Automatic mobile phase supplementing device

Abstract

The utility model discloses an automatic mobile phase supplementing device which comprises a mobile phase supplementing tank, the top of the mobile phase supplementing tank is connected with a cleaning assembly, the outside of the mobile phase supplementing tank is connected with a temperature adjusting assembly, and the top of the mobile phase supplementing tank is connected with a mobile phase pretreatment assembly. A cleaning assembly is arranged, cleaning liquid is added into a cleaning liquid box through a water injection pipe, a first water pump is matched with a first water pumping pipe to pump the cleaning liquid to a first water outlet pipe, then the cleaning liquid enters an annular pipe and finally enters flow dividing pipes to be sprayed out of a plurality of high-pressure spray heads, three high-pressure spray heads are installed on each flow dividing pipe, and the directions of the three high-pressure spray heads are different. Therefore, the residual mobile phase on the inner wall of the mobile phase supplement tank can be flushed and cleaned as comprehensively as possible, cross contamination and difficulty in guaranteeing experiment safety and data reliability are prevented, and after cleaning, the drainage valve is opened, and waste liquid is discharged from the drainage pipe.

Description

Technical Field

[0001] The utility model relates to the field of mobile phase replenishing devices, in particular to an automatic mobile phase replenishing device. Background Art

[0002] The mobile phase replenishment device is a type of laboratory equipment, mainly used to automatically add, replenish or replace the mobile phase medium in liquid chromatography, gas chromatography, mass spectrometry and other analytical techniques that require the use of mobile phase. The mobile phase is a very critical component in such analytical techniques. It not only carries the sample through the separation column, but also affects the separation efficiency and the accuracy of the analysis results.

[0003] Application number: CN202021435519.X, discloses a device for replenishing mobile phase, which stirs the mobile phase through a stirring mechanism to prevent the mobile phase from settling, pressurizes the mobile phase through a pressurized water pump, replenishes the mobile phase through a feed port, prevents dust from entering the mobile phase storage box through a first control valve, and prevents the mobile phase from volatilizing. The remaining amount of mobile phase in the device box can be monitored by a liquid level detector;

[0004] However, due to the different types of mobile phases, the existing mobile phase replenishment device is difficult to clean one mobile phase in time and replenish another mobile phase after it is used up. Therefore, cross contamination may occur, making it difficult to ensure experimental safety and data reliability. For this reason, we propose an automatic mobile phase replenishment device. Utility Model Content

[0005] In order to overcome the shortcomings of the prior art, the purpose of the present invention is to provide an automatic mobile phase replenishment device. By setting a cleaning component, cleaning liquid is added to the cleaning liquid tank through a water injection pipe. A water pump cooperates with a water suction pipe to draw the cleaning liquid to an outlet pipe, and then enters an annular pipe and finally enters a diversion pipe to be sprayed out from multiple high-pressure nozzles. Three high-pressure nozzles are installed on each diversion pipe, and the directions of the three high-pressure nozzles are inconsistent. Therefore, the mobile phase remaining on the inner wall of the mobile phase replenishment tank can be flushed and cleaned as comprehensively as possible to prevent cross contamination, which makes it difficult to ensure experimental safety and data reliability. After cleaning, open the drain valve and discharge the waste liquid from the drain pipe.

[0006] The above technical objectives of the present invention are achieved through the following technical solutions:

[0007] An automatic mobile phase replenishment device comprises a mobile phase replenishment tank, a cleaning component is connected to the top of the mobile phase replenishment tank, a temperature adjustment component is connected to the outside of the mobile phase replenishment tank, and a mobile phase pretreatment component is connected to the top of the mobile phase replenishment tank;

[0008] The cleaning assembly includes a cleaning liquid tank, the upper end of the cleaning liquid tank is fixedly connected to a water injection pipe, the upper end of the cleaning liquid tank is fixedly connected to a water pump, the water inlet end of the water pump is fixedly connected to a water suction pipe, the water outlet end of the water pump is threadedly connected to a water outlet pipe, the upper end of the mobile phase replenishing tank is connected to a sealing cover, the external thread of the sealing cover is connected to a screw, the screw is threadedly connected to the mobile phase replenishing tank, the water outlet pipe passes through the sealing cover and is fixedly connected to the sealing cover, the lower end of the water outlet pipe is fixedly connected to an annular pipe, the lower end of the annular pipe is fixedly connected to a plurality of diversion pipes, the outside of the plurality of diversion pipes are fixedly connected to a plurality of high-pressure nozzles, the lower end of the mobile phase replenishing tank is fixedly connected to a drain pipe, and the outside of the drain pipe is fixedly connected to a drain valve.

