Exhaust structure and reagent tray

Abstract

The utility model discloses an exhaust structure and a reagent disc. The exhaust structure comprises a first channel arranged on a reagent disc base, a through hole formed in a reagent disc pasting film and a second channel connected to a covering part on the reagent disc pasting film. The first channel is communicated with a reaction hole in the reagent disc base; the first channel, the through hole and the second channel are communicated with one another to form an exhaust channel; the first channel is located below the second channel, and the second channel is higher than an annular liquid flow channel arranged on the reagent disc; a buffer groove communicated with the first channel is formed in the reagent disc base and is aligned with the through hole. In actual use, the exhaust purpose can be achieved without using a molecular plug, and the assembling difficulty of the reagent disc can be effectively reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of reagent disks for biochemical analyzers, in particular to an exhaust structure and a reagent disk. Background Art

[0002] A microfluidic biochemical assay plate is an experimental platform for biochemical analysis that combines microfluidics with the unique properties of biochemical reagent reactions. It typically uses microfabrication techniques to create tiny channels, sample loading chambers, mixing chambers, and reaction chambers on a microchip. Liquid samples to be tested are placed in the assay plate, which is then placed on a biochemical analyzer and subjected to centrifugal rotation to produce plasma or serum samples. Microfluidic biochemical assay plates enable high-throughput biochemical analysis of trace samples. Due to their numerous advantages, including rapid analysis, multiple parallel analyses, and high sensitivity and accuracy, they are the most commonly used liquid analysis instruments in laboratories.

[0003] The invention patent with authorization announcement number: CN117233412B discloses a microfluidic biochemical reagent disc and a biochemical test analysis method, which relates to the field of biochemical analysis instruments. It includes a disc body, a disc cover, a sample addition chamber, a diluent quantitative chamber, a sample quantitative chamber, a mixing chamber, an anti-backflow chamber, an annular channel, a reaction chamber and an annular channel; the anti-backflow chamber is connected and arranged on the disc body between the mixing chamber and the sample quantitative chamber, and is used to connect the mixing chamber with the sample quantitative chamber and to prevent the mixed liquid in the mixing chamber from flowing back into the sample quantitative chamber; the anti-backflow component is installed between the reaction chamber and the annular channel, and is used to prevent the liquid sample entering the reaction chamber from entraining the reaction reagent pre-installed in the reaction chamber and flowing back into the annular channel.

[0004] The invention with publication number CN118218939A discloses a reagent tray plunger loading device and method, belonging to the field of reagent tray assembly technology. The device includes a frame, which is used to be installed on the operating table of the reagent tray assembly equipment, and also includes a plunger loading assembly arranged on the frame. The plunger loading assembly includes a loading mechanism installed on the frame and a plunger pressing assembly arranged on the frame below the loading mechanism; the plunger pressing assembly includes a bracket, a driving mechanism, a push rod and a plunger adjustment assembly. The bracket is used to be installed on the reagent tray assembly equipment, the driving mechanism and the plunger adjustment assembly are installed on the bracket, and the push rod is connected to the driving mechanism and is located above the plunger adjustment assembly. The present invention is mainly used to realize the automatic loading and pressing of the plunger of a reagent tray with a plunger structure, realize the purpose of automatic assembly of the plunger, can effectively reduce the burden on workers, improve assembly efficiency and reduce the situation of missing plungers, and improve the overall yield rate of the reagent tray.

[0005] The existing molecular plug is used to block the exhaust channel to achieve the purpose of exhaust in actual use. However, it is found that the molecular plug is small in size, and the requirement for placing the molecular plug in the production process is high, thereby increasing the assembly difficulty. Content of the utility model

[0006] The utility model discloses a kind of exhaust structure and reagent disc, which can achieve the purpose of exhaust without using molecular plug in actual use, reduce the assembly difficulty of reagent disc.

[0007] To solve the above technical problems, the technical scheme adopted by the utility model is:

[0008] An exhaust structure includes a first channel provided on a reagent disc base, a through hole provided on a reagent disc film, and a second channel connected to a cover on the reagent disc film.

[0009] The first channel is in communication with a reaction hole on the reagent disc base. The first channel, the through hole and the second channel are in communication with each other to form an exhaust channel.

[0010] The first channel is located below the second channel, and the height of the second channel is higher than the height of the annular liquid flow channel provided on the reagent disc.

[0011] Further, in some preferred embodiments, a buffer groove is provided on the reagent disc base in communication with the first channel, and the buffer groove is aligned with the through hole.

[0012] Further, in some preferred embodiments, the buffer groove is a circular groove, a square groove or a special-shaped groove.

