Tumor electric field treatment device and electrode plate thereof

Abstract

The utility model provides a tumor electric field treatment device and an electrode plate thereof. The electrode plate comprises a backing, an electrode array attached to the front face of the backing and a plurality of pasting pieces attached to the front face of the electrode array, and the electrode array comprises a flexible circuit board and a plurality of electrode units arranged on the flexible circuit board. The electrode slice further comprises a heat dissipation patch, the heat dissipation patch and the electrode array are arranged in an up-down overlapping mode through the backing, and the heat dissipation patch comprises a hydrogel layer attached to the back face of the backing. The heat dissipation patch is arranged on the back surface of the electrode plate, so that the heat dissipation performance of the electrode plate can be improved, and the treatment time of the electrode plate is prolonged.

Description

Technical Field

[0001] The present application relates to a tumor electric field treatment device and an electrode sheet thereof for tumor electric field treatment. Background Art

[0002] Medium-frequency alternating electric field therapy has been shown to be an effective method for tumor treatment, capable of disrupting the mitotic process of cancer cells and inducing apoptosis, making it suitable for treating tumors. A tumor electric field therapy device typically includes an electric field generator, an adapter, and multiple pairs of electrodes. The electric field generator generates an alternating electrical signal, which is transmitted to the electrodes via the adapter. The electrodes are applied in pairs to opposite sides of the patient's skin, applying an alternating current signal between each pair of electrodes, thereby non-invasively applying the tumor-treating electric field to the target area.

[0003] Chinese Utility Model Patent Publication No. 218944166U discloses a cell division inhibition device comprising electrodes, a coolant base, and a filling structure. The electrodes are used to output an alternating electric field to target biological tissue; the coolant base is connected to one side of the electrodes and is at least partially used to dissipate heat by exchanging heat with the electrodes; and the filling structure is connected to the side of the coolant base closest to the electrodes and is used to at least partially fill the gap between the electrodes. While this cell division inhibition device can dissipate heat for the electrodes, its liquid cooling method is complex, inconvenient to carry, and relatively expensive.

[0004] Therefore, there is a need to improve the existing tumor electric field treatment device and its electrode sheet. Utility Model Content

[0005] The present application provides a tumor electric field treatment device and an electrode sheet thereof, wherein the electrode sheet has good heat dissipation performance.

[0006] Specifically, the present application is implemented through the following technical solution: an electrode sheet, including a backing, an electrode array attached to the front of the backing, and several adhesive parts attached to the front of the electrode array, the electrode array including a flexible circuit board and several electrode units arranged on the flexible circuit board, and also including a heat sink, the heat sink and the electrode array are arranged to overlap with each other above and below with the backing separated, and the heat sink includes a hydrogel layer applied to the back of the backing.

[0007] Furthermore, the heat dissipation patch also includes a heat dissipation backing layer covering the back side of the hydrogel layer, and the heat dissipation backing layer is made of non-woven fabric.

[0008] Furthermore, the main components of the hydrogel layer are monomers of natural water-soluble polymers or synthetic water-soluble polymers, glycerol, additives and purified water.

[0009] Furthermore, the heat dissipation patch is also provided with a plurality of penetrating heat dissipation holes.

[0010] Furthermore, the heat dissipation patch also includes a graphite layer arranged on the back side of the heat dissipation backing layer.

[0011] Furthermore, the outline size of the heat dissipation sticker is larger than the size of the electrode array and smaller than the outline size of the backing.

[0012] Furthermore, the backing is provided with a window, the outline size of the window is larger than the outline size of the electrode array and smaller than the outline size of the heat dissipation patch, and the heat dissipation patch is directly adhered to the back of the electrode array through the window.

[0013] Furthermore, the electrode array is provided with a plurality of open spaces, and the heat dissipation patch has notches corresponding to the open spaces.

[0014] Furthermore, the electrode unit includes a metal layer provided on the front surface of the flexible circuit board and electrically connected thereto, a dielectric layer provided corresponding to and laid on the metal layer, and a portion of the flexible circuit board corresponding to the metal layer.