[0009] By setting up a cleaning component, cleaning liquid is added to the cleaning liquid tank through the water injection pipe. The water pump cooperates with the water suction pipe to draw the cleaning liquid to the water outlet pipe, then enters the annular pipe, and finally enters the diversion pipe and is sprayed out from multiple high-pressure nozzles. Each diversion pipe is equipped with three high-pressure nozzles, and the directions of the three high-pressure nozzles are inconsistent. Therefore, the mobile phase remaining on the inner wall of the mobile phase replenishment tank can be flushed and cleaned as comprehensively as possible to prevent cross contamination, which makes it difficult to ensure experimental safety and data reliability. After cleaning, open the drain valve and discharge the waste liquid from the drain pipe.

[0010] Furthermore, the temperature regulating assembly includes a temperature sensor, which is fixedly connected to the upper end of the sealing cover. The detection head of the temperature sensor passes through the sealing cover and extends to the interior of the mobile phase replenishment tank.

[0011] By providing a temperature sensor, the temperature inside the mobile phase replenishment tank can be detected, so that the temperature inside the mobile phase replenishment tank can be adjusted according to different properties of different mobile phases.

[0012] Furthermore, the outside of the mobile phase replenishment tank is fixedly connected to a connecting sleeve, the left end of the connecting sleeve is fixedly connected to a liquid inlet pipe, the outside of the liquid inlet pipe is fixedly connected to a liquid inlet valve, the inside of the connecting sleeve is fixedly connected to a coil, the coil is fixedly connected to the liquid inlet pipe, the left end of the connecting sleeve is fixedly connected to a liquid outlet pipe, the outside of the liquid outlet pipe is fixedly connected to a liquid outlet valve, and the coil is fixedly connected to the liquid outlet pipe.

[0013] Furthermore, the mobile phase pretreatment component includes a liquid level meter, which is fixedly connected to the upper end of the sealing cover. The detection probe of the liquid level meter passes through the sealing cover and extends to the interior of the mobile phase replenishment tank. The upper end of the sealing cover is fixedly connected to a controller, and the controller is electrically connected to the liquid level meter.

[0014] Furthermore, the upper end of the sealing cover is fixedly connected to a pretreatment tank, the upper end of the pretreatment tank is fixedly connected to a water injection pipe 2, the upper end of the pretreatment tank is fixedly connected to a drive motor, the lower end of the output end of the drive motor is fixedly connected to a stirring shaft, the stirring shaft is rotatably connected to the pretreatment tank, and the outside of the stirring shaft is fixedly connected to a stirring blade.

[0015] Furthermore, a second water pump is fixedly connected to the upper end of the sealing cover, and the second water pump is electrically connected to the controller.

[0016] Furthermore, the water inlet end of the second water pump is fixedly connected to a second water pumping pipe, and the second water pumping pipe is fixedly connected to the pretreatment tank.

[0017] Furthermore, the water outlet end of the second water pump is fixedly connected to a second water outlet pipe, the second water outlet pipe passes through the sealing cover and is fixedly connected to the sealing cover, and the second water outlet pipe extends to the interior of the mobile phase replenishment tank.