[0013] Further, in some preferred embodiments, the cross-sectional area of the buffer groove is larger than the cross-sectional area of the through hole.

[0014] Further, in some preferred embodiments, the cover is a stop ring or an upper film provided on the reagent disc film.

[0015] Further, in some preferred embodiments, the second channel is a groove provided on the stop ring.

[0016] Further, in some preferred embodiments, the second channel is a channel formed by removing the adhesive layer from the upper film.

[0017] Further, in some preferred embodiments, the width of the second channel is 0.1-3mm.

[0018] Further, in some preferred embodiments, the width of the second channel is 0.3mm.

[0019] The utility model also discloses a reagent tray, which comprises the above-mentioned exhaust structure.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] The utility model achieves the purpose of exhaust by providing a second channel on the cover of the reagent disc film and a first channel on the reagent disc base. Because the first channel is located below the second channel and the height of the second channel is higher than the height of the annular liquid flow channel provided on the reagent disc, the height of the first channel can be lower than the second channel, so that the liquid can be buffered at the through hole and avoid liquid leakage during the exhaust process. The utility model reduces the loading and assembly steps of the molecular plug during the actual assembly process, which can effectively improve assembly efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following is a brief introduction to the drawings required for use in the embodiments. It should be understood that the following drawings only show certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying any creative work.

[0023] Figure 1 This is a schematic diagram of the overall structure of the circular reagent tray of the present invention.

[0024] Figure 2 For this utility model Figure 1 It is a half-section view.

[0025] Figure 3 For this utility model Figure 2 A partial enlarged schematic diagram of point A in the middle.

[0026] Figure 4 This is a schematic diagram of the overall structure of the sector-shaped reagent tray of the present invention.

[0027] Figure 5 For this utility model Figure 4 Half-section view.

[0028] Reference numerals:

[0029] 101 base, 102 first channel, 103 film, 104 second channel, 105 reaction hole, 106 through hole, 107 annular liquid flow channel, 109 retaining ring, 110 upper film. DETAILED DESCRIPTION

[0030] Hereinafter, only certain exemplary embodiments are briefly described. As will be appreciated by those skilled in the art, the described embodiments may be modified in various ways without departing from the spirit or scope of the embodiments of the present invention. Therefore, the drawings and description are to be regarded as illustrative in nature and not restrictive.

[0031] In the description of the embodiments of the present invention, it should be understood that the terms "length", "vertical", "horizontal", "top", "bottom", etc. indicating the orientation or position relationship are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the embodiments of the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the embodiments of the present invention.

[0032] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be understood to indicate or imply relative importance or implicitly specify the number of the technical features indicated. Thus, features defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the embodiments of the present invention, "plurality" means two or more, unless otherwise specifically defined.

[0033] In the embodiments of the present invention, unless otherwise expressly specified or limited, the terms "installed," "connected," "connected," "fixed," etc. should be understood in a broad sense. For example, they can refer to fixed connection, detachable connection, or integration; mechanical connection, electrical connection, or communication; direct connection or indirect connection through an intermediate medium; internal communication between two components or interaction between two components. Those skilled in the art can understand the specific meanings of the above terms in the embodiments of the present invention based on specific circumstances.

[0034] In the embodiments of the present invention, unless otherwise expressly specified or limited, a first feature being "above" or "below" a second feature may include the first and second features being in direct contact, or may include the first and second features being in contact not directly but through another feature between them. Moreover, a first feature being "above," "above," and "above" a second feature includes the first feature being directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below," "below," and "below" a second feature includes the first feature being directly above and obliquely above the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0035] The disclosure below provides many different embodiments or examples for implementing different structures of the embodiments of the present invention. In order to simplify the disclosure of the embodiments of the present invention, the components and settings of specific examples are described below. Of course, these are merely examples and are not intended to limit the embodiments of the present invention. In addition, the embodiments of the present invention may repeat reference numbers and / or reference letters in different examples. Such repetition is for the purpose of simplicity and clarity and does not in itself indicate the relationship between the various embodiments and / or settings discussed.

[0036] The embodiments of the present invention are described in detail below with reference to the accompanying drawings.

[0037] See Figures 1-5 , this embodiment discloses an exhaust structure, including a first channel 102 provided on a reagent disc base 101, a through hole 106 provided on a reagent disc film 103, and a second channel 104 on a cover connected to the reagent disc film 103;

[0038] The first channel 102 is connected to the reaction hole 105 on the reagent disk base 101; the first channel 102, the through hole 106 and the second channel 104 are connected to each other to form an exhaust channel;

[0039] The first channel 102 is located below the second channel 104 , and the height of the second channel 104 is higher than the height of the annular liquid flow channel 107 provided on the reagent disk.

