Kit receiving basket and integrated reagent loading device

Abstract

The utility model discloses a kit receiving basket which comprises a groove type receiving part main body, the receiving part main body comprises a bottom plate, a detachable handle is embedded in the middle of the bottom plate, two receiving cavities are formed in the bottom plate by taking the handle as a partition, and the two receiving cavities are used for receiving kits. The detachable handle is connected with the receiving part main body in a relative lock catch type connection mode, the detachable handle structure enables the assembly of the kit to be simpler and more reliable, the processing cost is reduced, the utility model further discloses an integrated reagent loading device, a plurality of kit lifting baskets are integrated into a whole, and the integrated reagent loading device is convenient to use. A plurality of groups of equipment can be added into an automatic treatment instrument for working, and the applicability is high.

Description

Technical Field

[0001] The utility model relates to the field of medical devices, in particular to a reagent box receiving basket.

[0002] The utility model also relates to an integrated reagent loading device. Background Art

[0003] In vitro diagnostic technology is a medical testing method that tests samples from organisms outside the body of the test subject to obtain clinical diagnostic information and diagnose diseases or body functions. Through the reaction between in vitro diagnostic reagents and biological samples, a qualitative or quantitative diagnosis can be given, and then compared with normal values ​​to determine the patient's physiological state. It is known as the "doctor's eyes" in the medical field and is an important component of modern laboratory medicine. In clinical applications, it runs through the entire process of disease treatment, including disease prevention, preliminary diagnosis, treatment plan selection, and efficacy evaluation. Currently, in vitro diagnostic technology can detect a wide range of items, and there are also many systems that can operate fully automatically. One of the prerequisites for the efficient operation of automated detection systems is the integration of efficient reagent loading. Ultimately, the collaborative operation of various functional units can complete tests such as enzyme immunoassay or molecular diagnosis.

[0004] In existing in vitro diagnostic equipment, the enzyme-linked immunosorbent assay (ELISA) workstation can fully automatically complete the ELISA test, including dilution, sample distribution, reagent distribution, incubation, plate washing, enzyme label reading, result printing and other steps. This requires the participation of a large number of various reagents, and the dosage and stability characteristics of different reagents vary greatly. Therefore, there will be reagent kits of different specifications. In order to achieve more efficient reagent kit loading, reagent kit loading with high versatility and simple structure is necessary. However, in fact, there are few solutions for efficient and fool-proof reagent kit addition. Basket or drawer structures are widely used in the efficient transportation of sample tube racks and reagent kits. The existing patent US5632388A discloses a solution for configuring array-type sample tube receiving holes in a basket, which can achieve the goal of reliably transferring multiple sample tubes without shaking. CN2196155 In the solution disclosed by 91U, multiple columns of sample tube rack receiving units are arranged side by side and detachably connected to the sample tube rack basket, so that batch loading of sample tubes can be realized, and the risk of shaking of the sample tube rack is small. Overall, the basket is a transport relay; AU2019398123B2 discloses an integrated reagent sample and consumables adding part, which is equipped with a foldable handle. The solution limits the detailed connection scheme of the handle and the main body, and limits the folding storage direction to one end of the sample tube receiving position, and the handle does not affect the opening and closing operation of the sample tube cover after storage; in enzyme-linked immunosorbent assay, manual addition of various types of test kits one by one is inefficient and has certain risks of contamination and placement errors. Therefore, loading the test kit in a modular basket and then adding it as a whole into the enzyme-linked immunosorbent assay workstation is a prerequisite for automation and efficiency.

[0005] In summary, designing a reagent kit basket that can be added individually or in modular groups to automated processing instruments, especially those compatible with enzyme-linked immunosorbent assay devices or workstations, requires a simple structure, high versatility of components, and strong replaceability, and the ability to operate with the equipment without interference during subsequent automated processing. This is a technical problem that needs to be solved urgently. Utility Model Content

[0006] The purpose of the present invention is: to address the above-mentioned problems, the present invention provides a reagent kit receiving basket, which provides a reagent kit receiving basket. By setting the basket handle and the receiving part body as a detachable structure, the two can be assembled after high-precision processing separately. The reagent kit basket can be added to the automated processing instrument separately, and can also be integrated into an integrated reagent loading device for modular multi-group addition. When multiple groups are added, the position direction can be accurately judged by the opening direction of the handle gripping part. It has high versatility, and the detachable handle can be used to cooperate with the equipment for automated processing without interference.