[0018] In summary, the present invention has the following beneficial effects:

[0019] 1. By setting up a cleaning component, add cleaning liquid to the cleaning liquid tank through the water injection pipe. The water pump cooperates with the water extraction pipe to pump the cleaning liquid to the water outlet pipe. Then it enters the annular pipe and finally enters the diversion pipe and is sprayed from multiple high-pressure nozzles. Each diversion pipe is equipped with three high-pressure nozzles. The directions of the three high-pressure nozzles are inconsistent. Therefore, the residual mobile phase on the inner wall of the mobile phase replenishment tank can be rinsed and cleaned as comprehensively as possible to prevent cross contamination and difficulty in ensuring experimental safety and data reliability. After cleaning, open the drain valve and discharge the waste liquid from the drain pipe.

[0020] 2. By setting a temperature sensor, the temperature inside the mobile phase replenishment tank can be detected, so that the temperature inside the mobile phase replenishment tank can be adjusted according to the different properties of different mobile phases. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 Schematic diagram of the overall structure of this embodiment;

[0022] Figure 2 Schematic diagram of the structure of the sealing cover in this embodiment;

[0023] Figure 3 Schematic diagram of the structure of the cleaning component in this embodiment;

[0024] Figure 4 Schematic diagram of the structure of the drain pipe in this embodiment;

[0025] Figure 5 Schematic diagram of the structure of the coil in this embodiment;

[0026] Figure 6Schematic diagram of the structure of the stirring blade in this embodiment.

[0027] In the figure, 1. Mobile phase replenishment tank; 2. Cleaning assembly; 201. Cleaning liquid tank; 202. Water injection pipe 1; 203. Water pump 1; 204. Water extraction pipe 1; 205. Water outlet pipe 1; 206. Sealing cover; 207. Screw; 208. Ring pipe; 209. Diverter pipe; 210. High-pressure nozzle; 211. Drain pipe; 212. Drain valve; 3. Temperature adjustment assembly; 301. Temperature sensor; 302 , connecting sleeve; 303, liquid inlet pipe; 304, liquid inlet valve; 305, coil; 306, liquid outlet pipe; 307, liquid outlet valve; 4, mobile phase pretreatment component; 401, liquid level meter; 402, controller; 403, pretreatment tank; 404, water injection pipe 2; 405, drive motor; 406, stirring shaft; 407, stirring blade; 408, water pump 2; 409, water suction pipe 2; 410, water outlet pipe 2. DETAILED DESCRIPTION

[0028] The present invention will be described in further detail below with reference to the accompanying drawings.

[0029] Identical components are denoted by the same reference numerals. It should be noted that the terms "front," "rear," "left," "right," "upper," and "lower" used in the following description refer to directions in the accompanying drawings, and the terms "bottom," "top," "inner," and "outer" refer to directions toward or away from the geometric center of a particular component, respectively.

[0030] Reference Figure 1 As shown, an automatic mobile phase replenishing device in a preferred embodiment of the present utility model includes a mobile phase replenishing tank 1, a cleaning component 2 is connected to the top of the mobile phase replenishing tank 1, a temperature regulating component 3 is connected to the outside of the mobile phase replenishing tank 1, and a mobile phase pretreatment component 4 is connected to the top of the mobile phase replenishing tank 1;

[0031] Reference Figure 1-Figure 4As shown, the cleaning component 2 includes a cleaning liquid tank 201, the upper end of the cleaning liquid tank 201 is fixedly connected to a water injection pipe 202, the upper end of the cleaning liquid tank 201 is fixedly connected to a water pump 203, the water inlet end of the water pump 203 is fixedly connected to a water extraction pipe 204, the water outlet end of the water pump 203 is threadedly connected to a water outlet pipe 205, the upper end of the mobile phase replenishment tank 1 is connected to a sealing cover 206, the outer surface of the sealing cover 206 is threadedly connected to a screw 207, and the screw 207 is connected to the The mobile phase replenishing tank 1 is threadedly connected, and the water outlet pipe 205 passes through the sealing cover 206 and is fixedly connected to the sealing cover 206. The lower end of the water outlet pipe 205 is fixedly connected to an annular pipe 208, and the lower end of the annular pipe 208 is fixedly connected to multiple diversion pipes 209. The outside of the multiple diversion pipes 209 is fixedly connected to multiple high-pressure nozzles 210. The lower end of the mobile phase replenishing tank 1 is fixedly connected to a drain pipe 211, and the outside of the drain pipe 211 is fixedly connected to a drain valve 212.