[0015] The present application also provides the following technical solution: a tumor electric field treatment device, which includes an electric field generator, an adapter and several of the aforementioned electrode sheets, wherein the adapter electrically connects the electric field generator and each of the electrode sheets.

[0016] The tumor electric field treatment device of the present application can improve the heat dissipation performance of the electrode sheet and extend the treatment time of the electrode sheet by providing a heat dissipation patch on the back of the electrode sheet.

[0017] It should be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 1 is a schematic diagram of a tumor treatment field device according to one embodiment of the present application;

[0019] Figure 2 is a front plan view of an electrode sheet according to one embodiment of the present application;

[0020] Figure 3 for Figure 2 A back plan view of the electrode sheet shown in FIG.

[0021] Figure 4 for Figure 2 A perspective exploded view of the electrode sheet shown in FIG;

[0022] Figure 5 For the Figure 2 The cross-sectional view obtained in the AA direction;

[0023] Figure 6 for Figure 5 Enlarged view of the middle circle;

[0024] Figure 7 and Figure 3 Similarly, another embodiment of an electrode sheet including a backing is shown;

[0025] Figure 8 and Figure 7 Similarly, it shows the Figure 3 A modified embodiment of the heat dissipation sticker of the electrode sheet shown in Figure 3 A schematic diagram of the structure of the backing shown in ;

[0026] Figure 9 is a front plan view of an electrode sheet according to another embodiment of the present application;

[0027] Figure 10 for Figure 9 A back plan view of the electrode sheet shown in FIG.

[0028] Figure 11 for Figure 9 A plan view of the electrode array of the electrode sheet shown in FIG.

[0029] Figure 12 and Figure 10 Similarly, the display is for Figure 9 A schematic structural diagram of a modified embodiment of the heat dissipation sticker of the electrode sheet and the backing shown in FIG. DETAILED DESCRIPTION

[0030] Exemplary embodiments are described in detail herein, with examples illustrated in the accompanying drawings. When the following description refers to the drawings, identical numerals in different figures represent identical or similar elements unless otherwise indicated. The embodiments described in the following exemplary embodiments are not intended to represent all embodiments consistent with the present application. Rather, they are merely examples of devices, systems, apparatus, and methods consistent with certain aspects of the present application.

[0031] refer to Figure 1 As shown, the tumor treatment field device 100 includes an electric field generator 10, an adapter 20, and a plurality of paired electrode pads 30. The adapter 20 electrically connects the electric field generator 10 to each electrode pad 30. The electric field generator 10 generates the alternating current (AC) signal required for treatment. The adapter 20 receives the AC signal from the electric field generator 10 and transmits it to the electrode pads 30. The paired electrode pads 30 are attached to the patient's body surface corresponding to the tumor area, applying the AC signal to the patient's tumor area for tumor treatment field therapy.

[0032] refer to Figures 2 to 4 As shown, the electrode sheet 30 includes a backing 31, an electrode array 32 attached to the front of the backing 31, several adhesive members 33 attached to the front of the electrode array 32, and a heat dissipation patch 34 attached to the back of the backing 31. The electrode sheet 30 is applied with its front side facing the patient. The sides of the backing 31, electrode array 32, adhesive members 33, and heat dissipation patch 34 facing the patient's skin are their respective front sides. The backing 31 is sheet-shaped, and its front side facing the patient's body surface is coated with a biocompatible adhesive (not shown), which allows the electrode array 32 to be tightly attached to the patient's body surface corresponding to the tumor site.

[0033] The electrode array 32 includes a flexible circuit board 321, a plurality of electrode units 322, and a plurality of temperature sensors (not shown). The electrode array 32 is arranged in a roughly "W" shape. The plurality of electrode units 322 are arranged in a three-row, three-column array on the front of the flexible circuit board 321. The plurality of temperature sensors (not shown) are arranged in eight rows and eight columns, respectively, on eight of the electrode units 322. The electrode array 32 also forms a plurality of open spaces D to facilitate heat dissipation and allow for appropriate adjustment of the application position of the electrode units 322. The flexible circuit board 321 has a connecting portion 3211 connecting two adjacent electrode units 322 and a connecting portion 3212 welded to a wire (not shown). The wire (not shown) is used to electrically connect the electrode sheet 30 to the adapter 20. The electrode array 32 is electrically connected to the electric field generator 10 via the adapter 20 to enable transmission of AC signals and temperature detection signals between the electrode array 32 and the electric field generator 10.