[0007] The technical solutions adopted in this utility model are as follows:

[0008] A reagent box receiving basket, the receiving part body comprises a bottom plate, a detachable handle is embedded in the middle of the bottom plate, and the receiving part body forms two receiving cavities with the handle as a partition, and the receiving cavities are used to receive the reagent box.

[0009] Furthermore, a handle plug-in portion cooperating with the handle is provided in the middle of the bottom plate, and the handle is embedded in the handle plug-in portion.

[0010] Furthermore, the plug-in slot is arranged along the width direction of the base plate, and the two ends of the plug-in slot extend to the two side walls of the receiving part body respectively. The bottom of the handle is embedded in the plug-in slot along the side walls of the receiving part body, and the parts of the plug-in slot located on the two side walls are respectively set as directional and non-directional card slots, and the shapes of the two side edges of the handle match the directional and non-directional card slots.

[0011] Furthermore, a plurality of opposing engaging parts are provided at intervals along the width direction of the base plate on one side of the plug-in slot, and a plurality of latching grooves corresponding to the opposing engaging parts are provided at the bottom of the handle, and the latching grooves are used to engage the opposing engaging parts to lock the handle to the base plate.

[0012] Furthermore, a hollow grip portion is provided at one end of the handle away from the handle plug-in portion, and one side of the grip portion is open. The groove at the bottom of the handle is also a hollow structure, and the distances between the two grooves located at the head and tail and the end of the handle are different.

[0013] Furthermore, a plurality of bar-shaped reagent kit card blocks are embedded side by side in the two receiving cavities.

[0014] Furthermore, a pipe receiving block is embedded in each of the two receiving cavities, and a plurality of pipe connecting holes arranged in an array are provided in the pipe receiving block.

[0015] Furthermore, the connecting pipe hole includes at least two coaxial connecting pipe parts with diameters decreasing along the axial direction of the connecting pipe hole, and a transition platform is provided between two adjacent connecting pipe parts with different diameters.

[0016] The second technical solution of the present invention is an integrated reagent loading device, which adopts a reagent reagent receiving basket, including a loading body, wherein the loading body is provided with a plurality of receiving slots, one receiving slot corresponds to one reagent reagent receiving basket, and the opening direction of the handle holding portion in the multiple reagent reagent receiving baskets is consistent.

[0017] Furthermore, side guides are provided on both sides of the bottom of the loading body, and the integrated reagent loading device performs integrated loading through the side guides.

[0018] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are:

[0019] 1. The utility model relates to a test kit receiving basket. A basket handle is configured at the middle position of the receiving part body of the basket through a plug-in detachable connection method, so that the receiving part body and the handle can be formed separately using different processing technologies, and can be quickly spliced ​​through the detachable plug-in connection method. A gripping portion with a single-side opening is configured at the top of the handle so that the basket can be placed uniformly. The different materials of the handle and the body can adapt to the needs of different scenarios. The bottom of the handle includes a corresponding number of slots with multiple groups of opposing interlocking parts configured with the handle plug-in part, which makes the connection between the two more reliable. The slots are configured as hollow structures for easier processing.

[0020] 2. The reagent kit basket of the present invention can configure the receiving cavity of the receiving part body to form different types of card blocks or receiving block structures according to the shapes of different reagent kits, so that the basket can be adapted to receive long strip reagent kits or columnar reagent bottles respectively. In order to ensure that reagent bottles of different sizes can be reliably received, at least two coaxial and unequal diameter pipe connection parts with different extension depths are arranged in the depth direction of the tube receiving block structure. In this way, it can adapt to reagent bottles of different specifications from different manufacturers, thereby improving the efficiency of reagent loading.

[0021] 3. The present invention also discloses an integrated reagent loading device, which is equipped with a plurality of receiving slots, which can receive reagent kit baskets in a consistent direction according to the opening direction of the handle grip portion, and load reagent kits in batches and efficiently. The side guide portion configured at the bottom of the loading portion can simply and efficiently constrain the loading portion, making the loading operation more reliable and efficient. In a biological sample processing system, the device can be used to directly add reagents in batches without having to unload the reagent kits from the basket and add them individually. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a schematic diagram of the test kit receiving basket structure of Example 1 of the present utility model;

[0023] Figure 2 This is a schematic diagram of the structure in which the handle of the reagent box receiving basket and the main body of the receiving part are separated;

[0024] Figure 3 This is a cross-sectional view of the reagent kit receiving basket after assembly in Example 1 of the present utility model;

[0025] Figure 4 This is an exploded view of the reagent box basket carrying the strip reagent box in Example 1 of the present utility model;