[0032] By setting up a cleaning component 2, cleaning liquid is added to the cleaning liquid tank 201 through the water injection pipe 202, and the water pump 203 cooperates with the water suction pipe 204 to draw the cleaning liquid to the water outlet pipe 205, and then enters the annular pipe 208, and finally enters the diversion pipe 209, and is sprayed out from multiple high-pressure nozzles 210. Each diversion pipe 209 is equipped with three high-pressure nozzles 210, and the directions of the three high-pressure nozzles 210 are inconsistent. Therefore, the mobile phase remaining on the inner wall of the mobile phase replenishment tank 1 can be rinsed and cleaned as comprehensively as possible to prevent cross contamination, which makes it difficult to ensure experimental safety and data reliability. After cleaning, open the drain valve 212 and discharge the waste liquid from the drain pipe 211.

[0033] Reference Figure 1 、 Figure 2 and Figure 5 As shown, the temperature regulating assembly 3 includes a temperature sensor 301 , which is fixedly connected to the upper end of the sealing cover 206 . The detection head of the temperature sensor 301 passes through the sealing cover 206 and extends to the interior of the mobile phase replenishing tank 1 .

[0034] By providing the temperature sensor 301 , the temperature inside the mobile phase replenishing tank 1 can be detected, so that the temperature inside the mobile phase replenishing tank 1 can be adjusted according to different properties of the mobile phase.

[0035] Reference Figure 1 、 Figure 2 and Figure 5As shown, the outside of the mobile phase replenishment tank 1 is fixedly connected to a connecting sleeve 302, the left end of the connecting sleeve 302 is fixedly connected to a liquid inlet pipe 303, the outside of the liquid inlet pipe 303 is fixedly connected to a liquid inlet valve 304, the inside of the connecting sleeve 302 is fixedly connected to a coil 305, the coil 305 is fixedly connected to the liquid inlet pipe 303, the left end of the connecting sleeve 302 is fixedly connected to a liquid outlet pipe 306, the outside of the liquid outlet pipe 306 is fixedly connected to a liquid outlet valve 307, and the coil 305 is fixedly connected to the liquid outlet pipe 306.

[0036] By setting up the coil 305, when it is necessary to adjust the temperature inside the mobile phase replenishment tank 1, select a suitable cooling medium or heating medium, connect the liquid inlet pipe 303 to the liquid delivery pump body, open the liquid inlet valve 304, and deliver the medium to the coil 305, so that the temperature inside the mobile phase replenishment tank 1 can be adjusted, and open the drain valve to discharge the medium from the drain pipe.

[0037] Reference Figure 1 、 Figure 2 and Figure 6 As shown, the mobile phase pretreatment component 4 includes a liquid level meter 401, which is fixedly connected to the upper end of the sealing cover 206. The detection probe of the liquid level meter 401 passes through the sealing cover 206 and extends to the interior of the mobile phase replenishment tank 1. The upper end of the sealing cover 206 is fixedly connected to a controller 402, and the controller 402 is electrically connected to the liquid level meter 401.

[0038] By providing a liquid level meter 401 , the liquid level of the mobile phase inside the mobile phase replenishing tank 1 can be detected, and the information can be transmitted to the controller 402 .

[0039] Reference Figure 1 、 Figure 2 and Figure 6 As shown, the upper end of the sealing cover 206 is fixedly connected to the pretreatment tank 403, the upper end of the pretreatment tank 403 is fixedly connected to the water injection pipe 2 404, the upper end of the pretreatment tank 403 is fixedly connected to the drive motor 405, the lower end of the output end of the drive motor 405 is fixedly connected to the stirring shaft 406, the stirring shaft 406 is rotatably connected to the pretreatment tank 403, and the outside of the stirring shaft 406 is fixedly connected to the stirring blade 407.

[0040] The driving motor 405 drives the stirring shaft 406 and the stirring blade 407 to rotate, thereby pre-treating the mobile phase inside the pre-treatment tank 403 to fully mix it and prevent precipitation.