[0034] Combine Figure 5 and Figure 6As shown, each electrode unit 322 includes a metal layer 3221 provided on the front side of the flexible circuit board 321 and electrically connected thereto, a dielectric layer 3222 provided corresponding to and laid on the metal layer 3221, and a portion of the flexible circuit board 321 corresponding to the corresponding metal layer 3221. The metal layer 3221 can be a metal material such as copper. The dielectric layer 3222 can be a dielectric ceramic or a polymer dielectric layer with a high dielectric constant and low dielectric loss. The polymer dielectric layer is made of a thin film material with a non-fixed crystal orientation, high flexibility and high toughness. In this embodiment, the material of the dielectric layer 3222 is a polymer with a dielectric constant of not less than 20 and a dielectric strength of not less than 40V / μm to prevent the dielectric layer 3222 from being broken down under normal applied voltage. The polymer exhibits relaxor ferroelectric behavior and can be a vinylidene fluoride-based polymer, such as P(VDF-TrFE-CTFE), P(VDF-TrFE-CFE), or P(VDF-TrFE-CFE-CTFE), or a polyamide composite material, such as piperazine-biuret copolymer. The dielectric layer 3222 can be formed on the surface of the metal layer 3221 by vapor deposition, sputtering, or ion plating, or by printing, spraying, or casting. The thickness of the dielectric layer 3222 is 3 μm to 10 μm.

[0035] refer to Figure 3 Combined with Figure 5 and Figure 6 As shown, one side of adhesive member 33 is attached to electrode unit 322, while the other side of adhesive member 33 serves as a patch layer applied to the skin surface of the human body, keeping the skin surface moisturized and relieving localized pressure. Adhesive member 33 can be a conductive adhesive member that acts as a conductive medium, preferably a conductive hydrogel.

[0036] The heat dissipation patch 34 is roughly rectangular and is arranged to overlap the electrode array 32 above and below the backing 31. The electrode array 32 is arranged on the front of the backing 31, and the heat dissipation patch 34 is arranged on the back of the backing 31 corresponding to the electrode array 32. The area of ​​the heat dissipation patch 34 is smaller than the area of ​​the backing 31, but larger than the overall outline of the electrode array 32 (excluding the area of ​​the wiring portion 3212). The heat dissipation patch 34 includes a hydrogel layer 341 applied to the back of the backing 31 and a heat dissipation backing layer 342 covering the back of the hydrogel layer 341. The heat dissipation backing layer 342 is made of a non-woven fabric with micropores. The main components of the hydrogel layer 341 are monomers of natural water-soluble polymers or synthetic water-soluble polymers, glycerin, additives, and purified water. The hydrogel layer 341 absorbs heat from each electrode unit 322 on the electrode array 32 according to the laws of thermodynamics and conducts the heat to the external environment, thereby reducing the temperature of the electrode unit 322. The heat absorbed by the hydrogel layer 341 is dissipated outward more quickly through the micropores on the heat dissipation backing layer 342 to achieve a cooling effect. At the same time, due to the difference in heat dissipation, the temperature of the hydrogel layer 341 will also drop again, which can further delay the time for the electrode unit 322 to reach the safe temperature threshold (for example, 41°C), increase the treatment time of the electrode sheet 30, and thus improve the effect of tumor electric field therapy. The heat dissipation patch 34 is also provided with a number of through-holes 344 to facilitate the evaporation of water in the hydrogel layer 341 and enhance the heat dissipation effect. It can be understood that the heat dissipation holes 344 are not necessary and can also be omitted.