[0026] Figure 5 This is a diagram of the state of the reagent box basket after carrying the strip reagent box in Example 1 of the present utility model;

[0027] Figure 6 This is a structural diagram of the reagent box basket carrying tube receiving block in Example 2 of the present utility model;

[0028] Figure 7 This is a state diagram of the reagent box basket carrying tube receiving block carrying different types of reagent bottles in Example 2 of the present utility model;

[0029] Figure 8 This is an exploded view of the reagent basket carrying tube receiving block carrying different types of reagent bottles in Example 2 of the present invention;

[0030] Figure 9 This is a cross-sectional view of the tube bearing block of the reagent kit basket in Example 2 of the present invention receiving different types of reagent bottles;

[0031] Figure 10 This is a state diagram of the integrated reagent loading device receiving several different reagent kits in Example 3 of the present utility model;

[0032] Figure 11 This is a state diagram of the integrated reagent loading device in Example 3 of the present utility model after receiving several different reagent kits;

[0033] Figure 12 This is a diagram of the coordination between the bottom side guide portion and the guide block of the integrated reagent loading device in Example 3 of the present invention.

[0034] Markings in the figure: 1-base plate, 2-handle plug-in part, 3-opposing fitting, 4-handle, 5-engaging groove, 6-long reagent box, 7-tube receiving block, 8-tube hole, 9-first reagent bottle, 10-second reagent bottle, 11-loading body, 12-receiving groove, 13-side guide part, 14-guide block, 15-gripping part. DETAILED DESCRIPTION

[0035] The present invention will be described in detail below with reference to the accompanying drawings.

[0036] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0037] Example 1

[0038] This embodiment provides a reagent box receiving basket, such as Figure 1 As shown, it includes a receiving part body, which is a groove-shaped structure with a predetermined depth. The groove-shaped structure is configured with a card block for matching the bar reagent kit. The bar reagent kit is received by the card block. The receiving part body is in the shape of an open rectangular parallelepiped or a quasi-rectangular parallelepiped. The receiving part body includes a bottom plate 1, and a handle plug-in portion 2 is provided in the middle of the bottom plate 1. The handle plug-in portion includes a plug-in slot. The plug-in slot is located in the middle of the bottom plate 1 and is arranged along the width direction of the basket. The two ends of the plug-in slot extend to the top of the two side walls of the receiving part body, as shown in FIG. Figure 2 and Figure 3The cam 2 of the handle 4 is fixed to the bottom of the handle 4 so that the handle 4 can be fixed to the handle 4 by the screw thread 21. The handle 4 is convenient to remove from the handle plug-in part 2, and the handle 4 can be easily removed from the handle plug-in part 2. The groove 5 is a hollow structure, which can diversify the processing procedures of the groove 5 and increase the dimensional accuracy of the molding. At the same time, due to the design of a detachable structure, the two can be independently processed and molded to adapt to different processing accuracy requirements. The detachable connection also makes it easier to replace and maintain the handle of the basket, and makes the cleaning and maintenance of the basket more convenient, the disinfection more thorough, and the risk of cross-contamination during long-term use is also lower. The top of the handle 4 is designed with a gripping portion 15 with an open side. This design gives the test kit basket a fool-proof operation feature. This design can clearly distinguish whether the loading direction of the basket is correct. In this embodiment, the materials of the handle 4 and the receiving part body are different. For example, the receiving part body is a non-metallic material, and the handle 4 is processed with a metal material. The receiving body can be injection molded with a non-metallic material with better injection molding properties. In this way, the processing cost is lower and the finished product precision is higher.

[0039] like Figure 4 and Figure 5As shown, the handle 4 divides the receiving part body into two receiving cavities. In this embodiment, the middle part of the bottom plate is selected as the plug-in point to plug the handle to form two receiving cavities with a symmetrical structure. The position of the handle can be adjusted and designed according to actual conditions. The size of the two receiving cavities formed is based on the size required for the actual application. In this embodiment, the two receiving cavities are respectively built-in with bar reagent box blocks, and the bar reagent box blocks undertake multiple bar reagent boxes. The application of long bar reagent boxes 6 in enzyme-linked immunosorbent assay is very extensive. For liquid reagents with large consumption, this type of reagent box is best used for loading. In this embodiment, the handle 4 can be plugged into the handle plug-in part 2 arranged in the middle of the bottom plate 1. At this time, multiple groups of opposing chimeric parts 3 can be locked to the bottom of the handle 4. The receiving part body includes a plurality of strip reagent box blocks distributed on both sides of the handle plug-in part 2. Here, the blocks are arranged in pairs on the side walls of the receiving part body in the width direction. Multiple strip reagent boxes are detachably clamped in the receiving part body. In this embodiment, the long strip reagent box 6 can be clamped in the groove of the basket receiving part body by an even number of blocks symmetrically distributed on both sides of the handle plug-in part 2. The even number of blocks can be 2, 4, 6, 8, etc. Here, the two ends of the long strip reagent box in the width direction are formed into a cylindrical structure, and the matching strip reagent box blocks also include an arc-shaped connecting surface, so that the long strip reagent box 6 can be efficiently and reliably stored in the basket.

