508.

[0038] In this embodiment, as a specific solution, a group of limit grooves 201 are provided on the stage 2, and the first slider 503 and the second slider 504 slide within the area of the limit grooves 201; the setting of the limit grooves 201 plays a certain limiting role in the sliding distance of the first slider 503 and the second slider 504, which can ensure that the porous plate outer frame 3 is always within the area of the stage 2, and avoids moving to the outside of the stage 2 to affect observation.

[0039] In this embodiment, as a specific solution, an L-shaped connecting block 6 is also provided on the X-axial slider 508, and the L-shaped connecting block 6 is connected to the porous plate outer frame 3; by providing the L-shaped connecting block 6, it can be ensured that the porous plate outer frame 3 is located above the worktable 2 in a flat state.

[0040] In this embodiment, as a specific solution, the frame body 1 is a U-shaped structure, and the stage 2 is a thin plate-like structure. When the stage 2 is installed on the living cell imager 100, the U-shaped frame body 1 surrounds the three sides of the living cell imager 100 without affecting the Z-axis working distance of the imager, forming a highly symmetrical and compact structure as a whole.

[0041] In this embodiment, as a specific solution, a porous plate fixing part 301 is further provided on the porous plate outer frame 3, and a spring steel wire 302 for fixing the porous plate is provided on the porous plate fixing part 301; the porous plate placed on the porous plate outer frame 3 can be fixed by the spring steel wire 302 to ensure that the sample on the porous plate is in a fixed state for easy observation; the spring steel wire 302 can be set in the X-axis direction and the Y-axis direction respectively, so that it can be fixed from both directions.

[0042] In this embodiment, as a specific solution, a motor control knob 101 is provided on the outside of the frame body 1 .

[0043] In this embodiment, as a specific solution, control software can be built into the first motor 401 and the second motor 402, and the operation of the motors can be remotely controlled by the control software. At the same time, the living cell imager 100 also has remote control software. When the present application is mounted on the living cell imager 100 and the sample needs to be placed in an incubator for culture, it can be placed in the incubator together with the living cell imager 100 for culture, and then the motors can be remotely controlled by a computer to achieve remote alignment and remote observation of the sample.

[0044] The utility model concentrates the XY axial linkage mechanism in the frame body, and controls the XY axial linkage mechanism through a group of motors to achieve precise alignment of the multi-well plate outer frame in the XY axial direction, which can improve the alignment accuracy and the convenience of alignment control; and the highly centralized setting makes the carrier compact, and it will not affect the overall size when mounted on the living cell imager, nor will it affect the working distance of the imager in the Z axis, which is simple and elegant.

[0045] In addition, the XY axial linkage mechanism of the present invention is mainly composed of conventional parts such as guide rails, pull ropes and sliders, and is controlled by a group of motors. It has high control accuracy, convenient operation, simple parts assembly, and does not require too many complex fine-processing parts combinations, which can reduce the cost and difficulty of production. The electric adjustment carrier can be used independently without the live cell imager. The remote control software can also be centralized on the drive motor, and the present invention can be installed on the live cell imager to achieve the purpose of remote observation of samples in the incubator.

[0046] The foregoing descriptions of specific exemplary embodiments of the present invention are for purposes of illustration and description. These descriptions are not intended to limit the present invention to the precise forms disclosed, and it is apparent that many modifications and variations are possible in light of the foregoing teachings. The exemplary embodiments have been selected and described for the purpose of explaining the specific principles of the present invention and their practical application, thereby enabling those skilled in the art to realize and utilize a variety of exemplary embodiments of the present invention and various options and variations. The scope of the present invention is intended to be defined by the claims and their equivalents.

Claims

1. A motorized adjustable specimen carrier for use in a live cell imaging instrument, characterized in that: It includes a frame body, a loading platform arranged on the frame body, and a porous plate outer frame arranged on the loading platform. A group of drive motors and an XY axial linkage mechanism are provided in the frame body. The group of drive motors drives the XY axial linkage mechanism to work, and the porous plate outer frame is connected to the XY axial linkage mechanism.

2. The electrically adjustable specimen carrier for a living cell imaging instrument according to claim 1, characterized in that: The XY axial linkage mechanism includes a crossbeam, an X-axis guide rail arranged in the crossbeam, a first slider and a second slider arranged in the frame body and located at both ends of the crossbeam, a first Y-axis guide rail and a second Y-axis guide rail arranged in the frame body and perpendicular to the X-axis guide rail, and a linkage rope, the first slider is arranged on the first Y-axis guide rail, the second slider is arranged on the second Y-axis guide rail, an X-axial slider is provided on the X-axis guide rail, the X-axial slider is connected to the outer frame of the porous plate, a traction wheel group is provided in the first slider and the second slider, and the linkage rope connects a group of drive motors, the traction wheel group and the X-axial slider.

3. The electrically adjustable specimen carrier for a living cell imaging instrument according to claim 1, characterized in that: The set of driving motors includes a first motor and a second motor, and the first motor and the second motor are symmetrically arranged in the frame body.

4. The electrically adjustable specimen carrier for a living cell imaging instrument according to claim 2, characterized in that: The traction wheel group consists of a traction wheel that runs parallel to the first Y-axis guide rail and the second Y-axis guide rail, and a traction wheel that runs parallel to the X-axis guide rail.

5. The electrically adjustable specimen carrier for a living cell imaging instrument according to claim 4, characterized in that: There are at least two traction wheels extending parallel to the first Y-axis guide rail and the second Y-axis guide rail, and there are also at least two traction wheels extending parallel to the X-axis guide rail.

6. The electrically adjustable specimen carrier for a living cell imaging instrument according to claim 2, characterized in that: The loading platform is provided with a group of limiting grooves, and the first slider and the second slider slide in the limiting groove area.

7. The electrically adjustable specimen carrier for a living cell imaging instrument according to claim 2, characterized in that: The X-axial sliding block is further provided with an L-shaped connecting block, and the L-shaped connecting block is connected to the outer frame of the porous plate.

8. The electrically adjustable specimen carrier for a living cell imaging instrument according to claim 1, characterized in that: The frame body is a U-shaped structure, and the loading platform is a thin plate structure.

9. The electrically adjustable specimen carrier for a living cell imaging instrument according to claim 1, characterized in that: A porous plate fixing piece is also provided on the porous plate outer frame, and a spring steel wire for fixing the porous plate is provided on the porous plate fixing piece.

10. The electrically adjustable specimen carrier for a living cell imaging instrument according to claim 1, characterized in that: A motor control knob is provided outside the frame body.

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