[0040] The present invention achieves the purpose of exhaust by providing a second channel 104 on the cover of the reagent disc film 103 and a first channel 102 on the reagent disc base 101. Since the first channel 102 is located below the second channel 104 and the height of the second channel 104 is higher than the height of the annular liquid flow channel 107 provided on the reagent disc, the height of the first channel 102 can be lower than the second channel 104, so that the liquid can be buffered at the through hole 106, thereby preventing liquid leakage during the exhaust process. The present invention reduces the loading and assembly steps of the molecular plug during the actual assembly process, which can effectively improve assembly efficiency.

[0041] Further, in some preferred embodiments, first channel 102 is greater than second channel 104 to reagent disk center distance to reagent disk center distance, and second channel 104 to reagent disk center minimum distance is less than the annular liquid channel 107 that is provided with on reagent disk to reagent disk center distance.Can make reagent disk when high speed rotation like this, liquid under centrifugal force, liquid flows to the place away from reagent disk center of circle half, second channel 104 farthest ends to reagent disk center distance is greater than annular liquid channel 107 to reagent disk center distance, so liquid can not overflow and air can be drained.Further, reagent disk base 101 is provided with the buffer tank that is communicated with first channel 102, and described buffer tank is aligned with through hole 106.The effect of liquid buffering can be improved by the buffer tank that is provided with, after the reagent in reaction well 105 enters first channel 102 inside, the buffer tank that is provided with on base 101 can play good buffering to reagent, avoids the situation that reagent overflows.

[0042] In actual use, the buffer groove is a circular groove, a square groove or a special-shaped groove.

[0043] Furthermore, in actual use, the cross-sectional area of ​​the buffer tank is larger than the cross-sectional area of ​​the through hole 106 , and a storage cavity structure with a small top and a large bottom can be formed at the position of the buffer tank and the through hole 106 , effectively preventing the leakage of reagents.

[0044] The covering member is a retaining ring 109 or an upper film 110 provided on the reagent disc film 103 .

[0045] In actual use, the reagent disc base 101 is a circular or fan-shaped structure. When the reagent disc base 101 is circular, the reagent disc film 103 is bonded to the retaining ring 109; when the reagent disc base 101 is fan-shaped, the reagent disc film 103 is bonded to the upper film 110.

[0046] Furthermore, the second channel 104 is a groove provided on the retaining ring 109 .

[0047] In actual use, the second channel 104 is a channel formed after the adhesive layer of the upper film 110 is removed.

[0048] Furthermore, the width of the second channel 104 is 0.1-3 mm.

[0049] In this embodiment, the width of the second channel 104 is 0.3 mm.

[0050] This embodiment further discloses a reagent tray, which is a circular reagent tray or a fan-shaped reagent tray; the reagent tray includes the exhaust structure described above.

[0051] Although the preferred embodiments of the present invention have been described, those skilled in the art may make additional changes and modifications to these embodiments once they have learned the basic creative concept. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments and all changes and modifications that fall within the scope of the present invention.

[0052] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. It should be pointed out that any modifications, equivalent replacements and improvements made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. An exhaust structure, characterized in that: It includes a first channel provided on the reagent disc base, a through hole provided on the reagent disc film, and a second channel on the cover connected to the reagent disc film; The first channel is connected to the reaction hole on the reagent disk base; the first channel, the through hole and the second channel are connected to each other to form an exhaust channel; The first channel is located below the second channel, and the height of the second channel is higher than the height of the annular liquid flow channel provided on the reagent disk.

2. An exhaust structure according to claim 1, characterized in that: A buffer tank communicated with the first channel is provided on the reagent disk base, and the buffer tank is aligned with the through hole.

3. An exhaust structure according to claim 2, characterized in that: The buffer groove is a circular groove, a square groove or a special-shaped groove.

4. An exhaust structure according to claim 2, characterized in that: The cross-sectional area of ​​the buffer groove is larger than the cross-sectional area of ​​the through hole.

5. An exhaust structure according to any one of claims 1 to 4, characterized in that: The covering member is a retaining ring or an upper film provided on the reagent disc film.

6. An exhaust structure according to claim 5, characterized in that: The second channel is a groove arranged on the retaining ring.

7. The exhaust structure according to claim 5, characterized in that: The second channel is the channel formed after the glue layer is removed from the upper film.

8. An exhaust structure according to any one of claims 1 to 4, characterized in that: The second channel width is 0.1-3 mm.

9. An exhaust structure according to claim 8, characterized in that: The second channel width is 0.3 mm.

10. A reagent disc, characterized in that: The reagent disc comprises the exhaust structure according to any one of claims 1 to 9.

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