[0041] Reference Figure 1 、 Figure 2 and Figure 6 As shown, the upper end of the sealing cover 206 is fixedly connected to the water pump 2 408 , and the water pump 2 408 is electrically connected to the controller 402 .

[0042] Reference Figure 1 As shown, the water inlet end of the second water pump 408 is fixedly connected to the second pumping pipe 409 , and the second pumping pipe 409 is fixedly connected to the pretreatment tank 403 .

[0043] Reference Figure 1 、 Figure 2 and Figure 6 As shown, the water outlet end of the second water pump 408 is fixedly connected to the second water outlet pipe 410 , which passes through the sealing cover 206 and is fixedly connected to the sealing cover 206 , and extends to the interior of the mobile phase replenishment tank 1 .

[0044] When the liquid level reaches the lowest threshold, the controller 402 controls to turn on the water pump 2 408 , and the water pump 2 408 extracts the pretreated mobile phase and discharges it into the mobile phase replenishing tank 1 through the outlet pipe 2 410 to replenish the mobile phase in the mobile phase replenishing tank 1 .

[0045] Specific implementation process: Use the water injection pipe 404 to add mobile phase to the pretreatment tank 403, and drive the motor 405 to drive the stirring shaft 406 and the stirring blade 407 to rotate, so as to pretreat the mobile phase in the pretreatment tank 403 and fully mix it to prevent precipitation;

[0046] The liquid level meter 401 is then used to detect the liquid level of the mobile phase in the mobile phase replenishment tank 1 and transmit the information to the controller 402. When the liquid level reaches the minimum threshold, the controller 402 controls the opening of the second water pump 408. The second water pump 408 extracts the pretreated mobile phase and discharges it into the mobile phase replenishment tank 1 through the second outlet pipe 410, thereby replenishing the mobile phase in the mobile phase replenishment tank 1.

[0047] The temperature sensor 301 is used to detect the temperature inside the mobile phase replenishment tank 1, so that the temperature inside the mobile phase replenishment tank 1 can be adjusted according to the different properties of different mobile phases. When the temperature inside the mobile phase replenishment tank 1 needs to be adjusted, a suitable cooling medium or heating medium is selected, the liquid inlet pipe 303 is connected to the liquid delivery pump body, the liquid inlet valve 304 is opened, and the medium is delivered to the coil 305, so that the temperature inside the mobile phase replenishment tank 1 can be adjusted. The liquid discharge valve is opened to discharge the medium from the liquid discharge pipe;

[0048] In addition, when the mobile phase replenishing tank 1 needs to be cleaned, cleaning liquid is added to the cleaning liquid tank 201 through the water injection pipe 202, and the water pump 203 cooperates with the water suction pipe 204 to draw the cleaning liquid to the water outlet pipe 205, and then enters the annular pipe 208, and finally enters the diversion pipe 209, and is sprayed out from multiple high-pressure nozzles 210. Each diversion pipe 209 is equipped with three high-pressure nozzles 210, and the directions of the three high-pressure nozzles 210 are inconsistent. Therefore, the mobile phase remaining on the inner wall of the mobile phase replenishing tank 1 can be rinsed and cleaned as comprehensively as possible to prevent cross contamination, which makes it difficult to ensure experimental safety and data reliability. After cleaning, open the drain valve 212 and discharge the waste liquid from the drain pipe 211.

[0049] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions are merely illustrative of the principles of the present invention. Various changes and improvements may be made to the present invention without departing from the spirit and scope of the present invention. Such changes and improvements are intended to fall within the scope of the present invention. The scope of protection claimed in this invention is defined by the appended claims and their equivalents.