[0040] Example 2

[0041] Example 2 replaces the function of the receiving cavity in Example 1; further explanation, the same parts are not repeated here, such as Figure 6-9As shown, the two receiving cavities of the reagent box receiving basket have built-in tube receiving blocks for receiving different types of reagent bottles. Reagents with smaller volumes added to the enzyme-linked immunosorbent assay are generally stored in cylindrical bottles, which can be a common form of small system reagent boxes that need to be added. The volumes of reagent bottles produced by different manufacturers vary greatly. In order to match the differences in reagent bottles in automated detection equipment, some equipment requires the operator to pour the reagents in the original reagent bottles into standard reagent bottles, and then add them to the automated detection equipment. This operation is highly complex, has redundant and inefficient work, and poses a risk of contamination to the operator. In this embodiment, the receiving part body also includes two tube receiving blocks 7 distributed on both sides of the handle plug-in part 2. The two tube receiving blocks 7 are configured with the same structure and are symmetrically and detachably installed in the groove of the receiving part body, that is, in the two receiving cavities. The tube receiving block 7 contains a plurality of connecting holes 8 arranged in an array. The number of connecting holes 8 here can be 4×6=24, or 4 ×8=32, or other forms of row and column arrangement. In one case, the connecting hole 8 can be arranged as a single aperture structure with a preset depth, so that it can accommodate reagent bottles of the same size. In another case, the connecting hole 8 can include at least two coaxial connecting parts with different diameters. Here, two coaxial connecting parts are taken as an example. Some holes of the arrayed connecting holes 8 accommodate the first reagent bottle 9 with a larger diameter, while the other holes accommodate the second reagent bottle 10 with a smaller diameter. The connecting part with a smaller diameter extends a greater distance in the tube receiving block 7 than the connecting part with a larger diameter. A transition platform is included between adjacent connecting parts of unequal diameters. The transition platform is used to confine the first reagent bottle 9 to the larger diameter connecting part above the transition platform, while the second reagent bottle 10 is constrained by the smaller diameter connecting part. Such a design enables the arrayed connecting holes 8 to reliably accommodate different types of reagent bottles, making the identification features more obvious and the control accuracy higher in subsequent operations.

[0042] Example 3

[0043] like Figure 10-12As shown, the present embodiment provides an integrated reagent loading device, including a loading body 11, which can be configured as a roughly rectangular structure. In order to ensure that its strength meets the requirements, the loading body 11 is processed using metal materials, such as stainless steel or alloy materials. A plurality of receiving slots 12 are provided on the loading body 11. The number of receiving slots 12 here can be no less than 2 and no more than 6 to ensure loading efficiency and reduce the operational difficulty of integrated loading. Each receiving slot 12 is configured with the same structure to make processing more convenient. An anti-reverse installation structure is also configured in each receiving slot 12. Each receiving slot 12 can detachably receive a fool-proof reagent kit receiving basket in Example 1 or Example 2, and the opening ends of the handle gripping portions 15 in the multiple reagent kit receiving baskets are oriented in the same direction, so that The operator can visually and autonomously restrain the installation of the reagent reagent receiving basket, and can also cooperate with the anti-reverse installation structure to achieve reliable physical restraint, so that the basket cannot be embedded in the receiving slot in the reverse state, which has a double protection effect. In this embodiment, the bottom of the loading main body 11 is also provided with an opposing side guide portion 13. In this embodiment, the cross-section of the side guide portion 13 is L-shaped. The automated detection system can be provided with a guide structure that cooperates with the side guide portion 13. Specifically, the system is provided with a plurality of relatively arranged guide blocks 14. The guide blocks 14 are configured as standard parts to make processing more convenient. The integrated reagent loading device can rely on the L-shaped cross-section side guide portion 13 to cooperate with the guide block 14, so that the integrated reagent loading device can be reliably pushed into place with low resistance, and its installation operation is also simpler.