[0037] The heat sink 34 also includes a graphite layer 343 disposed on the back of the heat sink backing layer 342. The graphite layer 343 can be bonded to the heat sink backing layer 342 by any method, such as coating, hot pressing, composite technology, or lamination technology, to form a composite material with excellent thermal conductivity. The graphite layer 343 can be composed of a synthetic graphite sheet, such as pyrolytic graphite, compressed high-purity exfoliated mineral graphite, or a graphitized polymer film. The thermal conductivity of the graphite layer 343 is much greater than that of the hydrogel layer 341, and can better conduct the heat generated by the electrode sheet 30 during operation from the electrode unit 322 through the hydrogel layer 341, the heat sink backing layer 342, and then through the graphite layer 343 to the external environment, thereby better reducing the operating temperature of the electrode unit 322.

[0038] refer to Figure 7 As shown, this application provides Figure 4 Another variant embodiment of the backing 31 shown in FIG is different from the backing 31 in that the backing 31' in this embodiment is provided with a window 311', and the window 311' is roughly rectangular, and its outline (see FIG. Figure 7The dotted line in the figure is slightly larger than the overall outline of the electrode array 32 (excluding the connection portion 3212), but smaller than the outline of the heat dissipation patch 34. The heat dissipation patch 34 can completely cover the window 311' and can be attached to the back of the electrode array 32 and the human body through the window 311', so that the heat dissipation patch 34 directly contacts the electrode array 32 and the human skin, achieving a better heat dissipation effect.

[0039] refer to Figure 8 As shown, this application provides Figure 3 Another variation of the heat dissipation sticker 34 shown is Figure 3 The difference between the heat dissipation patch 34 shown is that the heat dissipation patch 34' in this embodiment is provided with a notch 345' for the open space D. Since the temperature of the open space D is relatively low, no auxiliary heat dissipation is required. The notch 345' provided on the heat dissipation patch 34' can reduce manufacturing costs and improve heat dissipation efficiency.

[0040] Alternative implementation of electrode sheet

[0041] Figures 9 to 11 The figure shows an alternative embodiment for tumor electric field therapy. The electrode sheet 40 includes a backing 41, an electrode array 42 attached to the front of the backing 41, several adhesives 43 attached to the front of the electrode array 42, and a heat sink 44 attached to the back of the backing 41. The electrode array 42 includes a flexible circuit board 421, several electrode units 422 arranged in multiple rows and columns, and several temperature sensors (not shown). The structure of the electrode sheet 40 in this embodiment is similar to the electrode sheet 30 in the previous embodiment. The main difference is that the number and arrangement of the electrode units 422 of the electrode sheet 40 are different from the number and arrangement of the electrode units 322 of the electrode sheet 30. Accordingly, the shapes of the backing 41, electrode array 42, adhesives 43, and heat sink 44 are also slightly different. Only the main differences are described below.

[0042] The electrode array 42 is provided with twenty electrode units 422, and these twenty electrode units 422 are roughly arranged in an array of four rows and six columns. The first row and the fourth row are each provided with four electrode units 422, and the second row and the third row are each provided with six electrode units 422. The six electrode units 422 in each row of the second and third rows correspond one to another and are roughly arranged in six columns. The four electrode units 422 in each row of the first row and the fourth row are respectively located on the middle four columns.

[0043] The flexible circuit board 421 of the electrode array 42 includes a plurality of connection portions 4211 that connect adjacent electrode units 422 and a wiring portion 4212 for connecting external wires 45. The plurality of connection portions 4211 include a first connection portion 4211A that connects adjacent electrode units 422 in a row and a second connection portion 4211B that connects adjacent electrode units 422 in a column. Except for the middle two adjacent electrode units 422 in the second row and the middle two adjacent electrode units 422 in the third row, all other adjacent electrode units 422 in each row are connected via corresponding first connection portions 4211A. Adjacent electrode units 422 in the third and fourth columns are connected via second connection portions 4211B. The wiring portion 4212 is located between two adjacent second connection portions 4211B between the second and third rows, forming a roughly T-shape. There is no connecting portion 4211 between any two adjacent electrode units 422 in the first, second, fifth and sixth columns, but the electrode units 422 are arranged in a disconnected and spaced manner. A number of open spaces D1, D2, D4, D5, D6 are formed on the periphery between the twenty electrode units 422, which facilitates heat dissipation and allows for appropriate adjustment of the application position of the electrode units 322 at the end of each row.