Claims

1. An automatic mobile phase replenishment device, characterized in that: The mobile phase replenishing tank (1) comprises a mobile phase replenishing tank (1), the top of the mobile phase replenishing tank (1) is connected to a cleaning component (2), the outside of the mobile phase replenishing tank (1) is connected to a temperature regulating component (3), and the top of the mobile phase replenishing tank (1) is connected to a mobile phase pretreatment component (4); The cleaning assembly (2) comprises a cleaning liquid tank (201), the upper end of the cleaning liquid tank (201) is fixedly connected to a water injection pipe (202), the upper end of the cleaning liquid tank (201) is fixedly connected to a water pump (203), the water inlet end of the water pump (203) is fixedly connected to a water extraction pipe (204), the water outlet end of the water pump (203) is threadedly connected to a water outlet pipe (205), the upper end of the mobile phase replenishing tank (1) is connected to a sealing cover (206), the outer surface of the sealing cover (206) is threadedly connected to a screw (207), and the screw (207) The mobile phase replenishing tank (1) is threadedly connected to the water outlet pipe (205), which passes through the sealing cover (206) and is fixedly connected to the sealing cover (206). The lower end of the water outlet pipe (205) is fixedly connected to an annular tube (208), and the lower end of the annular tube (208) is fixedly connected to a plurality of diversion tubes (209). The outsides of the plurality of diversion tubes (209) are fixedly connected to a plurality of high-pressure nozzles (210). The lower end of the mobile phase replenishing tank (1) is fixedly connected to a drain pipe (211), and the outside of the drain pipe (211) is fixedly connected to a drain valve (212).

2. An automatic mobile phase replenishing device according to claim 1, characterized in that: The temperature regulating assembly (3) includes a temperature sensor (301), which is fixedly connected to the upper end of the sealing cover (206). The detection head of the temperature sensor (301) passes through the sealing cover (206) and extends to the interior of the mobile phase replenishment tank (1).

3. An automatic mobile phase replenishing device according to claim 2, characterized in that: The outside of the mobile phase replenishing tank (1) is fixedly connected to a connecting sleeve (302), the left end of the connecting sleeve (302) is fixedly connected to a liquid inlet pipe (303), the outside of the liquid inlet pipe (303) is fixedly connected to a liquid inlet valve (304), the inside of the connecting sleeve (302) is fixedly connected to a coil (305), the coil (305) is fixedly connected to the liquid inlet pipe (303), the left end of the connecting sleeve (302) is fixedly connected to a liquid outlet pipe (306), the outside of the liquid outlet pipe (306) is fixedly connected to a liquid outlet valve (307), and the coil (305) is fixedly connected to the liquid outlet pipe (306).

4. An automatic mobile phase replenishing device according to claim 1, characterized in that: The mobile phase pretreatment component (4) includes a liquid level meter (401), which is fixedly connected to the upper end of the sealing cover (206), and a detection probe of the liquid level meter (401) passes through the sealing cover (206) and extends to the interior of the mobile phase replenishment tank (1). The upper end of the sealing cover (206) is fixedly connected to a controller (402), and the controller (402) is electrically connected to the liquid level meter (401).

5. An automatic mobile phase replenishing device according to claim 4, characterized in that: The upper end of the sealing cover (206) is fixedly connected to a pretreatment tank (403), the upper end of the pretreatment tank (403) is fixedly connected to a second water injection pipe (404), the upper end of the pretreatment tank (403) is fixedly connected to a drive motor (405), the lower end of the output end of the drive motor (405) is fixedly connected to a stirring shaft (406), the stirring shaft (406) is rotatably connected to the pretreatment tank (403), and the outside of the stirring shaft (406) is fixedly connected to a stirring blade (407).

6. An automatic mobile phase replenishing device according to claim 5, characterized in that: The upper end of the sealing cover (206) is fixedly connected to a second water pump (408), and the second water pump (408) is electrically connected to the controller (402).

7. An automatic mobile phase replenishing device according to claim 6, characterized in that: The water inlet end of the second water pump (408) is fixedly connected to a second water pumping pipe (409), and the second water pumping pipe (409) is fixedly connected to the pretreatment tank (403).

8. An automatic mobile phase replenishing device according to claim 7, characterized in that: The water outlet end of the second water pump (408) is fixedly connected to the second water outlet pipe (410), and the second water outlet pipe (410) passes through the sealing cover (206) and is fixedly connected to the sealing cover (206), and the second water outlet pipe (410) extends to the interior of the mobile phase replenishment tank (1).

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