[0044] Example 4

[0045] In this embodiment, the application of the above-mentioned embodiments in a biological sample processing system is provided, especially an ELISA enzyme-linked immunosorbent assay (ELISA) automatic detection system. The system includes a reagent receiving portion, which can receive the fool-proof reagent kit receiving baskets of Examples 1 and 2. The reagent kits are arranged in the reagent kit receiving baskets. The system also includes a sample tube receiving portion, which can accommodate multiple groups of sample tube racks. Here, the sample tube racks can be single-row sample tube racks, and each sample tube rack can contain 8, 9, 10, 11, 12, and so on, sample tubes. In combination with the integrated reagent loading portion of Example 3, all relevant reagents can be efficiently and quickly prepared at one time.

[0046] This document uses specific examples to illustrate the principles and implementation methods of the present invention. The above examples are only intended to help understand the method and core concept of the present invention. It should be noted that those skilled in the art can make various improvements and modifications to the present invention without departing from the principles of the present invention, and such improvements and modifications also fall within the scope of protection of the claims of the present invention.

[0047] In the description of the present invention, it should be noted that the terms "middle", "upper", "lower", "left", "right", "vertical", "horizontal", "inside", "outside", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, or are the orientations or positional relationships in which the product of the utility model is usually placed when in use. They are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, they cannot be understood as a limitation on the present invention.

[0048] It should also be noted that, in the description of this utility model, unless otherwise expressly specified or limited, the terms "disposed," "installed," "connected," and "connected" should be understood in a broad sense. For example, they can refer to fixed connections, detachable connections, or integral connections; mechanical connections, electrical connections; direct connections, indirect connections through an intermediate medium, and internal connections between two components. Those skilled in the art will understand the specific meanings of the above terms in this utility model based on the specific circumstances.

Claims

1. A reagent box receiving basket, characterized in that: The receiving part comprises a groove-type receiving part body, the receiving part body comprises a bottom plate, a detachable handle is embedded in the middle of the bottom plate, and the receiving part body forms two receiving cavities with the handle as a partition, and the receiving cavities are used to receive the reagent kit.

2. A reagent kit receiving basket according to claim 1, characterized in that: A handle plug-in portion cooperating with the handle is provided at the middle portion of the bottom plate, and the handle is embedded in the handle plug-in portion.

3. A reagent kit receiving basket according to claim 2, characterized in that: The handle plug-in portion includes a plug-in slot, which is arranged along the width direction of the base plate, and the two ends of the plug-in slot extend to the two side walls of the receiving part body respectively. The bottom of the handle is embedded in the plug-in slot along the side walls of the receiving part body, and the parts of the plug-in slot located on the two side walls are respectively set as directional and non-directional card slots, and the shapes of the two side edges of the handle match the directional and non-directional card slots.

4. A reagent kit receiving basket according to claim 3, characterized in that: A plurality of opposing engaging parts are provided at intervals along the width direction of the base plate on one side of the insertion slot, and a plurality of latching grooves corresponding to the opposing engaging parts are provided at the bottom of the handle, and the latching grooves are used to engage the opposing engaging parts to lock the handle to the base plate.

5. The reagent kit receiving basket according to claim 4, characterized in that: The handle is provided with a hollow gripping portion at one end away from the handle plug-in portion, and one side of the gripping portion is open. The groove at the bottom of the handle is also a hollow structure, and the distances between the two grooves located at the head and tail and the end of the handle are different.

6. The reagent kit receiving basket according to claim 1, characterized in that: A plurality of bar-shaped reagent kit card blocks are embedded side by side in the two receiving cavities.

7. The reagent kit receiving basket according to claim 1, characterized in that: A pipe receiving block is embedded in each of the two receiving cavities, and a plurality of pipe receiving holes arranged in an array are provided in the pipe receiving block.

8. The reagent kit receiving basket according to claim 7, characterized in that: The connecting pipe hole comprises at least two coaxial connecting pipe parts with diameters decreasing along the axial direction of the connecting pipe hole, and a transition platform is provided between two adjacent connecting pipe parts with different diameters.

9. An integrated reagent loading device, using a reagent kit receiving basket according to any one of claims 1 to 8, characterized in that: The loading body comprises a loading body provided with a plurality of receiving slots, one receiving slot correspondingly receiving a reagent box receiving basket, and the opening ends of the handle gripping parts in the plurality of reagent box receiving baskets face the same direction.

10. The integrated reagent loading device according to claim 9, characterized in that: Side guide parts are respectively provided on both sides of the bottom of the loading body, and the integrated reagent loading device performs integrated loading through the side guide parts.

Images