[0044] Backing 41 is a single, roughly octagonal piece. Adhesive strips 43 are applied to each row of electrode elements 422, completely covering all of the electrode elements 422 in that row. Heat sink 44 is also a single, solid piece. Its outline is consistent with that of backing 41, but slightly smaller. The outline of heat sink 44 is larger than that of electrode array 42.

[0045] The hierarchical structure of the flexible circuit board 421 and electrode units 422 is identical to that of the flexible circuit board 321 and electrode units 322 in the previous embodiment. Each electrode unit 422 includes a metal layer (not shown) disposed on the front surface of the flexible circuit board 421 and electrically connected thereto, a dielectric layer (not shown) disposed corresponding to and laid on the metal layer (not shown), and a portion of the flexible circuit board 421 corresponding to the corresponding metal layer (not shown). For related details, please refer to the previous embodiment and will not be repeated here.

[0046] The hierarchical structure of the heat dissipation patch 44 is also the same as that of the heat dissipation patch 34 in the previous embodiment, including a hydrogel layer (not shown) applied to the back of the backing 41, a heat dissipation backing layer (not shown) covering the back of the hydrogel layer (not shown), and a graphite layer (not shown) provided on the back of the heat dissipation backing layer (not shown). Relevant content can be referred to the previous embodiment and will not be repeated here.

[0047] refer to Figure 12 As shown, this application provides Figure 10Another alternative embodiment of the heat dissipation patch 44 shown in FIG. 4 is different from the heat dissipation patch 44 in that the shape of the heat dissipation patch 44' in this embodiment is similar to the outline of the electrode array 42. For each open space D1, D2, D4, D5, D6 (see FIG. Figure 11 ) is provided with a notch 445 ', because the temperature of the open space D1-D6 is relatively low and no auxiliary heat dissipation is required, the heat dissipation patch 44' is provided with a notch 445' to reduce manufacturing costs and improve heat dissipation efficiency.

[0048] The above is only a preferred embodiment of the present application and is not intended to limit the present application. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present application should be included in the scope of protection of the present application.

Claims

1. An electrode sheet comprising a backing, an electrode array attached to the front surface of the backing, and a plurality of adhesive members attached to the front surface of the electrode array, wherein the electrode array comprises a flexible circuit board and a plurality of electrode units disposed on the flexible circuit board, characterized in that: It also includes a heat dissipation patch, which is arranged to overlap with the electrode array via the backing, and includes a hydrogel layer attached to the back of the backing.

2. The electrode sheet according to claim 1, characterized in that: The heat dissipation patch further includes a heat dissipation backing layer covering the back side of the hydrogel layer, and the heat dissipation backing layer is made of non-woven fabric.

3. The electrode sheet according to claim 1, wherein: The main components of the hydrogel layer are natural water-soluble polymer or synthetic water-soluble polymer monomer, glycerol, additives and purified water.

4. The electrode sheet according to claim 1, wherein: The heat dissipation patch is also provided with a plurality of penetrating heat dissipation holes.

5. The electrode sheet according to claim 2, characterized in that: The heat dissipation patch further includes a graphite layer arranged on the back side of the heat dissipation backing layer.

6. The electrode sheet according to claim 1, characterized in that: The outline size of the heat dissipation patch is larger than the outline size of the electrode array and smaller than the outline size of the backing.

7. The electrode sheet according to claim 6, characterized in that: The backing is provided with a window, the outline size of the window is larger than the outline size of the electrode array and smaller than the outline size of the heat dissipation patch, and the heat dissipation patch is directly adhered to the back of the electrode array through the window.

8. The electrode sheet according to claim 1, wherein: The electrode array is provided with a plurality of open spaces, and the heat dissipation patch has notches corresponding to the open spaces.

9. The electrode sheet according to claim 1, characterized in that: The electrode unit includes a metal layer arranged on the front of the flexible circuit board and electrically connected thereto, a dielectric layer arranged corresponding to and laid on the metal layer, and a portion of the flexible circuit board corresponding to the metal layer.

10. A tumor electric field treatment device, characterized in that: The device comprises an electric field generator, an adapter and a plurality of electrode sheets as claimed in any one of claims 1 to 9, wherein the adapter electrically connects the electric field generator and the electrode sheets.

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